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Jeremy Store Petitioner/ Appellant V. Utah Labor Commission And Nakeishia Poulton, Respondents/Appellees : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Utah Labor Commission, Case No. 8-07-0448

Tyler James Larsen, Counsel for Appellant

Brian Jackson, Christopher Hill, Counsel for Appellee

June 2024 Berkeley Pit Migratory Waterfowl Protection Monthly Report, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Toxicity Of Waterpipe Tobacco Smoking: The Role Of Flavors, Sweeteners, Humectants, And Charcoal, Nada O F Kassem, Robert M. Strongin, Andrea M. Stroup, Marielle C. Brinkman, Ahmad El-Hellani, Hanno C. Erythropel, Arash Etemadi, Maciej L. Goniewicz, Eleanore G. Hansen, Noura O. Kassem, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

Waterpipe tobacco (WPT) smoking is a public health concern, particularly among youth and young adults. The global spread of WPT use has surged since the introduction of pre-packaged flavored and sweetened WPT, which is widely marketed as a safer tobacco alternative. Besides flavorants and sugars, WPT additives include humectants, which enhance the moisture and sweetness of WPT, act as solvents for flavors, and impart smoothness to the smoke, thus increasing appeal to users. In the United States (U.S.), unlike cigarette tobacco flavoring (with the exception of menthol), there is no FDA product standard or policy in place prohibiting sales of …

Red Harvester Ant, Pogonomyrmex Barbatus, Nests Impact Soil Compaction But Not Temperature In Peri-Urban Habitats Of The Lower Rio Grande Valley, Geovanni Hernandez, Hannah J. Penn, Richard Cano, Lilly Victoria Elliott-Vidaurri, Robin A. Choudhury

School of Earth, Environmental, & Marine Sciences Faculty Publications

Ants are vital ecosystem engineers that can influence soil properties, subsequent soil processes, and associated biota via underground nest construction. Harvester ants consume seeds and are often found in arid areas. They frequently alter the soil chemistry and bulk density of the soils in and around their nest sites. Many species of harvester ants also intentionally remove vegetation around their nest openings, which creates cones or discs of bare soil that may further alter soil temperatures. However, much of the work to study the impacts of harvester ants on soil properties has occurred in shrubland and grassland settings rather than …

A Guide To Transcatheter Aortic Valve Design And Systematic Planning For A Redo-Tav (Tav-In-Tav) Procedure, Vinayak N Bapat, Miho Fukui, Syed Zaid, Atsushi Okada, Hasan Jilaihawi, Toby Rogers, Omar Khalique, João L Cavalcante, Uri Landes, Janarthanan Sathananthan, Giuseppe Tarantini, Gilbert H L Tang, Daniel J Blackman, Ole De Backer, Michael J Mack, Martin B Leon

Faculty, Staff and Students Publications

Transcatheter aortic valve replacement (TAVR) has become more common than surgical aortic valve replacement since 2016, with over 200,000 procedures globally each year. As patients increasingly outlive their TAVR devices, managing these cases is a growing concern. Treatment options include surgical removal of the old TAVR device (transcatheter aortic valve [TAV] explant) or implantation of a new transcatheter aortic valve (redo TAV). Redo TAV is complex because of the unique designs of TAV devices; compatibility issues; and the need for individualized planning based on factors such as implant depth, shape, and coronary artery relationships. This review serves as a comprehensive …

Onecut2 Acts As A Lineage Plasticity Driver In Adenocarcinoma As Well As Neuroendocrine Variants Of Prostate Cancer, Chen Qian, Qian Yang, Mirja Rotinen, Rongrong Huang, Hyoyoung Kim, Brad Gallent, Yiwu Yan, Radu M Cadaneanu, Baohui Zhang, Salma Kaochar, Stephen J Freedland, Edwin M Posadas, Leigh Ellis, Dolores Di Vizio, Colm Morrissey, Peter S Nelson, Lauren Brady, Ramachandran Murali, Moray J Campbell, Wei Yang, Beatrice S Knudsen, Elahe A Mostaghel, Huihui Ye, Isla P Garraway, Sungyong You, Michael R Freeman

Faculty, Staff and Students Publications

Androgen receptor- (AR-) indifference is a mechanism of resistance to hormonal therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates resistance through multiple drivers associated with adenocarcinoma, stem-like and neuroendocrine (NE) variants. Direct OC2 gene targets include the glucocorticoid receptor (GR; NR3C1) and the NE splicing factor SRRM4, which are key drivers of lineage plasticity. Thus, OC2, despite its previously described NEPC driver function, can indirectly activate a portion of the AR cistrome through epigenetic activation of GR. Mechanisms by which OC2 regulates gene expression include promoter binding, enhancement of genome-wide chromatin accessibility, and super-enhancer reprogramming. Pharmacologic …

A Trivalent Protein-Based Pan-Betacoronavirus Vaccine Elicits Cross-Neutralizing Antibodies Against A Panel Of Coronavirus Pseudoviruses, Syamala Rani Thimmiraju, Rakesh Adhikari, Jeanna R Redd, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Yi-Lin Chen, Suman Sharma, Amandeep Kaur, Nestor L Uzcategui, Shannon E Ronca, Wen-Hsiang Chen, Jason T Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Jeroen Pollet

Faculty, Staff and Students Publications

The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.

Cefepime-Induced Encephalopathy In Patients Treated For Urinary Tract Infection, Novera Inam, Nuzhat Nisa, Christopher Stewart, Mitchell Fisher, Suporn Sukpraprut-Braaten

Student Publications

Cefepime is a fourth-generation cephalosporin antibiotic administered intravenously used to treat various bacterial infections, including urinary tract infections. Administering cefepime to patients should be done with caution, understanding both potential risks and side effects. A 74-year-old female presented to the family medicine clinic with abdominal pain and a history of urinary tract infections. The workup included a CT scan that showed bowel obstruction and bladder wall thickening. Due to a history of urinary tract infections, three days following the presentation, the patient underwent an explorative laparotomy. Following the laparotomy, the patient was started on cefepime, a fourth-generation cephalosporin antibiotic. Five …

Association Between Diabetes Mellitus And Total Hip Arthroplasty Outcomes: An Observational Study Using The Us National Inpatient Sample, Sumanth Chandrupatla, Kranti Rumalla, Jasvinder A Singh

Faculty, Staff and Students Publications

OBJECTIVES: To investigate the association of diabetes with postoperative outcomes in patients undergoing primary total hip arthroplasty (THA).

DESIGN: Retrospective cohort study using data from the US National Inpatient Sample (NIS).

SETTING: Study cohort was hospitalisations for primary THA in the USA, identified from the 2016-2020 NIS.

PARTICIPANTS: We identified 2 467 215 adults in the 2016-2020 NIS who underwent primary THA using International Classification of Diseases, 10th Revision codes. Primary THA hospitlizations were analysed as the overall group and also stratified by the underlying primary diagnosis for THA.

OUTCOME MEASURES: Outcome measures of interest were the length of hospital …

Targeted Degradation Of Extracellular Mitochondrial Aspartyl-Trna Synthetase Modulates Immune Responses, Benjamin S Johnson, Janet S Lee, Et Al.

2020-Current year OA Pubs

The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. We describe a mitochondrial protein, aspartyl-tRNA synthetase (DARS2), which is released in circulation during bacterial pneumonia in humans and displays intrinsic innate immune properties and cellular repair properties. DARS2 interacts with a bacterial-induced ubiquitin E3 ligase subunit, FBXO24, which targets the synthetase for ubiquitylation and degradation, a process that is inhibited by DARS2 acetylation. During experimental pneumonia, Fbxo24 knockout mice exhibit elevated DARS2 levels with an increase in pulmonary cellular and cytokine levels. In silico modeling identified an FBXO24 inhibitory compound with immunostimulatory …

Reconciling Shared Versus Context-Specific Information In A Neural Network Model Of Latent Causes, Qihong Lu, Tan T Nguyen, Qiong Zhang, Uri Hasson, Thomas L Griffiths, Jeffrey M Zacks, Samuel J Gershman, Kenneth A Norman

2020-Current year OA Pubs

It has been proposed that, when processing a stream of events, humans divide their experiences in terms of inferred latent causes (LCs) to support context-dependent learning. However, when shared structure is present across contexts, it is still unclear how the "splitting" of LCs and learning of shared structure can be simultaneously achieved. Here, we present the Latent Cause Network (LCNet), a neural network model of LC inference. Through learning, it naturally stores structure that is shared across tasks in the network weights. Additionally, it represents context-specific structure using a context module, controlled by a Bayesian nonparametric inference algorithm, which assigns …

Senescent Cancer-Associated Fibroblasts In Pancreatic Adenocarcinoma Restrict Cd8+ T Cell Activation And Limit Responsiveness To Immunotherapy In Mice, Benjamin Assouline, Sheila A Stewart, Et Al.

2020-Current year OA Pubs

Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions. However, the identities and traits of these cells, and the potential for improving cancer therapy through their targeting, remain poorly characterized. Here, we identify a senescent subset within previously-defined cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinomas (PDAC) and in premalignant lesions in mice and humans. Senescent CAFs isolated from mouse and humans expressed elevated levels of immune-regulatory genes. Depletion of senescent CAFs, either genetically or using the Bcl-2 inhibitor ABT-199 (venetoclax), increased the proportion of activated CD8

Recruiting And Engaging Heterosexual-Identified Men Who Have Sex With Men: A Brief Report Of Considerations For Sex Researchers, Travis R. Scheadler, Salem Rao, Paul Shuper, Oliver Beer, Tyrone Curtis, Lauren B. Mcinroy, Andrew D. Eaton

School of Health Professions

Heterosexual-identified men who have sex with men (H-MSM) are a unique population difficult to identify and recruit for research and practice. Yet, engaging H-MSM remains a top research priority to learn more about this population’s health needs. A scoping review was conducted to develop a stronger understanding of recruitment patterns involving H-MSM in research. The search and screening procedures yielded 160 total articles included in the present study. Most studies relied on venue-based and internet-based recruitment strategies. Thematic analysis was then used to identify three themes. Locations of H-MSM’s sexual encounters related to where sex researchers may recruit participants; sociocultural …

Effects Of Protein Restriction On Insulin-Like Growth Factor (Igf)-1 In Men With Prostate Cancer: Results From A Randomized Clinical Trial, Maria L Cagigas, Giovanni Fiorito, Beatrice Bertozzi, Andrius Masedunskas, Edda Cava, Francesco Spelta, Nicola Veronese, Valeria Tosti, Gayathiri Rajakumar, Tiana Pelaia, Arnold D Bullock, Robert S Figenshau, Gerald L Andriole, Luigi Fontana

2020-Current year OA Pubs

BACKGROUND: Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However, it is unclear whether an isocaloric protein-restricted diet affects IGF-1 and IGFBPs in men with prostate cancer.

METHODS: In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded end-point trial, 38 consenting overweight (BMI 30.5 ± 5.5 kg/m

RESULTS: Contrary to our hypothesis, feeding individuals an isocaloric protein-restricted diet did not result in a significant reduction in serum IGF-1. Moreover, there was no observed increase in serum IGFBP-1 or IGFBP-3 concentration.

CONCLUSION: …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 120 – Bonanza Dump., Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Special Education Preschool Teachers’ Perspectives, Attitudes, And Self-Efficacy Towards Inclusive Education, Mieke Kramer Tavares

Dissertations

Purpose: The purpose of this study was to investigate the perspectives of special education preschool teachers in California regarding the inclusion of children with disabilities in general education preschool classrooms. Furthermore, the study examined the self-evaluation of these teachers regarding their abilities to support children with disabilities in general education classrooms. Last, the study aimed to identify additional factors that impact the attitudes of teachers towards including children with disabilities in general education preschool classrooms.

Methodology: A mixed methods nonexperimental descriptive, sequential, convergent research design was employed. Data collection tools included surveys (quantitative) and interviews (qualitative). In Phase 1, dependent …

Smokejumper Obituary: Yellowtail, Rudolph Kenneth “Rudy” (Missoula 1987), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

A Rapid Review Of The Barriers And Facilitators Of Mental Health Service Access Among Veterans And Their Families, Natalie Ein, Julia Gervasio, Kate St. Cyr, Jenny J.W. Liu, Clara Baker, Anthony Nazarov, J. Don Richardson

MacDonald Franklin OSI Research Centre

Introduction: Transitioning to civilian life after military service can be challenging for both Veterans and their families. Accessible mental health services are crucial during this period to provide support. The objective of this review was to conduct a rapid review to capture the barriers and identify facilitators that influence access to mental health services for Veterans and their families during the post-service transition period.

Methods: This review was conducted using the Cochrane Handbook for Systematic Reviews of Interventions as a methodological framework and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - Rapid Review (PRISMA-RR).

Results: A total …

Connecting With Your Teen, Maggie Mckay, Brian Burghardt

Parent-ish Podcast

As your child grows up, it can become harder to find ways to connect with them. Dr. Brian Burghardt discusses how you can connect with your teen in a genuine way while respecting their boundaries in our newest podcast.

Click here to stream the podcast episode.

Can The Necrophagous Blow Fly Calliphora Vicina (Diptera: Calliphoridae) Be Reared On Plant-Based Meal?, David F. Cook, Muhammad Shoaib Tufail, Sasha C. Voss

Horticulture Research Articles

The use of the blow fly Calliphora vicina as a potential pollination species to augment the current reliance on honeybees (Apis mellifera) in Australian horticulture requires knowledge of how best to mass-rear this fly species. Calliphora vicina lays eggs onto carrion soon after death, and the resultant larvae that hatch are necrophagous and feed on the decomposing tissues of the dead animal. Newly hatched larvae of this fly were provided with plant-based meals (soya bean and canola) and compared with larvae provided with livestock-derived meatmeal to determine if plant-based meal could be used to mass-rear this blow fly species. Both …

Quality Improvement Project: Incivility In Nursing Education: Utilizing An Educational Module And Professionalism Guide To Address Incivility In A Nursing Students, Jennifer Schadler

Doctor of Nursing Practice Projects

Incivility is a well-documented issue in the nursing profession that begins in nursing education and follows graduates into nursing practice. Nursing academia has a responsibility to address incivility to prevent inappropriate behaviors from becoming embedded into the culture. The problem addressed in this quality improvement project is incivility among nursing students at a private college. The purpose of this project was to apply evidence-based incivility interventions to address uncivil behaviors of nursing students. The hypothesis was that the implementation of a civility mentor module and professionalism guide would impact perceived incivility among nursing students. The project was conducted using the …

Refining The Optimal Caf Cluster Marker For Predicting Tme-Dependent Survival Expectancy And Treatment Benefits In Nsclc Patients, Kai Li, Rui Wang, Guo-Wei Liu, Zi-Yang Peng, Ji-Chang Wang, Guo-Dong Xiao, Shou-Ching Tang, Ning Du, Jia Zhang, Jing Zhang, Hong Ren, Xin Sun, Yi-Ping Yang, Da-Peng Liu

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The tumor microenvironment (TME) plays a pivotal role in the onset, progression, and treatment response of cancer. Among the various components of the TME, cancer-associated fibroblasts (CAFs) are key regulators of both immune and non-immune cellular functions. Leveraging single-cell RNA sequencing (scRNA) data, we have uncovered previously hidden and promising roles within this specific CAF subgroup, paving the way for its clinical application. However, several critical questions persist, primarily stemming from the heterogeneous nature of CAFs and the use of different fibroblast markers in various sample analyses, causing confusion and hindrance in their clinical implementation. In this groundbreaking study, we …

Water Throughout The Green Energy Transition: Hydrosocial Dimensions Of Coal, Natural Gas, And Lithium, Joshua J. Cousins, Alida Cantor, Bethani Turley

Geography Faculty Publications and Presentations

Energy transitions are reshaping hydrosocial relations. How they will be reshaped, however, depends on location and water's material relationship to other resources and industrial activities embedded within energy transitions. To highlight this, we focus on three different resources—coal, natural gas, and lithium—to signal how the water–energy nexus will be reworked in a transition away from fossil fuels. We examine the water–coal nexus as an example of a resource relationship that is transitioning out, or that is being moved away from in the green energy transition. Natural gas represents the “bridge fuel” used through the transition. Lithium illustrates a resource inside …

Refining The Optimal Caf Cluster Marker For Predicting Tme-Dependent Survival Expectancy And Treatment Benefits In Nsclc Patients, Kai Li, Rui Wang, Guo Wei Liu, Zi Yang Peng, Ji Chang Wang, Guo Dong Xiao, Shou Ching Tang, Ning Du, Jia Zhang, Jing Zhang, Hong Ren, Xin Sun, Yi Ping Yang, Da Peng Liu

School of Medicine Faculty Publications

The tumor microenvironment (TME) plays a pivotal role in the onset, progression, and treatment response of cancer. Among the various components of the TME, cancer-associated fibroblasts (CAFs) are key regulators of both immune and non-immune cellular functions. Leveraging single-cell RNA sequencing (scRNA) data, we have uncovered previously hidden and promising roles within this specific CAF subgroup, paving the way for its clinical application. However, several critical questions persist, primarily stemming from the heterogeneous nature of CAFs and the use of different fibroblast markers in various sample analyses, causing confusion and hindrance in their clinical implementation. In this groundbreaking study, we …

Reducing Rates Of Blood Culture Contamination In The Emergency Room, Erika Goldberg

Student Scholarly Projects

Practice Problem: In one emergency room (ER) blood cultures (BC) drawn by nurses had a high contamination rate due to lack of collection standards, which lead to poor patient outcomes.

PICOT: The PICOT question that guided this project was; In adult emergency room patients where blood cultures are drawn (P), how does implementation of an evidence-based practice method (I), compared to the standard method of obtaining blood cultures (C), affect blood culture contamination rates (O), within ten weeks. (T)?

Evidence: Based on multiple sources within the literature; best evidence for lowering blood culture contamination rates (BCC) is done using EBP …

Radium-223 Treatment Produces Prolonged Suppression Of Resident Osteoblasts And Decreased Bone Mineral Density In Trabecular Bone In Osteoblast Reporter Mice, Song-Chang Lin, Guoyu Yu, Paul G Corn, Jossana Damasco, Yu-Chen Lee, Jian H Song, Nora M Navone, Christopher J Logothetis, Marites P Melancon, Theocharis Panaretakis, Sue-Hwa Lin

Faculty, Staff and Student Publications

Radium 223 (Ra-223) is an α-emitting bone-homing radiopharmaceutical that targets tumor-induced osteoblasts and is used to reduce bone pain and prolong overall survival in men with bone-metastatic, castrate-resistant prostate cancer. However, increased fracture risk in skeletal sites with no bone metastasis has been observed in patients treated with Ra-223. Both luciferase- or green fluorescence protein (GFP)-labeled osteoblast reporter mice were used to monitor the effect of Ra-223 on resident osteoblasts and normal bone structure. Upon Ra-223 treatment, 70% of resident osteoblasts were reduced within 2 days, and the osteoblast reduction lasted for at least 18 weeks without detectable recovery, as …

Transcatheter Heart Valve Explant With Infective Endocarditis-Associated Prosthesis Failure And Outcomes: The Explant-Tavr International Registry, Mateo Marin-Cuartas, Gilbert H L Tang, Philipp Kiefer, Shinichi Fukuhara, Rudiger Lange, Katherine B Harrington, Shekhar Saha, Christian Hagl, Neal S Kleiman, Sachin S Goel, Joerg Kempfert, Paul Werner, George A Petrossian, Arnar Geirsson, Nimesh D Desai, Michael W A Chu, Oliver D Bhadra, Christian Shults, Andrea Garatti, Flavien Vincent, Kendra J Grubb, Joshua B Goldberg, Michael J Mack, Thomas Modine, Paolo Denti, Tsuyoshi Kaneko, Vinayak N Bapat, Michael J Reardon, Michael A Borger, Syed Zaid

Faculty, Staff and Students Publications

Background and aims: Surgical explantation of transcatheter heart valves (THVs) is rapidly increasing, but there are limited data on patients with THV-associated infective endocarditis (IE). This study aims to assess the outcomes of patients undergoing THV explant for IE.

Methods: All patients who underwent THV explant between 2011 and 2022 from 44 sites in the EXPLANT-TAVR registry were identified. Patients with IE as the reason for THV explant were compared to those with other mechanisms of bioprosthetic valve dysfunction (BVD).

Results: A total of 372 patients from the EXPLANT-TAVR registry were included. Among them, 184 (49.5%) patients underwent THV explant …

Implantable And Semi-Implantable Biosensors For Minimally Invasive Disease Diagnosis, Yameng Xu, Jingyuan Zhang, Wilson Z. Ray, Matthew R. Macewan

2020-Current year OA Pubs

No abstract provided.

Comparison Of The Symptom Networks Of Long-Covid And Chronic Fatigue Syndrome: From Modularity To Connectionism, Michael Hyland, Yuri Antonacci, Alison Bacon

School of Psychology

The objective was to compare the symptom networks of long-COVID and chronic fatigue syndrome (CFS) in conjunction with other theoretically relevant diagnoses in order to provide insight into the etiology of medically unexplained symptoms (MUS). This was a cross-sectional comparison of questionnaire items between six groups identified by clinical diagnosis. All participants completed a 65-item psychological and somatic symptom questionnaire (GSQ065). Diagnostically labelled groups were long-COVID (N = 107), CFS (N = 254), irritable bowel syndrome (IBS, N = 369), fibromyalgia (N = 1,127), severe asthma (N = 100) and healthy group (N = 207). The 22 symptoms that best …

Identifying Driving Factors Of Inundation Susceptibility In Thailand With The Frequency Ratio Method, Zachary Zoet, Jim Wilson

The Geographical Bulletin

Inundation models tend to cover geographically small areas at large-scales. Inconsistencies in research design arising from data classification methods and consensus about unit of analysis, and agreement on the choice of a consistent modeling method can lead to confusion in the selection of appropriate models for different inundation scenarios. To address these concerns, this study aims to expand on the Frequency Ratio Method, using 13 quantitative and qualitative variables, as a generalizable method that can be applied consistently across larger administrative areas such as the province. The ultimate product of this is a Flood Susceptibility Index (FSI), which can be …