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Articles 178171 - 178200 of 1797706
Full-Text Articles in Entire DC Network
The Transformation Of Social Work In Ukraine Before And During The War, Jaroslaw Richard Romaniuk, Kathleen J. Farkas
The Transformation Of Social Work In Ukraine Before And During The War, Jaroslaw Richard Romaniuk, Kathleen J. Farkas
Faculty Scholarship
Background: This article aims to review the development of the social work profession in Ukraine and to describe the impact of social, economic and political changes on social work practices and education. Methods: A comprehensive literature review and participant observation methods informed this study. A case study of a Polish community’s response to Ukrainian war refugees illustrates how social workers might capitalize on current social structures to continue strengthening civil society in Ukraine. Findings and Discussion: Social Work, focusing on the fit between person and environment, is shaped by knowledge, culture and belief systems. Ukraine’s history and transition from communist/centralized …
Cross-Cousin Marriage Among Tsimane Forager–Horticulturalists During Demographic Transition And Market Integration, Arianna Dalzero, Bret A. Beheim, Hillard Kaplan, Jonathan Stieglitz, Paul L. Hooper, Cody T. Ross, Michael D. Gurven, Dieter Lukas
Cross-Cousin Marriage Among Tsimane Forager–Horticulturalists During Demographic Transition And Market Integration, Arianna Dalzero, Bret A. Beheim, Hillard Kaplan, Jonathan Stieglitz, Paul L. Hooper, Cody T. Ross, Michael D. Gurven, Dieter Lukas
ESI Publications
Although still prevalent in many human societies, the practice of cousin marriage has precipitously declined in populations undergoing rapid demographic and socioeconomic change. However, it is still unclear whether changes in the structure of the marriage pool or changes in the fitness-relevant consequences of cousin marriage more strongly influence the frequency of cousin marriage. Here, we use genealogical data collected by the Tsimane Health and Life History Project to show that there is a small but measurable decline in the frequency of first cross-cousin marriage since the mid-twentieth century. Such changes are linked to concomitant changes in the pool of …
An Examination Of Credit Accrual And Graduation Rates Through The Modalities Of Instruction In An Online Learning Environment, Jennifer L. Wilkinson
An Examination Of Credit Accrual And Graduation Rates Through The Modalities Of Instruction In An Online Learning Environment, Jennifer L. Wilkinson
Student Theses and Dissertations
The problem addressed in this study was the high dropout rate and the resulting low graduation rate in alternative virtual school settings. This quantitative correlational case study examined the influence of three instructional modalities on students’ credit accrual and graduation rates in one alternative education virtual high school. The three modalities of instruction included a synchronous pathway, an asynchronous pathway, and a combination of synchronous and asynchronous instructional delivery. The lens of connectivism learning theory served as the theoretical framework that supports understanding the relationships between different modalities of instruction and students’ learning outcomes (e.g., accrual rates and graduation rates) …
Articulation Versus Motor Speech? Supervisor Perspectives Of Slp Graduate Students: A Qualitative Study, Maddison Verser
Articulation Versus Motor Speech? Supervisor Perspectives Of Slp Graduate Students: A Qualitative Study, Maddison Verser
Student Theses and Dissertations
This qualitative study was to determine clinical supervisors' perceptions of graduate students’ skill set of articulation disorders compared to motor speech disorders. Participants in this study included SLP clinical supervisors of Master’s level graduate students in Communication Disorders across various pediatric settings, including private practice, school-based or outpatient clinics in north central Arkansas. Face-to-face/phone interviews were recorded with a digital recorder and transcribed using the speech-to-text transcription service at Temi.com. The data were analyzed by the primary investigator to identify concepts and themes. The results of this study showed three main themes: (1) students are perceived as more independent and …
Hearing Loss Vs Length Of Employment In The Steel Industry, Sarah Jane Hattle
Hearing Loss Vs Length Of Employment In The Steel Industry, Sarah Jane Hattle
Student Theses and Dissertations
The purpose of this research was to investigate if there was a relationship between hearing loss and length of employment in the steel industry. Participants included 11 males that worked in the steel industry. Participants completed questionnaires regarding demographics, employment, and noise exposure, as well as took part in an audiological exam. The results of the audiological evaluations showed that 45% of participants had hearing loss in the right ear, 36% of participants had hearing loss in the left ear, and 36% of participants had loss in both ears. While there was no significant relationship between hearing loss and the …
Influence Of Professional Learning Communities On Teachers’ Stress: A Case Study, Jason Young
Influence Of Professional Learning Communities On Teachers’ Stress: A Case Study, Jason Young
Student Theses and Dissertations
Teachers are opting to exit the profession at an unprecedented rate. This trend has led to hiring shortages and the state department lowering licensure standards in the State of Arkansas. The increase in job demands placed on teachers has led to elevated stress levels among educators, ultimately driving them to abandon the field altogether. The current qualitative case study was to explore teachers’ perspectives on the influence professional learning communities (PLCs) can have in reducing job-related stress. The job-demands resource (JD-R) model, which explains how the job-demands cause teacher stress and make it possible to understand teachers’ perceptions of PLCs …
Examining The Influence Of Teacher And Student Variables On Teachers’ Levels Of Self-Efficacy, Rachel Pugh
Examining The Influence Of Teacher And Student Variables On Teachers’ Levels Of Self-Efficacy, Rachel Pugh
Student Theses and Dissertations
The purpose of this descriptive correlational quantitative study was to examine contributing factors of students and teachers affecting teacher self-efficacy and students' reading achievement in rural Oklahoma elementary schools in grades first through fifth. The contributing factors of students being analyzed included (a) poverty and (b) race or ethnic backgrounds. The teachers’ contributing factors include their self-efficacy levels on students' reading achievement, instructional strategies, classroom management, and student engagement levels. The proposed theory was that student and teacher variables beyond their control influenced teachers' self-efficacy levels in poverty-stricken classrooms. The study employed a quantitative approach, which used an online questionnaire …
Biological Significances Of Environmental Pollution In The New Calabar River, Southern Nigeria: A Case Study In Zooplankton Composition, Ibienebo Davies Imachrist, Francis David Sikoki, Philomina Kika, Davies Ibienebo Chris
Biological Significances Of Environmental Pollution In The New Calabar River, Southern Nigeria: A Case Study In Zooplankton Composition, Ibienebo Davies Imachrist, Francis David Sikoki, Philomina Kika, Davies Ibienebo Chris
Journal of Bioresource Management
The study was conducted for three months (May to July 2020), focusing on the physicochemical parameters and zooplankton composition in the Ogbogoro region of the New Calabar River in Nigeria. This investigation was carried out at three distinct monitoring stations. The physicochemical parameters were determined using standard ecological analytic procedures. PAST and SPSS were used for the statistical analysis. The temperature ranged between 26.5 to 33 ºC, salinity (1.23 to 1.86 %), pH (7.4 to 9.62), Total Dissolved Solids (2419 to 5,817 mg/L), conductivity (223.83 to 7,328 μS/cm), turbidity (3.415 to 15.05 NTU) and Dissolved Oxygen (3.8 to 6.8 mg/L). …
The Effect Of Virtual Standardized Patient Integrated Health Coach Training On Professional Confidence Gain In Veterans Health Administration Primary Care Nurses, David Mullins
Graduate Theses, Dissertations, and Capstones
Poor health behaviors cost the United States billions of dollars and tens of thousands of lives every year. The Veterans Affairs primary care delivery model uses health coaching as a catalyst to improve health behaviors in veterans. Health coaching is a complex skill that requires specialized training, repetitive practice, and professional confidence. Albert Bandura believed most people acquire skills and develop the confidence to use those skills through social learning. He posited that professional confidence played a critical role in skill acquisition, and people with low professional confidence were less likely to attempt to perform a skill. Bandura’s Theory of …
Impact Of Infestation Of Flour By Stored Food Pest Insects Ephestia Kuehniella On Quality Flour: Physico-Chemical Analyses, Hadjira Bendjedid, Samira Yezli-Touiker, Asma Taffar, Amina Yezli, Nabila Souileh
Impact Of Infestation Of Flour By Stored Food Pest Insects Ephestia Kuehniella On Quality Flour: Physico-Chemical Analyses, Hadjira Bendjedid, Samira Yezli-Touiker, Asma Taffar, Amina Yezli, Nabila Souileh
Journal of Bioresource Management
The primary reason for significant post-harvest losses globally stems from the infestation of insect pests. These beetles, as they progress through their life cycle, lead to the deterioration of stored food, capable of decimating an entire inventory within a remarkably brief timeframe. Quality control is a system that monitors product quality, assuring and detecting any spoilage of a product, the impact of infestation of flour by pairs of stored food pest insects E. kuehniella on quality flour was evaluated by physicochemical analyses over time. Provoked exposure of 200 g of flour to 5, 10, and 20 couples of Ephestia keuhniella …
Usage Of Almond And Thyme Oils For The Enhancement Of Shelf Life Of Different Fish Species, Aneeza Kanwal, Roheela Yasmeen, Saima Nazir, Shumaila Usman, Bushra Nisar Khan
Usage Of Almond And Thyme Oils For The Enhancement Of Shelf Life Of Different Fish Species, Aneeza Kanwal, Roheela Yasmeen, Saima Nazir, Shumaila Usman, Bushra Nisar Khan
Journal of Bioresource Management
Fish is an important source of protein for millions of people around the globe and it's often a healthier option compared to some other meats. However, the fish industry is facing a storage challenge in the form of rapid spoilage and deterioration of freshness due to bacterial growth and enzymatic activity. The usage of oils in fish can enhance shelf life by creating a protective barrier. This research was designed to see the effects of thyme and almond oil on nutritional profile and shelf life of fish. The three fish species rohu (Labeo rohita), Mali (Wallago attu) …
Biomarkers For Managing Neurodegenerative Diseases, Lara Cheslow, Adam E. Snook, Scott A. Waldman
Biomarkers For Managing Neurodegenerative Diseases, Lara Cheslow, Adam E. Snook, Scott A. Waldman
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
Neurological disorders are the leading cause of cognitive and physical disability worldwide, affecting 15% of the global population. Due to the demographics of aging, the prevalence of neurological disorders, including neurodegenerative diseases, will double over the next two decades. Unfortunately, while available therapies provide symptomatic relief for cognitive and motor impairment, there is an urgent unmet need to develop disease-modifying therapies that slow the rate of pathological progression. In that context, biomarkers could identify at-risk and prodromal patients, monitor disease progression, track responses to therapy, and parse the causality of molecular events to identify novel targets for further clinical investigation. …
Hesitation Towards The Covid-19 Vaccine In The United States: A Digital Ethnographic Study [Vacilación Ante La Vacuna Contra El Covid-19 En Estados Unidos De América: Un Estudio Etnográfico Digital], Rosalynn A. Vega
Anthropology Faculty Publications
Following the authorization of the use of COVID-19 vaccines in babies age 6 months through children 4 years old in the United States, some individuals (parents, pediatricians, and communicators) framed COVID-19 vac-cination as an issue of access, while many others expressed hesitancy, and some resisted recommendations from the US Centers for Disease Control and Prevention. In this context, this study aimed to explore: 1) divergent reactions to the authorization of COVID-19 vaccine use in children aged 6 months to 4 years; and 2) opposing logics underlying attitudes towards pro-vaccination, anti-vaccination, and vaccine hesitancy regarding COVID-19 vaccines. To achieve this, a …
Book Review Of Hadley Vlahos. 2023. The In-Between; Unforgettable Encounters During Life’S Final Moments. Ballantine Books: New York, Roger Clark, Emily Stier Adler
Book Review Of Hadley Vlahos. 2023. The In-Between; Unforgettable Encounters During Life’S Final Moments. Ballantine Books: New York, Roger Clark, Emily Stier Adler
Sociology Between the Gaps: Forgotten and Neglected Topics
No abstract provided.
Amino Acid Formula Induces Microbiota Dysbiosis And Depressive-Like Behavior In Mice, Ji Hu, Kaixin He, Yifei Yang, Chuan Huang, Yiping Dou, Hao Wang, Guorong Zhang, Jingyuan Wang, Chaoshi Niu, Guoqiang Bi, Lan Zhang, Shu Zhu
Amino Acid Formula Induces Microbiota Dysbiosis And Depressive-Like Behavior In Mice, Ji Hu, Kaixin He, Yifei Yang, Chuan Huang, Yiping Dou, Hao Wang, Guorong Zhang, Jingyuan Wang, Chaoshi Niu, Guoqiang Bi, Lan Zhang, Shu Zhu
Faculty, Staff and Student Publications
Amino acid formula (AAF) is increasingly consumed in infants with cow's milk protein allergy; however, the long-term influences on health are less described. In this study, we established a mouse model by subjecting neonatal mice to an amino acid diet (AAD) to mimic the feeding regimen of infants on AAF. Surprisingly, AAD-fed mice exhibited dysbiotic microbiota and increased neuronal activity in both the intestine and brain, as well as gastrointestinal peristalsis disorders and depressive-like behavior. Furthermore, fecal microbiota transplantation from AAD-fed mice or AAF-fed infants to recipient mice led to elevated neuronal activations and exacerbated depressive-like behaviors compared to that …
Effective Strategies For Improving Supply Chains' Resilience And Cost Effectiveness, Felix Louis Fidelibus
Effective Strategies For Improving Supply Chains' Resilience And Cost Effectiveness, Felix Louis Fidelibus
Walden Dissertations and Doctoral Studies
No abstract provided.
Correction: The Novel Phosphatase Nudt5 Is A Critical Regulator Of Triple-Negative Breast Cancer Growth, Jing Qian, Yanxia Ma, William M Tahaney, Cassandra L Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, Negar Koupaei, Susan G Hilsenbeck, Michelle I Savage, Brent D G Page, Abhijit Mazumdar, Powel H Brown
Correction: The Novel Phosphatase Nudt5 Is A Critical Regulator Of Triple-Negative Breast Cancer Growth, Jing Qian, Yanxia Ma, William M Tahaney, Cassandra L Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, Negar Koupaei, Susan G Hilsenbeck, Michelle I Savage, Brent D G Page, Abhijit Mazumdar, Powel H Brown
Faculty, Staff and Student Publications
No abstract provided.
Author Correction: Cytoskeleton Remodeling Induced By Smyd2 Methyltransferase Drives Breast Cancer Metastasis, Alexandre G Casanova, Gael S Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J M Bischoff, Emilie M Froeliger, Lucid Belmudes, Ekaterina Bourova-Flin, Natasha M Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K Mazur, Nicolas Reynoird
Author Correction: Cytoskeleton Remodeling Induced By Smyd2 Methyltransferase Drives Breast Cancer Metastasis, Alexandre G Casanova, Gael S Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J M Bischoff, Emilie M Froeliger, Lucid Belmudes, Ekaterina Bourova-Flin, Natasha M Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K Mazur, Nicolas Reynoird
Faculty, Staff and Student Publications
No abstract provided.
Integration Of Kupffer Cells Into Human Ipsc-Derived Liver Organoids For Modeling Liver Dysfunction In Sepsis, Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi
Integration Of Kupffer Cells Into Human Ipsc-Derived Liver Organoids For Modeling Liver Dysfunction In Sepsis, Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi
Faculty, Staff and Student Publications
Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs containing Kupffer cells (KuLOs) by recapitulating fetal liver hematopoiesis using human induced pluripotent stem cell (hiPSC)-derived erythro-myeloid progenitors (EMPs), the origin of tissue-resident macrophages, and hiPSC-derived LOs. Remarkably, LOs actively promote EMP hematopoiesis toward myeloid and erythroid lineages. Moreover, supplementing with macrophage colony-stimulating factor (M-CSF) proves crucial in sustaining the hematopoietic population during the establishment of KuLOs. Exposing KuLOs to sepsis-like endotoxins leads to significant …
A Novel Machine Learning Algorithm Selects Proteome Signature To Specifically Identify Cancer Exosomes, Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
A Novel Machine Learning Algorithm Selects Proteome Signature To Specifically Identify Cancer Exosomes, Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
Faculty, Staff and Student Publications
Non-invasive early cancer diagnosis remains challenging due to the low sensitivity and specificity of current diagnostic approaches. Exosomes are membrane-bound nanovesicles secreted by all cells that contain DNA, RNA, and proteins that are representative of the parent cells. This property, along with the abundance of exosomes in biological fluids makes them compelling candidates as biomarkers. However, a rapid and flexible exosome-based diagnostic method to distinguish human cancers across cancer types in diverse biological fluids is yet to be defined. Here, we describe a novel machine learning-based computational method to distinguish cancers using a panel of proteins associated with exosomes. Employing …
Feminization Of Responsibility In Community Recovery: Rethinking Disaster Justice Through The Lens Of Care, Kaira Zoe; Alburo-Cañete
Feminization Of Responsibility In Community Recovery: Rethinking Disaster Justice Through The Lens Of Care, Kaira Zoe; Alburo-Cañete
Philippine Studies: Historical and Ethnographic Viewpoints
In the Philippines women are increasingly recognized for their crucial roles in disaster recovery. While not against participation per se, thisarticle troubles assumptions tied to women’s participation, which are based on constructions of women’s altruism and care responsibilities. Drawing from a qualitative case study in post-Yolanda Tacloban, it contends that instrumentalizing women’s care-based practices in disasters may inadvertently worsen gender inequalities. To achieve gender justice in recovery, thearticle advocates addressing the confinement of care to women and emphasizes integrating an ethics of care into disaster justice frameworks to combat pervasive injustices that contribute to gendered vulnerabilities during disasters.KEYWORDS: DISASTER JUSTICE …
Confidence In Crises: School Nurses' Perceptions Of Self-Efficacy In Active Shooter Emergency Preparedness, Titilayo Idowu
Confidence In Crises: School Nurses' Perceptions Of Self-Efficacy In Active Shooter Emergency Preparedness, Titilayo Idowu
Dissertations
The incidence and number of mass school shootings have increased since the first reported school shooting in 1840. Since then, extensive research has been conducted to explore school violence's underlying causes and precursors, resulting in many recommendations for preventative and mitigating practices. However, no national standard or legislation currently dictates the minimal requirements for competencies and training among school nurses in preparation for active shooter incidents. This interpretive qualitative phenomenological study was conducted to explore the lived experiences of postlicensure K-12 school nurses regarding their self-efficacy and confidence to prevent, protect, mitigate, respond, and recover from a school shooting incident. …
Effect Of Early Vs Late Inguinal Hernia Repair On Serious Adverse Event Rates In Preterm Infants: A Randomized Clinical Trial, Martin L Blakely, Andrea Krzyzaniak, Melvin S Dassinger, Claudia Pedroza, Jorn-Hendrik Weitkamp, Ankush Gosain, Michael Cotten, Susan R Hintz, Henry Rice, Sherry E Courtney, Kevin P Lally, Namasivayam Ambalavanan, Catherine M Bendel, Kim Chi T Bui, Casey Calkins, Nicole M Chandler, Roshni Dasgupta, Jonathan M Davis, Katherine Deans, Daniel A Deugarte, Jeffrey Gander, Carl-Christian A Jackson, Martin Keszler, Karen Kling, Stephen J Fenton, Kimberley A Fisher, Tyler Hartman, Eunice Y Huang, Saleem Islam, Frances Koch, Shabnam Lainwala, Aaron Lesher, Monica Lopez, Meghna Misra, Jamie Overbey, Brenda Poindexter, Robert Russell, Steven Stylianos, Douglas Y Tamura, Bradley A Yoder, Donald Lucas, Donald Shaul, P Ben Ham, Colleen Fitzpatrick, Kara Calkins, Aaron Garrison, Diomel De La Cruz, Shahab Abdessalam, Charlotte Kvasnovsky, Bradley J Segura, Joel Shilyansky, Lynne M Smith, Jon E Tyson
Effect Of Early Vs Late Inguinal Hernia Repair On Serious Adverse Event Rates In Preterm Infants: A Randomized Clinical Trial, Martin L Blakely, Andrea Krzyzaniak, Melvin S Dassinger, Claudia Pedroza, Jorn-Hendrik Weitkamp, Ankush Gosain, Michael Cotten, Susan R Hintz, Henry Rice, Sherry E Courtney, Kevin P Lally, Namasivayam Ambalavanan, Catherine M Bendel, Kim Chi T Bui, Casey Calkins, Nicole M Chandler, Roshni Dasgupta, Jonathan M Davis, Katherine Deans, Daniel A Deugarte, Jeffrey Gander, Carl-Christian A Jackson, Martin Keszler, Karen Kling, Stephen J Fenton, Kimberley A Fisher, Tyler Hartman, Eunice Y Huang, Saleem Islam, Frances Koch, Shabnam Lainwala, Aaron Lesher, Monica Lopez, Meghna Misra, Jamie Overbey, Brenda Poindexter, Robert Russell, Steven Stylianos, Douglas Y Tamura, Bradley A Yoder, Donald Lucas, Donald Shaul, P Ben Ham, Colleen Fitzpatrick, Kara Calkins, Aaron Garrison, Diomel De La Cruz, Shahab Abdessalam, Charlotte Kvasnovsky, Bradley J Segura, Joel Shilyansky, Lynne M Smith, Jon E Tyson
Faculty, Staff and Student Publications
Importance: Inguinal hernia repair in preterm infants is common and is associated with considerable morbidity. Whether the inguinal hernia should be repaired prior to or after discharge from the neonatal intensive care unit is controversial.
Objective: To evaluate the safety of early vs late surgical repair for preterm infants with an inguinal hernia.
Design, setting, and participants: A multicenter randomized clinical trial including preterm infants with inguinal hernia diagnosed during initial hospitalization was conducted between September 2013 and April 2021 at 39 US hospitals. Follow-up was completed on January 3, 2023.
Interventions: In the early repair strategy, infants underwent inguinal …
The George-Anne Inkwell Edition, Georgia Southern University
The George-Anne Inkwell Edition, Georgia Southern University
The Inkwell
No abstract provided.
Knowing The Patient As A Person: Social Media Listening And Gadamerian Analysis Of Nurses' Expressions Shared During The Covid-19 Global Health Pandemic, Janusz A. Kaleta
Knowing The Patient As A Person: Social Media Listening And Gadamerian Analysis Of Nurses' Expressions Shared During The Covid-19 Global Health Pandemic, Janusz A. Kaleta
Dissertations
COVID-19 has dramatically changed human-to-human interactions from in-person to the nonhuman domain of virtual space. In January 2021, every 28 seconds one person died of COVID-19 in the United States. An average of 3,100 Americans died each day during the deadliest month of the pandemic. As of January 2023, the number of COVID-19 deaths in the USA surpassed 1.000.000 people. In hospitals, human-to-human interactions were often limited to seeing one's eyes behind the face shields, and respirator masks, and hearing a muffled voice, or sounds of the ventilators. In New York State 452 nurses died during the pandemic.
What does …
Discovery Of Sqstm1/P62-Dependent P-Bodies That Regulate The Nlrp3 Inflammasome, Elizabeth R. Barrow, Evelina Valionyte, Chris R. Baxter, Yi Yang, Sharon Herath, William A. O'Connell, Justyna Lopatecka, Alexander Strachan, Waldemar Woznica, Holly N. Stephenson, Gyorgy Fejer, Vikram Sharma, Boxun Lu, Shouqing Luo
Discovery Of Sqstm1/P62-Dependent P-Bodies That Regulate The Nlrp3 Inflammasome, Elizabeth R. Barrow, Evelina Valionyte, Chris R. Baxter, Yi Yang, Sharon Herath, William A. O'Connell, Justyna Lopatecka, Alexander Strachan, Waldemar Woznica, Holly N. Stephenson, Gyorgy Fejer, Vikram Sharma, Boxun Lu, Shouqing Luo
School of Biomedical Sciences
Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles in selective autophagy; however, it is unknown whether p62 can exist as another form in addition to its autophagic droplets. Here, we found that, under stress conditions, including proteotoxicity, endotoxicity, and oxidation, autophagic p62 droplets are transformed to a type of enlarged PBs, termed p62-dependent P-bodies (pd-PBs). p62 phase separation is essential for the nucleation of pd-PBs. Mechanistically, pd-PBs are triggered by enhanced p62 droplet formation upon stress stimulation through the interactions …
Identifying Potential Dietary Treatments For Inherited Metabolic Disorders Using Drosophila Nutrigenomics, Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K Barlow, Jefferson Paril, Ralf B Schittenhelm, John Christodoulou, Hugo J Bellen, Matthew D W Piper, Travis K Johnson
Identifying Potential Dietary Treatments For Inherited Metabolic Disorders Using Drosophila Nutrigenomics, Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K Barlow, Jefferson Paril, Ralf B Schittenhelm, John Christodoulou, Hugo J Bellen, Matthew D W Piper, Travis K Johnson
Faculty, Staff and Students Publications
Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders respond to dietary treatment; however, this option remains largely unexplored because of low disorder prevalence and the lack of a suitable paradigm for testing diets. Here, we screened 35 Drosophila amino acid disorder models for disease-diet interactions and found 26 with diet-altered development and/or survival. Using a targeted multi-nutrient array, we examine the interaction in a model of isolated sulfite oxidase deficiency, an infant-lethal disorder. We show that dietary cysteine depletion normalizes their metabolic profile and rescues development, neurophysiology, …
Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Helehan Borrow Material Submittal #2 (Dated March 12, 2024), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Exploring The Associations Between Drug Resistant Mutations, Low-Level Viremia, And Virological Failure In Persons With Hiv In Florida, Adriana Campos
Exploring The Associations Between Drug Resistant Mutations, Low-Level Viremia, And Virological Failure In Persons With Hiv In Florida, Adriana Campos
USF Tampa Graduate Theses and Dissertations
Virologic suppression is an essential part to a successful regimen for Persons with HIV (PWH) and the 95-95-95 initiative. Yet, PWH experiencing episodes of low-level viremia (LLV) may be more prone to experience virological failure (VF). Currently, studies debate the clinical relevance of LLV and its effect on virological outcomes, but none have explored its interconnectedness with drug resistant mutations (DRM) and antiretroviral treatment (ART) adherence – all integral elements in predicting virological outcomes.
The goal of the proposed study was to contribute to the knowledge gap regarding the interconnectivity of drug resistant mutations, low-level viremia, adherence, and virological failure …
Community-Centered Early Warning For Outbreaks In Humanitarian Emergencies: Evaluating Community-Based Surveillance For Priority Communicable Diseases Among Internally Displaced Populations In Iraq, Caitlin M. Wolfe
USF Tampa Graduate Theses and Dissertations
Background: Community based surveillance (CBS) is the organized and rapid collection of information from health events identified in the community and includes the systematic detection and reporting of events of public health significance. While used globally to enhance the detection of priority diseases, CBS has not been routinely deployed in Iraq, where a once-robust health system has been devastated by decades of war, international sanctions, and large-scale population displacement. During infectious disease outbreaks, it is imperative to quickly detect and isolate suspect cases, investigate confirmed cases, and trace and monitor the contacts of confirmed cases. The COVID-19 pandemic underscored the …