Digital Commons Network^™

Where Are We Now With Oncolytic Viruses In Melanoma And Nonmelanoma Skin Malignancies?, George Nassief, Angela Anaeme, Karen Moussa, David Chen, George Ansstas

2020-Current year OA Pubs

Skin cancer prognosis has greatly improved recently due to the introduction of immune checkpoint inhibitors (ICIs). However, many patients with advanced skin cancer still experience immunotherapy resistance and disease progression during ICI treatment, thus calling for novel therapeutics which address this treatment gap. Talimogene laherparepvec (T-VEC) has gained popularity in recent years as a viable treatment option for patients with skin cancer. In preclinical studies, T-VEC demonstrated both a direct anti-tumor effect in injected lesions as well as a systemic immune-mediated effect in non-injected lesions, which could pose additional benefits when combined with ICI therapy. Following promising results from the …

Defining Primary Refractory Large B-Cell Lymphoma, Allison M Bock, Brad S Kahl, Et Al.

2020-Current year OA Pubs

Patients with large B-cell lymphoma (LBCL) that fail to achieve a complete response (CR) or who relapse early after anthracycline-containing immunochemotherapy (IC) have a poor prognosis and are commonly considered to have "primary refractory disease." However, different definitions of primary refractory disease are used in the literature and clinical practice. In this study, we examined variation in the time to relapse used to define refractory status and association with survival outcomes in patients with primary refractory LBCL in a single-center prospective cohort with validation in an independent multicenter cohort. Patients with newly diagnosed LBCL were enrolled in the Molecular Epidemiological …

Displace Study Shows Poor Quality Of Transcranial Doppler Ultrasound For Stroke Risk Screening In Sickle Cell Anemia, Kimberly A Davidow, Robin E Miller, Shannon M Phillips, Alyssa M Schlenz, Martina Mueller, Monica L Hulbert, Lewis L Hsu, Neha Bhasin, Robert J Adams, Julie Kanter

2020-Current year OA Pubs

Children with sickle cell anemia (SCA) are at increased risk of stroke when compared with their age-based counterparts. The Stroke Prevention Trial in Sickle Cell Anemia (STOP) previously demonstrated that with the use of transcranial Doppler ultrasound (TCD; Sickle Stroke Screen) and chronic red cell transfusion, the risk of stroke is reduced by over 90%. The STOP criteria detailed the type and method of measurement required; the time-averaged mean maximum velocity (TAMMV). Unfortunately, it has been difficult to adhere to the appropriate TAMMV measurements. The objectives of this study were to assess the quality of TCD and transcranial Doppler imaging …

Unraveling Facets Of Mecom-Associated Syndrome: Somatic Genetic Rescue, Clonal Hematopoiesis, And Phenotype Expansion, Parvathy Venugopal, Kelly L Bolton, Et Al.

2020-Current year OA Pubs

No abstract provided.

The Cns Relapse In T-Cell Lymphoma Index Predicts Cns Relapse In Patients With T- And Nk-Cell Lymphomas, Rahul S Bhansali, Neha Mehta-Shah, Et Al.

2020-Current year OA Pubs

Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relapse from 19 North American institutions. After exclusion of leukemic and most cutaneous forms of MTNKNs, patients were pooled with non-CNS relapse control patients from a single institution to create a CNS relapse-enriched training set. …

Progenitors Of Distinct Lineages Shape The Diversity Of Mature Type 2 Conventional Dendritic Cells, Patrick Fernandes Rodrigues, Tihana Trsan, Grozdan Cvijetic, Darya Khantakova, Santosh K Panda, Zhaoyuan Liu, Florent Ginhoux, Marina Cella, Marco Colonna

2020-Current year OA Pubs

Conventional dendritic cells (cDC) are antigen-presenting cells comprising cDC1 and cDC2, responsible for priming naive CD8

From Cnns To Transformers In Multimodal Human Action Recognition: A Survey, Muhammad Bilal Shaikh, Douglas Chai, Syed Muhammad Shamsul Islam, Naveed Akhtar

Research outputs 2022 to 2026

Due to its widespread applications, human action recognition is one of the most widely studied research problems in Computer Vision. Recent studies have shown that addressing it using multimodal data leads to superior performance as compared to relying on a single data modality. During the adoption of deep learning for visual modelling in the past decade, action recognition approaches have mainly relied on Convolutional Neural Networks (CNNs). However, the recent rise of Transformers in visual modelling is now also causing a paradigm shift for the action recognition task. This survey captures this transition while focusing on Multimodal Human Action Recognition …

Utilizing Biosimilars To Help Increase Patients Access And Minimize The Financial Burden Of Health Care System In Egypt, Doaa M. Abd-El-Rady, Iman A. El-Baraky, Samar F. Farid

Bulletin of Faculty of Pharmacy Cairo University

Background: Biologics have provided enhanced clinical advantages, but at expense of enormous expenditures. The exorbitant expense of biologics was somewhat mitigated by the development of biosimilars. But biosimilars market access is still recessed in many countries including Egypt. To achieve biosimilars market sustainability, countries need to evaluate the health economic barriers that biosimilars face in gaining market access.

Methods: A retrospective budget impact analysis was conducted to compare the cost of biosimilars to that of their reference biologics from Egyptian regulatory perspective over a five-year period (2018-2022). Time series forecasting analysis was conducted to predict the cost savings …

Removal Of Textile Dyes By Ecofriendly Aquatic Plants From Wastewater: A Review On Plants Species, Mechanisms, And Perspectives, Manal M. El-Sadaawy, Nancy S. Agib

Blue Economy

Water, an essential resource for sustaining life on our planet, is crucial for both human beings and the overall ecosystem. However, in recent decades, several factors, including population growth, rapid industrialization, urbanization, and unsustainable utilization of natural resources, have significantly impacted the quality of water. Industries such as textiles, leather tanning, cosmetics, and pigmentation extensively employ colored compounds called dyes for various purposes. Synthetic dyes have largely replaced natural dyes due to their superior durability against washing, heat, light, pH, and exposure to biological agents. Azo dyes, sulfur dyes, and pigment dyes are some examples of dyes used in industrial …

Beef Production From Grazed Grass And Grass/Clover Swards, Edward G. O'Riordan

IGC Proceedings (1977-2023)

grazed grass (fertiliser nitrogen treated) and grass/clover swards, during two grazing seasons which extended from early-April until mid-November. Both permanent (Treatments A, B and C) and reseeded (Treatment D, E and F) swards were respectively stocked with 3000, 2500 and 2000 kg liveweight/ha in Spring using fifteen steers/treatment (liveweight = 570kg/head). There were small and generally non-significant treatment effects on final liveweight in both years, but heavier carcasses were observed on the reseeded swards (P<0.05). Clover based swards (Treatments B, C and E, F) produced heavier carcasses (P<0.05) than the nitrogen fertilised grass swards (Treatments A and D). Pasture production ranged from 7540 to 10,469 and from 6360 to 11,606 kg DM/ha in year 1 and 2 respectively, with highest yields being observed on the nitrogen fertilised treatment and on the reseeded swards.

Zea Mays Grazing In Cattle Production Systems, V Mundy, B E. Anderson, T L. Gompert, T L. Mader, C A. Shapiro

IGC Proceedings (1977-2023)

Nebraska producers have used silage maize (Zea mays L.) hybrids as a grazed forage in dairy and beef production systems. In an onfarm case study, farmers and researchers collaborated to gather information on production practices, grazing management, and plant characteristics of grazing maize within three forage-based dairy and beef systems. Production practices were generally similar to conventional grain corn production, except that in one system maize was seeded directly into a suppressed grass sod. Milk production from grazing maize was 23 kg/day/animal, compared to 24 kg/day/ animal before using maize and 22 kg/day/animal after using maize. Average gain of …

Wildcat, Karl Martin

Journal of Religion & Film

This is a film review of Wildcat (2023), directed by Ethan Hawke.

Journal Of Educational Leadership In Action, Volume 9, Issue 2, Full Issue, Lindenwood University

Journal of Educational Leadership in Action

No abstract provided.

Thai Americans: A Poem Collection Featuring "Bilingual หมา Standard Poodle" And "Last Name กู Too Long", Simon Boonsripaisal, Ravadee Boonsripaisal

Journal of Southeast Asian American Education and Advancement

This is a co-authored poem collection focusing on Thai American life. In Bilingual หมา Standard Poodle, interactions and observations are made between a Thai American family and their supportive standard poodle named Pumpkin. This poem interjects on the disaggregated Southeast Asian American experience with inclusion of a pet companion. In Last Name กู Too Long, a Thai American graduate student discusses with their mother the challenges of gaining employment. This poem brings attention to hiring bias in the screening and interview process.

Supporting Student Success In The Classroom: Creating A Socio-Emotional Healthy Environment For University Students, Amonda Matthewman-Isgrigg

Journal of the Scholarship of Teaching and Learning for Christians in Higher Education

Through the use of Astin’s IEO Model, Socio-Emotional Intelligence (SEI), and Maslow’s Hierarchy of Needs, this paper acknowledges college and university students’ academic and emotional needs and seeks to address the needs of current and future university students to have a supportive classroom environment as they earn their degrees. As the primary focus is on students, the well-being and training of instructors need to be addressed as well because they are the front line of the student support system. By analyzing the pre-existing inputs of the students, being the emotional and mental well-being of the student identified through Maslow’s Hierarchy …

Full Text

Journal of the Scholarship of Teaching and Learning for Christians in Higher Education

No abstract provided.

Cyclical Interest In Entrepreneurship And The Virginia Economy, Daniel Farhat

Journal of Business & Entrepreneurship

This study uses keyword search data from Google to construct an index representing broad interest in entrepreneurship in Virginia. Dynamic correlations are evaluated to identify how short-term movements in the index relate to employment and earnings, leading economic indicators, home prices and business applications. Results support opportunity-driven mindsets in the labor market but not in the real estate market. The index is shown to have some economic prediction power, and is capable of producing new insights compared to data from actual business activity. This study highlights the role entrepreneurial interest may play in policy and lays the groundwork for further …

Career Preferences Of Business Students: Traditional Career Path Or Entrepreneurship And Self-Employment?, David W. Whitlock, Ashley J. Hampton, Shanker Menon

Journal of Business & Entrepreneurship

Factors influencing career preferences of business students are explored. This study builds upon an original research project conducted in 1995, which focused on comparing pursuits of entrepreneurship versus more traditional business employment as career paths for business students. In the present study, 40 students enrolled in the senior-level capstone business course and 26 students enrolled in the freshman-level introductory business course in an AACSB accredited business school were administered surveys to determine career preferences and the factors influencing those preferences. The results of the introductory-level course are compared to those of students in the senior-level capstone business course and reported. …

Epicardial Pacemaker Causing Cardiac Strangulation, ​​Ian Scott ​ Kendall​, ​​Rihab ​ ​​Agouba​, Andrew Sands, ​​Frank ​ ​​Casey ​, Lars ​ Nolke ​

Journal of the Saudi Heart Association

Cardiac strangulation is a rare but potentially lethal complication of epicardial pacemaker insertion. We present the case of a 9-year-old girl who was identified as having cardiac strangulation on routine follow-up for an epicardial pacemaker inserted on day 1 of life for congenital complete heart block (CCHB). The clinical presentations and risk factors for pacemaker strangulation is then discussed

Energy Security Of Ukraine: External Threats From The Russian Federation, Valeriia Lymar

Yearbook of Antitrust and Regulatory Studies

A country’s energy security is an important component of its overall national security, as energy supply is essential for the functioning of its national economy and the livelihoods of its population. The purpose of this research is to develop practical tools for analyzing the condition of Ukraine’s energy sector, and to provide practical recommendations for potential development and integration into the single European energy system. The practical value of the research findings is that the SWOT-analysis (Strengths – Weakness – Opportunities – Troubles) of the energy sector of Ukraine which makes it possible to identify the most acute problems and …

Emerging Clean Energy Choices In Canada’S Net-Zero 2050 Transition: The Role Of Nuclear In The Low Carbon And Clean Hydrogen Context, Rudiger Tscherning, Jesse Dias

Yearbook of Antitrust and Regulatory Studies

The paper argues that nuclear energy could play a significant role in decarbonizing the production of low carbon hydrogen from natural gas feedstock with associated carbon storage, as part of a wider shift towards ‘net-zero’ in Canada’s natural resources value chain. It examines regulatory readiness for small modular reactors in the oil, gas, and low-carbon energy sector of Canada’s energy jurisdiction, and calls for the speedy design and development of a single ‘go-to’ regulatory framework for nuclear energy in Alberta.

Résumé
L’article soutient que l’énergie nucléaire pourrait jouer un rôle important dans la décarbonisation de la production d’hydrogène décarboné à …

Eu Energy Solidarity As A Way Of Implementing Just Transition In Energy Policy, Robert Zajdler

Yearbook of Antitrust and Regulatory Studies

The principle of EU energy solidarity, regulated by Article 194 of the Lisbon Treaty, has created a new dimension of energy sector developments. Initially, it was treated as an abstract, purely political concept with no particular normative significance. However, the CJEU judgment in the OPAL case established energy solidarity as a principle of EU law, deriving, inter alia, from the principle of justice. The concept of just transition, based on the same foundations of justice, creates directions for socio-economic transformation based on a sustainable and low-carbon economy. Energy solidarity is, in fact, a way of implementing the assumptions and directions …

The Road To Energy Justice As A Result Of Interdisciplinary Cooperation In The Energy Policy Field, Michał Domagała, Katarzyna Maćkowska

Yearbook of Antitrust and Regulatory Studies

This article pertains to the role of law in regulating the energy market. Justice and solidarity in this area require a debate that should not be fragmented but must, instead, take place in an interdisciplinary manner. The key question that arises relates to the role that the law should play in the area of energy transformation, and thus, whether it should only be a tool for the implementation of political plans and action strategies, or whether it should, in itself, stimulate or determine the transition framework, or be a regulator of transformation. The article tackles selected problems related to Demand …

Online Intermediaries And Sustainable Market Regulation – A Smart Mix Of Liability And Exemptions, Katarzyna Klafkowska-Waśniowska, Katja Weckström

Yearbook of Antitrust and Regulatory Studies

The Commission has advanced sustainable and responsible behaviour of business operators in the digital environment since the adoption of the Strategy for the Digital Single Market of 2015. The question remains, how can we reach the normative goal of ensuring a safe, secure and fair online environment, where fundamental rights are protected, and responsibilities of platforms, especially large players and gatekeepers, are well defined? A “smart mix” of mandatory and voluntary rules, in combination with industry self regulation, is applied to address business and fundamental rights. This paper asks how the Digital Services Act (DSA) answers the call for sustainable …

“The Role Of Modern Technologies In Effective Management Of Crowds”, Ayman El-Din

Journal of Police and Legal Sciences

Scientists started to think about the importance of developing crowd management methods, because of human gatherings - in different countries - have been accompanied by lots of disasters that have killed many and resulted in many injuries. Gathering crowd data is vital in the process of managing crowds, as crowd information contributes significantly to planning and decision-making processes and increasing communication between parties interacting with them, and data collected includes "the number of crowd members, crowd density, and problems that may occur”. Technology and technical awareness play an important role in “collecting, organizing, analyzing” real-time collected data of crowd. This …

Coastal Infrastructure And Climate Change Adaptation In Bangladesh: Ecosystem Services Insights From An Integrated Ses-Dapsir Framework, Md Monzer Hossain Sarker, Alberto Gabino Martínez-Hernández, Jesús Reyes Vásquez, Perla Rivadeneyra, Sebastian Sebastian Raimondo

Fondazione Eni Enrico Mattei Working Papers

The escalating impacts of climate change on coastal regions stress the urgency for effective adaptation strategies, particularly for the case of high-risk countries such as Bangladesh. Nature-based solutions, grey and mixed coastal infrastructure offer promising solutions for addressing these challenges. Prior publications have utilized decision-making models such as the DPSIR framework to explore the link between coastal infrastructure and climate change. However, until now none of them have used it in combination with broader frameworks. Moreover, few works have analyzed the south central coast of Bangladesh by following an integrated approach. Hence, this working paper aims to bridge these gaps …

Ada News - 07/08/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Mental Health Hospitalizations In Canadian Children, Adolescents, And Young Adults Over The Covid-19 Pandemic, Saptharishi Lalgudi Ganesan

Data and Test Instruments

ImportanceThe COVID-19 pandemic resulted in multiple socially restrictive public health measures and reported negative mental health impacts in youths. Few studies have evaluated incidence rates by sex, region, and social determinants across an entire population.ObjectiveTo estimate the incidence of hospitalizations for mental health conditions, stratified by sex, region, and social determinants, in children and adolescents (hereinafter referred to asyouths) and young adults comparing the prepandemic and pandemic-prevalent periods.Design, Setting, and ParticipantsThis Canadian population-based repeated ecological cross-sectional study used health administrative data, extending from April 1, 2016, to March 31, 2023. All youths and young adults from 6 to 20 years …

Pandemic Stringency Measures And Hospital Admissions For Eating Disorders, Saptharishi Lalgudi Ganesan

Data and Test Instruments

IMPORTANCE Hospitalizations for eating disorders rose dramatically during the COVID-19pandemic. Public health restrictions, or stringency, are believed to have played a role inexacerbating eating disorders. Few studies of eating disorders during the pandemic haveextended to the period when public health stringency restrictions were lifted.OBJECTIVE To assess the association between hospitalization rates for eating disorders andpublic health stringency during the COVID-19 pandemic and after the easing of public healthrestrictions.DESIGN, SETTING, AND PARTICIPANTS This Canadian population-based cross-sectional studywas performed from April 1, 2016, to March 31, 2023, and was divided into pre–COVID-19 andCOVID-19–prevalent periods. Data were provided by the Canadian Institute for …

Office Of Equity And Inclusion Newsletter - July 2024, Office Of Equity And Inclusion, East Tennessee State University

Office of Equity and Inclusion Newsletters

No abstract provided.