Digital Commons Network^™

Mitochondrial Etf Insufficiency Drives Neoplastic Growth By Selectively Optimizing Cancer Bioenergetics, David Papadopoli, Sergej Djuranovic, Et Al.

2020-Current year OA Pubs

Mitochondrial electron transport flavoprotein (ETF) insufficiency causes metabolic diseases known as a multiple acyl-CoA dehydrogenase deficiency (MADD). In contrast to muscle, ETFDH is a non-essential gene in acute lymphoblastic leukemia NALM6 cells, and its expression is reduced across human cancers. In various human cancer cell lines and mouse models, ETF insufficiency caused by decreased ETFDH expression limits flexibility of OXPHOS fuel utilisation but paradoxically increases bioenergetics and accelerates neoplastic growth via activation of the mTORC1/BCL-6/4E-BP1 axis. Collectively, these findings reveal that while ETF insufficiency is rare and has detrimental effects in non-malignant tissues, it is common in neoplasia, where ETFDH …

Learning Across Disciplines: A Team-Based Approach To Ce, Carissa Blumenshine, Heather Raeder

Nursing

No abstract provided.

Loneliness Among Growing Adolescents: How The Bible Is The Sufficient Example For Every Aspect Of Forming Community, Savannah Paige Clemons

Senior Honors Theses

Adolescents in the world today have a variety of opportunities to take part in, as they are more digitally connected with people than ever before. In American culture there is a recognizable goal to stay at a constant pace of achieving more and more; however, technology no longer acts as an aid, but it has become a replacement to physical community. This isolation and lack of living life with community is causing a detriment to adolescents’ mental health. The Bible is sufficient for every aspect of community through showing structure of belonging and relationship.

Sustainability In The Fashion Industry: Environmental Effects & Analyzing Innovative Approaches To Reducing Environmental Impact While Maintaining Profitability And Effectiveness, Haley Castillo Rebollar

Senior Honors Theses

The fast-fashion business model has several severe environmental impacts, including resource overconsumption, chemical pollution, greenhouse gas emissions, and solid waste consumption. Hence, the sustainable fashion alternative is questioned as to whether it can be applied with recoverable economic value and limited consequential impact when considering novel approaches in business model innovation, supply chain transformation, and the adoption of digital technologies. Evidence suggests that sustainability and profitability need not be mutually exclusive when strategic intervening actions are effectively managed. The set of principles of the circular economy, sustainable enterprise architecture frameworks, green supply chain management, advanced systems of forecasting, and three-dimensional …

Behavioral Biases In Investment Decision-Making: Evidence From Short-Term Trading Behavior During High-Volatility Market Events, Jayden A. Shwed

Honors Theses

This study examines how behavioral biases influence short-term trading behavior during periods of high market volatility. While traditional financial theory assumes that investors act rationally, real-world market behavior often reflects the influence of psychological factors. Rather than treating behavioral bias as a single market force, this thesis compares how different biases appear across distinct market environments. Using an empirical, case-study-based approach, this study evaluates three recent market episodes: the COVID-19 market crash in 2020, the GameStop meme stock surge in 2021, and the rise of NVIDIA during the artificial intelligence boom from 2023 to 2024. Historical price and trading volume …

The Mystery Of The Epstein-Barr Virus: How To Detect An Undetectable Virus, Paris Lange

Honors Theses

The Epstein-Barr Virus (EBV) is a latent virus that stays in the body after the initial acute infection. In severe cases, this virus can lead to viral myocarditis and can cause life-threatening health issues. One reason this virus is impactful is its ability to suppress the intrinsic apoptotic response through a gene called BHRF1. This gene is an early lytic gene that encodes a homolog of a human pro-survival protein named Bcl-2. This allows the gene to act as an anti-apoptotic survival factor, facilitating the viral persistence inside the host without premature death of the host’s cells. Here, the BHRF1 …

Granite Staters See Social Media As Harmful To Society But Most Still Use It At Least Occasionally 5/5/2026, Unh Survey Center

All UNH Survey Center Polls

Social media users in New Hampshire on average report using social media platforms nearly 17 hours per week, with YouTube and Facebook being the most popular. A majority say their social media usage has stayed about the same over the past 12 months but just over half want to use social media less often. About a third of users in the state believe social media has a negative effect on their mental health and overall life, particularly those under the age of 35, women, and those with a college degree or more education. Granite Staters overall are quite critical in …

Massachusetts Users Split On Personal Impact Of Social Media But Most See Negative Effect For Society 5/5/2026, Unh Survey Center

All UNH Survey Center Polls

Social media users in Massachusetts report using social media platforms just over 18 hours per week and nearly half want to use social media less often. YouTube is the most commonly used platform, though the small number who use Snapchat and Discord report using it quite frequently. Democrats and those under the age of 35 report being the most prolific users of social media. Three in eight users in the state believe social media has a negative effect on their mental health, but a plurality of the heaviest social media users say it improves their mental health. Bay Staters are …

More Than A Quarter Of Social Media Users In Rhode Island Feel Addicted, Most Young Users Want To Use It Less 5/5/2026, Unh Survey Center

All UNH Survey Center Polls

Social media users in Rhode Island report using social media platforms nearly 22 hours per week. More than half of social media users want to use it less, particularly those under 50, and more than a quarter feel addicted to social media. YouTube, Facebook, and Instagram are used by the most Rhode Islanders, but the fifth of state residents who use TikTok report using it most frequently. Heavy users of social media report higher feelings of anxiety, depression, and stress. Most Rhode Islanders believe social media has a negative effect on productivity, mental health, and on society in general, and …

The Prospector, May 5, 2026, Utep Student Publications

The Prospector

No abstract provided.

Bioinformatic Resolution Of Candidate Stress-Response Homologs In Cryptosporidium Parvum: P53-Family Vs Sestrin Identity, Freeman Tobechukwu Ezeala Mr.

Biochemistry and Molecular Biology

Cryptosporidium parvum is an apicomplexan protozoan of major public-health importance, but accurate genome annotation in this organism remains difficult because of its compact genome, deep protein divergence, and the presence of compositionally biased or low-complexity regions that can mislead similarity-based analysis.

In this thesis, I examined one such annotation problem involving a conserved Cryptosporidium stress-response candidate protein, CPATCC_0028580_t1 (833 aa). The central question was whether this protein is better interpreted as a member of the p53 family, based on similarity to p53-like DNA-binding domains (PF00870), or as a member of the Sestrin family associated with the PA26 domain.

I explored …

Substantive Biases? Analyzing Ideological Bias In Substantive Due Process Claims On The Roberts Court, Nicholas J. Ginsberg

Undergraduate Honors Theses

This thesis examines whether judicial ideology has a stronger influence on Supreme Court decision making in substantive due process claims when compared to other areas of law through the Roberts Court. Previous scholarship has noted that ideology is a factor in judicial decision making, however, there is little scholarship on if specific areas of law makes ideology play a larger factor in decision making. Utilizing justice-level voting records from the Roberts Court and Segal-Cover scores to measure judicial ideology, a logistic regression model is utilized to analyze the relationship between ideology and voting behavior in substantive due process cases and …

Comparing Llm Architectures In Street Fighter Iii, Andrew Hinh, Hyemin Doo, Jack Wu

Computer Science and Engineering Senior Theses

We built a browser-based Street Fighter III benchmark for comparing large language models (LLMs) and visionlanguage models (VLMs) under real-time constraints. The game runs through a Gymnasium-like control loop that exposes both frames and structured state while the agent emits button actions. We deploy the system on Modal and stream matches overWebRTC, which lets us compare ability, latency, and cost in one setting instead of spreading them across unrelated benchmarks. Because the benchmark is narrow, architectural tradeoffs that are easy to blur in offline evaluation show up quickly during live play.

Multi-Scale Data Improves Performance Of Machine Learning Model For Long Covid Identification, Christopher Guardo, Zhang Xinmeng, Srushti Gangireddy, Yan Chao, V Eric Kerchberger, Alyson L Dickson, Emily R Pfaff, Hiral Master, Xin Yi, Melissa Basford, Christopher G Chute, Nguyen K Tran, Salvatore Mancuso, Toufeeq Ahmed Syed, Zhao Zhongming, Feng Qiping, Melissa Haendel, Christopher Lunt, Paul A Harris, Li Lang, Geoffrey S Ginsburg, Joshua C Denny, Dan M Roden, Wei Wei-Qi

Faculty, Staff and Student Publications

Background: Long COVID affects a substantial proportion of the over 778 million individuals infected with SARS-CoV-2, yet predictive models remain limited in scope. While existing efforts, such as the National COVID Cohort Collaborative (N3C), have leveraged electronic health record (EHR) data for risk prediction and identification, accumulating evidence points to additional contributions from social, behavioral, and genetic factors.

Methods: Using a diverse cohort of SARS-CoV-2-infected individuals (n > 17,200) from the NIH All of Us Research Program, we investigated whether integrating EHR data with survey-based and genomic information improves model performance.

Results: Our multi-scale approach outperforms EHR-only model's area under the …

Large-Scale Genetic Characterization Of Parkinson’S Disease In The African And African Admixed Populations, Fulya Akçimen, Kimberly Paquette, Peter Wild Crea, Kathryn Step, Emily Waldo, Mathew J Koretsky, Paula Saffie-Awad, Charles Achoru, Funmilola Taiwo, Simon Ozomma, Gerald Onwuegbuzie, Marzieh Khani, Spencer Grant, Lukman Owolabi, Chiamaka Okereke, Olajumoke Oshinaike, Emmanuel Iwuozo, Suleyman Can Akerman, Paul Suhwan Lee, Shyngle Oyakhire, Nosakhare Osemwegie, Kensuke Daida, Sani Abubakar, Adedunni Olusanya, Mariam Isayan, Christiane Alvarez, Rami Traurig, Adebimpe Ogunmodede, Sarah Samuel, Mary B Makarious, Fadimatu Sa'ad, Rashidat Olanigan, Kristin Levine, Ewere Marie Ogbimi, Dan Vitale, Francis Odiase, Francis Ojini, Olanike Odeniyi, Zih-Hua Fang, Nkechi Obianozie, Deborah A Hall, Ernest Nwazor, Tao Xie, Francesca Nwaokorie, Mahesh Padmanaban, Paul Nwani, Ejaz A Shamim, Alero Nnama, David Standaert, Morenikeji Komolafe, Marissa Dean, Godwin Osaigbovo, Elizabeth Disbrow, Ismaila Ishola, Ashley Rawls, Frank Imarhiagbe, Shivika Chandra, Cyril Erameh, Vanessa Hinson, Naomi Louie, Ahmed Idowu, J Solle, Scott A Norris, Abdullahi Ibrahim, Camilla Kilbane, Gauthaman Sukumar, Lisa M Shulman, Daniel Ezuduemoih, Julia Staisch, Sarah Breaux, Clifton Dalgard, Erin R Foster, Abiodun Bello, Andrew Ameri, Raquel Real, Erica Ikwenu, Huw R Morris, Roosevelt Anyanwu, Erin Furr Stimming, Kimberley Billingsley, Wemimo Alaofin, Pilar Alvarez Jerez, Osigwe Agabi, Dena G Hernandez, Rufus Akinyemi, Sampath Arepalli, Laksh Malik, Raymond Owolabi, Yakub Nyandaiti, Hampton L Leonard, Kolawole Wahab, Oladunni Abiodun, Carlos F Hernandez, Fatima Abdulai, Hirotaka Iwaki, Soraya Bardien, Christine Klein, John Hardy, Henry Houlden, Kamalini Ghosh Galvelis, Mike A Nalls, Nabila Dahodwala, Whitley Aamodt, Emily Hill, Alberto Espay, Stewart Factor, Chantale Branson, Cornelis Blauwendraat, Andrew B Singleton, Oluwadamilola Ojo, Lana M Chahine, Njideka Okubadejo, Sara Bandres-Ciga

Faculty, Staff and Student Publications

Elucidating the genetic contributions to Parkinson's disease aetiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization of potentially disease-causing, protein-altering and splicing mutations in 710 cases and 11 827 controls from genetically predicted African or African admixed ancestries. We explored copy number variants (CNVs) and runs of homozygosity in prioritized early onset and familial cases. Our study identified rare GBA1 coding variants to be the most frequent mutations among patients with Parkinson's disease, with a frequency of 4% in our case cohort. Of the 18 …

Trends In Trauma: Increasing Rates Of Sexual And Domestic Violence Among Female Latin American Asylum Seekers, Alfonso Mercado, Andy U. Torres, Francisco Banda, Amanda Venta, Luz M. Garcini, Alejandro Luis Vázquez, Aldo Barrita, Oswaldo Moreno

Psychological Science Faculty Publications

The last 10 years of scientific research analyzing asylum-seekers’ mental health has established high rates of trauma exposure throughout the migratory trajectory. However, limited studies have identified gender-based violence among Central American asylum-seeking women. The purpose of this study was to identify the frequencies of gendered-base violence among asylum-seeking women from Central and South America at a humanitarian respite center (USA) and a tent encampment (Mexico) on both sides of the United States–Mexico Border using data from three independent studies in 2016, 2019, and 2023, respectively. Visual trend analysis identified a peak in domestic violence in 2019, a stable frequency …

Analysis Of Dynamic Difficulty Scaling Ai In Video Games, Tyrese W. Walker

Honors Program: Senior Projects (Public)

Video games are a popular form of interactive media and, since their inception, have become one of the largest forms of media consumed. As such, they have evolved greatly from their humble beginnings into much more complex experiences, and adjusting the difficulty level to suit the needs of the player has become common practice. While there are simple ways to do so, the best games often feature a dynamic difficulty-scaling system that adapts to the player. Classics like Resident Evil and Left 4 Dead are excellent examples of innovative dynamic scaling design. By analyzing the strongest elements of these works, …

Practicing A Pedagogy Of Slow Resistance In The Writing Classroom, Kathleen Rose Dillon

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Especially during and following the ‘lockdown era’ of the COVID-19 pandemic, college writing instructors have sought ways to mitigate the harms of neoliberal and capitalist practices in the academy and writing classroom. Incorporating elements of Slow Pedagogy, Disability Studies, Anti-Capitalist Composition, and Participatory Action Research methodology, this dissertation argues for practicing a Pedagogy of Slow Resistance, centering co-creation and relationship-building, to resist neoliberal and capitalist values, and promote student belonging and well-being. This dissertation highlights a classroom study in which two undergraduate students in the TRIO program, which serves students who are first in their family to go to college, …

Spartan Daily, May 5, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 41

Connecticut Residents Report Higher Social Media Use Than Neighbors, Most Say Social Media Negative For Society 5/5/2026, Unh Survey Center

All UNH Survey Center Polls

Social media users in Connecticut report using social media platforms just over 24 hours per week, higher than residents of Rhode Island, Massachusetts, and New Hampshire. More than half of social media users want to use it less, particularly those under 50, and a quarter feel addicted to social media. YouTube, Facebook, and Instagram are the most popular platforms among Connecticut residents, with YouTube used most frequently. Connecticut residents generally believe social media has a somewhat positive effect on creativity, but most feel it has a negative effect on productivity, mental health, and on society in general, and bipartisan majorities …

Improving Nursing Orientation: A Preceptor-Led Competency Program, Brandy Tanesa Broadway

Walden Dissertations and Doctoral Studies

No abstract provided.

Consumer Evaluations Of Corporate Generosity, Yanyi Leng

Olin Business School Graduate Student Theses and Dissertations

How do consumers evaluate corporate generosity? This dissertation examines how both the structure and communication of firms’ charitable initiatives shape consumer judgments, revealing that consumers are highly sensitive to cues about consistency, authenticity, and responsibility embedded in corporate social responsibility (CSR) efforts. In Chapter One, “Consumers Prefer that Corporations Donate Periodically,” I examine how the temporal consistency of corporate giving influences consumer evaluations. Across seven preregistered studies (N = 150,563), including two large-scale field studies and five online experiments, I demonstrate that making a series of periodic contributions, e.g., donating $20,000 per month for 12 months, rather than donating an …

Essays In Household And International Finance, Tatiana Vdovina

Olin Business School Graduate Student Theses and Dissertations

In my first essay, I study whether U.S.-Mexico dual residents borrow in pesos or dollars, using both theory and survey data. I attempt to understand the microeconomic and behavioral foundations of the actual and theory-predicted currency choice by households. I also attempt to reconcile the export- and import-related theory of currency choice proposed in the corporate finance literature with behavioral tests. Finally, I test the nominal uncovered interest parity condition established in McBrady & Schill [1] in a household setting by analyzing if there can be any cost savings from borrowing in dollars over pesos and vice versa. Theoretically, I …

Small Partial Deletion Of A Highly Gc-Rich Foxf1 Exon 1 In Two Deceased Siblings With Alveolar Capillary Dysplasia, Hiuling Chan Joiner, Shruti A Pande, Przemyslaw Szafranski, Partha Sen, Gail Deutsch, Pawel Stankiewicz

Faculty, Staff and Students Publications

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal lung developmental disorder caused by haploinsufficiency of FOXF1. While larger-sized coding and noncoding copy-number variant (CNV) deletions involving the FOXF1 locus are detected in approximately half of histopathologically-diagnosed ACDMPV patients, small CNVs remain diagnostically challenging. Here, we revisited an unsolved case of familial ACDMPV with two affected siblings. Whole genome sequencing (WGS) of 30-year-old archival lung autopsy tissue analyzed using AI powered platform revealed a 151 bp CNV deletion involving a highly GC-rich portion of exon 1 of FOXF1 that was not detected using Sanger sequencing and …

Apathy, Effort-Based Decisions And Brain Integrity In Alzheimer’S And Parkinson’S Diseases, Lee-Anne Morris, Hideo Suzuki, Seonjoo Lee, Zekai Jin, Bryan B Chen, Ana Marin, Edward D Huey, Yunglin Gazes, Sarah R Heilbronner, Campbell J Le Heron, Nora Vanegas-Arroyave

Faculty, Staff and Students Publications

Apathy, or loss of motivation, is a prominent syndrome accompanying both Alzheimer's and Parkinson's diseases, in addition to other disorders. One approach to understanding motivational loss is to examine the processes underlying goal-directed behaviour. Weighing up rewarding outcomes against the effort costs required to obtain them (effort-based decision-making) is a core computation when deciding to act for outcomes. Although a growing body of evidence points to disruption of this computation in people with apathy, which underlying decision parameters drive this disruption, their neural associations and whether these would generalize or differ across brain disorders have not been examined. People with …

Cracks In The Earth: Why Is East Africa Losing Its Soil?, Maarten Wynants, Aloyce Amasi, Will Blake, Pascal Boeckx, Andrew Brooks, Claire Kelly, Ivan Lizaga, Linus Munishi

School of Geography, Earth and Environmental Sciences

No abstract provided.

Timing Isn't Everything: Rethinking Mortality Risk In Type A Aortic Dissection Surgery, Anna H Xue, Joseph S Coselli

Faculty, Staff and Students Publications

No abstract provided.

Purine Metabolic Adaptation Protects The Endothelium From Disturbed Flow-Induced Dna Damage And Atherosclerosis, Qian Ma, Yongfeng Cai, Zhidan Zhang, Dingwei Zhao, Yuan Zhao, Peishan Xu, Tammy Lu, Wendy Zhang, Qiuhua Yang, Yaqi Zhou, Varadarajan Sudhahar, Tohru Fukai, Hanjoong Jo, Yiming Xu, Yuqing Huo

Faculty, Staff and Students Publications

Despite effective lipid-lowering therapies, atherosclerosis continues to be a leading cause of death, with considerable residual cardiovascular risk. Atherosclerotic lesions develop preferentially at arterial regions exposed to disturbed flow (d-flow), which induces genomic stress, endothelial injury, and barrier dysfunction. Hemodynamic forces are known to reprogram endothelial metabolism, but the role of de novo purine synthesis (DNPS), which supplies nucleotides for genome maintenance and whose terminal steps are catalyzed by the bifunctional enzyme ATIC, remains undefined in atherosclerosis. By integrating bulk and single-cell multiomics with in vitro flow systems and in vivo models, we show that d-flow upregulates DNPS and ATIC …

Early-Stage Rectal Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm Treated With Local Excision In A Frail Elderly Patient: A Multidisciplinary Management Dilemma, Christopher M. Ahmad, Rae-Anne Kastle, Talyn Smith, Harsha Kalagana, Kerry Williams-Wuch

Student Publications

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) of the rectum are rare tumors that typically demonstrate aggressive behavior, largely driven by high-grade neuroendocrine carcinoma components. Evidence guiding management is limited, particularly for early-stage lesions and for patients unable to tolerate standard oncologic surgery. We report the case of an elderly man with extensive comorbidities who was found to have a 1.3 cm rectal MiNEN following transanal endoscopic microsurgery (TEMS) performed for rectal bleeding. Histopathology revealed a moderately differentiated adenocarcinoma component and a well-differentiated grade 1 neuroendocrine tumor (NET) component, with submucosal invasion greater than 2 mm, negative margins, low tumor budding, small-vessel lymphovascular …

Transcriptome Predictors Of Second Breast Events In Ductal Carcinoma In Situ: A Case‒Control Study Including Black And White Women, Aditi Hazra, Emma Berdan, Thomas Walsh, Sarah Humble, Jen Tappenden, Katherine Deschryver, Deborah Veis, Kiran Vij, Shannan Ho Sui, Graham A Colditz

2020-Current year OA Pubs

BACKGROUND: Black women diagnosed with ductal carcinoma in situ (DCIS) experience disproportionately higher risk of second breast cancer events (SBEs), including both ipsilateral and contralateral recurrences, yet remain underrepresented in molecular biomarker studies compared to non-Hispanic White women.

METHODS: We performed RNA sequencing on 200 archival DCIS samples from the Resource of Archival Breast Tissue cohort, including 33% self-reported Black women. We correlated transcriptomic and clinical data to identify predictors of SBEs. Cases (n = 100) who developed SBEs between 1999 and 2019 were matched 1:1 to controls (n = 100) on age, race, and margin status, who remained event-free …