Digital Commons Network^™

Taste And See That The Lord Is Good, Stephen Larson

Consensus

No abstract provided.

Csf1r Inhibition Depletes Brain Macrophages And Reduces Brain Virus Burden In Siv-Infected Macaques, Diana G. Bohannon, Laurent D. Zablocki-Thomas, Evan S. Leung, Jinbum K. Dupont, Julian B. Hattler, Jolanta Kowalewska, Miaoyun Zhao, Jiangtao Luo, Marco Salemi, Angela M. Amedee, Qingsheng Li, Marcelo J. Kuroda, Woong-Ki Kim

School of Graduate Studies Faculty Publications

Perivascular macrophages (PVMs) and, to a lesser degree, microglia are targets and reservoirs of HIV and simian immunodeficiency virus (SIV) in the brain. Previously, we demonstrated that colony-stimulating factor 1 receptor (CSF1R) in PVMs was upregulated and activated in chronically SIV-infected rhesus macaques with encephalitis, correlating with SIV infection of PVMs. Herein, we investigated the role of CSF1R in the brain during acute SIV infection using BLZ945, a brain-penetrant CSF1R kinase inhibitor. Apart from three uninfected historic controls, nine Indian rhesus macaques were infected acutely with SIVmac251 and divided into three groups (n = 3 each): an untreated control and …

Geriatric Emergency Medicine Fellowship Journal Club: Strategies For Success In Geriatric Emergency Medicine Research, Priyank Bhatnagar, Lauren Southerland, Ula Hwang, Jacques Lee

Journal of Geriatric Emergency Medicine

n/a

A Systematic Study Of The Distribution And Expression Of Aquaporin Water Channels In Normal Adult Human Brain, Oyinkansola Mudasiru, Vivian Etugbo, Reginald Adiele

School of Podiatric Medicine - Student Research

Water regulation in the central nervous system (CNS) is very crucial to maintain normal neurophysiological homeostasis, intracranial pressure and play a role in the pathogenesis of edema and brain disorders. Not only because of the rigidity and limited mobility of the brain encasement that offer little room for fluid expansion, but also the need to maintain an appropriate osmotic balance across the various fluid-filled brain compartments which is necessary for normal neurological functions. Aquaporins (AQPs), a family of non-energy dependent, bidirectional water transport protein channels, play a critical role in maintaining water and electrolyte balance in human brain. The distribution …

Sex Influences Of Age Of Onset And Duration Of Illness On Patterns Of Cortical Thickness In Individuals With Schizophrenia, Rachael Olivia Slate

Theses and Dissertations

Given that the manifestation of schizophrenia varies by sex, it is hypothesized that the interaction between diagnosis and sex significantly influences brain structure and is believed to be a crucial factor in understanding the neurobiology of schizophrenia. While much is known about cortical thickness mapping of the condition, there is currently no work that has assessed how changes to the cortical mantle relate to important clinical features of schizophrenia that vary by sex, such as age of illness onset (AOO) or duration of illness (DOI). This study utilized a sex-wise approach to examining cortical thickness alterations in men and women …

Comparing The Clinical Features Of Lateral And Medial Approaches Of Costoclavicular Technique Versus Traditional Lateral Sagittal Technique As Infraclavicular Brachial Plexus Block Methods: A Randomized Controlled Trial, Emre Sertaç Bingül, Mert Canbaz, Mehmet Güzel, Emine Aysu Şalvız, Bora Edim Akalın, Ömer Berköz, Ebru Emre Demirel, Zerrin Sungur, Meltem Savran Karadeniz

2020-Current year OA Pubs

BACKGROUND: It is aimed to compare the block onset times and performance features of costoclavicular techniques (medial and lateral approach) versus lateral sagittal technique.

METHODS: Patients were randomized into three groups. For costoclavicular techniques, ultrasound probe was placed parallel to clavicle obtaining nerve cords, axillary artery and axillary vein visual from lateral-to-medial, respectively. The block needle was advanced from lateral (Group CLB) or medial (Group CMB) to perform costoclavicular block. For lateral sagittal technique (Group LSB), ultrasound probe was placed sagittal and perpendicular below the coracoid process to obtain sagittal artery image with the cords around. Total 20 ml of …

A Correctable Immune Niche For Epithelial Stem Cell Reprogramming And Post-Viral Lung Diseases, Kangyun Wu, Yong Zhang, Huiqing Yin-Declue, Kelly Sun, Dailing Mao, Kuangying Yang, Stephen R. Austin, Erika C. Crouch, Steven L. Brody, Derek E. Byers, Christy M. Hoffmann, Michael E. Hughes, Michael J. Holtzman

2020-Current year OA Pubs

Epithelial barriers are programmed for defense and repair but are also the site of long-term structural remodeling and disease. In general, this paradigm features epithelial stem cells (ESCs) that are called on to regenerate damaged tissues but can also be reprogrammed for detrimental remodeling. Here we identified a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population that functioned as an early sentinel niche for basal ESC reprogramming in mouse models of epithelial injury after respiratory viral infection. Niche function depended on moDC delivery of ligand GPNMB to the basal ESC receptor CD44 so that properly timed antibody blockade of ligand or receptor …

Review Of The Impact And Burden Of Urinary Urgency On Adults With Overactive Bladder, Adrian Wagg, A Lenore Ackerman, H Henry Lai, Diane K. Newman

2020-Current year OA Pubs

No abstract provided.

A Place To Rest My Soul: How A Doctoral Student Of Color Group Utilized A Healing-Centered Space To Navigate Higher Education, Jessica I. Ramirez

School of Social Work Faculty Publications and Presentations

Students of Color have historically faced explicit and implicit forms of discrimination and oppression in educational settings. Unfortunately, not much has changed over the decades as Students of Color continue to experience white supremacy and other systems of oppression. As Students of Color enter graduate school, there are often fewer Students of Color, making these educational settings isolating and hostile. These experiences often encompass white supremacist policies, practices, and remarks that negatively impact Students of Color. With this in mind and as someone who identifies as a Chicana who was once in a doctoral program, I questioned how doctoral Students …

Annular Rupture During Transcatheter Aortic Valve Replacement Without A Surgical Option–The Double-Edged Sword Of Mechanical Circulatory Support, Aishah Matar, Corey Adams, Anna Bizios, Rosaleen Chun, Jillian Colbert, Daniel Holloway, Ayaaz K. Sachedina

Journal of Shock and Hemodynamics

Transcatheter aortic valve replacement (TAVR) has become a well-established treatment option for patients with severe aortic stenosis. With advances in the field and positive outcomes in clinical trials, TAVR use has expanded from being limited to older patients with prohibitive surgical risk to younger patients with intermediate and low surgical risk. As operators’ experiences have grown and technology has evolved, there are fewer TAVR complications. However, when complications do occur, they remain associated with significant morbidity and mortality. Aortic annulus rupture is a catastrophic complication of TAVR. Risk factors for annulus rupture include valve oversizing, female gender, a large calcification …

Trade, Usury, And The Incursion Of Desire, Allen Jorgenson

Consensus

No abstract provided.

Health For All: A Doctor’S Prescription For A Healthier Canada, John Milloy

Consensus

No abstract provided.

Genome-Wide Methylation Patterns In Primary Uveal Melanoma: Development Of Methylsig-Um, An Epigenomic Prognostic Signature To Improve Patient Stratification, Emilie Lalonde, Dong Li, Kathryn Ewens, Carol L. Shields, Arupa Ganguly

Wills Eye Hospital Papers

Despite studies highlighting the prognostic utility of DNA methylation in primary uveal melanoma (pUM), it has not been translated into a clinically useful tool. We sought to define a methylation signature to identify newly diagnosed individuals at high risk for developing metastasis. Methylation profiling was performed on 41 patients with pUM with stage T2-T4 and at least three years of follow-up using the Illumina Infinium HumanMethylation450K BeadChip (N = 24) and the EPIC BeadChip (N = 17). Findings were validated in the TCGA cohort with known metastatic outcome (N = 69). Differentially methylated probes were identified in patients who developed …

Optimizing Lumpfish Rearing, Nicholas Gosling

UNH Today Archive

No abstract provided.

A Culturally Informed Mentorship Model For Historically Underrepresented Ethnic Minority Advanced Practice Registered Nursing Students, Lonnie P. Herring

Dissertations

Ethnic minority students pursuing advanced practice nursing degrees often face unique challenges that hinder their academic success and persistence, such as limited mentorship opportunities that address their cultural considerations. A lack of culturally informed mentorship (CIM) may contribute to feelings of isolation, lower self-efficacy, and reduced retention rates among ethnic minority advanced practice registered nursing (APRN) students. Through cultural competency, CIM programs are emerging as a promising approach to address these challenges and support the needs of historically underrepresented ethnic minority (HUEM) students. The underrepresentation of HUEM APRN students in graduate nursing education and advanced nursing practice is a persistent …

Exploring Students' Perceptions And Experiences Of Faculty Caring In The Undergraduate Classroom In A Traditional Baccalaureate Nursing Program: A Qualitative Descriptive Study, Sheila M. Garilli

Dissertations

Academic nurse educators' use of caring attributes in the classroom could impact students' educational journey. Educators are leaders who should model caring behaviors toward their students. This role modeling will empower students to demonstrate these caring behaviors toward their patients. A literature review discovered a gap surrounding the study of faculty caring in the classroom. This research study explored students' perceptions and experiences of faculty caring in the undergraduate classroom in two traditional baccalaureate nursing programs. This study utilized a qualitative descriptive method with purposeful sampling and in-person recruitment at two universities in a Northeastern state in the United States. …

Evaluating Mental Health Provider Self-Efficacy In Identifying Body Image Disturbance In Adult Female Patients Taking Antidepressents And Antipsychotics: A Quality Improvement Project, Raymonda Augustin

DNP and Student Works

This project aimed to assess provider self-efficacy in identifying BID among adult female patients using antidepressants and antipsychotics, employing the Body Image Disturbance Questionnaire (BIDQ) within a framework inspired by Albert Bandura's Self-Efficacy Theory.

Me-Em Enewsbrief, June 2024, Department Of Mechanical Engineering- Engineering Mechanics, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.

Tert Activation Targets Dna Methylation And Multiple Aging Hallmarks, Hong Seok Shim, Jonathan Iaconelli, Xiaoying Shang, Jiexi Li, Zheng D Lan, Shan Jiang, Kayla Nutsch, Brittney A Beyer, Luke L Lairson, Adam T Boutin, Michael J Bollong, Peter G Schultz, Ronald A Depinho

Faculty, Staff and Student Publications

Insufficient telomerase activity, stemming from low telomerase reverse transcriptase (TERT) gene transcription, contributes to telomere dysfunction and aging pathologies. Besides its traditional function in telomere synthesis, TERT acts as a transcriptional co-regulator of genes pivotal in aging and age-associated diseases. Here, we report the identification of a TERT activator compound (TAC) that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC-induced elevation of TERT levels promotes telomere synthesis, blunts tissue aging hallmarks with reduced cellular senescence and inflammatory cytokines, and silences p16INK4a expression via upregulation of DNMT3B-mediated promoter hypermethylation. In the brain, …

Antiformer: Graph Enhanced Large Language Model For Binding Affinity Prediction, Qing Wang, Yuzhou Feng, Yanfei Wang, Bo Li, Jianguo Wen, Xiaobo Zhou, Qianqian Song

Faculty, Staff and Student Publications

Antibodies play a pivotal role in immune defense and serve as key therapeutic agents. The process of affinity maturation, wherein antibodies evolve through somatic mutations to achieve heightened specificity and affinity to target antigens, is crucial for effective immune response. Despite their significance, assessing antibody-antigen binding affinity remains challenging due to limitations in conventional wet lab techniques. To address this, we introduce AntiFormer, a graph-based large language model designed to predict antibody binding affinity. AntiFormer incorporates sequence information into a graph-based framework, allowing for precise prediction of binding affinity. Through extensive evaluations, AntiFormer demonstrates superior performance compared with existing methods, …

Chilled Classrooms: Educator Identity And Responses To "Divisive Issues"-Related Challenges To Professionalism, Hannah Katherine Dixon Everett

Theses and Dissertations

Recently, the United States has seen a notable increase in controversy and legislation regarding "divisive" concepts and issues in education. These divisive issues include Critical Race Theory, Social Emotional Learning, book censorship, and other race and gender topics. Legislation and media coverage regarding these issues contributes to a larger trend of challenges to teacher professionalism. I build on recent literature exploring how educators experience divisive issues legislation, putting these experiences in conversation with educator identity formation and the development of a professional sense of self. I interviewed 18 secondary school teachers throughout Utah's Wasatch Front to explore (1) how teachers …

Amber Montgomery, An Individual, Appellant/ Cross-Appellee V. Dr. Jeffrey P. Gardiner, D.O., An Individual, And Utah Valley Eye Center, Inc., A Utah Corporation, Appellees/ Cross-Appellants : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from a Final Order and Judgment of the Fourth Judicial District Court in and for Utah County, State of Utah Trial Judge Robert Lund

ATTORNEYS FOR APPELLANT, Justin D. Heideman, Justin R. Elswick

ATTORNEYS FOR APPELLEES, Kirk G. Gibbs, Gary T. Wight

Stratasys Printed 3-D Mandibular Molar With Tooth Anatomy And Texture, M. Austin White, Charles E. Taylor, Edwin Kee, Albert F. Mcmullen

School of Dentistry Faculty Publications

Introduction: We used CBCT scans of a human mandibular molar in concert with the Stratasys 3-D printer to fabricate said teeth with similar texture and hardness to enamel, dentin, and cementum. The printed tooth should also have the same crown and root anatomy, as well as root canal anatomy of the scanned tooth. Methods: One mandibular first molar was scanned (Carestream Dental CS 9600 CBCT) and printed (Stratasys 3D multi-material printer). A (Micromet 5104) hardness tester was used to test the hardness of the printed tooth. Nine combinations of two different materials (Stratasys’ Vero Pure White and Agilus 30 Clear …

Midweek Memo, Georgia Southern University

Midweek Memo

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Board Of Trustees Minutes, Jul. 25 2024, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Board Of Trustees Agenda, Jul. 25 2024, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Evaluating The Antibacterial Efficacy Of A Silver Nanocomposite Surface Coating Against Nosocomial Pathogens As An Antibiofilm Strategy To Prevent Hospital Infections, James Butler, Sian Morgan, Lewis Jones, Mathew Upton, Alexandros Besinis

School of Engineering, Computing and Mathematics

Antimicrobial nanocoatings may be a means of preventing nosocomial infections, which account for significant morbidity and mortality. The role of hospital sink traps in these infections is also increasingly appreciated. We describe the preparation, material characterization and antibacterial activity of a pipe cement-based silver nanocoating applied to unplasticized polyvinyl chloride, a material widely used in wastewater plumbing. Three-dimensional surface topography imaging and scanning electron microscopy showed increased roughness in all surface finishes versus control, with grinding producing the roughest surfaces. Silver stability within nanocoatings was >99.89% in deionized water and bacteriological media seeded with bacteria. The nanocoating exhibited potent antibiofilm …

Vaccine Value Profile For Hookworm, Karl Philipp Puchner, Maria Elena Bottazzi, Victoria Periago, Martin Grobusch, Rick Maizels, James Mccarthy, Bruce Lee, Erika Gaspari, David Diemert, Peter Hotez

Faculty, Staff and Students Publications

Hookworm, a parasitic infection, retains a considerable burden of disease, affecting the most underprivileged segments of the general population in endemic countries and remains one of the leading causes of mild to severe anemia in Low and Middle Income Countries (LMICs), particularly in pregnancy and children under 5. Despite repeated large scale Preventive Chemotherapy (PC) interventions since more than 3 decades, there is broad consensus among scholars that elimination targets set in the newly launched NTD roadmap will require additional tools and interventions. Development of a vaccine could constitute a promising expansion of the existing arsenal against hookworm. Therefore, we …

Randomized, Double-Blind, Placebo-Controlled Study Of Anti-Mycobacterial Therapy (Rhb-104) In Active Crohn's Disease, David Y Graham, Saleh A Naser, Thomas Borody, Zbigniew Hebzda, Harry Sarles, Scott Levenson, Robert Hardi, Tomasz Arłukowicz, Petar Svorcan, Reza Fathi, Aida Bibliowicz, Patricia Anderson, Patrick Mclean, Clara Fehrmann, M Scott Harris, Shuhong Zhao, Ira N Kalfus

Faculty, Staff and Students Publications

This study, conducted between 4 October 2013, and 30 November 2018, tested the hypothesis that triple antimicrobial therapy, targeting Mycobacterium avium subspecies paratuberculosis (MAP), long considered a putative cause, would favorably affect Crohn’s disease. A double-blind multicenter study of adults with active Crohn’s disease, (i.e., Crohn’s Disease Activity Index [CDAI] 220–450 plus C-reactive protein ≥ 1.0 mg/dL, fecal calprotectin (FCP) >162.9 µg/g stool, or recent endoscopic or radiographic confirmation of active disease) receiving concomitant standard-of-care Crohn’s disease treatment (Clinicaltrials.gov: NCT01951326) were stratified by anti-tumor necrosis factor use and randomized (1:1) to anti-MAP RHB-104 (clarithromycin 95 mg, rifabutin 45 mg, …

An Expert System On Flimsy Foundations: Teaching Expertise And The Early Career Framework, Jim Hordern, Katherine Evans, Pete Kelly, Nick Pratt

School of Law, Humanities and Social Sciences

The paper seeks to identify how teacher expertise is implicitly and explicitly conceptualised in current English education policy in respect of the professional development of teachers. We focus specifically on conceptualisations of expertise in the Early Career Framework (ECF), both in terms of the policy documentation produced by the Department for Education and in terms of a selection of publicly available materials produced by the lead providers of the ECF. We aim to locate these conceptualisations in terms of broader sociological and philosophical debates about the nature of expertise and its relationship to professional work, in addition to recent research …