Digital Commons Network^™

Effect Of Esketamine On Hypotension In Women With Preoperative Anxiety Undergoing Elective Cesarean Section: A Randomized, Double-Blind, Controlled Trial, Yu Qi, Meiyan Zhou, Yaqi Dong, Wenting Zheng, Qinyu Jiang, Yanyu Li, Xinghe Wang, Jia Sun, Hai Zhou, Zhengquan Hu, Liwei Wang

Faculty, Staff and Student Publications

To investigate the effect of low-doses esketamine on spinal anesthesia-induced hypotension in women with preoperative anxiety undergoing elective cesarean section, the randomized controlled trial enrolled 120 women aged 18-35 years who preoperative State-Trait Anxiety Inventory State scores > 40, conducted from September 2022 to August 2023 in Xuzhou Central Hospital, China. Women in the esketamine group received a single intravenous injection of 0.2 mg/kg esketamine after sensory block level achieved. The incidence of hypotension in the esketamine group was significantly lower than the control group at T2 (10% [6 of 60]; P < 0.001), T3 (5.0% [3 of 60]; P = 0.007) and T4(5.0% [3 of 60]; P = 0.004). Despite being higher in the esketamine group, the overall rates of hypertension (11.7% [7 of 60]; P = 0.186), tachycardia (23.3% [14 of 60]; P = 0.246), and bradycardia (0.0% [0 of 60]; P = 0.079) were no significantly difference between the two groups. STAI-S scores was significantly lower in the esketamine group (mean [SD] 37.52[7.14]) than in the control group (mean [SD] 41.03[9.66], P = 0.39) in postoperative day 1. Spinal anesthesia combined with intravenous low-doses esketamine infusion can significantly reduce the incidence of hypotension in women with preoperative anxiety undergoing elective cesarean section.

Nocturnal Paroxysmal Dystonia To Sleep-Related Hypermotor Epilepsy: A Critical Review, Neel Fotedar, Hans O. Lüders

Faculty Scholarship

Sleep-related paroxysmal motor episodes (SPMEs) have been described by various names, including nocturnal paroxysmal dystonia, nocturnal frontal lobe epilepsy (NFLE), and sleep-related hypermotor epilepsy. The underlying pathophysiology has been debated over the years, with these episodes assumed to be a form of paroxysmal dystonia or parasomnia versus a form of epilepsy. In most studies published on SPMEs and their variants (paroxysmal arousals, nocturnal paroxysmal dystonia, and episodic nocturnal wanderings) in the early 1990s, the authors speculated on the pathophysiology but did not commit to one idea. It was not until the mid-1990s that epilepsy became the leading prospect. We performed …

Social Media Addiction And Psychological Well-Being Among Adolescents In Malaysia: A Preliminary Study In Testing Mediating Effect Of Social Support, Ling Chong Shue, Xin Tiong Sheena Yin

Research Publications (2021 to 2025)

Malaysia is experiencing exponential increase of social media users and adolescents contribute substantially to this phenomenon. As adolescents are considered to be the most vulnerable age group in relation with psychosocial issues, we seek to determine if problematic use of social media affects psychological health and sleep of adolescents. We also seek to examine if social support mediate the said relationships.

The Implementation Of A Care And Communication Bundle For End-Of-Life Patients, Brendalee Carty Obiorah

Dissertations

Research studies have noted an improvement in end-of-life (EOL) patient's quality of life (QOL) from hospice. However, little research has been conducted to explore how the involvement of hospice care affects those in an assisted living facility (ALF). The purpose of this quantitative, pre and post-test quasi experimental design DPI project was to see to what degree a relationship exists between the care and communication bundle (independent variable) implementation and QOL (dependent variable) for 20 EOL patients on hospice in an ALF in Central Georgia. Jean Watson theory of caring and the theoretical domains framework (TDF) guided this project. The …

Understanding The Structure Of Digital Health And The Epic System In Healthcare, Blaise B. Nieve

General Submissions: Presentations (Oral and Poster)

Digital health represents the convergence of digital technologies with healthcare to enhance the efficiency, effectiveness, and personalization of medical services. This lecture delves into the expansive domain of digital health, exploring its components, significance, and transformative potential.

A User-Centered Data Visualization Of Atherosclerotic Heart Disease Risk Factors, Sandra Rivas, Tonita Powell-Fontenot, Abayomi Adegunlehin, Yang Gong

Faculty, Staff and Student Publications

High cholesterol levels significantly contribute to the risk of atherosclerotic cardiovascular disease (ACVD), with a notable portion of ischemic heart disease cases linked to elevated cholesterol levels. Effective graphical displays of lipid panel tests and other cardiac risk factors are crucial for quick and accurate data interpretation, enabling early intervention for individuals with hyperlipidemia. Applying design theories such as Gestalt and distributed cognitive theories is essential for creating user-centered graphical data displays in the context of cardiovascular (CV) risk factors. The proposed dashboard informed by these theories is expected to help healthcare providers better address cardiovascular disease (CVD), enhancing diagnosis, …

Enhancing Maude Database Utility By Gpt-4 And Cause-Effect Visualization, Yue Yu, Yuheng Shi, Yubo Feng, Yang Gong

Faculty, Staff and Student Publications

The MAUDE database is a valuable public resource for understanding malfunctions and adverse events related to medical devices and health IT. However, its extensive data and complex structure pose challenges. To overcome this, we have developed an automated analytical pipeline using GPT-4, a cutting-edge large language model. This pipeline is intended to efficiently extract, categorize, and visualize safety events with minimal human annotation. In our analysis of 4,459 colonoscopy reports from MAUDE (2011-2021), the events were categorized into operational, human factor, and device-related. Ishikawa diagrams visualized a subset stored in a vector database for easy retrieval and comparison through a …

The Value Of Cybersecurity Investment In Electronic Health Records (Ehrs, Ansu Katta

Walden Dissertations and Doctoral Studies

Senior healthcare IT leaders concerned about cybersecurity in electronic health records (EHR) continue to face fundamental challenges when efficiently managing EHR cybersecurity infrastructures to fulfill business objectives. Grounded in the updated DeLone and McLean information system success model, the purpose of this quantitative multiple linear regression study was to examine relationships between information quality, system quality, service quality, and user satisfaction related to cybersecurity and cloud computing infrastructures for EHR. The participants were 161 senior healthcare IT leaders in North and South Carolina who completed a survey that used an instrument scale based on ISS. The results of the multiple …

The Experiences Of Jamaican Secondary School Counselors Who Provide Psychological Support To Adolescents, Onnica Morris

Walden Dissertations and Doctoral Studies

School counselors play an integral role in helping adolescents navigate and overcome the psychological distress that they experience. This study aimed to better understand the experiences of Jamaican school counselors who provide psychological support to adolescents in high school. Urie Bronfenbrenner’s (2006) bioecological model of human development and Hans-Georg Gadamer's (1981) hermeneutic theory formed the conceptual framework for this study. Seven Jamaican secondary school counselors who provide psychological support to adolescents in high school participated in semistructured interviews via the Zoom online platform. Narrative analysis was used to code and analyze the data from the interviews. Seven themes emerged from …

Employing Reflexivity In Sexuality Socialisation Research: A Methodological Contribution From Psychosocial Studies, Lisa Saville Young Dr, Yanela Ndabula Ms, Catriona Ida Macleod Prof

The Qualitative Report

In this paper, we describe and demonstrate the value of adopting a psychosocial methodology to explore unique sexual socialisation experiences emphasising the role of reflexivity. Psychosocial methodology emerges from Psychosocial Studies, a “transdisciplinary” area interested in phenomena from “both” a social and personal perspective and in this paper is employed to investigate how sexual socialisation is shaped by psychological processes “and” social relations, and how these can be “thought together” (Frosh & Vyrgioti, 2022). Psychosocial data analytic strategies involve applying narrative and discursive psychology alongside psychoanalytic concepts to understand the possible reasons for a participant’s investment in particular discourses, understanding …

Impact Of A Pharmacist-Led Hcv Treatment Program At A Federally Qualified Health Center, Jerika T. Lam, Sharon Xavioer

Pharmacy Faculty Articles and Research

Pharmacists are key players who can help to eliminate the hepatitis C virus (HCV) epidemic in the United States. This pilot retrospective study evaluated the impact of a pharmacist-led HCV treatment program in a federally qualified health center (FQHC) primary care clinic setting. The primary outcome was to assess sustained virologic response (SVR) rates 12 weeks after patients were initiated and completed their oral direct acting antiviral (DAA) treatment regimens. Methods: This pilot retrospective study included historical analyses of patients who received DAA treatment in the pharmacist-led HCV treatment program in a FQHC clinic between 1 January 2019 and 31 …

Sublime And Extended Reality Experiences To Enhance Emotional Wellbeing For Autistic People: A State Of The Art Review And Narrative Synthesis, Chris Bennewith, Johara Bellali, Lance Watkins, Samuel Tromans, Kamaldeep Bhui, Rohit Shankar

More Faculty of Arts, Humanities and Business Research

Background: Sublime is a centuries old concept of emergent experience arising from immense and threatening awareness provoked by overwhelming fear and dread when faced with an incomprehensible situation as is common to autistic people. Extended Reality (XR) technologies have been used since the mid-1990s, in regulating emotions, behaviour and supporting social skill development for autistic people. Aims: To understand utility of XR technologies in creating immersive experiences for autistic people to alleviate anxiety and the relationship to the sublime. Method: A State of the Art literature review and narrative synthesis was conducted. PubMed, CINAHL, EMBASE, Cochrane Library, Scopus, Web of …

Increasing Access To Orthopedic Providers In Dickson City, Samantha Simmers, Dene Palazzi-Khan Mba, B.Sc, Kathryn Paone, Ashleigh Solomon, Aidan Alco, Matthew Smith

Research Scholars

No abstract provided.

Differential Impact Of Serotonin Signaling Methylphenidate On Young Versus Adult: Insights From Behavioral And Dorsal Raphe Nucleus Neuronal Recordings From Freely Behaving Rats, Nachum Dafny, Gloria M Elizondo, Cruz Perez-Vasquez

Faculty, Staff and Student Publications

Methylphenidate (MPD) remains a cornerstone pharmacological intervention for managing ADHD, yet its increasing usage among ordinary youth and adults outside clinical contexts necessitates a thorough investigation into its developmental effects. This study seeks to simultaneously investigate the behavioral and neuronal changes within the dorsal raphe (DR) nucleus, a center of serotonergic neurons in the mammalian brain, before and after the administration of varying doses of acute and chronic MPD in freely behaving young and adult rats implanted with DR recording electrodes. Wireless neuronal and behavioral recording systems were used over 10 consecutive experimental days. Eight groups were examined: saline, 0.6, …

Intuitive Data Visualization For Enhanced Patient Comprehension, Samina Asfandiyar, Shelley Hough, Vivian Agugo, Juliana J Brixey, Yang Gong

Faculty, Staff and Student Publications

The pilot study explores how data visualization influences patient comprehension and engagement in understanding hyperlipidemia test results across diverse patient groups. Employing Gestalt theory and the Relational Information Display (RID) framework, intuitive visual tools were developed using Google Sheets, QlikView®, and Microsoft® Excel®. The survey conducted with patients used a Likert scale to evaluate six different line and bar graphs, each presenting the same LDL cholesterol data. The study emphasized the creation of graphs that were easily interpretable. The survey aimed to assess preferences for various data visualization formats. The survey results indicated that patients preferred stacked area charts, while …

Tailored Approach To Participant Recruitment And Retention To Maximize Health Equity In Pediatric Cancer Research., Carolyn R. Bates, Renee M. Gilbert, Kelsey Dean, Keith August, Christie A. Befort, Shallyn Ward, Mary Gibson, Meredith Dreyer

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Lack of diversity in participants throughout the research process limits the generalizability of findings and may contribute to health disparities. There are unique challenges to recruitment of families to pediatric cancer research studies, especially for those from disadvantaged backgrounds. Thus, there is a need to evaluate the most effective recruitment and retention strategies to optimize equitable recruitment of diverse participants.

METHODS: The present study adapted and implemented methods outlined previously in the literature. These previous efforts were developed to address barriers to pediatric research, behavioral health intervention research and research with Black adolescents. Recruitment and retention strategies are described …

Differential Lipid Binding Specificities Of Rap1a And Rap1b Are Encoded By The Amino Acid Sequence Of The Membrane Anchors, Mussie K Araya, Wei Chen, Yuepeng Ke, Yubin Zhou, Alemayehu A Gorfe, John F Hancock, Junchen Liu

Faculty, Staff and Student Publications

RAP1 proteins belong to the RAS family of small GTPases that operate as molecular switches by cycling between GDP-bound inactive and GTP-bound active states. The C-terminal anchors of RAP1 proteins are known to direct membrane localization, but how these anchors organize RAP1 on the plasma membrane (PM) has not been investigated. Using high-resolution imaging, we show that RAP1A and RAP1B form spatially segregated nanoclusters on the inner leaflet of the PM, with further lateral segregation between GDP-bound and GTP-bound proteins. The C-terminal polybasic anchors of RAP1A and RAP1B differ in their amino acid sequences and exhibit different lipid binding specificities, …

Ay 2024/2025 Sec Meeting Minutes, 2024-07-24, Faculty Senate

Faculty Senate Archives

No abstract provided.

Pathological Response And Survival Outcomes After Neoadjuvant Chemotherapy With Radical Cystectomy In Octogenarians For Muscle-Invasive Bladder Cancer: An Observational Database Study, Arjun Pon Avudaiappan, Pushan Prabhakar, Muni Rubens, Rohan Garje, Ahmed Eldefrawy, Murugesan Manoharan

All Publications

Background: Neoadjuvant chemotherapy (NAC) with radical cystectomy (RC) is the preferred first-line treatment for localized muscle-invasive bladder cancer (MIBC). In recent years, octogenarians have been undergoing RC uneventfully, but studies showed older adults receive NAC less often. We studied the utilization and effect of RC with or without NAC in octogenarians and compared survival outcomes between responders and non-responders.

Methods: In our retrospective study using the National Cancer Database (NCDB), we identified octogenarians with MIBC and urothelial histology who underwent RC with or without NAC between 2004 and 2018. The NAC cohort included patients who underwent RC with NAC, and …

Connecting Ecosystem Services Research And Human Rights To Revamp The Application Of The Precautionary Principle, Holly J. Niner, Elisa Morgera, Andrea Longo, Kerry L. Howell, Siân E. Rees

School of Biological and Marine Sciences

With ecosystem services (ES) vital for human wellbeing¹, the protection of nature is a human rights matter. We outline how recent advances in international human rights law should inform a revamp of how precaution is applied within environmental decision-making. Critically, precautionary decision-making must evolve to make use of best-available evidence, including novel ES research approaches, to assess ‘foreseeable’ harms to all aspects of human wellbeing that are protected as human rights.

Formulation, Manufacture, And Deployment Of A Sustainable Multi-Layer Agricultural Mulch Film, Yvan David Hernandez-Charpak

Theses

Agricultural mulching films (AMF) increase crop yield while reducing pesticides use, meeting the needs of a growing world population. However, their disposal options have led to an intensifying and concerning problem of plastic pollution. Biodegradable mulch films are available, but adoption has been limited because of their unpredictable degradation rate, making them unreliable compared to conventional polyethylene AMF. This dissertation presents a multi-layer film structure (commonly used in the packaging industry), its manufacture, deployment in the field, and comprehensive sustainability assessment. Its structure consists of a thick middle layer of thermoplastic starch (TPS) and biochar filled-biodegradable poly(butylene adipate-co-terephthalate) (PBAT) thin …

Nurse Leaders Promoting Well-Being Through Mindfulness, Laura G. Cockrell

Walden Dissertations and Doctoral Studies

Becoming a nurse is not just a career but a calling. With this calling comes an ethical duty to the patient, but the duty remains to provide care for oneself. During the COVID-19 pandemic, a strained nursing profession felt the effects of a self-care deficiency. Mindfulness is one self-care tool that can allow nurses to maintain a state of well-being. This project followed Orem’s self-care deficit theory, in which people can use self-care to maintain wellness. The purpose of this project was to develop, deliver, and evaluate an education program for registered nurse leaders on mindfulness activities to address whether …

A Light-Responsive Neural Circuit Suppresses Feeding, Hailan Liu, Na Qu, Natalia Valdez Gonzalez, Marco A Palma, Huamin Chen, Jiani Xiong, Abhinav Choubey, Yongxiang Li, Xin Li, Meng Yu, Hesong Liu, Longlong Tu, Nan Zhang, Na Yin, Kristine Marie Conde, Mengjie Wang, Jonathan Carter Bean, Junying Han, Nikolas Anthony Scarcelli, Yongjie Yang, Kenji Saito, Huxing Cui, Qingchun Tong, Zheng Sun, Chunmei Wang, Xing Cai, Li Lu, Yang He, Yong Xu

Faculty, Staff and Students Publications

Light plays an essential role in a variety of physiological processes, including vision, mood, and glucose homeostasis. However, the intricate relationship between light and an animal's feeding behavior has remained elusive. Here, we found that light exposure suppresses food intake, whereas darkness amplifies it in male mice. Interestingly, this phenomenon extends its reach to diurnal male Nile grass rats and healthy humans. We further show that lateral habenula (LHb) neurons in mice respond to light exposure, which in turn activates 5-HT neurons in the dorsal Raphe nucleus (DRN). Activation of the LHb→5-HTDRN circuit in mice blunts darkness-induced hyperphagia, while inhibition …

Pannexin-1 Channel Inhibition Alleviates Opioid Withdrawal In Rodents By Modulating Locus Coeruleus To Spinal Cord Circuitry, Charlie H T Kwok, Tamara Markovic, Nicolas Massaly, Hye Jean Yoon, Jose A Morón, Et Al.

2020-Current year OA Pubs

Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinue chronic opioid use. The locus coeruleus (LC) is an important autonomic centre within the brain with a poorly defined role in opioid withdrawal. We show here that pannexin-1 (Panx1) channels expressed on microglia critically modulate LC activity during opioid withdrawal. Within the LC, we found that spinally projecting tyrosine hydroxylase (TH)-positive neurons (LC

Instrumentation Failure In Adult Spinal Deformity Patients, David P Falk, Ravi Agrawal, Bijan Dehghani, Rohit Bhan, Sachin Gupta, Munish C Gupta

2020-Current year OA Pubs

In recent years, advances in the surgical treatment of adult spinal deformity (ASD) have led to improved outcomes. Although these advances have helped drive the development of deformity surgery to meet the rising volume of patients seeking surgical treatment, many challenges have yet to be solved. Instrumentation failure remains one of the most common major complications following deformity surgery, associated with significant morbidity due to elevated re-operation rates among those experiencing mechanical complications. The two most frequently encountered subtypes of instrumentation failure are rod fracture (RF) and proximal junctional kyphosis/proximal junctional failure (PJK/PJF). While RF and PJK/PJF are both modes …

India's Use Of Public-Private Partnerships To Promote Rapid Expansion Of Solar Electricity Facilities, Karen Consalo

Florida Journal of International Law

This Article will explore the use of PPPs to encourage the flow of private capital and expertise toward development of low-carbon, low-pollution, sustainable energy generation in India to achieve the country’s ambitious goal of creating 175 gigawatts of renewably sourced electricity by 2022. The lessons in India’s extensive use of PPPs to achieve such ambitious electricity goals should serve as a model for other governments to engage the private sector to successfully develop solar and other renewable energy projects with limited risk but with significant benefits for their citizens.

Criminality & Imprisonment Policy Lessons From Across The Pond: Comparing Europe And The United States, Jonathan Link

Florida Journal of International Law

In the wake of the death of George Floyd and the national and international outcry for racial justice that followed, it seems inevitable that criminal justice reform in America is on the horizon. U.S. President Joe Biden has recognized that there “absolutely” is systemic racism in law enforcement.1 He went on to argue that the U.S. prison system should “turn into a rehabilitation system, not . . . just punishment.” In these interview statements and various other campaign speeches, Presidential debates, and Presidential press conferences since, the President has made clear that the way that the U.S. punishes crime needs …

Dairy Production From Pasture In Southern China, P.N P. Matthews, J Hodgson, A.C P. Chu, W L. Jiang, C B. Luo

IGC Proceedings (1977-2023)

This paper covers the development of dairy production systems as part of the UNDP funded Agro-grasslands Systems Development Project in Guizhou Province, China. The basic philosophy for the project was for local adaptation of New Zealand technology for developing dairy production systems based on pastures. The dairy production systems were established and the outputs of the project successfully achieved. Net incomes of smallholder farmers increased from a baseline of RMB $140 to RMB $1740 per annum over a three year period. Based on the experienced gained in setting up these systems local researchers, administrators, extension personnel and smallholders were able …

Forage-Based Seasonal Dairying In South Louisiana, H A. Deramus, L Labbe, K Ingawa, W A. Atkinson, M J. Simon, J D. Roussel

IGC Proceedings (1977-2023)

The effects on the net profit and total milk production were compared using two levels of grain supplementation and forage-only feeding in a program of seasonal dairying in South Louisiana using management intensive grazing. Treatments were 8 kg grain, 4 kg grain, and 0 grain supplementation. Annual ryegrass (Lolium multiflorium) and clovers (Trifolium incarnatum, and T. Alexandrinum) were grazed intensively with 51 multiparous Jersey and Holstein cows in mid-lactation in 1993-1995. Milk production, milk fat, milk protein, and blood urea nitrogen were measured. Milk and protein models were all highly significant for all classes. Daily milk …

Meet An Ipe/Cp Alumna Champion, Oreoluwa James, Mph

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

This past academic year I had the opportunity to participate in the Jefferson Student Interprofessional Complex Care Collaborative (J-SICCC). I worked with a team of four other Jefferson students from different academic programs to be a student advocate for a patient. Our team worked with her on managing some of her health concerns and goals such as a regimen for her diabetic medication and resources regarding medication disposal, social support, and mental health services. I also participated as a student moderator for Community Voices with Pastor Shawn Edmonds and facilitated his panel on the very important topic of mental health …