Digital Commons Network^™

Tissue Doppler Imaging, Pulmonary Haemodynamics And Conventional Echocardiographic Indices For Early Bronchopulmonary Dysplasia Prediction In Preterm Infants: A Prospective Observational Feasibility Study, Wisam Muhsen, Joanne Hosking, Jos M. Latour, Eirik Nestaas

School of Nursing and Midwifery

Background/Objectives: Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity, yet no prediction model incorporating echocardiographic assessment of right ventricle (RV) function and pulmonary haemodynamics exists. This study aimed to identify clinical and echocardiographic candidate variables of BPD to inform the design of a future multicentre study for BPD prediction model construction. Methods: This prospective observational feasibility study recruited preterm infants born before 32 weeks of gestation. Echocardiographic scans were performed at Day 5 and Day 9 postnatally. Candidate variables across six domains, clinical, RV systolic, diastolic, and global function, pulmonary-haemodynamics, and patent ductus arteriosus (PDA) variables, were evaluated using …

Progressive Cardiac Phenotypes And Reduced Reversibility From Long-Term Cugexp Rna Expression In A Dm1 Mouse Model, Rong-Chi Hu, Mohammadreza Tabary, Xander Ht Wehrens, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is caused by an expanded CTG repeat in the DMPK gene, resulting in mutant transcripts that form expanded CUG (CUGexp) RNA foci and sequester muscleblind-like (MBNL) RNA-binding proteins. DM1 is multisystemic, with progressive worsening of disease manifestations in affected tissues. Disease progression is attributed to somatic expansion of the CTG repeats with age, resulting in production of CUGexp RNA with enhanced intrinsic toxicity due to increased MBNL sequestration. To determine the degree to which cardiac disease progression can occur independently of repeat expansion, we used a transgenic DM1 mouse model with inducible heart-specific expression of …

Enhancing Psychiatry Residents’ Knowledge And Comfort With Clozapine Prescribing Through Educational Interventions, Christopher Stewart, Alexander Hunter, Faith Franzwa, Quan Huynh, Jennifer Stettler, Nauman Ashraf, Dawny M. Barnhart

Student Publications

Introduction: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia but remains underutilized due to safety concerns and monitoring complexity. Recent discontinuation of the Clozapine Risk Evaluation and Mitigation Strategy (REMS) program reduced regulatory barriers but shifted responsibility for monitoring to clinicians. Psychiatry residents may lack adequate training and confidence to prescribe clozapine safely in this new context. The goal of this study is to evaluate the impact of a structured educational intervention on psychiatry residents’ knowledge of clozapine prescribing and management.

Methods: This study was a single-institution quality improvement study using a pre-post design. Participants were psychiatry residents from …

Gaboxadol Increases Resting Theta And Alpha Power Without Affecting Evoked Responses In Fragile X Syndrome In A Home-Based Setting., Lisa A. De Stefano, Hyeonseok Kim, Craig A. Erickson, Lauren M. Schmitt, Kelli C. Dominick, Ernest V. Pedapati, Richard Huckle, Robert Wilson, Walker S. Mckinney Ph.D., Debra L. Reisinger, Meredith N. Nelson, Ashley E. Dapore, Paul S. Horn, Makoto Miyakoshi

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Fragile X syndrome (FXS) lacks FDA-approved treatments despite various small molecules contributing to phenotypic rescue in the FMR1 knockout (KO) mouse model. Translation from the mouse model has been hampered by phenotypic heterogeneity that contributes to participation barriers among participants who are most affected and may be unable to regularly visit the research laboratory. The current study utilized a crossover design to test the acute neural and behavioral effects of a single 10 mg dose of gaboxadol and the reliability of electroencephalography (EEG) and behavioral data collected in participant homes compared to the clinic.

METHODS: Ten adult males with …

Comparative Effectiveness Of Low Versus High Dose Upadacitinib As Maintenance Treatment In Patients With Ulcerative Colitis: A Real-World Cohort Study From The United States, Priya Sehgal, Gursimran S. Kochhar, Harpreet Kaur, Himsikhar Khataniar, Raina Shivashankar, James D. Lewis, Aakash Desai

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: There is limited real-word data comparing efficacy of low dose upadacitinib (UPA) to high dose UPA as maintenance therapy for ulcerative colitis (UC).

METHODS: This was a retrospective cohort study utilizing the U.S. Collaborative Network in adults ≥18 years old with UC who initiated UPA 15 mg compared to 30 mg for maintenance therapy between April 2022 and December 2023. The primary outcome was a composite of intravenous steroid use, oral steroid use, or colectomy from 12 to 60 weeks from the index UPA prescription. Propensity score matching (PSM) was performed for demographics, co-morbid conditions, laboratory, and IBD medication …

Peran Regulasi Dalam Penanggulangan Masalah Keamanan Informasi Suatu Pendekatan Normatif Sosiologis, Freddy Harris, Bono Budi P.

Jurnal Hukum & Pembangunan

Abstract

Nature As The Foundation: A Shift In Pedagogy, Mary Moroney-Fernandez

The Cicadian

Somewhere in the United States right now, a child is sitting beneath fluorescent lights while the world outside continues without her. This paper argues that her confinement is not accidental, but rather theoretical. Examining the divergent frameworks of Friedrich Fröbel and Jean Piaget, it traces how American public schooling absorbed a vision of learning organized around cognitive individualism while displacing Fröbel's relational vision of child and nature. Drawing on reflection, historical analysis, and research, this paper contends that lasting reform requires confronting the foundational assumptions that built the classroom in the first place.

Nature Writing As A Bridge To Student Scientific Interest, Christine Mcgrail, John Kudukey, Colette Smith, Fnu Dharma

The Cicadian

Nature writing is an important pathway for preservice teachers’ engagement with science that can help more students recognize themselves as knowers and doers of science and better connect them and their students to the world around them. Nature writing allows all students, including those from non-dominant cultural backgrounds, to include their experiences and backgrounds in their science education. Nature writing also affords all students an opportunity to better understand the natural world they are a part of. Nature writing is typically written in first person and characterized as scientific observation of the natural world through a personal reflective lens. In …

Arkansas Educators' Views On Corporal Punishment: Demographic Influences And Social Work Implications, Phillip Hill, Esaa Samarrah

Research and Creative Works Expo

Corporal punishment (CP) in U.S. public schools, defined as "the use of physical force with the intention of causing a child to experience pain so as to correct their misbehavior" (Gershoff & Font, 2016), remains legal in 17 states despite mounting evidence of its ineffectiveness and disproportionate harm to marginalized students. This study presents survey data from 94 Arkansas public school educators, examining their knowledge of legality, personal and indirect experiences with CP, perceptions of its effectiveness, and attitudes toward its continued use. Analyses were conducted using IBM SPSS Statistics, with reverse coding applied to the negative-impact Likert items so …

Photophysical Properties Of Tunable Dox-Ir820 Chemo-Ptt Combination Nanomedicine, Eshaal Nadeem, Fatima Abbas, Noureen Siraj

Research and Creative Works Expo

Cancer remains the second leading cause of death in the United States, underscoring the urgent need for more effective treatment options. Nanotechnology offers innovative solutions through combination nanomedicines that can integrate multiple therapeutic mechanisms into a single platform. In this study, we developed aqueous nanoparticles (NPs) composed of a combined chemotherapeutic agent and photothermal therapy drug,[DOX][IR820], using a simple reprecipitation method. By adjusting different parameters, we tuned NP size and evaluated how this influenced their photophysical behavior, such as absorbance and fluorescence emission, and photothermal therapeutic activity such as light-to-heat conversion efficiency. These properties were analyzed to identify the optimal …

Vda Offers Media Opportunities, Elise Rupinski

Virginia Dental Journal

No abstract provided.

Finding Mentorship In The Dental Profession, Amanda Toulme Dds

Virginia Dental Journal

No abstract provided.

Cdhc - The First Graduates, Parker Coulson Cdhc

Virginia Dental Journal

No abstract provided.

Mom Provides Dental Care For Richmond’S Homeless, Michael Rogers

Virginia Dental Journal

No abstract provided.

It's Working - Virginia's Cdhc Program, David E. Black Dds

Virginia Dental Journal

No abstract provided.

Ada's Find-A-Dentist Campaign Takes Off In Virginia, Elise Rupinski

Virginia Dental Journal

No abstract provided.

Government Relations, Tripp Perrin, Chuck Duvall

Virginia Dental Journal

No abstract provided.

What You Need To Know- From The December 2017 Virginia Board Of Dentistry Meeting, Ursula Klostermyer Dds, Phd, David E. Black Dds

Virginia Dental Journal

No abstract provided.

Medicare Basics- What You Need To Know As You Approach Age 65, Larry Bedsole Jr.

Virginia Dental Journal

No abstract provided.

To Join, Or Not To Join, That Is The Question, Elizabeth Reynolds Dds

Virginia Dental Journal

No abstract provided.

Integration Of A Preventative Dental Care Coordinator Within A Long-Term Care Facility- A Pilot Study To Determine Efficacy In Two Long-Term Care Facilities In Virginia, Frank Iuorno Jr., Dds, Patricia B. Bonwell Rdh, Bsdh, Msh, Phd, Lyubov D. Slashcheva Dds, Marcia Rhodes Rdh

Virginia Dental Journal

No abstract provided.

Letter To The Editor- Dentists Save Lives, Marvin E. Pizer Dds, Ms, Ma, Ficd

Virginia Dental Journal

No abstract provided.

What You Can Learn From A Recent Hipaa Scandal, Amelia W. Destefano

Virginia Dental Journal

No abstract provided.

Letter To The Editor- Don't Slice Your Finger, Henry M. Botuck Dds

Virginia Dental Journal

No abstract provided.

Nfpa 99 And The Dental Office, Jonathan L. Wong Dmd, Gerhard Gschwandtner P.Eng

Virginia Dental Journal

No abstract provided.

Trustee's Corner No More Business As Usual, Kirk Norbo Dmd

Virginia Dental Journal

No abstract provided.

Message From The Editor, Richard F. Roadcap Dds

Virginia Dental Journal

No abstract provided.

President’S Message, Benita Miller Dds

Virginia Dental Journal

No abstract provided.

Va Dent J January, February And March 2018

Virginia Dental Journal

No abstract provided.

Hidden In Plain Sight: A Critical Examination Of The Sec’S Climate Disclosure Rule And Shortcomings In Addressing Multinational Instances Of Industrial Pollution, Charity Christina Williams

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.