Digital Commons Network^™

Long-Term Outcomes Of Patients With Large B-Cell Lymphoma Treated With Axicabtagene Ciloleucel And Prophylactic Corticosteroids, Olalekan O Oluwole, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

ZUMA-1 safety management cohort 6 investigated the impact of prophylactic corticosteroids and earlier corticosteroids and/or tocilizumab on the incidence and severity of cytokine release syndrome (CRS) and neurologic events (NEs) following axicabtagene ciloleucel (axi-cel) in patients with relapsed/refractory large B-cell lymphoma (R/R LBCL). Prior analyses of cohort 6 with limited follow-up demonstrated no Grade ≥3 CRS, a low rate of NEs, and high response rates, without negatively impacting axi-cel pharmacokinetics. Herein, long-term outcomes of cohort 6 (N = 40) are reported (median follow-up, 26.9 months). Since the 1-year analysis (Oluwole, et al. Blood. 2022;138[suppl 1]:2832), no new CRS was reported. …

Biomarker-Directed Targeted Therapy Plus Durvalumab In Advanced Non-Small-Cell Lung Cancer: A Phase 2 Umbrella Trial, Benjamin Besse, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

For patients with non-small-cell lung cancer (NSCLC) tumors without currently targetable molecular alterations, standard-of-care treatment is immunotherapy with anti-PD-(L)1 checkpoint inhibitors, alone or with platinum-doublet therapy. However, not all patients derive durable benefit and resistance to immune checkpoint blockade is common. Understanding mechanisms of resistance-which can include defects in DNA damage response and repair pathways, alterations or functional mutations in STK11/LKB1, alterations in antigen-presentation pathways, and immunosuppressive cellular subsets within the tumor microenvironment-and developing effective therapies to overcome them, remains an unmet need. Here the phase 2 umbrella HUDSON study evaluated rational combination regimens for advanced NSCLC following failure of …

Estrogen-Induced Glial Il-1Β Mediates Extrinsic Retinal Ganglion Cell Vulnerability In Murine Nf1 Optic Glioma, Yunshuo Tang, Jit Chatterjee, Ngan Wagoner, Stephanie Bozeman, David H Gutmann

2020-Current year OA Pubs

Optic pathway gliomas (OPGs) arising in children with neurofibromatosis type 1 (NF1) can cause retinal ganglion cell (RGC) dysfunction and vision loss, which occurs more frequently in girls. While our previous studies demonstrated that estrogen was partly responsible for this sexually dimorphic visual impairment, herein we elucidate the underlying mechanism. In contrast to their male counterparts, female Nf1

Estimating The Treatment And Prophylactic Economic Value Of New Antimicrobials In Managing Antibiotic Resistance And Serious Infections For Common Pathogens In The Usa: A Population Modelling Study, Jason Gordon, Maria Gheorghe, Cale Harrison, Ryan Miller, James Dennis, Lotte Steuten, Simon Goldenberg, Sumanth Gandra, Amer Al-Taie

2020-Current year OA Pubs

BACKGROUND: Antimicrobial resistance is a growing public health concern. There is a global need to estimate the population-level value of developing new antimicrobials and to ensure the effective use of existing antimicrobials as strategies to counteract antimicrobial resistance. To this aim, population-level value criteria need to be considered alongside conventional value measures.

OBJECTIVE: The objective of this study was to develop a novel modelling approach to estimate the value of new antimicrobials, considering the transmission, diversity and enablement elements of STEDI value.

METHODS: We developed a population-based mathematical model for the assessment of antimicrobial value considering both prophylactic use of …

Causal Relationships Between Pain, Medical Treatments, And Knee Osteoarthritis: A Graphical Causal Model To Guide Analyses, Haadiya Cheema, Robert Brophy, Jamie Collins, Charles L Cox, Ali Guermazi, Mahima Kumara, Bruce A Levy, Lindsey Macfarlane, Lisa A Mandl, Robert Marx, Faith Selzer, Kurt Spindler, Jeffrey N Katz, Eleanor J Murray

2020-Current year OA Pubs

OBJECTIVE: Randomized controlled trials (RCTs) are a gold standard for estimating the benefits of clinical interventions, but their decision-making utility can be limited by relatively short follow-up time. Longer-term follow-up of RCT participants is essential to support treatment decisions. However, as time from randomization accrues, loss to follow-up and competing events can introduce biases and require covariate adjustment even for intention-to-treat effects. We describe a process for synthesizing expert knowledge and apply this to long-term follow-up of an RCT of treatments for meniscal tears in patients with knee osteoarthritis (OA).

METHODS: We identified 2 post-randomization events likely to impact accurate …

Associations Between Covid-19 And Putative Markers Of Neuroinflammation: A Diffusion Basis Spectrum Imaging Study, Wei Zhang, Aaron J Gorelik, Qing Wang, Sara A Norton, Tamara Hershey, Arpana Agrawal, Janine D Bijsterbosch, Ryan Bogdan

2020-Current year OA Pubs

COVID-19 remains a significant international public health concern. Yet, the mechanisms through which symptomatology emerges remain poorly understood. While SARS-CoV-2 infection may induce prolonged inflammation within the central nervous system, the evidence primarily stems from limited small-scale case investigations. To address this gap, our study capitalized on longitudinal UK Biobank neuroimaging data acquired prior to and following COVID-19 testing (N = 416 including n = 224 COVID-19 cases; M

Once-Daily Oral Berotralstat For Long-Term Prophylaxis Of Hereditary Angioedema: The Open-Label Extension Of The Apex-2 Randomized Trial, Sorena Kiani-Alikhan, H James Wedner, Et Al.

2020-Current year OA Pubs

BACKGROUND: Berotralstat is a first-line, once-daily oral plasma kallikrein inhibitor approved for prophylaxis of hereditary angioedema (HAE) attacks in patients 12 years or older.

OBJECTIVE: This analysis examined the safety and effectiveness of long-term prophylaxis with berotralstat.

METHODS: APeX-2 was a phase 3, parallel-group, multicenter trial in patients with HAE caused by C1-inhibitor deficiency (NCT03485911). Part 1 was a randomized, double-blind, placebo-controlled evaluation of 150 and 110 mg of berotralstat over 24 weeks. In part 2, berotralstat-treated patients continued the same treatment, and placebo-treated patients were re-randomized to 150 or 110 mg of berotralstat for 24 weeks. In part 3, …

Cell-Specific Systemic Immune Signatures Associated With Treatment Burden In Neovascular Age-Related Macular Degeneration, Joseph B Lin, Andrea Santeford, Darksha Usmani, Aaditya V Shah, Philip A Ruzycki, Rajendra S Apte

2020-Current year OA Pubs

PURPOSE: Choroidal neovascularization (CNV) accounts for the majority of severe vision loss in neovascular age-related macular degeneration (AMD). Despite therapies that target VEGF, patients are often under-responsive, require frequent eye injections to control disease, and eventually lose some vision despite chronic therapy implicating a multifactorial etiology in treatment response. Genetic studies implicate systemic immunity in AMD and systemic immune cells accumulate within CNV lesions, yet a role for these cells in anti-VEGF response remains undetermined. The purpose of this study was to identify transcriptional signatures of circulating immune cells that are associated with high anti-VEGF treatment burden.

DESIGN: Experimental pilot …

Does Vibrotactile Stimulation Of The Auricular Vagus Nerve Enhance Working Memory? A Behavioral And Physiological Investigation, Gansheng Tan, Josh Adams, Kara Donovan, Phillip Demarest, Jon T Willie, Peter Brunner, Jenna L Gorlewicz, Eric C Leuthardt

2020-Current year OA Pubs

BACKGROUND: Working memory is essential to a wide range of cognitive functions and activities. Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising method to improve working memory performance. However, the feasibility and scalability of electrical stimulation are constrained by several limitations, such as auricular discomfort and inconsistent electrical contact.

OBJECTIVE: We aimed to develop a novel and practical method, vibrotactile taVNS, to improve working memory. Further, we investigated its effects on arousal, measured by skin conductance and pupil diameter.

METHOD: This study included 20 healthy participants. Behavioral response, skin conductance, and eye tracking data were concurrently recorded while the …

Endocrine-Sensitive Disease Rate In Postmenopausal Patients With Estrogen Receptor-Rich/Erbb2-Negative Breast Cancer Receiving Neoadjuvant Anastrozole, Fulvestrant, Or Their Combination: A Phase 3 Randomized Clinical Trial, Cynthia X Ma, Kiran Vij, Jeremy Hoog, Mark A Watson, Erika Crouch, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Adding fulvestrant to anastrozole (A+F) improved survival in postmenopausal women with advanced estrogen receptor (ER)-positive/ERBB2 (formerly HER2)-negative breast cancer. However, the combination has not been tested in early-stage disease.

OBJECTIVE: To determine whether neoadjuvant fulvestrant or A+F increases the rate of pathologic complete response or ypT1-2N0/N1mic/Ki67 2.7% or less residual disease (referred to as endocrine-sensitive disease) over anastrozole alone.

DESIGN, SETTING, AND PARTICIPANTS: A phase 3 randomized clinical trial assessing differences in clinical and correlative outcomes between each of the fulvestrant-containing arms and the anastrozole arm. Postmenopausal women with clinical stage II to III, ER-rich (Allred score 6-8 or …

Antioxidant Properties Of Kombucha Beverage Infused With Ganoderma Lucidum And Green Tea From Camellia Sinensis (L.) Kuntze With Several Fermentation Times, Rizki Rabeca Elfirta, Pamungkas Rizki Ferdian, Iwan Saskiawan, Tri Hadi Handayani, Kayla Faza Gustafri Mandalika, Rini Riffiani, Kasirah Kasirah, Ukhradiya Magharaniq Safira Purwanto

Karbala International Journal of Modern Science

Kombucha is a functional beverage produced through the fermentation of infused tea or Camelia sinensis (L.) Kuntze (CS) by a symbiotic culture of bacteria and yeast. Apparently, the substrate of kombucha can be substituted to enhance its functional properties. Ganoderma lucidum (GL) is a potential substrate reported to have health benefits. This study aims to evaluate antioxidant properties by comparing different formulations and fermentation times. The formulations prepared in the present study varied in the compositions of GL and CS substrates, namely F1 (100% GL), F2 (75% GL: 25% CS), F3 (50% GL: 50% CS), F4 (25% GL: 75% CS), …

Overview Of The Zoonotic Potential And Coinfection Of Sars-Cov-2 In Indonesia, Muhammad Khaliim Jati Kusala, Ni Luh Putu Indi Dharmayanti

Karbala International Journal of Modern Science

In the ASEAN region, Indonesia has the highest overall COVID-19 infection score. The SARS-CoV-2 pandemic first emerged in China and then transmitted sporadically throughout the world. Animals and humans can be infected with the corona virus, so this disease is classified as a zoonotic disease. This review aims to gather information regarding the potential of SARS-CoV-2 as a zoonotic disease and coinfections with several other pathogens in Indonesia. This study collected data demonstrating the potential for COVID-19 to be transmitted from humans to animals, as an evidenced by positive test results for the Bat Coronavirus Antigen in bats. Cats have …

Assessment Of Professional Counseling Dispositions: A Content Validity Analysis, Patrick R. Mullen, Jacob Joseph, Kaitlin Jones Hinchey, Morgan Walker, Jennifer Niles

Teaching and Supervision in Counseling

Counselor educators evaluate the professional counseling dispositions of trainees throughout their development within training programs. There have been few consistent articulations of professional dispositions as many programs and measures define them differently. In our study, we developed the Assessment of Professional Counseling Dispositions (APCD) and performed a content validity study of the measure. Our findings provide evidence for the content validity of the APCD. We discuss these findings, their implications, and future research using the measure.

Counselor Trainee Cognitive Complexity: Peer Interactions And Assessments, Alexandra Gantt-Howrey, Erin Woods, Gulsah Kemer

Teaching and Supervision in Counseling

In their training efforts, counselor educators focus on a variety of characteristics, including cognitive complexity (CC). Cognitively complex counselors can identify and integrate the multiple characteristics and perspectives of their clients and have been found to be generally more empathic and accepting of ambiguity (Castillo 2018; Granello, 2010; Welfare & Borders, 2010b). Although CC is considered as an integral counselor attribute (Castillo, 2018), how CC may be related to within-program peer interactions has yet to be explored. Through this convergent mixed methods study (Creswell & Creswell, 2017), we sought to understand how n = 7 participants’ experiences with and assessments …

Promoting Counselor Trainees’ Clinical Skill Development Using Virtual Reality Simulations, Amber L. Pope, Chelsea Hilliard

Teaching and Supervision in Counseling

Although research on virtual reality (VR) as a pedagogical tool within counselor education is scarce, the parallel use of VR in health sciences education indicates VR simulations may have similar utility and effectiveness in training counselors. This conceptual piece aims to assist counselor educators in building VR simulations for counselors-in-training (CITs). The authors review the research on VR usage in counselor education and explore the practical implications of VR simulations for training counselors. The authors describe the development and utilization of VR simulations across multiple stages of training in a counselor education master’s program to support CITs’ clinical skill development …

The Class Of 2019: Academic Employment Prospects For Counselor Education Doctoral Graduates, Christopher Lawrence, Gregory Hatchett

Teaching and Supervision in Counseling

The purpose of this investigation was to estimate the percentage of counselor education doctoral (CED) program graduates who attained faculty positions within two years of graduation and to compare the number of these graduates to the number of advertised faculty positions during this same timeframe. To do so, we used archival, publicly available data for graduates of CACREP-accredited CED programs during the 2018-2019 academic cycle (N = 314). Approximately two-fifths of these graduates had faculty positions. Graduation from a public university increased the odds of having any faculty post, whereas graduation from a public university and the Carnegie Classification of …

A Model Of Retention And Remediation For Online Counselor Education, Colleen M. Grunhaus, Matthew Lyons

Teaching and Supervision in Counseling

Online counseling programs experience unique retention and gatekeeping challenges. Increased isolation and personal adversities are common factors associated with attrition for online students; and broad-access admission policies of online counseling programs often lead to increased gatekeeping concerns postadmission. Counseling programs develop policies and procedures related to retention, remediation, and dismissal, but extant models of remediation do not also address student retention or the unique challenges of online counselor education. We present a model, The Retention and Remediation Model for Online Counselor Education, that demonstrates a comprehensive policy for retention, remediation, and dismissal in online counseling programs through a three-prong approach …

Perceptions Of The Instructional Research Training Environment And Research Self-Efficacy, Missy Moore, John Mccall, Todd Bolin, Austen Bingham

Teaching and Supervision in Counseling

We examined counselor education and supervision (CES) doctoral students’ (n = 117) perceptions of their instructional RTE and research self-efficacy. Students had more positive perceptions of their instructional RTE and higher research self-efficacy when research courses were taught by counseling faculty. Additionally, the instructional RTE was predictive of research self-efficacy above and beyond intrapersonal, interpersonal, and experiential variables. Implications for counselor education programs are provided.

Professional Identity Development Of Black Doctoral Students In Counselor Education: A Reflexive Model, Olivia T. Ngadjui Phd, Elizabeth A. Doughty Horn

Teaching and Supervision in Counseling

This grounded theory study comprised the perspectives of how past and current Black doctoral students formalized their professional identity in counselor education. Findings included reflexivity as a central theme within the internal process of Black doctoral students navigating counselor education programs and a model of professional identity development.

Relationships Of Empathy And Color-Blind Attitudes On Counseling Students’ Critical Consciousness, Bagmi Das, Maggie M. Parker, Sarah Litt

Teaching and Supervision in Counseling

A critical piece of counselor education is enhancing counselors’ in training (CITs) multicultural competence. Concepts included in CIT cultural development include both developing empathy (Constantine, 2001) and dismantling color-blind racial attitudes` (Neville et al., 2013). Thus, this study presents multiple regression to explore the relationships between color blindness, empathy development, and critical consciousness of 166 counseling students. Results indicate that that empathy and color-blind attitudes have associations with some aspects of critical consciousness, but not sociopolitical participation. Implications for counselor education and directions for future research are discussed.

Social Justice Identity And Program Evaluation: A Pilot Study Of Cmhc Students, Heidi L. Henry

Teaching and Supervision in Counseling

Program development and evaluation can be used to address historical inequities in mental health, but they are scarcely studied in counselor education. The purpose of this pilot study was to examine how taking one social-justice focused CMHC management course impacted 66 counseling students’ social justice identity and program evaluation understanding. Participating students completed a group program proposal focused on social justice and program evaluation. To assess change in their social justice attitudes, behaviors, and program evaluation understanding, they completed a demographic questionnaire, pre-test, and post-test. The results, derived from t-tests and Wilcoxon Signed-Rank tests, indicated a significant improvement from pre- …

Danes In Argentina: The Emigration Story Of The Ambrosius Family, Inge Ambrosius

The Bridge

I have had a box of newspaper clippings, letters, pictures, books, and other materials about Danish immigrants in Argentina for many years. Many of my relatives live in Argentina, and the material was assembled by my grandmother and my father. When I retired from teaching high school history and geography, I finally had the time to look at the material. Among other things, the box contained the memoirs of my great-grandfather’s younger brother, Niels Jensen Ambrosius, “Memories of my life and whereabouts in Argentina.” They were written in 1951 when Niels was eighty-four years old. Reading them made me curious, …

Panel Session. Game Changers: Connections And Empowerment Through Coaching, Anne Carr, Bre Henry, Rachel Martin, Connie Price Smith

WHEMN Conference

This panel spotlights the achievements and contributions of collegiate women coaches and sports administrators and will delve into the unique challenges and triumphs experienced by women in leadership roles within the realm of collegiate sports. Panelists will share personal journeys, insights and strategies for success and will offer invaluable perspectives on leadership, mentorship and breaking through barriers.

• Anne Carr, executive director, Student-Athlete Development, Mississippi State University
• Bre Henry, head coach, Volleyball, The University of Mississippi
• Rachel Martin, head coach, Rifle, The University of Mississippi
• Connie Price Smith, head coach, Men's and Women's Track & Field, The …

Wheat Landraces, Small Farmers And Urban Consumers: Revival Of Einkorn In Turkey, Nurcan Atalan Helicke

Journal of Critical Global Issues

Cultivated for more than 10,000 years, wheat (Triticum) is one of the world’s most widely grown and important crops. Wheat has sustained humans for thousands of years in a multitude of ways. In recent years, there has been a global movement to revive wheat landraces. Landraces are typically adapted to a local area and to traditional farming systems. This article examines the revival of wheat landrace, einkorn (Triticum monoccoccum L. subsp. monoccoccum) through a case study of Turkey. There is limited literature examining the interaction of actors in decision-making processes that balance subsistence and market motivations. …

Environmental Analysis Of Codfish Production And Consumption In Portugal, Ayla Frost, Joana Almeida, Joana Dionisio, Radu Godina, Cátia Magro

Journal of Critical Global Issues

Codfish, a typical dish consumed frequently in Portugal, is fished in the cold Northern Atlantic waters far from the Portuguese coast. Thus, regional tensions and the environmental impacts of Portuguese codfish importation and production are significant current issues. The present study uses a life cycle assessment methodology to evaluate the array of environmental impacts of the production of 1 kg of codfish, following a cradle to gate approach. The life cycle inventory was grouped into catch and preprocessing, transit, and curing stages. The data collection of products and processes in each stage was based on scientific peer reviewed documents, technical …

Socio-Economic Integration Strategies Of “Former Rwandan Refugees” In Yaoundé, Cameroon., Michèle Mc Signé

Journal of Critical Global Issues

This research is entitled The Socio-economic Integration Strategies of “former Rwandan refugees” in Yaoundé, Cameroon. This is an analysis of immigrants who were once under international protection. The presence of former Rwandan refugees in the city of Yaoundé dates back to the time of the 1994 Rwandan genocide. With the advent of the cessation clause in 2018, we are faced with individuals who must find ways of coping with the new realities. Based on the assimilation and integration of immigrant, this study analyzes the integration strategies of former Rwandan refugees. This integration is facilitated by a social context described as …

Guided Missiles: Nanoparticles Enhancing Cisplatin's Cancer-Fighting Accuracy, Leroy Rueben Alvares

International Conference on ‘NANOSCIENCE AND NANOTECHNOLOGY'

No abstract provided.

Diagnosis And Treatment Of Ovarian Cancer Using Magnetic Nanoparticles, E John, T Anil

International Conference on ‘NANOSCIENCE AND NANOTECHNOLOGY'

No abstract provided.

Nanotechnology In Dental Caries Prevention And Treatment., Neetha Shenoy

International Conference on ‘NANOSCIENCE AND NANOTECHNOLOGY'

No abstract provided.

Application Of Nanomaterials In Ovarian Tissue Engineering, Maya Lakshmanan, Manasa Nune

International Conference on ‘NANOSCIENCE AND NANOTECHNOLOGY'

No abstract provided.