Digital Commons Network^™

Hormonal Testing In Menstrual Blood Enhances Reproductive Freedom, Laura Detti, William E Gibbons

Faculty, Staff and Students Publications

No abstract provided.

Reply: Efficacy Of Segmented Axial Length And Artificial Intelligence Approaches To Intraocular Lens Power Calculation In Short Eyes, Karim Kozhaya, Peter I Kenny, Li Wang, Mitchell P Weikert, Douglas D Koch

Faculty, Staff and Students Publications

No abstract provided.

Rosiglitazone Improves Insulin Resistance But Does Not Improve Exercise Capacity In Individuals With Impaired Glucose Tolerance: A Randomized Clinical Study, Layla A Abushamat, Irene E Schauer, Cecilia C Low Wang, Stacey Mitchell, Leah Herlache, Mark Bridenstine, Roy Durbin, Janet K Snell-Bergeon, Judith G Regensteiner, Jane Eb Reusch

Faculty, Staff and Students Publications

Dysmetabolic states, such as type 2 diabetes (T2D), characterized by insulin resistance (IR), are associated with fatty liver, increased cardiovascular disease (CVD) risk, and decreased functional exercise capacity (FEC). Rosiglitazone (RO) improves exercise capacity and IR in T2D. However, the effects of RO on FEC and other markers of CVD risk in prediabetes are unknown. We hypothesized that insulin sensitization with RO would improve exercise capacity and markers of CVD risk in participants with impaired glucose tolerance (IGT). Exercise performance (peak oxygen consumption and oxygen uptake kinetics), IR (homeostasis model assessment of IR and quantitative insulin sensitivity check index), and …

The Hidden Expense Of Stethoscope Hygiene Versus The Real Costs Of Failure, William Frank Peacock

Faculty, Staff and Students Publications

No abstract provided.

Nadph Oxidase Overexpression And Mitochondrial Oxphos Impairment Are More Profound In Human Hearts Donated After Circulatory Death Than Brain Death, Nandan K Mondal, Shiyi Li, Abdussalam E Elsenousi, Aladdein Mattar, Katherine V Nordick, Harveen K Lamba, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao

Faculty, Staff and Students Publications

This study investigated cardiac stress and mitochondrial oxidative phosphorylation (OxPhos) in human donation after circulatory death (DCD) hearts regarding warm ischemic time (WIT) and subsequent cold storage and compared them with that of human brain death donor (DBD) hearts. A total of 24 human hearts were procured for the research study-6 in the DBD group and 18 in the DCD group. DCD group was divided into three groups (n = 6) based on different WITs (20, 40, and 60 min). All hearts received del Nido cardioplegia before being placed in normal saline cold storage for 6 h. Left ventricular …

Highlights Of How Single-Cell Analyses Are Illuminating Differentiation And Disease In The Gastric Corpus, Mahliyah Adkins-Threats, Yang-Zhe Huang, Jason C Mills

Faculty, Staff and Students Publications

Single-cell RNA-sequencing (scRNA-seq) has emerged as a powerful technique to identify novel cell markers, developmental trajectories, and transcriptional changes during cell differentiation and disease onset and progression. In this review, we highlight recent scRNA-seq studies of the gastric corpus in both human and murine systems that have provided insight into gastric organogenesis, identified novel markers for the various gastric lineages during development and in adults, and revealed transcriptional changes during regeneration and tumorigenesis. Overall, by elucidating transcriptional states and fluctuations at the cellular level in healthy and disease contexts, scRNA-seq may lead to better, more personalized clinical treatments for disease …

Postsynaptic Β1 Spectrin Maintains Na+ Channels At The Neuromuscular Junction, Ozlem Sert, Xiaoyun Ding, Chuansheng Zhang, Ruifa Mi, Ahmet Hoke, Matthew N Rasband

Faculty, Staff and Students Publications

Spectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4 spectrin) were reported to cause both neuropathy and myopathy. Although β4 spectrin's role in neurons is mostly understood, its function in skeletal muscle, another excitable tissue subject to large forces, is unknown. Here, using a muscle specific β4 spectrin conditional knockout mouse, we show that β4 spectrin does not contribute to muscle function. In addition, we show β4 spectrin is not present …

The Pug Flap: Conjoined Profunda Artery Perforator And Upper Gracilis Flap For Breast Reconstruction, Isra Abdulwadood, Lacey R Pflibsen, Nicholas R Jarvis, Sebastian Winocour, Alanna M Rebecca, William J Casey, Edward M Reece

Faculty, Staff and Students Publications

Abdominal-based free flaps are the mainstay of autologous breast reconstruction; however, the region may not be ideal for patients with inadequate soft tissue or history of abdominal surgery. This case describes the use of a novel conjoined flap based on the profunda artery perforator and upper gracilis pedicles, named the perforator and upper gracilis (PUG) flap. This flap design aims to maximize medial thigh flap volume while ensuring robust tissue perforation. Here, we present our experience with the PUG flap in a breast cancer patient undergoing autologous reconstruction. The patient was a 41-year-old woman seeking nipple-sparing mastectomy and immediate autologous …

Echocardiographic Image Collection And Evaluation In Infants With Chd: Lessons Learned From The Imaging Core Lab For The Residual Lesion Score Study, Jami C Levine, Steven Colan, Felicia Trachtenberg, Edward Marcus, Matthew Ferguson, Anitha Parthiban, Carolyn Taylor, Andreea Dragulescu, Benjamin Goot, Ronald V Lacro, Carol Mcfarland, Shanthi Narasimhan, Matthew O'Connor, Marcus Schamberger, Shubhika Srivistava, Michael Taylor, Meena Nathan

Faculty, Staff and Students Publications

Many factors affect patient outcome after congenital heart surgery, including the complexity of the heart disease, pre-operative status, patient specific factors (prematurity, nutritional status and/or presence of comorbid conditions or genetic syndromes), and post-operative residual lesions. The Residual Lesion Score is a novel tool for assessing whether specific residual cardiac lesions after surgery have a measurable impact on outcome. The goal is to understand which residual lesions can be tolerated and which should be addressed prior to leaving the operating room. The Residual Lesion Score study is a large multicentre prospective study designed to evaluate the association of Residual Lesion …

The Role Of Artificial Intelligence For Providing Scientific Content For Laboratory Medicine, Alan H B Wu, Allan S Jaffe, William Franklin Peacock, Pete Kavsak, Dina Greene, Robert H Christenson

Faculty, Staff and Students Publications

Background: Artificial intelligence (AI) promises to become an important tool in the practice of laboratory medicine. AI programs are available online that can provide concise medical and laboratory information within seconds after a question is submitted.

Methods: We posed the following contemporary and relevant question for clinical chemists using an AI program: "Should labs eliminate CK-MB testing?" The results of this inquiry were critically reviewed by a cardiologist, emergency department physician, and clinical laboratorians for accuracy and appropriateness.

Results: An AI report answering this question was generated within 15 s. The experts felt that the information was inaccurate with the …

Thiazide Diuretics Vs. Other Antihypertensive Drug Classes, Arindam Sarkar, Katelyn D Sarkar

Faculty, Staff and Students Publications

No abstract provided.

Invited Commentary On Andersen S, Et Al Developmental Windows Of Environmental Vulnerability For Inflammatory Bowel Disease, David A Simon, Richard Kellermayer

Faculty, Staff and Students Publications

No abstract provided.

Fine-Needle Aspiration Of Amyloidoma: A Critical Analysis, Nisha S Ramani, Bhuvaneswari Krishnan

Faculty, Staff and Students Publications

Background: Amyloid, presenting as a mass, is termed amyloidoma. Among the reported cases, fine-needle aspiration (FNA) of amyloid is often misinterpreted as acellular nondiagnostic material.

Methods: A computer search of all FNAs was performed and cases diagnosed as amyloidoma were identified.

Results: Among 11,956 cases and 20,634 FNAs, there were six cases and 12 FNAs of amyloidoma. One case with mucin/myxoid matrix was misinterpreted as amyloid, which on our review was Congo red negative. All five other cases of amyloidoma were adequate for evaluation. The smears showed most of the aspirated contents in the middle of the slide and it …

Fatty Acids And Their Proteins In Adipose Tissue Inflammation, Rahul Mallick, Sanjay Basak, Ranjit Kumar Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

Health & Biomedical Sciences Faculty Publications

Chronic low-grade adipose tissue inflammation is associated with metabolic disorders. Inflammation results from the intertwined cross-talks of pro-inflammatory and anti-inflammatory pathways in the immune response of adipose tissue. In addition, adipose FABP4 levels and lipid droplet proteins are involved in systemic and tissue inflammation. Dysregulated adipocytes help infiltrate immune cells derived from bone marrow responsible for producing cytokines and chemokines. When adipose tissue expands in excess, adipocyte exhibits increased secretion of adipokines and is implicated in metabolic disturbances due to the release of free fatty acids. This review presents an emerging concept in adipose tissue fat metabolism, fatty acid handling …

Correction: Psychosocial Moderators Of Polygenic Risk Scores Of Inflammatory Biomarkers In Relation To Grimage, Amanda J F Tamman, Dora Koller, Sheila Nagamatsu, Brenda Cabrera-Mendoza, Chadi Abdallah, John H Krystal, Joel Gelernter, Janitza L Montalvo-Ortiz, Renato Polimanti, Robert H Pietrzak

Faculty, Staff and Students Publications

No abstract provided.

Psychosocial Moderators Of Polygenic Risk Scores Of Inflammatory Biomarkers In Relation To Grimage, Amanda J F Tamman, Dora Koller, Sheila Nagamatsu, Brenda Cabrera-Mendoza, Chadi Abdallah, John H Krystal, Joel Gelernter, Janitza L Montalvo-Ortiz, Renato Polimanti, Robert H Pietrzak

Faculty, Staff and Students Publications

GrimAge acceleration has previously predicted age-related morbidities and mortality. In the current study, we sought to examine how GrimAge is associated with genetic predisposition for systemic inflammation and whether psychosocial factors moderate this association. Military veterans from the National Health and Resilience in Veterans study, which surveyed a nationally representative sample of European American male veterans, provided saliva samples for genotyping (N = 1135). We derived polygenic risk scores (PRS) from the UK Biobank as markers of genetic predisposition to inflammation. Results revealed that PRS for three inflammatory PRS markers—HDL (lower), apolipoprotein B (lower), and gamma-glutamyl transferase (higher)—were associated …

4-H Volunteer Orientation Handbook, Joeseph D. Drake

UNH Cooperative Extension

New Hampshire 4-H Volunteer Orientation handbook.

Best Practices For Helicobacter Pylori Management, David Y Graham

Faculty, Staff and Students Publications

For decades, antimicrobial therapy for Helicobacter pylori infection has been given empirically, and the results of therapy (success or failure) have either not been confirmed or when confirmed have not been used to modify prescribing behavior. These practices coupled with increasing antibiotic resistance have resulted in low cure rates overall. Susceptibility testing for H pylori has increasingly become available, especially in the United States. Availability of susceptibility-based therapy has encouraged adoption of the principles of antimicrobial stewardship for H pylori infection (eg, limiting antibiotic choice to antibiotics for which the infection is susceptible given at optimal doses, formulations, frequency of …

Collaborative System Usability In Spaceflight Analog Environments Through Remote Observations, Shivang Shelat, Jessica J. Marquez, Jimin Zheng, John A. Karasinski

Faculty Research, Scholarly, and Creative Activity

The conventional design cycle in human–computer interaction faces significant challenges when applied to users in isolated settings, such as astronauts in extreme environments. Challenges include obtaining user feedback and effectively tracking human–software/human–human dynamics during system interactions. This study addresses these issues by exploring the potential of remote conversation analysis to validate the usability of collaborative technology, supplemented with a traditional post hoc survey approach. Specifically, we evaluate an integrated timeline software tool used in NASA’s Human Exploration Research Analog. Our findings indicate that voice recordings, which focus on the topical content of intra-crew speech, can serve as non-intrusive metrics for …

Measuring The Presentation Of Supporting Content For A Set Of Learning Objectives Throughout The States Of An Educational Game Tree, Michael L. Hastriter Jr.

Theses and Dissertations

In an era of evolving warfare, the Department of Defense (DoD) recognizes the value of serious games as immersive tools for teaching critical concepts. This thesis introduces a pioneering framework tailored to enhance learning objectives through the presentation of educational game content. This addresses the unique needs of the DoD and other educators who use games by providing measurements to assess educational games. This researches investigates how instructors might assess games as potential teaching tools. It establishes a five-phase process, providing a framework to assess educational games against predefined learning objectives and informing future game development. This thesis demonstrates games …

Enhancing Port Efficiency And Lead Time Reduction Through Predictive Analysis: A Case Study Of Container Management At Khalifa Bin Salman Port, Abdulaziz A. Aljalahma

Theses and Dissertations

Khalifa bin Salman Port (KBSP), a key pillar in Bahrain's maritime infrastructure, is the focal point of this study, highlighting the significant role of predictive analytics in optimizing port operations. This thesis analyzes container throughput data from 2017 to 2022, provided by Bahrain's Ministry of Transportation database. This data forms the basis for forecasting the 2023 throughput. The study thoroughly compares these predictions with the actual 2023 data, assessing the predictive model's accuracy. The findings underscore the importance of predictive analytics in strategic decision-making for port management, focusing on enhancing operational efficiency and reducing lead times. This research offers a …

Modeling & Engineering Of Usmepcom Business Intelligence Data, Merrick A. Bedford

Theses and Dissertations

This thesis investigates the USMEPCOM’s issue of modeling and engineering Business Intelligence data centralized around the MEPS of Excellence (MOE) program. MEPS around the US conduct military personnel in-processing and in doing so have a vested interest in the standardization and application of the data associated with such processes. There are currently 65 MEPS stations and one RPS that handle military personnel onboarding paperwork and make determinations for military eligibility. This topic is important due to the MEPS cloud data processing system modernization efforts requiring data processing adaptation to ensure relevant and meaningful usage of current data.

Federated Medical Scoring Systems, Jacob F. Bryant

Theses and Dissertations

Federated Learning (FL) is a recent framework of machine learning implementation that trains models on a distributed network of clients as opposed to housing and analyzing this data centrally. This has data communication and practical data privacy advantages, the latter of which is particularly attractive to the medical community where patient privacy is closely safeguarded. We apply FL to a family of sparse linear integer models called Medical Scoring Systems (MSSs). We create a novel methodology for creating these MSSs in a simulated federated environment that involves an lo constrained Logistic Regression (LR), loss-surface examination, and rounding procedure. We tested …

Examining The Effect Of Contractor Logistics Support On The Reliability Of Military Aircraft, Rodrigo S. Campos De Moura

Theses and Dissertations

This study utilizes survival analysis for examining the effect of Contractor Logistics Support (CLS) on the reliability of military aircraft before and after implementing CLS. The provider of CLS in this study is the original equipment manufacturer that designed and produced the target aircraft of this study, the Embraer A-29 Super Tucano.

2033 Digital Modernization At Usmepcom: A Strategic Analysis Of Future Military Applicant Processing, William A. Clay

Theses and Dissertations

This research examines the projected 2033 applicant processing scenario considering the digital modernization efforts of the United States Military Entrance Processing Command (USMEPCOM). The study evaluates the necessary modifications to current processes, with a particular focus on the influence of two key information technology systems, the MEPCOM Integrated Resource System (MIRS) 1.1 and the Military Health System (MHS) Genesis, on manpower at a Military Entrance Processing Station (MEPS). In doing so, the study establishes baseline processing metrics for assessing these impacts. By utilizing discrete event simulation modeling and leveraging current literature, the study proposes strategies for incorporating technological advancements into …

Federated Analysis Of Wearables Data For United States Air Force Mental And Physical Readiness, Sung Yong O

Theses and Dissertations

This thesis investigates the use of machine learning and deep learning models within a federated learning framework to predict physical and mental readiness in military personnel, using wearable technology data. The collaboration with the 711th Human Performance Wing’s STRONG Lab highlights the importance of readiness as emphasized by the National Defense and Security Strategies. The study evaluates various predictive models, incorporating federated learning to ensure data privacy and security in healthcare systems. By analyzing a comprehensive dataset, the research aims to contribute to military readiness enhancement through technological advancements, supporting health and wellness initiatives to bolster the effectiveness of military …

Knowledge Management Modeling And Decision Analysis For Usmepcom, Luke G. Wunderlich

Theses and Dissertations

This thesis explores the adoption of Value-Focused Thinking (VFT) in enhancing the Knowledge Management (KM) program at USMEPCOM, aiming to align decision-making with the organization’s values and goals. Through evaluating the current knowledge flow and policy drafts, it proposes categorizing command messages, establishing a centralized information repository, and scheduling a daily order release to improve information accessibility and operational readiness. Although no alternative offers a perfect solution, implementing Command Message Categorization is expected to significantly enhance operational efficiency and prepare USMEPCOM for future challenges.

Long-Term Deterioration And Investment Modeling Of Water Distribution Infrastructure, Bethany M. Dorian

Theses and Dissertations

The United States Air Force (USAF) and municipal utilities rely on asset management processes to maximize utility of infrastructure assets while decreasing maintenance and repair costs. One of the core tenants of asset management is assessing the condition of the asset, which for water distribution pipes is challenging and costly to obtain. As a result, asset managers often rely upon pipe deterioration modeling using existing data, filling in the gaps when assessments are not available. This thesis uses USAF water distribution network data to develop a series of time-homogenous Markov chain probability models based on two sampling methods and four …

Advanced Oxidation Of Tert-Butanol With Ultraviolet Light Emitting Diodes And Hydrogen Peroxide, Lauren R. Mainolfi

Theses and Dissertations

Tert-butanol (TBA), a versatile chemical widely used in industrial processes, poses exposure risks through inhalation, ingestion, and skin contact. Environmental contamination, often from industrial activities, emphasizes the importance of robust waste management and monitoring to protect water supplies from potential TBA migration and ensure drinking water safety. This study employed hydrogen peroxide (H2O2): TBA molar ratios of 100, 200, 400, and 500:1 in a Continuous Flow Stirred-Tank Reactor (CSTR) with UV-LED as the TBA degradation mechanism in an Advanced Oxidation Process (AOP). The UV-LEDs and H2O2 were synergistically employed to generate hydroxyl radicals in an advanced oxidation process. Gas chromatography–mass …

Retrospective Cohort Study Of Pure Tone Audiometry Hearing Changes From Ototoxic Metalsand Solvents, Continuous Noise, And Impulse Noise Exposures At Hill Air Force Base From 2005 To 2019, Zachary I. Johnson

Theses and Dissertations

This retrospective cohort epidemiological study investigated the relative risks of hearing loss associated with ototoxicants in combination with noise exposure. Utilizing Department of Defense (DoD) industrial hygiene and hearing conservation data, this research expanded on a 2020 thesis conducted on Tinker Air Force Base (AFB), applying a similar methodology to Hill AFB, adding 893 evaluated individuals. Grouped into twelve exposure combinations with a minimum of three years of exposure duration, the study assessed various hearing loss indicators, including DoD Standard Threshold Shift (STS) and NIOSH STS. Ototoxic substances consistently elevated relative risk (RR) compared to noise-only exposure groups, but none …