Digital Commons Network^™

Increasing Access To Non-Dairy Beverages And Commercial Thickeners, Kathleen Carr

General Submissions: Presentations (Oral and Poster)

The primary aim of the project was to identify whether financial assistance in the form of product vouchers for non-dairy (later expanded to include dairy) or commercially available thickeners impacts the time from initial recommendation to identification of a tolerated product. A secondary aim included identifying whether financial assistance in the form of product vouchers for non-dairy (later expanded to include dairy) beverages or commercially available thickeners impacts insurance coverage.

Sunlight Solutions: Optimizing 25(Oh)D Concentrations In Global Maternal Health Strategies To Improve Maternal Outcomes And Preserve Healthcare Resources, Beth Sanford

Global Advocacy

In 2020, the World Health Organization identified the Global maternal mortality rate was a staggering 223 per 100,000. As a result, the United Nations created Sustainable Development Goal 3.1, with the hope of "reducing the global MMR to less than 70 per 100 000 births, with no country having a maternal mortality rate of more than twice the global average" by 2030.

Optimizing 25(OH)D serum concentrations to a minimum of 40 ng/mL (100 nmol/L) has been proven to be a safe, affordable, and effective way to improve perinatal outcomes such as decreasing maternal mortality as well as morbidities such as …

Climate Challenge For Sigma Chapters, Kathy Burlingame, Michelle Dephillips, Michelle Gilbert, Kelly Kuhns, Daria Waszak

Global Advocacy

There are a plethora of health effects connected to climate change's impacts on weather, food, water, air, heat, vectors, allergens, and more. As a trusted voice, nurses are in an opportune position to advocate for climate action and its related impacts on health. Whilst, the topic of climate change should be integrated more consistently through curricula for nurses. With that in mind, The Nurses Climate Challenge, a campaign of the ANHE and Healthcare Without Harm, was launched in 2018. Its initial aim of engaging 50,000 nurses was met, and the initiative is being transferred to ANHE this month.

Foster Parents Assisting Transitioning Foster Care Youth In Maintaining Stable Housing, Cecilann Morrison

Walden Dissertations and Doctoral Studies

Foster Parents Assisting Transitioning Foster Care Youth in Maintaining Stable Housing by Cecilann Morrison MA, National University, 2013 BS, Fresno Pacific University, 2011 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Human and Social Service Walden University June 2024

Strategies For Evaluating Training For Field Engineers In The Aerospace And Defense Industry, Nathan D. Johnson

Walden Dissertations and Doctoral Studies

Inefficient training strategies are just one of the many challenges field engineer managers face in the aerospace and defense industry. Aerospace and defense managers and customers are concerned because inefficient training strategies for field engineers impact how well they can effectively contribute to organizational and customer mission success in operations around the globe. Grounded in the Kirkpatrick model, the purpose of this qualitative pragmatic inquiry was to explore strategies aerospace and defense managers use to evaluate field engineer training programs. The participants were five aerospace and defense managers who successfully implemented training evaluation strategies. Data were collected from semistructured interviews …

Porphyrin Overdrive In Cancer: Unraveling The Mechanisms And Therapeutic Potential, Pravin D. Meshram

USF Tampa Graduate Theses and Dissertations

The increased understanding of cancer cell metabolism has shown options for novel treatment strategies. This thesis looks at the role of heme metabolism, specifically "porphyrin overdrive," in cancer progression and treatment. Cancer cells are hypermetabolic and rely on heme synthesis. When treated with δ-aminolevulinic acid (ALA), they abnormally accumulate heme intermediates. This metabolic weakness presents an opportunity to exploit heme synthesis in targeted cancer therapy. In this study, we suggest a "Bait and Kill" technique that uses exogenous ALA to induce protoporphyrin IX (PpIX) buildup in cancer cells, making them more susceptible to oxidative stress. We investigate the possibility of …

Car T-Cell Expansion: Harmful Or Helpful?, Anath C Lionel, Sattva S Neelapu

Faculty, Staff and Student Publications

No abstract provided.

Hypoxia Inducible Factor 2Α Promotes Tolerogenic Macrophage Development During Cardiac Transplantation Through Transcriptional Regulation Of Colony Stimulating Factor 1 Receptor, Matthew Deberge, Samantha Schroth, Fanfan Du, Xin Yi Yeap, Jiao-Jing Wang, Zheng Jenny Zhang, Mohammed Javeed Ansari, Evan A Scott, Edward B Thorp

Faculty, Staff and Student Publications

Solid organ transplantation mobilizes myeloid cells, including monocytes and macrophages, which are central protagonists of allograft rejection. However, myeloid cells can also be functionally reprogrammed by perioperative costimulatory blockade to promote a state of transplantation tolerance. Transplantation tolerance holds promise to reduce complications from chronic immunosuppression and promote long-term survival in transplant recipients. We sought to identify different mediators of transplantation tolerance by performing single-cell RNA sequencing of acute rejecting or tolerized cardiac allografts. This led to the unbiased identification of the transcription factor, hypoxia inducible factor (HIF)-2α, in a subset of tolerogenic monocytes. Using flow cytometric analyses and mice …

Cracd Loss Induces Neuroendocrine Cell Plasticity Of Lung Adenocarcinoma, Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park

Faculty, Staff and Student Publications

Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, some lung adenocarcinoma (LUAD) cells transform into neuroendocrine (NE) tumor cells. However, the mechanisms of NE cell plasticity remain unclear. CRACD (capping protein inhibiting regulator of actin dynamics), a capping protein inhibitor, is frequently inactivated in cancers. CRACD knockout (KO) is sufficient to de-repress NE-related gene expression in the pulmonary epithelium and LUAD cells. In LUAD mouse models, Cracd KO increases intratumoral heterogeneity with NE gene expression. Single-cell transcriptomic analysis showed that Cracd KO-induced NE cell plasticity is associated with cell de-differentiation and stemness-related pathway activation. The …

A Spatiotemporal Map Of Co-Receptor Signaling Networks Underlying B Cell Activation, Katherine J Susa, Gary A Bradshaw, Robyn J Eisert, Charlotte M Schilling, Marian Kalocsay, Stephen C Blacklow, Andrew C Kruse

Faculty, Staff and Student Publications

The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. Here, we take advantage of peroxidase-catalyzed proximity labeling combined with quantitative mass spectrometry to track co-receptor signaling dynamics in Raji cells from 10 s to 2 h after BCR stimulation. This approach enables tracking of 2,814 proximity-labeled proteins and 1,394 phosphosites and provides an unbiased and quantitative molecular map of proteins recruited to the vicinity of CD19, the signaling subunit of the co-receptor complex. We detail the recruitment kinetics of signaling effectors to CD19 and identify previously uncharacterized …

Molecular Docking Of The Interaction Between Citrus Amblycarpa Extract Contents And Inflammatory Proteins Of Hepatic Steatosis, Lena Rosida, Dewi Indah Noviana Pratiwi, Roselina Panghiyangani, Juliyatin Putri Utami, Nasrul Idhafi, Muhammad Febriansyah, Andi Azizah Maulidia Budiarman

Makara Journal of Science

Citrus amblycarpa possesses various pharmacological activities, such as antioxidant, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. The main active compounds in C. amblycarpa (including gamma (γ)-aminobutyric acid [GABA], hesperidin, naringin, neoeriocitrin, poncirin, quercetin, and rutin) show potential to interact with the inflammatory proteins in hepatic steatosis (such as nuclear factor kappa beta [NF-kB], tumor necrosis alpha [TNF-alpha], interleukin-6 [IL-6], c-Jun NH2-terminal kinase [JNK], and adiponectin). Molecular docking simulations were performed using Swiss Dock (http://www.swissdock.ch/), and analysis and visualization were conducted using Discovery Studio 4.1. Rutin, poncirin, hesperidin, and neoeriocitrin exhibit high affinities to NF-κB, TNF-alpha, IL-6, and adiponectin …

Coordinated Population Forecast For Multnomah County, Its Urban Growth Boundaries (Ugb), And Area Outside Ugbs 2024-2074, Neal Marquez, Ethan Sharygin, Suniva Thangaraj, Huda Alkitkat, Gilbert Montcho, David Swanson, Joshua Wilde

Oregon Population Forecast Program

This report for population forecasts for Multnomah County was made in compliance with Oregon House Bill 2253 relating to population forecasts for land use planning. Portland State University Population Research Center is tasked with creating population projections for all Oregon counties except Multnomah, Clackamas, and Washington as well as population forecasts for all Urban Growth Boundaries (UGBs), except for the Metro area UGB. These population forecasts are generated using standardized demographic methods with input and feedback from county, city, and other local stakeholders.

Coordinated Population Forecast For Hood River County, Its Urban Growth Boundaries (Ugb), And Area Outside Ugbs 2024-2074, Neal Marquez, Ethan Sharygin, Huda Alkitkat, Suniva Thangaraj, Gilbert Montcho, David Swanson, Joshua Wilde

Oregon Population Forecast Program

This report for population forecasts for Columbia County was made in compliance with Oregon House Bill 2253 relating to population forecasts for land use planning. Portland State University Population Research Center is tasked with creating population projections for all Oregon counties except Multnomah, Clackamas, and Washington as well as population forecasts for all Urban Growth Boundaries (UGBs), except for the Metro area UGB. These population forecasts are generated using standardized demographic methods with input and feedback from county, city, and other local stakeholders.

Coordinated Population Forecast For Tillamook County, Its Urban Growth Boundaries (Ugb), And Area Outside Ugbs 2024-2074, Neal Marquez, Ethan Sharygin, Huda Alkitkat, Suniva Thangaraj, Gilbert Montcho, David Swanson, Joshua Wilde

Oregon Population Forecast Program

This report for population forecasts for Tillamook County was made in compliance with Oregon House Bill 2253 relating to population forecasts for land use planning. Portland State University Population Research Center is tasked with creating population projections for all Oregon counties except Multnomah, Clackamas, and Washington as well as population forecasts for all Urban Growth Boundaries (UGBs), except for the Metro area UGB. These population forecasts are generated using standardized demographic methods with input and feedback from county, city, and other local stakeholders.

Coordinated Population Forecast For Yamhill County, Its Urban Growth Boundaries (Ugb), And Area Outside Ugbs 2024-2074, Neal Marquez, Ethan Sharygin, Huda Alkitkat, Suniva Thangaraj, Gilbert Montcho, David Swanson, Joshua Wilde

Oregon Population Forecast Program

This report for population forecasts for Yamhill County was made in compliance with Oregon House Bill 2253 relating to population forecasts for land use planning. Portland State University Population Research Center is tasked with creating population projections for all Oregon counties except Multnomah, Clackamas, and Washington as well as population forecasts for all Urban Growth Boundaries (UGBs), except for the Metro area UGB. These population forecasts are generated using standardized demographic methods with input and feedback from county, city, and other local stakeholders.

Individual Differences In The Cognitive-Behavioral Model Of Chronic Back Pain In Patients Receiving Spine Surgery: Towards Precision Phenotypes, Madelyn Frumkin

Arts & Sciences Graduate Student Theses and Dissertations

Chronic back pain impacts over 20 million adults in the United States and represents the costliest condition in our healthcare system. Treatments for chronic back pain range from cognitive-behavioral therapy to opioid pain medications and spine surgery. At present, it is extremely difficult to determine which treatments are likely to maximize benefit and minimize risk for a given patient. As such, the goal of this study was to examine whether individual differences in the cognitive-behavioral model of chronic back pain were associated with baseline characteristics or surgical outcomes. Patients (N = 95) with chronic back pain who were receiving spine …

Centennial Records Of Microplastics In Lake Cores In Huguangyan Maar Lake, China, Qingsong Ji, Yanxia Zhang, Yubao Xia, Xinkai Wang, Maoyong He, Yi Yang, Clive E. Sabel, Bin Huang, Fengxiao Zhu, Min Shao, Enze Xie, Guojing Yan, Guonai Li, Aoyu Zhou, Huan He, Limin Zhang, Zhangdong Jin

School of Geography, Earth and Environmental Sciences

Microplastic records from lake cores can reconstruct the plastic pollution history. However, the associations between anthropogenic activities and microplastic accumulation are not well understood. Huguangyan Maar Lake (HML) is a deep-enclosed lake without inlets and outlets, where the sedimentary environment is ideal for preserving a stable and historical microplastic record. Microplastic (size: 10-500 μm) characteristics in the HML core were identified using the Laser Direct Infrared Imaging system. The earliest detectable microplastics appeared unit in 1955 (1.1 items g^-1). The microplastic abundance ranged from n.d. to 615.2 items g^-1 in 1955-2019 with an average of 134.9 items …

Microencapsulation Of Cosmos Caudatus Kunth Extract Using Sodium Alginate And In Vitro Antioxidant Activity Test, Safina Samara Nur Fadlila, Oktavia Eka Puspita, Zubaidah Ningsih, Anna Safitri

Makara Journal of Science

This study aims to encapsulate Cosmos caudatus K. leaf extract in sodium alginate crosslinked with calcium chloride (CaCl₂) as coating materials through freeze-drying. Antioxidant assays were performed to evaluate the applicability of the microcapsules as antidiabetic medicines. Their characteristics, antioxidant activity, and encapsulation efficiency (EE) were also examined. Results indicated that the concentration of sodium alginate and pH influenced the manufacturing process of the microcapsules. The highest EE was obtained at pH 6 and alginate concentration of 2% (w/v). The IC₅₀ for the antioxidant activity of the microcapsules was 139.96 ± 1.094 μg/mL. Scanning electron microscopy confirmed …

Synthesis, Biological Activity, And Molecular Docking Study Of Xanthenol And Its Disproportionation Products As Anticancer And Antimalarial Agents, Ardhya Ayu Pratama, Jumina Jumina, Chairil Anwar

Makara Journal of Science

Xanthone and its derivatives are well known for their broad biological activities. This research aims to investigate the anticancer and antimalarial activities of synthesized xanthenol and xanthene compounds and to elucidate their mechanisms of action through molecular docking. The xanthenol compound was obtained through xanthone reduction with sodium triacetoxyborohydride, and xanthene synthesis was studied through three different reaction conditions: uncatalyzed and catalyzed by Lewis acid or Bronsted acid. The reduction reaction produced xanthenol in 30.50% yield, whereas the three reaction conditions produced xanthene and xanthone in 39.35–75.48% yield. An anticancer assay for Vero, WiDr, HeLa, and T47D cell lines was …

Benefits Of Plant Pigment, Quercetin, For Fish And Prawn, Yos Adi Prakoso, Jasir Hakim Hidayah, Michael Richard Sanjaya, Agga Dhigayuka Pratama, Annisha Permata Nurul Azhar, Arya Surya Kuswanto, Berlian Ronaldi April, Intan Karisma Utami, Mahera Sandi Sasmita Putra, Maria Paulina Wukak, Naufal Farros Satria

Makara Journal of Science

Quercetin is an important phytochemical that belongs to the flavonoid group of plant pigments. It has potential benefits as an antioxidant, antiviral, and anti-inflammatory agent. However, the utilization of quercetin in aquaculture is not optimal. Hence, this study conducted a literature review to analyze the potential benefits of quercetin in aquaculture, especially for fish and prawn. Results showed that quercetin can be isolated from herbs using several methods, including sonication, maceration, and fractionation. Its amount in plants can be potentially determined using high-performance liquid chromatography and thin-layer chromatography. Some of the plants containing high quercetin levels include shallot, garlic, apple …

Association Between Macrophage’S Cell Number And Maternal Factors In Human Milk, Ghaniyyatul Khudri, Dewi Sukmawati, Atikah Chalida Barasila, Dwi Anita Suryandari

Makara Journal of Science

Infant nutrition and immune protection require the consumption of human milk, with macrophages mainly contributing to immune defense and infant development. This study was performed to investigate the correlation between macrophage cell numbers in human milk and various maternal factors. Thirteen human milk samples were collected from lactating mothers and were evaluated for macrophage cell numbers using a hemacytometer. The recorded questionnaire containing several questions, including age, multivitamin consumption, coronavirus disease 2019 vaccination status, allergy history, and lactation duration, was used to determine the maternal factors. Pearson’s correlation and Mann-Whitney test was employed in statistical analysis, with p-values < 0.05 considered significant. The macrophage cell number reached 54.236 ± 7.456 cells per mL. Notably, a significant correlation was observed between maternal allergy history and the number of macrophage cells in human milk (p …