Digital Commons Network^™

Dissection, Histological Processing, And Gene Expression Analysis Of Murine Supraclavicular Brown Adipose Tissue, Mark G Waterstraat, Ziyi Wang, Mari Kogiso, Rommel Caballero-Juarez, Miao-Hsueh Chen

Children’s Nutrition Research Center Staff Publications

Brown adipose tissue (BAT)-mediated thermogenesis plays an important role in the regulation of metabolism, and its morphology and function can be greatly impacted by environmental stimuli in mice and humans. Currently, murine interscapular BAT (iBAT), which is located between two scapulae in the upper dorsal flank of mice, is the main BAT depot used by research laboratories to study BAT function. Recently, a few previously unknown BAT depots were identified in mice, including one analogous to human supraclavicular brown adipose tissue. Unlike iBAT, murine supraclavicular brown adipose tissue (scBAT) is situated in the intermediate layer of the neck and thus …

Ndrgs In Breast Cancer: A Review And In Silico Analysis, Emilly S Villodre, Anh P N Nguyen, Bisrat G Debeb

Faculty, Staff and Student Publications

Simple Summary

Breast cancer is the most common cancer in women and one of the deadliest. While survival rates for patients with breast cancer have seen notable improvements in recent decades, current treatment strategies still face significant limitations, especially for patients with aggressive, therapy-resistant, and metastatic breast cancers. For this reason, it is important to identify new targets in order to develop more effective therapeutic strategies. The N-myc downstream regulated gene family (NDRGs), comprising NDRG1, NDRG2, NDRG3, and NDRG4, has been previously described as tumor suppressors. However, recent findings challenge this perception, particularly for NDRG1, …

Pre-Covid-19 Hospital Quality And Hospital Response To Covid-19: Examining Associations Between Risk-Adjusted Mortality For Patients Hospitalised With Covid-19 And Pre-Covid-19 Hospital Quality, Doris Peter, Shu-Xia Li, Yongfei Wang, Jing Zhang, Jacqueline Grady, Kerry Mcdowell, Erica Norton, Zhenqiu Lin, Susannah Bernheim, Arjun K Venkatesh, Lee A Fleisher, Michelle Schreiber, Lisa G Suter, Elizabeth W Triche

Faculty, Staff and Student Publications

OBJECTIVES: The extent to which care quality influenced outcomes for patients hospitalised with COVID-19 is unknown. Our objective was to determine if prepandemic hospital quality is associated with mortality among Medicare patients hospitalised with COVID-19.

DESIGN: This is a retrospective observational study. We calculated hospital-level risk-standardised in-hospital and 30-day mortality rates (risk-standardised mortality rates, RSMRs) for patients hospitalised with COVID-19, and correlation coefficients between RSMRs and pre-COVID-19 hospital quality, overall and stratified by hospital characteristics.

SETTING: Short-term acute care hospitals and critical access hospitals in the USA.

PARTICIPANTS: Hospitalised Medicare beneficiaries (Fee-For-Service and Medicare Advantage) age 65 and older hospitalised …

Childcare Center Principals’ Decision-Making Regarding Participation In A Quality Assurance Program, Rosa M. Flores

Walden Dissertations and Doctoral Studies

No abstract provided.

Visual Analysis Of Bone Malignancies Immunotherapy: A Bibliometric Analysis From 2010 To 2023, Kaiyu Shen, Liu Yang, Shuaiyi Ke, Wencang Gao

Faculty, Staff and Student Publications

Background: Bone malignancies (BM), including osteosarcoma, Ewing's sarcoma, chondrosarcoma, and chordoma, are characterized by high rates of recurrence and mortality, despite the availability of diverse treatment approaches. Immunotherapy has gained increasing importance in cancer treatment. However, there is a lack of comprehensive studies that utilize bibliometric analysis to explore immunotherapy for BM.

Methods: A literature search of English studies on BM and immunotherapy from 2010 to 2023 was conducted in the Web of Science Core Collection database. Bibliometric analysis tools such as VOSviewer, CiteSpace, and R Studio were utilized to examine global trends and research hotspots in this field.

Results: …

Regional Analysis To Delineate Intrasample Heterogeneity With Regionalst, Yue Lyu, Chong Wu, Wei Sun, Ziyi Li

Faculty, Staff and Student Publications

MOTIVATION: Spatial transcriptomics has greatly contributed to our understanding of spatial and intra-sample heterogeneity, which could be crucial for deciphering the molecular basis of human diseases. Intra-tumor heterogeneity, e.g. may be associated with cancer treatment responses. However, the lack of computational tools for exploiting cross-regional information and the limited spatial resolution of current technologies present major obstacles to elucidating tissue heterogeneity.

RESULTS: To address these challenges, we introduce RegionalST, an efficient computational method that enables users to quantify cell type mixture and interactions, identify sub-regions of interest, and perform cross-region cell type-specific differential analysis for the first time. Our simulations …

Activation Of Endogenous Retroviruses And Induction Of Viral Mimicry By Mek1/2 Inhibition In Pancreatic Cancer, Alice Cortesi, Francesco Gandolfi, Fabiana Arco, Pierluigi Di Chiaro, Emanuele Valli, Sara Polletti, Roberta Noberini, Francesco Gualdrini, Sergio Attanasio, Francesca Citron, I-Lin Ho, Rutvi Shah, Er-Yen Yen, Mara Cetty Spinella, Simona Ronzoni, Simona Rodighiero, Nico Mitro, Tiziana Bonaldi, Serena Ghisletti, Silvia Monticelli, Andrea Viale, Giuseppe Riccardo Diaferia, Gioacchino Natoli

Faculty, Staff and Student Publications

While pancreatic ductal adenocarcinomas (PDACs) are addicted to KRAS-activating mutations, inhibitors of downstream KRAS effectors, such as the MEK1/2 kinase inhibitor trametinib, are devoid of therapeutic effects. However, the extensive rewiring of regulatory circuits driven by the attenuation of the KRAS pathway may induce vulnerabilities of therapeutic relevance. An in-depth molecular analysis of the transcriptional and epigenomic alterations occurring in PDAC cells in the initial hours after MEK1/2 inhibition by trametinib unveiled the induction of endogenous retroviruses (ERVs) escaping epigenetic silencing, leading to the production of double-stranded RNAs and the increased expression of interferon (IFN) genes. We tracked ERV activation …

Using Dematel, Clustering, And Fuzzy Logic For Supply Chain Evaluation Of Electric Vehicles: A Scor Model, Mehrbakhsh Nilashi, Rabab Ali Abumalloh, Hossein Ahmadi, Mesfer Alrizq, Hamad Abosaq, Abdullah Alghamdi, Murtaza Farooque, Syed Salman Mahmood

School of Nursing and Midwifery

The transportation sector is considered among the major sources of greenhouse gas emissions. Given advancements in transportation technology, customers’ willingness to reduce carbon footprints, as well as policy incentives, Electric Vehicles (EVs) are becoming an increasingly important part of the passenger vehicle industry. Evaluation of Supply Chain (SC) performance in the EV industry seems to contribute significantly to the enhancement of the operational consequences across the supply chain tiers. The SCOR (Supply Chain Operations Reference) model was designed to help businesses optimize their supply chain operations, reduce costs, and improve customer satisfaction. Although many performance measurement models have been developed …

Performance Of A Novel Structural Insulated Panel In Tropical Climates: Experimental And Numerical Studies, Thanongsak Imjai, Fetih Kefyalew, Reyes Garcia, Boksun Kim, Ana Bras, Piti Sukontasukkul

School of Engineering, Computing and Mathematics

This article investigates experimentally and numerically the thermal performance of a new type of structural insulated panel (SIP) termed ‘UWall’. The panel core consists of an ad-hoc waffle skeleton of Expanded Polystyrene (EPS), EPS beads mixed with cement mortar (Portland cement type I and recycled concrete aggregate), and two external water-proof cement boards. The experimental programme examined the panels in three Phases. In Phase 1, 200×200×100 mm block specimens were exposed to a temperature of 70°C for 12 hrs. It was found that the new UWall specimens had a better thermal performance (by up to 20%) over other types of …

Devimistat Plus Chemotherapy Vs Chemotherapy Alone For Older Relapsed Or Refractory Patients With Aml: Results Of The Armada Trial, Timothy Pardee, Bayard Powell, Richard Larson, Joseph Maly, Michael Keng, Matthew Foster, Eun-Ji Choi, Heinz Sill, Thomas Cluzeau, Deepa Jeyakumar, Olga Frankfurt, Prapti Patel, Michael Schuster, Elisabeth Koller, Regis Costello, Uwe Platzbecker, Pau Montesinos, Susana Vives, Aziz Nazha, Rachel Cook, Carlos Vigil-Gonzales, Sylvain Chantepie, Sanjeev Luther, Jorge Cortes

Department of Medical Oncology Faculty Papers

Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage. Outcomes in older patients are poor, with high rates of resistant and relapsed disease. Devimistat is a lipoic acid analog that inhibits mitochondrial metabolism. Devimistat combined with high-dose cytarabine and mitoxantrone resulted in promising phase 1 and 2 response rates especially in older patients. Therefore, the phase 3 ARMADA 2000 trial was conducted in patients aged ≥50 years with relapsed or refractory AML. The study randomized patients between devimistat combined with high-dose cytarabine and mitoxantrone (CHAM) or 1 of 3 control treatment regimens without devimistat: high-dose cytarabine and …

It's In The "Weeds" : 'Pesky' Plants As Teachers In Imagining Decolonial Futures, Sofia Ahmad Cook

Tapestries: Interwoven voices of local and global identities

As a category of plant species, “weeds” are often thought of as ‘pesky’ nuisances and treated with absolute disdain. But what are “weeds” and how did they become “pests” that homeowners, gardeners, and conservationists alike seek to control and/or eliminate? My inquiry into “weeds” reveals that the designation of “weeds” is not scientific so much as it is socially and culturally constructed. The categorization of “weeds,” shaped by evolving notions of place, space, and belonging, provides a window into underlying social and cultural norms that structure our relationships with one another and the more-than-human world. Situated within settler colonial contexts, …

Abolish R(Ice): (Dis)Ability, Immigration, And Asian American Resistance, Vivian S. Tran

Tapestries: Interwoven voices of local and global identities

In 2021, Minneapolis-based Khmer artist, Kat Eng designed the “Abolish r(ICE)” t-shirt as part of a fundraiser for Southeast Asians and their families experiencing deportation. Inspired by the iconic Three Ladies Brand jasmine rice bag, Eng re-imagined the three ladies as freedom fighters in response to heightened immigration policing and detention of Southeast Asian communities. In this paper, I unpack and contextualize the Abolish r(ICE) t-shirt campaign within immigration debates, the contemporary abolitionist movement, and Asian American resistance. The Abolish r(ICE) shirts also function as a form of political education and an invitation specifically to Asian American youth to learn …

When Words Fail: The Use And Misuse Of Narratives In The Prison Abolition Movement, Nora De Rege

Tapestries: Interwoven voices of local and global identities

Inspired in part by my experiences at that internship, and a newfound appreciation for the impact of stories, this paper explores the role of narratives in the way we talk and think about prisons. Narratives, or storytelling, are not neutral accounts of the way the world works but are rather informed by social structures of power and control, necessitating subjecting them to critique and analysis. When used for social movements, this becomes especially true. In this paper, I will analyze how narratives are written/spoken and disseminated as part of the abolition or criminal justice reform movement. In organizations and movements …

A War On Resistance: Police Repression And Criminalization Of Land Defense Movements, Lydia Macy

Tapestries: Interwoven voices of local and global identities

Statement of Purpose:

In this paper, I examine the roles and functions of policing in the United States in relation to environmental justice movements and protest. Building upon analyses of the history of policing and their role in enforcing and maintaining racial capitalism, I explore how the police enable and protect the destruction of land and environments. To demonstrate the intersections of policing, racial capitalism, and environmental crises I use three case studies: the protests at Standing Rock to stop the Dakota Access Pipeline, the movement to Stop Line 3, and the movement to Stop Cop City. I found my …

Urban Farm, Not Toxic Harm: East Phillips Urban Farm And The Indigenous Right To The City, Oli Palmera Tierney

Tapestries: Interwoven voices of local and global identities

The East Phillips neighborhood in South Minneapolis has been planning to transform an abandoned warehouse into an indoor urban farm for nearly a decade. When the city of Minneapolis announced it would demolish the warehouse–releasing arsenic from the soil into the community–and use the land for a public works facility, a fierce battle over environmental justice and the right to produce space (a theory popularized by Henri Lefebvre) ensued. East Phillips is a geographically significant place: It has the largest urban concentration of Indigenous people in the country, and it is the birthplace of the American Indian Movement. Indigenous land …

Concrete Legacy: The Effects Of The Interstate Highway System On Black Communities In The U.S., Laurel M. O'Hare

Tapestries: Interwoven voices of local and global identities

This article examines the role that racism, racial capitalism, neoliberalism, and classism played in the construction of the Interstate Highway System as a part of 20th-century urban renewal. It will first understand the context of American urban renewal and then look at the policy specific to the Interstate Highway System. After that, I will discuss the resistance many communities portrayed and how bureaucracy stood firm against grassroots organizing. Then, this paper will explore the process of highway removal and new construction, as well as reparations for the communities most affected by the Interstate Highway System. Finally, I will give warnings …

Minnesotan Morals: Hmong, Somali, And Afghan Refugees And The Future Of Statewide Sanctuary Policy, Rachel Colson

Tapestries: Interwoven voices of local and global identities

Amidst animosity, tension, and discomfort over the politics and realities of immigration in the United States, Minnesota provides reprieve. The state’s attitudes towards and infrastructure for immigrant communities are distinctly positive. Despite its reputation as a safe haven, in 2021, the state legislature declined to formally adopt the label of “Sanctuary state” proposed in both houses. Sanctuary states, localities, or policies are those that refuse to follow national, often harsh, immigration law. This paper explores the rise of the Sanctuary Movement in the United States in relation to the current, politicized understanding of Sanctuary policy. Using Hmong, Somali, and Afghan …

Challenging The American Empire: A History Of Hypocrisy And Double Standards In Human Rights, Ikran J. Noor

Tapestries: Interwoven voices of local and global identities

Despite having played a significant role in the development and continuation of an international standard of human rights, the United States has a history of hypocrisy and double standards when it comes to protecting human rights both at home and abroad. This essay examines the connection between the United States and human rights in three key parts. Part I examines the concepts of manifest destiny and American exceptionalism that is prevalent in American society and how those concepts influence the United States engagement with foreign countries on human rights. Part II then, through the case studies of Israel and Afghanistan, …

Public Health Consequences Of Appellate Standards For Hostile Work Environment Claims, Lauren Krumholz

Washington Journal of Social & Environmental Justice

No abstract provided.

Forced To Bear The Burden And Now The Children: The Dobbs Decision And Environmental Justice Communities, Mia Petrucci

Washington Journal of Social & Environmental Justice

No abstract provided.

Pursuing The Exemption: The Makah's White Whale, Sarah Van Voorhis

Washington Journal of Social & Environmental Justice

No abstract provided.

Front Matter, Washington Journal Of Social & Environmental Justice

Washington Journal of Social & Environmental Justice

No abstract provided.

Filling Potholes In Pell’S Road To Reentry Success, James Monogan

Journal of Student Financial Aid

Pell eligibility for incarcerated people is a great rehabilitative opportunity, but several challenges remain. This article recaps five of the issues identified by the original research articles in this special issue. It also considers how solutions proposed in these studies may be beneficial across a variety of these issues and gathers recommendations together by which actor could implement them. Problems and solutions are corroborated by the author’s personal experience with incarceration.

Filling Critical Gaps For College In Prison Programs: Strategies From Two Community Based Organizations, Sara Alpert, Rachel Zolensky, Shon Holman-Wheatley

Journal of Student Financial Aid

When the federal government banned incarcerated students from accessing Pell Grants in the mid-1990s, a new model for supporting Higher Education in Prison (HEP) programs emerged– utilizing Community-Based Organizations (CBOs) as third-party facilitators to fill the gaps left behind in the absence of federal financial aid. With the long-awaited reinstatement of Pell for incarcerated learners that went into effect in 2023, it is essential to consider the critical role that CBOs have played in supporting college programming in the absence of Pell and how they can continue to be leveraged to ensure quality and access for Prison Education Programs (PEPs) …

The Unrealized Promise Of College-In-Prison: Financial Hurdles To Reenrollment And Completion In The Era Of Pell Reinstatement, Julia Bowling, Pavithra Nagarajan, Kristen Parsons, Neal A. Palmer

Journal of Student Financial Aid

College-in-prison programs are positioned to expand substantially under the reinstatement of Pell Grant eligibility for people in prison. While this change will enable more students who have been systemically excluded from higher education to attend college, degree completion is rare during incarceration and post-release. Student perspectives can shed light on both the value of college-in-prison and the financial barriers to realizing its value. This study analyzes data from 12 focus groups with 105 total college-in-prison student participants, 114 student survey responses, and 45 stakeholder interviews. The data were collected between 2018-2022 during a process evaluation of the College-in-Prison Reentry Initiative, …

“I Don’T Even Know What That Is”: Deprivation, Censorship, And Responsibility In Administering The Pell Grant In Prison, Erin L. Castro, Cydney Y. Caradonna, Mary R. Gould

Journal of Student Financial Aid

The violence of incarceration creates greater responsibility for higher education administrators in supporting students who are in prison. Using focus group data with incarcerated students and formerly incarcerated alumni who participated in or are actively participating in Second Chance Pell, we explore their perceptions and understandings of the Pell Grant and eligibility for the Pell Grant, including lifetime eligibility used limits. Through a lens of Witnessing, we argue that deprivation and censorship of information negatively influence students’ access to accurate and timely information about federal student aid and their ability to fully participate in the process. Accordingly, college and university …

The Effects Of Citrulline Malate On Multiple Bout, High-Intensity Aerobic Exercise: A Pilot Study, Macy Kate Bynum, Annika Marie Pschorr, Taylor Carrico, Morgan Maleske, Matthew Hermes, Brenda Reeves

Steeplechase: An ORCA Student Journal

Citrulline malate (CM) is suggested to improve performance and post-exercise recovery. There is limited research on the effect of CM on short duration, high-intensity aerobic exercise with ambiguous results. The effects of acute CM supplementation on combined aerobic/anaerobic performance in novice CrossFit® participants is unknown. PURPOSE: To examine the effects of acute CM vs. placebo (PL) supplementation on multiple-bout, high- intensity aerobic performance in novice Nancy CrossFit® participants. METHODS: Eight recreationally trained males (X±SD; age = 20.8 ± 2.7 yrs, height = 180.0 ± 6.1 cm, body fat 6.9 ± 2.3%, VO2max = 52.2 ± 4.8 ml/kg/min, 1RM squat = …

Lessons Learned: Til Schuermann, Mercedes Cardona

Journal of Financial Crises

Til Schuermann joined the Federal Reserve Bank of New York (FRBNY) in 2001 and held several positions during his tenure, including senior vice president and head of Financial Intermediation in Research and head of Credit Risk in Bank Supervision. In spring 2009, he played a leadership role in the design and execution of the “bank stress test” and the subsequent Comprehensive Capital Analysis and Review (CCAR) programs. After leaving the FRBNY in March 2011, he became a partner at management consulting firm Oliver Wyman, where he has led stress testing for more than 25 banks and financial institutions. He participated …

Lessons Learned: Ádám Banai, Matthew A. Lieber

Journal of Financial Crises

During the Global Financial Crisis (GFC), Ádám Banai served first as an analyst in the National Bank of Hungary (Magyar Nemzeti Bank, or MNB), where he helped the bank develop and implement a macroprudential framework for financial stability. Since 2020, he has served as MNB’s executive director of monetary policy instruments, financial stability, and foreign reserve management. This Lessons Learned is based on an interview with Banai conducted on April 18, 2023.

Portugal: Banco Espírito Santo Restructuring, 2014, Salil Gupta

Journal of Financial Crises

Banco Espírito Santo (BES) was the second-largest private bank in Portugal in 2014, with assets of EUR 80 billion (USD 81 billion). A capital increase of EUR 1.1 billion to the BES was concluded on market terms in June 2014. In July 2014, BES breached minimum capital requirements and reported a EUR 3.6 billion loss owing to improper loans made to the nonfinancial arm of the Espírito Santo (ES) group. The Bank of Portugal (BOP) adopted a resolution measure for BES on August 3, 2014, to safeguard financial stability by protecting all depositors and ensuring continuation of operating activities of …