Digital Commons Network^™

Distinct Genetic Liability Profiles Define Clinically Relevant Patient Strata Across Common Diseases, Lucia Trastulla, Georgii Dolgalev, Sylvain Moser, Laura T. Jiménez-Barrón, Till F. M. Andlauer, Moritz Von Scheidt, Schizophrenia Working Group Of The Psychiatric Genomics Consortium:, Douglas M. Ruderfer, Stephan Ripke, Andrew Mcquillin, Eli A. Stahl, Enrico Domenici, Rolf Adolfsson, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Martin Begemann, Richard A. Belliveau Jr., Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Douglas H. R. Blackwood, Anders D. Borglum, Nancy G. Buccola, Et Al

School of Nursing Faculty Publications

Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor profiles to deconstruct clinical heterogeneity. Contemporary approaches to this problem rely on polygenic risk scores (PRS), which provide only limited clinical utility and lack a clear biological foundation. To overcome these limitations, we develop the CASTom-iGEx approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue specific gene expression levels. The paradigmatic application of this approach to coronary artery …

The Overall Response Rate And Disease Free Survival In Patients With Diffuse Large B-Cell Lymphoma Treated With Standard Therapy, Azzam Ahmed, Alaadin Naji

Iraqi Postgraduate Medical Journal

ABSTRACTIntroduction: Diffuse large B-cell lymphoma (DLBCL) constitutes 30%–58% of non-Hodgkin’s lymphomas. Treatment strategies should be stratified according to age, IPI and feasibility of dose-intensified approaches. Six cycles of combination chemotherapy (R-CHOP) is the current standard. Aim of the study: To assess the response rate and disease free survival in patients with Diffuse Large B- cell Lymphoma treated with standard therapy (R-CHOP).Patients and methods: An ambidirectional cross-sectional study with data obtained from November 2020 till December 2021 from Baghdad Teaching hospital / Department of Hematology. A total 100 adult patients who were diagnosed with diffuse large B cell lymphoma (DLBCL) and …

Outcome Of Retrograde Intrarenal Surgery In Mangment Of Renal Stone Below 15 Mm, Muhamed Al_Habib, Yousuf Al Hallaq

Iraqi Postgraduate Medical Journal

Background: To investigate the Outcome and complication of retrograde intrarenal surgery for renal stone below 15mm, and evaluate our experience with this type of surgeries.Aim of the study : To evaluate our experience with flexible ureteroscope in treatment of renal stone below 15 mm and focusing on the operative time, stone free rate and possible complication .Patient and methods : From August 2019 to December 2020 a 44 patient were selected to perform retrograde intrarenal surgery for renal stone below 15mm, using flexible ureteroscope with holmium laser.Results : This cross sectional study show mean stone diameter 11.75±1.658 mm. mean operative …

The Correlation Of Human Leukocyte Antigen (Hla) Haplotypes With Clinical And Laboratory Profiles Of Celiac Disease In Children, Raghad Dawood, Raghad Najem, Arabiya Ali, Rabab Farhan

Iraqi Postgraduate Medical Journal

Background:Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is the major protein component of wheat, rye, and barley, the major predisposing genes are the HLA-DQ2 and DQ8 genotypes found in at least 95% of patients. Achieving early diagnosis of coeliac disease is critical to ensuring good lifelong health and providing children with the ability to thrive .Objective:To demonstrate the profiles of coeliac disease (the way in which coeliac disease present , to find out age and sex distribution , endoscopical and histopathological finding) and to analyze the correlation of HLA haplotypes …

Autism Spectrum Disorder In Baghdad: Preliminary Study, Zainab Saleem, Ali Ali, Hussein Meften, Ziad Abd Ali

Iraqi Postgraduate Medical Journal

Background. Mental health special services for children and adolescents are inadequate in Iraq. Autism spectrum disorder (ASD) is increasing in prevalence worldwide with no study illustrating the incidence and prevalence of ASD in Iraq. More information is needed regarding autism in Iraq, the most presenting symptoms which cause the referral and the way of referral to the child and adolescent mental health services to improve these services and for a better outcome. Method by taking all the children with a diagnosis of ASD who visited the child and adolescent outpatient mental health center at the children welfare hospital coming from …

Evaluation Of Haematological Parameters In Patients With Covid 19 Infection In Nineveh Province, Saba Soltan, Muna Kashmoola, Marwa Alsaraj

Iraqi Postgraduate Medical Journal

Background: In December 2019, a novel virus later named severe acute respiratory syndrome coronavirus-2 was isolated from the broncho-alveolar fluid of a patient in Wuhan, suffering from what became known as coronavirus disease 2019 (COVID-19). The first case was registered in Nineveh Province on March 22, 2020. Diagnosis was made by molecular identification of severe acute respiratory syndrome coronavirus-2 by polymerase chain reaction. So , clinical, haematological, and haemoststic parameters should take in account as they are important in determining the severity of the illness and outcome. This study focus on haematological and some haemostatic parameters in 100 cases with …

Evaluating Automatically Generated Normal Tissue Contours For Safe Use In Head And Neck And Cervical Cancer Treatment Planning, Raphael Douglas, Adenike Olanrewaju, Raymond Mumme, Lifei Zhang, Beth M Beadle, Laurence Edward Court

Faculty, Staff and Student Publications

Purpose: Volumetric-modulated arc therapy (VMAT) is a widely accepted treatment method for head and neck (HN) and cervical cancers; however, creating contours and plan optimization for VMAT plans is a time-consuming process. Our group has created an automated treatment planning tool, the Radiation Planning Assistant (RPA), that uses deep learning models to generate organs at risk (OARs), planning structures and automates plan optimization. This study quantitatively evaluates the quality of contours generated by the RPA tool.

Methods: For patients with HN (54) and cervical (39) cancers, we retrospectively generated autoplans using the RPA. Autoplans were generated using deep-learning and RapidPlan …

Autocontouring Of Primary Lung Lesions And Nodal Disease For Radiotherapy Based Only On Computed Tomography Images, Stephen Skett, Tina Patel, Didier Duprez, Sunnia Gupta, Tucker Netherton, Christoph Trauernicht, Sarah Aldridge, David Eaton, Carlos Cardenas, Laurence E Court, Daniel Smith, Ajay Aggarwal

Faculty, Staff and Student Publications

Background and purpose: In many clinics, positron-emission tomography is unavailable and clinician time extremely limited. Here we describe a deep-learning model for autocontouring gross disease for patients undergoing palliative radiotherapy for primary lung lesions and/or hilar/mediastinal nodal disease, based only on computed tomography (CT) images.

Materials and methods: An autocontouring model (nnU-Net) was trained to contour gross disease in 379 cases (352 training, 27 test); 11 further test cases from an external centre were also included. Anchor-point-based post-processing was applied to remove extraneous autocontoured regions. The autocontours were evaluated quantitatively in terms of volume similarity (Dice similarity coefficient [DSC], surface …

Dynamic Stem-Loop Extension By Pol Θ And Templated Insertion During Dna Repair, Denisse Carvajal-Maldonado, Yuzhen Li, Mark Returan, April M Averill, Sylvie Doublié, Richard D Wood

Faculty, Staff and Student Publications

Theta-mediated end joining (TMEJ) is critical for survival of cancer cells when other DNA double-stranded break repair pathways are impaired. Human DNA polymerase theta (Pol θ) can extend ssDNA oligonucleotides, but little is known about preferred substrates and mechanism. We show that Pol θ can extend both ssDNA and RNA substrates by unimolecular stem-loop synthesis initiated by only two 3' terminal base pairs. Given sufficient time, Pol θ uses alternative pairing configurations that greatly expand the repertoire of sequence outcomes. Further primer-template adjustments yield low-fidelity outcomes when the nucleotide pool is imbalanced. Unimolecular stem-loop synthesis competes with bimolecular end joining, …

Combination Therapy With Novel Agents For Acute Myeloid Leukaemia: Insights Into Treatment Of A Heterogenous Disease, Wei-Ying Jen, Hagop Kantarjian, Tapan M Kadia, Courtney D Dinardo, Ghayas C Issa, Nicholas J Short, Musa Yilmaz, Gautam Borthakur, Farhad Ravandi, Naval G Daver

Faculty, Staff and Student Publications

The treatment landscape of acute myeloid leukaemia (AML) is evolving rapidly. Venetoclax in combination with intensive chemotherapy or doublets or triplets with targeted or immune therapies is the focus of numerous ongoing trials. The development of mutation-targeted therapies has greatly enhanced the treatment armamentarium, with FLT3 inhibitors and isocitrate dehydrogenase inhibitors improving outcomes in frontline and relapsed/refractory (RR) AML, and menin inhibitors showing efficacy in RR NPM1

Causes And Consequences Of Mitotic Chromosome Missegregation In Human Pluripotent Stem Cells, Chenhui Deng

Dartmouth College Ph.D Dissertations

Mitosis is a fundamental process that ensures the equal distribution of replicated chromosomes, which carry an organism's genetic material, into two daughter cells. The fidelity of mitosis is paramount, as errors in chromosome segregation result in aberrant chromosome numbers, including gains or losses, a state termed aneuploidy. Aneuploidy impacts a broad range of human conditions, including being one of the major hurdles in early human development where it is the primary cause of miscarriages and birth defects. Strikingly, more than 70% of human preimplantation embryos are aneuploid with mitotic chromosome segregation errors being the most common source of aneuploidy. However, …

The Concept Of An Independent Curriculum With An Agrarian Insight In Early Childhood: Perspectives Of Indonesian Teachers, M. Fadlillah, Eka Oktavianingsih, Nurmalisa Lisdayana

The Qualitative Report

The current condition of agriculture in Indonesia shows a decline in productivity. One reason for this decline is the low interest of children and young people in the agricultural sector. For this reason, the introduction and cultivation of a love of agriculture needs to be done from an early age. Schools must design curriculum and learning that is oriented towards agriculture. The independent curriculum implemented in Indonesia provides ample opportunities to develop agrarian insights in schools. This study aimed to discover teachers' views in Indonesia on the concept of an independent curriculum with an agrarian perspective as a medium for …

Wee1 And Cell Size Control In Fission Yeast By The Protein Kinase Cdr2, Rachel Berg-Murante

Dartmouth College Ph.D Dissertations

The mechanisms that govern cell size have long been topics of study in the field of cell biology. In eukaryotic cells this size control is tied to checkpoints, a set threshold of minimum necessary growth linked to cyclin dependent kinase activity regulation. In the fission yeast Schizosaccharomyces pombe, the Cdk1 regulatory network is conserved, and G2/M represents the major size checkpoint. Prior to mitosis, Cdk1 is inhibited by phosphorylation applied by Wee1 during G2 phase. Once S. pombe cells have satisfied the size checkpoint, Cdk1 is activated through dephosphorylation by Cdc25. Wee1 is a dose-dependent regulator of mitotic entry …

Final 2024 Residential Metals Abatement Program (Rmap) Mandan Park Soil Remedial Action Work Plan (Rawp), Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Final 2024 Residential Metals Abatement Program (Rmap) Park Soil Sampling Field Sampling Plan (Fsp) Submittal #13 [Copper Mountain Park], Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Resilience: Understanding The Role Of Coping In A Racialized Society Among Black Women, Danielle Pendarvis

ETD Collection

The present study explored the intricate relationships between race-based stress, coping strategies (Emotion-focused, Problem-focused, Avoidant coping), the Black Superwoman Schema, resilience, and health outcomes among Black women. Employing a mixed-methods design, an online survey (N = 97) and in-depth semi-structured interviews (N = 10) were conducted, with five transcripts selected for detailed thematic analysis. Quantitative results revealed significant relationships between race-based stress, coping strategies, and adherence to the Black Superwoman Schema. Specifically, race-based stress predicted lower levels of general health, while adherence to the Black Superwoman Schema was associated with diverse coping strategies and higher levels of race-based resilience. Moderation …

Exploring The Relationships Between Food Insecurity, Wic Participation, Early Life Feeding Practices, Diversity Of Dietary Exposures, And Diet Quality In The First Two Years Of Life, Vivian M. Drewelow

Master's Theses

Diet quality during early childhood is a strong predictor of mental and physical outcomes, as well as future diet quality. Although many factors determine diet quality during childhood, food insecurity is a significant predictor of lower diet quality. On the other hand, participation in nutrition assistant programs, such as the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a significant predictor of higher diet quality. In addition, specific feeding practices, including timing of complementary food and beverage (CFB) introduction, types of CFB introduced early, and diversity of dietary exposures (DD), in the first year may predict future …

Annual Seqra Review: Project Applicants Winning More Cases, Michael B. Gerrard

Faculty Scholarship

New York courts are showing impatience with local governments that withhold or stretch out approval of projects without valid environmental grounds. In seven cases last year under the State Environmental Quality Review Act (SEQRA),courts overturned municipal actions that rejected projects or delayed approvals. In all, the courts decided 46 cases under SEQRA in 2023. Where the government agency had decided that an environmental impact statement (EIS) was not needed, that choice was upheld in 23 cases and overturned in eight. Where an EIS had been prepared, the EIS was upheld in 11 and found inadequate in only one. The remaining …

Comparison Of The Sleep Quality Of Undergraduate Training Staff In The Strong Survivors Exercise Program For Cancer Patients And Caregivers And A Control Group Of Undergraduate Students Not Involved In The Program, Amirmohammad Babaniamansour

Research Papers

No abstract provided.

Mda Services: Five Tips To Recruit, Retain Good Employees, Reva Darling

The Journal of the Michigan Dental Association

In a competitive labor market, retaining and recruiting dental staff is challenging. Key strategies include offering health insurance, pre-tax benefit options, and retirement plans, which attract long-term employees. Providing vision insurance and discounts on auto and home insurance can further enhance employee satisfaction. Updating pay scales and utilizing temporary services like Stynt can also aid in filling staff positions.

Beyond The Classroom Volume 11 July 2024 - Athlos And Arete, Students Affairs And Services Pakistan

Student Affairs and Services (SAS) - Beyond the Classroom Archives

• Global Orientations Week
• AKU Sports Olympiad 2024
• Open Discussion with Student Executive Council
• Meeting Between Vice Provost and AKUSA
• Mini Marathon for Heart Health
• AKU Rowing Club hosts inaugural Rowing Regatta
• Workshop on Supporting Student Well-Being
• Promoting Gender Equality at AKU
• IED Students and MC Residents Connect
• Student Representative attends ICM Conference
• First-Ever TEDx Event at AKU
• Managing Stress for PGME Residents
• Suicide Prevention Day Event
• Student Meeting with Leadership
• Mental Health Symposium
• Farewell Celebration for the EN-RN Class of 2024
• International Self-Care Day Celebration
• Trivia Night
• Branding Yourself with Dr. Fahad Mirza
• Conflict Resolution Workshop
• BScN 2024 Tours Heritage …

Contributors

DLSU Business & Economics Review

No abstract provided.

Spatial And Abiotic Effects Of Urbanization On Small Mammal Communities, Bri Casement

Master's Theses

Urbanization, the phenomenon of increasing human population density and artificial structures, is known to decrease the richness, abundance, and diversity of native wildlife populations, fragment natural areas, and increase human and human-commensal animal interactions with wildlife. Dynamics of species persistence in habitat fragments is often understood in the framework of island biogeography theory (IBT), with habitat fragments being analogous to oceanic islands. Despite the conceptual similarities between oceanic islands in IBT and urbanized habitat fragments (fragment size, fragment age, and distance to immigration sources), there are important differences. In urban fragments, the matrix is not completely impassible, habitats within fragments …

Characterization And Evaluation Of Bacteriophages Φpa-C And Φpa-Tc Infecting Pseudomonas Aeruginosa, Joanne Harrison

Master's Theses

Pseudomonas aeruginosa are prevalent opportunistic bacterial pathogens that cause nosocomial infections in at-risk individuals. The rise of multidrug-resistant P. aeruginosa poses an immense threat to hospitals. Additionally, P. aeruginosa are common food spoilage organisms that contribute to food waste. Alternative effective treatment methods are needed to improve public health and reduce food waste. Recent studies have shown that bacteriophages, viruses that only kill host-specific bacteria, are promising alternatives. This study characterizes two lytic P. aeruginosa phages, ΦPa-C and ΦPa-Tc, and evaluates their efficacy against P. aeruginosa in two model food systems. The morphology, genome, structural proteins, host range, growth kinetics, …

Communication, Electrodes, Appropriateness Setup, And Education (Cease) Bundle Implementation In The Surgical Intensive Care Unit, Tina J. Garcia Miller

All Doctor of Nursing Practice (DNP) Scholarly Projects

An estimated 85-99% of alarms in the intensive care unit (ICU) do not require nursing intervention. This overabundance of non-actionable alarms can contribute to sensory overload and is a significant factor in alarm-related safety events. The aim of this project was to reduce the prevalence of non-actionable alarms through the implementation of an evidence-based alarm management bundle. The CEASE Bundle, a comprehensive five-step protocol encompassing Communication, Electrodes, Appropriateness, Setup, and Education, was implemented in an 11-bed surgical intensive care unit. Continuous alarm data was collected for 12 weeks before and 12 weeks after the implementation of the bundle for comparative …

Managing The Relationship Between Hispanic Voters And The State Of Florida: A Quantitative Survey Analysis, Selena M. Gonzalez

USF Tampa Graduate Theses and Dissertations

In recent years, the relationship between registered voters of minority groups and the government of the states they reside in has become increasingly complex due to controversial legislation proposed and often passed in these states. Specifically, some states have passed laws that make it more difficult for Hispanic/Latinx residents to live and work. In particular, Florida has enacted legislation that makes it more difficult for members of the minority groups to vote, drive, and gain access to healthcare. Much of this legislation impacts the Hispanic/Latinx community, which can influence perceptions of the relationship this racial minority has with Florida’s state …

Teachers' And School Directors' Perceptions Of The Benefits Of Arts-Integrated Instruction K-2: Before, During, And After Covid-19, Alison H. Mehler

USF Tampa Graduate Theses and Dissertations

The purpose of this study is to explore the experiences and perceptions of teachers who use arts-integrated instruction and their directors of K-2 students before, during, and after the unique period of online instruction during the COVID-19 pandemic, which began in March of 2020. Arts integration is a method of teaching in which students are taught comprehension of subject areas (i.e. – math, science, reading, social studies) through art forms. These art forms include music, theatre, dance, art, and writing. I collected he qualitative data for this research through virtual interviews with five female participants. I transcribed these interviews and …

Volume 33, Number 2, Summer/Fall 2024, Office Of Communications, Illinois Wesleyan University

Illinois Wesleyan University Magazine, 2018-present

VOLUME 33 | NUMBER 2 | Summer/Fall 2024

ON OUR COVER:

President Sheahon Zenger poses for a portrait in the Bates & Merwin Reading Room on the fourth floor of The Ames Library. The room hosts a collection of award-winning books in honor of IWU's former president Minor Myers jr.

18 Discoveing Home, As a career university administrator with a long record of success and optimism for the future of liberal arts, Sheahon Zenger has been appointed the 21st president of Illinois Wesleyan University.

22 Browadway Reunion, More than a decade after last performing together at IWU, Bry Parham '07 …

Improvement Of Triboelectric Nanogenerator By As-Prepared Lithium Niobate For Energy Harvesting And Sensing Applications, Jahid Inam Chowdhury

Theses and Dissertations

One readily available green energy source that is used to address the small-scale energy requirement is mechanical energy. To harvest mechanical energy, supply energy for upcoming electronic devices, and enable flexible health monitoring, triboelectric nanogenerators composed of perovskite and lightweight polymers have garnered significant interest. A material named lithium niobate (LiNbO3) was produced in two different phases and used to make a flexible triboelectric nanogenerator (TENG). Furthermore, lightweight polydimethylsiloxane (PDMS), Polyvinyl Alcohol (PVA), and LiNbO3 nanoparticles were used to produce a small triboelectric nanogenerator that successfully converts mechanical energy into electricity. LiNbO3 nanoparticles were first created and loaded into polydimethylsiloxane …