Digital Commons Network^™

Assessing Hydrolysis Performance Of Ce(Oh)4@Pim-1 Composites Functionalized With Amidoxime, Aldoxime, And Carboxylate Groups Toward Dimethyl 4-Nitrophenylphosphonate, A Nerve Agent Simulant, Peter O. Aina, Sukanta K. Mondal, Ali A. Rownaghi, Fateme Rezaei

Chemical and Biochemical Engineering Faculty Research & Creative Works

In recent years, significant attention has been directed toward evaluating the reactivity of diverse polymers to gauge their catalytic activity against hazardous chemicals. Among these polymers, pim-1 has emerged as an exceptional candidate due to its noteworthy attributes including high surface area, excellent solubility, and the capability to fine-tune the nitrile functional groups along its polymeric backbone. In this study, we explored the impact of different functional groups, such as amidoxime (ax), aldoxime (ox), and carboxylate (cooh), on the degradation of dimethyl 4-nitrophenylphosphonate (dmnp) in comparison to pure pim-1 and their respective ce(oh)4-loaded polymer composites. Remarkably, the pim-1-ax analog exhibited …

Finals Week Treasures, University Of Dayton

University Libraries Blog Archive

Inspired by Netflix’s Outer Banks, Roesch Library’s finals week services will be treasured by Pogues and Kooks alike.

Coronary Microvascular Dysfunction In Childhood: An Emerging Pathological Entity And Its Clinical Implications, Takeshi Tsuda, Gina Patel

Department of Pediatrics Faculty Papers

Coronary microvascular dysfunction (CMD) encompasses a spectrum of structural and functional alterations in coronary microvasculature resulting in impaired coronary blood flow and consequent myocardial ischemia without obstruction in epicardial coronary artery. The pathogenesis of CMD is complex involving both functional and structural alteration in the coronary microcirculation. In adults, CMD is predominantly discussed in context with anginal chest pain or existing ischemic heart disease and its risk factors. The presence of CMD suggests increased risk of adverse cardiovascular events independent of coronary atherosclerosis. Coronary microvascular dysfunction is also known in children but is rarely recognized due to paucity of concommitent …

Cross-Contamination Of Crispr Guides And Other Unrelated Nucleotide Sequences Among Commercial Oligonucleotides, Hiroshi Arakawa, Hiromi Miura, Rolen M. Quadros, Masato Ohtsuka, Channabasavaiah B. Gurumurthy

Journal Articles: Genetics, Cell Biology & Anatomy

Custom oligonucleotides (oligos) are widely used reagents in biomedical research. Some common applications of oligos include polymerase chain reaction (PCR), sequencing, hybridization, microarray, and library construction. The reliability of oligos in such applications depends on their purity and specificity. Here, we report that commercially available oligos are frequently contaminated with nonspecific sequences (i.e. other unrelated oligonucleotides). Most of the oligos that we designed to amplify clustered regularly interspersed palindromic repeats (CRISPR) guide sequences contained nonspecific CRISPR guides. These contaminants were detected in research-grade oligos procured from eight commercial oligo-suppliers located in three different geographic regions of the world. Deep sequencing …

Gaza War: Too Many Citizens Being Killed, Sheraz Yaqub, Bjørn Edwin, Zane Hammoud, Gabriel Herrera-Almario, Buthaina Jabir, Kristoffer Lassen, Pål Dag Line, Miguel Angel Lopez-Gonzalez, Michael Puttick, Mohammed Ahmed Idrees Saadelnour, José Sampaio-Neto, Raghuram Sampath, Konstantin V. Sementsov, Ajith K. Siriwardena, Ernesto Sparrelid, Alberto Büge Stein, Robert Sutcliffe, Helena Taflin, Hany Takla, Silvio Valdec, Cherisse N. Vinoya, Waleed Zaid, Stephen J. Wigmore

School of Dentistry Faculty Publications

No abstract provided.

Diverse Habitats Shape The Movement Ecology Of A Top Marine Predator, The White Shark Carcharodon Carcharias, Oliver J. D. Jewell, Taylor K. Chapple, Salvador J. Jorgensen, Paul Kanive, Jerry H. Moxley, James R. Tweedley, Scot Anderson, Barbara A. Block, Adrian C. Gleiss

Marine Science Faculty Publications and Presentations

An animal's movement is influenced by a plethora of internal and external factors, leading to individual- and habitat-specific movement characteristics. This plasticity is thought to allow individuals to exploit diverse environments efficiently. We tested whether the movement characteristics of white sharks Carcharodon carcharias differ across ontogeny and among habitats along the coast of Central California. In doing so, we elucidate how changes in internal state (physiological changes coinciding with body size) and external environments (differing seascapes and/or diel phases) shape the movement of this globally distributed predator. Twenty-one white sharks, from small juveniles to large adults, were equipped with motion-sensitive …

Assessing Higher Order Thinking In The New Jersey Social Studies Standards For Grades K-8 By Using Artificial Intelligence (Ai), Connie Sanchez

Seton Hall University Dissertations and Theses (ETDs)

New Jersey consistently ranks as one of the top-performing states in the country when it comes to education. Most recently, it was ranked third in the nation. A look at the state standards in any subject shows the state works diligently to vertically align standards while also challenging students in order to better prepare them for the future and to be able to live in a global society. It is evident in looking at the New Jersey Department of Education’s standards that the planning they do is performed with an eye toward the future. The social studies standards are no …

A New Vicarious Technique For Radiometric And Spatial Calibration Of Drone-Based Multispectral And Hyperspectral Imaging Systems, David N. Conran

Theses

A new technology (convex mirrors) used for radiometric and spatial characterization of remote sensing imaging systems has demonstrated equal, but unique results when compared to Lambertian targets for vicarious calibration. Using convex mirrors to characterize the radiometric and spatial response of hyperspectral and multispectral imaging systems has yet to be thoroughly investigated for drone-based platforms. When imaged, a convex mirror produces a known radiant intensity source that can characterizes the radiometric and spatial performance of an imaging system. The simultaneous assessment supports a unique understanding of the hyperspectral and multispectral instrument’s response for vicarious characterization. Assessing a new technique for …

Corrigendum: A Single-Institution Experience With 177lu Rpt Workflow Improvements And Qualifying The Spect/Ct Imaging For Dosimetry, Siju George, Ranjini Tolakanahalli, Santiago Aguirre, Vivek Mishra

All Publications

No abstract provided.

Capn2 Correlates With Insulin Resistance States In Pcos As Evidenced By Multi-Dataset Analysis, Xi Luo, Yunhua Dong, Haishan Zheng, Xiaoting Zhou, Lujuan Rong, Xiaoping Liu, Yun Bai, Yunxiu Li, Ze Wu

Faculty, Staff and Student Publications

OBJECTIVE: IR emerges as a feature in the pathophysiology of PCOS, precipitating ovulatory anomalies and endometrial dysfunctions that contribute to the infertility challenges characteristic of this condition. Despite its clinical significance, a consensus on the precise mechanisms by which IR exacerbates PCOS is still lacking. This study aims to harness bioinformatics tools to unearth key IR-associated genes in PCOS patients, providing a platform for future therapeutic research and potential intervention strategies.

METHODS: We retrieved 4 datasets detailing PCOS from the GEO, and sourced IRGs from the MSigDB. We applied WGCNA to identify gene modules linked to insulin resistance, utilizing IR …

Application Of High-Deflection Strain Gauges To Characterize Spinal-Motion Phenotypes Among Patients With Clbp, Spencer Alan Baker

Theses and Dissertations

Chronic low back pain (CLBP) is a nonspecific and persistent ailment that entails many physiological, psychological, social, and economic consequences for individuals and societies. Although there is a plethora of treatments available to treat CLBP, each treatment has varying efficacy for different patients, and it is currently unknown how to best link patients to their ideal treatment. However, it is known that biopsychosocial influences associated with CLBP affect the way that we move. It has been hypothesized that identifying phenotypes of spinal motion could facilitate an objective and repeatable method of determining the optimal treatment for each patient. The objective …

Evaluation Of Seizure Recognition And First Aid Training Course And Improving Self-Efficacy Related To Medical Emergencies In Mississippi, Anna Katherine Herrington, Collin Earl Wayne Crawson, Daniel Robert Zuckerman

Honors Theses

Within recent years, there has been increased attention to the growing physician shortage across the United States. This shortage has placed substantial strain upon regions of lower healthcare access, particularly those of rural regions such as much of the state of Mississippi. As rural healthcare providers are placed under more strenuous conditions, they encounter issues of increased patient volume, lack of a trauma team, or adequate transportation to higher-level care facilities. These issues may exacerbate the present inequities in cost of living, access to adequate healthcare, and the distress caused by these concerns. Individuals with epilepsy are one cohort with …

New-Onset Depression Following Total Shoulder Arthroplasty: The Impact Of Preoperative Patient Factors And Postoperative Complications, Kevin X. Farley, Robert S. Dean, Eric R. Wagner, Michael B. Gottschalk, J Michael Wiater

Conference Presentation Abstracts

OBJECTIVE: Depression has been well studied as a risk factor for postoperative complications following total shoulder arthroplasty (TSA). However, little is known about new-onset depression (NOD) following TSA. The purpose of this study is to determine the incidence of NOD following TSA and identify risk factors for its occurrence. METHODS: This was a retrospective review of patients undergoing TSA in the Truven Health MarketScan database. NOD was identified. Patients with preoperative depression were excluded from analysis. Postoperative complications were identified, including the development of a prosthetic joint infection (PJI), need for revision surgery, and postoperative dislocation. If a complication occurred …

Trends And Outcomes Of Same-Day Discharge Total Ankle Arthroplasty In The United States: A National Analysis From 2012-2021, Kevin X. Farley, Robert S. Dean, Ricky Sareini, Elijah Auch, Zachary Vaupel, Paul T. Fortin

Conference Presentation Abstracts

OBJECTIVE: Same-day discharge Total Ankle Arthroplasty (TAA) is becoming more common. This study sought to report the percentage of patients within a national database that had a same-day discharge following TAA, and to compare the complication rates for patients that had same-day discharge to those that had a short hospital stay. METHODS: From 2012-2021, the National Surgical Quality Improvement Project (NSQIP) database was used to identify all patients undergoing TAA. All patients discharged to their home on the day of surgery were identified. A comparison cohort of patients with a hospital stay of 1 to 2 days who were then …

Mass Incarceration, Violent Crimes, And Lengthy Sentences: Using The Race-Class Narrative As A Messaging Framework For Shortening Prison Sentences, Eric Petterson

St. Mary's Law Journal

No abstract provided.

Restore Texas Land: A Proposal To Utilize Emission Reduction Credits To Fund The Railroad Commission Of Texas' Well Plugging Initiative, George Coates Roberts

St. Mary's Law Journal

No abstract provided.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Combined Deletion Of Men1, Atrx And Pten Triggers Development Of High-Grade Pancreatic Neuroendocrine Tumors In Mice, Mary Esmeralda Fuentes, Xiaoyin Lu, Natasha M Flores, Simone Hausmann, Pawel K Mazur

Faculty, Staff and Student Publications

Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of tumors that exhibit an unpredictable and broad spectrum of clinical presentations and biological aggressiveness. Surgical resection is still the only curative therapeutic option for localized PanNET, but the majority of patients are diagnosed at an advanced and metastatic stage with limited therapeutic options. Key factors limiting the development of new therapeutics are the extensive heterogeneity of PanNETs and the lack of appropriate clinically relevant models. In that context, genomic sequencing of human PanNETs revealed recurrent mutations and structural alterations in several tumor suppressors. Here, we demonstrated that combined loss of MEN1, …

In Silico And In Vitro Study Of Isoquercitrin Against Kidney Cancer And Inflammation By Triggering Potential Gene Targets, Safia Iqbal, Md Rezaul Karim, Shahnawaz Mohammad, Jong Chan Ahn, Anjali Kariyarath Valappil, Ramya Mathiyalagan, Deok-Chun Yang, Dae-Hyo Jung, Hyocheol Bae, Dong Uk Yang

Faculty, Staff and Student Publications

Kidney cancer has emerged as a major medical problem in recent times. Multiple compounds are used to treat kidney cancer by triggering cancer-causing gene targets. For instance, isoquercitrin (quercetin-3-O-β-d-glucopyranoside) is frequently present in fruits, vegetables, medicinal herbs, and foods and drinks made from plants. Our previous study predicted using protein-protein interaction (PPI) and molecular docking analysis that the isoquercitrin compound can control kidney cancer and inflammation by triggering potential gene targets of IGF1R, PIK3CA, IL6, and PTGS2. So, the present study is about further in silico and in vitro validation. We performed molecular dynamic (MD) simulation, gene ontology (GO), Kyoto …

Phase 1b Study Of Intraperitoneal Ipilimumab And Nivolumab In Patients With Recurrent Gynecologic Malignancies With Peritoneal Carcinomatosis, Anne Knisely, Emily Hinchcliff, Bryan Fellman, Ann Mosley, Kathryn Lito, Sara Hull, Shannon N Westin, Anil K Sood, Kathleen M Schmeler, Jolyn S Taylor, Steven Y Huang, Rahul A Sheth, Karen H Lu, Amir A Jazaeri

Faculty, Staff and Student Publications

Background: Intravenous immune checkpoint blockade (ICB) has shown poor response rates in recurrent gynecologic malignancies. Intraperitoneal (i.p.) ICB may result in enhanced T cell activation and anti-tumor immunity.

Methods: In this phase 1b study, registered at Clinical.

Trials: gov (NCT03508570), initial cohorts received i.p. nivolumab monotherapy, and subsequent cohorts received combination i.p. nivolumab every 2 weeks and i.p. ipilimumab every 6 weeks, guided by a Bayesian design. The primary objective was determination of the recommended phase 2 dose (RP2D) of the combination. Secondary outcomes included toxicity, objective response rate (ORR), progression-free survival (PFS), and overall survival (OS).

Findings: …

My Journey In Researching Depression Among Black People: Experiences Of A Researcher In A Sensitive Study, Brightness L. Kgatla

The Qualitative Report

The interest in qualitative research on mental health within Black communities is rapidly growing. However, there are still debates on the conceptualization of depression among the Black community. This paper focuses on the researcher’s experiences as a young Black South African experiencing depression, and their reflections on interpretivist qualitative research focused on the realities of Black South African youth experiencing depression. The paper highlights the importance of reflexivity in a qualitative study and how the topics researched by a Black South African experiencing depression which is still considered a taboo within some parts of the Black community. If a researcher …

Time-Dependent Strain-Resistance Relationships In Silicone Nanocomposite Sensors, Alex Mikal Wonnacott

Theses and Dissertations

Flexible high-deflection strain gauges have been demonstrated as cost-effective and accessible sensors for capturing human biomechanical deformations. However, the interpretation of these sensors is notably more complex compared to conventional strain gauges, partially owing to the viscoelastic nature of the strain gauges. On top of the non-linear viscoelastic behavior, dynamic resistance response is even more difficult to capture due to spikes in resistance during strain changes. This research examines the relationships between stress, strain, and resistance in nanocomposite sensors during dynamic strain situations. Under the assumption that both macroscopic stress and resistance are governed by microscopic stress concentrations at the …

High Data Rate Signal Processing Architectures And Compilation Strategies For Scalable, Multi-Gigabit Digital Systems, Daniel Alexander Nybo

Theses and Dissertations

In this study we present a high-performance computing architecture and hardware acceleration strategy for a heterogeneous multi-gigabit computing system. The system architecture integrates a BeeGFS distributed file system, capable of achieving 80 Gbps of sustained write throughput across five nodes, essential for managing the high data volumes generated by a 25 high performance computer (HPC) compute cluster. To ensure operational efficiency and scalability, the tasks performed on the Linux compute cluster consisting of 30 nodes are automated using Ansible, facilitating seamless deployment, management, and updates. We present compilation strategies for a hardware accelerated Polyphase Filter Bank (PFB) channelization routine optimized …

Comics About Organs: Social Support And Graphic Medicine In The Awkward Yeti, Jacob Gibb

Theses and Dissertations

Comic strips have always been a medium for more than humor. Many comic strips published on social media sites address mental health issues. Despite their popularity, the field of graphic medicine, which examines the intersection of health care and comics, has seen little to no examination of how these comics function on social media. Utilizing the popular comic The Awkward Yeti, this research examines how the rhetorical devices of comics make them an ideal medium for communicating about mental health issues and providing social support to social media users. This study conducts a content analysis of 15 Instagram posts from …

Serum Neuroactive Metabolites Of The Tryptophan Pathway In Patients With Acute Phase Of Affective Disorders, Yanli Li, Leilei Wang, Junchao Huang, Ping Zhang, Yanfang Zhou, Jinghui Tong, Wenjin Chen, Mengzhuang Gou, Baopeng Tian, Wei Li, Xingguang Luo, Li Tian, L Elliot Hong, Chiang-Shan R Li, Yunlong Tan

Faculty, Staff and Student Publications

BACKGROUND: Many studies showed disrupted tryptophan metabolism in patients with affective disorders. The aims of this study were to explore the differences in the metabolites of tryptophan pathway (TP) and the relationships between TP metabolites and clinical symptoms, therapeutic effect in patients with bipolar disorder with acute manic episode (BD-M), depressive episode (BD-D) and major depressive disorder (MDD).

METHODS: Patients with BD-M (n=52) and BD-D (n=39), MDD (n=48) and healthy controls (HCs, n=49) were enrolled. The serum neuroactive metabolites levels of the TP were measured by liquid chromatography-tandem mass spectrometry. Hamilton Depression Scale-17 item (HAMD-17) and Young Mania Rating Scale …

Photophobia Is Associated With Lower Sleep Quality In Individuals With Migraine: Results From The American Registry For Migraine Research (Armr), Nina Sharp, Mark J Burish, Kathleen B Digre, Jessica Ailani, Mahya Fani, Sophia Lamp, Todd J Schwedt

Faculty, Staff and Student Publications

BACKGROUND: Patients with migraine often have poor sleep quality between and during migraine attacks. Furthermore, extensive research has identified photophobia as the most common and most bothersome symptom in individuals with migraine, second only to headache. Seeking the comfort of darkness is a common strategy for managing pain during an attack and preventing its recurrence between episodes. Given the well-established effects of daily light exposure on circadian activity rhythms and sleep quality, this study aimed to investigate the relationship between photophobia symptoms and sleep quality in a cohort of patients with migraine.

METHODS: A cross-sectional observational study was conducted using …

Escalating Conflict-Related Sexual And Gender Violence In The Ongoing Sudan Conflict, Agnes Poplawski

Cardozo International & Comparative Law Review (CICLR) Blog

Since its independence from Great Britain and Egypt in the late 1950s, Sudan has been in a state of perpetual internal conflict. When Omar al-Bashir seized power and became Sudan’s president in 1989, the state had split into northern and southern Sudan, resulting in South Sudan’s secession. Sudan’s economy began to deteriorate, mass street protests erupted, and the military-civilian government was soon created and overthrown in 2021 when General Abdel Fattah al-Burhan took over. Since this time, the country had been run by a council of generals led by two military figures from opposing groups, bringing us to Sudan’s current …

27th Annual Women's, Gender, And Sexuality Studies Symposium Program, 2024, Illinois State University, Women's, Gender, And Sexuality Studies Program

WGSS Student Research Symposium

Program from the Women's, Gender, and Sexuality Studies Symposium

Growth And Yield Response Of Watani Wado Job's Tears (Coix Lacryma-Jobi L.) To The Application Frequency Of Phosphate Fertilizer And Paclobutrazol In Different Growing Seasons, Arifa Syahanna Mahdya, Rizka Farahdillah, Muhamad Kadapi, Tati Nurmala

Jurnal Kultivasi

Job's tears (Coix lacryma-jobi L.) is a carbohydrate source functional food crop that can be developed as a substitute for rice. This study aims to determine the best application frequency of phosphate (P) fertilizer and paclobutrazol for supporting the growth and yield of job's tears in both rainy and dry seasons. The research was conducted from November 2021 - November 2022 at the Ciparanje research station and Laboratory Centre Universitas Padjadjaran, Jatinangor, Sumedang. The experiment used a randomized block design (RBD) consisting of P fertilizer application frequency (once, twice, and thrice) and paclobutrazol application frequency (once, twice, and thrice) and …

Health Professional Students Receiving Osteopathic Manipulative Treatment: An Interdisciplinary And Interprofessional Activity To Improve Attitudes Towards Osteopathic Medicine And Interprofessional Collaboration, Nicole Neiman, Justinas Joksas, Erica Sickel, Anne Marie Zeller

Research Day

No abstract provided.