Digital Commons Network^™

Exploring The Pdz, Duf, And Lim Domains Of Pdlim5 In Dendrite Branching, Yogesh Srivastava, Maxsam Donta, Lydia L Mireles, Adriana Paulucci-Holthauzen, Leilei Shi, Mark T Bedford, M Neal Waxham, Pierre D Mccrea

Faculty, Staff and Student Publications

The branched architecture of neuronal dendrites is a key factor in how neurons form ordered networks and discoveries continue to be made identifying proteins and protein-protein interactions that direct or execute the branching and extension of dendrites. Our prior work showed that the molecular scaffold Pdlim5 and delta-catenin, in conjunction, are two proteins that help regulate the branching and elongation of dendrites in cultured hippocampal neurons and do so through a phosphorylation-dependent mechanism triggered by upstream glutamate signaling. In this report we have focused on Pdlim5's multiple scaffolding domains and how each contributes to dendrite branching. The three identified regions …

Interpreting Ppv And Npv Of Diagnostic Tests With Uncertain Prevalence, Yakov Ben-Haim, Clifford C Dacso

Faculty, Staff and Students Publications

OBJECTIVE: Medical decision-making is often uncertain. The positive predictive value (PPV) and negative predictive value (NPV) are conditional probabilities characterizing diagnostic tests and assessing diagnostic interventions in clinical medicine and epidemiology. The PPV is the probability that a patient has a specified disease, given a positive test result for that disease. The NPV is the probability that a patient does not have the disease, given a negative test result for that disease. Both values depend on disease incidence or prevalence, which may be highly uncertain for unfamiliar diseases, epidemics, etc. Probability distributions for this uncertainty are usually unavailable. We develop …

Incomplete Faces Do But Masked Faces Do Not Affect Mind Perception, Farid Pazhoohi, Keina Aoki, Alan Kingstone

School of Psychology

The human face plays a critical role in how we perceive the minds of others. The current research across two studies explored whether face masks also impact mind perception, with the expectation that they lead to lower attributions of agency and experience to individuals, making them seem less mentally capable due to their association with reduced facial expression perception and impaired communication. In the first study, participants’ ratings of masked and unmasked faces for agency and experience did not yield significant differences, suggesting that wearing a face mask does not affect the perception of the mind. To explore whether these …

3d Printed Mounts For Liquid Microdroplet Resonators, Parker A. Awerkamp

Theses and Dissertations

Liquid microdroplet resonators provide an excellent tool for optical studies due to their innate smoothness and high quality factors, but they can be difficult to control. By using 3D printed mounts to support the droplets, we can obtain precise control over the droplet geometries and positions. We here present our work with oil, water, and ice microdroplets, as well as tools required to enable their study. We first present methods for creating 3D printed mounts for oil microdroplet resonators. The mounts enable precise positioning of the droplets relative to a tapered optical fiber. The oil microdroplet resonators exhibited quality factors …

Potential Targeting Mechanisms For Bone-Directed Therapies, Betul Celik, Andrés Leal, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Bone development is characterized by complex regulation mechanisms, including signal transduction and transcription factor-related pathways, glycobiological processes, cellular interactions, transportation mechanisms, and, importantly, chemical formation resulting from hydroxyapatite. Any abnormal regulation in the bone development processes causes skeletal system-related problems. To some extent, the avascularity of cartilage and bone makes drug delivery more challenging than that of soft tissues. Recent studies have implemented many novel bone-targeting approaches to overcome drawbacks. However, none of these strategies fully corrects skeletal dysfunction, particularly in growth plate-related ones. Although direct recombinant enzymes (e.g., Vimizim for Morquio, Cerezyme for Gaucher, Elaprase for Hunter, Mepsevii for …

Utah Consumer Preferences And Willingness To Pay For Specialty Labeled Fruit Products, Kynda R. Curtis, Makaylie Langford, Marcelo Pignatari

All Current Publications

In this fact sheet, we discuss the results of a 2023 study examining Utah consumer preferences and willingness to pay (WTP) for fruit products labeled local (Utah’s Own™), organic, and GMO-free. We discuss and compare survey respondents' past consumption, awareness, preferences, and attitudes toward these labeling programs. Additionally, we examine consumer WTP values for each of these labels for three fruit varieties and fresh and dried products, namely fresh apples, strawberries, and dried tart cherries.

Exploring The Dutch Bruynzeel Kitchen Through The Negotiations Of Its Two Designers, Limperg And Zwart, Selin Geerinkcx, Els De Vos

Interiority

During the interwar period, numerous endeavours were made to develop a rational kitchen, also called a laboratory kitchen, namely one that prioritised labour-saving efficiency through thoughtful layout and design. Catherine Beecher's work is often credited as its starting point. By synthesising household reformers' experiences and architects’ design expertise, scholars have extensively examined how rational kitchens evolved. This paper discusses the conception of the standardised Dutch Bruynzeel Kitchen (1938) by the collaborative efforts of two designers with distinct yet complementary interior design profiles. Renowned Dutch designer Piet Zwart, widely recognised for his contributions, finalised the technical drawings and promotional materials for …

Impacts Of Managed Honeybee Apiaries On Native Bee Populations, Trapping Efficiencies Of Bee Sampling Methods, And Drone Based Floral Cover Analysis In High Elevation Tall Forb Communities In Central Utah, Nicholas Val Anderson

Theses and Dissertations

This dissertation investigates the impact of honeybee introductions on native bee populations, evaluates the efficiency of traditional bee sampling and monitoring methods, and explores the use of drone technology for assessing floral resources on federal lands in the United States. Federal lands, managed for multiple uses, present a valuable opportunity for the summer pasturing of honeybees. These lands produce vast floral resources and are largely free from pesticides and other pollutants that could weaken honeybee populations. The potential use of this resource is significant given the economic and agricultural concerns presented by declining pollinator trends and Colony Collapse Disorder (CCD). …

Functional & Evolutionary Analysis Of Tbx2a And Tbx2b In Zebrafish Heart Development, Maliha Tasnim

Theses and Dissertations

Congenital Heart Disease (CHD) is the most common birth defect, affecting approximately 1% of live births. This dissertation explores the genetic mechanisms underlying CHD, focusing on the T-box transcription factors Tbx2a and Tbx2b in zebrafish. Utilizing advanced bioinformatics techniques, we reconstructed the ancestral sequences of these genes to understand their evolutionary trajectory and functional divergence. Our analysis highlights the evolutionary conservation of the DNA-binding domain in tbx2a and tbx2b, suggesting its crucial role in maintaining correct gene expression patterns during development. We observed unique and shared amino acid substitutions in these proteins, indicating potential adaptive changes and conserved functions. Comparative …

Seattle’S Paid Sick Leave Law Increased Work Hours Without Affecting Job Attachment, Hilary Wething, Meredith Slopen

Employment Research Newsletter

No abstract provided.

Osland, Joyce S., San Jose State University

Emeritus and Retired Faculty Biographies

Case Western Reserve University, 1990 Ph.D.

University of Washington, 1972 MSW

Social Welfare, University of Minnesota, 1970 B. A.

The Interaction Of Endorepellin And Neurexin Triggers Neuroepithelial Autophagy And Maintains Neural Tube Development, Lei Lu, Meizhu Bai, Yufang Zheng, Xiukun Wang, Zhongzhong Chen, Rui Peng, Richard H Finnell, Tongjin Zhao, Chengtao Li, Bo Wu, Yunping Lei, Jinsong Li, Hongyan Wang

Faculty, Staff and Students Publications

Heparan sulfate proteoglycan 2 (HSPG2) gene encodes the matrix protein Perlecan, and genetic inactivation of this gene creates mice that are embryonic lethal with severe neural tube defects (NTDs). We discovered rare genetic variants of HSPG2 in 10% cases compared to only 4% in controls among a cohort of 369 NTDs. Endorepellin, a peptide cleaved from the domain V of Perlecan, is known to promote angiogenesis and autophagy in endothelial cells. The roles of enderepellin in neurodevelopment remain unclear so far. Our study revealed that endorepellin can migrate to the neuroepithelial cells and then be recognized and bind with the …

Evaluation Of Machine Learning Algorithms And Statistical Analysis For Predicting Crash Severity And Determining Contributing Factors: A Comparative Study, Arian Golrokh Amin

Civil Engineering ETDs

Improving road traffic safety relies on the ability to accurately predict traffic crashes and understand the factors contributing to severe injuries. This study employs a dual approach, utilizing both statistical analysis and machine-learning methodologies. Initially, statistical analyses such as chi-squared tests and Cramer's V values are applied to a decade's worth of police report data from Albuquerque, New Mexico, to identify primary causal factors behind crashes. Subsequently, machine-learning models are developed and rigorously compared to predict the severity of traffic crash injuries. The selection of the most effective algorithm is based on comprehensive metrics including accuracy, precision, recall, and F1 …

Thermal Oxidative Degradation Of Polystyrene Plastics Used For Food Packaging During Incomplete Waste Incineration, Maycee Hurd

Civil Engineering ETDs

We identified the physical and chemical degradation of polystyrene (PS) plastic used for food packaging after thermal oxidative weathering. Open waste incineration is a widely used waste management practice in isolated and underserved communities. However, the generation of partially incinerated plastics and microplastics (MPs) from this practice is overlooked. Near surface XPS C 1s high resolution analyses show an increase in the intensity of peaks greater than 285 eV corresponding to C/O bonds after burning of PS. Bulk analyses using ATR-FTIR show that thermal oxidation decreased the alkene (3040-3000 cm-1) and alkane (3000-2850 cm-1) C-H stretch signals suggesting PS chain …

A Quality Improvement Project: Implementing A Mental Health Screening Program For International Business Travelers., Joyce Ighedosa

Doctor of Nursing Practice Final Project Abstract

A Quality Improvement Project: Implementing a Mental Health Screening Program for International Business Travelers.

PURPOSE The purpose of the Quality Improvement project was to implement a mental health screening program for international business travelers in an oil and gas organization. The Patient Health Questionnaire (PHQ-2) was implemented

BACKGROUND The project was implemented in a global oil and gas organization. The original medical screening for pre-travel preparation was on identification of physiological disorders, proper management of identified disease processes; infectious disease prevention; vaccine review and update; malaria chemoprophylaxis and vector control. Mental Health was not reviewed.

METHODOLOGY The PHQ-2 was …

Cherokia Georgiana Mitogenome Sequencing And Analysis, William Wittstock

Biology Theses

Despite the vast diversity of millipedes, complete genomic and mitogenomic data available in public databases is limited, hindering comprehensive studies on their classification, evolution, and genetics. Among the underrepresented taxa are the Xystodesmidae, a family comprising approximately 500 species with minimal mitogenomic data, and no complete genomes sequenced. Our research involves sequencing the mitochondrial genome of Cherokia georgiana, a representative of this diverse family with interesting traits that are not clearly defined at a genetic level. This research also serves as a pilot study to develop DNA extraction methods and protocols for whole genome sequencing. Multiple DNA extraction kits …

Pekerja Anak Di Kawasan Timur Indonesia Tahun 2022: Kondisi Dan Faktor Yang Memengaruhi, Muhammad Rafii Al Muflih, Yuliagnis Transver Wijaya

Jurnal Ekonomi Kependudukan dan Keluarga

In 2019-2022, the percentage of child labor in eastern Indonesia has consistently been higher than in western Indonesia. However, research specifically focusing on child labor in eastern Indonesia is limited. This study aims to examine the conditions and factors influencing child labor in eastern Indonesia. Utilizing data from the August 2022 Indonesia National Labor Force Survey (Sakernas), the study employs descriptive analysis and binary logistic regression. Findings reveal that 5-6 out of 100 children in eastern Indonesia are engaged in child labor. Predominantly, they work in agriculture, forestry, and fisheries, though there are regions where most are employed in other …

Pengaruh Orang Tua, Keluarga, Dan Lingkungan Sosial Terhadap Perilaku Merokok Remaja, Nurul Hidayati, Dwini Arianto

Jurnal Ekonomi Kependudukan dan Keluarga

The high prevalence of teenage smoking in Indonesia is a serious problem. This study aims to analyze the influence of the smoking behavior of close individuals to teenagers, including parents, family, and social environment, on the smoking behavior of teenagers in Indonesia. Using the National Socioeconomic Survey (SUSENAS) 2021 Data, with a sample of 187,277 adolescent individuals. The results of this study indicate that the smoking behavior of parents, family, and a smoking environment has a significant positive influence on teenage smoking behavior. Parents who smoke increase the likelihood of teenagers smoking by 1.61 times, while smoking family members also …

Social Vulnerabilities In Head-Neck Melanoma Care: A Retrospective Cohort Study In The United States, Lillian Mccampbell, David Jun Fei-Zhang, Daniel Chelius, Ling-Lun Bob Hsia, Robert Dellavalle, Jill D'Souza, David Bentrem, Jeffrey Wayne, Jeffrey Rastatter, Anthony Sheyn

School of Medicine Faculty Publications

BACKGROUND: Studies addressing social determinants of health (SDH) in head-neck melanomas (HNM) have only assessed socioeconomic factor impact but not a wider scope of SDH. OBJECTIVE: Utilizing the Social Vulnerability Index (SVI), to assess the influence of specific SDH and their quantifiable associations with HNM management disparities across the varied community contexts in the United States. METHODS: This retrospective cohort study analyzed adults diagnosed with HNM from 1975 to 2017 from the Surveillance, Epidemiology, and End Results Program database. RESULTS: A total of 374,138 HNM in adults from 1975 to 2017 were assessed for disparities affiliated with increasing overall vulnerability/SVI …

Empowering Patient Care Technicians To Reduce Non-Ventilated Hospital-Acquired Pneumonia In An Acute Care Hospital In Northern California, Barbra Pacatang

Master's Projects and Capstones

Abstract

Problem: Non-ventilator hospital-acquired pneumonia (nv-HAP) is increasingly becoming a significant concern in healthcare settings. Studies have indicated that nv-HAP accounts for a substantial portion of hospital-acquired pneumonia cases, with a high associated mortality rate. The prevalence of nv-HAP underscores the importance of implementing robust HAP prevention bundles. Prevention, early recognition, and appropriate management of nv-HAP are essential to improve patient outcomes and reduce the burden on healthcare facilities.

Context: A 28-bed capacity Stroke Telemetry Unit incurred six nv-HAP incidents in 2023. Patients needed to be more compliant with the nv-HAP prevention bundles. Patient care technicians (PCTs) are instrumental nurses’ …

Statistical Methods For Predicting E-Cigarette Use Events Based On Beat-To-Beat Interval (Bbi) Data Collected From Wearable Devices, James J Yang, Megan E Piper, Premananda Indic, Anne Buu

Faculty, Staff and Student Publications

The prevalence of e-cigarette use among young adults in the USA is high (14%). Although the majority of users plan to quit vaping, the motivation to make a quit attempt is low and available support during a quit attempt is limited. Using wearable sensors to collect physiological data (eg, heart rate) holds promise for capturing the right timing to deliver intervention messages. This study aims to fill the current knowledge gap by proposing statistical methods to (1) de-noise beat-to-beat interval (BBI) data from smartwatches worn by 12 young adult regular e-cigarette users for 7 days; and (2) summarize the de-noised …

“How I Dress Is No One’S Business!”: Fashion As A Subversive Language Of Resistance Among Female Christian Celebrities In Ghana, Amanda E. Gyesi

Communication ETDs

Influenced by burgeoning literature on feminism and feminist theories, specifically within the African context, I analyze the intersection of religion and celebrity culture among a select group of women in Ghana. Using the African feminist critical discourse analysis, guided by Stuart Hall’s encoding and decoding model, this research examines how female Christian celebrities in Ghana enact resistance, project their agency, and shape their identities through their fashion statements and sartorial choices, hence contributing to the broader discourse on fashion communication among religious women.

Through a critical analysis of Instagram comments and YouTube interview transcripts, I argue that fashion communication among …

Grievability And The Contingency Of Life Value In Twenty-First-Century Science Fiction, Emily A. Reiff

English Language and Literature ETDs

Using Judith Butler’s framework of grievability, this dissertation explores twenty-first-century science fiction by British, Irish, and Caribbean authors whose novels grapple with legacies of colonialism and imperialism that relied on dehumanization and subjugation. Beginning with Sarah Maria Griffin’s Spare and Found Parts (2016), chapter one explores neocolonial rationales—purportedly based on health—which recreate colonial divisions of class and labor and enforce systems of diminishing grievability in a post-apocalyptic Irish context. Chapter two contends that Kazuo Ishiguro’s Klara and the Sun (2021) illustrates the danger inherent to value systems that center “normative” embodiment in worlds that reconfigure hypercapacitated human beings as the …

Application Of Geographic Information Systems (Gis) In The Study Of Prostate Cancer Disparities: A Systematic Review, Christiane J. El Khoury

Department of Medical Oncology Faculty Papers

Introduction: PCa is one of the cancers that exhibits the widest disparity gaps. Geographical place of residence has been shown to be associated with healthcare access/utilization and PCa outcomes. Geographical Information Systems (GIS) are widely being utilized for PCa disparities research, however, inconsistencies in their application exist. This systematic review will summarize GIS application within PCa disparities research, highlight gaps in the literature, and propose alternative approaches. Methods: This paper followed the methods of the Cochrane Collaboration and the criteria set of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Articles published in peer-reviewed journals were searched through …

Computational Drug Repositioning And 3d Skin-Like Tissues Identify Anti-Fibrotic Targets For Systemic Sclerosis (Ssc), Dillon Popovich

Dartmouth College Ph.D Dissertations

Systemic Sclerosis (SSc) is a rare autoimmune disease characterized by dermal and internal organ fibrosis, including heart, lungs, and gastrointestinal tract, and autoantibody formation. Although disease etiology is currently unknown, like other autoimmune diseases, SSc likely develops due to environmental factor exposure in genetically susceptible individuals. Fibrotic diseases are notoriously difficult to treat. Coupled with the autoimmune aspect, SSc is difficult to study scientifically due to the lack of complex disease models that can recapitulate the immune-fibrotic axis of the disease. Due to this, there are only two FDA approved medical treatments for SSc approved for symptomatic treatment of SSc …

Malloy, Suzanne ( Sue), San Jose State University

Emeritus and Retired Faculty Biographies

Nova University (Ft. Lauderdale, Florida),Higher Education, 1993 Ed.D.

University of Nebraska, College of Nursing (Omaha, Nebraska), Nursing (MSN)- (Teaching Subspecialty and Med-Surg. Clinical Nurse Specialist), 1981 M.S.

University of Utah, (SLC, UT), Nursing,1979 B.S.

St. Joseph’s School of Nursing Diploma RN

Impacts Of Cellphone Usage On Adolescent Social And Emotional Development, Chelsea N. Hammer

Masters Projects

Adolescent cellphone use has a negative impact on the school environment. This project explores how cellphones effect youth social and emotional development. The literature is reviewed as it relates to cellphone usage and emotional well-being, mental health, intrapersonal skill development and interpersonal growth. Cellphone addiction amongst teenagers is discussed as well protective factors to mitigate the damage cellphone use inflicts on student social and emotional development. This project advocates for making school stakeholders aware of these harmful effects so as to consider a re-examination of school cellphone policy. Incorporating periods of unplugging during the school day as well as using …

Adaptive Fine-Tuning Based Transfer Learning For The Identification Of Mgmt Promoter Methylation Status, Erich Schmitz, Yunhui Guo, Jing Wang

Faculty, Staff and Student Publications

Background. Glioblastoma Multiforme (GBM) is an aggressive form of malignant brain tumor with a generally poor prognosis. O 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been shown to be a predictive bio-marker for resistance to treatment of GBM, but it is invasive and time-consuming to determine methylation status. There has been effort to predict the MGMT methylation status through analyzing MRI scans using machine learning, which only requires pre-operative scans that are already part of standard-of-care for GBM patients. Purpose. To improve the performance of conventional transfer learning in the identification of MGMT promoter methylation status, we developed a 3D SpotTune …

The F Plasmid Conjutome: The Repertoire Of E Coli Proteins Translocated Through An F-Encoded Type Iv Secretion System, Abu Amar M Al Mamun, Kimberley Kissoon, Yang Grace Li, Erin Hancock, Peter J Christie

Faculty, Staff and Student Publications

Bacterial conjugation systems pose a major threat to human health through their widespread dissemination of mobile genetic elements (MGEs) carrying cargoes of antibiotic resistance genes. Using the Cre Recombinase Assay for Translocation (CRAfT), we recently reported that the IncFV pED208 conjugation system also translocates at least 16 plasmid-encoded proteins to recipient bacteria. Here, we deployed a high-throughput CRAfT screen to identify the repertoire of chromosomally encoded protein substrates of the pED208 system. We identified 32 substrates encoded by the Escherichia coli W3110 genome with functions associated with (i) DNA/nucleotide metabolism, (ii) stress tolerance/physiology, (iii) transcriptional regulation, or (iv) toxin inhibition. …

More Autonomy For Frontline Workers Supports Higher-Paying Jobs, Dylan Nelson, Nathan Wilmers, Letian Zhang

Employment Research Newsletter

No abstract provided.