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Real-Life Experience On The Effect Of Sglt2 Inhibitors Vs. Finerenone Vs. Combination On Albuminuria In Chronic Kidney Disease, Mohamad Hanouneh, Dustin Le, Bernard G. Jaar, Christina Tamargo, C. Elena Cervantes

Division of Nephrology Faculty Papers

BACKGROUND: There have been several recent advances in the care of patients with chronic kidney disease (CKD), including the use of sodium glucose cotransporter 2 (SGLT2) inhibitors and selective mineralocorticoid receptor antagonists (MRAs). There are very few data reporting the outcomes of these treatments in real-world experience. The aim of this retrospective study is to report the effects of SGLT2 inhibitors, finerenone, and their combination in CKD patients in our community-based setting.

METHODS: Ninety-eight patients with CKD with an estimated glomerular filtration rate (eGFR) between 25 and 90 mL/min per 1.73 m² and a urine albumin-to-creatinine ratio (UACR) ≥ …

How Water-Soluble Lubricants Effects Perineal Tears, Jordan Crospeno Bsn, Rn, Daria Maggio Rn, Madison Muller Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Provider In Triage, Emma Blades Bsn, Rn, Grace Gilmore Bsn, Rn, Katelyn Mcmurtrie Rn, Skylar Treat Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Educating Rn's On Proper Use Of Pulse Oximetry To Improve Patient Safety, Juleeanna Held Bsn, Rn, Briana Kenton Bsn, Rn, Genevieve Ashley Bsn, Rn, Alex Colon Bsn, Rn, Faith Steffanic Rn, Sebasthian Malave Santos Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Emotional Reactivity And Recognition Deficits In Individuals With Callous-Unemotional (Cu) Traits: A Multilevel Meta-Analysis, Emily C. Kemp

LSU Doctoral Dissertations

Youth and adults with antisocial behavior present a significant mental health concern. Elevated callous-unemotional (CU) traits, characterized by deficient empathy and remorse, distinguish clinically important subgroups of antisocial individuals who present with more severe behavior and distinct cognitive-affective characteristics that may help to explain the underlying causes of their antisocial behavior and inform more effective treatments. Specifically, two mechanisms theorized to underlie the development of elevated CU traits by way of atypical empathy development are deficient reactivity to and recognition of others’ emotions. Though a substantive literature base reports associations between CU traits and emotional processing deficits, significant inconsistencies remain. …

The Collaborative Assessment And Management Of Suicdality As A Single Session Intervention For Patients Admitted To Inpatient Psychiatric Care For Suicidal Thoughts And Behaviors, D Nicolas Oakey-Frost

LSU Doctoral Dissertations

Inpatient psychiatric care is a critical contact point for individuals experiencing suicidal thoughts and behaviors (STB). The Zero-Suicide framework provides useful scaffolding for improving suicide prevention within inpatient psychiatry (i.e., Assess, Intervene, and Monitor [AIM-SP]). Available evidence suggests instruments are available for evidence informed risk assessment but are hindered by low construct validity and a limited collaborative approach. Additionally, extant interventions do not typically target STB and are not optimized for inpatient psychiatric care. The Collaborative Assessment and Management of Suicidality (CAMS) meets the criteria of the Zero-Suicide Framework and is often leveraged as a single session intervention (SSI) but …

The Potential For Conflicts Between Ccs Projects And Mineral Extraction, Joseph A. Schremmer

LSU Journal of Energy Law and Resources

No abstract provided.

Do We Have To Litigate Title? An Analysis Of The State Of Louisiana’S Legal Authority To Resolve Title Disputes Arising From Conflicting Mineral Claims Short Of Title Trials That Risk The Loss Of Public Trust Resources, James Anderson, Ryan M. Seidemann, Warren B. Bates, Jr.

LSU Journal of Energy Law and Resources

No abstract provided.

Do Not Pass Go, Do Not Collect $200: Ending Louisiana’S Monopoly Energy System Through Implementation Of An Industrial Customer Market Option And A Renewable Generation Option, Miranda Scotten

LSU Journal of Energy Law and Resources

No abstract provided.

The Wild West Of The Coast: The Need To Regulate Louisiana’S Gulf Menhaden Fishery, Camille Webre

LSU Journal of Energy Law and Resources

No abstract provided.

Flushing Away Ambiguity: Establishing A Standard For The Flushability Of Pre-Moistened Nonwoven Wipes, Patrick Van Burkleo

LSU Journal of Energy Law and Resources

No abstract provided.

It’S Going To Be A Bumpy Ride, Especially In Louisiana: Why Louisiana Needs To Rethink Its Funding For Road Maintenance And Development, Nathan Bromley

LSU Journal of Energy Law and Resources

No abstract provided.

Functional Studies Of Dcaf14 In Replication Fork Stability And Genome Integrity, Neysha Tirado-Class

USF Tampa Graduate Theses and Dissertations

The response to replication stress is critical for ensuring the stability of replication forks and preserving genome integrity. To aid this response, several factors are recruited to stalled replication forks to prevent irreversible collapse of the replication machinery. Replication fork proteomic analyses of stalled forks reveal enrichment of DCAF14, a component of the Cullin4-RING (CRL4) E3 ubiquitin ligase complex, that mediates replication fork protection by blocking nuclease-mediated digestion of nascent DNA. However, little is known about the molecular mechanism by which DCAF14 functions in the context of replication stress. Notably, loss of function mutations in DCAF14 are associated with a …

Rural Black Women’S Self-Help Activism In The Arkansas Delta, Local Heritage, And Global Resonance: Mrs. Gertha Bailey Trice And The Lee County Self-Help Project, Swity Sultana Monni

Student Theses and Dissertations

In the mid-to-late twentieth century, through outstanding and transformative leadership, rural Black women activists in the Arkansas Delta worked to confront significant problems facing their communities, in the contexts of health, education, and social justice; their efforts were often apolitical in nature, at least overtly. These women went beyond the demands of many mid-twentieth-century civil rights activists to create spaces to articulate and demand human rights, broadly conceived. This in-depth study explores the community activism of Gertha Bailey Trice of Lee County, Arkansas, who engaged in broadly defined African American self-help traditions through her work with the Lee County Self …

Correlation Between Pass Speed, Leg Strength And Explosive Leg Performance In Male Soccer Players, Keigo Kobayashi

Student Theses and Dissertations

This study examined correlation between inside pass speed and performance and descriptive variables among male soccer players. Eighteen players from a University men’s soccer club team completed performance tasks and a lower body muscular strength task. Descriptive data (age, weight, height, body mass index, body fat percentage and years of experience) were also collected. Pearson correlation examined relationships between pass speed and each performance and descriptive variable. Average pass speed was 81.24 ± 12.71 km/h. Only the 4-counter movement jump height and sprint were significantly correlated to pass speed. No relationship was found between the other performance tasks and any …

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Turkish Journal of Biology

No abstract provided.

O-Demethyl Galantamine Alters Protein Expression In Cerebellum Of 5xfad Mice, İrem Kiriş, Merve Karayel Başar, Büşra Gurel, Tomasz Mroczek, Ahmet Tarik Baykal

Turkish Journal of Biology

Background/aim: Alzheimer’s disease (AD), one of the most common health issues, is characterized by memory loss, severe behavioral disorders, and eventually death. Despite many studies, there are still no drugs that can treat AD or stop it from progressing. Previous in vitro tests showed that O-demethyl galantamine (ODG) might have a therapeutic potential owing to its 10 times higher acetylcholinesterase inhibitory activity than galantamine (GAL). Materials and methods: We aimed to assess effect of ODG on a molecular level 12-month-old 5xFAD Alzheimer’s mouse model. To this end, following the administrations of ODG and GAL, used as a positive control, protein …

Petox-Dope Nanoliposomes Functionalized With Peptide 563 In Targeted Bikdda Delivery To Prostate Cancer, Ayca Ece Nezi̇r, Zeynep Büşra Bolat, Ongun Mehmet Saka, Itir Ebru Zemheri̇, Sevgi̇ Gülyüz, Umut Uğur Özköse, Özgür Yilmaz, Asuman Bozkir, Fi̇kretti̇n Şahi̇n, Di̇lek Telci̇

Turkish Journal of Biology

BackgroundNanocarrier-based systems have cultivated significant improvements in prostate cancer therapy. However, the efforts are still limited in clinical applicability, and more research is required for the development of effective strategies. Here, we describe a novel nanoliposomal system for targeted apoptotic gene delivery to prostate cancer.MethodsPoly (2-ethyl-2-oxazoline) (PEtOx) dioleoyl phosphatidylethanolamine (DOPE) nanoliposomes were conjugated with the prostate-specific membrane antigen (PSMA)-targeting peptide GRFLTGGTGRLLRIS (P563) and loaded with BikDDA, a mutant form of the proapoptotik Bik. We selected 22Rv1 cells with moderate upregulation of PSMA to test the in vitro uptake, cell death, and in vivo anti-cancer activity of our formulation, P563-PEtOx-DOPE-BikDDA.ResultsBikDDA was …

The Apoptotic Effect Of Garlic (Allium Sativum) Derived Sevs On Different Types Of Cancer Cell Lines In Vitro, Naz Ünsal, Polen Koçak Deni̇zci̇, Hazal Yilmaz, Fi̇kretti̇n Şahi̇n, Merve Yildirim Canpolat

Turkish Journal of Biology

Small extracellular vesicles (SEVs) are known to have an impact on the physiological circumstances of the target cells, are a critical component of cell-to-cell communication and have been implicated in a variety of diseases. Although it has been proposed that edible plant-derived nanoparticles have effect on communication with mammalian cells, the influence of these nanoparticles on cancer cell development has yet to be explored. In order to characterize small extracellular vesicles obtained from garlic, specific SEV surface markers and antibodies and size detections were performed by using scanning electron microscopy and nanoparticle tracking analysis. Human hepatoma, Hep3B, human neuroblastoma SH-SY5Y, …

Proteomic Investigation Of Acute And Chronic Hypoxia /Reoxygenation Responsive Proteins And Pathways In H9c2 Cardiomyoblasts, Merve Öztuğ, Evren Kilinç, Zeynep A. Öztuğ Durer, Emel Baloğlu

Turkish Journal of Biology

Background/Aim: Ischemic heart diseases continue to be a significant global cardiovascular problem in today's world. Myocardial reperfusion (R) is provided with an effective and rapid treatment; however, it can lead to fatal results as well as ischemia (I). This study aims to use proteomic analysis to assess proteins and pathways in H9C2 cardiomyoblast cells exposed to hypoxic conditions, followed by reoxygenation, representing I /R injury for both short and long terms, reflecting acute and chronic hypoxia, respectively. Utilizing advanced techniques, our goal is to identify and characterize key proteins undergoing alterations during these critical phases.Materials and methods: H9C2 cardiomyoblasts, commonly …

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Self And Tell: Exploring Identity Through Music, Logen Crandall

Honors Theses

My honors thesis is a five-song EP titled ‘self and tell’. It is considered an EP (Extended Play) because it is longer than one song but shorter than an album. As an English: Creative Writing major, I wanted to write something for my thesis that truly excited me. However, I was ignited by the thought of writing an essay, play, collection of poems, or work of fiction. As someone who has always had a passion for music and singing, I instead chose to use my knowledge of poetry and storytelling to write lyrics that followed a central theme from one …

Unh Receives Usda Grant To Boost Climate-Resilient Farming Practices, Nicholas Gosling

UNH Today Archive

No abstract provided.

Neuroendocrine Gene Subsets Are Uniquely Dysregulated In Prostate Adenocarcinoma, Nicole M. Naranjo, Anne Kennedy, Anna Testa, Cecilia E. Verrillo, Adrian D. Altieri, Rhonda Kean, D. Craig Hooper, Jindan Yu, Jonathan Zhao, Oliver Abinader, Maxwell W. Pickles, Adam Hawkins, William Kevin Kelly, Ramkrishna Mitra, Lucia R. Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Prostate cancer has heterogeneous growth patterns, and its prognosis is the poorest when it progresses to a neuroendocrine phenotype. Using bioinformatic analysis, we evaluated RNA expression of neuroendocrine genes in a panel of five different cancer types: prostate adenocarcinoma, breast cancer, kidney chromophobe, kidney renal clear cell carcinoma and kidney renal papillary cell carcinoma. Our results show that specific neuroendocrine genes are significantly dysregulated in these tumors, suggesting that they play an active role in cancer progression. Among others, synaptophysin (SYP), a conventional neuroendocrine marker, is upregulated in prostate adenocarcinoma (PRAD) and breast cancer (BRCA). Our analysis shows that SYP …

Predictors Of Hiv Knowledge, Perceived Stigma And Risk Among Transport Workers In Mbarara City, Southwestern Uganda, Benjamin Betunga, Lilian Nuwabaine, Eve Katushabe, Grace Among, Grace Nakate, Ahmed Sarki, Diana Mbattude, Mary Namuguzi, John Baptist Asiimwe

School of Nursing & Midwifery, East Africa

Background: The human immunodeficiency virus (HIV) prevalence among transport workers in sub-Saharan Africa remains high, estimated at as high as 9.9% in western Uganda compared with the national prevalence of 5.4%. The prevalence of HIV among transport workers has been partly attributed to the level of knowledge regarding HIV prevention, perceived HIV risk, and stigma. Accordingly, these have been linked to high-risk HIV transmission behaviours that increase the chances of acquiring HIV among adults. Therefore, this study investigated the predictors of HIV knowledge, perceived HIV risk, and stigma among transport workers in Mbarara city in southwestern Uganda.

Methods: The …

Nursing Student Perceptions Of Presence In A Virtual Learning Environment: A Qualitative Description Study, Jason R. Thrift

Dissertations

Multifaceted approaches to learning are used for educating student nurses. One common teaching modality in nursing education, simulation, provides hands-on experiences in a safe environment to prepare student nurses for professional roles. High quality simulation standards recommend an engaging immersive experience, with physical, emotional, and conceptual fidelity to clinical practice. Presence is the perception of being there in a simulation as if it were real. Studies have reported improved learning outcomes with increased sense of presence. A simulation modality seldom used in nursing education is virtual reality simulation (VRSim) a three dimensional, immersive experience. VR-Sim with head mounted visual and …

Psychometric Properties Of The Modified Parenting Attitudes Measure Among African American Adolescents In Public Housing, Melissa L. Villodas, Andrew Foell, Lisa C. Smith, Mansoo Yu, Henrika Mccoy, Yibin Yang, Ngozi V. Enelamah, Margaret Lombe, Von Nebbitt

Faculty Publications

Valid and reliable measurements reflecting how perceived maternal and paternal parenting practices are similar, different, complementary, or additive in studying youth outcomes are critical for building knowledge on supportive parenting practices for African American youth living in public housing. We examined the psychometric properties of the Parental Attitudes Measure (PAM) which focuses on youths’ attitudes on parenting practices. Data was collected from the perspective of 660 African American youth living in urban public housing across three cities in the northeast and mid-Atlantic region in the United States. Youth reported on their attitudes about maternal and paternal caregivers. Reliability was determined …

Research Summaries: Artificial Intelligence And Data For Nonprofits, Erica Jensen

Journal of Nonprofit Innovation

No abstract provided.

Veterans Justice Outreach Program, Risk Of Recidivism, And Justice-Involved Veterans, Melody C. Weathers

Walden Dissertations and Doctoral Studies

To date, no study has examined whether the Veterans Justice Outreach (VJO) program influences recidivism once a justice-involved veteran (JIV) completes the program. Nor has a study examined the diagnoses and comorbidities between a JIV’s propensity for recidivism following separation from the VJO. One of the VJO program’s goals has been to end JIVs' contact with the criminal justice system. This study utilized a generic qualitative design that aimed to explore JIVs who received treatment from the VJO and whether there was an effect on their risk of recidivism. Additional elements for exploration included posttraumatic stress disorder, traumatic brain disorder, …

Natural Hazards Triggering Technological Disasters: Source Identification, Vulnerability, And Evaluation Of Emergency Preparedness In A Southern California City, Lisa Peumsang

Walden Dissertations and Doctoral Studies

Natural hazards triggering technological disasters (natech) events exist around the world and affect people, infrastructure, the economy, and environment but are not often considered for local hazard mitigation and emergency preparedness plans. The purpose of this qualitative case study was to identify (a) the natech event vulnerability of the target city, which is in the western United States, and potential sources for these events and (b) the extent to which the city’s hazard mitigation and emergency operations plans addressed natech events. The vulnerability assessment was performed through the lens of network risk theory and involved secondary data analysis of publicly …