Digital Commons Network^™

Comprehensive Analysis Identifies Variability In Pi3k Pathway Alterations In Triple-Negative Breast Cancer Subtypes, Reva K Basho, Li Zhao, Jason B White, Lei Huo, Roland L Bassett, Elizabeth A Mittendorf, Alastair Thompson, Jennifer K Litton, Naoto Ueno, Banu Arun, Bora Lim, Vicente Valero, Debu Tripathy, Jianhua Zhang, Beatriz E Adrada, Lumarie Santiago, Elizabeth Ravenberg, Sahil Seth, Clinton Yam, Stacy L Moulder, Senthil Damodaran

Faculty, Staff and Student Publications

Purpose: The PI3K pathway is frequently altered in triple-negative breast cancer (TNBC). Limited cell line and human data suggest that TNBC tumors characterized as mesenchymal (M) and luminal androgen receptor (LAR) subtypes have increased incidence of alterations in the PI3K pathway. The impact of PI3K pathway alterations across TNBC subtypes is poorly understood.

Methods: Pretreatment tumor was evaluated from operable TNBC patients enrolled on a clinical trial of neoadjuvant therapy (NAT; A Robust TNBC Evaluation fraMework to Improve Survival [ClinicalTrials.gov identifier: NCT02276443]). Tumors were characterized into seven TNBC subtypes per Pietenpol criteria (basal-like 1, basal-like 2, immunomodulatory, M, mesenchymal …

Watching The Fall Of Roe V Wade: Media Exposure Relates To Us Women's Alcohol Use Intentions, Stacy M Post, Mary C Jobe, Arianne N Malekzadeh, Katarina E Aubuchon, Rebecca K Hoffman, Michelle L Stock, Lisa Bowleg

Faculty, Staff and Student Publications

OBJECTIVE: The Supreme Court of the United States’ decision in Dobbs v. Jackson Women’s Health Organization in June 2022 overturned Roe v. Wade and ended federal protection of abortion rights. Given the drastic policy changes as a result of the ruling and high exposure to media related to abortion, women opposed to the decision may have experienced distress, which could trigger maladaptive coping strategies, such as alcohol use. The present research examined how consuming abortion-related media in the weeks following the Dobbs decision impacted alcohol use intentions among women of reproductive age residing in the 13 “trigger law” states that …

Management Of Incomplete Microcirculatory Reperfusion After Endovascular Thrombectomy: Focus On Inhibition Of The Glycoprotein Iib/Iiia Receptor Pathway, Neeharika Krothapalli, Thomas Ortel, Devin Mcbride, Adam De Havenon, Lauren H Sansing, David Hasan, Brian Mac Grory

Faculty, Staff and Student Publications

Endovascular thrombectomy (EVT) is one of the most effective therapies for acute ischemic stroke attributable to large-vessel occlusion but, despite successful treatment, there remains a significant number of patients with disability. The phenomenon of incomplete microcirculatory reperfusion or no reflow is thought to underlie a substantial proportion of cases with unfavorable outcome. This phenomenon likely arises from platelet aggregation and endothelial edema impacting the cerebral microvasculature, vessels that are below the resolution of digital subtraction angiography. Although incomplete microcirculatory reperfusion prevents tissue recovery and poses a significant clinical challenge, there are multiple therapeutic options administered early after recanalization that have …

Outcomes In 14 Live Births Resulting From Pegvaliase-Treated Pregnancies In Pku-Affected Females, Caide Bier, Kaelin Dickey, Brittan Bibb, Angela Crutcher, Rebecca Sponberg, Richard Chang, Monica Boyer, Laura Davis-Keppen, Cindy Matthes, Michelle Tharp, Danielle Vice, Erin Cooney, Megan Morand, Joseph Ray, Melissa Lah, Markey Mcnutt, Hans C Andersson

Faculty, Staff and Student Publications

Background: Adults with PKU have difficulty maintaining plasma phenylalanine (Phe) in the range that is safe for neurologic function. Elevated plasma Phe is a risk factor for congenital anomalies and developmental delay in offspring resulting from pregnancies with poor Phe control in women with PKU. Enzyme supplementation with pegvaliase allows adults with PKU to eat an unrestricted diet and have plasma Phe levels in a safe range for pregnancy but pegvaliase has not been approved for use in pregnant females with PKU. We report the results of chart review of 14 living offspring of females affected with PKU who were …

Portraits Of Hispanic And/Or Latino Leadership Development In The Military, Michael Lugo

Electronic Theses and Dissertations

Abstract

The study presented denotes a continuous transition among the Hispanic and/or Latino demographics in the military and the cadet accounts of military inequality incidents while in the military (Cabrera et al., 2017; Eckel & King, 2004). To assist Hispanic and/or Latino needs based on demographics and environment (National Center for Education Statistics, 2019). Military leaders contribute to growing a diverse, inclusive, and equitable military force for all ethnic groups. The Department of Defense (DoD) is the most racially and ethnically diverse workplace in the United States (Daniel et al., 2022). Nevertheless, racial/ethnic harassment and discrimination in the military continue …

Foraminifera As A Model Of Eukaryotic Genome Dynamism, Caitlin Timmons, Kristine Le, H. B. Rappaport, Elinor G. Sterner, Xyrus X. Maurer-Alcaláh, Susan T. Goldstein, Laura A. Katz

Biological Sciences: Faculty Publications

In contrast to the canonical view that genomes cycle only between haploid and diploid states, many eukaryotes have dynamic genomes that change content throughout an individual’s life cycle. However, the few detailed studies of microeukaryotic life cycles render our understanding of eukaryotic genome dynamism incomplete. Foraminifera (Rhizaria) are an ecologically important, yet understudied, clade of microbial eukaryotes with complex life cycles that include changes in ploidy and genome organization. Here, we apply fluorescence microscopy and image analysis techniques to over 2,800 nuclei in 110 cells to characterize the life cycle of Allogromia laticollaris strain Cold Spring Harbor (CSH), one of …

Attrition And Turnover Intentions Of Paramedic Program Directors In The State Of Texas, Jacob Charles Braddock

Electronic Theses and Dissertations

Prehospital care currently finds itself in a critical crisis as the number of emergency medical technicians continues to decline nationwide. This is especially alarming as such shortages have been exacerbated in the wake of the COVID-19 pandemic. Emergency medical service agencies are looking to educational institutions to ensure that an adequate number of providers are entering the field. These institutions are led by program directors, who oversee all aspects of the program. However, these individuals are also leaving the role at alarming rates nationwide. The purpose of this action research study was to take a qualitative descriptive approach to explore …

What The Future Looks Like: Heralding The Unique Missions Of Translational Issues In Psychological Science, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

No abstract provided.

Safety And Efficacy Of Mechanical Aspiration Thrombectomy For Patients With Acute Lower Extremity Ischemia, Alex Powell

All Publications

Objective: Acute limb ischemia (ALI) is associated with high rates of amputation and consequent morbidity and mortality. The objective of this study is to report on the safety and efficacy of aspiration thrombectomy using the Indigo Aspiration System in patients with lower extremity (LE) ALI.

Methods: The STRIDE study was an international, multicenter, prospective, study that enrolled 119 participants presenting with LE-ALI. Patients were treated firstline with mechanical thrombectomy using the Indigo Aspiration System, before stenting or angioplasty, or other therapies as determined by treating physician. The primary end point was target limb salvage at 30 days after the procedure. …

Development Of Customized Mips_32 Core Processor For Image Processing Applications, Omar Nowfal Mohammedtaher, Mohammed Najm, Hassan Awheed Jeiad

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Definitely, image processing operations without advanced and expensive microprocessors consume more time, power, and larger programs. So, improving the reasonable cost of microprocessors is crucial in this situation. This paper proposes an improvement for the MIPS_32 architecture that is called a Customized MIPS_32 (CMIPS_32) to enhance the capabilities of image processing (IP) operations. The proposal aims to increase throughput by minimizing the iterative fetching of instructions required by a certain IP operation into a single customized IP instruction. The architecture of MIPS_32 was developed in two phases. Firstly, the Register File, control unit, and ALU are modified to manipulate the …

Reproductive Biology Of The Jellyfish Outbreak Along The Uae Coastal Waters, Amrutha Aravind

Dissertations

Jellyfish are a ubiquitous occurrence in the world’s oceans. During the past decades, dramatic spatial increases and temporal shifts in jellyfish distributions have been reported around the world. The United Arab Emirates (UAE) coastal area also has experienced several blooms along with severe adverse impacts on its economic facilities. Few studies have been conducted within the Arabian Gulf and the Sea of Oman, to identify the blooming species and the environmental parameters that favor such breakouts. The present study aimed to identify the jellyfish species found along the coastal area of UAE and trying to link their occurrence with seasonal …

A Visual And Spatial Tool For Tracking, Mapping And Forecasting The Dispersal Of Biological Control Agents, Komi Mensah Agboka, John Odindi, Elfatih M. Abdel-Rahman, Onisimo Mutanga, Henri E.Z. Tonnang

All Peer-Reviewed Publications

iPydisp is an open-source, Python-based tool designed to model the spatio-temporal dispersal of insect species such as parasitoids. It provides an accessible interface for interactive spatio-temporal analysis, using cellular automata algorithms for easy data processing and updates. The tool's main features include intuitive data loading, easy setting of dispersal constraints, and dynamic visualization of dispersal patterns. iPydisp has the potential to improve our understanding of parasitoid dispersal and enhance pest management strategies.

Trinity Western University Decisions And Engineers’ Equity, Diversity, And Inclusion Obligations Under The Statutory Public Interest Mandate, Michelle Liu, Vanessa Matta

Canadian Journal of Law and Technology

Engineers create technologies but do not sufficiently care for their biased and inequitable outcomes despite the engineering profession’s statutory mandate to protect the public interest. The engineering and legal professions’ similar admission processes and statutory provisions mandating the protection of public interest may justify applying the Supreme Court of Canada’s interpretation of the legal profession’s public interest mandate in the Trinity Western University decisions to the engineering profession. The Supreme Court’s interpretation centres on equal access to the profession, diversity within its membership, and protection of 2SLGBTQ+ persons. The work begins by setting out the definitions and challenges of equity, …

Knowledge Gaps About Micronutrient Deficiencies In Tanzania And The Effect Of Information Interventions, Pius Kilasy, Brandon R. Mcfadden, Kelly A. Davidson, Leah H. Palm-Forster

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Reducing micronutrient malnutrition (“hidden hunger”) in low-income countries is a global challenge, particularly among women, children, and high-poverty households. Countries like Tanzania have developed diverse strategies to combat malnutrition, including the biofortification of staple foods. However, broad awareness and knowledge of micronutrient deficiencies and beneficial foods are needed for these strategies to be effective. The objectives of this study were to (i) examine Tanzanian consumers' initial awareness and knowledge of deficiencies for four micronutrients and associated biofortified foods, and (ii) to examine the effectiveness of targeted communication approaches (i.e., information and branding) to improve knowledge. Data were collected from 1029 …

The Pacifican March 2024, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

A Survey Analysis On Family Leave Policies And Experiences Among Medical Trainees And Attending Physicians, Kristina Rozova Md, Shanika Esparaz, Meghana Chalasani, Michelle Tran, Anuk Burli

USF-LVHN SELECT

No abstract provided.

From Ordering To Taking It: Pre-Exposure Prophylaxis (Prep) Uptake Among At-Risk Youth In An Area Of High Hiv Prevalence, Jared Stillman Md, Claudia Espinosa, Emily Coughlin

USF-LVHN SELECT

No abstract provided.

Equity—Access To Menstrual Products As A Social Determinant Of Health, Rosalie Mattiola Md, Sejal Jain Md, Samantha Finkelstein Md, Fawaz Hussain Md, Clara Freedman Md, Berwin Yuan Md, Brett O'Donnell Md, Nicole M. Burgess Bs, Autumn Kieber-Emmons Md, Mph, Ashwini Kamath Mulki Md, Mph

USF-LVHN SELECT

No abstract provided.

Evaluation Of A Flipped Classroom Model For An Introduction To Point Of Care Ultrasound Intern Resident Course, Jessica Chuang Md, Andrew Ferdock Bs, Kevin R. Roth Do, Facoep, Claire L. Paulson Do, Hanna R. Warren Do, Phillip M. Grenz Do, Christopher Connell Do, Anita Kurt Phd, Rn, Marna R. Greenberg Do, Mph, Facep, Kristine L. Schultz Md

USF-LVHN SELECT

No abstract provided.

Early Knee Range Of Motion Following Operative Treatment For Tibial Tubercle Avulsion Fractures Is Safe, Kevin Huang Md, Nathan Houlihan, Alexandre Arkader, John Flynn, Brendon Williams

USF-LVHN SELECT

No abstract provided.

Measuring Timeliness Of Responses To Stat Neurosurgical Trauma Consults At Lehigh Valley Hospital - Muhlenberg, Amanda Brisco Md, Joseph J. Stirparo Md, Bree A. Harrison Bsn, Rn, Tcrn, Jaclyn Sharkazy Pa-C, Mspas, Emily Bear Bsn, Rn, Ccrn, Tcrn

USF-LVHN SELECT

No abstract provided.

The Incidence And Mortality Of Ocular Melanomas, Haider Ghumman, Alex Weppelmann

USF-LVHN SELECT

No abstract provided.

Hospitalization Trends Of Fractures Presenting To The Emergency Room From 2009 To 2021, Jacob Albers Md, Jeffrey B. Brown Md, Maykel Dolorit, Lauern Ladehoff Md, Ambuj Kumar, Robert P Wessel Md

USF-LVHN SELECT

No abstract provided.

Pre-Stimulus Bioelectrical Activity In Light-Adapted Erg Under Blue Vs. White Background, Katherine Tsay Md, Sara Safari Md, Abdullah Abou-Samra, Jan Kremers, Radouil Tzekov

USF-LVHN SELECT

No abstract provided.

The Professional Constructor, Full Issue, Volume 49, Number 01

The Professional Constructor

No abstract provided.

Mixed Reality For In-Field Construction Activities: A Systematic Literature Review To Identify Challenges And Solutions, Sumanth Sai. P., Jason Lucas

The Professional Constructor

With the new industrial revolution, “Industry 4.0,” it is important to understand and incorporate the new standards and technologies evolving in the market. Industry 4.0 relies on the integrated use of big data and analytics coupled with various technologies to help make decisions and manage projects. This revolution has brought Mixed Reality (MR) into the construction field. Mixed reality (MR) offers significant benefits for smart industries, such as enhancing productivity, training, manufacturing, error correction, assembly, and packaging processes. But how feasible are Mixed Reality Technologies (MRTs) considering the high initial investment required for acquiring devices, subscribing to services, planning and …

“Guard Your Virtue With Your Life”: Purity Expectations And Dynamics Of Purity And Gender-Based Violence For Latter-Day Saint (Lds) Girls And Women, Reilly H. Brady

Women, Gender, and Sexuality Studies Senior Honors Papers

This study investigates purity expectations directed towards girls and women in the Church of Jesus Christ of Latter-day Saints (LDS), approaching a largely underresearched topic and establishing findings such as the mutual embeddedness of purity and gender-based violence for girls and women in the LDS Church. Through a discourse analysis, this study creates a historical timeline of over 100 years of documents, including church-produced media as well as separate writings by LDS women, focusing on how purity has changed and has been politicized over time within various historical moments. While most survey participants in this study described never having heard …

Left Ventricular Ejection Fraction And The Future Of Heart Failure Phenotyping, Matthew G Dimond, Nasrien E Ibrahim, Mona Fiuzat, John J V Mcmurray, Joann Lindenfeld, Tariq Ahmad, Biykem Bozkurt, Michael R Bristow, Javed Butler, Peter E Carson, G Michael Felker, Mariell Jessup, Jaime Murillo, Toru Kondo, Scott D Solomon, William T Abraham, Christopher M O'Connor, Mitchell A Psotka

Faculty, Staff and Students Publications

Heart failure (HF) is a complex syndrome traditionally classified by left ventricular ejection fraction (LVEF) cutpoints. Although LVEF is prognostic for risk of events and predictive of response to some HF therapies, LVEF is a continuous variable and cutpoints are arbitrary, often based on historical clinical trial enrichment decisions rather than physiology. Holistic evaluation of the treatment effects for therapies throughout the LVEF range suggests the standard categorization paradigm for HF merits modification. The multidisciplinary Heart Failure Collaboratory reviewed data from large-scale HF clinical trials and found that many HF therapies have demonstrated therapeutic benefit across a large range of …

Environmental Justice: A Missing Core Tenet Of Global Health, Redeat Workneh, Merhawit Abadi, Krystle Perez, Sharla Rent, Elliott Mark Weiss, Stephanie Kukora, Olivia Brandon, Gal Barbut, Sahar Rahiem, Shaphil Wallie, Joseph Mhango, Benjamin C Shayo, Friday Saidi, Gesit Metaferia, Mahlet Abayneh, Gregory C Valentine

Faculty, Staff and Students Publications

No abstract provided.

Performance Characteristics Of Sepsis Screening Tools During Delivery Admissions, Elliott K Main, Matt Fuller, Vesela P Kovacheva, Rania Elkhateb, Kristen Azar, Morgan Caldwell, Vanna Chiem, Mindy Foster, Ronald Gibbs, Brenna L Hughes, Rebecca Johnson, Nobin Kottukapally, Magdalena Sanz Cortes, Melissa G Rosenstein, Laurence E Shields, Sylvia Sudat, Caitlin D Sutton, Paloma Toledo, Austin Traylor, Kurt Wharton, Melissa E Bauer

Faculty, Staff and Students Publications

Objective: To evaluate the screening performance characteristics of existing tools for the diagnosis of sepsis during delivery admissions.

Methods: This was a case-control study using electronic health record data, including vital signs and laboratory results, for all delivery admissions of patients with sepsis from 59 nationally distributed hospitals. Patients with sepsis were matched by gestational age at delivery in a 1:4 ratio with patients without sepsis to create a comparison group. Patients with chorioamnionitis and sepsis were compared with a complete cohort of patients with chorioamnionitis without sepsis. Multiple screening criteria for sepsis were evaluated: the CMQCC (California Maternal Quality …