Digital Commons Network^™

Incidence And Types Of Cardiac Arrhythmias In The Peri-Ictal Period In Patients Having A Generalized Convulsive Seizure, Laura Vilella, Christina Y Miyake, Ganne Chaitanya, Johnson P Hampson, Shirin Jamal Omidi, Manuela Ochoa-Urrea, Blanca Talavera, Oscar Mancera, Norma J Hupp, Jaison S Hampson, M R Sandhya Rani, Nuria Lacuey, Shiqiang Tao, Rup K Sainju, Daniel Friedman, Maromi Nei, Catherine A Scott, Brian Gehlbach, Stephan U Schuele, Jennifer A Ogren, Ronald M Harper, Beate Diehl, Lisa M Bateman, Orrin Devinsky, George B Richerson, Guo-Qiang Zhang, Samden D Lhatoo

Faculty, Staff and Students Publications

Background and objectives: Generalized convulsive seizures (GCSs) are the main risk factor of sudden unexpected death in epilepsy (SUDEP), which is likely due to peri-ictal cardiorespiratory dysfunction. The incidence of GCS-induced cardiac arrhythmias, their relationship to seizure severity markers, and their role in SUDEP physiopathology are unknown. The aim of this study was to analyze the incidence of seizure-induced cardiac arrhythmias, their association with electroclinical features and seizure severity biomarkers, as well as their specific occurrences in SUDEP cases.

Methods: This is an observational, prospective, multicenter study of patients with epilepsy aged 18 years and older with recorded GCS during …

Cotargeting Ebv Lytic As Well As Latent Cycle Antigens Increases T-Cell Potency Against Lymphoma, Sandhya Sharma, Naren U Mehta, Tim Sauer, Lisa A Rollins, Dirk P Dittmer, Cliona M Rooney

Faculty, Staff and Students Publications

The remarkable efficacy of Epstein-Barr virus (EBV)-specific T cells for the treatment of posttransplant lymphomas has not been reproduced for EBV-positive (EBV+) malignancies outside the transplant setting. This is because of, in part, the heterogeneous expression and poor immunogenicity of the viral antigens expressed, namely latent membrane proteins 1 and 2, EBV nuclear antigen 1, and BamHI A rightward reading frame 1 (type-2 [T2] latency). However, EBV lytic cycle proteins are also expressed in certain EBV+ malignancies and, because several EBV lytic cycle proteins are abundantly expressed, have oncogenic activity, and likely contribute to malignancy, we sought and identified viral …

Developing The Openflexure Microscope Towards Medical Use: Technical And Social Challenges Of Developing Globally Accessible Hardware For Healthcare, Joe Knapper, Freya Whiteford, Daniel Rosen, William Wadsworth, Julian Stirling, Catherine Mkindi, Joram Mduda, Valerian L Sanga, Paul T Nyakyi, Thomas Hervé Mboa Nkoudou, Elisée Jafsia, Stephane Fadanka, Kelsey Hummel, Sharmila Anandasabapathy, Richard Bowman

Faculty, Staff and Students Publications

The OpenFlexure Microscope is an accessible, three-dimensional-printed robotic microscope, with sufficient image quality to resolve diagnostic features including parasites and cancerous cells. As access to lab-grade microscopes is a major challenge in global healthcare, the OpenFlexure Microscope has been developed to be manufactured, maintained and used in remote environments, supporting point-of-care diagnosis. The steps taken in transforming the hardware and software from an academic prototype towards an accepted medical device include addressing technical and social challenges, and are key for any innovation targeting improved effectiveness in low-resource healthcare. This article is part of the Theo Murphy meeting issue 'Open, reproducible …

Tfeb Safeguards Trophoblast Syncytialization In Humans And Mice, Wanshan Zheng, Yue Zhang, Peiqun Xu, Zexin Wang, Xuan Shao, Chunyan Chen, Han Cai, Yinan Wang, Ming-An Sun, Wenbo Deng, Fan Liu, Jinhua Lu, Xueqin Zhang, Dunjin Cheng, Indira U Mysorekar, Haibin Wang, Yan-Ling Wang, Xiaoqian Hu, Bin Cao

Faculty, Staff and Students Publications

The formation of multinucleated syncytiotrophoblast (STB) through cell fusion of cytotrophoblast, also termed syncytialization, ensures the proper placental structure and functions. Nutrient insufficiency and inactivation of the mechanistic target of rapamycin complex 1 (mTORC1) in trophoblasts have been shown to enhance STB formation; however, the underlying mechanism remains elusive. Here, we showed that the deficiency of a mTORC1 downstream transcriptional factor, TFEB, significantly impaired STB formation in human trophoblasts and knock-out mice. TFEB conferred direct transcriptional activation of the fusogen ERVFRD-1 and thereby promoted trophoblast syncytialization. Additionally, TFEB expression positively correlated with the reinforced trophoblast syncytialization in human fetal growth …

20240709: Information Technology Administration, Allen Taylor Files, 1989-2020, Information Technology

Guides to University Archives

These items include materials from the Administration within Information Technology at Marshall University from 1989-2020. Items were received in 2024 and include notable materials from the office of Allen Taylor. This is not an exhaustive list, but the attached inventory will give a broad overview of what is contained in each of the boxes...with a folder-level description when possible.

Exploring The Social Processes Influencing The Well-Being And Social Integration Of Systemically Marginalized Students In Higher Education: A Mixed-Methods Approach, Zeinab Abbas Hachem

Dissertations and Theses

Comprising two manuscripts, this dissertation employs a mixed-methods approach to comprehensively examine the intrapersonal and interpersonal processes influencing the socioemotional well-being and social integration of systemically marginalized students. The first manuscript quantitatively explored the relationship between ethnic identity commitment and indices of well-being, the mediating role of social relationships, and the moderating roles of gender and immigrant generation status among Latinx college students (N = 707). Results suggested that ethnic identity commitment was positively associated with socioemotional well-being. Although both types of relationships were significant mediators on their own, maternal (vs. peer) relationship quality was the stronger mediational influence. Furthermore, …

Persistent Interruption In Parvalbuminpositive Inhibitory Interneurons: Biophysical And Mathematical Mechanisms, Carol M. Upchurch, Christopher J. Knowlton, Simon Chamberland, Carmen C. Canavier

School of Graduate Studies Faculty Publications

Persistent activity in excitatory pyramidal cells (PYRs) is a putative mechanism for maintaining memory traces during working memory. We have recently demonstrated persistent interruption of firing in fastspiking parvalbumin-expressing interneurons (PV-INs), a phenomenon that could serve as a substrate for persistent activity in PYRs through disinhibition lasting hundreds of milliseconds. Here, we find that hippocampal CA1 PV-INs exhibit type 2 excitability, like striatal and neocortical PV-INs. Modeling and mathematical analysis showed that the slowly inactivating potassium current KV1 contributes to type 2 excitability, enables the multiple firing regimes observed experimentally in PV-INs, and provides a mechanism for robust persistent interruption …

Adjunctive Therapy With An Oral H2s Donor Provides Additional Therapeutic Benefit Beyond Sglt2 Inhibition In Cardiometabolic Heart Failure With Preserved Ejection Fraction, Jake E. Doiron, Huijing Xia, Xiaoman Yu, Alexandra R. Nevins, Kyle B. Lapenna, Thomas E. Sharp, Traci T. Goodchild, Timothy D. Allerton, Mona Elgazzaz, Eric Lazartigues, Sanjiv J. Shah, Zhen Li, David J. Lefer

School of Graduate Studies Faculty Publications

Background and Purpose: Sodium glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a potent therapy for heart failure with preserved ejection fraction (HFpEF). Hydrogen sulphide (H2S), a well-studied cardioprotective agent, could be beneficial in HFpEF. SGLT2i monotherapy and combination therapy involving an SGLT2i and H2S donor in two preclinical models of cardiometabolic HFpEF was investigated. Experimental Approach: Nine-week-old C57BL/6N mice received L-NAME and a 60% high fat diet for five weeks. Mice were then randomized to either control, SGLT2i monotherapy or SGLT2i and H2S donor, SG1002, for five additional weeks. Ten-week-old ZSF1 obese rats were randomized to control, SGLT2i or …

Canine Hepatocellular Carcinoma: Evaluating Pgam5 And Heterobilharzia Americana, Priscilla Devora

LSU Doctoral Dissertations

Hepatocellular carcinoma (HCC) is the most common primary liver cancer in humans and domestic dogs. Despite extensive research, the mechanisms that drive HCC carcinogenesis and perpetuate cancer survival are incompletely understood in both species. The work described herein focused on finding similarities between canine and human HCC, which could be harnessed to benefit humans and dogs with cancer. The first aim was to investigate the expression of phosphoglycerate mutase 5 (PGAM5) in canine HCC. Upregulation of PGAM5 is a negative prognostic indicator in human HCC. Using archival formalin-fixed paraffin-embedded samples, we found that PGAM5 was overexpressed in canine HCC ( …

Assessing Team Performance And Cohesion Of Isolated Multicultural Teams Using Digital Escape Rooms, Susannah J. Aronson

LSU Doctoral Dissertations

History has shown that when multicultural teams are together for long periods of time, conflict can occur. When put in an isolated environment, these conflicts can become dangerous. This study looked at physically isolated multicultural teams through the lens of systems engineering and if a publicly available escape room video game could measure the team’s individual level team performance and cohesion. The author also evaluated the relationship between these success measures, cultural intelligence, and fusion collaboration. Results showed the escape room video game was a reliable and valid instrument to measure individual level team performance and cohesion. The validity correlation …

Cxcl16-Dependent Scavenging Of Oxidized Lipids By Islet Macrophages Promotes Differentiation Of Pathogenic Cd8+ T Cells In Diabetic Autoimmunity, Neetu Srivastava, Hao Hu, Orion J Peterson, Anthony N Vomund, Marta Stremska, Mohammad Zaman, Shilpi Giri, Tiandao Li, Cheryl F Lichti, Pavel N Zakharov, Bo Zhang, Nada A Abumrad, Yi-Guang Chen, Kodi S Ravichandran, Emil R Unanue, Xiaoxiao Wan

2020-Current year OA Pubs

The pancreatic islet microenvironment is highly oxidative, rendering β cells vulnerable to autoinflammatory insults. Here, we examined the role of islet resident macrophages in the autoimmune attack that initiates type 1 diabetes. Islet macrophages highly expressed CXCL16, a chemokine and scavenger receptor for oxidized low-density lipoproteins (OxLDLs), regardless of autoimmune predisposition. Deletion of Cxcl16 in nonobese diabetic (NOD) mice suppressed the development of autoimmune diabetes. Mechanistically, Cxcl16 deficiency impaired clearance of OxLDL by islet macrophages, leading to OxLDL accumulation in pancreatic islets and a substantial reduction in intra-islet transitory (Tex

Morgs3 Functions In Intracellular Reactive Oxygen Species Perception-Integrated Camp Signaling To Promote Appressorium Formation In Magnaporthe Oryzae, Ruiming Zhang, Xinyu Liu, Jiayun Xu, Chen Chen, Zhaoxuan Tang, Chengtong Wu, Xinyue Li, Lei Su, Muxing Liu, Leiyun Yang, Gang Li, Haifeng Zhang, Ping Wang, Zhengguang Zhang

School of Graduate Studies Faculty Publications

Regulator of G-protein signaling (RGS) proteins exhibit GTPase-accelerating protein activities to govern G-protein function. In the rice blast fungus Magnaporthe oryzae, there is a family of at least eight RGS and RGS-like proteins (MoRgs1 to MoRgs8), each exhibiting distinct or shared functions in the growth, appressorium formation, and pathogenicity. MoRgs3 recently emerged as one of the crucial regulators that senses intracellular oxidation during appressorium formation. To explore this unique regulatory mechanism of MoRgs3, we identified the nucleoside diphosphate kinase MoNdk1 that interacts with MoRgs3. MoNdk1 phosphorylates MoRgs3 under induced intracellular reactive oxygen species levels, and MoRgs3 phosphorylation is required for …

Assessing The Relative Sustainability Of Point-Of-Use Water Disinfection Technologies For Off-Grid Communities, Bright C. Elijah, Ali Ahmad, Yalin Li, Jaime Plazas-Tuttle, Lewis Stetson Rowles

Civil Engineering & Construction: Faculty Publications

Point-of-use (POU) water disinfection technologies can be adopted to provide access to safe drinking water by treating water at the household level; however, navigating various POU disinfection technologies can be difficult. While numerous conventional POU devices exist, emerging technologies using novel materials or advanced processes have been under development and claim to be of lower cost with higher treatment capacity. However, it is unclear if these claims are substantiated and how novel technologies compare to conventional ones in terms of cost and environmental impacts when providing the same service (i.e., achieving a necessary level of disinfection for safe drinking water). …

Training Nurse Practitioners And Providers In Primary Care To Screen For Bipolar Disorder, Jane Ngozi Iwebo

Walden Dissertations and Doctoral Studies

The global spotlight on mental illness has challenged healthcare providers to enhance their assessment and diagnosis of various mental health conditions like Bipolar Affective Disorder. Bipolar Affective Disorder (BPAD) is a serious mental illness characterized by severe mood swings ranging from depression to mania, often leading to high rates of suicide and disability. There is a significant gap of 8-10 years between the initial primary care visit and the diagnosis of BPAD leading to delayed treatment and worsening outcomes. The lack of use and/or knowledge of primary care providers on the use of assessment tools, such as the mood disorder …

Electrocautery Wire Fenestration Prior To Thoracic Endovascular Aortic Repair To Optimize The Distal Landing Zone In Thoracic Aortic Dissections, Nicola Habash, Gaurang Joshi, Mohammed Ali, Michael Nooromid, Babak Abai

Department of Surgery Faculty Papers

Successful thoracic endovascular aortic repair (TEVAR) for type B aortic dissections (TBAD) relies on securing the stentgraft’s distal landing zone to prevent retrograde flow and false lumen pressurization. We describe a 60-year- old male with a TBAD undergoing TEVAR with electrocautery-wire fenestration of the dissection septum, providing a controlled method to enhance the distal landing zone for graft placement. Postoperatively, the patient experienced spinal cord ischemia, resolving with the placement of a lumbar drain and increasing mean arterial pressures. Follow-up imaging demonstrated a well-sealed repair without endoleaks. This case highlights the importance of surgical technique selection and postoperative monitoring for …

Atrocity Prevention In The Digital Era: Adapting Norms, Laws, And Code To Changes In The Ways Atrocities Are Committed, David J. Simon, Samhitha Josyula, Joshua Lam, Julian D. Melendi

Genocide Studies and Prevention: An International Journal

Emerging digital technologies have changed some of the ways that genocides are planned and executed. This paper examines those differences, calling attention to how changes in the execution of genocide should prompt a shift in the approaches to atrocity prevention. It develops a conceptual framework addressing how atrocity prevention efforts might adapt to new technology within three realms of potential prevention efforts: the ethical (norms), the legal (laws), and the digital (code).

Security Or Vulnerability? The Optics Of Data In The Humanitarian Sphere, Nicole M. Bennett, Hamid Ekbia

Genocide Studies and Prevention: An International Journal

Governments, humanitarian agencies, and non-government organizations increasingly resort to data-driven techniques to meet the challenges they face in dealing with growing mobile populations such as refugees. Such techniques originate in bureaucratic administrations of the 19th century and, even earlier, in slave trade and plantation accounting methods. They were then perfected in logistics and global supply chain management of the twentieth and twenty-first centuries, especially with the advent of information technology. We examine the application of these techniques in humanitarian cases, seeking to contextualize them within the framework of logistic security. To understand the drivers of this trend, we introduce the …

Utilization Of Electronic Resources For Effective Library Services In The 21st Century, Stanley Efe Okolo

Library Philosophy and Practice (e-journal)

This paper focuses on the utilization of electronic resources for effective library services in the 21^st century. The research paper treated among others, the concept of electronic database, and the various types of databases that are available in the educational system. It also treated the application of electronic resources or databases in rendering effective library services, factors that must be in place in order for electronic databases to be used for library services which includes: library Automation, library Management, library Networking, Audio-visual Technology and technical Communication. The paper outlined some challenges as enshrined by scholars in the field of …

Symptom Burden, Identity Balance, And Emotional Distress In Cancer Survivors, Lynne Bentley

Dissertations

Emotional distress suffuses the experience of cancer survivors and is associated with adverse outcomes. Emotional distress is a response to a circumstance, which threatens the stability of identity. Of the antecedents to emotional distress in cancer patients, symptom burden accounts for the greatest amount of variance. Qualitative studies in populations of cancer survivors have shown that identity affects the experience of emotional distress related to symptom burden. The purpose of this dissertation research was to measure the relationships among symptom burden, identity balance, and emotional distress by testing whether identity balance mediates the relationship between symptom burden and emotional distress …

Early Identification Of Postpartum Depression Symptoms During The Antenatal Period Using The Edinburgh Postnatal Depression Scale, Cherie Didier

DNP and Student Works

This quantitative quality improvement project aimed to assess the effectiveness of implementing the Edinburgh Postnatal Depression Scale (EPDS) during the prenatal period in an obstetrical clinic in Memphis, TN. The primary research question was to investigate whether prenatal screening for postpartum depression (PPD) using the EPDS is effective in identifying at-risk individuals and improving maternal mental health outcomes.

Breaking The Silence: Autoethnographic Account Of Communication In The Aftermath Of Parental Suicide, Marissa L. Lucero

Communication ETDs

The silence that surrounds the suicide of a parent often masks unresolved feelings of guilt, shame, and powerlessness in families grieving their loss. For children, the long-lasting impact of suppressing communication about parental suicide can endure throughout adulthood. In this autoethnography, I un-salience my voice to reflect on my father’s suicide in the context of my Nuevo Mexicana identity. I assert my Chicana feminist voice through an extraction of gendered and culturally grounded memories, personal journal entries from my childhood, and a review of academic sources on suicide. This thesis is a personal and intellectual engagement with Chicana/o critical theory, …

Cardiovascular Disease In Adults With A History Of Out-Of-Home Care During Childhood: A Systematic Review And Meta-Analysis Of Prospective Cohort Studies, G. David Batty, Mika Kivimäki, Ylva B. Almquist, Johan G. Eriksson, Mika Gissler, Emmanuel S. Gnanamanickam, Mark Hamer, Josephine Jackisch, Hee-Soon Juon, Markus Keski-Säntti, Chaiquan Li, Tuija M. Mikkola, Emily Murray, Amanda Sacker, Leonie Segal, Philipp Frank

Department of Medical Oncology Faculty Papers

Background

While individuals who were separated from their biological family and placed into the care of the state during childhood (out-of-home care) are more prone to developing selected adverse health problems in adulthood, their risk of cardiovascular disease is uncertain. Our aim was to explore this association by pooling published and unpublished results from prospective cohort studies.

Methods

We used two approaches to identifying relevant data on childhood care and adult cardiovascular disease (PROSPERO registration CRD42021254665). First, to locate published studies, we searched PubMed (Medline) until November 2023. Second, with the objective of identifying unpublished studies with the potential to …

Nursing Staff Education On Enhanced Recovery After Surgery Related To Nurse-Patient Pain Communication, Kathleen Ranne

Walden Dissertations and Doctoral Studies

Perioperative pain is a significant challenge in terms of care of surgical patients which requires effective communication by nurses to improve patient outcomes and satisfaction. The communication component of the Enhanced Recovery after Surgery protocol is a foundation for improved patient outcomes and pain management. The problem that was identified in this Doctor of Nursing Practice project was lack of staff education during the perioperative period related to nurse-patient communications regarding pain management. Using the analysis, design, development, implementation, and evaluation model of instructional design, the purpose of this DNP project was to plan, implement, and evaluate a staff education …

A Fungal Metabolic Regulator Underlies Infectious Synergism During Candida Albicans-Staphylococcus Aureus Intra-Abdominal Co-Infection, Saikat Paul, Olivia A. Todd, Kara R. Eichelberger, Christine Tkaczyk, Bret R. Sellman, Mairi C. Noverr, James E. Cassat, Paul L. Fidel, Brian M. Peters

School of Dentistry Faculty Publications

Candida albicans and Staphylococcus aureus are two commonly associated pathogens that cause nosocomial infections with high morbidity and mortality. Our prior and current work using a murine model of polymicrobial intra-abdominal infection (IAI) demonstrates that synergistic lethality is driven by Candida-induced upregulation of functional S. aureus α-toxin leading to polymicrobial sepsis and organ damage. In order to determine the candidal effector(s) mediating enhanced virulence, an unbiased screen of C. albicans transcription factor mutants was undertaken revealing that zcf13Δ/Δ fails to drive augmented α-toxin or lethal synergism during co-infection. A combination of transcriptional and phenotypic profiling approaches shows that ZCF13 regulates …

Research Review: "A Novel Mind-Body Podcast Program For Military And Veteran Caregivers", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This research review discusses how mind-body interventions can alleviate stress and enhance health for caregivers, but they are not widely accessible in many communities. To overcome this limitation, a study converted an 8-week mind-body program into a 28-day daily podcast series featuring education on stress response, relaxation techniques, and self-compassion exercises. The program was tested with 55 military caregivers, all cisgender women averaging 42.3 years old, and evaluations at the start, halfway through, and at the end of the program revealed notable reductions in stress, depression, and physical issues, along with improved social role performance, indicating that a daily mind-body …

Identification Of An H-Ras Nanocluster Disrupting Peptide, Candy Laura Steffen, Ganesh Babu Manoharan, Karolina Pavic, Alejandro Yeste-Vázquez, Matias Knuuttila, Neha Arora, Yong Zhou, Harri Härmä, Anthoula Gaigneaux, Tom N Grossmann, Daniel Kwaku Abankwa

Faculty, Staff and Student Publications

Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane nanoclusters, which are therefore potential drug targets. We previously showed that the nanocluster scaffold galectin-1 (Gal1) enhances H-Ras nanoclustering via direct interaction with the Ras binding domain (RBD) of Raf. Here, we establish that the B-Raf preference of Gal1 emerges from the divergence of the Raf RBDs at their proposed Gal1-binding interface. We then identify the L5UR peptide, which disrupts this interaction by binding with low micromolar affinity to the B- and C-Raf-RBDs. Its 23-mer core fragment is sufficient to interfere with H-Ras nanoclustering, modulate …

The Cns Relapse In T-Cell Lymphoma Index Predicts Cns Relapse In Patients With T- And Nk-Cell Lymphomas, Rahul S Bhansali, Fredrik Ellin, Thomas Relander, Miao Cao, Wenrui Li, Qi Long, Nivetha Ganesan, Robert Stuver, Steven M Horwitz, Kitsada Wudhikarn, Steven R Hwang, N Nora Bennani, Julio Chavez, Lubomir Sokol, Hayder Saeed, Frank Duan, Pierluigi Porcu, Priyanka Pullarkat, Neha Mehta-Shah, Jasmine M Zain, Miguel Ruiz, Jonathan E Brammer, Rishab Prakash, Swaminathan P Iyer, Adam J Olszewski, Ajay Major, Peter A Riedell, Sonali M Smith, Caroline Goldin, Bradley Haverkos, Bei Hu, Tony Z Zhuang, Pamela B Allen, Wael Toama, Murali Janakiram, Taylor R Brooks, Deepa Jagadeesh, Nisha Hariharan, Aaron M Goodman, Gabrielle Hartman, Paola Ghione, Fatima Fayyaz, Joanna M Rhodes, Elise A Chong, James N Gerson, Daniel J Landsburg, Sunita D Nasta, Stephen J Schuster, Jakub Svoboda, Mats Jerkeman, Stefan K Barta

Faculty, Staff and Student Publications

Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relapse from 19 North American institutions. After exclusion of leukemic and most cutaneous forms of MTNKNs, patients were pooled with non-CNS relapse control patients from a single institution to create a CNS relapse-enriched training set. …

Leukocyte Immunoglobulin-Like Receptor B1 (Lilrb1) Protects Human Multiple Myeloma Cells From Ferroptosis By Maintaining Cholesterol Homeostasis, Miao Xian, Qiang Wang, Liuling Xiao, Ling Zhong, Wei Xiong, Lingqun Ye, Pan Su, Chuanchao Zhang, Yabo Li, Robert Z Orlowski, Fenghuang Zhan, Siddhartha Ganguly, Youli Zu, Jianfei Qian, Qing Yi

Faculty, Staff and Student Publications

Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing the urgent need for identifying new therapeutic targets. Here, we show that the leukocyte immunoglobulin-like receptor B1 (LILRB1), a transmembrane receptor conducting negative immune response, is a top-ranked gene associated with poor prognosis in MM patients. LILRB1 deficiency inhibits MM progression in vivo by enhancing the ferroptosis of MM cells. Mechanistic studies reveal that LILRB1 forms a complex with the low-density lipoprotein receptor (LDLR) and LDLR adapter protein 1 (LDLRAP1) to facilitate LDL/cholesterol …

Prevalence Of Dermatological Conditions Among Patients With Diabetic Neuropathy In The Rio Grande Valley: A Retrospective Analysis, Jared Hensley, Blake Martin, Chloe C. Harris, Kelsey Baker

School of Medicine Publications

Background: Diabetic neuropathy, a common complication of diabetes, predisposes patients to various secondary health issues, including dermatological conditions. This study investigates the prevalence and types of skin conditions (ICD-10 codes L00-L99) among patients with diabetic neuropathy within a South Texas population, aiming to uncover potential correlations and their implications in patient management.

Method: This research involved a detailed retrospective review of the UT Health RGV medical database over the past five years, focusing on patients diagnosed with diabetic neuropathy (Type 1: E10.40 to E10.49, E10.610, E10.618; Type 2: E11.40 to E11.49, E11.610, E11.618) and any associated L-series skin conditions. Efforts …

Re: Butte Priority Soils Operable Unit (Bpsou) Final Unreclaimed Sites Field Sampling Plan (Fsp) Package #10: Ur-44, Ur-45, Ur-46, Ur-47, And Ur-48, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.