Digital Commons Network^™

Non-Thermal Plasma Reduces Hsv-1 Infection Of And Replication In Hacat Keratinocytes In Vitro, Julia Sutter, Jascha Brettschneider, Brian Wigdahl, Peter Bruggeman, Fred Krebs, Vandana Miller

Kimmel Cancer Center Faculty Papers

Herpes simplex virus type 1 (HSV-1) is a lifelong pathogen characterized by asymptomatic latent infection in the trigeminal ganglia (TG), with periodic outbreaks of cold sores caused by virus reactivation in the TG and subsequent replication in the oral mucosa. While antiviral therapies can provide relief from cold sores, they are unable to eliminate HSV-1. We provide experimental results that highlight non-thermal plasma (NTP) as a new alternative therapy for HSV-1 infection that would resolve cold sores faster and reduce the establishment of latent infection in the TG. Additionally, this study is the first to explore the use of NTP …

Blocking The Dimerization Of Polyglutamine-Expanded Androgen Receptor Protects Cells From Dht-Induced Toxicity By Increasing Ar Turnover, Allison Lisberg, Yuhong Liu, Diane E. Merry

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular degenerative disease caused by a polyglutamine expansion in the androgen receptor (AR). This mutation causes AR to misfold and aggregate, contributing to toxicity in and degeneration of motor neurons and skeletal muscle. There is currently no effective treatment or cure for this disease. The role of an interdomain interaction between the amino- and carboxyl-termini of AR, termed the N/C interaction, has been previously identified as a component of androgen receptor-induced toxicity in cell and mouse models of SBMA. However, the mechanism by which this interaction contributes to disease pathology is unclear. …

Pedigree Analysis Of Congenital Stationary Night Blindness And Surveillance Of Related Problems In The Area Of Depalpur, Okara-Pakistan, Muhammad Abdullah, Muhammad Sajjad Sarwar, Muhammad Rizwan, Muhammad Iqbal Usama, Hamza Zulfiqar, Muhammad Wajid, Saira Ashfaq

Journal of Bioresource Management

Congenital stationary night blindness (CSNB) is described as a set of inherited, non-progressive retinal conditions in which the rod pathway is primarily affected, resulting in difficulty adapting to low-light situations due to impaired photoreceptor transmission. Objectives of study was to identify patients with CSNB and explore their lifestyle and the impact of CSNB on their daily routines in selected areas. Total seven families having CSNB, belonging to five villages (Abadi Haji Ismaeel, Sunari wala, Tibba, Shamdin, and Chorasta Mian Khan) of Depalpur, district Okara, were investigated in March 2023. The CSNB prevalence was calculated as 2.528 % in all selected …

Wedge Shaped Decompression To Remove Ear Cartilage For A Patient With An Ear Intradermal Nevi, Qi-Chao Jian, Xi-Dan Xu, Meng-Yao Hu, Chen Zheng

Faculty, Staff and Student Publications

No abstract provided.

March 29, 2024 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

No abstract provided.

Increasing Folic Acid Self-Efficacy In College-Age Women Of Childbearing Age, Kristie Buchanan

Dissertations

Preventative measures taken by women of childbearing age before and during conception limit the risk of fetal defects or complications. One specific measure that is recommended by the Centers for Disease Control and Prevention is that all women of childbearing age take folic acid 400 mcg daily. Evidence-based research suggests that taking 400 mcg daily limits the risk of fetal neural tube defects if taken daily and started at least two months before conception. Fetal neural tube defects are classified as defects that damage the baby's spine and brain. The researcher conducted an evidence-based practice project that sought to determine …

Blending Behavioural Theory And Narrative Analysis To Explore The Lived Experience Of Obesity And Assess Potential Engagement In A Uk Weight Management Service: Theory And Narrative Approaches In Weight Management, Jessica Gillespie, Hannah Wright, Jonathan Pinkney, Helen Lloyd

School of Psychology

Background: Current treatments for people with obesity emphasise the need for person-centred approaches that consider complex biopsychosocial factors and value the lived experience of people when attempting to lose weight. Methods: Narrative interviews (n = 20) were conducted with people living with obesity to explore the causes of their weight gain and their expectations and engagement with treatment at a Weight Management Clinic. A mixed inductive and deductive qualitative analysis identified utterances that represented psychological constructs used to understand self-appraisal and health behaviour. A narrative analysis was used to situate these findings in the context of a participant’s life story. …

Effects Of Lexia Reading Core5 On Non-Ell Upper Elementary Students’ Reading Comprehension, Jane Jordan Carroll

Walden Dissertations and Doctoral Studies

No abstract provided.

Elementary Mathematics Teachers’ Perceptions Of Rti2 Implementation For Special Education Students In Southwest Tennessee, Dennis Lee Kimbrough

Walden Dissertations and Doctoral Studies

No abstract provided.

Deploying The Hybrid Project Management Methodology Framework In Major Transportation Projects In The United Kingdom, Ana C González Leyba, Muhammad Qasim Rana, Anabel Milagros Salazar, Mandeep Saini, Olugbenga Oladinrin, Angela Lee

School of Art, Design and Architecture

This paper introduces a proposed Hybrid Project Management Methodology Framework, tailored for Project Managers engaged in overseeing large-scale road transport projects in the United Kingdom. Through a mixedmethod approach comprising of a comprehensive literature review, a structured quantitative questionnaire administered to industry professionals, and a case study examining the application of Lean and Agile methodologies in a complex megaproject, this study identifies the prevailing project management methodologies in use within the UK Mega Transport Projects (MTP) domain. The surveyed professionals, primarily experienced project managers in construction, provided insights into the challenges encountered in MTP, helping to rank the most common …

Exploring The Underlying Barriers For The Successful Transition For Women From Higher Education To Employment In Egypt: A Focus Group Study, Muhammad Qasim Rana, Shadia Fahim, Mohammed Saad, Angela Lee, Olugbenga Timo Oladinrin, Lekan Damilola Ojo

School of Art, Design and Architecture

Education is the foundation of culture and the engine of economies; it is an essential part of life. However, it remains inaccessible or unavailable in some parts of developing nations. Moreover, such barriers for girls and women can extend beyond education and into the workplace, and this is a bone of contention based on erroneous beliefs and other factors. Barriers for girls’ and women’s education are debatable in the literature; however, there is a sparsity of literature that focuses on the bridge to the workplace. Therefore, through a focus group study, this study explores the barriers that prohibit the transition …

Residential Metals Abatement Program Construction Completion Report (Non- Residential Parcels – Indoor Dust) East Middle School, Christopher Berg, Thomas J. Beckman

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Stereotyped Non-Stereotypicality: Exploring Positive Effects Of Non-Stereotypical Gender Portrayals On Consumer Perceptions, Veronika Ponomarenko

USF Tampa Graduate Theses and Dissertations

This research attempts to identify contexts where non-stereotypical gender portrayals may have positive effects on consumer perceptions. It tests the perceived self-expressiveness of non-stereotypical gender portrayals as the mediating mechanism behind these effects as well as other alternative mechanisms in a comprehensive experiment. The analysis results show that an interpretation of gender through the theoretical lens of extravagance rather than self-expressiveness seems to be more appropriate. This study also introduces an overarching theoretical framework of metacognitive experiences that may explain the processes driving the effects of non-stereotypical gender portrayals on consumer perceptions. Finally, this research explores different types of gender …

Hidden Monstrosities: The Transformation Of Medieval Characters And Conventions In Shakespeare's Romances, Lynette Kristine Kuliyeva

USF Tampa Graduate Theses and Dissertations

When Shakespeare’s First Folio was published in 1623, it was entitled Mr. William Shakespeare’s Comedies, Histories, and Tragedies, the title designating the three genres under which his plays would be categorized for the next 250 years. Later, Irish critic Edward Dowden took it upon himself to restructure the Shakespearean canon by adding plays that were not previously published in the First Folio, reclassifying the genres of several of the plays, and establishing a new genre to accompany the previous three: romance. Within this fourth generic category of romance, Dowden situated four of the Shakespearean plays: Pericles, Prince of Tyre; Cymbeline; …

Spatial Patterns Of Building Damages And Associated Socio-Economic Factors By Hurricane Ian, Md Zakaria Salim

USF Tampa Graduate Theses and Dissertations

Literature shows that communities with different socio-economic conditions suffer from different levels of damage in disasters. In addition to the physical intensity of hazards, such disparities are also related to varying abilities to prepare for and respond to natural hazards. The study analyzes the spatial patterns of building damage in Hurricane Ian in 2022 and investigates the socio-economic disparities related to building damage. Specifically, this study employs NASA’s Damage Proxy Map (DPM2) to analyze Ian's spatial patterns of building damage. Then, it uses statistical analysis to assess the relationship between building damage and various physical and socio-economic variables at building …

Atrial Fibrillation Symptom Reduction And Improved Quality Of Life Following The Hybrid Convergent Procedure: A Converge Trial Subanalysis., Jaswinder Gill, Karl J Crossen, Christopher Blauth, Faraz Kerendi, Saumil R Oza, Anthony R Magnano, Mark A Mostovych, Michael E Halkos, David Tschopp, Jose Osorio, Paul Tabereaux, William Boedefeld, Kenneth Civello, Syed Ahsan, John Yap, Sreedhar Billakanty, Steve Duff, Otto Costantini, Eric Espinal, Andy Kiser, Christian Shults, David Pederson, James Garrison, David M Gilligan, Michael G Link, Marcin Kowalski, Christopher Stees, Jason S Sperling, Israel Jacobowitz, Felix Yang, Yisachar J Greenberg, David B De Lurgio

Heart and Vascular Articles

BACKGROUND: CONVERGE was a prospective, multicenter, randomized controlled trial that evaluated the safety of Hybrid Atrial Fibrillation Convergent (HC) and compared its effectiveness to endocardial catheter ablation (CA) for the treatment of persistent atrial fibrillation (PersAF) and longstanding PersAF (LSPAF). In 2020, we reported that CONVERGE met its primary safety and effectiveness endpoints. The primary objective of the present study is to report CONVERGE trial results for quality of life (QOL) and Class I/III anti-arrhythmic drug (AAD) utilization following HC.

METHODS: Eligible patients had drug-refractory symptomatic PersAF or LSPAF and a left atrium diameter ≤6.0 cm. Enrolled patients were randomized …

Providing Community Protection From Sex Offenders – At What Cost?, Jessica Novick

Cardozo International & Comparative Law Review (CICLR) Blog

With the release of The Ken and Barbie Killers: The Lost Murder Tapes mini-series documentary on HBO’s Max recently, a renewed focus can be put on the “dangerous offender” status that murderer and serial rapist Paul Bernardo has who is one of the two central figures of the docuseries. Sexual offenders are some of the most feared types of criminals in our current society. Law & Order: SVU just began airing its 25th season, and the enduring legacy of this show and others similar to it has enriched the cultural fear of sex offenders. Now is an important time culturally …

Preferences And Willingness To Pay For A Novel Carbon Label: A Choice Experiment In The United States, Wen Lin, Rudolfo M. Nayga Jr, Wei Yang

Agricultural Economics and Agribusiness Faculty Publications and Presentations

This study investigates how US consumers respond to and value a new technology-based carbon label on food products. Results indicate that individual valuation of the carbon-labeled bread is $4/20 oz, marginally lower than the valuation of the conventional and organic bread products. Moreover, individuals belonging to certain market segments, such as non-White, liberal, and well-educated consumers, and those having a high level of knowledge about the causes of climate change, exhibit a higher valuation for the novel carbon label.

Extensions Of Vectors In Partitioning: Analysis Of Clustering For Grouped Data, Allison Plaxco

Electronic Theses and Dissertations Archive

Cluster analysis is a popular, well-utilized unsupervised machine learning technique to group individual subjects based on the similarity of their traits. In epidemiological and biomedical research, clustering individuals into groups in order to study their group patterns with respect to outcomes of interest is often useful. Popular clustering methods, including the k-means framework, are well suited to cluster individuals based on continuous, nominal, and mixed type variables. Gower’s similarity is an additional option for clustering based on mixed type data. Clustering of data that has an inherently nested structure poses unique challenges to the classic clustering methodologies, as these solutions …

Faster Detection Of Asymptomatic Covid-19 Cases Among Care Home Staff In England Through The Combination Of Sars-Cov-2 Testing Technologies, Finola Ryan, Joanna Cole-Hamilton, Niharika Dandamudi, Matthias E Futschik, Alexander Needham, Rida Saquib, Raghavendran Kulasegaran-Shylini, Edward Blandford, Michael Kidd, Éamonn O'Moore, Ian Hall, Malur Sudhanva, Paul Klapper, Andrew Dodgson, Adam Moore, Madeleine Duke, Sarah Tunkel, Chris Kenny, Tom Fowler

School of Biomedical Sciences

To detect SARS-CoV-2 amongst asymptomatic care home staff in England, a dual-technology weekly testing regime was introduced on 23 December 2020. A lateral flow device (LFD) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) test were taken on the same day (day 0) and a midweek LFD test was taken three to four days later. We evaluated the effectiveness of using dual-technology to detect SARS-CoV-2 between December 2020 to April 2021. Viral concentrations derived from qRT-PCR were used to determine the probable stage of infection and likely level of infectiousness. Day 0 PCR detected 1,493 cases of COVID-19, of which …

Repository And Haul Route Geotechnical Pre-Design Investigation (Pdi) Work Plan, Jacobs Engineering Group

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Repository And Proposed Haul Route – Silver Bow Creek Conservation Area Quality Assurance Project Plan, Jacobs Engineering Group

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

End-Of-Life Cohorts From The Dartmouth Institute: Risk Adjustment Across Health Care Markets, The Relative Efficiency Of Chronic Illness Utilization, And Patient Experiences Near The End Of Life, Kristen K. Bronner, David C. Goodman

Dartmouth Scholarship

Since their inception, small area studies intended to measure health system performance have been challenged by concerns that regional variation in health care may be primarily explained by differences in patient health risk. Controlling for regional population differences depends on appropriate risk adjustment, but the adequacy of the methods used in early analyses was contested. A novel response to these concerns was the development of end-of-life cohorts by Dartmouth Atlas investigators. These were used initially to control for differences in population health status in studies investigating relative efficiency across regions. Later, they became useful for studying hospital-level variation in chronic …

Comments For The Butte Priority Soils (Bpsou) Residential Metals Abatement Program (Rmap) – Interior School Dust – Investigation Summary Report – Gold Hill Lutheran (Dated February 5, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Diamond's Hidden Gems - Kram For The Exam, Diamond R. Williams

Libraries' Documents

Taking your course finals is a necessary part of your academic journey, and preparing for them is a vital step. This includes more than just reviewing your notes and memorizing information. Preparing includes ensuring that you are mentally, emotionally, and physically sound enough to withstand long exam periods and apply the knowledge you have spent the semester collecting.

The UCF Student Government (SG) hosts events intended to help you with this process!

‘In This Prison We Have Our Main Meal At 11:30 Am’. The Significance Of ‘Time’ For Food Among People Serving Custodial Sentences In England And Wales, Julie M. Parsons

School of Law, Humanities and Social Sciences

In this article, I am thinking through the social life of time for food in prison from a practice theory perspective. I draw upon empirical data from in-depth qualitative interviews with people serving custodial sentences or recently released from prison in England and Wales who have been on placement at a prisoner resettlement charity (RC). These support findings from Her Majesty’s Inspectorate for Prisons report on Life Inside: Food from 2016, and I consider two aspects from the report, (i) an exploration of the standards and conditions in which food is consumed and (ii) the timings of mealtimes. For people …

Structure Of Alpha-Synuclein Fibrils Derived From Human Lewy Body Dementia Tissue, Dhruva D Dhavale, Katherine Basore, Isabelle R Gordon, Jialu Liu, Jennifer Y O'Shea, Michael J Rau, Zachary Smith, Brock Summers, Richard J Perrin, Joel S Perlmutter, James A J Fitzpatrick, Paul T Kotzbauer, Et Al.

2020-Current year OA Pubs

The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. Here we develop and validate a method to amplify Asyn fibrils extracted from LBD postmortem tissue samples and use solid state nuclear magnetic resonance (SSNMR) studies to determine atomic resolution structure. Amplified LBD Asyn fibrils comprise a mixture of single protofilament and two protofilament fibrils with very low twist. The protofilament fold is highly similar to the fold determined by a recent cryo-electron microscopy study for a minority population of twisted single protofilament fibrils extracted …

Female Leaders’ Lived Experience Of Transitioning To Leaders Of Knowledge Workers In A Hybrid Workplace Model, Jennifer Amy Ladouceur

Walden Dissertations and Doctoral Studies

No abstract provided.

Challenges And Considerations Of Preclinical Development For Ipsc-Based Myogenic Cell Therapy, Congshan Sun, Carlo Serra, Brianna Harley Kalicharan, Jeffrey Harding, Mahendra Rao

Faculty, Staff and Students Publications

Cell therapies derived from induced pluripotent stem cells (iPSCs) offer a promising avenue in the field of regenerative medicine due to iPSCs' expandability, immune compatibility, and pluripotent potential. An increasing number of preclinical and clinical trials have been carried out, exploring the application of iPSC-based therapies for challenging diseases, such as muscular dystrophies. The unique syncytial nature of skeletal muscle allows stem/progenitor cells to integrate, forming new myonuclei and restoring the expression of genes affected by myopathies. This characteristic makes genome-editing techniques especially attractive in these therapies. With genetic modification and iPSC lineage specification methodologies, immune-compatible healthy iPSC-derived muscle cells …

Arch: Improving The Performance Of Clonal Hematopoiesis Variant Calling And Interpretation, Irenaeus C C Chan, Alex Panchot, Evelyn Schmidt, Brian J Wiley, Jie Liu, Kimberly Turner, Duc Tran, J Scott Beeler, Armel Landry Batchi-Bouyou, Daniel C Link, Kelly L Bolton, Et Al.

2020-Current year OA Pubs

MOTIVATION: The acquisition of somatic mutations in hematopoietic stem and progenitor stem cells with resultant clonal expansion, termed clonal hematopoiesis (CH), is associated with increased risk of hematologic malignancies and other adverse outcomes. CH is generally present at low allelic fractions, but clonal expansion and acquisition of additional mutations leads to hematologic cancers in a small proportion of individuals. With high depth and high sensitivity sequencing, CH can be detected in most adults and its clonal trajectory mapped over time. However, accurate CH variant calling is challenging due to the difficulty in distinguishing low frequency CH mutations from sequencing artifacts. …