Digital Commons Network^™

Association Of High Fibrinogen To Albumin Ratio With Long-Term Mortality In Patients With Spontaneous Intracerebral Hemorrhage, Shiping Chen, Yu Zhang, Yangchun Xiao, Xin Cheng, Liyuan Peng, Yixin Tian, Tiangui Li, Jialing He, Pengfei Hao, Weelic Chong, Yang Hai, Chao You, Fang Fang

Department of Medical Oncology Faculty Papers

BACKGROUND: The association between fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in patients with spontaneous intracerebral hemorrhage (ICH) has been established. However, the association with long-term mortality in spontaneous ICH remains unclear. This study aims to investigate the association between FAR and long-term mortality in these patients.

METHODS: Our retrospective study involved 3,538 patients who were diagnosed with ICH at West China Hospital, Sichuan University. All serum fibrinogen and serum albumin samples were collected within 24 h of admission and participants were divided into two groups according to the FAR. We conducted a Cox proportional hazard analysis to evaluate the association …

Instrumental Variable And Colocalization Analyses Identify Endotrophin And Htra1 As Potential Therapeutic Targets For Coronary Artery Disease, Paul C Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H Burks, Junedh Amrute, Jared S Elenbaas, Chul Joo Kang, Erica P Young, Philipp E Scherer, Nathan O Stitziel

2020-Current year OA Pubs

Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic targets for human disease by nominating causal genes in genome-wide association study (GWAS) loci. We conducted cis-IV analyses for 20,125 genes and 1,746 plasma proteins with CAD using molecular trait quantitative trait loci variant (QTLs) data from three different studies. 19 proteins and 119 genes were significantly associated with CAD risk by IV analyses and demonstrated evidence of genetic colocalization. Notably, our analyses validated well-established targets …

Trackins (Trk-Targeting Drugs): A Novel Therapy For Different Diseases, George N Chaldakov, Luigi Aloe, Stanislav G Yanev, Marco Fiore, Anton B Tonchev, Manlio Vinciguerra, Nikolai T Evtimov, Peter Ghenev, Krikor Dikranian

2020-Current year OA Pubs

Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases. The following pressing question thus remains: what are the pathogenic routes and how can be they counteracted for therapeutic purposes? Human cells contain >500 protein kinases and nearly 200 protein phosphatases, acting on thousands of proteins, including cell growth factors. We herein discuss neurotrophins with pathogenic or metabotrophic abilities, particularly brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), pro-NGF, neurotrophin-3 (NT-3), and their receptor Trk (tyrosine receptor …

Whole Cervix Imaging Of Collagen, Muscle, And Cellularity In Term And Preterm Pregnancy, Wenjie Wu, Zhexian Sun, Hansong Gao, Yuan Nan, Stephanie Pizzella, Haonan Xu, Josephine Lau, Yiqi Lin, Hui Wang, Pamela K Woodard, Hannah R Krigman, Qing Wang, Yong Wang

2020-Current year OA Pubs

Cervical softening and dilation are critical for the successful term delivery of a fetus, with premature changes associated with preterm birth. Traditional clinical measures like transvaginal ultrasound and Bishop scores fall short in predicting preterm births and elucidating the cervix's complex microstructural changes. Here, we introduce a magnetic resonance diffusion basis spectrum imaging (DBSI) technique for non-invasive, comprehensive imaging of cervical cellularity, collagen, and muscle fibers. This method is validated through ex vivo DBSI and histological analyses of specimens from total hysterectomies. Subsequently, retrospective in vivo DBSI analysis at 32 weeks of gestation in ten term deliveries and seven preterm …

Targeted Co-Expression Networks For The Study Of Traits, A Gómez-Pascual, G Rocamora-Pérez, L Ibanez, J A Botía

2020-Current year OA Pubs

Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used approach for the generation of gene co-expression networks. However, networks generated with this tool usually create large modules with a large set of functional annotations hard to decipher. We have developed TGCN, a new method to create Targeted Gene Co-expression Networks. This method identifies the transcripts that best predict the trait of interest based on gene expression using a refinement of the LASSO regression. Then, it builds the co-expression modules around those transcripts. Algorithm properties were characterized using the expression of 13 brain regions from the Genotype-Tissue Expression project. When …

Reality Capture Technologies For Continuous Inline Quality Monitoring In Construction 3d Printing, Michael J. Martin Ii

LSU Master's Theses

Extrusion-based construction 3D printing (C3DP) is an innovative and emerging technology aiming at the modernization of the construction industry. It uses robots and computer control to reduce the need for human labor and to decrease construction time and cost. C3DP creates elements layer by layer without using formworks, and it is critical to detect layer defects and deformations to ensure that each layer is printed with the desired dimensions. These defects can lead to a variety of issues during or after the construction process, including the collapse of freshly printed elements. In order to detect such deformations and to enable …

Bayesian Sequential Monitoring Strategies For Trials Of Digestive Cancer Therapeutics, Guillaume Mulier, Ruitao Lin, Thomas Aparicio, Lucie Biard

Faculty, Staff and Student Publications

Background: New therapeutics in oncology have presented challenges to existing paradigms and trial designs in all phases of drug development. As a motivating example, we considered an ongoing phase II trial planned to evaluate the combination of a MET inhibitor and an anti-PD-L1 immunotherapy to treat advanced oesogastric carcinoma. The objective of the paper was to exemplify the planning of an adaptive phase II trial with novel anti-cancer agents, including prolonged observation windows and joint sequential evaluation of efficacy and toxicity.

Methods: We considered various candidate designs and computed decision rules assuming correlations between efficacy and toxicity. Simulations were conducted …

Safety And Effectiveness Of Using Disposable Ultrasonic Shears To Coagulate 5–7 Mm Blood Vessels: Protocol For A Prospective, Multicenter, Randomized, Parallel Controlled, Non-Inferiority Clinical Trial, Xipeng Wang, Chengqiang Li, Junqiang Fan, Jian Hu, Mingsong Wang

Faculty, Staff and Student Publications

BACKGROUND: The ultrasonic scalpel is widely used during surgery. It is safe and effective to close the pulmonary artery branch vessels of 7 mm or below with an ultrasonic energy device as reported. However, there have been no multicenter randomized clinical trial to assess the safety and effectiveness of using ultrasonic scalpel to coagulate 5-7 mm blood vessels in thoracic surgery.

METHODS: This is a prospective, multicenter, randomized, parallel controlled, non-inferiority clinical trial. A total of 144 eligible patients planning to undergo lung or esophageal surgery will be randomly allocated to the experimental group and the control group. The investigational …

Exploration Of A Potential Door Endpoint For Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia Using Six Registrational Trials For Antibacterial Drugs, Tori Kinamon, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Scott R Evans, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Sumati Nambiar, Peter Kim, Helen W Boucher, Ramya Gopinath

Faculty, Staff and Student Publications

BACKGROUND: Desirability of outcome ranking (DOOR) is an innovative approach to clinical trial design and analysis that uses an ordinal ranking system to incorporate the overall risks and benefits of a therapeutic intervention into a single measurement. Here we derived and evaluated a disease-specific DOOR endpoint for registrational trials for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).

METHODS: Through comprehensive examination of data from nearly 4000 participants enrolled in six registrational trials for HABP/VABP submitted to the Food and Drug Administration (FDA) between 2005 and 2022, we derived and applied a HABP/VABP specific endpoint. We estimated the probability that …

The Relationship Between Mental Health, Self And Other Stigma, And Help-Seeking Behaviors In Ethnic Minority Undergraduate Students, Briane Souki

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Racial and ethnic minority undergraduate students are disproportionately affected by mental health challenges and are less likely to seek support due to self-stigma and stigma from others, cultural perceptions of mental health, and help-seeking behaviors (Tucker et al., 2013). It is critical to understand mental health in cultural contexts because they influence help seeking behaviors for ethnic minority college students. These stigmas are thoughts that influence the help-seeking behaviors of students. Many ethnic minority students have internalized self-stigma toward help seeking. Part of overcoming minority student hesitancy toward help-seeking is to promote culturally aware mental health practices. In predominantly white …

Divine Retribution, Anna Payne

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Sexual abuse has always been an issue in all cultures throughout the world and history. Easton et al. delved into the problems of barriers to disclosing child sexual abuse with 460 male participants which showed that 61.7% of them reported CSA at the hands of a priest. As that study was conducted, Helsel and McCormack tackled the effects of CSA on the nervous system and psyche. While religion is used as a coping mechanism, it is also a tool for maltreatment from clergy sexually abusing children to parents seeking ways to rid the child of demons. There have been over …

Effects Of Emotional Intelligence And Social Support On The Relationship Between Childhood Maltreatment And Disordered Eating, Rachel E. Kilby

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Current research has established a connection between childhood maltreatment and eating disorders, and some studies have looked at emotional intelligence or social support as mediators of this connection. However, little research has looked at how emotional intelligence and social support work together in the relationship between childhood maltreatment and eating disorders. This study looked at how emotional intelligence and social support act as mediators in this relationship. Undergraduate students (N=134) were administered the Childhood Trauma Questionnaire (CTQ-90), Wong-Law Emotional Intelligence Scale (WLEIS), Difficulties in Emotion Regulation Scale (DERS), Perceived Social Support Scale (PSSS), and the Eating Attitudes Test (EAT-26). Correlations …

Students’ Knowledge And Attitude Towards Plagiarism: A Case Of Lusaka Apex Medical University Students, Dalitso Mvula, Treasure Chisakula

Library Philosophy and Practice (e-journal)

Laws guide societies in the world. These laws are meant to create an environment that ensures citizens’ rights are respected. The same happens in academia. There are guidelines that students follow in the execution of their assignments, examinations and research in higher institutions. These guidelines are meant to ensure that there is no any form of academic dishonesty being perpetuated by the students. This paper investigated Lusaka Apex Medical University students’ knowledge and attitude towards plagiarism. The study sought to assess the knowledge of LAMU students towards plagiarism, examine the attitude of LAMU students towards plagiarism, assess factors that foster …

An Investigation Into The Consumption Of Caffeinated Energy Drinks Among University Students In Ireland, Jessica Holmes, Denas Molotokas, Ralfas Molotokas

International Undergraduate Journal of Health Sciences

Objectives: To investigate the consumption patterns of caffeinated energy drinks among university students in the south of Ireland

Materials and Methods: An online survey was created using Google Forms to investigate the consumption of caffeinated energy drinks among university students in Ireland. It was distributed to students via social media and email from the 8th of March to the 21st of March 2023 inclusive. A total of 281 responses were analysed and validated by data cleaning on Microsoft Excel, with 10 incomplete responses discarded, yielding 271 validated responses for statistical analysis.

Results: The majority of survey respondents (71.3%) reported consuming …

A Review Of The Role Of Single-Cell Rna-Sequencing (Scrna-Seq) In The Transcriptome Analysis Of Ductal Carcinoma In Situ (Dcis), Ali Maeve Fitzgerald, Francesca Tiso, Eldar T. Abdullaev, Kirsten Kübler

International Undergraduate Journal of Health Sciences

Ductal carcinoma in situ (DCIS) remains one of the most reported lesions detected by mammography screening programmes, yet our understanding of its progression to malignancy and markers of invasiveness is limited. Although a non-obligate precursor of invasive ductal carcinoma (IDC), all currently diagnosed DCIS patients are indiscriminately subjected to mastectomy or breast-conserving therapy (BCT) and radiotherapy. With less than 50% of untreated DCIS progressing to IDC, questions have been raised surrounding the over-treatment of indolent DCIS.

Thus, one of the central clinical challenges is to assess the risk of disease progression, which has prompted research efforts aimed at refining prognostic …

An Investigation Into Aetiology, Detection And Treatment Of Neonatal Alloimmune Thrombocytopenia, Mairead Horan

International Undergraduate Journal of Health Sciences

NAIT is a rare disorder with a similar aetiology to HDN, however unlike its erythrocyte counterpart, thrombocyte immunisation can occur within the first pregnancy. (Giouleka et al., 2023). The most common antibodies implicated are HLA-1a. (Winkelhorst et al., 2017). 2.5% of the Caucasian population are HPA-1a negative, of this population 33% are HLA-DR-B3*0101 positive increasing the risk of producing an alloantibody upon encountering the HPA-1a antigen. The maternal system becomes alloimmunised to the foreign paternal antigens of the foetus/neonate, which cross the placenta causing low platelets of the foetus. (Giouleka et al., 2023).

A third of antigen-positive neonates born to …

Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 4, Issue 1, July 2024, Iujhs Full Issue

International Undergraduate Journal of Health Sciences

Full Issue: The International Undergraduate Journal of Health Sciences, Volume 4, Issue 1, July 2024

Memetic Memory As Vital Conduits Of Troublemakers In Digital Culture, Alexander O. Smith, Jordan Loewen-Colón

School of Information Studies - Post-doc and Student Scholarship

Recent fears of data capitalism and colonialism often argue using implicit assumptions about cybernetic technology’s ability to automate data about culture. As such, the level of data granularity made possible by cybernetic engineering can be used to dominate society and culture. Here we unpack these implicit assumptions about the datafication of culture through memes, which both act as cultural data and cultural memory. Using Alexander Galloway’s critical method of protocological analysis and descriptions of media tactics, we respond to fears of cybernetic domination. Protocols – the source by which cybernetic technologies enable automated datafication – enables us to respond to …

Vol.51 N.52 July 18th 2024, Voice Media Ventures

Black Voice News

No abstract provided.

Medical School Watercooler Newsletter - July 18, 2024, Lindsay Hughes

Watercooler Newsletter

This is the July 18, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• Medical student presents diagnostic radiology research at conference in Singapore
• Summer Research Day set for July 26
• USA welcomes new anatomic and clinical pathologist

Disasters And Disorganization: The Flood Of 2022 In Eastern Kentucky And The Struggles That Linger, Justin Hutchens

Online Theses and Dissertations

In July of 2022, a generational flood washed out many small communities across 13 Kentucky counties in Central Appalachia. This disaster, like previous disasters, uncovered structural and socioeconomic issues perpetuated by those in power that were hidden from the outside world. Minimal news coverage of the flood damage created the impression that aid has been substantial, and towns have been rebuilt. This ethnographic research, carried out in 2023 in Letcher County, reveals extensive damage and long-term consequences for the region. Through a series of interviews with residents of the county, this paper examines the disaster, the structural context in which …

A Systematic Review Of Trauma-Informed Care In Applied Behavior Analysis, Staci Archibald

Theses

Although the use of trauma-informed care (TIC) has been featured in the delivery of different human services fields, its integration in applied behavior analysis (ABA) is scarce. The purpose of this research was to determine how many empirical studies include both principles of behavior analysis as well as TIC. The findings imply that, while research in this area is very limited, including TIC in ABA may improve treatment outcomes, particularly for people with complicated trauma histories and many restrictive measures. This review revealed a significant literature gap regarding specific frameworks and guidelines for effectively integrating TIC into ABA practices. Addressing …

Occupational Therapy's Role In Maternal, Infant, And Family Wellness: Policy, Procedure, And Program Development, Emilee Armstrong

Department of Occupational Therapy Entry-Level Capstone Projects

This capstone project aimed to advocate for maternal, infant, and family wellness through occupational therapy services. The focus areas of my capstone project included administration, advocacy, policy and program development. I developed two post-cesarean delivery policies for maternal rehabilitation and father-infant bonding, a Kangaroo Father Care program, and an occupational therapy position proposal. The Kangaroo Father Care program included healthcare professional educational modules, an administration checklist, and facility and patient flyers. My project aimed to develop the foundation for implementing acute maternal rehabilitative services for a regional hospital in Northeast Indiana. The knowledge and skills I gained throughout my capstone …

Profiles Of Two Determined First-Year Medical School Students, July 18, 2024, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

Unh Researcher Develops Model For More Equitable Welfare Fund Distribution, Robbin Ray

Media Relations

No abstract provided.

Teaching Humanizing Language In Legal Writing Classrooms: Fostering Empathy And Inclusion, Amanda K. Stephen

Presentations

No abstract provided.

The Minutes Of The Marshall University Staff Council Meeting, July 2024, Marshall University Staff Council

Staff Council Minutes

No abstract provided.

Seguir Adelante: A Qualitative Exploration Of Latino Farmworkers' Work And Non-Work Resources, Faviola Robles Saenz

Dissertations and Theses

Precarious work sectors within the United States have relied on Black and Brown labor for many decades. More specifically, Latino immigrant workers have been an exploited community within many dangerous workforces but especially within the agricultural industry. They are a crucial population for the labor and economy of the U.S., yet Latino farmworkers report feeling expendable, being discriminated against, and being exposed to hazardous working conditions. Due to these experiences, scholars have explored the role non-work resources have in providing support for this community, their social networks being especially beneficial for them. However, research on the links between their work …

Analyzing The Legitimacy, Effectiveness, And Legacy Of The United Nations, Hunter Wade Calley

Dissertations and Theses

This thesis examines the legitimacy and effectiveness of the United Nations since its establishment, while also exploring the shortcomings of its predecessor, the League of Nations. The legitimacy of the United Nations and the role the organization plays in the world of international politics, the flaws of the UN Security Council, and the impact of the Cold War on the legitimacy and processes of the United Nations are especially highlighted throughout this thesis.

The successes and shortcomings of the United Nations are best understood given the historical context of the League of Nations, the organization founded to bring world powers …

Implementing Interdisciplinary Sustainability Education With The Food-Energy-Water (Few) Nexus, Chelsie Romulo, Bhawani Venkataraman, Susan Caplow, Shamili Ajgaonkar, Craig R. Allen, Aavudai Anandhi, Steven W. Anderson, Caterina Belle Azzarello, Katja Brundiers, Eunice Blavascunas, Jenny M. Dauer, Daniel L. Druckenbrod, Ennea Fairchild, Lydia R. Horne, Kyungsun Lee, Marizvkuru Mwale, John Mischler, Emily Pappo, Nirav S. Patel, Nicole D. Sintov, Carla S. Ramsdell, Shirley G. Vincent

GGS Faculty Publications

Growth in the green jobs sector has increased demand for college graduates who are prepared to enter the workforce with interdisciplinary sustainability skills. Simultaneously, scholarly calls for interdisciplinary collaboration in the service of addressing the societal challenges of enhancing resilience and sustainability have also increased in recent years. However, developing, executing, and assessing interdisciplinary content and skills at the post-secondary level has been challenging. The objective of this paper is to offer the Food-Energy-Water (FEW) Nexus as a powerful way to achieve sustainability competencies and matriculate graduates who will be equipped to facilitate the transformation of the global society by …