Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (325780)
- Social and Behavioral Sciences (259240)
- Law (183146)
- Education (153957)
- Arts and Humanities (123212)
-
- Life Sciences (116434)
- Medical Specialties (77032)
- Physical Sciences and Mathematics (64841)
- Higher Education (59357)
- Public Health (55643)
- Business (51253)
- History (50476)
- Psychology (48833)
- Medical Sciences (45194)
- Sociology (43965)
- Communication (43609)
- Engineering (41047)
- Nursing (34141)
- Public Affairs, Public Policy and Public Administration (33192)
- Library and Information Science (25740)
- Environmental Sciences (24937)
- United States History (21830)
- Religion (21812)
- Diseases (21751)
- Journalism Studies (21680)
- Mass Communication (21326)
- Educational Administration and Supervision (18004)
- Economics (17950)
- Rehabilitation and Therapy (16629)
- Social History (16393)
- Institution
-
- University of New Mexico (56018)
- University of New Hampshire (43697)
- University of Nebraska - Lincoln (37647)
- University of Montana (27877)
- The Texas Medical Center Library (27454)
-
- University of Colorado Law School (24806)
- University of Mississippi (24678)
- University of South Florida (22929)
- Murray State University (21689)
- Washington University School of Medicine (20184)
- University of Kentucky (18291)
- Georgia Southern University (18175)
- San Jose State University (17419)
- Chulalongkorn University (17317)
- Walden University (16767)
- Utah State University (16513)
- Western Kentucky University (16401)
- Thomas Jefferson University (16382)
- Western Michigan University (16145)
- Gallaudet University (15146)
- Eastern Illinois University (15078)
- Sigma Theta Tau International Honor Society of Nursing (14730)
- Nova Southeastern University (14525)
- University of Central Florida (14425)
- University of Alabama at Birmingham (14418)
- Virginia Commonwealth University (14278)
- University of North Dakota (13937)
- California Polytechnic State University, San Luis Obispo (13717)
- Brigham Young University (12756)
- Bowling Green State University (12539)
- Keyword
-
- Newspaper (30168)
- Humans (28522)
- Female (13573)
- Education (13405)
- COVID-19 (12863)
-
- Student newspaper (12363)
- Male (11816)
- Newspapers (10319)
- Newsletter (9998)
- Animals (9188)
- Bowling Green State University (8945)
- Spartan Daily (8774)
- EIU (8523)
- Michigan (7935)
- History (7325)
- Higher education (7290)
- Eastern Illinois University (7249)
- United States (7247)
- Daily Eastern News (7141)
- Adult (7027)
- BG News (7010)
- Faculty (6313)
- N.M. (6305)
- Mental health (6222)
- Pennsylvania (6209)
- B.G. News (5981)
- Mice (5892)
- Collegeville (5821)
- Middle Aged (5769)
- Students (5680)
- Publication Year
-
- 2026 (48574)
- 2025 (75572)
- 2024 (79509)
- 2023 (77310)
- 2022 (76356)
-
- 2021 (76678)
- 2020 (74484)
- 2019 (65553)
- 2018 (61994)
- 2017 (60656)
- 2016 (57374)
- 2015 (53342)
- 2014 (48962)
- 2013 (45570)
- 2012 (44640)
- 2011 (38421)
- 2010 (35742)
- 2009 (32209)
- 2008 (29304)
- 2007 (26421)
- 2006 (24592)
- 2005 (22437)
- 2004 (20418)
- 2003 (18895)
- 2002 (17894)
- 2001 (16929)
- 2000 (16435)
- 1999 (15086)
- 1998 (14738)
- 1997 (14291)
- Publication
-
- Theses and Dissertations (30811)
- Walden Dissertations and Doctoral Studies (15576)
- Electronic Theses and Dissertations (15545)
- Faculty Publications (14368)
- Faculty, Staff and Student Publications (13689)
-
- Dissertations (12709)
- Session Laws 1951-2000 (12443)
- Faculty Scholarship (10225)
- Spartan Daily (School of Journalism and Mass Communications) (8078)
- Faculty, Staff and Students Publications (7732)
- Daily Mississippian (all digitized issues) (7637)
- Articles (7455)
- Open Access Publications (7412)
- 2020-Current year OA Pubs (7383)
- BG News (Student Newspaper) (7107)
- Santa Fe New Mexican, 1883-1913 (6966)
- Master's Theses (6843)
- Montana Kaimin, 1898-present (6764)
- Theses (6568)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (6481)
- Browse All News (6430)
- Masters Theses (6389)
- The Murray Ledger & Times (6370)
- Honors Theses (5931)
- Doctoral Dissertations and Projects (5824)
- Session Laws 2001-Present (5710)
- USF Tampa Graduate Theses and Dissertations (5473)
- International Nursing Research Congress (INRC) (5316)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (5148)
- Saudi Medical Journal (5073)
- Publication Type
Articles 16801 - 16830 of 1791765
Full-Text Articles in Entire DC Network
Consumer Reaction To Olympic Sponsorships, Bailey R. Wood
Consumer Reaction To Olympic Sponsorships, Bailey R. Wood
Honors Theses
The Olympic Games are the world’s premier sporting event, hosting athletes from 206 countries every four years. The Ancient Games date back over 3,000 years in what is now modern-day Greece. The “Classical Games” consisted of a single foot race, the “stade,” and eventually grew to include long-distance running, wrestling, long jump, javelin throw, and discus throw (Abrahams, n.d.). Now, the Games are split into summer and winter sports, with the Summer Olympic hosting 329 medal events and the Winter Olympics 116. Due to the size and magnitude of this event, the Olympic Games are broadcast all over the world, …
Controlling Fiscal Destiny: Evaluating The Effect Of State Tax Composition On Resilience During Defined Shock Period, Calloway R. Bills
Controlling Fiscal Destiny: Evaluating The Effect Of State Tax Composition On Resilience During Defined Shock Period, Calloway R. Bills
Honors Theses
State governments operate under strict fiscal constraints that limit their ability to respond to economic downturns through borrowing or monetary policy, making tax composition a key determinant of fiscal stability. This paper evaluates how variation in state tax revenue composition affects fiscal resilience during economic shocks, focusing on the Great Recession. While prior research shows that individual tax instruments differ in cyclicality, less is known about how overall tax structure shapes revenue performance during and after shocks. Using a panel dataset of U.S. states from 1988 to 2024, this study measures resilience through two outcomes: the magnitude of revenue decline …
Developing Spanish-Language Campus Tours To Enhance Accessibility And Competitive Recruitment At The University Of Mississippi, Caitlyn E. Culpepper
Developing Spanish-Language Campus Tours To Enhance Accessibility And Competitive Recruitment At The University Of Mississippi, Caitlyn E. Culpepper
Honors Theses
This thesis proposes and outlines an initiative that would bring Spanish-language campus tours and visit resources to the University of Mississippi, increasing accessibility to the campus visit experience while also providing institutional benefits within a competitive recruitment landscape. Through a review of current literature on Hispanic/Latino students in higher education, institutional enrollment and recruitment data, comparative research on peer institutions, and conversations with university professionals, this project explores the role that language accessibility, family engagement, and campus visits play in the college decision-making process.
Findings suggest that Hispanic/Latino students remain an underrepresented yet rapidly growing population in higher education and …
The Impact Of Patient Navigation On The Hepatitis C Care Continuum In Underserved Populations: A Scoping Review, Deauntaye Jones
The Impact Of Patient Navigation On The Hepatitis C Care Continuum In Underserved Populations: A Scoping Review, Deauntaye Jones
Honors Theses
Hepatitis C virus (HCV) remains a significant public health concern and is a leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation when left untreated. Although direct-acting antiviral therapies have made HCV curable for most patients, many underserved populations continue to experience barriers to diagnosis, linkage-to-care, treatment completion, and sustained virologic response (SVR). This study evaluated how patient navigation programs influence progression through the HCV care continuum among underserved populations. Relevant studies published between 2014 and 2025 were identified through searches of PubMed and Embase using terms related to HCV, patient navigation, linkage-to-care, underserved populations, and treatment outcomes. Following title, …
Hyposense: Multimodal Physiologic And Voc Wearable For Early Hypoglycemia Detection, Nidhi R. Patel
Hyposense: Multimodal Physiologic And Voc Wearable For Early Hypoglycemia Detection, Nidhi R. Patel
Honors Theses
Hypoglycemia remains a significant safety concern for insulin-dependent individuals, especially when blood glucose declines rapidly during exercise, sleep, or periods of impaired hypoglycemia awareness. Current continuous glucose monitors and automated insulin delivery systems have helped to improve diabetes management, but these technologies primarily respond to glucose trends after they have already started and may not actually provide sufficient warning before symptoms occur. This thesis describes the development of HypoSense, a noninvasive wrist worn wearable concept that is designed to support earlier hypoglycemia risk detection through multimodal physiologic and volatile organic compound emission sensing. HypoSense combines volatile organic compounds/gas sensing with …
Learning Through Play: The Effects Of Play-Based Instruction On Literacy Development, Jherica Goodgame
Learning Through Play: The Effects Of Play-Based Instruction On Literacy Development, Jherica Goodgame
Honors Theses
This thesis explores the role of play-based learning in early literacy development, emphasizing its impact on student engagement, executive functioning, and overall academic success. Drawing from research and personal experience, it argues that play is not separate from learning but a critical component of it. This thesis also highlights the benefits of play for diverse learners and examines the challenges teachers face in implementing play-based instruction. It provides numerous examples of play-based instruction practiced in a real classroom setting with 17 students who are varying from early kindergarten to late kindergarten levels. This thesis seeks to demonstrate the importance of …
What Do We Owe A Drowning Coast? Examining Louisiana's Coastal Crisis Through The Lens Of Environmental Justice, Owen M. Plaisance
What Do We Owe A Drowning Coast? Examining Louisiana's Coastal Crisis Through The Lens Of Environmental Justice, Owen M. Plaisance
Honors Theses
This thesis argues that human contributions to Louisiana’s coastal land loss constitute a form of environmental injustice that cannot be adequately addressed through frameworks focused solely on aggregate welfare or distributive fairness. While utilitarian and Rawlsian approaches offer important insights, both are limited in capturing the full scope of harm caused by environmental degradation. In coastal Louisiana, land loss undermines not only economic resources and physical security but also the substantive freedoms required for individuals and communities to live meaningful and culturally rooted lives, while disrupting ecological systems and non-human flourishing. To address these limitations, the thesis develops the Capabilities …
A Survey Of Lichen Native To Three Of Mississippi’S National Forests, William S. Granberry Iii
A Survey Of Lichen Native To Three Of Mississippi’S National Forests, William S. Granberry Iii
Honors Theses
Lichens are a major part of the environment for telling the air quality and the impact humans have on the environment. These signs go into how many species of lichen are present in a general area, and there has been a lack of a list of lichens that call Mississippi their home. The goal of this research is to help create this list through a survey of lichen in three of Mississippi’s National Forests: DeSoto, Homochitto, and Holly Springs. These three forests are ideal because they cover differing ecosystems and are in different parts of the state, heightening the chance …
Identity, Masculinity, And Stigma: Understanding Barriers To Mental Health Care Among African American Men, Landon H. Jones
Identity, Masculinity, And Stigma: Understanding Barriers To Mental Health Care Among African American Men, Landon H. Jones
Honors Theses
African American men are documented to underutilize health care services. Although the reasons for this pattern are complex, research suggests that both historical mistrust of the medical system and sociocultural expectations of strength, rooted in intersecting racial and masculine identities, might play key roles. These same factors may also influence attitudes toward mental health care. In the study, 267 African American men were randomly assigned to listen to a brief pro-health message delivered by either an in-group community member, a religious figure, or a neutral control speaker. Participants completed measures of racial identity importance, conformity to masculine norms, anticipated stigma, …
Gendered Politics Of Pictures: How Images In A Pakistani English Textbook Homogenize Female Identities, Liaquat Ali Channa
Gendered Politics Of Pictures: How Images In A Pakistani English Textbook Homogenize Female Identities, Liaquat Ali Channa
The Qualitative Report
This qualitative multimodal analytical study draws upon Kress and van Leeuwen’s ideas about pictures and problematizes textbooks of English that supposedly teach only English in Pakistan. It aims to understand the identities of an adult female as shown in the images of an English textbook. It uses Foucault’s theories of discourse and discursive formation, and a Vygotskian sociocultural view of the development of consciousness. By following Braun and Clarke (2006, 2019), all the pictures of the My English Book 4 are first analyzed thematically. Later, O’Toole’s (1994) method of analyzing pictures is employed for a detailed examination of a representative …
Mechanisms Underlying Diversity In Bacterial Biofilms, Jacob David Holt
Mechanisms Underlying Diversity In Bacterial Biofilms, Jacob David Holt
Dartmouth College Ph.D Dissertations
Bacteria commonly exist in natural environments as communities of multiple strains and species attached to surfaces and encased in an extracellular matrix of DNA, protein, and polysaccharides–termed biofilms. These biofilms contribute to diverse functions, from ocean carbon cycling via chitin degradation to pathogenic processes such as wound or implant colonization. The molecular mechanisms governing biofilm formation and composition have been well characterized in model pathogenic organisms, yet the extent to which aspects of biofilm formation contribute to the assembly and maintenance of diverse communities remains less well understood. Using microfluidics, confocal microscopy, and model biofilm-forming bacteria, this thesis details how …
Butte Priority Soils Operable Unit (Bpsou) 2026 Monthly Progress Report. Consent Decree For The Butte Priority Soils Operable Unit. Civil Action No. Cv 89-039-Bu-Seh, Josh Bryson
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Re: Conditional Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Clark Tailings Consolidated Waste Management Area (Ctcwma) Site Investigation Quality Assurance Project Plan (Qapp) (Dated April 16, 2026), Emma Rott
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Draft Final Butte Mine Waste Repository Operation And Maintenance (O&M) Plan, Pioneer Technical Services, Inc.
Draft Final Butte Mine Waste Repository Operation And Maintenance (O&M) Plan, Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Exploring Grounded Theory In Educational Research: Literature Review, Reflexivity, And Conceptual Development In Doctoral Research, Huidan Niu
The Qualitative Report
My article explores the application of grounded theory in educational research, focusing on the literature review process, reflexivity, and conceptual development. I address common misconceptions about grounded theory, especially for novice researchers, and advocate for its use as a comprehensive methodology rather than solely as a data analysis tool. Drawing on my doctoral research experience, I argue that grounded theory offers a valuable framework for fostering theoretical sensitivity and independence, making it particularly suitable for educational research. Through detailed examination, I offer novice researchers practical strategies for navigating the methodological complexities of grounded theory and for contributing conceptually robust and …
A Quality Improvement Initiative Evaluating Factors Influencing Patient Experience With Virtual Reality During Awake Interventional Radiology Procedures, Quynh Dao-Payne
A Quality Improvement Initiative Evaluating Factors Influencing Patient Experience With Virtual Reality During Awake Interventional Radiology Procedures, Quynh Dao-Payne
Doctoral Projects
Procedural anxiety and pain are common among pediatric patients undergoing awake interventional radiology (IR) procedures and may negatively affect patient comfort, cooperation, and overall patient experience. Virtual reality (VR) has emerged as a promising nonpharmacologic intervention to reduce anxiety and improve patient-centered outcomes. The purpose of this quality improvement project was to evaluate patient-reported experiences and perceived outcomes associated with VR use during awake pediatric IR procedures at Children’s Hospital Los Angeles. A qualitative descriptive quality improvement design was utilized. Twenty pediatric patients ages 10–21 years undergoing awake IR procedures with VR as part of standard clinical care completed structured …
Building Ai Literacy Through Assessment Practices In Physical Education Teacher Education, Rebekah A. Johnson
Building Ai Literacy Through Assessment Practices In Physical Education Teacher Education, Rebekah A. Johnson
Educational Practices in Kinesiology
The classroom resource presented provides an instructional approach designed to enhance both course outcomes and artificial intelligence (AI) literacy in undergraduate physical education preservice teachers. Implemented in a full-semester, in-person Assessment in Physical Education course, the project engaged students in learning to develop effective AI prompts, critically analyze AI-generated outputs, and apply these tools to design a standards-based assessment plan. Designed for undergraduate students with foundational knowledge of assessment and pedagogy, the project incorporated scaffolded tasks, guided discussions, and structured reflections to support AI integration through experiential learning. In approximately 30 minutes per week throughout the semester, students explored how …
"En Papel,” Not In Practice: Indigenous Autonomy And The Structural Barriers To Land And Resource Control In Bolivia, Andrew F. Purcell
"En Papel,” Not In Practice: Indigenous Autonomy And The Structural Barriers To Land And Resource Control In Bolivia, Andrew F. Purcell
Honors Theses
This thesis examines why Bolivia’s 2009 plurinational constitution—despite its strong recognition of Indigenous autonomy, collective territory, and prior consultation—often produces rights that remain “en papel” rather than in practice. Based on one month of fieldwork in Tumupasa, Chojasivi, La Paz, El Alto, and Santa Cruz, the study draws on interviews, participant observation, and NGO documents to analyze the structural barriers that prevent constitutional guarantees from becoming enforceable governance tools. This gap between recognition and implementation structures the central research question: why do Bolivia’s constitutional and legal protections for indigenous land and resource rights function as symbolic guarantees rather than enforceable …
Windows Of Developmental Susceptibility To Tetrahydrocannabivarin (Thcv) Reveal Stage-Dependent Morphological And Biological Effects, Mirielle Clayton
Windows Of Developmental Susceptibility To Tetrahydrocannabivarin (Thcv) Reveal Stage-Dependent Morphological And Biological Effects, Mirielle Clayton
Honors Theses
Tetrahydrocannabivarin (THCV), a minor cannabinoid found in Cannabis sativa, is gaining attention for its potential therapeutic applications, yet its effects on early development remain poorly understood. This study investigated how the timing of THCV exposure influences morphological, behavioral, and bioaccumulation outcomes in zebrafish (Danio rerio) embryos. Embryos were exposed to 2 μM THCV during discrete developmental windows (6–30, 30–54, 54–78, 78–102) and continuous 6–102 hours post-fertilization (hpf), designed to model early stages of human gestation. Behavioral analysis using a larval photomotor response assay revealed significant reductions in locomotor activity during dark phases, with the strongest hypoactivity observed …
Expanding Expanded Access: A Case Of Onc201 And The Ethical Limitations Of Compassionate Use, Ava C. Hutchings
Expanding Expanded Access: A Case Of Onc201 And The Ethical Limitations Of Compassionate Use, Ava C. Hutchings
Honors Theses
This study examines the ethical and structural limitations of the Expanded Access program in the United States, with particular focus on its application to terminal pediatric illness. Although the program is intended to provide patients with life-threatening conditions access to investigational therapies outside of clinical trials, its effectiveness in serving critically ill children remains uncertain. This program is analyzed through careful consideration of regulatory review and ethical theory. Key policies governing Expanded Access are examined alongside scholarly discussions of pediatric autonomy and parental authority.
A case study of ONC201, a now-approved investigational drug, is used to illustrate how Expanded Access …
Values-Based Clinical Ethics: A New Model Of Health And Ethics Consultation For Patients Suffering In Extremis, Adam Trainer
Values-Based Clinical Ethics: A New Model Of Health And Ethics Consultation For Patients Suffering In Extremis, Adam Trainer
Electronic Theses and Dissertations
This dissertation argues that contemporary clinical ethics is inadequately equipped to support patients suffering in extremis because it relies on an insufficiently discriminating account of health and a constrained model of moral reasoning. Drawing on Bernard Lonergan, it reconceives health as an emergent, multi-layered, heuristic notion shaped by biological, psychological, social, and existential goods. On that basis, it critiques principlism’s global applicability thesis and the undergirding claim that its principles form part of the common morality, arguing that this justificatory structure is philosophically insufficient and practically limited for clinical ethics in cases marked by profound suffering, moral plurality, and normative …
Dna Methylation Signatures Associated With Bipolar Disorder In Peripheral Blood Improve Prediction Models, Markos Tesfaye, Anne-Kristin Stavrum, Kira D Höffler, Kevin S O'Connell, Friederike S David, Melanie E Garrett, Sonia Hesam-Shariati, Bronwyn J Overs, Claudia Pisanu, Luana Spano, Oliver J Watkeys, Antoine Weihs, Rafaella Ardau, Allison E Ashley-Koch, Lavinia Athanasiu, Jean C Beckham, Kyle J Bourassa, Caterina Chillotti, Srdjan Djurovic, Ole K Drange, Josef Frank, Anouar Khayachi, Nathan A Kimbrel, Lourdes Martorell, Susanne Meinert, Ingrid Melle, Gunnar Morken, Pasquale Paribello, Marco Pinna, Gloria Roberts, Guy Rouleau, Peter R Schofield, Esteban Sepúlveda, Giovanni Severino, Vidar M Steen, Frederike Stein, Fabian Streit, Va Mid-Atlantic Mirecc Workgroup, Trine Vik Lagerberg, Martin Alda, Udo Dannlowski, Andreas J Forstner, Janice M Fullerton, Hans J Grabe, Melissa J Green, Tilo Kircher, Javier Labad, Mirko Manchia, Philip B Mitchell, Jair C Soares, Alessio Squassina, Alexander Teumer, Leonardo Tondo, Elisabet Vilella, Ole A Andreassen, Boris Chaumette, Gabriel R Fries, Stephanie Le Hellard
Dna Methylation Signatures Associated With Bipolar Disorder In Peripheral Blood Improve Prediction Models, Markos Tesfaye, Anne-Kristin Stavrum, Kira D Höffler, Kevin S O'Connell, Friederike S David, Melanie E Garrett, Sonia Hesam-Shariati, Bronwyn J Overs, Claudia Pisanu, Luana Spano, Oliver J Watkeys, Antoine Weihs, Rafaella Ardau, Allison E Ashley-Koch, Lavinia Athanasiu, Jean C Beckham, Kyle J Bourassa, Caterina Chillotti, Srdjan Djurovic, Ole K Drange, Josef Frank, Anouar Khayachi, Nathan A Kimbrel, Lourdes Martorell, Susanne Meinert, Ingrid Melle, Gunnar Morken, Pasquale Paribello, Marco Pinna, Gloria Roberts, Guy Rouleau, Peter R Schofield, Esteban Sepúlveda, Giovanni Severino, Vidar M Steen, Frederike Stein, Fabian Streit, Va Mid-Atlantic Mirecc Workgroup, Trine Vik Lagerberg, Martin Alda, Udo Dannlowski, Andreas J Forstner, Janice M Fullerton, Hans J Grabe, Melissa J Green, Tilo Kircher, Javier Labad, Mirko Manchia, Philip B Mitchell, Jair C Soares, Alessio Squassina, Alexander Teumer, Leonardo Tondo, Elisabet Vilella, Ole A Andreassen, Boris Chaumette, Gabriel R Fries, Stephanie Le Hellard
Faculty, Staff and Student Publications
Background: Bipolar disorder (BD) is a major mood disorder influenced by both genetic and environmental factors. While DNA methylation from peripheral tissues can reflect both genetic and environmental influences and reveal insights into disease biology, it remains understudied in BD. DNA methylation signatures may complement polygenic scores (PGS) and hold potential as biomarkers. Here, we conducted the largest epigenome-wide association study (EWAS) of BD to date and evaluated the predictive value of polymethylation scores (PMS) in classifying case-control status.
Methods: DNA methylation from peripheral blood of 1729 cases and 1747 controls, comprising twelve cohorts, was obtained. We performed meta-analyses for …
Identifying Novel Gene Dysregulation Associated With Opioid Overdose Death: A Meta-Analysis Of Differential Gene Expression In Human Prefrontal Cortex, Javan K Carter, Bryan C Quach, Caryn Willis, Melyssa S Minto, Dana B Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W Logan, Consuelo Walss-Bass, Brion S Maher, Eric Otto Johnson
Identifying Novel Gene Dysregulation Associated With Opioid Overdose Death: A Meta-Analysis Of Differential Gene Expression In Human Prefrontal Cortex, Javan K Carter, Bryan C Quach, Caryn Willis, Melyssa S Minto, Dana B Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W Logan, Consuelo Walss-Bass, Brion S Maher, Eric Otto Johnson
Faculty, Staff and Student Publications
Only recently have human postmortem brain studies of differential gene expression (DGE) associated with opioid overdose death (OOD) been published; sample sizes from these studies have been modest (N = 40-153). To increase statistical power to identify OOD-associated genes, we leveraged human prefrontal cortex RNA-seq data from four independent OOD studies and conducted a transcriptome-wide DGE meta-analysis (N = 272). Using a unified gene expression data processing and analysis framework across studies, we meta-analyzed 20, 098 genes and found 335 significant differentially expressed genes (DEGs) by OOD status (false discovery rate < 0.05). Of these, 66 DEGs were among the list of 303 genes reported as OOD-associated in prior prefrontal cortex molecular studies (e.g., genes/gene families OPRK1, NPAS4, DUSP, EGR). The remaining 269 DEGs were not previously reported (e.g., NR4A2, SYT1, HCRTR2, BDNF). There was little evidence of genetic drivers for the observed differences in gene expression between opioid addiction cases and controls. Enrichment analyses for the DEGs across molecular pathway and biological process databases highlight an interconnected set of genes and pathways linked to orexin and tyrosine kinase receptors through MEK/ERK/MAPK signaling to affect neuronal plasticity.
Energy Materials Health Monitoring With Interpretable Machine Learning, Osumanu Musah Mohammed
Energy Materials Health Monitoring With Interpretable Machine Learning, Osumanu Musah Mohammed
Honors Theses
Reliability and the lifecycle of energy materials have become key concerns for sustainable, decarbonized power systems [1]. More recent reports on photovoltaic (PV) device technologies, fuel cells, hydrogen storage, and novel composite materials have indicated that material deterioration is a constraint on large-scale exploitation and cost-effectiveness, rather than on energy conversion efficiency [2], [3]. The energy infrastructure of tomorrow needs to be smart and efficient; however, more to the point, it needs to be self-aware, self-diagnostic, and able to overcome any form of degradation before breaking down [4]. The US dilemma is also directly related to federal concerns. That is …
The Effect Of A Superficial Biochar Layer On Soil Radon Exhalation: A Preliminary Investigation Into A Passive Residential Radon Mitigation Strategy, Nicholas Richmond Nelson
The Effect Of A Superficial Biochar Layer On Soil Radon Exhalation: A Preliminary Investigation Into A Passive Residential Radon Mitigation Strategy, Nicholas Richmond Nelson
Honors Theses
Residential radon exposure is a leading cause of lung cancer worldwide, yet home testing and mitigation remain infrequent. Active mitigation systems can be costly, and existing passive radon-resistant construction techniques, while cost-effective, are not always sufficient to reduce indoor radon to below the recommended EPA threshold of 4.0 pCi/L (148 Bq/m3). This initial work examines the potential for a superficial biochar layer placed beneath a house foundation during construction to reduce soil radon exhalation and subsequent indoor radon concentration. Biochar is also being explored as an admixture to concrete, and this study investigates radon transmission through concrete with varying biochar …
Hydrogeochemistry Of Natural Acid Rock Drainage In The Tobacco Root Mountains Of Southwest Montana And Implications For Restoration, Josie Grigsby
Hydrogeochemistry Of Natural Acid Rock Drainage In The Tobacco Root Mountains Of Southwest Montana And Implications For Restoration, Josie Grigsby
Honors Theses
This study investigates the hydrogeochemistry of the East Fork of the South Boulder River (EFSBR) in the northern Tobacco Root Mountains, Madison County, Montana. The upper 5 km of the main stem of the EFSBR is acidic (pH < 5.5), and dissolved concentrations of several trace metals including Al, Cd, Cu, and Zn exceed chronic aquatic life standards by 2-3 orders of magnitude. Unsurprisingly, the EFSBR appears to be devoid of trout. Since no mining has taken place at the source areas of the acidic headwater streams, this phenomenon is referred to as Natural Acid Rock Drainage (NARD). High mountains (up to 10,500’) bounding the EFSBR valley harbor a number of potential small rock glaciers and other periglacial features that appear to influence the hydrogeology and chemistry of the watershed. The steady flow of cold water in the hot summer months, during the same time period that neighboring drainages are drying up, is hypothesized to be sourced from melting ground ice high in the headwater catchment. Additionally, rock glaciers can act as efficient chemical reactors where they exist in conjunction with acid-generating mineralized bedrock, affecting the severity of acidic drainage and associated metal concentrations. Neutralization of the acidic water by alkaline tributaries results in the precipitation of aluminum hydroxysulfate (basaluminite), which covers the streambed with a vivid white mineral coating and can act as a natural sink through adsorption of other toxic metals to its surface. Pristine catchments exhibiting NARD can provide water quality data and serve as reference sites for restoration projects at sites experiencing Acid Mine Drainage where historical data does not exist. As climate change continues to alter the natural environment, especially in polar and high elevation regions, severity and instances of NARD are predicted to continue to increase on a global scale. A deeper understanding of the processes driving NARD from studies focused on areas such as the EFSBR will provide guidance for protecting vulnerable aquatic ecosystems and managing water resources in mountain communities into the future, as well as insights into necessary changes to established remediation methods in watersheds experiencing acid mine drainage.
Optimization And Safety Protocols For An Acetone Production Plant, Holley J. Garrison
Optimization And Safety Protocols For An Acetone Production Plant, Holley J. Garrison
Honors Theses
The proposed acetone production plant, scheduled for start-up in 2028, is capable of producing 3,750 kg/h of 99.9 wt% acetone. Using an endothermic catalytic dehydrogenation reaction, a feed of isopropyl alcohol (IPA) is reacted to produce 30,000 metric tons per year (MT/y) of acetone. Initial design and economic analysis of this process found that this plant will not be economically viable due to its Net Present Value (NPV) of -$132M. Optimization efforts prioritized reductions in raw materials and improved product recovery. Several optimizations were performed to reduce the feed rate, including switching to the low temperature catalyst, shortening the reactor …
Beyond Religious Narcissistic Identification: Agnostic And Atheistic Narcissism, Magdalena Żemojtel-Piotrowska, Jarosław Piotrowski, Bartłomiej Nowak, Vassilis Saroglou, John Maltby, Constantine Sedikides, Mladen Adamovic, Nur Amali Aminnuddin, Seth Christopher Yaw Appiah, Rahkman Ardi, Zana Hasan Babakr, Einar Baldvin Baldursson, Sergiu Bălțătescu, Muhammed Bilgehan Aytaç, Aidos Bolatov, Bruno Bonfá-Araujo, Matthias Burghart, Phatthanakit Chobthamkit, Marilyn Clark, Magali Clobert, Richard G. Cowden, Jesus Alonso Datu, Sandesh Dhakal, Sonya Dragova-Koleva, Begoña Espejo, Dmitry Grigoryev, Emanuela Gritti, Katherine Gundolf
Beyond Religious Narcissistic Identification: Agnostic And Atheistic Narcissism, Magdalena Żemojtel-Piotrowska, Jarosław Piotrowski, Bartłomiej Nowak, Vassilis Saroglou, John Maltby, Constantine Sedikides, Mladen Adamovic, Nur Amali Aminnuddin, Seth Christopher Yaw Appiah, Rahkman Ardi, Zana Hasan Babakr, Einar Baldvin Baldursson, Sergiu Bălțătescu, Muhammed Bilgehan Aytaç, Aidos Bolatov, Bruno Bonfá-Araujo, Matthias Burghart, Phatthanakit Chobthamkit, Marilyn Clark, Magali Clobert, Richard G. Cowden, Jesus Alonso Datu, Sandesh Dhakal, Sonya Dragova-Koleva, Begoña Espejo, Dmitry Grigoryev, Emanuela Gritti, Katherine Gundolf
All Works
Agnosticism and atheism are often grouped simply as nonreligious identities, yet emerging research highlights their distinct psychological profiles and social implications. Among these distinctions, collective narcissism–characterized by strong attachment to one’s group, exceptionalism, and grievance for recognition–offers a framework for understanding identity processes in both nonreligious groups. We examined whether agnostics and atheists exhibit collective narcissism and its forms (agentic–focused on exceptional effectiveness; communal–focused on exceptional morality) similarly to believers. We explored cross-denominational variance in agentic and communal collective narcissism levels relying on data from 77 countries (N = 3,570; 1227 agnostics, 2343 atheists). Agnostics and atheists from secular countries …
Nivolumab Plus Ipilimumab For Chemotherapy-Refractory Metastatic Castration-Resistant Prostate Cancer: Results From The Randomized Portion Of The Phase 2 Checkmate 650 Trial, Padmanee Sharma, Russell K Pachynski, Et Al.
Nivolumab Plus Ipilimumab For Chemotherapy-Refractory Metastatic Castration-Resistant Prostate Cancer: Results From The Randomized Portion Of The Phase 2 Checkmate 650 Trial, Padmanee Sharma, Russell K Pachynski, Et Al.
2020-Current year OA Pubs
We report on the randomized portion of the phase 2, open-label CheckMate 650 trial (NCT02985957), in which docetaxel-experienced, biologically male patients with chemotherapy-refractory metastatic castration-resistant prostate cancer were randomized 2:2:1:2 to nivolumab 3 mg /kg plus ipilimumab 1 mg /kg (n = 73), nivolumab 1 mg /kg plus ipilimumab 3 mg /kg (n = 74), ipilimumab 3 mg /kg (n = 38), or cabazitaxel (n = 74). Primary endpoints were objective response rate and radiographic progression-free survival; key secondary endpoints included overall survival, prostate-specific antigen response rate, and safety. This portion of CheckMate 650 was not designed to statistically compare …
Development Of Novel Plasma Proteomic Biomarkers For Cancer-Associated Thrombosis In An Advanced Cancer Cohort, Preeti, Mrinal Ranjan, Dang Pham, Juan L Bueno, Micheline M Resende, Michael E Scheurer, Christopher I Amos, Chao Cheng, Ang Li
Development Of Novel Plasma Proteomic Biomarkers For Cancer-Associated Thrombosis In An Advanced Cancer Cohort, Preeti, Mrinal Ranjan, Dang Pham, Juan L Bueno, Micheline M Resende, Michael E Scheurer, Christopher I Amos, Chao Cheng, Ang Li
Faculty, Staff and Students Publications
Background: Existing risk models for cancer-associated thrombosis (CAT) show suboptimal performance in selective high-risk populations with cancer. Affinity-based plasma proteomics offers a novel approach for detecting CAT risk.
Objectives: To identify plasma biomarkers for CAT using proximity extension assays in an advanced cancer cohort.
Methods: We performed a nested case-control study using the Olink Explore HT panel. The final cohort included 57 patients with CAT and 113 matched control patients from 5 selected cancer types who had samples collected between cancer diagnosis and chemotherapy initiation. Random survival forest model was used to assess nonlinear associations with CAT in 5416 normalized …