Digital Commons Network^™

The F Plasmid Conjutome: The Repertoire Of E Coli Proteins Translocated Through An F-Encoded Type Iv Secretion System, Abu Amar M Al Mamun, Kimberley Kissoon, Yang Grace Li, Erin Hancock, Peter J Christie

Faculty, Staff and Student Publications

Bacterial conjugation systems pose a major threat to human health through their widespread dissemination of mobile genetic elements (MGEs) carrying cargoes of antibiotic resistance genes. Using the Cre Recombinase Assay for Translocation (CRAfT), we recently reported that the IncFV pED208 conjugation system also translocates at least 16 plasmid-encoded proteins to recipient bacteria. Here, we deployed a high-throughput CRAfT screen to identify the repertoire of chromosomally encoded protein substrates of the pED208 system. We identified 32 substrates encoded by the Escherichia coli W3110 genome with functions associated with (i) DNA/nucleotide metabolism, (ii) stress tolerance/physiology, (iii) transcriptional regulation, or (iv) toxin inhibition. …

More Autonomy For Frontline Workers Supports Higher-Paying Jobs, Dylan Nelson, Nathan Wilmers, Letian Zhang

Employment Research Newsletter

No abstract provided.

Improving First Case On-Time Starts In The Operating Room, Lojy Koshy

Master's Projects and Capstones

Problem: A timely first-case start in the operating room (OR) is critical for optimizing departmental efficiency and resource utilization. Persistent delays in first-case start times disrupt the surgical schedule, leading to suboptimal OR use, diminished patient and staff satisfaction, reduced operational efficiency, and decreased overall productivity. Addressing these delays is essential to enhance the quality and efficiency of surgical services.

Context: The microsystem for this project is a Northern California operating room that handles a high volume of surgical procedures. There are 10 operating rooms, and the goal is to have 70% of first cases in the operating room on …

Diagnosis And Management Of Hypertension In Adolescents With Obesity, Shradha M. Chhabria, Sarah D. Ronis, Courtney E. Batt

Faculty Scholarship

Purpose of Review: Hypertension (HTN) and obesity are increasing in prevalence and severity in adolescents and have significant implications for long term morbidity and mortality. This review focuses on the diagnosis and management of HTN in adolescents with obesity with an emphasis on co-management of the two conditions. Recent Findings: Recent studies affirm the increasing prevalence of abnormal blood pressures and diagnoses of HTN associated with increased adiposity. Current guidelines recommend routine screening with proper technique for HTN in patients with obesity. Additionally, obesity and HTN related co-occurring medical conditions should be evaluated as there is frequently a bidirectional impact …

Consumer Perceptions And Preferences For Utah Fresh And Packaged Fruit, Makaylie Langford, Kynda R. Curtis, Marcelo Pignatari

All Current Publications

In this fact sheet, we discuss the results of a 2023 study examining Utah consumer perceptions and preferences for Utah fresh and packaged fruit products. Study data were collected online via a Qualtrics survey, and 384 Utah adults completed the survey. Utah consumer food behaviors and attitudes, including participation in food and agricultural tourism activities, are discussed. We analyze the most consumed fruits and the preferred purchasing options for various fruit types, such as packaged, frozen, canned, and fresh. Additionally, we explore the factors influencing consumers’ decisions when buying fruit and review the product information they rely on. Overall, the …

Fruit Production And Opportunities For Growers In Utah, Makaylie Langford, Kynda R. Curtis

All Current Publications

This fact sheet discusses the state of the fruit industry in Utah, its impact on the Utah economy, as well as current challenges the fruit industry faces and opportunities for fruit growers moving forward. These challenges and opportunities underscore the importance of fruit to the state’s economy, as growers navigate urbanization, competition, and consumer preferences for locally grown produce. Fostering collaboration between consumers and growers will ensure a commitment to local agriculture and community support.

Fruit Consumption Indicators: Who Consumes More Fruit In Utah?, Makaylie Langford, Kynda R. Curtis

All Current Publications

This fact sheet discusses fruit consumption patterns in Utah, exploring the key demographic and socioeconomic factors linked to increased fruit intake. Fruit growers and marketers can use this information to design effective promotional campaigns targeting consumers more likely to purchase fruit and fruit products.

Capturing Hidden Narratives With Metadata And Digital Storytelling, Angela Yon, Emily Baldoni, Maddi Loiselle

Faculty and Staff Publications – Milner Library

Digital collections provide an information space capable for complex data analysis and visualizations. A metadata strategy with robust description can reach beyond providing access to a collection and inspire new contextual narratives and knowledge. Using the Illinois State Normal University (ISNU) World War I Service Records digital collection as a case study, the authors explored the collections as data model in this significant World War I archival collection to highlight lesser-known stories, including those of the Pioneer Infantry, women, and noncombatants. Through the creation and analysis of metadata, transcription, and images in the collection, a digital exhibit was produced using …

A Review Of Fault Detecting Devices For Belt Conveyor Idlers, Fahad Alharbi, Suhuai Luo

Journal of Mechanical Engineering Science and Technology (JMEST)

The shift towards automated inspection methods represents considerable progress in conveyor system maintenance, enhancing safety and efficiency while posing challenges in data analysis and implementation costs. This study critically analyses sensor technologies and inspection methods for detecting faults in conveyor belt idlers, highlighting their essential role in preserving the operational integrity of industrial conveyor systems. By synthesizing various research findings, the study assesses the effectiveness of different sensor devices in identifying defects, including built-in sensors, fixed sensor options like acoustic, ultrasonic sensors, cameras, accelerometers, and Distributed Optical Fibre Sensors (DOFS), as well as mobile sensor systems. Our findings emphasize the …

Effect Of Addition Titanium Dioxide Nanoparticle On Properties Of Pineapple Leaf Fiber Mediated Tempo Oxidation, Rahmad Ikrom Ramadhan, Heru Suryanto, Ahmad Atif Fikri, Aminnudin Aminnudin, Jibril Maulana, Faqih Fadillah, Mohamed T. Mito, Kemal Masera

Journal of Mechanical Engineering Science and Technology (JMEST)

Indonesia is an agricultural country with the potential to grow many plants as natural fiber sources. In order to improve its properties, natural fiber needs to be treated by applying nanomaterial so that it can compete with the characteristics of synthetic fibers. The study aims to determine the influence of adding titanium dioxide (TiO2) nanoparticles on pineapple leaf fiber (PALF) characteristics. The PALF was collected from the Subang plantation (Indonesia). The chemical treatment was carried out with pre-treatment using an alkalization process for 3 hours, and the oxidation process was carried out with TEMPO. TiO2 nanoparticle grafting was carried out …

Heuristic Approach To Comparing The Environmental Impacts Of Carbon Nanotube Production Methods, Ahmad Atif Fikri, Irham Fadlika, Albarrobi Nabila Saeful, Krisna Dwipa Muhdi, Daniel Febrian Pratama, Nasir Garba Bello

Journal of Mechanical Engineering Science and Technology (JMEST)

Carbon Nanotubes (CNTs) production so far has its own advantages and disadvantages. Some methods that can be used in producing CNTs are chemical vapor deposition (CVD), laser ablation, and arc discharge. The three methods have their own requirements, this causes different environmental impacts on each method. Studies into the environmental impact of the CNTs production process found that during thermal pretreatment of the reactant gas, more than 45 by-products were formed, including methane, volatile organic compounds, and polycyclic aromatic hydrocarbons. Calculating the environmental impact of CNTs production method often has challenges in implementation, because each production process has different systems …

Study Of A Remote Wind Resource Assessment System Integrated With Internet Of Things, Filian Arbiyani, Filbert Filbert, Anthony Nathanael Theo

Journal of Mechanical Engineering Science and Technology (JMEST)

Wind energy is an emerging and popular source of clean energy due to its non-polluting nature and low cost. The efficient use of wind energy requires accurate and precise wind parameter measurements, which is where wind resource assessment (WRA) comes into play. The IoT and cloud-based systems have been applied to remote monitoring systems and provide crucial solutions for data acquisition, storage, and analytics in wind energy technology. This study aims to build a remote WRA system integrated with the Internet of Things. This study utilizes an Arduino Uno microcontroller, RK100-01 wind speed sensor, BMP280 temperature and pressure sensor, and …

The Isr Downstream Target Atf4 Represses Long-Term Memory In A Cell Type-Specific Manner, Niaz Mahmood, Jung-Hyun Choi, Pei You Wu, Sean W Dooling, Trent A Watkins, Ziying Huang, Jesse Lipman, Hanjie Zhao, Anqi Yang, Jake Silversmith, Yanis Inglebert, Constantinos Koumenis, Vijendra Sharma, Jean-Claude Lacaille, Wayne S Sossin, Arkady Khoutorsky, R Anne Mckinney, Mauro Costa-Mattioli, Nahum Sonenberg

Faculty, Staff and Students Publications

The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long-term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), a key downstream effector of the ISR, in various neuronal and non-neuronal cell types. We found that the removal of ATF4 from forebrain excitatory neurons (but not from inhibitory neurons, cholinergic neurons, or astrocytes) enhances LTM formation. Furthermore, the deletion of ATF4 in …

Pins, Inhwan Jeon

Theses

Pins aims to portray the societal landscape observed and experienced by me as an international student, highlighting sociological concerns like hatred and hate crimes instead of focusing on surface-level metrics such as the risk and fatality rates of COVID-19. Through this work, I want to remind the audience of the multifaceted nature of society and the emotions evoked by COVID-19, prompting reflection on the role of art during times of crisis. While transforming my original medium of metal objects into an installation art format, I explored concepts such as spacing, installation, cognition, narrative, and multiple senses. I integrated these elements …

Gemykibivirus Detection In Acute Encephalitis Patients From Nepal, Eans Tara Tuladhar, Smita Shrestha, Susan Vernon, Lindsay Droit, Kathie A Mihindukulasuriya, Mamta Tamang, Lata Karki, Annie Elong Ngono, Bimlesh Jha, Bal Krishna Awal, Bimal Sharma Chalise, Runa Jha, Sujan Shresta, David Wang, Krishna Das Manandhar

2020-Current year OA Pubs

UNLABELLED: Acute encephalitis syndrome (AES) causes significant morbidity and mortality worldwide. In Nepal, Japanese encephalitis virus (JEV) accounts for ~5-20% of AES cases, but ~75% of AES cases are of unknown etiology. We identified a gemykibivirus in CSF collected in 2020 from an 8-year-old male patient with AES using metagenomic next-generation sequencing. Gemykibiviruses are single stranded, circular DNA viruses in the family

IMPORTANCE: Viral encephalitis is a devastating disease, but unfortunately, worldwide, the causative virus in many cases is unknown. Therefore, it is important to identify viruses that could be responsible for cases of human encephalitis. Here, using metagenomic sequencing …

Lipidomic Risk Score To Enhance Cardiovascular Risk Stratification For Primary Prevention, Jingqin Wu, Corey Giles, Aleksandar Dakic, Habtamu B. Beyene, Kevin Huynh, Tingting Wang, Thomas Meikle, Gavriel Olshansky, Agus Salim, John Blangero

School of Medicine Publications

Background

Accurate risk stratification is vital for primary prevention of cardiovascular disease (CVD). However, traditional tools such as the Framingham Risk Score(FRS) may underperform within the diverse intermediate-risk group, which includes individuals requiring distinct management strategies.

Objectives

This study aimed to develop a lipidomic-enhanced risk score (LRS), specifically targeting risk prediction and reclassification within the intermediate group, benchmarked against the FRS.

Methods

The LRS was developed via a machine learning workflow using ridge regression on the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab; n = 10,339). It was externally validated with the Busselton Health Study (n = 4,492), and …

Computer Simulation Of Catheter Cryoablation For Pulmonary Vein Isolation, Solange I. Rivera, Clara P. Bernal, Rafael Martínez-Peláez, Rogelio Robledo-Nolasco, Gerardo De León-Larios, Vanessa G. Félix, Rodolfo Ostos, Gladys Maestre, Jesus Melgarejo, Luis J. Mena

School of Medicine Publications

Cryoablation is a well-established medical procedure for surgically treating atrial fibrillation. Cryothermal catheter therapy induces cellular necrosis by freezing the insides of pulmonary veins, with the goal of disrupting abnormal electrical heart signals. Nevertheless, tissue damage induced by cold temperatures may also lead to other complications after cardiac surgery. In this sense, the simulation of catheter ablation can provide safer environments for training and the performance of cryotherapy interventions. Therefore, in this paper, we propose a novel approach to help better understand how temperature rates can affect this procedure by using computer tools to develop a simulation framework to predict …

Establishing Consensus For Mohs Micrographic Surgical Techniques In The Treatment Of Melanoma In Situ For Future Clinical Trials: A Modified Delphi Study, Kristen K Curtis, Nathan J Fakult, Jennifer L Strunck, Sumaira Z Aasi, Christine S Ahn, Murad Alam, Anna A Bar, Ramona Behshad, Christopher K Bichakjian, Diana Bolotin, Susan L Boone, Jeremy S Bordeaux, Jerry D Brewer, David R Carr, John A Carucci, Jason R Castillo, Sean R Christensen, Melanie A Clark, Lindsey K Collins, Addison M Demer, Daniel B Eisen, Hao Feng, Bahar F Firoz, Roy C Grekin, Jason M Hirshburg, Todd E Holmes, Conway C Huang, Thomas A Jennings, Shang I Brian Jiang, Sailesh Konda, Justin J Leitenberger, Jesse M Lewin, Ian A Maher, Elise Ng, Ida F Orengo, Faramarz H Samie, Drew K Saylor, Victoria Rose Sharon, Teo Soleymani, Susan M Swetter, Jesalyn A Tate, Marta J Van Beek, Nahid Y Vidal, Alok Vij, Ashley Wysong, Yaohui Gloria Xu, Bryan T Carroll, Wesley Y Yu

Faculty, Staff and Students Publications

Background: Mohs micrographic surgery (MMS) is a promising treatment modality for melanoma in situ (MIS). However, variations in surgical technique limit the generalizability of existing data and may impede future study of MMS in clinical trials.

Methods: A modified Delphi method was selected to establish consensus on optimal MMS techniques for treating MIS in future clinical trials. The Delphi method was selected due to the limited current data, the wide range of techniques used in the field, and the intention to establish a standardized technique for future clinical trials. A literature review and interviews with experienced MMS surgeons were performed …

Exploring The Impact Of Electrocardiographic Parameters On The Risk Of Common Arrhythmias: A Two-Sample Mendelian Randomization Study, Guangheng Wu, Qiaoyun Zhang, Jie Zhang, Jinqi Zhu, Deqiang Zheng, Youxin Wang, Lijuan Wu

Research outputs 2022 to 2026

Background: Observational studies have shown that heart rate (HR), heart rate variability (HRV), P-wave terminal force, P-wave duration, T-wave amplitude and PR interval are associated with risk factors for atrial fibrillation (AF) or bradycardia. Arrhythmias are associated with many causes of hospitalization. However, observational studies are susceptible to confounding factors that have not yet been identified. The objective of this study was to clarify the causal relationships by Mendelian randomization analysis. Methods: We conducted a two-sample and multivariate Mendelian randomization (MVMR) analysis using genome-wide association study (GWAS) data from a European population to assess the total and direct causal effects …

Waking Up The Snake: Ancient Wisdom For Regeneration, Anne Poelina, Bill Webb, Sandra Wooltorton, Naomi Joy Godden

Research outputs 2022 to 2026

The Anthropocene exposes the colonial paradox: ‘that Indigenous people were right all along, that landscapes are neither inert nor mute, but imbued with vitality’ (Ghosh, 2021, p 256). Now, humans must speak out to represent the vital living earth, to return persons of all species to cultures, stories and places. This is called ‘Waking up the Snake’ – using the ancient wisdom of our places to awaken the consciousness of the people to their obligations of stewardship through an ethic of care and love. Serpent goes by many names, being integral to Australia’s Earth Dream, a 65,000-year-old story of sentient …

Impact Of Esophageal Motility On Microbiome Alterations In Symptomatic Gastroesophageal Reflux Disease Patients With Negative Endoscopy: Exploring The Role Of Ineffective Esophageal Motility And Contraction Reserve, Ming-Wun Wong, I-Hsuan Lo, Wei-Kai Wu, Po-Yu Liu, Yu-Tang Yang, Chun-Yao Chen, Ming-Shiang Wu, Sunny H Wong, Wei-Yi Lei, Chih-Hsun Yi, Tso-Tsai Liu, Jui-Sheng Hung, Shu-Wei Liang, C Prakash Gyawali, Chien-Lin Chen

2020-Current year OA Pubs

BACKGROUND/AIMS: Ineffective esophageal motility (IEM) is common in patients with gastroesophageal reflux disease (GERD) and can be associated with poor esophageal contraction reserve on multiple rapid swallows. Alterations in the esophageal microbiome have been reported in GERD, but the relationship to presence or absence of contraction reserve in IEM patients has not been evaluated. We aim to investigate whether contraction reserve influences esophageal microbiome alterations in patients with GERD and IEM.

METHODS: We prospectively enrolled GERD patients with normal endoscopy and evaluated esophageal motility and contraction reserve with multiple rapid swallows during high-resolution manometry. The esophageal mucosa was biopsied for …

Treatment Response With Potassium-Competitive Acid Blockers Based On Clinical Phenotypes Of Gastroesophageal Reflux Disease: A Systematic Literature Review And Meta-Analysis, Seungyeon Seo, Hye-Kyung Jung, C Prakash Gyawali, Hye Ah Lee, Hyung Seok Lim, Eui Sun Jeong, Seong Eun Kim, Chang Mo Moon

2020-Current year OA Pubs

BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is typically managed based on the clinical phenotype. We evaluated the efficacy and safety of potassium-competitive acid blockers (PCABs) in patients with various clinical GERD phenotypes.

METHODS: Core databases were searched for studies comparing PCABs and proton pump inhibitors (PPIs) in clinical GERD phenotypes of erosive reflux disease (ERD), non-erosive reflux disease (NERD), PPI-resistant GERD and night-time heartburn. Additional analysis was performed based on disease severity and drug dosage, and pooled efficacy was calculated.

RESULTS: In 9 randomized controlled trials (RCTs) evaluating the initial treatment of ERD, the risk ratio for healing with PCABs versus …

Gabaa Receptor Subunit Composition Regulates Circadian Rhythms In Rest–Wake And Synchrony Among Cells In The Suprachiasmatic Nucleus, Daniel Granados-Fuentes, Peter Lambert, Tatiana Simon, Steven Mennerick, Erik D Herzog

2020-Current year OA Pubs

The mammalian circadian clock located in the suprachiasmatic nucleus (SCN) produces robust daily rhythms including rest-wake. SCN neurons synthesize and respond to γ-aminobutyric acid (GABA), but its role remains unresolved. We tested the hypothesis that γ2- and δ-subunits of the GABA

Advocate Christ Hospital And Medical Center Year-In-Review Report, 2000, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2000. Includes data, statistics, news, and development plans.

Advocate Christ Medical Center Year-In-Review Report, 2001, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2001. Includes data, statistics, news, and development plans.

Advocate Christ Medical Center Year-In-Review Report, 2002, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2002. Includes data, statistics, news, and development plans.

Advocate Christ Medical Center Year-In-Review Report, 2003, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2003. Includes data, statistics, news, and development plans.

Advocate Christ Medical Center Year-In-Review Report, 2004, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2004. Includes data, statistics, news, and development plans.

Differences In Cardiorespiratory Responses With Three Set-Paced Submaximal Endurance Tests In Community-Dwelling Older Adults, Konrad J. Dias, Renee’ S. Rhyne, Danielle M. Callahan, Kaitlyn N. Durbin, Abigail R. Kasten, Jill Heitzman, Dustin R. Nadler

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1026-1037, 2024. A variety of submaximal exercise tests are commonly used in clinical practice to determine an individual’s exercise capacity and cardiorespiratory fitness. This study explored differences in cardiorespiratory and perceived exertion responses following the completion of three set-paced exercise tests. A prospective, observational, cross-sectional design assessed 30 healthy community-dwelling older adults, who participated in three submaximal exercise tests, including seated marching (SM), standing marching (STM), and standing stepping (STS). Each test was three minutes in length and required the participant to step at a set pace. Heart rate (HR), blood pressure (BP), rate …

Advocate Christ Medical Center Year-In-Review, 2005, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2005, subtitled "Portraits of Excellence". Includes data, statistics, news, and development plans.