Digital Commons Network^™

02-08-2024 Hsc Committee Minutes, Helen Maestas

HSC Committee (A subcommittee of the UNM Board of Regents)

02-08-2024 HSC Committee Minutes

February 8, 2024, Caa

Minutes

No abstract provided.

Dimensional Changes In The Skulls Of Ancient Children With Age In Xinjiang, China, Li Haijun, Jing Zhou, Yujie Zhou, Feng Chen, Hailong Zhang, Chang Fu, Bo Wang, Xiaoyong Xiao

Human Biology Open Access Pre-Prints

Many scholars have conducted research on the growth patterns of children’s skulls in terms of skull size, head circumference, cranial cavity volume, and so forth. This study compared and analyzed 20 skull measurement indexes of different ages from 38 children’s skulls (aged 2–15) and 87 adult female skulls (aged 20–40) at the Zaghunluq cemetery in Xinjiang, China, in an attempt to figure out how the size Children’s of ancient children’s skulls changed with age. Analysis of variance (ANOVA) showed that there were significant differences between the six age groups (2 years, 3–5 years, 6–8 years, 9–11 years, 12–15 years, and …

Understanding Faculty Experiences In Implementing Accessible Course Design Strategies, Stacy Rice

Walden Dissertations and Doctoral Studies

Faculty who have experience working with individuals with disabilities are likely to have positive feelings about accessibility however, that does not always lead to faculty adoption of accessible course design practices. A gap existed in academic research about what was known of faculty experiences in the implementation of accessible course design practices at a 4-year university in the Midwest. Exploring faculty experience gave insight to future programming needs. Guided by Mezirow’s transformational learning theory, this qualitative project study explored faculty experiences while implementing accessible course design practices to improve access for students with disabilities. Sixteen faculty participated in 1:1 interviews …

Kodai: Framework Towards Data Augmentation Of Large Language Models In Machine Learning, Rick Rejeleene

Theses and Dissertations

Machine Learning is rapidly advancing at an incredible pace due to an increase in computational size, and availability of data. Data is the cornerstone of machine learning algorithms. Information quality has a profound impact on the performance of machine learning systems. Supervised, Unsupervised, and Reinforcement learning are three major ways of performing machine learning. Self-supervised learning, part of unsupervised learning, has made breakthroughs in engineering and research by using Large Language Models (LLM). LLM are a type of neural network, used for language understanding and generation. Recently, LLM has taken a distinct lead by demonstrating state-of-the-art capabilities in natural language …

Determining The Surface PKA Of Perfluorooctanoic Acid, Lila J. Musegades, Owen P. Curtin, Jenée D. Cyran

Chemistry and Biochemistry Faculty Publications and Presentations

Perfluorooctanoic acid (PFOA) is an environmentally prevalent and persistent organic pollutant with toxic and bioaccumulative properties. Despite the known importance of perfluorinated pollutants in the global environment, molecular-level details of the physicochemical behavior of PFOA on aqueous interfaces remain poorly understood. Here, we utilized two surface-specific techniques, vibrational sum frequency generation spectroscopy (SFG) and surface tensiometry, to investigate the pH-induced structural changes of PFOA and octanoic acid (OA) and determined the apparent pK_a at the air–water surface. The SFG spectra and surface activity model were investigated over a wide range of pHs. With the surface tension measurements, the …

Addressing A Pre-Clinical Pipeline Gap: Development Of The Pediatric Acute Myeloid Leukemia Patient-Derived Xenograft Program At Texas Children's Hospital At Baylor College Of Medicine, Alexandra M Stevens, Maci Terrell, Raushan Rashid, Kevin E Fisher, Andrea N Marcogliese, Amos Gaikwad, Pulivarthi Rao, Chelsea Vrana, Michael Krueger, Michael Loken, Andrew J Menssen, Jacqueline A Cook, Noah Keogh, Michelle Alozie, Hailey Oviedo, Alan K Gonzalez, Tamilini Ilangovan, Julia Kim, Sohani Sandhu, Michele S Redell

Faculty, Staff and Students Publications

The survival rate of pediatric acute myeloid leukemia (pAML) is currently around 60%. While survival has slowly increased over the past few decades, the development of novel agents likely to further improve survival for this heterogeneous patient population has been limited by gaps in the pAML pre-clinical pipeline. One of the major hurdles in evaluating new agents for pAML is the lack of pAML patient-derived xenograft (PDX) models. Unlike solid tumors and other types of leukemias, AML is notoriously hard to establish in mouse models, likely due in part to the need for specific human microenvironment elements. Our laboratory at …

Processes For Identifying Caregivers And Screening For Caregiver And Patient Distress In Community Oncology: Results From Wf-1803cd., Chandylen L. Nightingale, Anna C. Snavely, Laurie E. Mclouth, Emily V. Dressler, Erin E. Kent, Christian S. Adonizio, Suzanne C. Danhauer, Rachel Cannady, Judith O. Hopkins, Heather Kehn, Kathryn E. Weaver, Katherine R. Sterba

Behavioral Science Faculty Publications

BACKGROUND: Despite their vital roles, informal caregivers of adult cancer patients are commonly overlooked in cancer care. This study describes processes for identifying cancer caregivers and processes for distress screening and management among caregivers and patients in the understudied community oncology setting.

METHODS: Supportive care leaders from the National Cancer Institute Community Oncology Research Program practices completed online survey questions regarding caregiver identification, caregiver and patient distress screening, and distress management strategies. We described practice group characteristics and prevalence of study outcomes. Multivariable logistic regression explored associations between practice group characteristics and caregiver identification in the electronic health record (EHR). …

Symbiosis, Dysbiosis And The Impact Of Horizontal Exchange On Bacterial Microbiomes In Higher Fungus-Gardening Ants, Blake Bringhurst, Matthew J. Greenwold, Katrin Kellner, Jon N. Seal

Biology Faculty Publications and Presentations

Advances in our understanding of symbiotic stability have demonstrated that microorganisms are key to understanding the homeostasis of obligate symbioses. Fungus-gardening ants are excellent model systems for exploring how microorganisms may be involved in symbiotic homeostasis as the host and symbionts are macroscopic and can be easily experimentally manipulated. Their coevolutionary history has been well-studied; examinations of which have depicted broad clade-to-clade specificity between the ants and fungus. Few studies hitherto have addressed the roles of microbiomes in stabilizing these associations. Here, we quantified changes in microbiome structure as a result of experimentally induced horizontal exchange of symbionts. This was …

The Grizzly, February 8, 2024, Marie Sykes, Sean Mcginley, Kate Horan, Kathy Logan, Andrew J. Perez, Adam Denn, Dominic Minicozzi

Ursinus College Grizzly Newspaper, 1978 to Present

Restructuring VP Positions • Steam Bending With Adriane Colburn • 2024 Watson Fellowship Finalists • The Writing Fellow Experience • Jasmine's Journey of Sushi • Swimmers Gear Up for Champs • Senior Day Sweep: Ursinus College Men's Wrestling

Hepatitis C Virus Detection And Management After Implementation Of Universal Screening In Pregnancy, Sarah Boudova, Danielle Tholey, Elizabeth Ferries-Rowe

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Accurately identifying cases of hepatitis C virus has important medical and public health consequences. In the setting of rising hepatitis C virus prevalence and highly effective treatment with direct-acting antivirals, the Society for Maternal-Fetal Medicine guidelines recently changed to recommend universal screening for hepatitis C virus during pregnancy. However, there is little data on the influence of this policy change on case identification and management. OBJECTIVE: We aimed to examine the influence of universal hepatitis C virus screening on our patient population. Our primary objective was to determine if there was a difference in the detected hepatitis C virus …

Neurovascular Complications Of Iatrogenic Fusarium Solani Meningitis, Nora Strong, Grant Meeks, Sunil A. Sheth, Louise Mccullough, Julian A. Villalba, Chunfeng Tan, Andrew Barreto, Jose Campo Maldonado, Victoria Parada, Ameer E. Hassan

School of Medicine Publications

A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States. To highlight the severe complications associated with fusarium infection acquired in this manner, we report data, clinical courses, and outcomes from 13 patients in the outbreak who presented with …

Drivers Of Anticoagulant Rodenticide Exposure In Fishers (Pekania Pennanti) Across The Northeastern United States, Georgianna Silveira, Jacqueline L. Frair, Lisa Murphy, Julie C. Ellis, David Needle, Stephanie A. Cunningham, Amanda Watson, Aaron Facka, Patrick Tate, Shevenell Webb, Kim Royar, Chris Bernier, Thomas Keller, Krysten Schuler

Faculty Publications

Studies in parts of Europe, New Zealand, and North America indicate uptake of anticoagulant rodenticides (ARs) by predatory mammals to be widespread and common, with proximity to urban and agricultural areas being an important driver of exposure. Yet, little is known regarding the patterns and drivers of AR exposure in predatory mammals within more forest-dominated landscapes. Across the forest-dominated northeastern United States (US), a region spanning Pennsylvania to Maine, we tested livers from 597 fisher (Pekania pennanti) obtained from the legal harvest for 11 anticoagulant rodenticide compounds. We used kriging to determine potential hot zones (within or among states) and …

A Multi-Year Longitudinal Study Exploring The Impact Of The Covid-19 Pandemic On Students’ Familiarity And Perceptions Of Active Learning, Briana Craig, Jeremy L. Hsu

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The COVID-19 pandemic caused nearly ubiquitous emergency remote teaching in both secondary and post-secondary education. While there has been a plethora of work examining how instructors adjusted classes to incorporate active learning during emergency remote teaching, there has only been minimal work examining how such emergency remote teaching may have influenced students’ perceptions of active learning. Here, we conduct a longitudinal multi-cohort study at one institution across nine semesters before, during, and after emergency remote teaching due to the pandemic to explore how college students’ familiarity and perceptions of active learning have shifted over time because of the pandemic. Our …

Minutes, Faculty Affairs Committee Meeting, Thursday, February 08, 2024, Faculty Affairs Committee

Faculty Affairs Committee Minutes

No abstract provided.

Scaffold Protein Sh3bp2 Signalosome Is Pivotal For Immune Activation In Nephrotic Syndrome., Tarak Srivastava, Robert E. Garola, Jianping Zhou, Varun C. Boinpelly, Mohammad Rezaiekhaligh, Trupti Joshi, Yuexu Jiang, Diba Ebadi, Siddarth Sharma, Christine Sethna, Vincent S. Staggs, Ram Sharma, Debbie S. Gipson, Wei Hao, Yujie Wang, Laura H. Mariani, Jeffrey B. Hodgin, Robert Rottapel, Teruhito Yoshitaka, Yasuyoshi Ueki, Mukut Sharma

Manuscripts, Articles, Book Chapters and Other Papers

Despite clinical use of immunosuppressive agents, the immunopathogenesis of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) remains unclear. Src homology 3-binding protein 2 (SH3BP2), a scaffold protein, forms an immune signaling complex (signalosome) with 17 other proteins, including phospholipase Cγ2 (PLCγ2) and Rho-guanine nucleotide exchange factor VAV2 (VAV2). Bioinformatic analysis of human glomerular transcriptome (Nephrotic Syndrome Study Network cohort) revealed upregulated SH3BP2 in MCD and FSGS. The SH3BP2 signalosome score and downstream MyD88, TRIF, and NFATc1 were significantly upregulated in MCD and FSGS. Immune pathway activation scores for Toll-like receptors, cytokine-cytokine receptor, and NOD-like receptors were increased in …

Immunoglobulin Replacement Products Protect Against Sars-Cov-2 Infection In Vivo Despite Poor Neutralizing Activity, Ofer Zimmerman, Alexa Michelle Altman Doss, Baoling Ying, Chieh-Yu Liang, Samantha R. Mackin, Hannah G. Davis-Adams, Lucas J. Adams, Laura A. Vanblargan, Rita E. Chen, Suzanne M. Scheaffer, Pritesh Desai, Saravanan Raju, Tarisa L. Mantia, Caitlin C. O'Shaughnessy, Jennifer Marie Monroy, H. James Wedner, Christopher J. Rigell, Andrew L. Kau, Tiffany Biason Dy, Zhen Ren, Jackson S. Turner, Jane A. O'Halloran, Rachel M. Presti, Peggy L. Kendall, Daved H. Fremont, Ali H. Ellebedy, Michael S Diamond

2020-Current year OA Pubs

Immunoglobulin (IG) replacement products are used routinely in patients with immune deficiency and other immune dysregulation disorders who have poor responses to vaccination and require passive immunity conferred by commercial antibody products. The binding, neutralizing, and protective activity of intravenously administered IG against SARS-CoV-2 emerging variants remains unknown. Here, we tested 198 different IG products manufactured from December 2019 to August 2022. We show that prepandemic IG had no appreciable cross-reactivity or neutralizing activity against SARS-CoV-2. Anti-spike antibody titers and neutralizing activity against SARS-CoV-2 WA1/2020 D614G increased gradually after the pandemic started and reached levels comparable to vaccinated healthy donors …

Foster Care, Aces, And Social Communication Development: A Mixed Methods Study, Caroline Marie Giuffre

Theses and Dissertations

A childhood spent in foster care has been linked to various adverse childhood experiences (ACEs) including neglect, maltreatment, and physical abuse. The presence of ACEs has the potential to negatively impact neurological development. Our study seeks to inform practicing speech-language pathologists on the potential risks of a history of foster care on the pragmatic domain of language: social communication. The current literature focuses more on general language development, such as expressive language or the prevalence of language delays. This article details our use of a survey study given to adoptive parents of foster children on their child’s social communication abilities. …

The Current - Volume 34 Issue 8, Nova Southeastern University

Student Newspapers

No abstract provided.

Relational Health, Minority Stress, And Psychological Well-Being Among Sexual Orientation And Gender Minority Counseling Students, Jinnelle V. Powell

Walden Dissertations and Doctoral Studies

Sexual orientation and gender minority (SGM) counseling students in the United States are exposed to minority stress, which has been linked to psychological distress, during counselor training. There is an expectation that counseling students are well so that it does not interfere with their helping role. Scholarship in other disciplines shows that a sense of belonging and community can serve as protective factors against minority stress for SGM individuals. The purpose of this quantitative, correlational study was to investigate the influence of minority stress and relational health (in counselor education and broader communities) on SGM counseling students’ psychological well-being, a …

Religion And Gender-Based Preferences In Therapist Selection Among Orthodox Jews, Yehuda L. Rosen

Walden Dissertations and Doctoral Studies

The preferences of Orthodox Jews when choosing a therapist are important to understand, as they can inform practice for individuals, clinics, and referral agencies. The purpose of this study was to determine the preferences for gender-matched therapists, Orthodox Jewish therapists, and specific therapist characteristics among Orthodox Jews. The study was based on Bordin’s working alliance model of psychotherapy, which contends that a strong working alliance is necessary for effective psychotherapy. The research questions were used to explore whether Orthodox Jewish men and women differed in their preferences for gender-matched or Orthodox Jewish therapists, whether religiosity predicted a preference for gender-matched …

Efficacy And Safety Of Artificial Tears Containing Lipidure And Hypromellose For The Treatment Of Moderate Dry Eye Disease In Contact Lens Wearers, Caterina Gagliano, Marco Zeppieri, Antonio Longo, Giovanni Rubegni, Roberta Amato, Roberta Foti, Francesco Cappellani, Massimiliano Cocuzza, Federico Visalli, Ludovica Cannizzaro, Alessandro Avitabile, Giuseppe Gagliano, Lucia Lapenna, Fabiana D'Esposito

Wills Eye Hospital Papers

Background and Objectives: Dry eye disease (DED) affects 5–50% of the global population and deeply influences everyday life activities. This study compared the efficacy, tolerability, and safety of novel Respilac artificial tears containing lipidure and hypromellose (HPMC) with the widely used Nextal artificial tears, which are also HPMC-based, for the treatment of moderate DED in contact lenses (CL) wearers.

Materials and Methods: In a prospective, single-center, randomized investigation, 30 patients aged ≥18 years, diagnosed with moderate DED, and wearing CL were randomly assigned to the Respilac (n = 15) or Nextal group (n = 15). Patients self-administrated one drop of …

Prex1 Improves Homeostatic Proliferation To Maintain A Naive Cd4+ T Cell Compartment In Older Age, Huimin Zhang, Hirohisa Okuyama, Abhinav Jain, Rohit R Jadhav, Bowen Wu, Ines Sturmlechner, Jose Morales, Shozo Ohtsuki, Cornelia M Weyand, Jӧrg J Goronzy

Faculty, Staff and Student Publications

The human adult immune system maintains normal T cell counts and compensates for T cell loss throughout life, mainly through peripheral homeostatic proliferation after the ability of the thymus to generate new T cells has rapidly declined at adolescence. This process is mainly driven by STAT5-activating cytokines, most importantly IL-7, and is very effective in maintaining a large naive CD4+ T cell compartment into older age. Here, we describe that naive CD4+ T cells undergo adaptations to optimize IL-7 responses by upregulating the guanine-nucleotide exchange factor PREX1 in older age. PREX1 promotes nuclear translocation of phosphorylated STAT5, thereby supporting homeostatic …

Impact Of An Integrated Health, Nutrition, And Early Child Stimulation And Responsive Care Intervention Package Delivered To Preterm Or Term Small For Gestational Age Babies During Infancy On Growth And Neurodevelopment: Study Protocol Of An Individually Randomized Controlled Trial In India (Small Babies Trial), Ranadip Chowdhury, Rukman Manapurath, Ingvild Fossgard Sandøy, Ravi Prakash Upadhyay, Neeta Dhabhai, Saijuddin Shaikh, Harish Chellani, Tarun Shankar Choudhary, Abhinav Jain, Jose Martines, Nita Bhandari, Tor A Strand, Sunita Taneja

Faculty, Staff and Student Publications

BACKGROUND: Preterm and term small for gestational age (SGA) babies are at high risk of experiencing malnutrition and impaired neurodevelopment. Standalone interventions have modest and sometimes inconsistent effects on growth and neurodevelopment in these babies. For greater impact, intervention may be needed in multiple domains-health, nutrition, and psychosocial care and support. Therefore, the combined effects of an integrated intervention package for preterm and term SGA on growth and neurodevelopment are worth investigating.

METHODS: An individually randomized controlled trial is being conducted in urban and peri-urban low to middle-socioeconomic neighborhoods in South Delhi, India. Infants are randomized (1:1) into two strata …

Three-Year Follow-Up Analysis Of Axicabtagene Ciloleucel In Relapsed/Refractory Indolent Non-Hodgkin Lymphoma (Zuma-5), Sattva S Neelapu, Julio C Chavez, Alison R Sehgal, Narendranath Epperla, Matthew Ulrickson, Emmanuel Bachy, Pashna N Munshi, Carla Casulo, David G Maloney, Sven De Vos, Ran Reshef, Lori A Leslie, Olalekan O Oluwole, Ibrahim Yakoub-Agha, Rashmi Khanal, Joseph Rosenblatt, Ronald Korn, Weixin Peng, Christine Lui, Jacob Wulff, Rhine Shen, Soumya Poddar, A Scott Jung, Harry Miao, Sara Beygi, Caron A Jacobson

Faculty, Staff and Student Publications

Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory (R/R) follicular lymphoma (FL). Approval was supported by the phase 2, multicenter, single-arm ZUMA-5 study of axi-cel for patients with R/R indolent non-Hodgkin lymphoma (iNHL; N = 104), including FL and marginal zone lymphoma (MZL). In the primary analysis (median follow-up, 17.5 months), the overall response rate (ORR) was 92% (complete response rate, 74%). Here, we report long-term outcomes from ZUMA-5. Eligible patients with R/R iNHL after ≥2 lines of therapy underwent leukapheresis, followed by lymphodepleting chemotherapy and axi-cel infusion (2 × 106 CAR …

The Cowl - V. 88 N. 3 - February 8, 2024

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 3 - February 8, 2024. 24 pages.

The Mrna-Lnp Vaccines - The Good, The Bad And The Ugly?, Botond Z. Igyártó, Zhen Qin

Department of Microbiology and Immunology Faculty Papers

The mRNA-LNP vaccine has received much attention during the COVID-19 pandemic since it served as the basis of the most widely used SARS-CoV-2 vaccines in Western countries. Based on early clinical trial data, these vaccines were deemed safe and effective for all demographics. However, the latest data raise serious concerns about the safety and effectiveness of these vaccines. Here, we review some of the safety and efficacy concerns identified to date. We also discuss the potential mechanism of observed adverse events related to the use of these vaccines and whether they can be mitigated by alterations of this vaccine mechanism …

Command Injection Attacks In Smart Grids: A Survey, Muhammad Usama, Muhammad Naveed Aman

School of Computing: Faculty Publications

Cybersecurity is important in the realization of various smart grid technologies. Several studies have been conducted to discuss different types of cyberattacks and provide their countermeasures. The false command injection attack (FCIA) is considered one of the most critical attacks that have been studied. Various techniques have been proposed in the literature to detect FCIAs on different components of smart grids. The predominant focus of current surveys lies on FCIAs and detection techniques for such attacks. This article presents a survey of existing works on FCIAs and classifies FCIAs in smart grids according to the targeted component. The impacts of …

Aiming High, Gwendolyn Goguelet

UNH Today Archive

No abstract provided.

Arterial Stiffness And Obesity As Predictors Of Diabetes: Longitudinal Cohort Study, Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang

Research outputs 2022 to 2026

BACKGROUND: Previous studies have confirmed the separate effect of arterial stiffness and obesity on type 2 diabetes; however, the joint effect of arterial stiffness and obesity on diabetes onset remains unclear. OBJECTIVE: This study aimed to propose the concept of arterial stiffness obesity phenotype and explore the risk stratification capacity for diabetes. METHODS: This longitudinal cohort study used baseline data of 12,298 participants from Beijing Xiaotangshan Examination Center between 2008 and 2013 and then annually followed them until incident diabetes or 2019. BMI (waist circumference) and brachial-ankle pulse wave velocity were measured to define arterial stiffness abdominal obesity phenotype. The …