Digital Commons Network^™

Facile Synthesis Of Fe2o3, Fe2o3@ Cuo And Wo3 Nanoparticles: Characterization, Structure Determination And Evaluation Of Their Biological Activity, Asmaa Taha

Nanotechnology Research Centre

Due to their high specific surface area and its characteristic’s functionalized nanomaterials have great potential in medical applications specialty, as an anticancer. Herein, functional nanoparticles (NPs) based on iron oxide Fe2O3, iron oxide modified with copper oxide Fe2O3@ CuO, and tungsten oxide WO3 were facile synthesized for biomedical applications. The obtained nanomaterials have nanocrystal sizes of 35.5 nm for Fe2O3, 7 nm for Fe2O3@ CuO, and 25.5 nm for WO3. In addition to octahedral and square nanoplates for Fe2O3, and WO3; respectively. Results revealed that Fe2O3, Fe2O3@ CuO, and WO3 NPs showed remarked anticancer effects versus a safe effect on …

“Educational Facials”: A Healing Tool For The Beautiful Struggle, Kari Kokka, Michelle Cody

Teaching and Learning Faculty Research

Critical educators of Color often work to support their students to work toward justice. However, because we live and work in a society imbued with white supremacy, cisheteropatriarchy, and additional systems of oppression, students and colleagues may resist efforts toward equity and racial justice, especially in mathematics education with women of Color instructors. In this paper, two mathematics educators, a Japanese American woman and a Black woman, elaborate a theory of educational facials, first coined by the second author in 2015. The theory of educational facials is an analytic tool for healing from and navigating harmful school climates. The authors …

Unraveling Trends In Schistosomiasis: Deep Learning Insights Into National Control Programs In China, Qing Su, Cici Xi Chen Bauer, Robert Bergquist, Zhiguo Cao, Fenghua Gao, Yi Hu, Zhijie Zhang

Faculty, Staff and Student Publications

OBJECTIVES: to achieve the ambitious goal of eliminating schistosome infections, the Chinese government has implemented diverse control strategies. This study explored the progress of the 2 most recent national schistosomiasis control programs in an endemic area along the Yangtze River in China.

METHODS: We obtained village-level parasitological data from cross-sectional surveys combined with environmental data in Anhui Province, China from 1997 to 2015. A convolutional neural network (CNN) based on a hierarchical integro-difference equation (IDE) framework (i.e., CNN-IDE) was used to model spatio-temporal variations in schistosomiasis. Two traditional models were also constructed for comparison with 2 evaluation indicators: the mean-squared …

Safety And Efficacy Of Dynamic Catheter-Directed Cerebral Digital Subtraction Angiography For Diagnosis Of Bowhunter Syndrome Spectrum Disorders: A Systematic Review Of The Literature, Joo Won Choi, Yang Qiao, Tej I Mehta, Jessica N Wilson, Trevor H Torigoe, Samuel Tsappidi, Y Jonathan Zhang, Stacy C Brown, Ferdinand K Hui, Todd Abruzzo

Faculty, Staff and Student Publications

Introduction: Dynamic catheter-directed cerebral digital subtraction angiography (dcDSA) is the gold standard for diagnosing dynamic vascular occlusion syndromes such as bowhunter syndrome (BHS). Nonetheless, concerns about its safety exist and no standardized protocols have been published to date.

Methods: We describe our methodology and insights regarding the use of dcDSA in patients with BHS. We also perform a systematic literature review to identify cases of typical and atypical presentations of BHS wherein dcDSA was utilized and report on any procedural complications related to dcDSA.

Results: Our study included 104 cases wherein dcDSA was used for the diagnosis of BHS. There …

Parental Satisfaction With Provider Communication And Interventions For Their Autistic, David Escorcia

Walden Dissertations and Doctoral Studies

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition in childhood impacting children globally and involving entire families. It has far-reaching effects on the U.S. healthcare system, communities, and school systems. Recent reports from the CDC reveal that one in 44 children is diagnosed with ASD, emphasizing the need for professional interventions to support the development and well-being of autistic children. However, the existing literature is sparse when it comes to understanding how therapies provided by licensed practitioners are perceived as successful from the standpoint of parents. To address this gap, I undertook secondary data analysis of the National Survey …

Analysis Of Sri Lanka’S Ethnic Inequality Through The Lens Of Polarities Of Democracy, Samanga Amarasinghe

Walden Dissertations and Doctoral Studies

Sri Lanka, despite gaining independence in 1948, has been plagued by ethnic separatism, negatively impacting 29.9% of its ethnic minorities and causing violence and civil unrest throughout the nation. This has hindered the nation’s sustained growth and development. This study addresses Sri Lanka’s ethnic separatism by examining three stages of its history through the lens of the polarities of democracy model. The research question for the study is “How has the balance of polarities of democracy contributed or detracted from Sri Lanka’s pre-colonial, colonial, and post-colonial governance in terms of sustaining ethnic harmony?” The study took the form of a …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Type B Borrow Material Submittal #2 (Dated February 14, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Cytoplasmic Genome Contributions To Domestication And Improvement Of Modern Maize, Shuai Cao, Huanhuan Zhang, Yang Liu, Yi Sun, Z Jeffrey Chen

Faculty, Staff and Student Publications

Background: Studies on maize evolution and domestication are largely limited to the nuclear genomes, and the contribution of cytoplasmic genomes to selection and domestication of modern maize remains elusive. Maize cytoplasmic genomes have been classified into fertile (NA and NB) and cytoplasmic-nuclear male-sterility (CMS-S, CMS-C, and CMS-T) groups, but their contributions to modern maize breeding have not been systematically investigated.

Results: Here we report co-selection and convergent evolution between nuclear and cytoplasmic genomes by analyzing whole genome sequencing data of 630 maize accessions modern maize and its relatives, including 24 fully assembled mitochondrial and chloroplast genomes. We show that the …

Detection Of Acute Brain Injury In Intensive Care Unit Patients On Ecmo Support Using Ultra-Low-Field Portable Mri: A Retrospective Analysis Compared To Head Ct, Sung-Min Cho, Shivalika Khanduja, Jiah Kim, Jin Kook Kang, Jessica Briscoe, Lori R Arlinghaus, Kha Dinh, Bo Soo Kim, Haris I Sair, Audrey-Carelle N Wandji, Elena Moreno, Glenda Torres, Jose Gavito-Higuera, Huimahn A Choi, John Pitts, Aaron M Gusdon, Glenn J Whitman

Faculty, Staff and Student Publications

Early detection of acute brain injury (ABI) is critical to intensive care unit (ICU) patient management and intervention to decrease major complications. Head CT (HCT) is the standard of care for the assessment of ABI in ICU patients; however, it has limited sensitivity compared to MRI. We retrospectively compared the ability of ultra-low-field portable MR (ULF-pMR) and head HCT, acquired within 24 h of each other, to detect ABI in ICU patients supported on extracorporeal membrane oxygenation (ECMO). A total of 17 adult patients (median age 55 years; 47% male) were included in the analysis. Of the 17 patients assessed, …

The Future Of Transnational Surrogacy: Where Do Italy And The Uk Stand Now?, Elleme Ko

Cardozo International & Comparative Law Review (CICLR) Blog

The images of thousands of abandoned babies around the world gave the transnational commercial surrogacy market a global spotlight in 2020 when COVID-19 travel bans hit. As borders closed, intended parents or “fertility tourists” were unable to claim newborns born to surrogate mothers in Russia, Ukraine, the United States, and elsewhere. Babies were left for months in hospitals, orphanages, or in the hands of surrogacy agencies. “‘The image’—of the [commercial surrogacy] industry— ‘was really bad.’” Much attention has been paid to the effects of abortion regulation and access to contraception on women’s reproductive freedom. However, the politics of pregnancy through …

Pembrolizumab Versus Placebo As Adjuvant Therapy In Resected Stage Iib Or Iic Melanoma: Outcomes In Histopathologic Subgroups From The Randomized, Double-Blind, Phase 3 Keynote-716 Trial, Dirk Schadendorf, Jason J. Luke, Paolo A. Ascierto, Georgina V. Long, Piotr Rutkowski, Adnan Khattak, Michele Del Vecchio, Luis De La Cruz-Merino, Jacek Mackiewicz, Vanna C. Sileni, John M. Kirkwood, Caroline Robert, Jean-Jacques Grob, Reinhard Dummer, Matteo S. Carlino, Yujie Zhao, Mizuho Kalabis, Clemens Krepler, Alexander Eggermont, Richard A. Scolyer

Research outputs 2022 to 2026

Background Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) versus placebo in the phase 3 KEYNOTE-716 study of resected stage IIB or IIC melanoma. At the prespecified third interim analysis (data cut-off, January 4, 2022), the HR for RFS in the overall population was 0.64 (95% CI, 0.50 to 0.84) and the HR for DMFS was 0.64 (95% CI, 0.47 to 0.88). We present a post hoc analysis of efficacy by subtypes defined by histopathologic characteristics.

Methods Patients aged ≥ 12 years with newly diagnosed, resected stage IIB or IIC melanoma were randomly assigned (1:1) to …

Retrospective Evaluation Of Penguin Cold Caps For Chemotherapy-Induced Alopecia., Dale Weaver, Michelle L Pershing, Bethany Golden, Laura Hammel, Pauline Kefalas Russ, Mark Cripe

Oncology Articles

BACKGROUND: Scalp cooling is an increasingly recognized non-pharmacologic approach to minimize chemotherapy-induced alopecia (CIA). Several commercially available machine-based and manual scalp cooling systems are available; however, literature reports of effectiveness are highly variable. The purpose of this study was to determine real-world tolerability and subjective effectiveness of a manual cold capping system in minimizing CIA across a variety of patient race and hair types. This study was a single-institution review of outcomes from manual cold capping.

METHODS: We identified retrospective cohort of adult patients who presented to discuss cold capping between January 14, 2019, and March 31, 2022. Data collected …

Dysregulated Creb3 Cleavage At The Nuclear Membrane Induces Karyoptosis-Mediated Cell Death, Ga-Eun Lee, Geul Bang, Jiin Byun, Cheol-Jung Lee, Weidong Chen, Dohyun Jeung, Hyun-Jung An, Han Chang Kang, Dae Joon Kim, Megan Keniry

School of Medicine Publications

Cancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to other types of cell death. Elucidating additional mechanisms that govern cancer cell death is crucial for developing new therapies. Our research identified cyclic AMP-responsive element-binding protein 3 (CREB3) as a crucial regulator and initiator of a unique cell death mechanism known as karyoptosis. This process is characterized by nuclear shrinkage, deformation, and the loss of nuclear components following nuclear membrane rupture. We found that the N-terminal domain (aa 1-230) of full-length CREB3 (CREB3-FL), which is anchored to the nuclear inner membrane (INM), interacts with lamins …

Bioaccumulation Of Сr, Zn, Pb And Cu In Ambrosia Artemisiifolia L. And Erigeron Canadensis L., Volodymyr Laptiev, Samuel Obeng Apori, Michelle Giltrap, Furong Tian, Nataliia Ryzhenko

Articles

The city of Dnipro, a prominent industrial hub in Ukraine, is recognized for its particularly its significant industrial development. This study focused on two prevalent plant species, Ambrosia artemisiifolia L. and Erigeron canadensis L., within the vicinity. Sampling was conducted at points located 12.02 km away from the emission sources associated with battery production and recycling plants in Dnipro. Analysis of heavy metal concentrations such as, Cr, Cu, Pb, and Zn was conducted using atomic emission spectrometry from the soil and plants tissues of Ambrosia artemisiifolia L. and Erigeron canadensis L. The translocation coefficient (TF) was calculated for both plant …

Medical Monitoring Working Group Meeting Minutes, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Health Status In An Urban-Dwelling, Subtropical Frog Species (Lithobates Sphenocephalus) And Its Relation To Ranavirus And Hemoparasites, Gabrielle M. Wickersham

USF Tampa Graduate Theses and Dissertations

Urbanization poses significant challenges to wildlife, including amphibians. The present study uses a multi-parameter approach that incorporates veterinary techniques to investigate the current health status of the adult southern leopard frogs (Lithobates sphenocephalus) in Tampa Bay, Florida, amidst urban stressors including nutrient loading, fragmented habitats, and light and noise pollution. Novel values for fluctuating asymmetry (e.g., variation between left and right bilateral traits; FA), body condition (CF), stress (e.g., neutrophil:lymphocyte (N:L) ratio), and inflammation (e.g., neutrophil morphologic abnormalities, parasite load) are reported. I also investigate the relationship of overall health with ranavirus presence and hemoparasite infections. Ranavirus was absent in …

The Identification Of Small Molecule Inhibitors With Anthelmintic Activities That Target Conserved Proteins Among Ruminant Gastrointestinal Nematodes, Hyeim Jung, Dante Zarlenga, John C Martin, Peter Geldhof, Kymberlie Hallsworth-Pepin, Makedonka Mitreva

2020-Current year OA Pubs

Gastrointestinal nematode (GIN) infections are a major concern for the ruminant industry worldwide and result in significant production losses. Naturally occurring polyparasitism and increasing drug resistance that potentiate disease outcomes are observed among the most prevalent GINs of veterinary importance. Within the five major taxonomic clades, clade Va represents a group of GINs that predominantly affect the abomasum or small intestine of ruminants. However, the development of effective broad-spectrum anthelmintics against ruminant clade Va GINs has been challenged by a lack of comprehensive druggable genome resources. Here, we first assembled draft genomes for three clade Va species (

Quality Improvement In Public-Private Partnerships In Low- And Middle-Income Countries: A Systematic Review, Cassandra Iroz, Rohit Ramaswamy, Zulfiqar Bhutta, Paul Barach

College of Population Health Faculty Papers

BACKGROUND: Public-private partnerships (PPP) are often how health improvement programs are implemented in low-and-middle-income countries (LMICs). We therefore aimed to systematically review the literature about the aim and impacts of quality improvement (QI) approaches in PPP in LMICs.

METHODS: We searched SCOPUS and grey literature for studies published before March 2022. One reviewer screened abstracts and full-text studies for inclusion. The study characteristics, setting, design, outcomes, and lessons learned were abstracted using a standard tool and reviewed in detail by a second author.

RESULTS: We identified 9,457 citations, of which 144 met the inclusion criteria and underwent full-text abstraction. We …

Final 2024 Butte Priority Soils Operable Unit Type B Borrow Material Submittal #2, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Interrelationships Among Local Values Of Wet Bulb Globe Temperature, Heat Index, And Adjusted Temperature, Andrea Giraldo

USF Tampa Graduate Theses and Dissertations

Occupational heat stress significantly affects outdoor workers who face challenges due to increased heat exposure. Because of the prevalence of heat illness, it is important to measure heat stress for outdoor workers. Monitoring occupational heat stress most often relies on the Wet Bulb Globe Temperature (WBGT) measure. Heat Index (HI) is a widely used measure to account for air temperature and humidity. Adjusted Temperature (Tadj) considers air temperature, humidity and estimates radiant heat. There is interest in predicting WBGT from HI and HI from WBGT. This study builds on previous USF research by Bernard and Iheanacho and Irvin to evaluate …

“Urban Renewal” Surrounding Florida Solar Plants: A Study On Low-Carbon Gentrification, Megan Amber Grove

USF Tampa Graduate Theses and Dissertations

Renewable energy and sustainable living are growing trends in Florida as the state “develops” rural landscapes and “redevelops” urban ones, resulting in neighborhood changes, including displacement of low-income and minority populations (LIMP). Solar energy has not historically been a root cause of such changes, but in recent years it has increasingly accompanied neighborhood development which prioritizes the interests of the elite and middle class. As such, it has become a contributor to “urban renewal,” which must be addressed to avoid future LIMP displacement. This study used geospatial and data science technologies and techniques to empirically explore and analyze urbanization and …

A Differentially Methylated Region Analysis Between Three Disease States Of Major Depressive Disorder In Primarily African-American Cohorts, Lanie Katelynn Mullins

USF Tampa Graduate Theses and Dissertations

Major depressive disorder (MDD) is a common and debilitating disorder that affects millions of people worldwide. MDD is a multifactorial disease with no established mechanism currently able to explain all facets of the disease or its etiology. Feedback loop mechanisms have been posited to explain the interactions of psychological and physical components of the disease etiology. Epigenetics, specifically DNA-methylation analyses, can shed light on the interaction between the within-person environment resulting from MDD symptomology, the persistence of the disease, and factors influencing remission. Here, a differentially methylated region analysis was conducted using samples derived from whole blood to interrogate the …

Border-Associated Macrophages In The Central Nervous System, Rui Sun, Haowu Jiang

2020-Current year OA Pubs

Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchymal microglia and non-parenchymal border-associated macrophages (BAMs). Among these immune cell populations, microglia have been well-studied for their roles during development as well as in health and disease. BAMs, mostly located in the choroid plexus, meningeal and perivascular spaces, are now gaining increased attention due to advancements in multi-omics technologies and genetic methodologies. Research on BAMs over the past decade has focused on their ontogeny, immunophenotypes, involvement in various CNS diseases, and potential …

Calpain-2 Mediates Sars-Cov-2 Entry Via Regulating Ace2 Levels, Qiru Zeng, Avan Antia, Luis Alberto Casorla-Perez, Maritza Puray-Chavez, Sebla B Kutluay, Matthew A Ciorba, Siyuan Ding

2020-Current year OA Pubs

UNLABELLED: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A number of calpain inhibitors show excellent antiviral activities against SARS-CoV-2 by targeting the viral main protease (M

IMPORTANCE: Many efforts in small-molecule screens have been made to counter SARS-CoV-2 infection by targeting the viral main protease, the major element that processes viral proteins after translation. Here, we discovered that calpain inhibitors further block SARS-CoV-2 infection in a main protease-independent manner. We identified the host cysteine protease calpain-2 as an important positive …

A Phase I Trial Of Pevonedistat In Combination With Ruxolitinib For The Treatment Of Myelofibrosis, Tim Kong, Nicole Gaudin, Karyn Gordon, Maggie J Cox, Amy W Zhou, Stephen T Oh

2020-Current year OA Pubs

Janus kinase 2 (JAK2) inhibitors such as ruxolitinib have become standard-of-care therapy for patients with myeloproliferative neoplasms (MPNs); however, activation of alternate oncogenic pathways including nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) has limited durable response as single-agent therapy. With the rationale of targeting both pathways, we conducted a phase I dose escalation trial of pevonedistat in combination with ruxolitinib for the treatment of patients with myelofibrosis (NCT03386214). The primary objective was to assess the safety and tolerability of combination therapy with additional objectives of treatment efficacy and alterations of biomarkers. There were no dose-limiting toxicities observed with most …

Short Cell Cycle Duration Is A Phenotype Of Human Epidermal Stem Cells, Tong Xiao, Ugomma C Eze, Alex Charruyer-Reinwald, Tracy Weisenberger, Ayman Khalifa, Brook Abegaze, Gabrielle K Schwab, Rasha H Elsabagh, T Richard Parenteau, Karl Kochanowski, Merisa Piper, Yumin Xia, Jeffrey B Cheng, Raymond J Cho, Ruby Ghadially

Staff and Researcher Publications

Background: A traditional view is that stem cells (SCs) divide slowly. Meanwhile, both embryonic and pluripotent SCs display a shorter cell cycle duration (CCD) in comparison to more committed progenitors (CPs).

Methods: We examined the in vitro proliferation and cycling behavior of somatic adult human cells using live cell imaging of passage zero keratinocytes and single-cell RNA sequencing.

Results: We found two populations of keratinocytes: those with short CCD and protracted near exponential growth, and those with long CCD and terminal differentiation. Applying the ergodic principle, the comparative numbers of cycling cells in S phase in an enriched population of …

Exploring The Effectiveness Of Virtual And In-Person Instruction In Culinary Medicine: A Survey-Based Study., Orli Glickman, Joanne Kakaty-Monzo, Michael B. Roberts, Farzaneh Daghigh

PCOM Scholarly Works

BACKGROUND: Culinary medicine, which has recently increased in popularity in medical education, incorporates food and nutritional interventions with principles of disease prevention and treatment. The ultimate goal is to improve overall health outcomes. The growing prevalence of diet-related chronic diseases indicates the need for physicians to have a deeper understanding of the interplay between nutrition and disease. Incorporating culinary medicine into medical education can equip medical students with the necessary skills and knowledge to promote better patient outcomes. The purpose of this study was to evaluate students' perceptions of their foundational knowledge of a culinary medicine course after completion of …

Apparent Diffusion Coefficient Values Predict Response To Brachytherapy In Bulky Cervical Cancer, Elizabeth E Dong, Junqian Xu, Joo-Won Kim, Jason Bryan, Jewel Appleton, Daniel A Hamstra, Michelle S Ludwig, Alexander N Hanania

Faculty, Staff and Students Publications

BACKGROUND: Diffusion-weighted magnetic resonance imaging (DWI) provides a measurement of tumor cellularity. We evaluated the potential of apparent diffusion coefficient (ADC) values obtained from post-external beam radiation therapy (EBRT) DWI and prior to brachytherapy (BT) to predict for complete metabolic response (CMR) in bulky cervical cancer.

METHODS: Clinical and DWI (b value = 500 s/mm2) data were obtained from patients undergoing interstitial BT with high-risk clinical target volumes (HR-CTVs) > 30 cc. Volumes were contoured on co-registered T2 weighted images and 90th percentile ADC values were calculated. Patients were stratified by CMR (defined by PET-CT at three months post-BT). Relation of …

Frontier Analysis Of The Container Ports In Taiwan During The Covid Pandemic, Sen-Kuei Kuo, Guo-Ya Gan, Hsuan-Shih Lee

Journal of Marine Science and Technology–Taiwan

The COVID-19 outbreak has severely impacted global trade and cultural exchanges. Among its impacts are those on the international container shipping market, which is directly related to the national economy and trade and has naturally been affected. This market was in the doldrums during the pandemic. In general, COVID-19 has severely constrained shipping industry development in various countries. To this end, this study analyzes the frontier changes in the efficiency development of Taiwan's international container ports by collecting realistic operational data of the major container ports during the pandemic and combining them with measurements of the Malmquist Productivity Index and …

The Experience Of Knowledge Workers In Remote Environments During The Covid-19 Pandemic, Dale F. Knapp

Doctor of Education Program Dissertations

When regional quarantine restrictions were rapidly implemented in March 2020 due to the COVID-19 pandemic, knowledge workers were forced to vacate their traditional shared office spaces and transition to remote work environments. This unprecedented mass exodus from traditional in-person physical workplaces was facilitated by existing and new software and technology that allowed workers to remain connected and working. This phenomenological study explored the lived experiences and perceptions of knowledge workers who experienced this transition to a full-time remote work environment. The study also examined how knowledge workers perceived work performance relative to their experience during the COVID-19 pandemic. Data were …