Digital Commons Network^™

Thermal Stability Of Amorphous Metal Oxides: The Interplay Of Secondary Cations, Degree Of Substitution, And Local Structure, Li Zeng, D. Bruce Buchholz, Denis T. Keane, Tobin J. Marks, Julia E. Medvedeva, Michael J. Bedzyk

Physics Faculty Research & Creative Works

Indium-based amorphous metal oxides (AMOs) are important materials that enable a wide range of electronic and optoelectronic applications. The metal cations that substitute for In are known to effectively tune the material properties as well as to retain the desirable amorphous state when subjected to high operating temperatures. While much attention focuses on property tuning, there is less focus on those fundamental factors that enhance thermal stability. Hence, in this paper, we employ in situ X-ray scattering and ab initio molecular dynamics (MD) to systematically study the effects of secondary cations on the crystallization process. A series of amorphous (In …

Salt Pollution Reduces Turbidity, Dissolved Organic Matter, And Cyanobacteria In Experimental Vernal Pool Communities, Jared P. Vigil, Matthew S. Schuler

Department of Biology Faculty Scholarship and Creative Works

Anthropogenic activities such as the over-application of road deicers are causing an increase in the concentration of salts in historically fresh waters. Experimental and field investigations demonstrate that freshwater salinization disrupts ecosystem functions and services, causing the death of freshwater organisms and changes to nutrient conditions. Wetland habitats are one system negatively affected by salt pollution, including ephemeral wetlands (vernal pools) that fill with salt-polluted water after snowmelt. In urbanized areas, the degradation of these ecosystems could result in irreversible ecological damage including reduced water quality and a reduction in biodiversity. To investigate the effects of freshwater salinization on vernal …

University Lands Prestigious T32 Award For Graduate Student Training, Natalie Ehrhardt

University of Mississippi News

OXFORD, Miss. – In a historic development for the University of Mississippi, the National Institutes of Health has awarded the university a prestigious grant to help support and train graduate students from groups underrepresented in STEM fields.

Optimized Cytogenetic Risk-Group Stratification Of Kmt2a-Rearranged Pediatric Acute Myeloid Leukemia., Romy E. Van Weelderen, Christine J. Harrison, Kim Klein, Yilin Jiang, Jonas Abrahamsson, Todd Alonzo, Richard Aplenc, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N. Dworzak, Sarah Elitzur, José M. Fernández Navarro, Alan S. Gamis, Robert B. Gerbing, Bianca F. Goemans, Hester A. De Groot-Kruseman, Erin M. Guest, Shau-Yin Ha, Henrik Hasle, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Ulrika Norén-Nyström, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, C Michel Zwaan, Gertjan J L Kaspers

Manuscripts, Articles, Book Chapters and Other Papers

A comprehensive international consensus on the cytogenetic risk-group stratification of KMT2A-rearranged (KMT2A-r) pediatric acute myeloid leukemia (AML) is lacking. This retrospective (2005-2016) International Berlin-Frankfurt-Münster Study Group study on 1256 children with KMT2A-r AML aims to validate the prognostic value of established recurring KMT2A fusions and additional cytogenetic aberrations (ACAs) and to define additional, recurring KMT2A fusions and ACAs, evaluating their prognostic relevance. Compared with our previous study, 3 additional, recurring KMT2A-r groups were defined: Xq24/KMT2A::SEPT6, 1p32/KMT2A::EPS15, and 17q12/t(11;17)(q23;q12). Across 13 KMT2A-r groups, 5-year event-free survival probabilities varied significantly (21.8%-76.2%; P < .01). ACAs occurred in 46.8% of 1200 patients with complete karyotypes, correlating with inferior overall survival (56.8% vs 67.9%; P < .01). Multivariable analyses confirmed independent associations of 4q21/KMT2A::AFF1, 6q27/KMT2A::AFDN, 10p12/KMT2A::MLLT10, 10p11.2/KMT2A::ABI1, and 19p13.3/KMT2A::MLLT1 with adverse outcomes, but not those of 1q21/KMT2A::MLLT11 and trisomy 19 with favorable and adverse outcomes, respectively. Newly identified ACAs with independent adverse prognoses were monosomy 10, trisomies 1, 6, 16, and X, add(12p), and del(9q). Among patients with 9p22/KMT2A::MLLT3, the independent association of French-American-British-type M5 with favorable outcomes was confirmed, and those of trisomy 6 and measurable residual disease at end of induction with adverse outcomes were identified. We provide evidence to incorporate 5 adverse-risk KMT2A fusions into the cytogenetic risk-group stratification of KMT2A-r pediatric AML, to revise the favorable-risk classification of 1q21/KMT2A::MLLT11 to intermediate risk, and to refine the risk-stratification of 9p22/KMT2A::MLLT3 AML. Future studies should validate the associations between the newly identified ACAs and outcomes and unravel the underlying biological pathogenesis of KMT2A fusions and ACAs.

Lifestyle Eco-Influencers Advertising: Is Engagement Driven By Content Or Fandom?, Bárbara Mercedes Castillo Abdul Hadi, Luis Miguel Romero Rodríguez, Carlos Fernández-Rodríguez

Artículos científicos

This research examines the main common characteristics among the contents of five eco- -influencer accounts from different Western countries. A quantitative content analysis was performed on 187 Instagram posts published by eco-influencers from the United Kingdom, United States, Belgium, Spain, and Peru. The topics that eco-influencers deal with the most are promoting veganism, spirituality, environmental and political claims, product advertising (their own and third-party), and personal life, generating the most interactions in the accounts. Carousels win on engagement for eco-influencers on Instagram despite videos being sponsors’ favorite format. Both sponsored content and sponsors themselves are well-received, with over half of …

Factors Associated With Functioning In Older Black Adults, Katrail D. Davis

LSU Master's Theses

Activities of daily living can be simple tasks such as bathing, showering, toileting or as complex as managing finances, driving, and preparing meals. Independence in everyday functioning has been associated with successful aging and declines in functioning may be indicative of pathological cognitive decline. Social determinants of health, like economic status and access to health care, also play a role in everyday functioning. Understanding these factors are of particular importance for older Black adults who have had long-standing disparate access to care, education, and treatments. The current study aimed to evaluate social determinants of health, more specifically social engagement, as …

Annual Comprehensive Financial Report, Shelby County, Tennessee For The Year Ended June 30, 2023, Shelby County (Tenn.). Department Of Finance.

Tennessee County Audit Reports

No abstract provided.

Quality Improvement: Naloxone Prescribing Practices For Paitent With An Opioid Patient Prescriber Agreement, Moniqueca Helms

Walden Dissertations and Doctoral Studies

The Substance Abuse Mental Health and Human Services Administration (SAMHSA) has set guidelines for opioid prescribing practices. The core principles of SAMHSA are to prevent overdose abuse and to provide appropriate treatment for those with an opioid abuse disorder. The concern addressed by the Doctor of Nursing Practice project was the gap in physician education regarding a Best Practice Alert (BPA) in the Electronic Medical Record that appears when prescribing an opioid to a patient without cancer. The alert indicates best practice is to prescribe naloxone with the opioid prescription. The naloxone BPA education project was implemented using the exploration, …

Design, Fabrication, And Characterization Of Multifunctional Cellular Structures For Enhanced Impact Energy Mitigation Performance, Kazi Zahir Uddin

Theses and Dissertations

This dissertation investigates the relationship between the structural design of cellular solids and their macroscopic behavior and focuses on the customization of properties through advanced fabrication techniques. The concepts of density gradation and their integration in both non-ordered and ordered cellular structures have been proposed. The investigation focuses on the development of functionally graded foam materials (FGFMs) and mechanical metamaterials to obtain tunable mechanical performance. One significant focus is the fabrication of density-graded foam stacks with various interface adhesives. From the insights gained from the study of interfaces in density-graded foams, certain design and fabrication principles are applied to enhance …

Maximizing The Impact: The Vital Role Of Medical Surplus Recovery Organizations, Sarah Meffert, Chanelle Pearson, Sharrissa Beckford, Chioma Ezeji, Amy Simons

Global Advocacy

Medical Surplus Recovery Organizations (MSROs) play a vital role in closing the gap in global healthcare disparities. These organizations collect unused medical supplies, devices, and medicines, turning potential waste into hope for those in need. In this presentation we advocate for the use of MSROs, identify stakeholders, and provide a plan to determine effectiveness of the awareness campaign.

Cross-Sectional Analysis Of The Association Between Household Food Insecurity And Mental Health Conditions In Children Aged 5–11 Years In Canada, Justin Thielman, Sarah Orr, Saranya Naraentheraraja, Daniel Harrington, Sarah Carsley

Faculty, Staff and Student Publications

BACKGROUND: Children living in food insecure households have poorer mental health outcomes compared with their food-secure peers; however, the relationship between the severity of food insecurity and diagnosed mental health conditions in young children remains unknown. This study examined the association between household food insecurity and reported diagnosed mental health conditions among children aged 5-11 years in Canada.

METHODS: This study included 16 216 children aged 5-11 years living in Canada, from the 2019 Canadian Health Survey on Children and Youth. We measured household food insecurity using the Household Food Security Survey Module. We measured diagnosed mental health conditions by …

Make It Funny! Developing A Novel Humor-Based Digital Positive Psychology Intervention To Investigate The Influence Of Duchenne Laughter And Mirth On Psychological Distress In Daily Life, Joshua Semko

Electronic Theses and Dissertations

The aim of the present research was to develop a novel digital humor-based PPI (Make it Funny!) to investigate the influence of Duchenne laughter and mirth on psychological distress in daily life. Participants (N = 159; Age_­median­ = 39 years; 47.77% biologically female; 68.15% White) were tasked with completing Make it Funny! or a placebo activity every day for 7 days. Duchenne laughter frequency had a small negative cross-sectional moderation effect on the relationship between the occurrence of stressful events psychological distress (t(79.71) = -2.33, b = -10.89, p = .022). Within participants, Duchenne laughter …

Impact Of Rural Location On Receipt Of Standard Of Care Treatment And Survival For Locally Advanced Bladder Cancer In Louisiana, Megan Escott, Yong Yi, Ashley Foret, Ting Ting Li, Mei Chin Hsieh, Scott E. Delacroix, Xiao Cheng Wu, Mary E. Westerman

School of Public Health Faculty Publications

Objective: We aim to determine the effect of region of residence (urban vs. rural) on the odds of receiving standard of care treatment for locally advanced BCa in Louisiana and its impact on survival outcomes. Methods: Using the Louisiana Tumor Registry, we identified American Joint Committee on Cancer (AJCC) stage II or III, BCa diagnoses in Louisiana residents between 2010 and 2020. Treatment received was classified as standard or non-standard of care according to American Urological Association (AUA) guidelines and location of residence was determined using Rural Urban Commuting Area-Tract-level 2010 (RUCA). Multivariable logistic regression analyses and multivariate cox proportional …

A Harmonized Public Resource Of Deeply Sequenced Diverse Human Genomes, Zan Koenig, Mary T Yohannes, Lethukuthula L Nkambule, Xuefang Zhao, Julia K Goodrich, Heesu Ally Kim, Michael W Wilson, Grace Tiao, Stephanie P Hao, Nareh Sahakian, Katherine R Chao, Mark A Walker, Yunfei Lyu, Heidi L Rehm, Benjamin M Neale, Michael E Talkowski, Mark J Daly, Harrison Brand, Konrad J Karczewski, Elizabeth G Atkinson, Alicia R Martin

Faculty, Staff and Students Publications

Underrepresented populations are often excluded from genomic studies owing in part to a lack of resources supporting their analyses. The 1000 Genomes Project (1kGP) and Human Genome Diversity Project (HGDP), which have recently been sequenced to high coverage, are valuable genomic resources because of the global diversity they capture and their open data sharing policies. Here, we harmonized a high-quality set of 4094 whole genomes from 80 populations in the HGDP and 1kGP with data from the Genome Aggregation Database (gnomAD) and identified over 153 million high-quality SNVs, indels, and SVs. We performed a detailed ancestry analysis of this cohort, …

June 25, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Innate And Adaptive Immune Responses That Control Lymph-Borne Viruses In The Draining Lymph Node, Carolina R. Melo-Silva, Luis J. Sigal

Department of Microbiology and Immunology Faculty Papers

The interstitial fluids in tissues are constantly drained into the lymph nodes (LNs) as lymph through afferent lymphatic vessels and from LNs into the blood through efferent lymphatics. LNs are strategically positioned and have the appropriate cellular composition to serve as sites of adaptive immune initiation against invading pathogens. However, for lymph-borne viruses, which disseminate from the entry site to other tissues through the lymphatic system, immune cells in the draining LN (dLN) also play critical roles in curbing systemic viral dissemination during primary and secondary infections. Lymph-borne viruses in tissues can be transported to dLNs as free virions in …

Long-Term Outcomes In Patients Using Protocol-Directed Active Surveillance For Prostate Cancer, Lisa F. Newcomb, Jeannette M. Schenk, Yingye Zheng, Menghan Liu, Kehao Zhu, James D. Brooks, Peter R. Carroll, Atreya Dash, Claire M. De La Calle, William J. Ellis, Christopher P. Filson, Martin E. Gleave, Michael A. Liss, Frances Martin, Jesse K. Mckenney, Todd M. Morgan, Maria S. Tretiakova, Andrew A. Wagner, Peter S. Nelson, Daniel W. Lin

Markey Cancer Center Faculty Publications

IMPORTANCE: Outcomes from protocol-directed active surveillance for favorable-risk prostate cancers are needed to support decision-making.

OBJECTIVE: To characterize the long-term oncological outcomes of patients receiving active surveillance in a multicenter, protocol-directed cohort.

DESIGN, SETTING, AND PARTICIPANTS: The Canary Prostate Active Surveillance Study (PASS) is a prospective cohort study initiated in 2008. A cohort of 2155 men with favorable-risk prostate cancer and no prior treatment were enrolled at 10 North American centers through August 2022.

EXPOSURE: Active surveillance for prostate cancer.

MAIN OUTCOMES AND MEASURES: Cumulative incidence of biopsy grade reclassification, treatment, metastasis, prostate cancer mortality, overall mortality, and recurrence after …

Intrahousehold Welfare: Theory And Application To Japanese Data, Pierre-André Chiappori, Costas Meghir, Yoko Okuyama

Cowles Foundation Discussion Papers

In this paper we develop a novel approach to measuring individual welfare within house-holds, recognizing that individuals may have both different preferences (particularly regarding public consumption) and differential access to resources. We construct a money metric mea-sure of welfare that accounts for public goods (by using personalized prices) and the allocation of time. We then use our conceptual framework to analyse intrahousehold inequality in Japan, allowing for the presence of two public goods: expenditures on children and other public goods including housing. We show empirically that women have much stronger preferences for both public goods and this has critical implications …

"It Feels Like I'M A Step Closer To My Ultimate Goal Of Stable Housing:" A Qualitative Study Of Unhoused People's Experiences In Alternative Shelters In Portland, Emily Leickly, Jacen Greene, Todd Ferry

Psychology Faculty Publications and Presentations

In recent years, alternatives to congregate shelters have emerged, including tiny home villages and motel conversions. Existing research indicates that these alternative shelter modalities are associated with positive outcomes for shelter guests. This qualitative study was conducted with 11 participants staying in three alternative shelters tailored to support specific groups: lesbian, bisexual, gay, transgender, queer, intersex, and asexual (LGBTQIA+) people, women, and medically vulnerable people. Participants reported a number of facilitators and barriers to meeting their personal goals (e.g., permanent housing, medical care). Key facilitators included the relative privacy, autonomy, and safety of alternative shelters, and support for guests with …

Tn Rehabilitative Initiative In Correction For The Year Ended June 30, 2023, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

Increasing Access To Non-Dairy Beverages And Commercial Thickeners, Kathleen Carr

General Submissions: Presentations (Oral and Poster)

The primary aim of the project was to identify whether financial assistance in the form of product vouchers for non-dairy (later expanded to include dairy) or commercially available thickeners impacts the time from initial recommendation to identification of a tolerated product. A secondary aim included identifying whether financial assistance in the form of product vouchers for non-dairy (later expanded to include dairy) beverages or commercially available thickeners impacts insurance coverage.

Sunlight Solutions: Optimizing 25(Oh)D Concentrations In Global Maternal Health Strategies To Improve Maternal Outcomes And Preserve Healthcare Resources, Beth Sanford

Global Advocacy

In 2020, the World Health Organization identified the Global maternal mortality rate was a staggering 223 per 100,000. As a result, the United Nations created Sustainable Development Goal 3.1, with the hope of "reducing the global MMR to less than 70 per 100 000 births, with no country having a maternal mortality rate of more than twice the global average" by 2030.

Optimizing 25(OH)D serum concentrations to a minimum of 40 ng/mL (100 nmol/L) has been proven to be a safe, affordable, and effective way to improve perinatal outcomes such as decreasing maternal mortality as well as morbidities such as …

Climate Challenge For Sigma Chapters, Kathy Burlingame, Michelle Dephillips, Michelle Gilbert, Kelly Kuhns, Daria Waszak

Global Advocacy

There are a plethora of health effects connected to climate change's impacts on weather, food, water, air, heat, vectors, allergens, and more. As a trusted voice, nurses are in an opportune position to advocate for climate action and its related impacts on health. Whilst, the topic of climate change should be integrated more consistently through curricula for nurses. With that in mind, The Nurses Climate Challenge, a campaign of the ANHE and Healthcare Without Harm, was launched in 2018. Its initial aim of engaging 50,000 nurses was met, and the initiative is being transferred to ANHE this month.

Foster Parents Assisting Transitioning Foster Care Youth In Maintaining Stable Housing, Cecilann Morrison

Walden Dissertations and Doctoral Studies

Foster Parents Assisting Transitioning Foster Care Youth in Maintaining Stable Housing by Cecilann Morrison MA, National University, 2013 BS, Fresno Pacific University, 2011 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Human and Social Service Walden University June 2024

Strategies For Evaluating Training For Field Engineers In The Aerospace And Defense Industry, Nathan D. Johnson

Walden Dissertations and Doctoral Studies

Inefficient training strategies are just one of the many challenges field engineer managers face in the aerospace and defense industry. Aerospace and defense managers and customers are concerned because inefficient training strategies for field engineers impact how well they can effectively contribute to organizational and customer mission success in operations around the globe. Grounded in the Kirkpatrick model, the purpose of this qualitative pragmatic inquiry was to explore strategies aerospace and defense managers use to evaluate field engineer training programs. The participants were five aerospace and defense managers who successfully implemented training evaluation strategies. Data were collected from semistructured interviews …

Porphyrin Overdrive In Cancer: Unraveling The Mechanisms And Therapeutic Potential, Pravin D. Meshram

USF Tampa Graduate Theses and Dissertations

The increased understanding of cancer cell metabolism has shown options for novel treatment strategies. This thesis looks at the role of heme metabolism, specifically "porphyrin overdrive," in cancer progression and treatment. Cancer cells are hypermetabolic and rely on heme synthesis. When treated with δ-aminolevulinic acid (ALA), they abnormally accumulate heme intermediates. This metabolic weakness presents an opportunity to exploit heme synthesis in targeted cancer therapy. In this study, we suggest a "Bait and Kill" technique that uses exogenous ALA to induce protoporphyrin IX (PpIX) buildup in cancer cells, making them more susceptible to oxidative stress. We investigate the possibility of …

Car T-Cell Expansion: Harmful Or Helpful?, Anath C Lionel, Sattva S Neelapu

Faculty, Staff and Student Publications

No abstract provided.

Hypoxia Inducible Factor 2Α Promotes Tolerogenic Macrophage Development During Cardiac Transplantation Through Transcriptional Regulation Of Colony Stimulating Factor 1 Receptor, Matthew Deberge, Samantha Schroth, Fanfan Du, Xin Yi Yeap, Jiao-Jing Wang, Zheng Jenny Zhang, Mohammed Javeed Ansari, Evan A Scott, Edward B Thorp

Faculty, Staff and Student Publications

Solid organ transplantation mobilizes myeloid cells, including monocytes and macrophages, which are central protagonists of allograft rejection. However, myeloid cells can also be functionally reprogrammed by perioperative costimulatory blockade to promote a state of transplantation tolerance. Transplantation tolerance holds promise to reduce complications from chronic immunosuppression and promote long-term survival in transplant recipients. We sought to identify different mediators of transplantation tolerance by performing single-cell RNA sequencing of acute rejecting or tolerized cardiac allografts. This led to the unbiased identification of the transcription factor, hypoxia inducible factor (HIF)-2α, in a subset of tolerogenic monocytes. Using flow cytometric analyses and mice …

Cracd Loss Induces Neuroendocrine Cell Plasticity Of Lung Adenocarcinoma, Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park

Faculty, Staff and Student Publications

Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, some lung adenocarcinoma (LUAD) cells transform into neuroendocrine (NE) tumor cells. However, the mechanisms of NE cell plasticity remain unclear. CRACD (capping protein inhibiting regulator of actin dynamics), a capping protein inhibitor, is frequently inactivated in cancers. CRACD knockout (KO) is sufficient to de-repress NE-related gene expression in the pulmonary epithelium and LUAD cells. In LUAD mouse models, Cracd KO increases intratumoral heterogeneity with NE gene expression. Single-cell transcriptomic analysis showed that Cracd KO-induced NE cell plasticity is associated with cell de-differentiation and stemness-related pathway activation. The …

A Spatiotemporal Map Of Co-Receptor Signaling Networks Underlying B Cell Activation, Katherine J Susa, Gary A Bradshaw, Robyn J Eisert, Charlotte M Schilling, Marian Kalocsay, Stephen C Blacklow, Andrew C Kruse

Faculty, Staff and Student Publications

The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. Here, we take advantage of peroxidase-catalyzed proximity labeling combined with quantitative mass spectrometry to track co-receptor signaling dynamics in Raji cells from 10 s to 2 h after BCR stimulation. This approach enables tracking of 2,814 proximity-labeled proteins and 1,394 phosphosites and provides an unbiased and quantitative molecular map of proteins recruited to the vicinity of CD19, the signaling subunit of the co-receptor complex. We detail the recruitment kinetics of signaling effectors to CD19 and identify previously uncharacterized …