Digital Commons Network^™

Recruiting Transgender Men In The Southeastern United States For Genital Microbiome Research: Lessons Learned, Olivia Van Gerwen, Z. Alex Sherman, Emma Sophia Kay, Jay Wall, Joy Lewis, Isaac Eastlund, Keonte J. Graves, Saralyn Richter, Angela Pontius, Kristal J. Aaron, Krishmita Siwakoti, Ben Rogers, Evelyn Toh, Jacob H. Elnaggar, Christopher M. Taylor, Nicholas J. Van Wagoner, Christina A. Muzny

School of Medicine Faculty Publications

Background Transgender men (TGM) are underrepresented in genital microbiome research. Our prospective study in Birmingham, AL investigated genital microbiota changes over time in TGM initiating testosterone, including the development of incident bacterial vaginosis (iBV). Here, we present lessons learned from recruitment challenges encountered during the conduct of this study. Methods Inclusion criteria were assigned female sex at birth, TGM or non-binary identity, age ≥18 years, interested in injectable testosterone but willing to wait 7 days after enrollment before starting, and engaged with a testosterone-prescribing provider. Exclusion criteria were recent antibiotic use, HIV/STI infection, current vaginal infection, pregnancy, or past 6 …

The Impact Of Coach-Created Motivational Climate On Athletes’ Mental Health And The Mitigating Effects Of Psychological Safety And Psychological Resiliency, Shir Wasserman

Dissertations, 2020-current

With the growing importance of athletes’ mental health in sport, there is an escalating need for understanding the multifaceted nature of the concept, including related individual and environmental factors (Nixdorf et al., 2023). Previous studies suggest that athletes’ engagement with their social environment can potentially influence their mental health outcomes (Reis, 2001). Additionally, studies examining the coach-athlete relationship have consistently affirmed the significance of this connection to various athlete-related outcomes, including aspects of mental health and overall well-being (Jowett & Shanmagum, 2016). Therefore, this study explored the relationship between coach-created motivational climate, athletes' mental health, and the mitigating effects of …

Staff Education To Enhance Healthcare Providers' Use Of The Phq-9 Assessment Tool, Priscilia Nguh

Walden Dissertations and Doctoral Studies

Depression is a common mental health issue that has a substantial impact on people’s well-being and healthcare results. While there is ample evidence of depression’s harmful impact, the difficulty of accurate diagnosis remains. Inadequate screening of depression in primary health clinics results in treatment delays. The PHQ-9 is a tool to diagnose depression, however many clinicians are unfamiliar with its use. As a result, individuals susceptible to depression may not receive timely appropriate management, leading to poor health outcomes and higher healthcare utilization. This practice focused project aimed to understand if staff education would improve healthcare providers’ knowledge regarding use …

Relationship Between Student Physical Therapist Pain Knowledge, Beliefs, And Self-Efficacy Assessing And Treating Pain, Ryan Morgan Reed

Walden Dissertations and Doctoral Studies

Chronic pain is a debilitating condition that affects a large percentage of the population. According to recent studies, chronic pain management is best treated using a biopsychosocial (BPS) non-pharmacological approach rather than a biomedical (BM) approach. Student Physical Therapists (SPTs) trained in a BPS approach have different beliefs about pain than those trained in the BM approach. Beliefs about pain are related to pain knowledge and self-efficacy for treating pain patients. To date, no study has examined these three variables together or explored differences in BM versus BPS beliefs in relationship to the other two variables. Guided by social cognitive …

Microbial Phosphate Solubilization Mechanisms In P Solubilizing In Andisol, Agustina Erlinda Marpaung, Tengku Sabrina, Abdul Rauf, Dwi Ningsih Susilowati, Luthfi Aziz Mahmud Siregar

Jurnal Kultivasi

Phosphate (P) nutrient plays a significant role in plant growth and yield. P is an essential element that plays an important role in photosynthesis and root development. Phosphate nutrient availability is deficient in some soil types due to retention, such as in Andisol soil types. High phosphate retention in Andisol soil types causes P nutrients to be unavailable to plants and can reduce crop yields. The availability of P in Andisol soils can be done, among others, by applying phosphate solubilizing microbes. Phosphate solubilizing microorganisms are soil microorganisms consisting of bacteria and fungi that can mineralize organic P, dissolve inorganic …

Socioeconomic Determinants And Maternal Mortality In Liberia, Monee Sherman

Walden Dissertations and Doctoral Studies

High rates of pregnancies and childbirth contribute to a heightened risk of maternal mortality among women between 15 and 49 in Liberia. Most women are uninformed about their maternal risk behaviors, symptom severity, and delayed care-seeking. The mortality rate for women between 25 and 34 during pregnancy and childbirth is unacceptably high. The highest increase in maternal mortality rates is seen among women between 40 and 44 who choose to delay motherhood. In Liberia, the deaths of 4.5 women a day are caused by complications during pregnancy and childbirth. We examined the influence of participant background characteristics, socioeconomic factors, and …

Predictors Of Antisocial Behavior Among Hispanic Adults, Mara Page

Walden Dissertations and Doctoral Studies

Antisocial behavior can lead to serious social and legal consequences such as long-term involvement in criminal activities. Although there has been much research on predictors of antisocial behavior, such as perceived economic status, parental communication, impulsivity, substances, parenting styles, and parental involvement, little has been researched on how these apply to the Hispanic population. Grounded in Gottfredson and Hirschi’s general crime theory, the purpose of this nonexperimental correlational survey design study was to assess whether sensation-seeking behavior, self-control, parental monitoring, religious coping, perceived social support, and rugged resilience predicted antisocial behavior among Hispanic adults. A sample of 167 Hispanic adult …

Teachers’ Perspectives Of Readiness, Academic, And Social Skills Of First Graders Who Did Not Attend Kindergarten, Kathryn Mary Hogan

Walden Dissertations and Doctoral Studies

Research suggests that kindergarten attenders benefit from the time spent learning basic academic and social skills. Skills students learn in kindergarten lead to skills taught in first grade and school readiness; however, many children do not attend kindergarten. The problem under study was that records indicate that many students do not attend kindergarten, and so may not be ready for first grade. The purpose of this study was to explore the perspectives of first grade teachers in a southeastern U.S. state regarding the readiness for first grade of students whose entry records indicate they did not attend kindergarten. Pianta’s theory …

Brain-Targeted Intranasal Delivery Of Protein-Based Gene Therapy For Treatment Of Ischemic Stroke, Jee-Yeon Ryu, Christian D. Cerecedo-Lopez, Hongkuan Yang, Ilhwan Ryu, Rose Du

School of Medicine Publications

Gene therapy using a protein-based CRISPR system in the brain has practical limitations due to current delivery systems, especially in the presence of arterial occlusion. To overcome these obstacles and improve stability, we designed a system for intranasal administration of gene therapy for the treatment of ischemic stroke.

Methods: Nanoparticles containing the protein-based CRISPR/dCas9 system targeting Sirt1 were delivered intranasally to the brain in a mouse model of ischemic stroke. The CRISPR/dCas9 system was encapsulated with calcium phosphate (CaP) nanoparticles to prevent them from being degraded. They were then conjugated with β-hydroxybutyrates (bHb) to target monocarboxylic acid transporter 1 (MCT1) …

Pressing Issues For Oral Care Quality Improvement: Findings From The Eu Deliver Project, Paulo Melo, Leonor Frey-Furtado, Daniela Correia, Stefan Listl, Michael Lorenz, Nagihan Bostanci, Álvaro Azevedo, Maria Lurdes Pereira

Faculty, Staff and Student Publications

BACKGROUND: While oral health often takes a backseat to other health domains, it silently affects nearly half of the Worldwide population. The DELIVER project, funded by the EU's Horizon Europe program, seeks to develop a blueprint model for improving the quality of oral health care for everyone.

METHODS: Applying the Nominal Group Technique (NGT), 17 stakeholders from various backgrounds participated in identifying pressing issues for oral care quality improvement across practice, community, and policy levels.

RESULTS: The results revealed significant differences at the different levels, with accessibility emerging as a prominent issue, encompassing affordability, availability, and acceptability of oral healthcare …

Interleukin-21 Engineering Enhances Nk Cell Activity Against Glioblastoma Via Cebpd, Mayra Shanley, May Daher, Jinzhuang Dou, Sufang Li, Rafet Basar, Hind Rafei, Merve Dede, Joy Gumin, Jezreel Pantaleόn Garcίa, Ana Karen Nunez Cortes, Shan He, Corry M Jones, Sunil Acharya, Natalie W Fowlkes, Donghai Xiong, Sanjay Singh, Hila Shaim, Samantha Claire Hicks, Bin Liu, Abhinav Jain, Mohammad Fayyad Zaman, Qi Miao, Ye Li, Nadima Uprety, Enli Liu, Luis Muniz-Feliciano, Gary M Deyter, Vakul Mohanty, Patrick Zhang, Scott E Evans, Elizabeth J Shpall, Frederick F Lang, Ken Chen, Katayoun Rezvani

Faculty, Staff and Student Publications

Glioblastoma (GBM) is an aggressive brain cancer with limited therapeutic options. Natural killer (NK) cells are innate immune cells with strong anti-tumor activity and may offer a promising treatment strategy for GBM. We compared the anti-GBM activity of NK cells engineered to express interleukin (IL)-15 or IL-21. Using multiple in vivo models, IL-21 NK cells were superior to IL-15 NK cells both in terms of safety and long-term anti-tumor activity, with locoregionally administered IL-15 NK cells proving toxic and ineffective at tumor control. IL-21 NK cells displayed a unique chromatin accessibility signature, with CCAAT/enhancer-binding proteins (C/EBP), especially CEBPD, serving as …

Vascular Surgeons Widely Underrepresented In Online News Regarding Vascular Pathologies, Joshua R. Chen, Adam M. Ostrovsky, Robert Tatum, Sanath Patil, Dawn Salvatore, Paul J. Dimuzio, Michael Nooromid, Babak Abai

Department of Surgery Faculty Papers

Background: Vascular surgeons have traditionally been under-represented in various media platforms. Our study aims to characterize vascular surgeon involvement in online news coverage as it relates to vascular pathologies. Methods: Google news was queried for news articles published between July 31, 2022, and August 1, 2023, using 11 keywords (“carotid stenosis,” “carotid artery disease,” “dialysis fistula,” “abdominal aortic aneurysm,” “aortic dissection,” “varicose vein,” “deep vein thrombosis,” “peripheral vascular disease,” “peripheral arterial disease,” “limb ischemia,” and “claudication). Unrelated articles and medical press under a paywall were excluded. Article and represented physician demographic information were collected. Representation was defined as being the …

Unilateral Facial Swelling In A Sickle Cell Patient., Rohan Akhouri, Alison L. Fowler, Colton Schwarz, Lina Patel

Manuscripts, Articles, Book Chapters and Other Papers

Acute soft head syndrome (ASHS) is a rare complication of sickle cell disease that often requires a high index of suspicion and is often a diagnosis of exclusion. We present the case of an 18-year-old male with sickle cell disease in the United States who developed acute soft head syndrome without known traumatic injury. The goal of this case presentation is to provide awareness and education regarding a rare complication of sickle cell disease and recommended management for the associated symptoms.

The Effects Of A High-Fat Meal Challenge With Polyphenol And Fiber On Postprandial Insulin And C-Peptide In Prediabetics: A Pilot Study, Gabrielle Richards

Masters Theses, 2020-current

The purpose of the present study was to understand the effects of varying levels of polyphenols and fiber on postprandial C-peptide and insulin levels after consumption of a high fat, high sugar meal (HFHSM) in prediabetic individuals. All subjects were diagnosed as pre-diabetic within 3 months of the start date of the study by a medical professional or were screened as meeting one of the criteria for prediabetes by researchers within the James Madison Human Performance Lab by a HbA1c (5.7-6.4%), fasting glucose (100-126 mg/dL), or an oral glucose tolerance test (OGTT; 140-199 mg/dL). After an overnight fast, five females …

Morphological Characterization, Seed Production, And Oil Content Of Several Lemongrass (Cymbopogon Citratus (D.C.) Stapf.) Line, Adi Setiadi, Cheppy Syukur, Idam Holid, Lindiana

Jurnal Kultivasi

Cymbopogon citratus, commonly known as lemongrass, is a perennial herb widely cultivated for its culinary, medicinal, and aromatic industries. This research investigates the morphological characterization and potential yield of different lemongrass lines. The study involved the collection of diverse lemongrass genotypes from various geographic regions in Indonesia. The research was conducted using a randomized block design with three replications. Morphological character observations encompass both quantitative and qualitative characters of plants. Morphological characteristics such as plant height, leaf length and width, stem diameter, and number of tillers were measured to assess the variations among the genotypes. The results revealed considerable variability …

Evaluating The Client Base And Housing Outcomes Of A Community Based Organization Serving Unhoused Adults, Emi Caprio

Doctoral Dissertations

There is a well-documented, bidirectional relationship between mental health and housing instability. When coupled with the complex historical, societal, and political factors contributing to houselessness, the result is a unique set of mental health needs within this community. Despite this, there is a low rate of mental health service utilization and a dearth of research on how to tailor services to meet the needs of unhoused individuals. Additionally, first-hand perspectives are often omitted, as this population is seen as “hard to reach”. The goal of this two-phase mixed-methods program evaluation was to better understand the demographic and mental health profiles …

Strategies For Addressing Substance Abuse And Gambling Among Youth, Kevin T. Wolff

Publications and Research

This keynote address opens with a description of recent trends in substance use and gambling among youth, sharing insights from relevant research. I highlight that while some global trends indicate a decline in adolescent substance use, other areas, especially during the COVID-19 pandemic, have seen increases. I emphasize the importance of comprehensive prevention strategies, such as school-based, community-based, and family-based programs, and effective treatment approaches like behavioral interventions and integrated mental health services.

On the topic of youth gambling, I highlight the rising normalization and accessibility of gambling, particularly through the internet. I describe specific challenges in regions like South …

Managing Equine Metabolic Syndrome, Abigail Meldrum, Karl Hoopes

All Current Publications

Equine metabolic syndrome (EMS) is a relatively new disease that we are still learning about. There are many things to investigate when dealing with a new disease: causes, predispositions, symptoms, secondary issues, treatments, and prevention. Because changing the animal's feed regimen is currently the most effective and well-known way to manage EMS, this fact sheet focuses primarily on how diet can impact affected horses. As a newer syndrome, it is vital to learn as much as possible about it to understand, treat, and prevent this disease.

Integrated Modeling Of Nature’S Role In Human Well-Being: A Research Agenda, Rebecca Chaplin-Kramer, Stephen Polasky, Rob Alkemade, Neil D. Burgess, William W.L. Cheung, Ingo Fetzer, Mike Harfoot, Thomas W. Hertel, Samantha L.L. Hill, Justin Andrew Johnson, Jan H. Janse, Patrick José V. Jeetze, Hyejin Kim, Jan J. Kuiper, Eric Lonsdorf, David Leclère, Mark Mulligan, Garry D. Peterson, Alexander Popp, Stephanie Roe, Aafke M. Schipper, Tord Snäll, Arnout Van Soesbergen, Aline C. Soterroni, Elke Stehfest, Detlef P. Van Vuuren, Piero Visconti, Lan Wang-Erlandsson, Geoff Wells, Henrique M. Pereira

Department of Agricultural Economics Faculty Publications

Integrated assessment models that incorporate biodiversity and ecosystem services could be an important tool for improving our understanding of interconnected social-economic-ecological systems, and for analyzing how policy alternatives can shift future trajectories towards more sustainable development. Despite recent scientific and technological advances, key gaps remain in the scientific community’s ability to deliver information to decision-makers at the pace and scale needed to address sustainability challenges. We identify five research frontiers for integrated social-economic-ecological modeling (primarily focused on terrestrial systems) to

incorporate biodiversity and ecosystem services: 1) downscaling impacts of direct and indirect drivers on eco- systems; 2) incorporating feedbacks in …

Virtual Vortex, Yiling Jiang

Theses

This project examines the pervasive negative impacts of social media through the lens of 3D abstract motion in Virtual Vortex. While social media offers unparalleled convenience and connectivity, it also brings significant, often hidden, adverse effects on psychosocial health, personal privacy, and relationships. These consequences, although intangible, have profound implications that necessitate deeper scrutiny. In Virtual Vortex, I translate these abstract issues into concrete visuals, using 3D animation to make the invisible visible. By employing Cinema 4D (C4D) dynamics and mograph, I create a narrative where a yellow ball represents individuals, and various forms of social media icons symbolize the …

Plastic Abundance And Degradation In The Anaerobic Digestion Of Food Waste, Abbey Whitney

Theses

Food waste (FW) is a pervasive issue across the supply chain, with an estimated 30-40% of the food supply left unsold or uneaten annually (ReFED, 2022). In response, in 2015 the U.S. set a goal to halve FW by 2030 (U.S. EPA, 2020f). Valorization, the process of recovering value from FW, has become a key strategy, with anaerobic digestion (AD) playing a pivotal role. AD transforms organic waste into biogas and digestate, a potential soil amendment. However, plastic contamination in the organic waste stream poses a significant challenge. During digestion and storage, plastic debris can break down into microplastics (MP), …

Layered Naba2m3q3(Q2) (M = Cu Or Ag; Q = S Or Se) Chalcogenides And Local Ordering In Their Mixed-Anion Compositions, Ayat Tassanov, Huiju Lee, Yi Xia, James M. Hodges

Mechanical and Materials Engineering Faculty Publications and Presentations

Three new NaBa2M3Q3(Q2) (M = Ag or Cu; Q = S or Se) chalcogenides were prepared by using solid-state methods and structurally characterized by using single-crystal X-ray diffraction. NaBa2Ag3Se3(Se2) and NaBa2Cu3Se3(Se2) crystallize in monoclinic space group C2/m and have a two-dimensional structure composed of edge-sharing MSe4/4 tetrahedra separated by Na+ and Ba2+ cations, along with (Se2)2– dimers at the center of the spacings between [M3Se3]3– slabs. NaBa2Ag3S3(S2) adopts a related structure with space group C2/m but has additional, crystallographically distinct Ag atoms in the [Ag3S3]3– layer that are linearly coordinated. NaBa2Ag3Se3(Se2) and NaBa2Ag3S3(S2) have indirect band gaps measured to be …

Clathrin Light Chains Negatively Regulate Plant Immunity By Hijacking The Autophagy Pathway, Hu-Jiao Lan, Jie Ran, Wen-Xu Wang, Lei Zhang, Ni-Ni Wu, Ya-Ting Zhao, Min-Jun Huang, Min Ni, Fen Liu, Ninghui Cheng, Paul A Nakata, Jianwei Pan, Steven A Whitham, Barbara J Baker, Jian-Zhong Liu

Faculty, Staff and Students Publications

The crosstalk between clathrin-mediated endocytosis (CME) and the autophagy pathway has been reported in mammals; however, the interconnection of CME with autophagy has not been established in plants. Here, we report that the Arabidopsis CLATHRIN LIGHT CHAIN (CLC) subunit 2 and 3 double mutant, clc2-1 clc3-1, phenocopies Arabidopsis AUTOPHAGY-RELATED GENE (ATG) mutants in both autoimmunity and nutrient sensitivity. Accordingly, the autophagy pathway is significantly compromised in the clc2-1 clc3-1 mutant. Interestingly, multiple assays demonstrate that CLC2 directly interacts with ATG8h/ATG8i in a domain-specific manner. As expected, both GFP-ATG8h/GFP-ATG8i and CLC2-GFP are subjected to autophagic degradation, and degradation of GFP-ATG8h is …

A Social Media Game To Increase Physical Activity Among Older Adult Women: Protocol Of A Randomized Controlled Trial To Evaluate Challenge, Michael C Robertson, Maria Chang Swartz, Karen M Basen-Engquist, Yisheng Li, Kristofer Jennings, Debbe Thompson, Tom Baranowski, Elena Volpi, Elizabeth J Lyons

Faculty, Staff and Student Publications

BACKGROUND: Older adult women often do not engage in sufficient physical activity (PA) and can encounter biological changes that exacerbate the negative effects of inadequate activity. Wearable activity monitors can facilitate PA initiation, but evidence of sustained behavior change is lacking. Supplementing wearable technologies with intervention content that evokes enjoyment, interest, meaning, and personal values associated with PA may support long term adherence. In this paper, we present the protocol of an NIA-funded study designed to evaluate the efficacy of CHALLENGE for increasing step count and motivation for PA in insufficiently active older women (Challenges for Healthy Aging: Leveraging Limits …

How Is Diagnostic Uncertainty Communicated And Managed In Real World Primary Care Settings?, Jessica Russell, Laura Boswell, Athena Ip, Jenny Harris, Hardeep Singh, Ashley N D Meyer, Traber D Giardina, Afsana Bhuiya, Katriina L Whitaker, Georgia B Black

Faculty, Staff and Students Publications

Background: Managing diagnostic uncertainty is a major challenge in primary care due to factors such as the absence of definitive tests, variable symptom presentations and disease evolution. Maintaining patient trust during a period of investigative uncertainty, whilst minimising scope for diagnostic error is a challenge. Mismanagement can lead to diagnostic errors, treatment delays, and suboptimal patient outcomes.

Objective: Our aim was to explore how UK primary care physicians (GPs) address and communicate diagnostic uncertainty in practice.

Design: This qualitative study used video and audio-recordings. Verbatim transcripts were coded with a modified, validated tool to capture GPs' actions and communication in …

Mif/Nr3c2 Axis Regulates Glucose Metabolism Reprogramming In Pancreatic Cancer Through Mapk-Erk And Ap-1 Pathways, Shouhui Yang, Wei Tang, Azadeh Azizian, Jochen Gaedcke, Yuuki Ohara, Helen Cawley, Nader Hanna, Michael Ghadimi, Trisha Lal, Subrata Sen, Chad J Creighton, Jianjun Gao, Nagireddy Putluri, Stefan Ambs, Perwez Hussain

Faculty, Staff and Student Publications

Inflammation and aberrant cellular metabolism are widely recognized as hallmarks of cancer. In pancreatic ductal adenocarcinoma (PDAC), inflammatory signaling and metabolic reprogramming are tightly interwoven, playing pivotal roles in the pathogenesis and progression of the disease. However, the regulatory functions of inflammatory mediators in metabolic reprogramming in pancreatic cancer have not been fully explored. Earlier, we demonstrated that pro-inflammatory mediator macrophage migration inhibitory factor (MIF) enhances disease progression by inhibiting its downstream transcriptional factor nuclear receptor subfamily 3 group C member 2 (NR3C2). Here, we provide evidence that MIF and NR3C2 interactively regulate metabolic reprogramming, resulting in MIF-induced cancer growth …

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2023 Bpsou Subdrain Data Summary Report (Dated May 1, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Silver Bow Creek Conservation Area (Sbcca) Technical Specifications 60 Percent Submittal (Dated April 24, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Analysis Of Water Usage And Greenhouse Gas Emissions As Transition Fuel From Coal To Natural Gas In San Juan County, New Mexico, Tahereh Kookhaei

Civil Engineering ETDs

Abstract

Coal is a major contributor to various environmental issues, making the transition to alternative energy sources essential for reducing environmental impacts and combating climate change. San Juan County in New Mexico has historically depended on coal-fired power plants for producing electricity. However, due to environmental and economic pressures, there is a move to reassess energy strategies. This study explores the transition from coal to natural gas (NG) in San Juan County, with a focus on assessing changes in water usage and emissions (CO₂, NO_x, and SO₂) at the Four Corners (coal-fired) and Afton …

Therapeutic Importance Of Exercise In Neuroplasticity In Adults With Neurological Pathology: Systematic Review, Sara Valverde Cardoso, Sofia Rita Fernandes, Maria Teresa Tomás

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 1105-1119, 2024. Neuroplasticity is an essential mechanism by which the nervous system shapes and adapts according to functional requirements. Evidence suggests that physical exercise induces a cascade of cellular processes that favours brain plasticity. The Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin closely linked to neuroplasticity that can be increased due to exercise. To verify the effects of therapeutic exercise on neuroplasticity and/or peripheral BDNF levels in neurological conditions in adults, such as stroke, Parkinson’s and Alzheimer’s diseases and mild cognitive impairment and address its clinical relevance in the treatment of neurological dysfunctions. …