Digital Commons Network^™

Evaluation Of Antibiotic Use In Pediatric Inpatients At One Of Bandung Regional Hospitals In August 2023, Purti Maharani, Imam Wicaksono, Falerina Puspita, Hijrah Zainudin

Pharmacology and Clinical Pharmacy Research

Infectious diseases are a major concern in the field of health, especially in developing countries like Indonesia. Children are vulnerable to infections because their immune systems are not fully developed. Proper management is necessary for the prevention and treatment of infectious diseases in pediatric patients. Antibiotics are the primary choice for addressing bacterial infections. However, the increased use of antibiotic can contribute to high levels of antimicrobial resistance (AMR), rendering infection treatment ineffective. The evaluation of antibiotic use can be conducted through the ATC/DDD method, which focuses on the quantity and types of antibiotics used. Although this method provides a …

Teacher Knowledge And Confidence Integrating Social Change Concepts In K–12 Classrooms, Amy White, Fran Reed, Tina Marshall-Bradley, Kathy Strang

Journal of Sustainable Social Impact

The purpose of this survey research was to examine the perspectives of K–12 classroom teachers about their knowledge of social change concepts and their confidence in implementing these into their existing curriculum. A questionnaire was used to (a) examine the perspectives of K–12 classroom teachers about the knowledge, skills, and resources they need to implement social change concepts into their teaching and (b) define areas of social change that teachers struggle to implement in K–12 classrooms. We employed Wilcoxen signed rank tests to determine if differences existed between what teachers reported they knew and their confidence in integrating 11 social …

Analysis Of Cost-Effectiveness Of Antihypertensive Therapy In Hypertension Patients At Al-Ihsan Regional Public Hospital In 2023, Masyitah Isnaini, Widiah Widiarti, Miski Khairinisa

Pharmacology and Clinical Pharmacy Research

Hypertension is a disease that causes an abnormal increase in blood pressure, which causes cardiovascular disease. Long-term hypertension therapy requires large costs. Apart from that, existing antihypertensives are also very varied, so a cost-effectiveness analysis is needed in order to choose medications that balance costs and advantages. This study aims to determine the most economical antihypertensive medication at Al-Ihsan Regional Public Hospital in Baleendah. Based on patient medical records, this study was carried out retrospectively. Therapy data and treatment costs are the basis for the data collection process. The data is processed descriptively. The reduction in blood pressure that meets …

The Last Resort: Reducing Avoidable Employee Harm By Improving The Application Of The Disciplinary Policy And Process, Andrew Cooper, Kevin Rui-Han Teoh, Ruth Madine, Adrian Neal, Aled Jones, Ammarah Hussain, Doris A. Behrens

School of Nursing and Midwifery

Introduction: There is growing evidence within the healthcare sector that employee investigations can harm individuals involved in the process, an organization’s culture and the delivery of its services.MethodsThis paper details an intervention developed by an NHS Wales organization to reduce the number of its employee investigations through an organization-wide focus that promoted a ‘last resort’ approach and introduced the concept of ‘avoidable employee harm’. A range of associated improvement initiatives were developed to support behavior change among those responsible for determining whether an employee investigation should be initiated.Results: Over a 13-month period, organizational records showed an annual reduction of 71% …

Navigating Global Engineering Education Accreditation: Assessing Ethical Integration And Charting Pathways For Progress, Shannon M. Chance, J Seniuk Cicek, A R Bielefeld, S Hladik, Diana Adela Martin, D M Riley

Research Outputs: 2025-Present

Accreditation in engineering has been widely adopted, enabled by notable harmonization among accrediting bodies worldwide. This alignment, facilitated by accords among nations and regions, fosters a shared understanding of expectations critical for the globalized engineering profession. While ensuring graduates are equipped with essential skills for international collaboration, engineering education grapples with defining and instilling ethics, and the problematic nature of this endeavor is complicated by vague and ambiguous terminology within accreditation documents. Addressing this gap requires navigating power dynamics among education, accreditation, and licensure alongside creating localized, meaningful educational experiences. This paper overviews one section from the forthcoming Routledge International …

Workshop Wine Wednesdays: Improving Knowledge And Motivations About Local Wines., Aude A. Watrelot, Sarah Al-Mazroa Smith, Sarah L. Francis

Journal of Extension

The grape and wine industry in Iowa is based on non-Vitis vinifera grapes, which are not well-known by consumers and come with their own set of challenges, such as promotion. The Wine Wednesdays workshop focused on promoting awareness and knowledge of local wines and grapes. Results indicate gain in self-perceived knowledge and intention of behavior changes toward local grapes and wines. These workshops also participate in the development of relationships among wineries, which is overall beneficial for the local grape and wine industry.

Erratum: Hematologic Dnmt3a Reduction And High-Fat Diet Synergize To Promote Weight Gain And Tissue Inflammation, Angelina S Bortoletto, Carina Rosas, Chun-Wei Chen, Sarah M Waldvogel, Anna G Guzman, Rogelio Aguilar, Sinjini Gupta, Ling Liu, Matthew T Buckley, Kalyani R Patel, Andrea N Marcogliese, Yumei Li, Choladda V Curry, Thomas A Rando, Anne Brunet, Ronald J Parchem, Rachel E Rau, Margaret A Goodell

Faculty, Staff and Students Publications

This corrects the article "Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation", 109122.

Assessing Breast Disease With Deep Learning Model Using Bimodal Bi-View Ultrasound Images And Clinical Information, Tong Ren, Qiao Ji, Yanan Guo, Xiang Li, Yajuan Sui, Xiaohui Xie, Lanqing Han, Yuanqing Li, Yong Ren, Zuofeng Xu

Faculty, Staff and Students Publications

Breast cancer is the second leading cause of carcinoma-linked death in women. We developed a multi-modal deep-learning model (BreNet) to differentiate breast cancer from benign lesions. BreNet was constructed and trained on 10,108 images from one center and tested on 3,762 images from two centers in three steps. The diagnostic ability of BreNet was first compared with that of six radiologists; a BreNet-aided scheme was constructed to improve the diagnostic ability of the radiologists; and the diagnosis of real-world radiologists' scheme was then compared with the BreNet-aided scheme. The diagnostic performance of BreNet was superior to that of the radiologists …

Novel Mutation Leading To Splice Donor Loss In A Conserved Site Of Dmd Gene Causes Duchenne Muscular Dystrophy With Cryptorchidism, Kun Zhang, Hongzheng Dai, Guanglin He, Fuping Li, Li Zeng, Chuanzhu Fan, Huayan Xu

Faculty, Staff and Students Publications

Background: As one of the most common congenital abnormalities in male births, cryptorchidism has been found to have a polygenic aetiology according to previous studies of common variants. However, little is known about genetic predisposition of rare variants for cryptorchidism, since rare variants have larger effective size on diseases than common variants.

Methods: In this study, a cohort of 115 Chinese probands with cryptorchidism was analysed using whole-genome sequencing, alongside 19 parental controls and 2136 unaffected men. Additionally, CRISPR-Cas9 editing of a conserved variant was performed in a mouse model, with MRI screening used to observe the phenotype.

Results: In …

Potential Value Of Brazzein-Yeast As A Broiler Chicken Feed Additive, Lauren Ruth Neuleib

Theses and Dissertations

A variety of flavors, including sweeteners, have been used in animal feeds to improve feed palatability and increase feed intake by livestock (Chen et al., 2020). While many of these sweeteners are found in the form of carbohydrates, brazzein is a sweet-tasting protein. This study was conducted to identify the potential of brazzein to influence feed intake by livestock, using poultry as a model. The preliminary study's purpose was to develop methods appropriate for the subsequent feeding study. In the preliminary study, eight pens of five birds were fed one of four treatment diets: Control or the Control plus one …

Queer Coding And Representation: The Motion Picture Production Code And Its Impact On The Lgbtq Community, Amber Leech

English and Creative Writing Summer Fellows

The Motion Picture Production Code was a set of guidelines for films imposed between 1934 and 1968 that prevented them from depicting immoral themes such as profanity, blasphemy, and glorification of criminal activity. While homosexuality was never explicitly mentioned, it was banned in films through a rule prohibiting the depiction of sex perversion. This resulted in many films using a technique called queer coding in which they could imply that a character was queer without alerting the Production Code Administration. Because queer characters could not be depicted without glamorizing homosexuality, however, many of these characters were villains, died in the …

Pathways Between Early Socioeconomic Deprivation And Alcohol-Related Problems In Emerging Adulthood: Examination Of Environmental And Psychosocial Determinants, Kevin William Campbell

Electronic Theses and Dissertations Archive

The alcohol harm paradox (AHP) has been proposed to account for findings that socioeconomically deprived individuals experience disproportionate rates of alcohol-related harm, despite consuming similar or lower amounts of alcohol relative to more advantaged groups. However, the underlying mechanisms responsible are not well understood. Hogarth proposed the existence of three etiological pathways underpinning the AHP. Emerging adults (EAs) ages 21.5 to 25 (N = 466; Mage = 22.6, 57.5% female, 49.4% White, 38.6% Black, 31.1% non-college EAs), who reported consuming 3/4+ alcoholic drinks (for women/men) at least twice in the past month provided information on childhood family poverty, adverse childhood …

Effort-Reward Imbalance Among Student Athletes: Relationships With Exploitation, Well-Being, Performance Satisfaction, And Burnout, Joseph Michael White

Electronic Theses and Dissertations Archive

College athletics has changed dramatically since the first conception of “sports clubs” centuries ago. The effort required by student-athletes and the rewards they receive for participation have increased in tandem with the money involved in college athletics. Recent changes that allow student-athletes to be paid for use of their name, image, and likeness have further complicated relationships among effort, reward, and outcomes. In the effort-reward imbalance (ERI) model, effort without adequate reward produces stress and poor health-related outcomes, and research has supported this contention with regard to outcomes such as lower well-being and poorer performance among workers. However, few studies …

The Value Of Using Validated Competency-Based Assessments Across The Career Span Of An Athletic Trainer, Matthew Drescher, Lindsey Eberman

Clinical Practice in Athletic Training

No abstract provided.

Perceptions And Use Of The Athletic Training Milestones In Education: A Report From The Aate Research Network, Cailee E. Welch Bacon, Barton E. Anderson, Julie M. Cavallario, Bonnie L. Van Lunen, Lindsey E. Eberman

Clinical Practice in Athletic Training

The Athletic Training Milestones (AT Milestones) were developed as an evaluation tool to capture the breadth and depth of athletic training knowledge, skills, and behavior. However, it is unclear whether athletic training programs are implementing this tool or how they are implementing it to gauge the clinical progression of students or residents in athletic training. We aimed to explore the perceptions and use of the AT Milestones among educators in athletic training programs. We used a cross-sectional, web- based survey with open-ended questions to collect data from athletic training programs on if and how they implement the AT Milestones at …

Standardized Patient Evaluation Tool: A Valid Measure Of The Core Competencies, Lindsey E. Eberman, Jessica Edler Nye

Clinical Practice in Athletic Training

No abstract provided.

The Development, Implementation, And Value Of The Athletic Training Milestones For Assessing Progressive Clinical Behaviors, Hollie Walusz, Eric Sauers, Mark Laursen, Forrest Pecha

Clinical Practice in Athletic Training

No abstract provided.

Nanoscale Mineral Formation At Environmental Interfaces, Ping-I Chou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Water scarcity represents a formidable challenge for human. Exponential population growth and industrial advancements further intensify the demand for potable water. Mineral nucleation at the nanoscale plays a central role in the strategic management of freshwater’s production and quality. In natural groundwater and surface water, the interactions between water and minerals, including earth-abundant iron (hydr)oxides and manganese (Mn) (hydr)oxides, control the mobilization and stabilization of heavy metals, harmful anions, and nutrients, thereby influencing water quality and environmental health. In an engineered context such as membrane desalination, the most widely utilized technique for desalinating seawater, the nucleation and growth of minerals …

Medicaid Coverage As A Critical Component In Care Coordination And Continuity In Health Care Access During Reentry For Justice-Involved Individuals In Maryland, Bernard Bendenkaga Alenda

Walden Dissertations and Doctoral Studies

Incarcerated individuals in the United States have a high disease burden. Moreover, most of them are released from incarceration without health coverage. The problem is that most incarcerated people in Maryland return to the community from incarceration without health coverage and cannot access health care. The purpose of this qualitative study was to understand how Medicaid enrollment staff and managers of the Medicaid program perceive the experiences and challenges of justice-involved individuals in navigating the Medicaid system in Maryland. The study was grounded in the behavioral model for vulnerable populations. The main research question aimed at understanding how the enrollment …

Association Of High Fibrinogen To Albumin Ratio With Long-Term Mortality In Patients With Spontaneous Intracerebral Hemorrhage, Shiping Chen, Yu Zhang, Yangchun Xiao, Xin Cheng, Liyuan Peng, Yixin Tian, Tiangui Li, Jialing He, Pengfei Hao, Weelic Chong, Yang Hai, Chao You, Fang Fang

Department of Medical Oncology Faculty Papers

BACKGROUND: The association between fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in patients with spontaneous intracerebral hemorrhage (ICH) has been established. However, the association with long-term mortality in spontaneous ICH remains unclear. This study aims to investigate the association between FAR and long-term mortality in these patients.

METHODS: Our retrospective study involved 3,538 patients who were diagnosed with ICH at West China Hospital, Sichuan University. All serum fibrinogen and serum albumin samples were collected within 24 h of admission and participants were divided into two groups according to the FAR. We conducted a Cox proportional hazard analysis to evaluate the association …

Trackins (Trk-Targeting Drugs): A Novel Therapy For Different Diseases, George N Chaldakov, Luigi Aloe, Stanislav G Yanev, Marco Fiore, Anton B Tonchev, Manlio Vinciguerra, Nikolai T Evtimov, Peter Ghenev, Krikor Dikranian

2020-Current year OA Pubs

Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases. The following pressing question thus remains: what are the pathogenic routes and how can be they counteracted for therapeutic purposes? Human cells contain >500 protein kinases and nearly 200 protein phosphatases, acting on thousands of proteins, including cell growth factors. We herein discuss neurotrophins with pathogenic or metabotrophic abilities, particularly brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), pro-NGF, neurotrophin-3 (NT-3), and their receptor Trk (tyrosine receptor …

Whole Cervix Imaging Of Collagen, Muscle, And Cellularity In Term And Preterm Pregnancy, Wenjie Wu, Zhexian Sun, Hansong Gao, Yuan Nan, Stephanie Pizzella, Haonan Xu, Josephine Lau, Yiqi Lin, Hui Wang, Pamela K Woodard, Hannah R Krigman, Qing Wang, Yong Wang

2020-Current year OA Pubs

Cervical softening and dilation are critical for the successful term delivery of a fetus, with premature changes associated with preterm birth. Traditional clinical measures like transvaginal ultrasound and Bishop scores fall short in predicting preterm births and elucidating the cervix's complex microstructural changes. Here, we introduce a magnetic resonance diffusion basis spectrum imaging (DBSI) technique for non-invasive, comprehensive imaging of cervical cellularity, collagen, and muscle fibers. This method is validated through ex vivo DBSI and histological analyses of specimens from total hysterectomies. Subsequently, retrospective in vivo DBSI analysis at 32 weeks of gestation in ten term deliveries and seven preterm …

Reality Capture Technologies For Continuous Inline Quality Monitoring In Construction 3d Printing, Michael J. Martin Ii

LSU Master's Theses

Extrusion-based construction 3D printing (C3DP) is an innovative and emerging technology aiming at the modernization of the construction industry. It uses robots and computer control to reduce the need for human labor and to decrease construction time and cost. C3DP creates elements layer by layer without using formworks, and it is critical to detect layer defects and deformations to ensure that each layer is printed with the desired dimensions. These defects can lead to a variety of issues during or after the construction process, including the collapse of freshly printed elements. In order to detect such deformations and to enable …

Bayesian Sequential Monitoring Strategies For Trials Of Digestive Cancer Therapeutics, Guillaume Mulier, Ruitao Lin, Thomas Aparicio, Lucie Biard

Faculty, Staff and Student Publications

Background: New therapeutics in oncology have presented challenges to existing paradigms and trial designs in all phases of drug development. As a motivating example, we considered an ongoing phase II trial planned to evaluate the combination of a MET inhibitor and an anti-PD-L1 immunotherapy to treat advanced oesogastric carcinoma. The objective of the paper was to exemplify the planning of an adaptive phase II trial with novel anti-cancer agents, including prolonged observation windows and joint sequential evaluation of efficacy and toxicity.

Methods: We considered various candidate designs and computed decision rules assuming correlations between efficacy and toxicity. Simulations were conducted …

Safety And Effectiveness Of Using Disposable Ultrasonic Shears To Coagulate 5–7 Mm Blood Vessels: Protocol For A Prospective, Multicenter, Randomized, Parallel Controlled, Non-Inferiority Clinical Trial, Xipeng Wang, Chengqiang Li, Junqiang Fan, Jian Hu, Mingsong Wang

Faculty, Staff and Student Publications

BACKGROUND: The ultrasonic scalpel is widely used during surgery. It is safe and effective to close the pulmonary artery branch vessels of 7 mm or below with an ultrasonic energy device as reported. However, there have been no multicenter randomized clinical trial to assess the safety and effectiveness of using ultrasonic scalpel to coagulate 5-7 mm blood vessels in thoracic surgery.

METHODS: This is a prospective, multicenter, randomized, parallel controlled, non-inferiority clinical trial. A total of 144 eligible patients planning to undergo lung or esophageal surgery will be randomly allocated to the experimental group and the control group. The investigational …

Exploration Of A Potential Door Endpoint For Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia Using Six Registrational Trials For Antibacterial Drugs, Tori Kinamon, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Scott R Evans, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Sumati Nambiar, Peter Kim, Helen W Boucher, Ramya Gopinath

Faculty, Staff and Student Publications

BACKGROUND: Desirability of outcome ranking (DOOR) is an innovative approach to clinical trial design and analysis that uses an ordinal ranking system to incorporate the overall risks and benefits of a therapeutic intervention into a single measurement. Here we derived and evaluated a disease-specific DOOR endpoint for registrational trials for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).

METHODS: Through comprehensive examination of data from nearly 4000 participants enrolled in six registrational trials for HABP/VABP submitted to the Food and Drug Administration (FDA) between 2005 and 2022, we derived and applied a HABP/VABP specific endpoint. We estimated the probability that …

Targeted Co-Expression Networks For The Study Of Traits, A Gómez-Pascual, G Rocamora-Pérez, L Ibanez, J A Botía

2020-Current year OA Pubs

Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used approach for the generation of gene co-expression networks. However, networks generated with this tool usually create large modules with a large set of functional annotations hard to decipher. We have developed TGCN, a new method to create Targeted Gene Co-expression Networks. This method identifies the transcripts that best predict the trait of interest based on gene expression using a refinement of the LASSO regression. Then, it builds the co-expression modules around those transcripts. Algorithm properties were characterized using the expression of 13 brain regions from the Genotype-Tissue Expression project. When …

Instrumental Variable And Colocalization Analyses Identify Endotrophin And Htra1 As Potential Therapeutic Targets For Coronary Artery Disease, Paul C Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H Burks, Junedh Amrute, Jared S Elenbaas, Chul Joo Kang, Erica P Young, Philipp E Scherer, Nathan O Stitziel

2020-Current year OA Pubs

Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic targets for human disease by nominating causal genes in genome-wide association study (GWAS) loci. We conducted cis-IV analyses for 20,125 genes and 1,746 plasma proteins with CAD using molecular trait quantitative trait loci variant (QTLs) data from three different studies. 19 proteins and 119 genes were significantly associated with CAD risk by IV analyses and demonstrated evidence of genetic colocalization. Notably, our analyses validated well-established targets …

The Relationship Between Mental Health, Self And Other Stigma, And Help-Seeking Behaviors In Ethnic Minority Undergraduate Students, Briane Souki

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Racial and ethnic minority undergraduate students are disproportionately affected by mental health challenges and are less likely to seek support due to self-stigma and stigma from others, cultural perceptions of mental health, and help-seeking behaviors (Tucker et al., 2013). It is critical to understand mental health in cultural contexts because they influence help seeking behaviors for ethnic minority college students. These stigmas are thoughts that influence the help-seeking behaviors of students. Many ethnic minority students have internalized self-stigma toward help seeking. Part of overcoming minority student hesitancy toward help-seeking is to promote culturally aware mental health practices. In predominantly white …

Divine Retribution, Anna Payne

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Sexual abuse has always been an issue in all cultures throughout the world and history. Easton et al. delved into the problems of barriers to disclosing child sexual abuse with 460 male participants which showed that 61.7% of them reported CSA at the hands of a priest. As that study was conducted, Helsel and McCormack tackled the effects of CSA on the nervous system and psyche. While religion is used as a coping mechanism, it is also a tool for maltreatment from clergy sexually abusing children to parents seeking ways to rid the child of demons. There have been over …