Digital Commons Network^™

Analysis Of Cost-Effectiveness Of Antihypertensive Therapy In Hypertension Patients At Al-Ihsan Regional Public Hospital In 2023, Masyitah Isnaini, Widiah Widiarti, Miski Khairinisa

Pharmacology and Clinical Pharmacy Research

Hypertension is a disease that causes an abnormal increase in blood pressure, which causes cardiovascular disease. Long-term hypertension therapy requires large costs. Apart from that, existing antihypertensives are also very varied, so a cost-effectiveness analysis is needed in order to choose medications that balance costs and advantages. This study aims to determine the most economical antihypertensive medication at Al-Ihsan Regional Public Hospital in Baleendah. Based on patient medical records, this study was carried out retrospectively. Therapy data and treatment costs are the basis for the data collection process. The data is processed descriptively. The reduction in blood pressure that meets …

Bayesian Sequential Monitoring Strategies For Trials Of Digestive Cancer Therapeutics, Guillaume Mulier, Ruitao Lin, Thomas Aparicio, Lucie Biard

Faculty, Staff and Student Publications

Background: New therapeutics in oncology have presented challenges to existing paradigms and trial designs in all phases of drug development. As a motivating example, we considered an ongoing phase II trial planned to evaluate the combination of a MET inhibitor and an anti-PD-L1 immunotherapy to treat advanced oesogastric carcinoma. The objective of the paper was to exemplify the planning of an adaptive phase II trial with novel anti-cancer agents, including prolonged observation windows and joint sequential evaluation of efficacy and toxicity.

Methods: We considered various candidate designs and computed decision rules assuming correlations between efficacy and toxicity. Simulations were conducted …

Exploration Of A Potential Door Endpoint For Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia Using Six Registrational Trials For Antibacterial Drugs, Tori Kinamon, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Sarah B Doernberg, Scott R Evans, Toshimitsu Hamasaki, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Sumati Nambiar, Peter Kim, Helen W Boucher, Ramya Gopinath

Faculty, Staff and Student Publications

BACKGROUND: Desirability of outcome ranking (DOOR) is an innovative approach to clinical trial design and analysis that uses an ordinal ranking system to incorporate the overall risks and benefits of a therapeutic intervention into a single measurement. Here we derived and evaluated a disease-specific DOOR endpoint for registrational trials for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).

METHODS: Through comprehensive examination of data from nearly 4000 participants enrolled in six registrational trials for HABP/VABP submitted to the Food and Drug Administration (FDA) between 2005 and 2022, we derived and applied a HABP/VABP specific endpoint. We estimated the probability that …

Perceptions And Use Of The Athletic Training Milestones In Education: A Report From The Aate Research Network, Cailee E. Welch Bacon, Barton E. Anderson, Julie M. Cavallario, Bonnie L. Van Lunen, Lindsey E. Eberman

Clinical Practice in Athletic Training

The Athletic Training Milestones (AT Milestones) were developed as an evaluation tool to capture the breadth and depth of athletic training knowledge, skills, and behavior. However, it is unclear whether athletic training programs are implementing this tool or how they are implementing it to gauge the clinical progression of students or residents in athletic training. We aimed to explore the perceptions and use of the AT Milestones among educators in athletic training programs. We used a cross-sectional, web- based survey with open-ended questions to collect data from athletic training programs on if and how they implement the AT Milestones at …

Developing Future Managers Through Business Simulation Gaming In The Uk And Hong Kong: Exploring The Interplay Between Cognitive Realism, Decision-Making And Performance, Jonathan Lean, Robert Newbery, Jonathan Moizer, Mohamed Haddoud, Wai Mun Lim

Plymouth Business School

PurposeThis paper investigates how individuals' decision-making approach and perceptions of a game's cognitive realism affect the performance of virtual businesses in a web-based simulation game.Design/methodology/approachSurvey data are collected from 274 business simulation game users and is analysed using the fsQCA technique.FindingsThe study identifies three alternative pathways to high and low performance in a business simulation game. Results indicate that a flexible decision-making approach exists in all high performance pathway solutions. Where a game is perceived to be realistic, a more focused decision-making approach is associated with high performance. However, where perceived cognitive realism is absent, a less focused experimental decision-making …

The Last Resort: Reducing Avoidable Employee Harm By Improving The Application Of The Disciplinary Policy And Process, Andrew Cooper, Kevin Rui-Han Teoh, Ruth Madine, Adrian Neal, Aled Jones, Ammarah Hussain, Doris A. Behrens

School of Nursing and Midwifery

Introduction: There is growing evidence within the healthcare sector that employee investigations can harm individuals involved in the process, an organization’s culture and the delivery of its services.MethodsThis paper details an intervention developed by an NHS Wales organization to reduce the number of its employee investigations through an organization-wide focus that promoted a ‘last resort’ approach and introduced the concept of ‘avoidable employee harm’. A range of associated improvement initiatives were developed to support behavior change among those responsible for determining whether an employee investigation should be initiated.Results: Over a 13-month period, organizational records showed an annual reduction of 71% …

The Value Of Using Validated Competency-Based Assessments Across The Career Span Of An Athletic Trainer, Matthew Drescher, Lindsey Eberman

Clinical Practice in Athletic Training

No abstract provided.

The Development, Implementation, And Value Of The Athletic Training Milestones For Assessing Progressive Clinical Behaviors, Hollie Walusz, Eric Sauers, Mark Laursen, Forrest Pecha

Clinical Practice in Athletic Training

No abstract provided.

Standardized Patient Evaluation Tool: A Valid Measure Of The Core Competencies, Lindsey E. Eberman, Jessica Edler Nye

Clinical Practice in Athletic Training

No abstract provided.

L-Pbf High-Throughput Data Pipeline Approach For Multi-Modal Integration, Kristen J. Hernandez, Thomas G. Ciardi, Rachel Yamamoto, Mingjian Lu, Arafath Nihar, Jayvic Cristian Jimenez, Pawan K. Tripathi, John J. Lewandowski, Roger H. French, Laura S. Bruckman

Faculty Scholarship

Metal-based additive manufacturing requires active monitoring solutions for assessing part quality. Multiple sensors and data streams, however, generate large heterogeneous data sets that are impractical for manual assessment and characterization. In this work, an automated pipeline is developed that enables feature extraction from high-speed camera video and multi-modal data analysis. The framework removes the need for manual assessment through the utilization of deep learning techniques and training models in a weakly supervised paradigm. We demonstrate this pipeline’s capability over 700,000 high-speed camera frames. The pipeline successfully extracts melt pool and spatter geometries and links them to corresponding pyrometry, radiography, and …

Laser-Induced Electrochemical Biosensor Modified With Graphene-Based Ink For Label-Free Detection Of Alpha-Fetoprotein And 17Β-Estradiol, Ridma Tabassum, Pritu P. Sarkar, Ahmed Hasnain Jalal, Ali Ashraf, Nazmul Islam

Mechanical Engineering Faculty Publications

In this research, a novel electrochemical biosensor is proposed based on inducing graphene formation on polyimide substrate via laser engraving. Graphene polyaniline (G-PANI) conductive ink was synthesized by planetary mixing and applied to the working zone of the developed sensor to effectively enhance the electrical signals. The laser-induced graphene (LIG) sensor was used to detect alpha-fetoprotein (AFP) and 17β-Estradiol (E2) in the phosphate buffer saline (PBS) buffer and human serum. The electrochemical performance of the biosensor in determining these biomarkers was investigated by differential pulse voltammetry (DPV) and chronoamperometry (CA). In a buffer environment, alpha-fetoprotein (AFP) and 17β-Estradiol detection range …

Instrumental Variable And Colocalization Analyses Identify Endotrophin And Htra1 As Potential Therapeutic Targets For Coronary Artery Disease, Paul C Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H Burks, Junedh Amrute, Jared S Elenbaas, Chul Joo Kang, Erica P Young, Philipp E Scherer, Nathan O Stitziel

2020-Current year OA Pubs

Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic targets for human disease by nominating causal genes in genome-wide association study (GWAS) loci. We conducted cis-IV analyses for 20,125 genes and 1,746 plasma proteins with CAD using molecular trait quantitative trait loci variant (QTLs) data from three different studies. 19 proteins and 119 genes were significantly associated with CAD risk by IV analyses and demonstrated evidence of genetic colocalization. Notably, our analyses validated well-established targets …

Assessing Breast Disease With Deep Learning Model Using Bimodal Bi-View Ultrasound Images And Clinical Information, Fengping Liang, Yihua Song, Xiaoping Huang, Tong Ren, Qiao Ji, Yanan Guo, Xiang Li, Yajuan Sui, Xiaohui Xie, Lanqing Han, Yuanqing Li, Yong Ren, Zuofeng Xu

Faculty, Staff and Students Publications

Breast cancer is the second leading cause of carcinoma-linked death in women. We developed a multi-modal deep-learning model (BreNet) to differentiate breast cancer from benign lesions. BreNet was constructed and trained on 10,108 images from one center and tested on 3,762 images from two centers in three steps. The diagnostic ability of BreNet was first compared with that of six radiologists; a BreNet-aided scheme was constructed to improve the diagnostic ability of the radiologists; and the diagnosis of real-world radiologists' scheme was then compared with the BreNet-aided scheme. The diagnostic performance of BreNet was superior to that of the radiologists …

Teacher Knowledge And Confidence Integrating Social Change Concepts In K–12 Classrooms, Amy White, Fran Reed, Tina Marshall-Bradley, Kathy Strang

Journal of Sustainable Social Impact

The purpose of this survey research was to examine the perspectives of K–12 classroom teachers about their knowledge of social change concepts and their confidence in implementing these into their existing curriculum. A questionnaire was used to (a) examine the perspectives of K–12 classroom teachers about the knowledge, skills, and resources they need to implement social change concepts into their teaching and (b) define areas of social change that teachers struggle to implement in K–12 classrooms. We employed Wilcoxen signed rank tests to determine if differences existed between what teachers reported they knew and their confidence in integrating 11 social …

Exploration Of Therapists' Use Of Bibliotherapy As A Clinical Strategy For Military Children, Destiny Huff

Walden Dissertations and Doctoral Studies

Military-connected children face unique life stressors related to their parents serving in the military. Therapists play an integral role in supporting these families. Specifically, research on therapists’ use of bibliotherapy as a clinical strategy to support these children’s needs is recommended. Bibliotherapy uses written material such as books, stories, and poems to address clients’ needs. The purpose of this interpretive descriptive qualitative study was to explore therapists’ use of bibliotherapy as a clinical strategy to address the unique stressors faced by military children ages 3-8 years old. Shrodes’s model of bibliotherapy was used as the theoretical framework. Data were collected …

Artificial Chordae Implantation Vs Posterior Leaflet Preservation: A Comparison Of Midterm Results After Mitral Valve Replacement, Salih Salihi, Bilhan Özalp, Fatih Toptan, Ibrahim Kara

The Texas Heart Institute Journal

BACKGROUND: Various techniques have been proposed for the preservation of the subvalvular apparatus (SVA) in mitral valve replacement. This study aimed to compare the midterm results of posterior leaflet preservation with the results of selective preservation of the SVA involving artificial chordae implantation in terms of left ventricular performance in patients undergoing mitral valve replacement.

METHODS: In total, 127 patients were included in this study. Patients were allocated to 1 of 2 groups according to the techniques used to preserve the SVA. Patients in group 1 underwent posterior leaflet preservation: The anterior leaflet was completely resected, and the posterior leaflet …

Minimally Invasive Mitral Valve Surgery Using A Cold Fibrillatory Cardiac Arrest Technique In Patients With Prior Cardiac Surgery, Ahmed Ali, Zachary Gray, Gabriel Loor, Alexis E Shafii, Todd K Rosengart, Kenneth K Liao

The Texas Heart Institute Journal

OBJECTIVE: Minimally invasive mitral valve surgery (mini-MVS) is typically reserved for patients who have not undergone open cardiac surgery. In the reoperative setting, using intrapericardial dissection for crossclamping the aorta through a minimally invasive approach can be difficult and, at times, risky. Cold fibrillatory cardiac arrest (CFCA) with systemic cardiopulmonary bypass without cross-clamping is a well-described technique; however, data about its safety for patients who undergo reoperative mini-MVS are limited.

METHODS: Data for 34 patients who underwent reoperative mini-MVS with CFCA from March 2017 to March 2022 were reviewed retrospectively. A mini right thoracotomy (n = 30) or robotic (n …

Whole Cervix Imaging Of Collagen, Muscle, And Cellularity In Term And Preterm Pregnancy, Wenjie Wu, Zhexian Sun, Hansong Gao, Yuan Nan, Stephanie Pizzella, Haonan Xu, Josephine Lau, Yiqi Lin, Hui Wang, Pamela K Woodard, Hannah R Krigman, Qing Wang, Yong Wang

2020-Current year OA Pubs

Cervical softening and dilation are critical for the successful term delivery of a fetus, with premature changes associated with preterm birth. Traditional clinical measures like transvaginal ultrasound and Bishop scores fall short in predicting preterm births and elucidating the cervix's complex microstructural changes. Here, we introduce a magnetic resonance diffusion basis spectrum imaging (DBSI) technique for non-invasive, comprehensive imaging of cervical cellularity, collagen, and muscle fibers. This method is validated through ex vivo DBSI and histological analyses of specimens from total hysterectomies. Subsequently, retrospective in vivo DBSI analysis at 32 weeks of gestation in ten term deliveries and seven preterm …

Trackins (Trk-Targeting Drugs): A Novel Therapy For Different Diseases, George N Chaldakov, Luigi Aloe, Stanislav G Yanev, Marco Fiore, Anton B Tonchev, Manlio Vinciguerra, Nikolai T Evtimov, Peter Ghenev, Krikor Dikranian

2020-Current year OA Pubs

Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases. The following pressing question thus remains: what are the pathogenic routes and how can be they counteracted for therapeutic purposes? Human cells contain >500 protein kinases and nearly 200 protein phosphatases, acting on thousands of proteins, including cell growth factors. We herein discuss neurotrophins with pathogenic or metabotrophic abilities, particularly brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), pro-NGF, neurotrophin-3 (NT-3), and their receptor Trk (tyrosine receptor …

Targeted Co-Expression Networks For The Study Of Traits, A Gómez-Pascual, G Rocamora-Pérez, L Ibanez, J A Botía

2020-Current year OA Pubs

Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used approach for the generation of gene co-expression networks. However, networks generated with this tool usually create large modules with a large set of functional annotations hard to decipher. We have developed TGCN, a new method to create Targeted Gene Co-expression Networks. This method identifies the transcripts that best predict the trait of interest based on gene expression using a refinement of the LASSO regression. Then, it builds the co-expression modules around those transcripts. Algorithm properties were characterized using the expression of 13 brain regions from the Genotype-Tissue Expression project. When …

Quality Assessment Of Life Cycle Inventory Data For Fibre-Reinforced Polymer Composite Materials, Badr Moutik, John Summerscales, Jasper Graham-Jones, Richard Pemberton

School of Engineering, Computing and Mathematics

Composite industry growth, driven by the demand for lightweight and high-performance structures, has intensified challenges and inquiries regarding its lifecycle environmental impact, catalysing an increase in Life Cycle Assessment (LCA) studies. These studies have revealed significant concerns about the quality and reliability of Life Cycle Inventory (LCI) data, highlighting the risk of inaccuracies that could undermine LCA outcomes and produce misleading conclusions. This situation underscores the critical need for stringent data quality assurance. This study aims to critically assess LCI data quality for composite materials to enhance reliability and utility of LCA in promoting sustainable industry development. Objectives include reviewing …

Novel Mutation Leading To Splice Donor Loss In A Conserved Site Of Dmd Gene Causes Duchenne Muscular Dystrophy With Cryptorchidism, Jianhai Chen, Yangying Jia, Jie Zhong, Kun Zhang, Hongzheng Dai, Guanglin He, Fuping Li, Li Zeng, Chuanzhu Fan, Huayan Xu

Faculty, Staff and Students Publications

Background: As one of the most common congenital abnormalities in male births, cryptorchidism has been found to have a polygenic aetiology according to previous studies of common variants. However, little is known about genetic predisposition of rare variants for cryptorchidism, since rare variants have larger effective size on diseases than common variants.

Methods: In this study, a cohort of 115 Chinese probands with cryptorchidism was analysed using whole-genome sequencing, alongside 19 parental controls and 2136 unaffected men. Additionally, CRISPR-Cas9 editing of a conserved variant was performed in a mouse model, with MRI screening used to observe the phenotype.

Results: In …

The Relationship Between Mental Health, Self And Other Stigma, And Help-Seeking Behaviors In Ethnic Minority Undergraduate Students, Briane Souki

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Racial and ethnic minority undergraduate students are disproportionately affected by mental health challenges and are less likely to seek support due to self-stigma and stigma from others, cultural perceptions of mental health, and help-seeking behaviors (Tucker et al., 2013). It is critical to understand mental health in cultural contexts because they influence help seeking behaviors for ethnic minority college students. These stigmas are thoughts that influence the help-seeking behaviors of students. Many ethnic minority students have internalized self-stigma toward help seeking. Part of overcoming minority student hesitancy toward help-seeking is to promote culturally aware mental health practices. In predominantly white …

Divine Retribution, Anna Payne

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Sexual abuse has always been an issue in all cultures throughout the world and history. Easton et al. delved into the problems of barriers to disclosing child sexual abuse with 460 male participants which showed that 61.7% of them reported CSA at the hands of a priest. As that study was conducted, Helsel and McCormack tackled the effects of CSA on the nervous system and psyche. While religion is used as a coping mechanism, it is also a tool for maltreatment from clergy sexually abusing children to parents seeking ways to rid the child of demons. There have been over …

Effects Of Emotional Intelligence And Social Support On The Relationship Between Childhood Maltreatment And Disordered Eating, Rachel E. Kilby

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Current research has established a connection between childhood maltreatment and eating disorders, and some studies have looked at emotional intelligence or social support as mediators of this connection. However, little research has looked at how emotional intelligence and social support work together in the relationship between childhood maltreatment and eating disorders. This study looked at how emotional intelligence and social support act as mediators in this relationship. Undergraduate students (N=134) were administered the Childhood Trauma Questionnaire (CTQ-90), Wong-Law Emotional Intelligence Scale (WLEIS), Difficulties in Emotion Regulation Scale (DERS), Perceived Social Support Scale (PSSS), and the Eating Attitudes Test (EAT-26). Correlations …

Students’ Knowledge And Attitude Towards Plagiarism: A Case Of Lusaka Apex Medical University Students, Dalitso Mvula, Treasure Chisakula

Library Philosophy and Practice (e-journal)

Laws guide societies in the world. These laws are meant to create an environment that ensures citizens’ rights are respected. The same happens in academia. There are guidelines that students follow in the execution of their assignments, examinations and research in higher institutions. These guidelines are meant to ensure that there is no any form of academic dishonesty being perpetuated by the students. This paper investigated Lusaka Apex Medical University students’ knowledge and attitude towards plagiarism. The study sought to assess the knowledge of LAMU students towards plagiarism, examine the attitude of LAMU students towards plagiarism, assess factors that foster …

An Investigation Into The Consumption Of Caffeinated Energy Drinks Among University Students In Ireland, Jessica Holmes, Denas Molotokas, Ralfas Molotokas

International Undergraduate Journal of Health Sciences

Objectives: To investigate the consumption patterns of caffeinated energy drinks among university students in the south of Ireland

Materials and Methods: An online survey was created using Google Forms to investigate the consumption of caffeinated energy drinks among university students in Ireland. It was distributed to students via social media and email from the 8th of March to the 21st of March 2023 inclusive. A total of 281 responses were analysed and validated by data cleaning on Microsoft Excel, with 10 incomplete responses discarded, yielding 271 validated responses for statistical analysis.

Results: The majority of survey respondents (71.3%) reported consuming …

A Review Of The Role Of Single-Cell Rna-Sequencing (Scrna-Seq) In The Transcriptome Analysis Of Ductal Carcinoma In Situ (Dcis), Ali Maeve Fitzgerald, Francesca Tiso, Eldar T. Abdullaev, Kirsten Kübler

International Undergraduate Journal of Health Sciences

Ductal carcinoma in situ (DCIS) remains one of the most reported lesions detected by mammography screening programmes, yet our understanding of its progression to malignancy and markers of invasiveness is limited. Although a non-obligate precursor of invasive ductal carcinoma (IDC), all currently diagnosed DCIS patients are indiscriminately subjected to mastectomy or breast-conserving therapy (BCT) and radiotherapy. With less than 50% of untreated DCIS progressing to IDC, questions have been raised surrounding the over-treatment of indolent DCIS.

Thus, one of the central clinical challenges is to assess the risk of disease progression, which has prompted research efforts aimed at refining prognostic …

An Investigation Into Aetiology, Detection And Treatment Of Neonatal Alloimmune Thrombocytopenia, Mairead Horan

International Undergraduate Journal of Health Sciences

NAIT is a rare disorder with a similar aetiology to HDN, however unlike its erythrocyte counterpart, thrombocyte immunisation can occur within the first pregnancy. (Giouleka et al., 2023). The most common antibodies implicated are HLA-1a. (Winkelhorst et al., 2017). 2.5% of the Caucasian population are HPA-1a negative, of this population 33% are HLA-DR-B3*0101 positive increasing the risk of producing an alloantibody upon encountering the HPA-1a antigen. The maternal system becomes alloimmunised to the foreign paternal antigens of the foetus/neonate, which cross the placenta causing low platelets of the foetus. (Giouleka et al., 2023).

A third of antigen-positive neonates born to …

Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 4, Issue 1, July 2024, Iujhs Full Issue

International Undergraduate Journal of Health Sciences

Full Issue: The International Undergraduate Journal of Health Sciences, Volume 4, Issue 1, July 2024