Digital Commons Network^™

A Therapeutically Targetable Positive Feedback Loop Between Nc-Hlx-2-7, Hlx, And Myc That Promotes Group 3 Medulloblastoma, Keisuke Katsushima, Kandarp Joshi, Menglang Yuan, Brigette Romero, Mona Batish, Stacie Stapleton, George Jallo, Elayaraja Kolanthai, Sudipta Seal, Olivier Saulnier, Michael D Taylor, Robert J Wechsler-Reya, Charles G Eberhart, Ranjan J Perera

Faculty, Staff and Students Publications

Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma (MB) formation and progression. We have identified an lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) MBs. lnc-HLX-2-7 RNA specifically accumulates in the promoter region of HLX, a sense-overlapping gene of lnc-HLX-2-7, which activates HLX expression by recruiting multiple factors, including enhancer elements. RNA sequencing and chromatin immunoprecipitation reveal that HLX binds to and activates the promoters of several oncogenes, including TBX2, LIN9, HOXM1, and MYC. Intravenous treatment with cerium-oxide-nanoparticle-coated antisense oligonucleotides targeting lnc-HLX-2-7 (CNP-lnc-HLX-2-7) inhibits tumor growth by 40%-50% in an intracranial MB xenograft mouse …

Methionyl-Trna Synthetase Synthetic And Proofreading Activities Are Determinants Of Antibiotic Persistence, Whitney N. Wood, Miguel Angel Rubio, Lorenzo Eugenio Leiva, Gregory J. Phillips, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Bacterial antibiotic persistence is a phenomenon where bacteria are exposed to an antibiotic and the majority of the population dies while a small subset enters a low metabolic, persistent, state and are able to survive. Once the antibiotic is removed the persistent population can resuscitate and continue growing. Several different molecular mechanisms and pathways have been implicated in this phenomenon. A common mechanism that may underly bacterial antibiotic persistence is perturbations in protein synthesis. To investigate this mechanism, we characterized four distinct metG mutants for their ability to increase antibiotic persistence. Two metG mutants encode changes near the catalytic site …

Targeting Cxcr4, Vla-4, And Cxcr2 For Hematopoietic Stem Cell Mobilization, Daniel Cancilla, Michael P Rettig, Darja Karpova, Haresh Thakellapalli, Megh Singh, Marvin J Meyers, Peter G Ruminski, Stephanie Christ, Ezhilarasi Chendamarai, Feng Gao, Leah Gehrs, Julie K Ritchey, Michael Prinsen, John F Dipersio

2020-Current year OA Pubs

No abstract provided.

Impact Of Imaging Frequency On Progression-Free Survival In Alliance Trials Enrolling Patients With Follicular Lymphoma, Sarah C Rutherford, Jun Yin, Levi D Pederson, Kristie A Blum, Peter Martin, Sin-Ho Jung, Barbara Grant, Cara Rosenbaum, Bruce D Cheson, Nancy L Bartlett, Sumithra J Mandrekar, John P Leonard

2020-Current year OA Pubs

No abstract provided.

Phase 2 Study Of Add-On Parsaclisib For Patients With Myelofibrosis And Suboptimal Response To Ruxolitinib: Final Results, Abdulraheem Yacoub, Stephen T Oh, Et Al.

2020-Current year OA Pubs

Ruxolitinib reduces spleen volume, improves symptoms, and increases survival in patients with intermediate- or high-risk myelofibrosis. However, suboptimal response may occur, potentially because of signaling via the phosphoinositide 3-kinase (PI3K)/protein kinase B pathway. This phase 2 study evaluated dosing, efficacy, and safety of add-on PI3Kδ inhibitor parsaclisib for patients with primary or secondary myelofibrosis with suboptimal response to ruxolitinib. Eligible patients remained on a stable ruxolitinib dose and received add-on parsaclisib 10 or 20 mg, once daily for 8 weeks, and once weekly thereafter (daily-to-weekly dosing; n = 32); or parsaclisib 5 or 20 mg, once daily for 8 weeks, …

Next Generation Microfluidics: Fulfilling The Promise Of Lab-On-A-Chip Technologies, Umut A Gurkan, Jorge Di Paola, Et Al.

2020-Current year OA Pubs

Microfluidic lab-on-a-chip technologies enable the analysis and manipulation of small fluid volumes and particles at small scales and the control of fluid flow and transport processes at the microscale, leading to the development of new methods to address a broad range of scientific and medical challenges. Microfluidic and lab-on-a-chip technologies have made a noteworthy impact in basic, preclinical, and clinical research, especially in hematology and vascular biology due to the inherent ability of microfluidics to mimic physiologic flow conditions in blood vessels and capillaries. With the potential to significantly impact translational research and clinical diagnostics, technical issues and incentive mismatches …

Nurses’ Attitudes And Knowledge Differences Toward Pain In Patients With Sickle Cell Disease, Peggy Boyd

Walden Dissertations and Doctoral Studies

No abstract provided.

Rehabilitation Counselor Interventions On Parental-Disability Acceptance, James Samuel Rothrock

Walden Dissertations and Doctoral Studies

No abstract provided.

Cancer Patients’ Spiritual Well-Being, Religious Coping, And Comfort In Communicating With Physicians, Cheryl Boettger

Walden Dissertations and Doctoral Studies

No abstract provided.

Teachers’ Perceptions Of Contributing Factors To, And Strategies For Addressing, Academic Disengagement Among Minority Middle School Students, Aster Kifle-Thompson

Walden Dissertations and Doctoral Studies

No abstract provided.

Relationship Between Resource Allocation And Financial Viability In Nonprofit Organizations, Martin D. Purvis

Walden Dissertations and Doctoral Studies

No abstract provided.

Quality Improvement In Healthcare: A Practical Guide For Providers (Part 3), Jeremy Ellis

Transformative Medicine

No abstract provided.

Novel Drug Approvals 2023, Emily Wagner, Christina Swiger, Mary Hoang, Maley Zents

Transformative Medicine

This article provides an overview of the novel drugs approved for 2023. The Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) provides standards to drug developers. The CDER sets standards for required data needed in the drug development and application process. Every year a variety of new drugs and biological products are approved. Some are new molecular compounds while others are structurally similar to those already on the market. Therefore, products may not have been used in medical practice previously while others have already been used in practice. This article highlights medications that are new in …

“This Ekg Is Concerning For Ischemia!”, Muhammad M. Zafar

Transformative Medicine

No abstract provided.

Aortic Dissection: The Insidious Menace, Muhammad Umer Riaz Gondal, John Lemoine, Mohammad Baig, Prem Parajuli, Zainab Kiyani, Hamza Khan, Hassam Saif

Transformative Medicine

Introduction:

Aortic dissection represents a critical emergency characterized by the cleavage of aortic wall layers, creating a deceptive false lumen. Associated with high mortality rates, prompt diagnosis and intervention are needed to ensure survival.

Case:

A 63-year-old male with no significant medical history presented to the emergency with two days of worsening mid-sternal chest pain. Upon presentation, he was hemodynamically stable. Blood pressure was 130/85 mm Hg (similar in both arms), heart rate 90 bpm, and saturating 98 % on room air. Physical examination did not reveal any new murmurs. EKG showed normal sinus rhythm, no ischemic changes, and a …

New Onset Dyspnea In A Patient With Pacemaker, What Does The Ecg Tracing Show?, Jakob Nypaver, Robert Libera Do, Arun Kundra, Ravi Choxi

Transformative Medicine

Dual chamber pacemakers are programmed to allow for AV synchrony. Whenever a patient with a dual chamber pacemaker with underlying sinus rhythm presents with AV dissociation, the lack of AV synchrony should be questioned. The authors present a case of new onset dyspnea diagnosed as pacemaker syndrome. The diagnosis was initially delayed due to underlying ventricular paced rhythm as misidentified as normal pacemaker behavior.

A 69-year-old female with a past medical history of 2:1 atrioventricular block status post dual-chamber pacemaker implant presented with complaints of new onset shortness of breath and dyspnea. The ECG showed a ventricular rate of 66 …

Autoimmune Hemolytic Anemia: A Rare Presentation Of Mantle Cell Lymphoma, Ian Garrahy, Shoja Rahimian

Transformative Medicine

Autoimmune hemolytic anemia (AIHA) is a well-recognized phenomenon of non-Hodgkin lymphoma, albeit with only few cases described with mantle cell lymphoma (MCL). The characteristics of such cases can improve understanding and management of AIHA in this type of lymphoma. To that end, we describe herein two cases of patients with MCL who presented with AIHA, with comparison to nine previously described cases in literature.

Metformin Continuation Versus Holding Pre And Post Coronary Angiography With Normal Renal Function: A Systematic Review And Meta-Analysis, Mohammad Hamza, Yasar Sattar, Sadaf Fakhra, Neel Patel, Mubashar Karamat, Saman Razzaq, Aamir Saeed, Khaled M. Harmouch, Islam Elgendy, Mamas Mamas, Anand Prasad, Wael Aljaroudi, Ramesh Daggubati, M Chadi Alraies

Transformative Medicine

Background

It is common practice to withhold metformin prior to cardiac catheterization due to fear of developing lactic acidosis in the setting of contrast-associated acute kidney injury (AKI). The evidence behind this recommendation is currently weak.

Methods

We collected 851 articles from PubMed and Embase, of which 3 met our inclusion criteria. Inclusion criteria were age > 18 years, baseline use of long-term metformin with continued or interrupted metformin use in patients during diagnostic or interventional cardiac catheterization. The outcomes studied were differences between post-catheterization and pre-catheterization serum creatinine (SCr) and glomerular filtration rate (GFR). We excluded studies dealing with patients …

The Impact Of Covid-19 Related Stress On Parenting And Community Engagement In A Small Iowa Community, Danny Trip, Savanna Farley

Research in the Capitol

This study addresses the question, “Does COVID-19-related stress and household income during COVID-19 predict parents’ interactions with children and family community engagement one year later?” The hypothesis was that higher levels of COVID-19-related stress and lower household income would predict more negative interactions between parent and the focal child and less community engagement. The participants within this study were drawn from a larger ongoing study, the Dubuque Youth and Family Resilience Project (DYFRP). Control variables included household income, child’s gender, and child’s age. The independent variable was reported COVID-19 related stress and the dependent variables were community engagement, positive parenting …

Characterization Of Mtdna Minicircles In A Chewing Louse, Geomydoecus Centralis, John Lehmkuhl, Grace Mraz, James W. Demastes, Theresa A. Spradling

Research in the Capitol

The DNA of living organisms is packaged into chromosomes differently in different species, but typically following a standard set of "rules." Understanding how DNA can be packaged for different species provides a better understanding of life and the genetic rules that must be followed, and the "rules" that can be broken. Mitochondria are crucial subcomponents of cells, providing the energy for life. Mitochondria always have their own mtDNA. In our study, we have learned that chewing lice mtDNA differs from that of other animals by spreading the genes across 12 separate small, circular chromosomes instead of one large, circular chromosome. …

Gender Socialization And Social Media In College Students' Fear Of Crime, Ashlyn Miller

Research in the Capitol

The purpose of this study is to explore the relationship between gender, viewing crime related material on social media, and fear of crime experienced by college students. While violent crime rates have fallen, the majority of college students report levels of crime are increasing. Many individuals lack both knowledge and experience related to crime, leading media exposure to influence their levels of fear. Previous research has focused on television media related to fear of crime with little research on social media, the preferred media source of young adults. College students (n = 126) from a midwestern university completed a survey …

An Automated Method To Detect Tooth Brushing Activity With Smartwatch Sensors, Blake Schleter, Marina Avdonina, Rishiraj Adhikary, Dheryta Jaisinghani, Sougata Sen

Research in the Capitol

Nearly half (46%) of all adults aged 30 years or older show signs of gum disease; severe gum disease affects about 9% of adults.

Brushing your teeth is an incredibly important part of taking care of your oral health and daily hygiene. Dentists recommend that you should brush your teeth twice a day for periods of at least two minutes to achieve adequate results and promote oral health.

Currently, there are very limited solutions available to help people easily and efficiently track their tooth brushing activity.

An Argument For Expanding Research On Quantitative Pedagogical Content Knowledge, Randall E. Groth

Numeracy

Pedagogical content knowledge (PCK) traditionally has been used in research concerning prospective and practicing classroom teachers. This essay argues that PCK is also relevant to other professions including those advancing quantitative reasoning (QR). To illustrate, the case of PCK for teaching QR is considered. Those in fields such as public health, journalism, meteorology, and government increasingly find themselves responsible for helping the public understand an ever-growing amount of quantitative information that has a bearing on societal well-being. Several examples illustrate how such professionals’ responsibilities require knowing prevalent QR patterns in society, strategies for fostering sound reasoning, and the general nature …

A Case Study Of Backward Design In A Customized Business English Course For Global Supply Chain Vendors In Francophone Africa, Steven J. Sacco

Global Advances in Business Communication

The present article describes a case study in which the author used domain analysis to create a backward-designed remedial listening comprehension course for global supply chain vendors employed with logistics-focused multinational corporations operating in Francophone Africa. The course is designed to address weaknesses in listening comprehension skills as exhibited by global supply chain vendors in Francophone Africa who work daily with South Asian customers. The weaknesses emanate, in large part, from the existence of World Englishes due to the rise of English as a lingua franca by multinational corporations. World Englishes refers to the existence of “emerging localized or indigenized …

Highly Available Te Path Management For Delegated Paths Across Multiple Pces Without East-West Communication Between Pces, Anonymous

Defensive Publications Series

The present disclosure relates to Traffic Engineering path management with Path Computation Elements (PCEs). Specifically, we allow TE paths to stay in a PCE throughout the entire TE path lifecycle. There is a new “controlling” setting to determine whether the PCE is active for that TE path, allowing the PCE to keep the TE path in its inventory even when it does not have control of the TE path. This uses existing work in the Path Computation Client (PCC) to determine its active and backup PCE by listening to what the PCE Protocol (PCEP) says about delegation of the various …

Lstm-Based Recurrent Neural Network Predicts Influenza-Like-Illness In Variable Climate Zones, Alfred Amendolara, Christopher Gowans, Joshua Barton, David Sant, Andrew Payne

Annual Research Symposium

Purpose: Influenza virus is responsible for a recurrent, yearly epidemic in most temperate regions of the world. For the 2021-2022 season the CDC reports 5000 deaths and 100,000 hospitalizations, a significant number despite the confounding presence of SARS-CoV-2. The mechanisms behind seasonal variance in flu burden are not well understood. Based on a previously validated model, this study seeks to expand understanding of the impact of variable climate regions on seasonal flu trends. To that end, three climate regions have been selected. Each region represents a different ecological region and provides different weather patterns showing how the climate variables impact …

The Role Of Kuwaiti Universities In Developing Awareness Of Political Participation Among Their Students From Students' Point Of View. دور الجامعات الكويتية في تنمية الوعي بالمشاركة السياسية لدى طلبتها من وجهة نظر الطلبة أنفسهم, محمد سليم الزبون, Abdul Aziz Muhammad Al-Rayes

Association of Arab Universities Journal for Education and Psychology

The study aimed to define the reality of the existence of a role for Kuwaiti universities in developing awareness of political participation among their students based on the ideas of Gabriel Almond from the point of view of the students themselves and its relationship to some variables.To achieve the objectives of the study the descriptive survey approach was used.The study sample consisted of (648) male and female students from Kuwait University and the Public Authority for Applied Education. The research relied on a questionnaire as a tool for the study. It consisted of (53) items distributed over three domains.The study …

Death Anxiety And Its Relationship To Social Support Among A Sample Of Elderly People "A Field Study On A Sample Of The Elderly In The Lebanese Beqaa Governorate". قلق الموت وعلاقته بالمساندة الاجتماعية لدى عينة من المسنين د ا رسة ميدانية على عينة من المسنين في محافظة البقاع اللبنانية, Nidal Muhammad Murtada

Association of Arab Universities Journal for Education and Psychology

The research aimed to identify the relationship between death anxiety and its relationship to social support among a sample of elderly people. To detect the differences in death anxiety and social support according to the variable of gender, the researcher relied on the descriptive analytical approach. The research sample consisted of (94) elderly men and women in Beqaa- Lebanon.To achieve the objectives of the research, the death anxiety scale was used. According to Templar, and the social support scale prepared by Spender, 1982.The following results were reached: The level of death anxiety among the members of the research sample was …

Adaptive Leadership During Times Of Great Change And Opportunity: Building Adaptive Capacity As Perceived By Community Emergency Response Team Program Managers, Ramona Gresham

Dissertations

Purpose: The purpose of this phenomenological study was to identify and describe the strategies used by Community Emergency Response Team (CERT) program managers to build an adaptive capacity based on the five key characteristics of adaptive leadership identified by Heifetz et al. (2009).

Methodology: This phenomenological study explored the lived experiences of 1` to build an adaptive capacity. The purposeful, convenience sampling frame was used to identify 10 participants who met the study’s criteria. The semistructured, open-ended interview protocol was developed by a thematic research team of nine peers and three faculty advisors. The data collected from interviews and artifacts …

Governors State Takes Top Advertising Awards, Office Of Marketing And Communications

Newsroom

No abstract provided.