Digital Commons Network^™

Recent Progress On Gene-Deleted Liveattenuated African Swine Fever Virus Vaccines, Hiep L.X. Vu, David Scott Mcvey

Department of Animal Science: Faculty Publications

African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease has spread to many swine-producing countries, leading to significant economic losses and adversely impacting global food security. Extensive efforts have been directed toward developing effective ASF vaccines. Among the vaccinology approaches tested to date, liveattenuated virus (LAV) vaccines produced by rational deleting virulence genes from virulent African Swine Fever Virus (ASFV) strains have demonstrated promising safety and efficacy in experimental and field conditions. Many gene-deleted LAV vaccine candidates have been generated in recent years. The virulence genes targeted for deletion from …

Recent Progress On Gene-Deleted Liveattenuated African Swine Fever Virus Vaccines, Hiep Vu, David Scott Mcvey

Department of Animal Science: Faculty Publications

African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease has spread to many swine-producing countries, leading to significant economic losses and adversely impacting global food security. Extensive efforts have been directed toward developing effective ASF vaccines. Among the vaccinology approaches tested to date, liveattenuated virus (LAV) vaccines produced by rational deleting virulence genes from virulent African Swine Fever Virus (ASFV) strains have demonstrated promising safety and efficacy in experimental and field conditions. Many gene-deleted LAV vaccine candidates have been generated in recent years. The virulence genes targeted for deletion from …

Spectrum, Volume 52, Issue 6, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Controversial IVF Law in Alabama Raises Questions on Reproductive Freedom - Inside SHU’s Faculty Peer Coaching Program - Faculty Peer Coaching Program - A Look Into The Music Education Program - Multicultural Center Wisdom Wednesdays - The Comfort of Stuffed Animals for College Students - Professor Produces New Film Featuring Students

March 13, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Whole-Of-School Physical Activity Implementation In The Context Of The Dubai Fitness Challenge, Chris Mcmahon, Collin A. Webster, Robert Weaver, Christophe El Haber, Gönül Tekkurşun Demir, Zainab Mohamed Ismail, Syeda Zoha Fatima Naqvi, Mehnaz Ghani, Şevval Kepenek, Manel Kherraf, Thrisha Krishnakumar, Pranati Prakash, Yeowon Seo

Faculty Publications

Introduction

Physical activity (PA) promotion among school-aged youth is a global health priority. Recommendations for such promotion include implementing whole-of-school approaches that maximize resources across the school environment. This study examined schools’ participation in an annual, government-led, and emirate-wide initiative in Dubai, called the Dubai Fitness Challenge, in which the goal is to accrue 30 minutes of PA every day for 30 days (as such, the initiative is colloquially referred to as “Dubai 30x30”).

Methods

A mixed-methods design was employed for this study. Three schools were recruited using convenience sampling. Participants were 18 physical education teachers, 20 classroom teachers, 2 …

Leroy Williams V. School District Of Philadelphia

2024 Decisions

USDC for the Eastern District of Pennsylvania

Guinness Is The "Pumpkin Spice Latte" Of St. Patrick's Day, Jin-A Choi, Bond Benton, Yi Luo

College of Communication and Media Scholarship and Creative Works

This study by a team of faculty from the Joetta Di Bella and Fred C. Sautter III Center for Strategic Communication in the School of Communication and Media at Montclair State University shows that Guinness was the most-discussed brand on social media leading up to St. Patrick’s Day, and not just in the traditional ways people share how they drink the popular beer brand. The volume of social media conversations related to Guinness beer and St. Patrick’s Day saw a 25% increase. Most social chats exhibited a happy mood as evidenced by a 62% joyful sentiment.

While the Shamrock Shake …

Commonwealth Times 2024-03-13

Commonwealth Times, 1969-

No abstract provided.

Girls Deliver Workshop On The Sidelines Of Csw68, Population Council

Girl Innovation, Research, and Learning (GIRL) Center

No abstract provided.

Microcurrent-Mediated Modulation Of Myofibroblasts For Cardiac Repair And Regeneration, Dipthi Bachamanda Somesh, Karsten Jürchott, Thomas Giesel, Thomas Töllner, Alexander Prehn, Jan-Peter Richters, Dragana Kosevic, J. Eduardo Rame, Peter Göttel, Johannes Müller

Division of Cardiology Faculty Papers

Cardiovascular diseases are a significant cause of illness and death worldwide, often resulting in myofibroblast differentiation, pathological remodeling, and fibrosis, characterized by excessive extracellular matrix protein deposition. Treatment options for cardiac fibrosis that can effectively target myofibroblast activation and ECM deposition are limited, necessitating an unmet need for new therapeutic approaches. In recent years, microcurrent therapy has demonstrated promising therapeutic effects, showcasing its translational potential in cardiac care. This study therefore sought to investigate the effects of microcurrent therapy on cardiac myofibroblasts, aiming to unravel its potential as a treatment for cardiac fibrosis and heart failure. The experimental design involved …

Viral Epitope Scanning Reveals Correlation Between Seasonal Hcovs And Sars-Cov-2 Antibody Responses Among Cancer And Non-Cancer Patients, Salum J. Lidenge, Dicle Yalcin, Sydney J. Bennett, Owen Ngalamika, Brenda B. Kweyamba, Chacha J. Mwita, For Yue Tso, Julius Mwaiselage, John T. West, Charles Wood

School of Medicine Faculty Publications

Seasonal coronaviruses (HCoVs) are known to contribute to cross-reactive antibody (Ab) responses against SARS-CoV-2. While these responses are predictable due to the high homology between SARS-CoV-2 and other CoVs, the impact of these responses on susceptibility to SARS-CoV-2 infection in cancer patients is unclear. To investigate the influence of prior HCoV infection on anti-SARS-CoV-2 Ab responses among COVID-19 asymptomatic individuals with cancer and controls without cancers, we utilized the VirScan technology in which phage immunoprecipitation and sequencing (PhIP-seq) of longitudinal plasma samples was performed to investigate high-resolution (i.e., epitope level) humoral CoV responses. Despite testing positive for anti-SARS-CoV-2 Ab in …

Miniature Optical Fiber Fabry-Perot Interferometer Based On A Single-Crystal Metal-Organic Framework For The Detection And Quantification Of Benzene And Ethanol At Low Concentrations In Nitrogen Gas, Farhan Mumtaz, Bohong Zhang, Narasimman Subramaniyam, Mohammad Roman, Peter Holtmann, Abhishek Prakash Hungund, Ryan O'Malley, Thomas M. Spudich, Michael Davis, Rex E. Gerald, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

This study reports for the first time, to the best of our knowledge, a real-time detection of ultralow-concentration chemical gases using fiber-optic technology, combining a miniaturized Fabry-Perot interferometer (FPI) with metal-organic frameworks (MOFs). The sensor consists of a short and thick-walled silica capillary segment spliced to a lead-in single-mode fiber (SMF), housing a tiny single crystal of HKUST-1 MOF, imparting chemo selectivity features. Ethanol and benzene gases were tested, resulting in a shift in the FPI interference signal. The sensor demonstrated high sensitivity, detecting ethanol gas concentrations (EGCs) with a sensitivity of 0.428 nm/ppm between 24.9 and 40.11 ppm and …

Modified Folfox6 Plus Bevacizumab With And Without Nivolumab For First-Line Treatment Of Metastatic Colorectal Cancer: Phase 2 Results From The Checkmate 9x8 Randomized Clinical Trial, Antonio Ucar

All Publications

Background: Standard first-line therapies for metastatic colorectal cancer (mCRC) include fluoropyrimidine-containing regimens with oxaliplatin and/or irinotecan and a biologic agent. Immunotherapy may enhance antitumor activity in combination with standard therapies in patients with mCRC. Here, we present phase 2 results of nivolumab plus standard-of-care therapy (SOC; 5-fluorouracil/leucovorin/oxaliplatin/bevacizumab) versus SOC in the first-line treatment of patients with mCRC (CheckMate 9X8).

Methods: CheckMate 9X8 was a multicenter, open-label, randomized, phase 2/3 trial. Eligible patients were at least 18 years of age with unresectable mCRC and no prior chemotherapy for metastatic disease. Patients were randomized 2:1 to receive nivolumab 240 mg plus SOC …

March 13, 2024 (Vol. 108, No. 23), Daily Eastern News

Daily Eastern News: 2023-2024

No abstract provided.

Β-Sheets Mediate The Conformational Change And Allosteric Signal Transmission Between The Aslov2 Termini, Sian Xiao, Mayar Terek Ibrahim, Gennady M. Verkhivker, Brian D. Zoltowski, Peng Tao

Mathematics, Physics, and Computer Science Faculty Articles and Research

Avena sativa phototropin 1 light-oxygen-voltage 2 domain (AsLOV2) is a model protein of Per-Arnt-Sim (PAS) superfamily, characterized by conformational changes in response to external environmental stimuli. This conformational change begins with the unfolding of the N-terminal A'α helix in the dark state followed by the unfolding of the C-terminal Jα helix. The light state is characterized by the unfolded termini and the subsequent modifications in hydrogen bond patterns. In this photoreceptor, β-sheets are identified as crucial components for mediating allosteric signal transmission between the two termini. Through combined experimental and computational investigations, the Hβ …

Increasing Multi-Hazard Climate Risk And Financial And Health Impacts On Northern Homeowners, Tobias Schwoerer, Jennifer I. Schmidt, Matthew Berman, Peter Bieniek, Louise M. Farquharson, Dmitry Nicolsky, James E. Powell, Rachel Roberts, Rick Thoman, Robert Ziel

Faculty, Staff, and Students

Currently, more than half of the world’s human population lives in urban areas, which are increasingly affected by climate hazards. Little is known about how multi-hazard environments affect people, especially those living in urban areas in northern latitudes. This study surveyed homeowners in Anchorage and Fairbanks, USA, Alaska’s largest urban centers, to measure individual risk perceptions, mitigation response, and damages related to wildfire, surface ice hazards, and permafrost thaw. Up to one third of residents reported being affected by all three hazards, with surface ice hazards being the most widely distributed, related to an estimated $25 million in annual damages. …

A Comparative Review Of Typical And Atypical Optic Neuritis: Advancements In Treatments, Diagnostics, And Prognosis, Noah J. Spillers, Patrick M. Luther, Norris C. Talbot, Evan J. Kidder, Connor A. Doyle, Salim C. Lutfallah, Alyssa G. Derouen, Sridhar Tirumala, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi

School of Medicine Faculty Publications

Optic neuritis (ON) is a debilitating condition that through various mechanisms, including inflammation or demyelination of the optic nerve, can result in partial or total permanent vision loss if left untreated. Accurate diagnosis and promptly initiated treatment are imperative related to the potential of permanent loss of vision if left untreated, which can lead to a significant reduction in the quality of life in affected patients. ON is subtyped as "typical" or "atypical" based on underlying causative etiology. The etiology of ON can be differentiated when appropriate diagnostic testing is performed. Using history taking, neuroimaging, and visual testing to localize …

Geography, Climate, And Habitat Shape The Microbiome Of The Endangered Rock Gnome Lichen (Cetradonia Linearis), Julianna Paulsen, Jessica L. Allen, Nathan Morris, Jenna Dorey, Jenifer B. Walke, S. Elizabeth Alter

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Bacterial symbionts are essential components of healthy biological systems. They are increasingly recognized as important factors in the study and management of threatened species and ecosystems. Despite management shifts at the ecosystem level, microbial communities are often neglected in discussions of holobiont conservation in favor of the primary members of a symbiosis. In this study, we addressed the bacterial community knowledge gap for one of two federally endangered lichen species in the United States, Cetradonia linearis (Cladoniaceae). We collected 28 samples of the endangered rock gnome lichen (Cetradonia linearis) from 13 sites and characterized bacterial communities in thalli using 16S …

Effectiveness Of The Introduction To Critical Care In Emergency Medicine Curriculum's Implementation Among Trainees Interested In Intensive Care, Matthew M.T. Carvey

Researchers, Instructors, & Staff Scholarship

Background: Emergency physicians and trainees provide the initial care for critically ill patients. In times of emergency department boarding, this care may extend beyond the first few hours. To meet the needs of this population, a standardized novel critical care curriculum targeting third- and fourth-year medical students was developed. Objectives: We hypothesized that the institution of such a curriculum is feasible and will provide an increased understanding of the underlying critical care principles within this learner population. Methods: We developed a 2-month-long critical care curriculum (February–April) and carried out the course twice from 2022–2023. Our pilot study deployed this curriculum …

A Novel Staging System To Consolidate Silent Sinus Syndrome And Chronic Maxillary Atelectasis: A Systematic Review And Case Series, Dev Amin, Shreya Mandloi, Kathryn Nunes, Neha Garg, Chase Kahn, Alexander Duffy, Elina Toskala, Mindy Rabinowitz, Marc Rosen, Gurston Nyquist

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Key points:

• Silent sinus syndrome (SSS) and chronic maxillary atelectasis (CMA) represent an overlapping clinical entity, both likely lying on the spectrum of one disease process.
• There is widespread inconsistency of diagnosis in the literature of reported cases of SSS and CMA.
• We propose a novel, comprehensive staging system to simplify diagnosis and inform management.

The Bg News March 13, 2024, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. March 13, 2024. Volume 103-Issue 19.

The Parthenon, March 13, 2024, Evan Green, Matthew Schaffer, Sarah Davis, Joseph Dicristofaro, Victoria Ware, Abigail Cutlip, Rafael Alfonso, Scott Price, Baylee Parsons, Emma Gallus, Luke Jeffrey

The Parthenon

No abstract provided.

An Exposome Atlas Of Serum Reveals The Risk Of Chronic Diseases In The Chinese Population, Lei You, Jing Kou, Mengdie Wang, Guoqin Ji, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu, Surong Mei, Guowang Xu

Faculty, Staff and Student Publications

Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, …

Genomic Evolution Shapes Prostate Cancer Disease Type, Dan J Woodcock, Atef Sahli, Ruxandra Teslo, Vinayak Bhandari, Andreas J Gruber, Aleksandra Ziubroniewicz, Gunes Gundem, Yaobo Xu, Adam Butler, Ezequiel Anokian, Bernard J Pope, Chol-Hee Jung, Maxime Tarabichi, Stefan C Dentro, J Henry R Farmery, Cruk Icgc Prostate Group, Peter Van Loo, Anne Y Warren, Vincent Gnanapragasam, Freddie C Hamdy, G Steven Bova, Christopher S Foster, David E Neal, Yong-Jie Lu, Zsofia Kote-Jarai, Michael Fraser, Robert G Bristow, Paul C Boutros, Anthony J Costello, Niall M Corcoran, Christopher M Hovens, Charlie E Massie, Andy G Lynch, Daniel S Brewer, Rosalind A Eeles, Colin S Cooper, David C Wedge

Faculty, Staff and Student Publications

The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a different aspect of tumor evolution. Integrating the results revealed the existence of two distinct types of prostate cancer that arise from divergent evolutionary trajectories, designated as the Canonical and Alternative evolutionary disease types. We therefore propose the evotype model for prostate cancer evolution wherein Alternative-evotype …

Resolving The Nanoscale Structure Of Β-Sheet Peptide Self-Assemblies Using Single-Molecule Orientation–Localization Microscopy, Weiyan Zhou, Conor L. O'Neill, Tianben Ding, Oumeng Zhang, Jai S. Rudra, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Synthetic peptides that self-assemble into cross-β fibrils are versatile building blocks for engineered biomaterials due to their modularity and biocompatibility, but their structural and morphological similarities to amyloid species have been a long-standing concern for their translation. Further, their polymorphs are difficult to characterize using spectroscopic and imaging techniques that rely on ensemble averaging to achieve high resolution. Here, we utilize Nile red (NR), an amyloidophilic fluorogenic probe, and single-molecule orientation-localization microscopy (SMOLM) to characterize fibrils formed by the designed amphipathic enantiomers KFE8^L and KFE8^D and the pathological amyloid-beta peptide Aβ42. Importantly, NR SMOLM reveals the helical (bilayer) …

Ecological Validity Of Simulated Ethical Situations In Therapy Part 2, Melissa Chavez

Undergraduate Honors Theses

Psychotherapy recipients seek optimal treatment, emphasizing the importance of therapists undergoing evidence-based training for effective outcomes. Deliberate practice (DP) is a proven method for systematic improvement. While still evolving, DP shows promise in various domains, including psychotherapy, with effective implementation requiring goal setting, feedback, and persistence.

This study introduces videos simulating ethical dilemmas in therapy. To assess the ecological validity of these videos, a survey examines participants' perceptions of realism, difficulty, and anticipated anxiety across 11 ethical scenarios. Participants include undergraduate and graduate students, as well as licensed professionals. This research aims to provide empirical evidence supporting the validity of …

Ways To Improve Uptake Of Tier 2 Weight Management Programmes In Bame Communities In Medway: A Qualitative Study, Jennifer A. Teke, Johnson Mbabazi, Emma Giles, Scott Elliot, Louisa Ells, Lawrence Achilles Nnyanzi

International Journal of Physical Activity and Health

Overweight and obesity is usually determined by Body Mass Index (BMI). Twelve BAME adults participated in the interviews: six were female, ten were first-generation migrants, three were retirees, none lived with a disability, and all were concerned about their excess weight. There were four themes from the data and eight subthemes obtained. To improve the uptake of the weight management service provided in Medway, the participants recommended the use of strategies such as indigenous food labelling, BAME-led clinics, the use of translated leaflets, the recruitment of local weight management champions, better coordination of services, appropriate communication strategies, and further research. …

Pharmacokinetics Of Propofol In Severely Obese Surgical Patients, Martin Rygh Braathen, Ann E. Rigby-Jones, Johan Ræder, Olav Spigset, Tom Heier

Peninsula Medical School

Background: Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and including, a high number of very obese patients. Methods: Adult patients scheduled for laparoscopic cholecystectomy or bariatric surgery were studied. Anaesthesia was induced with propofol 2 mg/kg adjusted body weight over 2 min followed by 6 mg/kg/h adjusted body weight over 30 min. For the remainder of the operation anaesthesia was maintained with sevoflurane. Remifentanil was dosed according to clinical need. Eight arterial samples …

The Impact Of Robotic Assistance For Lumbar Fusion Surgery On 90-Day Surgical Outcomes And 1-Year Revisions, Jeremy Heard, Yunsoo Lee, Nicholas D D'Antonio, Rajkishen Narayanan, Mark Lambrechts, John Bodnar, Caroline Purtill, Joshua Pezzulo, Dominic Farronato, Pat Fitzgerald, Jose Canseco, Ian Kaye, Alan Hilibrand, Alex Vaccaro, Christopher Kepler, Gregory Schroeder

Department of Orthopaedic Surgery Faculty Papers

Objectives: To evaluate the (1) 90-day surgical outcomes and (2) 1-year revision rate of robotic versus nonrobotic lumbar fusion surgery. Methods: Patients >18 years of age who underwent primary lumbar fusion surgery at our institution were identified and propensity-matched in a 1:1 fashion based on robotic assistance during surgery. Patient demographics, surgical characteristics, and surgical outcomes, including 90-day surgical complications and 1-year revisions, were collected. Multivariable regression analysis was performed. Significance was set to P < 0.05. Results: Four hundred and fifteen patients were identified as having robotic lumbar fusion and were matched to a control group. Bivariant analysis revealed no significant difference in total 90-day surgical complications (P = 0.193) or 1-year revisions (P = 0.178). The operative duration was longer in robotic surgery (287 + 123 vs. 205 + 88.3, P ≤ 0.001). Multivariable analysis revealed that robotic fusion was not a significant predictor of 90-day surgical complications (odds ratio [OR] = 0.76 [0.32-1.67], P = 0.499) or 1-year revisions (OR = 0.58 [0.28-1.18], P = 0.142). Other variables identified as the positive predictors of 1-year revisions included levels fused (OR = 1.26 [1.08-1.48], P = 0.004) and current smokers (OR = 3.51 [1.46-8.15], P = 0.004). Conclusion: Our study suggests that robotic-assisted and nonrobotic-assisted lumbar fusions are associated with a similar risk of 90-day surgical complications and 1-year revision rates; however, robotic surgery does increase time under anesthesia.

Inducing Vulnerability To Inha Inhibition Restores Isoniazid Susceptibility In Drug-Resistant Mycobacterium Tuberculosis, Gregory A Harrison, Erin R Wang, Kevin Cho, Yassin Mreyoud, Souvik Sarkar, Fredrik Almqvist, Gary J Patti, Christina L Stallings

2020-Current year OA Pubs

Of the approximately 10 million cases of