Digital Commons Network^™

Yoga As A Didactic Tool For Musculoskeletal Anatomy For First Year Medical Students, Jennnifer Brueckner-Collins, Scott P. Stuckey

Journal of Wellness

Introduction: Medical education requires students to adjust their study habits. Active learning has been shown to enhance understanding, especially regarding anatomy. Wellness has become increasingly emphasized for medical professionals; thus, it is important for medical students to develop wellness habits to mitigate burnout. Yoga is commonly practiced with a focus on wellness and flow of movements. Yoga as an educational and wellness tool integrated into medical gross anatomy is a worthwhile pursuit. This study describes a series of anatomy-based yoga videos designed to meld wellness activities with musculoskeletal anatomy review for preclinical medical students.

Approach: Six novel yoga …

Harnessing The Power Of Longitudinal Medical Imaging For Eye Disease Prognosis Using Transformer-Based Sequence Modeling, Gregory Holste, Mingquan Lin, Ruiwen Zhou, Fei Wang, Lei Liu, Qi Yan, Sarah H Van Tassel, Kyle Kovacs, Emily Y Chew, Zhiyong Lu, Zhangyang Wang, Yifan Peng

2020-Current year OA Pubs

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of acquisition, neglecting the common clinical setting of longitudinal imaging. For slow, progressive eye diseases like age-related macular degeneration (AMD) and primary open-angle glaucoma (POAG), patients undergo repeated imaging over time to track disease progression and forecasting the future risk of developing a disease is critical to properly plan treatment. Our proposed Longitudinal Transformer for Survival Analysis (LTSA) enables dynamic disease prognosis from longitudinal medical imaging, modeling the time to …

Expanding Treatment Options For Patients With Her2+ Metastatic Breast Cancer With Margetuximab Plus Chemotherapy: A Case Report Series, Reshma Mahtani, Natasha Harpalani

All Publications

Background: Human epidermal growth factor receptor 2 protein (HER2)-positive (+) metastatic breast cancer (MBC) is an aggressive disease and patients often undergo multiple lines of therapy following HER2 targeted therapies. The most recent National Comprehensive Cancer Network (NCCN) guidelines recommend margetuximab plus chemotherapy as fourth-line or later therapy for HER2+/hormone receptor (HR) + or negative (-) MBC. The aim of this case series is to provide information regarding margetuximab utilization in clinical practice as later-line therapy in women with HER2+ MBC.

Case summaries: Margetuximab plus chemotherapy was used as fourth- or later-line treatment in patients who had received multiple HER2-targeted …

Investigating The Potential Of Mdivi-1 In Mitigating The Harmful Effects Of Oxidized Low-Density Lipoprotein On Monocyte Functions And The Impact Of Oxldl On Monocyte Senescence Markers, Negin Mosalmanzadeh

Electronic Theses and Dissertations Archive

Cardiovascular diseases, particularly atherosclerosis, pose significant health risks due to their association with endothelial dysfunction and chronic inflammation. Oxidized low-density lipoprotein (OxLDL) plays a pivotal role in atherosclerosis by inducing foam cell formation and promoting inflammatory responses in monocytes. This study investigates the impact of OxLDL on monocyte functions, specifically focusing on metabolic changes, inflammatory responses, and cellular senescence. Additionally, we explore the potential of Mdivi-1, a mitochondrial division inhibitor, in mitigating the detrimental effects of OxLDL. Human monocytes were treated with OxLDL, resulting in increased glycolytic activity, elevated expression of pro-inflammatory cytokines (IL-1β and CXCL8), and significant foam cell …

Germline Genetic Determinates Of Cancer And Pre-Malignant Conditions, Jie Liu

Arts & Sciences Graduate Student Theses and Dissertations

Cancer is a genetic disease stemming from a combination of inherited and acquired mutations. In my thesis, we sought to characterize how germline genetic variation affects acquired clonal expansions in normal tissues and its progression to malignancy. In Chapter 2, we studied the impact of germline genetic variation on clonal hematopoiesis (CH) in 731,835 individuals. We identified 22 novel CH predisposition genes, most of which predispose to CH driven by specific mutational events. CH predisposition genes contribute to unique somatic landscapes reflecting the influence of germline genetic backdrop on gene-specific CH fitness. Correspondingly, somatic-germline interactions influence the risk of CH …

What Is The Economic Benefit Of Annual Covid-19 Vaccination From The Adult Individual Perspective?, Sarah M Bartsch, Kelly J O'Shea, Colleen Weatherwax, Ulrich Strych, Kavya Velmurugan, Danielle C John, Maria Elena Bottazzi, Mustafa Hussein, Marie F Martinez, Kevin L Chin, Allan Ciciriello, Jessie Heneghan, Alexis Dibbs, Sheryl A Scannell, Peter J Hotez, Bruce Y Lee

Center for Medical Ethics and Health Policy Staff Publications

Background: With coronavirus disease 2019 (COVID-19) vaccination no longer mandated by many businesses/organizations, it is now up to individuals to decide whether to get any new boosters/updated vaccines going forward.

Methods: We developed a Markov model representing the potential clinical/economic outcomes from an individual perspective in the United States of getting versus not getting an annual COVID-19 vaccine.

Results: For an 18-49 year old, getting vaccinated at its current price ($60) can save the individual on average $30-$603 if the individual is uninsured and $4-$437 if the individual has private insurance, as long as the starting vaccine efficacy against severe …

Neuromodulatory Co-Expression In Cardiac Vagal Motor Neurons Of The Dorsal Motor Nucleus Of The Vagus, Eden Hornung, Shaina Robbins, Ankita Srivastava, Sirisha Achanta, Jin Chen, Zixi Jack Cheng, James Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Vagal innervation is well known to be crucial to the maintenance of cardiac health, and to protect and recover the heart from injury. Only recently has this role been shown to depend on the activity of the underappreciated dorsal motor nucleus of the vagus (DMV). By combining neural tracing, transcriptomics, and anatomical mapping in male and female Sprague-Dawley rats, we characterize cardiac-specific neuronal phenotypes in the DMV. We find that the DMV cardiac-projecting neurons differentially express pituitary adenylate cyclase-activating polypeptide (PACAP), cocaine- and amphetamine-regulated transcript (CART), and synucleins, as well as evidence that they participate in neuromodulatory co-expression involving catecholamines. …

The Experience Of Homelessness And Its Effects On Gut Eubiosis, Kamerin Villagomez

University Honors Theses

Microorganisms which populate the human gastrointestinal tract (GIT) have a profound effect on overall human health. The relationship between host health and eubiosis, or balance, of the GIT microbiome is symbiotic and can have reciprocal relationships with quality of sleep, quality of diet, stress and mental health, and the experience of pain. These specific aspects of health are unique in populations experiencing homelessness due to the multi-dimensional and complex nature of their lived experience. Very few studies explore populations experiencing homelessness, with even fewer investigating the intersection between this population and the human GIT microbiome. It is important to do …

The Role Of Brown Adipose Tissue In Branched-Chain Amino Acid Clearance In People, Yasser G Abdelhafez, Guobao Wang, Siqi Li, Vanessa Pellegrinelli, Abhijit J Chaudhari, Anthony Ramirez, Fatma Sen, Antonio Vidal-Puig, Labros S Sidossis, Samuel Klein, Ramsey D Badawi, Maria Chondronikola

2020-Current year OA Pubs

Brown adipose tissue (BAT) in rodents appears to be an important tissue for the clearance of plasma branched-chain amino acids (BCAAs) contributing to improved metabolic health. However, the role of human BAT in plasma BCAA clearance is poorly understood. Here, we evaluate patients with prostate cancer who underwent positron emission tomography-computed tomography imaging after an injection of

Inhalational Drug Devices: Revisiting The Linchpin Of Asthma Management, Damini Saxena, Neveda Murugesan, Uyioghosa D Evbayiro, Marina K Ngassa, Muhammad Adrish

Faculty, Staff and Students Publications

Asthma remains a prevalent condition among all age groups globally. First-line treatment requires the delivery of medications into the distal respiratory tract via inhalers. Using appropriate inhaler techniques is a significant challenge in achieving disease control. A variety of inhalers are available for treating asthma, and selecting the appropriate inhaler type for any given patient is crucial to achieving and maintaining symptomatic control. This review will discuss the anatomy and physiology behind drug delivery via inhalers, the types of inhalers currently available for use, nebulizers, and future directions in the delivery of inhaled medications for asthma.

Pre-Existing Immunocompromising Conditions And Outcomes Of Acute Covid-19 Patients Admitted For Pediatric Intensive Care, Courtney M Rowan, Brenna Labere, Cameron C Young, Laura D Zambrano, Margaret M Newhams, Suden Kucukak, Elizabeth R Mcnamara, Elizabeth H Mack, Julie C Fitzgerald, Katherine Irby, Aline B Maddux, Jennifer E Schuster, Michele Kong, Heda Dapul, Stephanie P Schwartz, Melania M Bembea, Laura L Loftis, Amanda R Kolmar, Christopher J Babbitt, Ryan A Nofziger, Mark W Hall, Shira J Gertz, Natalie Z Cvijanovich, Matt S Zinter, Natasha B Halasa, Tamara T Bradford, Gwenn E Mclaughlin, Aalok R Singh, Charlotte V Hobbs, Kari Wellnitz, Mary A Staat, Bria M Coates, Hillary R Crandall, Mia Maamari, Kevin M Havlin, Adam J Schwarz, Christopher L Carroll, Emily R Levy, Kristin L Moffitt, Angela P Campbell, Adrienne G Randolph, Janet Chou

Faculty, Staff and Students Publications

BACKGROUND: We aimed to determine if pre-existing immunocompromising conditions (ICCs) were associated with the presentation or outcome of patients with acute coronavirus disease 2019 (COVID-19) admitted for pediatric intensive care.

METHODS: Fifty-five hospitals in 30 US states reported cases through the Overcoming COVID-19 public health surveillance registry. Patients(PICU) or high-acuity unit for acute COVID-19 were included.

RESULTS: Of 1274 patients, 105 (8.2%) had an ICC, including 33 (31.4%) hematologic malignancies, 24 (22.9%) primary immunodeficiencies and disorders of hematopoietic cells, 19 (18.1%) nonmalignant organ failure with solid-organ transplantation, 16 (15.2%) solid tumors, and 13 (12.4%) autoimmune disorders. Patients with ICCs were …

Patient And Family Contributions To Improve The Diagnostic Process Through The Ourdx Electronic Health Record Tool: A Mixed Method Analysis, Sigall K Bell, Kendall Harcourt, Joe Dong, Catherine Desroches, Nicholas J Hart, Stephen K Liu, Long Ngo, Eric J Thomas, Fabienne C Bourgeois

Faculty, Staff and Student Publications

Background: Accurate and timely diagnosis relies on sharing perspectives among team members and avoiding information asymmetries. Patients/Families hold unique diagnostic process (DxP) information, including knowledge of diagnostic safety blindspots-information that patients/families know, but may be invisible to clinicians. To improve information sharing, we co-developed with patients/families an online tool called 'Our Diagnosis (OurDX)'. We aimed to characterise patient/family contributions in OurDX and how they differed between individuals with and without diagnostic concerns.

Method: We implemented OurDX in two academic organisations serving patients/families living with chronic conditions in three subspecialty clinics and one primary care clinic. Prior to each visit, patients/families …

Tirzepatide Protects Against Hepatic Oxidative Stress In High-Fat Induced Obesity In Male Rats, Ashraf Jameel Alathary, Zahraa Jawad Kadhim

Maaen Journal for Medical Sciences

Background

Obesity is a prevalent health issue that affects people of all ages at a high rate. Tirzepatide (TZP) is a hypoglycemic medication that acts as a dual antagonist for both the GIP-1 and GIP receptors. Previous reports have shown that TZP treatment demonstrated substantial weight reduction as well as lipid-modulating effects in obese and overweight individuals.

Objective

The aim from this study is to examine the potential protective effect of TZP on oxidative stress status and HFD induced obesity in male rats.

Methods

This research employed a total of 28 adult male Sprague-Dawley rats. Normal control group involved seven …

The Relationships Between Upper And Lower Extremity Muscle Strength, Rate Of Force Development, And Fatigue In Adults, Matthew Langford, Kyle J. Hackney, Sarah Andrew, Joshua Batesole, Maren Berntson, Kennedy Black, Tyler Hoang, Lukus Klawitter, William J. Kraemer, Ryan Mcgrath

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1155-1166, 2024. Electronic handgrip dynamometry allows for multiple muscle function aspects to be feasibly measured, yet their relationship with lower extremity muscle function is unknown. We sought to determine the relationships between upper and lower extremity mechanical isometric muscle strength, rate of force development (RFD), and endurance by limb dominance in resistance trained adults. The analytic sample included 30 adults aged 32.1 ± 13.5 years. An electronic handgrip dynamometer ascertained upper extremity strength capacity, RFD, and endurance. Lower extremity strength, RFD, and endurance were collected with the isometric feature on an isokinetic knee dynamometer. …

Do Surrogate Markers Of Cardiorespiratory Fitness Predict Individual Changes In Vo2peak? A Randomized Controlled Trial, John R.M. Renwick, Nicholas Preobrazenski, Michael Del Giudice, Brendon J. Gurd

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1134-1154, 2024. The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO_2peak. Surrogate markers of CRF were time to fatigue on treadmill test (TTF), time trial performance (3kTT), resting heart rate (RHR), submaximal heart rate (SubmaxHR), and submaximal ratings of perceived exertion (SubmaxRPE). Twenty-five participants were randomized into a high-intensity interval training (HIIT: n = 14) group or non-exercise control group (CTL: n = 11). Training consisted of four weeks of high-intensity interval …

Mindfulness And Perceived Stress Among English Language Students In Uzbekistan, Laurie A. Wolfe, Rakhmatullo Akhmedov

The Interactive Journal of Global Leadership and Learning

The current study investigated the effective of mindfulness training versus study skills training on perceived stress among Uzbek English language students. The researchers conducted a quasi-experimental study using a convenience sample of sixty 2^nd year students studying English as a foreign language at a large public university in Tashkent, Uzbekistan. One group of students (n = 30) received mindfulness training while the other group served as an active control group (n = 30) and received study skills training. Both groups received 20-minute training in their English classes, four days a week, for 4-weeks. All participants completed pre- …

Examining Parental Engagement In Early Intervention, Part C Special Education, Through The Parents’ Perception, Zach Selnes

The Interactive Journal of Global Leadership and Learning

This study, employing a qualitative research approach within an interpretivist paradigm, aimed to explore the diverse experiences of parental engagement among 25 families with children receiving early intervention (i.e., Part C special education services) in a rural southeast MN educational district. While there has been a plethora of research on parental engagement, that research is often limited to how teachers perceive parental engagement or interactions in school activities or curriculum (Ansari & Markowitz, 2021; Gross et al., 2020; Hackworth et al., 2018). When parents actively, and intentionally, engage with their child outside of intervention services, it significantly enhances the child's …

Exploring School Of Education Faculty Emotion, Attitudes, And Experiences Related To Student Mental Health, Jesse Mossholder

The Interactive Journal of Global Leadership and Learning

Student mental health concerns among adolescents and young adults are continuing to rise (Reis et al., 2023, Ashoorian, 2018; Burns et al., 2017; Davies et al., 2016). The purpose of the present study was to explore teacher preparation faculty perceptions of student mental health concerns. The author adapted Stine Ekorne’s (2016) Perceived Competence Scale to score each participant's perceived competence, responsibility, and emotions related to addressing student mental health concerns. The 27-item Qualtrics questionnaire was distributed to faculty and academic staff in the School of Education at a midwestern public university. Participants were recruited through email. Participants included tenured and …

Teachers’ Perceptions Of Public Policy And Their Impact On Teacher Retention, Carl Bryan

The Interactive Journal of Global Leadership and Learning

Fewer issues have received more attention by education researchers than understanding the global teacher shortage, especially in public schools. Concurrent with this issue is the concern that the rate of teacher hires is insufficient to meet the needs of an increasingly diverse body of students. Further, while the research on job satisfaction, specifically in understanding their impact on teacher retention, is multifaceted, causal data underlying these approaches have been limited. This research gains significance in light of policymakers’ increasing calls for restructuring the way schools do business to effectively meet the diverse needs of students, often in spite of already-limited …

Drawing The Line: How The Lower Courts Must Adapt To Using Non-Retroactive Changes In Law When Granting Sentence Reductions In Light Of Amended Guidelines, Sophia M. Liechty

Helms School of Government Undergraduate Law Review

The United States Courts of Appeals have been divided on whether non-retroactive amendments can be used to reduce an inmate’s sentence under United States Sentencing Guidelines § 1B1.13 in light of the First Step Act. Before the United States Supreme Court’s intervention, the Sentencing Commission acted to amend the First Step Act, clarifying that a nonretroactive change in law may be used as an extraordinary and compelling reason for sentence reduction when the sentence is “unusually long.” The lower federal courts have begun to implement this amendment when granting sentence reductions. However, with these amended guidelines, ambiguity remains regarding how …

Slaughtering Slaughter-House: An Assessment Of 14th Amendment Privileges Or Immunities Jurisprudence, Caleb Webb

Helms School of Government Undergraduate Law Review

In 1872, the Supreme Court decided the Slaughter-House Cases, which applied a narrow interpretation of the Privileges or Immunities Clause of the 14th Amendment that effectually erased the clause from the Constitution. Following Slaughter-House, the Supreme Court compensated by utilizing elastic interpretations of the Due Process Clause in its substantive due process jurisprudence to cover the rights that would have otherwise been protected by the Privileges or Immunities Clause. In more recent years, the Court has heard arguments favoring alternative interpretations of the Privileges or Immunities Clause but has yet to evaluate them thoroughly. By applying the Court’s previously articulated …

Intraluminal Tracheal Stenting In Dog With Tracheal Collapse : A Case Report, Ratiporn Tantisak, Siriluck Luckanahasaporn, Ardong Atiptamvaree, Tamolwan Anyamaneecharoen, Kamonchanok Lamsaman, Suphat Soeratanapant, Poondej Charunmethee

The Thai Journal of Veterinary Medicine

A 12-year-old female neutered dog was referring to the pet hospital for the chief complaint of syncopic episodes 3 times/day. The dog had history of severe goose-honking non-productive cough and tachypnea. The dog got worsen despites medical management was consist of antibiotic, mucolytic, bronchodilator, glucocorticoids and nebulization. The dog was not response to medication then develop to apnea due to obstructive breathing. The radiographs diagnosis from private clinic was redundant trachea with narrowing intrathoracic trachea. The surgical treatment was considered. The tracheobronchoscopy was confirmed Tracheal collapse at mid cervical to cranial thoracic part. Stenting was a treatment options in life-threatening …

Application Of Metoclopramide As Gastroprokinetic In Koi Carp (Cyprinus Carpio) With Positive Buoyancy Disorders, Pornpawit Tanpichai, Thanaboon Katechaimongkol, Patharapol Piamsomboon, Thanida Haetrakul

The Thai Journal of Veterinary Medicine

A two-year-old Koi carp or fancy carp (Cyprinus carpio) with a symptom of recurrent positive buoyancy was admitted to the Veterinary Medical Aquatic Animal Research Center of Excellence (VMARCE), Faculty of Veterinary Science, Chulalongkorn University. Radiographic examination with positive contrast media revealed gas accumulation in the gastrointestinal tract without obstruction; subsequently, idiopathic intestinal pseudo-obstruction was suspected. The anti-flatulence drug simethicone was administered, but the fish did not respond to the treatment. Therefore, metoclopramide, as the medical trial at a dosage of 0.5 mg/kg, was intramuscularly injected once daily for four consecutive days. The fish convalesced with neutral buoyancy …

Cardiac Biomarkers For Monitoring Canine Heartworm Disease: A Comparative Study Of N-Terminal Pro B Type Natriuretic Peptide And Cardiac Troponin I Levels, Sariya Asawakarn, Kittipong Tachampa, Piyanan Taweethavonsawat

The Thai Journal of Veterinary Medicine

Canine heartworm disease is a global mosquito-borne parasitic illness that affects dogs. The main species of filarids responsible for this disease is Dirofilaria immitis. This article specifically explores the use of cardiac biomarkers, such as N-terminal pro B type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI), for diagnosing and monitoring canine heartworm disease. These biomarkers can indicate myocardial injury and heart failure, particularly in chronic infections. The study compares the levels of NT-proBNP and cTnI in dogs with heartworm disease, both clinically diagnosed cases and those without symptoms. The results reveal that cTnI is elevated in both cases, …

Quantitative Assessment Of Preoperative And Postoperative Brachycephalic Airway Obstruction Syndrome Surgery Using Clinical Grading Questionnaires And 6-Minute Walk Test In French Bulldogs, Tamolwan Anyamaneecharoen, Krishaporn Kradangnga, Saikaew Sutayatram, Pasakorn Brikshavana, Sumit Durongphongtorn

The Thai Journal of Veterinary Medicine

Brachycephalic airway obstructive syndrome (BAOS) is an anatomical abnormality of the upper airway commonly found in brachycephalic breeds, leading to clinical signs and physical capacity impairment. The degree of stenotic nares was reported to be related to BAOS severity in French bulldogs. This study aimed to compare clinical signs and physical capacity in French bulldogs before and after BAOS surgery using modified Roedler questionnaires and a 6-minute walk test (6-MWT). Twenty-seven French bulldogs were enrolled in this study (non-BAOS control (n=7), non-severe stenotic nares BAOS dogs (n=8), and severe stenotic nares BAOS dogs (n=12). BAOS surgery included staphylectomy using bipolar …

Conventional Vs Three-Dimensional Computed Tomography For Measurement Of Tibial Tuberosity To Trochlear Groove Distance In Small Breed Dogs With And Without Medial Patellar Luxation, Radka S. Garnoeva

The Thai Journal of Veterinary Medicine

The operative technique for medial patellar luxation (MPL) is dependent on the degree of accompanying bone deformities. The most frequent abnormalities: the shallow trochlear groove and tibial tuberosity medialisation are corrected surgically with trochleoplasty and tibial tuberosity transposition, respectively. The aim of the present study was to determine the distance between the tibial tuberosity and the trochlear groove (TT-TG) on two-dimensional axial computed tomography (CT) scans and three-dimensional multiplanar reconstruction images from 21 stifles from healthy dogs and 15 stifles from dogs with grade 2 MPL and to compare the performance of both methods. Two axial CT scans of the …

Seroprevalence Of Lawsonia Intracellularis Antibodies Among Large-Scale Swine Farming Systems In Thailand, Thanh Che Nguyen, Chairani Ridha Maghfira, Nathaya Young, Kanokwan Samatiwat, Chaiyan Kaewpaluk, Apisak Laothanakit, Pawarisa Mungprasittichai, Roongroje Thanawongnuwech, Yaowalak Panyasing

The Thai Journal of Veterinary Medicine

Gastrointestinal infectious diseases caused by bacteria have been a major problem in the swine industry, including Thailand. Porcine proliferative enteropathy (PPE), also known as porcine ileitis, is an enteric infectious disease caused by Lawsonia intracellularis – an obligate intracellular bacterium. PPE has been an economic threat to the global pork production system due to various types of diarrheas. Serological diagnosis can be applied to the seroprevalence of pathogen-antibodies and the timing of L. intracellularis infection when introduced to the herd. This present study showed the current serological status and the seroprevalence of antibodies against L. intracellularis in large-scale Thai swine …

Investigation Of P27 Tumor Suppressor Gene (Cdkn1b) Polymorphisms In Dogs With Malignant Mammary Tumors, Gizem Kırmızıoğlu, Iraz Akış

The Thai Journal of Veterinary Medicine

Mammary tumors are the most common neoplasm in dogs, with a high mortality rate. The development of canine mammary tumors (CMT) is multifactorial, but different incidence rates between breeds suggest the effects of genetic risk factors. Many CMT-associated candidate genes were reported, mainly involved in cell cycle control. This study aims to investigate p27 tumor suppressor gene polymorphisms in dogs with mammary tumors and analyze the association between variations and CMTs. For this purpose, case and control groups were formed from 22 dogs diagnosed with malignant mammary tumors and 10 dogs with healthy mammary glands. The whole canine p27 gene …

Preventive Effects Of Quercetin On The Leaky Gut By Suppression Of Il-1beta-Induced Transcription Factors Involved In An Inflammatory Pathway In Colonic Epithelial Cells, Wannaporn Chayalak, Sumpun Thammacharoen, Chatsri Deachapunya, Sutthasinee Poonyachoti

The Thai Journal of Veterinary Medicine

Flavonol quercetin (Q), found in vegetables and fruits, demonstrates the most potent anti-inflammatory effect. The preventive effect and cellular mechanisms of Q (Q1, Q10, and Q100 µM) on IL-1β induced leaky gut via the signaling molecules of inflammatory pathway, NF-κB p65-iκB/or p38/ERK1/2/MLCK/phospho(p)-MLC were investigated in Caco-2 cells. The cytotoxic effect of Q was initially determined by MTT assay. Transepithelial electrical resistance (TER) and apical-to-basolateral fluorescein isothiocyanate-labeled dextran (FD-4) flux were used to determine paracellular permeability. The protein expression of signaling molecules was examined by Western blot analysis, and their target MLCK mRNA expression was determined using real-time PCR. All Q …

Impacts Of Species, Gender Disparities, And Covid-19 Lockdowns On Population Control: Insights From 337,590 Dogs And Cats In Bangkok Metropolitan Administration (Bma), Thailand (2009-2023), Shanaporn Leelakajornkit, Natchanon Dumniem, Permsak Wataganara, Siwa Maison, Suppawiwat Ponglowhapan

The Thai Journal of Veterinary Medicine

Surgical sterilization stands as a key solution to address the overpopulation of dogs and cats, with numerous influencing factors impacting the success of population control efforts, including species, gender, and financial conditions. The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, in 2020 has significantly altered human life and impacted pet animals. Lockdown restrictions were implemented in various countries, including Thailand, affecting the cumulative data of neutered animals, which was subsequently analyzed in this study. There were 337,590 dogs and cats from 2009 to 2023, and the data were systematically categorized by years, species, and gender. …