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Exploring The Effects Of Amniotic Bladder Therapy On Female Sexual Dysfunction In Interstitial Cystitis/Bladder Pain Syndrome Patients, Jonathan D. Lutchka, Jack Vercnocke Md, David Pearlman Md, Aron Liaw Md, Nivedita Dhar Md

Medical Student Research Symposium

Introduction and Objectives: Female sexual dysfunction (FSD) is commonly associated with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). FSD manifests as abnormalities in sexual desire, arousal, orgasm, pain, distress, and satisfaction. Our primary objective was to assess the impact of micronized amniotic membrane injections (AM) on FSD and lower urinary tract symptoms using comprehensive measures, including the multi-domain Female Sexual Function Index (FSFI), the Pain Visual Analog Scale (VAS), and the Interstitial Cystitis Symptom Index (ICSI) and Interstitial Cystitis Problem Index (ICPI).

Methods: Study participants included patients diagnosed with IC/BPS and FSD refractory to traditional therapies. Under general anesthesia, these …

Flash Radiation Ultra-High Dose Rate Radiation With Potential For Sensitization By Platinum, Abigail A. Jaczkowski, Stephen Brown Ph.D.

Medical Student Research Symposium

External beam radiation therapy, a cornerstone in cancer treatment for 50% of patients, poses challenges due to its toxicity to both cancer and healthy cells. Seeking to mitigate side effects, the emerging FLASH radiation technology employs ultra-high dose rates, promising quicker treatments with reduced impact on surrounding normal tissue. Platinum, recognized as a radiation sensitizer, enhances the effectiveness of radiation therapy by increasing sensitization at higher energy levels through pair-production.

This study explores the hypothesis that Cisplatin, a platinum-based chemotherapy agent, will exhibit a synergistic effect when combined with FLASH radiation. Using A549 cells from non-small cell lung cancer, the …

The Efficacy And Frequency Of Early Left Heart Catheterization After Out Of Hospital Cardiac Arrest Over The Last Decade, Shobi Mathew, Robert Welch, Robert Swor, Robert R. Ehrman, Anthony Lagina, Brian O'Neil

Medical Student Research Symposium

Introduction:

The efficacy of early coronary intervention after return of spontaneous circulation (ROSC) from out of hospital cardiac arrest (OHCA) is debated. We aimed to nationally study the effect of early LHC on survival with good neurological outcome and describe the rate and timing of LHC in OHCA.

Methods:

The observational study included patients enrolled in the national CARES registry from 2013-21. Outcome was cerebral performance category, (CPC) (good <3 vs. poor > 3) at hospital discharge. For the outcome of LHC by year, chi square analysis was performed. A propensity score (PS) model was constructed using variables predictive of LHC and good outcome …

Exploring The Relationship Of Varying Hydrocephalus Severity On Csf Dynamics In A Pediatric Hydrocephalus Rodent Model, Parker R. Fitzgerald, Grant Zydeck, Jeff Horbatiuk, Enoch Kim, Arjun Muralidharan, Carolyn A. Harris Phd

Medical Student Research Symposium

Hydrocephalus causes neurological effects and high intracranial pressure (ICP) in the pediatric condition. Studies observing the relationship between ICP and cerebrospinal fluid (CSF) production in an electrical resistance model have been performed, but less has been done to define this relationship in living organisms. This study explored CSF flow dynamics as a consequence of hydrocephalus severity utilizing a novel model.

The model induced hydrocephalus in rats through injecting 30-50 micrometers of 25% (w/v) kaolin into the cisterna magna to obstruct CSF outflow. After 15-16 days of acclimation, the rats were anesthetized with isoflurane. A Transonic SP200 pressure transducer was inserted …

A Pilot Study Assessing The Efficacy Of Amniotic Bladder Therapy In Spinal Cord Injury Patients With Female Sexual Dysfunction, Kyle P. O'Hollaren, Emma Ross, Codrut Radoiu, Lincoln Erickson, Michael Bush-Arnold, Ali Bitar, Steven Lucas, Nivedita Dhar

Medical Student Research Symposium

Introduction and Objectives: Female sexual dysfunction (FSD) following spinal cord injury (SCI) presents with abnormalities in sexual desire, arousal, orgasm, pain, distress, and dissatisfaction. FSD negatively impacts quality of life and is often refractory to available treatment options. Previously, we reported preliminary benefits of intra-detrusor micronized amniotic membrane (AM) on detrusor dysfunction following SCI. In this study, we evaluated the effect of intra-detrusor micronized AM injection on FSD symptoms in SCI patients using the multi-domain female sexual function index (FSFI) and pain visual analog scale (VAS).

Methods: Five SCI females (mean age: 32 ± 12 years) with FSD recalcitrant to …

Examining Vaccine Hesitancy Trends In An Underserved Population At A Student-Run Free Clinic, John Pum, Cameron Bear, Dhiraj Tadikamalla, Hasti Nema

Medical Student Research Symposium

Title: Examining Vaccine Hesitancy Trends in an Underserved Population at a Student-Run Free Clinic

Authors: John Pum, Cameron Bear, Dhiraj Tadikamalla, Hasti Nema, Robert Sherwin M.D.

Introduction:

The global debate surrounding the safety and efficacy of COVID-19 vaccines has triggered widespread vaccination hesitancy, impacting not only COVID-19 immunizations but also other vaccines. This study investigates whether a parallel trend exists within a Student-Run Free Clinic (SRFC), focusing on an underserved population disproportionately affected by the pandemic.

Methods:

Retrospective analysis was conducted by coordinators of Cass Clinic, a Detroit-based SRFC. Patients included were individuals 18 or older who received the influenza …

Six- Month Report Assessing The Feasibility And Effectiveness Of Amniotic Bladder Therapy In Patients With Chronic Radiation Cystitis, Samy Shelbaya, Raghav Madan, Nick Pryde, Jack Vercnocke, Codrut Radoiu, Julian Julian Jeberaeel, Nitin Vaishampayan, Nivedita Dhar

Medical Student Research Symposium

Introduction: In view of the pathophysiology of chronic radiation cystitis (CRC) that is mainly caused by activation of an inflammatory cascade leading to chronic inflammation, vascular damage and fibrosis, amniotic membrane (AM) based therapy has emerged as a potential therapeutic approach for radiation-induced tissue injury due to its immunomodulatory, vasculogenic and anti-fibrotic properties. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory CRC patients for up to 3 months. Herein, we evaluated the durability of ABT up to 6 months.

Methods: CRC patients recalcitrant to multiple therapies were eligible for the study and …

“It's The Commonwealth's Attempt To Censor . . . What We Teach”: Anti-Lgbtqia2s+ Educational Policy Influences On Rural Secondary Ela Teacher Practices, Josh Thompson, Clint Whitten, Karin Kaerwer

Virginia English Journal

The shift in political landscape in Virginia from former Democratic Governor Ralph Northam to current Republican Governor Glen Youngkin influenced educational policies in the commonwealth. Waving the banner of parental rights, the Youngkin administration began targeting LGBTQIA2S+ students and educators through legislation and policies such as SB 656 and Model Policies on Ensuring Privacy, Dignity, and Respect for All Students and Parents in Virginia’s Public Schools. To understand the influence on rural school districts, this study asked how rural secondary English Language Arts educators understand and respond to these anti-LGBTQIA2S+ policies as well as the ways in which those educators …

Preventing And Responding To Workplace Violence In The Emergency Department, Stefanie Lai, Alicia Rodriguez

Providence Nursing Research Conference 2023 – Present

Background: Workplace violence (WPV) is defined as physical violence or verbal threats of physical violence, regardless of whether an employee sustains an injury. Emergency department (ED) staff are at high risk of exposure to WPV, which can lead to burnout, job dissatisfaction, and secondary stress. Effective preparation for and response to WPV incidents can help mitigate these negative effects. Multicomponent interventions, including education, safety huddles, behavioral health rapid response teams, and environmental modifications, have been shown to reduce WPV incidents and increase staff perceptions of safety.

Purpose: The purpose of this evidence informed-quality improvement project was to increase knowledge of …

Peer-To-Peer Model To Educate And Spread Awareness Of Vaccines In Detroit, Sofia Howson, Jennifer Schmidt, Catherine Maples, Jack Mcconnell, Soham Desai, Rebekah Pitpitan, Teena Chopra, Matthew W. Seeger

Medical Student Research Symposium

Since the COVID-19 pandemic, national vaccination rates show a dangerous decline with Detroit being amongst the lowest with only 41.3% of adolescents completing the vaccine series. The Vaccine Ambassador program was created to mitigate the decline in vaccination rates through the education and empowerment of youth via train-the-trainer model of education.

The program was implemented over the course of two years with a total of 28 high school students who received education on the history and mechanism of vaccines, herd immunity, and how to effectively communicate. The program was created in collaboration with physicians in Infectious Diseases and a professor …

Active Surveillance Vs. Curative Treatment: Longitudinal Quality Of Life 2-Years After Low-Risk Prostate Cancer Diagnosis, Emma Streveler, Cathryn Bock, Jinping Xu, James Janisse, Justin Woo

Medical Student Research Symposium

Background: Active surveillance (AS) allows patients with low-risk prostate cancer (LRPC) to be monitored for disease progression, thereby avoiding or delaying invasive curative treatment (CT) (i.e., surgery or radiation) and related side effects. Here we compare quality of life (QOL) two-years after diagnosis between men who underwent CT overall and by race.

Methods: Black and white men with LRPC were recruited through population-based cancer registries in metropolitan Detroit and Georgia. Participants were grouped by their treatment type (CT or AS). QOL measures SF-12 and EPIC-26 were assessed at baseline and 2-year follow up using mailed surveys. Differences between groups at …

Analysis Of Antibody Drug Conjugate On Cellular Senescent Human Glioblastoma, Ariel P. Walker, Renee Hirte, Cecile Riviere-Cazaux, Authur Warrington, Terry Burns

Medical Student Research Symposium

Background: Glioblastoma Multiforme (GBM) is an aggressive and malignant brain tumor known for its rapid progression and unfavorable prognosis. The standard treatment options primarily involve radiation and temozolomide, however recurrence is inevitable.

B7H3/CD276, an immunomodulatory transmembrane glycoprotein, demonstrates tumor-specific expression, with limited presence in normal healthy tissue, making it a promising and attractive treatment target in GBM. AbbV155 is an antibody drug conjugate that inhibits BCL-XL and specifically targets B7H3 (CD276) on GBM cells with the goal of selectively eliminating viable tumor cells.

Objectives: First, we sought to confirm the presence of B7H3/CD276 in our selected cell line via …

Racial Differences In Cirrhosis Etiology And Manifestation In A Predominately African American Urban Medical Center, Gokturk N. Tepe, Paul Naylor

Medical Student Research Symposium

No abstract provided.

P2y2 Inhibition Modifies The Anabolic Response To Exercise In Adult Mice, Nickolas Vinokurov, Devin Mendez, Amit Chougule Dr, Chunbin Zhang, Joseph Gardinier Dr

Medical Student Research Symposium

Osteocytes serve as a sensory network that responds to dynamic loading of the skeleton and play a crucial role in regulating bone mass while maintaining bone quality [1]. Osteocytes’ induction of bone formation in response to loading is extremely age dependent, such that clinical studies have shown exercise to be less and less effective as we age [2,3]. As a result, modifying osteocytes’ mechanosensitivity may enable older adults to better capitalize on the anabolic nature of exercise to increase bone mass and reduce fracture risk. Based on our previous work, P2Y2 activation down-regulates the mechanosensitivity of bone cells by increasing …

Insular And Amygdala Origin Seizures: Unmasked With Electrocorticography (Ecog), Younes Motii, Arichenaramanathan Manmatharayan, Parthasarathi Chamiraju, Mona Elsayed

Medical Student Research Symposium

Insular and Amygdala Origin Seizures: Unmasked with Electrocorticography (ECOG)

Introduction:

Insula and amygdala have a large network of connections to other cortical regions. Seizures originating from these structures may become evident only after propagation to other structures. High degree of attention must be paid to auras and seizure semiology in patients with medically intractable epilepsy.

Methodology:

We have described a series of three adult male patients with focal intractable epilepsy who did not have structural lesions on Magnetic Resonance Imaging (MRI). Patients underwent MRI, Positron Emission Tomography (PET) scan, scalp electroencephalography (EEG), and stereo EEG implantation.

Results:

All three patients …

Enhancing Patient Understanding: The Impact Of Educational Videos On Ophthalmology Visits, Anna Zhao

Medical Student Research Symposium

A major component of effective patient-centered care is the patient’s understanding of their health condition and treatments. Increased knowledge of medical conditions can positively modify health behaviors, such as more participation in cancer screening and better adherence to medications. However, the readability of educational materials often does not match the patients’ reading abilities. Instead, educational videos, which have gained prominence with the emergence of tele-visits following COVID-19, have shown promise in being beneficial to patients with lower literacy levels. For ocular pathologies, early identification and care are key in preventing vision loss. Tele-education in ophthalmology could increase patient awareness of …

Exploring The Neural Correlates Of Mindfulness-Based Interventions In Youth, Jovan Jande, Clara Zundel, Samantha Ely, Sneha Bhargava, Carmen Carpenter, Reem Tamimi, Leah Gowatch, Mackenna Shampine, Emilie-Clare O'Mara, Shravya Chanamolu, Hilary Marusak

Medical Student Research Symposium

Mindfulness based interventions (MBI) reduce the severity of anxiety and depression among a variety of populations. While the psychological benefits of MBIs are increasingly recognized, less is known about the underlying neural correlates—particularly during childhood and adolescence, a time when many psychopathologies begin to emerge. Here, we provide the first systematic review on the neural correlates of MBI in youth. We reviewed the PubMed database for original articles examining the neural correlates of MBI in youth (0-18 years) leveraging neuroimaging. The search yielded 331 studies, of which 13 were included in the review. These studies comprised 451 participants and were …

Bone Fractures With And Without Sickle Cell Disease In The Pediatric Population, Alexander Wind, Lilian Awad, David Merolla, Alexander Glaros, Ahmed Bazzi, Priya Spencer, Meghan Baske, Emily Ridge, Usha Sethuraman

Medical Student Research Symposium

Background: Individuals with sickle cell disease are restricted from certain physical activities due to the increased risk of complications including fractures secondary to osteopenia. However the exact incidence and outcomes of fractures amongst these patients is unknown.

Objectives: (1) describe the incidence, epidemiology, and outcomes of fractures in patients with SCD. (2) to compare fracture patterns and outcomes in patients with and without SCD.

Methods: This is a retrospective, cohort study of patients aged 0-25 years old with HbSS, HbSC, or HbS-β-thalassemia with a fracture evaluated at a pediatric emergency department from April 2009-April 2022. Eligible patients were identified using …

Vaccine Hesitancy Among Youth Living With Hiv In Detroit, Madeline B. Simone

Medical Student Research Symposium

Vaccine hesitancy among youth with human immunodeficiency virus (HIV) was evaluated to determine if the pandemic affected vaccine acceptance. A retrospective chart review was conducted to analyze vaccine rates over a five-year (pre-post COVID) in one university-based clinic. Results indicated a variation in acceptance rates between vaccines, with the MenACWY, MenB, tetanus, and HPV having the highest acceptance rates and COVID-19 and annual flu vaccine having the lowest acceptance rates. Vaccine hesitancy did not correlate with HIV treatment hesitancy nor with aversion to needles. Negative messaging around vaccines from a variety of sources appeared to be the primary factor in …

M-Chat Implementation Strategies To Improve Autism Screening Rates In Pediatric Clinics In Metro Detroit, Karamoja Monchamp

Medical Student Research Symposium

The Modified Checklist for Autism in Toddlers (M-CHAT) is the most widely used autism screening tool. However, current practices for M-CHAT roll-outs and follow-ups are not wide-reaching, culturally sensitive, or consistent. This study aims to address the existing barriers to universal autism screenings and design a sustainable implementation strategy for a successful M-CHAT roll-out. We implemented strategies in five Henry Ford Health pediatric clinics, incorporating iPad-administered M-CHAT in waiting rooms, multilingual options, task shifting for referrals, forced choice mechanisms, and audit-and-feedback support. A Clinical Screening Dashboard tracked real-time M-CHAT data, including demographic information, collected from EPIC. Our goal is to …

Hif Expression In Clear-Cell Renal Cell Carcinoma (Ccrcc) Tumors Of Adults With And Without Obstructive Sleep Apnea (Osa), Olivia Heppell, Carlos Guerra Londono, Nilesh Gupta

Medical Student Research Symposium

Introduction: Upregulation of hypoxia-inducible factors (HIF) is an important pathological feature shared by clear cell renal cell carcinoma (ccRCC) and obstructive sleep apnea (OSA). However, it is unclear whether OSA alters the pathogenesis of ccRCC via HIF expression.

Methods: A retrospective cohort of adults undergoing nephrectomy for ccRCC was identified electronically (IRB#16040-1). The diagnosis of OSA was established with preoperative STOP-BANG scores or polysomnography. A consecutive sample of 20 individuals with and 20 without OSA was selected. Clinical characteristics and pathology results were reviewed. Resected tumor sections were immunohistochemically stained for HIF-1& HIF-2 at antibody dilutions of 1:150. Intensity and …

Healthy Hearts: An Interactive Demonstration To Increase Interest In Medicine In Elementary/ Middle School Students In/Around Detroit., Neha Chava, Jessica Elderkin, Austin Kim, Molly Dahle, Rohit Goru, Karamoja Monchamp, Neeraj Ochaney, Meghan Dwaihy Md, Mph

Medical Student Research Symposium

There continues to be a lack of representation and diversity in higher education today, especially in medicine and healthcare. As part of the Healthy Hearts student organization at Wayne State University School of Medicine, we developed a one-time educational session and interactive demonstration to teach students about heart and lung health and fuel students’ enthusiasm for healthcare. This project serves as a quality improvement study to understand how we can increase STEM interest in elementary and middle school students in and around Detroit, Michigan. A three question pre- and post-intervention survey was constructed to measure change in: 1) interest in …

Exploring The Longitudinal Associations Between Diet And Heart Failure With Preserved Ejection Fraction Among Middle-Aged Adults In The Cardia Study, Meaghan Osborne, Dragana Komnenov

Medical Student Research Symposium

There is currently limited evidence for the use of pharmacotherapies for heart failure with preserved ejection fraction (HFpEF). Given that diet is a key health behavior, the purpose of this study was to explore dietary predictors of HFpEF among middle-aged adults. All data were obtained from the Coronary Artery Risk Development in Young Adults study, a longitudinal cohort study. We analyzed the data from males and females (n= 2505) who had (1) completed the diet questionnaire at year(Y) 20 of follow-up and (2) undergone Doppler scan at Y30. We then classified participants as having HFpEF or not using three separate …

Beyond Traditional Metrics: Assessing Value In Carpal Tunnel Surgeries, Trae M. Hill, Alex Lindahl, Megan C. Carulla, Emily Mazier, Charles S. Day

Medical Student Research Symposium

Beyond Traditional Metrics: Assessing Value in Carpal Tunnel Surgeries

Meet Patel¹, Emily Mazier², Megan Carulla¹, Trae Hill¹, Alex Lindahl², Charles S. Day³

¹Wayne State University, Detroit, MI, ²Oakland University William Beaumont, Auburn Hills, MI, ³Henry Ford Medical System, Detroit, MI

Introduction:

To control healthcare costs, one must consider cost-effectiveness and quality of care metrics. This study compares the value of carpal tunnel release (CTR) performed in the ambulatory surgical center (ASC) to the hospital outpatient department (HOPD).

Methods:

Costs were determined by the Time-Driven Activity-Based Costing …

Epithelial And Mesenchymal Olfactory Stem Cells Gathered With Minimally-Invasive Micro-Brush, Tyler Petersen

Medical Student Research Symposium

Spinal cord injury (SCI) causes devastating lifestyle and financial consequences for the patient. Treatment strategies emphasize neuroprotection, but not regeneration. In this regard, stem cells are an innovative field of study that has the potential to regenerate neural tissue, thereby increasing a person’s ability to regain function. The purpose of this project is two-fold: to attain olfactory stem cells located in the nasal canal in a minimally-invasive way and to gather neural cells from the epithelium and mesenchymal cells in the lamina propria. Cells were gathered with sterile nasal micro-brushes, stored, and grown in flasks. After cells reached confluency, they …

The Celebrity Effect: How Social Media Changed Ozempic Utilization By Medicaid Patients, Sara L. Ma Ms, Mihaela-Elena Rapolti Md

Medical Student Research Symposium

Background: Recently, glucagon-like peptide-1 receptor agonists (GLP-1 agonists), a drug class used to treat Type 2 Diabetes, has gained popularity on social media for cosmetic weight loss. Celebrity endorsement of Ozempic, brand name of GLP-1 agonist semaglutide, has increased public demand and caused supply shortages. However, effects on Medicaid patients, who use Ozempic for diabetes, have yet to be investigated.

Methods: We sourced publicly available drug utilization datasets from Medicaid.gov. Nationwide Medicaid reimbursement data for Ozempic, Wegovy (another brand name of semaglutide), and Jardiance (different diabetes medication drug class) were extracted for 2021, 2022, and 2023. Rates of change per …

Maximizing Value In Total Knee Arthroplasty: Ambulatory Surgical Center Or Hospital Outpatient Department?, Megan Carulla, Meet Patel, Emily Mazier, Alex Lindahl, Trae Hill, Charles S. Day

Medical Student Research Symposium

Introduction:

In the United States, healthcare costs have consistently ranked the highest among developed countries, leading to an urgent push towards decreasing spending. This study compared the cost of robot-assisted total knee arthroplasty (TKA) performed in a hospital outpatient department (HOPD) to an Ambulatory Surgical Center (ASC).

Methods and Materials:

Costs were determined using Time-Driven Activity-Based Costing (TDABC) methodology. All steps of a patient care pathway for robotic TKA performed in ASC and HOPD were organized into one process map. All personnel involved in patient care were included and the average time each allocated to patients was multiplied by their …

The Extent Of Medical Student Stigma In Healthcare Delivery To Populations Experiencing Homelessness Or With Substance Use Disorders, Adam Chaban, Maria Tjilos, Neil Garg, Saachi Mittal, Noor Sulaiman, Nedda Elewa, Nicole Ashley Hao, Roxanne A. Ilagan, Abhijay Kumar, Stephen Venable, Richard Bryce

Medical Student Research Symposium

Evaluating the significance of medical student bias towards people experiencing homelessness (PEH) and people who use drugs (PWUD) in Detroit, Michigan.

Of the estimated 30,000 Michiganders experiencing homelessness, 5,000+ of PEH in Michigan reside in Detroit1,2. PEH suffered from a quadrupled rate of hospital readmission demonstrating the stark disparity in health outcomes among this population3. Additionally, 6% of the PEH in the state of Michigan engage in substance use1. PWUD have been historically stigmatized and subject to bias both within the healthcare system and otherwise, contributing to adverse health outcomes. Based on current literature, PWUD experiencing stigma and discrimination in …

Assessment Of Breastfeeding Education In Medical Training, Saranya Madan, Abigail Kuplicki

Medical Student Research Symposium

In 2019, the Academy of Breastfeeding Medicine issued a revised set of educational objectives for medical trainees at various stages of education. In this statement, objectives for medical school were broken down into preclinical and clinical training objectives. In this project, our goal is to assess the degree to which medical training at Wayne State University School of Medicine is addressing these aims.

The assessment of breastfeeding education is accomplished by surveying medical students at various stages of training (M1-M4) and eliciting their level of confidence in and understanding of the topics outlined in the objectives by the Academy of …

Racial Disparities In Palliative Care Utilization In The Covid-19 Pandemic, Margaret S. Bove, Benjamin Huber, Myles Hardeman, Daniel Harris, Areeba Jawed, Amber Comer

Medical Student Research Symposium

BACKGROUND

Palliative care is a vital resource for the critically or terminally ill. It has myriad benefits such as improved quality of life, reduced depressive symptoms, and decreased scarce resource utilization. Self-identified Black/African patients, however, are less likely to utilize advanced care directives or engage in hospice/comfort care measures and are more likely to prefer intensive treatment at the end of life. There is no research, however, on how the COVID-19 pandemic may have affected these trends.

METHODS

A retrospective cohort study of patients who experienced in hospital mortality or in hospital hospice due to COVID-19 between March 2020 – …