Digital Commons Network^™

Development And Testing Of Small-Scale Flash Dryer For Maize Bran, Eden Ngowi

Tanzania Journal of Engineering and Technology (TJET)

Sun drying is the most common technique used to dry various food products due to its economic convenience. However, it is not effective owing to its unreliable nature leading to microbial deterioration and aflatoxin contamination of food. In Tanzania, about 1.3 million tonnes of maize bran are at risk of deterioration annually due to improper drying. The aim of this study was to design, fabricate and test an efficient small-scale flash dryer for maize bran. Using principles of material and energy balance, a small-scale flash dryer with a throughput of 500 kg of dry product per hour was designed resulting …

‘‘Domicilelessness’’ And Livelihoods In Urban Areas: Case Of Maasai In Dar Es Salaam, Tanzania, Ombeni Swai

Tanzania Journal of Engineering and Technology (TJET)

The study aimed at demonstrating Maasai migration into Dar es Salaam urban areas and their challenges in accessing accommodation. Methodologically, the study deployed secondary data analysis following a descriptive research design. Furthermore, this study was conducted through both qualitative and quantitative research approaches. The study was conducted from 2018 to 2022 of which a random sample of 100 (N=100) was targeted. The data was analyzed using the Statistical Package for Social Sciences (SPSS Version 16). Findings: The Maasai means of accommodation are divided into four main categories: completed houses (6%), under-construction sites (39%), halfway constructed and abandoned structures (31%), and …

Exploring The Transformation Of Sustainable Collective Spaces: A Study From Mlalakuwa Informal Settlement, Jacob Lutta

Tanzania Journal of Engineering and Technology (TJET)

A major challenge in collective space transformation is addressing the complexity of informal urbanisation in developing countries. Using a case study approach, this paper examines the concerns related to a particular informal settlement's sustainable collective space transformation. One of the key findings is that the absence of formal rules and regulations in the development of informal settlements in combination with land-grabbing leads to the absence of open spaces that could be used collectively. It is observed that sustainability in urban development is another body of critical thought that integrates several streams of current urban elements and embodies various conceptions of …

Investigations Of Cell Tower Antennas Parameters On Reduction Of Radio Frequency Radiation Levels From Radio Base Stations, Florence U. Rashidi

Tanzania Journal of Engineering and Technology (TJET)

The widespread deployment of mobile cellular base stations in populated areas has raised public health concerns due to increased exposure to radio frequency (RF) radiation emissions. Exposure to high levels of RF radiation can have potential thermal and non-thermal biological effects. Optimizing the configuration of cell tower antenna parameters is crucial for mitigating these radiation levels. This study therefore aims at systematically investigating the influence of different cell tower antenna parameters on reducing the RF radiation levels from mobile base stations. Field measurements were conducted at two cell sites shared by multiple mobile operators. Electric field strengths were measured at …

Lean Manufacturing Practices In Tanzania: Exploring Awareness, Training And Capital Investment, Francis D. Sinkamba

Tanzania Journal of Engineering and Technology (TJET)

With the growing competition among industries in the world, manufacturing industries are now forced to adopt the Lean Manufacturing philosophy to improve their competitive abilities. The adoption of the philosophy is very low in developing countries such as Tanzania, as is demonstrated with 1% of publications and the lack of knowledge and capital for Lean Manufacturing implementation causes this. Furthermore, the contribution of the sector to the Gross Domestic Product in Tanzania is low and stands at 8.4%. The study wants to bridge the gap in training, capital and awareness of Lean Manufacturing in Tanzania. Survey and purposive sampling techniques …

A Comparison Between Unit-Based Education And Centralized Education Among Staff Nurses, Marilyn J. Campbell

Dissertations

Educating staff nurses is pivotal in the evolving healthcare environment. Two staff development models used in the healthcare setting are unit-based and centralized. Unit-based education is a staff development model that places educators on individual units. These educators direct the educational development of staff nurses on their assigned units. Centralized education meets generalized learning needs and provides nursing departments with scheduled education sessions or impromptu meetings regarding changes to policies and procedures. In addition, centralized educators are assigned to address the learning needs of the nurses on several units with universal orientation (Cummings & McCaskey, 1992), coordinate and implement intravenous …

Analysis Of Serum Exosome Metabolites Identifies Potential Biomarkers For Human Hepatocellular Carcinoma, Tingting Zhao, Yan Liang, Xiaolan Zhen, Hong Wang, Li Song, Didi Xing, Hui Li

Faculty, Staff and Student Publications

Currently, the clinical cure rate for primary liver cancer remains low. Effective screening and early diagnosis of hepatocellular carcinoma (HCC) remain clinical challenges. Exosomes are intimately associated with tumor development and their contents have the potential to serve as highly sensitive tumor-specific markers. A comprehensive untargeted metabolomics study was conducted using exosome samples extracted from the serum of 48 subjects (36 HCC patients and 12 healthy controls) via a commercial kit. An ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) strategy was used to identify the metabolic compounds. A total of 18 differential metabolites were identified using the non-targeted metabolomics approach of UPLC-QTOF-MS/MS. …

Evaluation Of Business-Driven Reference Architecture For Big Data Analytics Implementation By Public Sector Organizations In Resource-Constrained Setting: A Case Study Of Uganda, Matendo Didas

Tanzania Journal of Engineering and Technology (TJET)

Big Data Analytics (BDA) is a new area at the nexus of agenda, public sector organizations, and government business. It may satisfy the growing need for trustworthy, cost-effective services in the public sector for better, more informed decision-making processes. BDA has been proposed on the planning schedules of several public sector organizations and the government. Therefore, from the previous work, using Uganda as a case study, specifically the Uganda Bureau of Statistics (UBOS), Ministry of Health (MoH), and Ministry of Education and Sports (MoES), this study aims to evaluate a designed Business-Driven Reference Architecture for Big Data Analytics Implementation (BRABDAI) …

Assessment Of The Factors Affecting The National Ict Broadband Backbone (Nictbb) Systems Restoration Time, Victoria Mahabi

Tanzania Journal of Engineering and Technology (TJET)

This study investigates the factors affecting the prolonged system restoration time when national ICT broadband backbone (NICTBB) services are affected by breakdown incidents. NICTBB is the government-owned backbone infrastructure constructed nationally by the Republic of Tanzania to increase the usage of ICT for equitable and sustainable socio-economic development and accelerate poverty reduction. This study utilised a mixture of exploratory and descriptive study approaches. The sample size determination was executed using purposing and simple random sampling, thus involving 289 respondents. The data reliability test was undertaken. It was followed by factor analysis, analysis of variances (ANOVA), linear regression analysis, and confirmed …

Modeling The Influence Of Internal Factors On Vehicular Mobility Performance, Aziz Mdimi

Tanzania Journal of Engineering and Technology (TJET)

Traffic mobility is significantly influenced by road conditions and the internal factors governing vehicular performance. Internal factors play a crucial role in vehicular mobility, influencing vehicles operate and performance. While existing vehicular mobility models primarily address external factors, external factors such as governor, engine, gear train and differential unit remain underexplored. This study formulates a comprehensive model to address this gap, focusing on the internal components that affect vehicular mobility. The proposed model employs both analytical and numerical methods to derive transfer functions for these subsystems using Matrix Laboratory (MATLAB), aiming to capture the dynamic behavior of vehicles under various …

New Programs Help Meet Need For Public Health Professionals, Edwin Smith

University of Mississippi News

OXFORD, Miss. – The University of Mississippi is addressing the growing need for public health professionals in the state through two degree programs in its new Department of Public Health in the university's School of Applied Sciences.

Comparative Treatment Of Homeless Persons With An Infectious Disease In The Us Emergency Department Setting: A Retrospective Approach, Jessica Barnes, Larry Segars, Jason A. Wasserman, Patrick Karabon, Tracey A.H. Taylor

Faculty and Staff Publications

Background: Research has long documented the increased emergency department usage by persons who are homeless compared with their housed counterparts, as well as an increased prevalence of infectious diseases. However, there is a gap in knowledge regarding the comparative treatment that persons who are homeless receive. This study seeks to describe this potential difference in treatment, including diagnostic services tested, procedures performed and medications prescribed.

Methods: This study used a retrospective, cohort study design to analyse data from the 2007-2010 United States National Hospital Ambulatory Medical Care Survey database, specifically looking at the emergency department subset. Complex sample logistic regression …

3d Mr Fingerprinting For Dynamic Contrast-Enhanced Imaging Of Whole Mouse Brain, Yuran Zhu, Yuning Gu, Walter Zhao, Jiahao Lu, Junqing Zhu, Christina J. Macaskill, Andrew Dupuis, Mark A. Griswold, Dan Ma, Chris A. Flask, Xin Yu

Faculty Scholarship

Purpose: Quantitative MRI enables direct quantification of contrast agent concentrations in contrast-enhanced scans. However, the lengthy scan times required by conventional methods are inadequate for tracking contrast agent transport dynamically in mouse brain. We developed a 3D MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping across the whole mouse brain with 4.3-min temporal resolution. Method: We designed a 3D MRF sequence with variable acquisition segment lengths and magnetization preparations on a 9.4T preclinical MRI scanner. Model-based reconstruction approaches were employed to improve the accuracy and speed of MRF acquisition. The method's accuracy for T1 and T2 measurements was …

Teacher Implementation Profiles: A Response To Top-Down Mandate Of Movement Integration, Zack Beddoes, Jeanne Barcelona, Darla Castelli

International Journal of Physical Activity and Health

This study examined teacher implementation practices to meet a state mandate requiring 135 minutes of student physical activity (PA) weekly. Teachers were required to implement a video-based movement integration (MI) program. Using an embedded mixed-methods design, provider characteristics of 42 teachers and the organizational capacity of six schools were developed from interviews, surveys, observations, and artifacts. Data analysis revealed three teacher profiles (a) Dynamic Experientialists, (b) Coachable Constructivists, and (c) Cautious Behaviorists, and three school profiles (a) Whole Child Approach, (b) Grade Level Champions, and (c) Back to Basics. Findings suggest that school, teacher, …

Development Of A New Individual Interest Questionnaire In Physical Education, Minting Zhang, Bo Shen, Jin Bo

International Journal of Physical Activity and Health

Recognizing the close interconnection between implicit-affective control and cognitive-rational aspects of individual interest, we designed this study to develop a new instrument - the Individual Interest Questionnaire in Physical Education (IIQ-PE). In study 1 (N=132), an exploratory factor analysis supported a model consisting of a single unified factor. In study 2 (N=117), Confirmatory Factor Analyses corroborated the construct validity of the IIQ-PE. Also, when examining multi-group invariance across the two study samples, no significant differences were found, suggesting that this factor structure held consistently. In study 3 (N=121), a path model further demonstrated that the individual interest significantly predicted learning …

Epigenome-Wide Association Study Of Prostate Cancer In African American Men Identified Differentially Methylated Genes, Anders Berglund, Kosj Yamoah, Steven A. Eschrich, Rana Falahat, James J. Mulé, Sungjune Kim, Jaime Matta, Julie Dutil, Gilberto Ruiz-Deya, Carmen Ortiz Sanchez, Liang Wang, Hyun Park, Hirendra N. Banerjee, Tamara Lotan, Kathryn Hughes Barry, Ryan M. Putney, Seung Joon Kim, Clement Gwede, Jacob K. Kresovich, Youngchul Kim, Hui Yi Lin, Jasreman Dhillon, Ratna Chakrabarti, Jong Y. Park

School of Public Health Faculty Publications

Introduction: Men with African ancestry have the highest incidence and mortality rates of prostate cancer (PCa) worldwide. Methods: This study aimed to identify differentially methylated genes between tumor vs. adjacent normal and aggressive vs. indolent PCa in 121 African American patients. Epigenome-wide DNA methylation patterns in tumor DNA were assessed using the human Illumina Methylation EPIC V1 array. Results: Around 5,139 differentially methylated CpG-sites (q < 0.01, lΔβl > 0.2) were identified when comparing normal vs. tumor, with an overall trend of hypermethylation in prostate tumors. Multiple representative differentially methylated regions (DMRs), including immune-related genes, such as CD40, Galectin3, OX40L, and STING, were detected …

August 20, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Socioeconomic Status, Physical Inactivity, And Bmi In Transitional Urban China: Contextualizing The Theory Of Fundamental Causes, Jun Xu, Fang Gong, Wei Zhao

International Journal of Physical Activity and Health

Drawing insights from the theory of fundamental causes of disease, this study examined the relationships between socioeconomic status (SES) and selected risk factors in transitional urban China. Specifically, under China’s distinct institutional and sociocultural environment, we examined how contextualized SES (i.e., party membership, hukou status, housing ownership, and subjective social status) and conventional SES indicators (i.e., education, income, and occupation) were associated with physical inactivity and body mass index (BMI). Utilizing the urban subsample of the 2017 Chinese General Social Survey (CGSS), we found that individuals with higher education, income, Communist Party membership, and urban hukou status had lower risks …

Engaging Vs. Non-Engaging Abutments: An In Vitro Study Evaluating Changes In Microgap And Screw Morphology, Fawaz M. Alzoubi, Mohammad Y. Sabti, Esra Alsarraf, Faris A. Alshahrani, Steven J. Sadowsky

Pacific Faculty Work

Background: The purpose of this study was to compare the microgap size between engaging (E) and non-engaging (NE) abutments and screw morphology changes between E and NE abutments using scanning electron microscopy (SEM) before and after cyclic loading (CL). Methods: Thirty-six implants were arranged into four groups as follows: Group 1, single units with E abutments; Group 2, single units with NE abutments; Group 3, three-unit fixed partial dentures with a hemi-engaging design; and Group 4, three-unit FPDs with two NE abutments. The microgap was evaluated using a stereomicroscope. SEM was used to qualitatively evaluate screw morphology. The specimens were …

Epcam-Targeted Betulinic Acid Analogue Nanotherapy Improves Therapeutic Efficacy And Induces Anti-Tumorigenic Immune Response In Colorectal Cancer Tumor Microenvironment, Debasmita Dutta, Ashique Al Hoque, Brahamacharry Paul, Jun Hyoung Park, Chinmay Chowdhury, Mohiuddin Quadir, Soumyabrata Banerjee, Arghadip Choudhury, Soumik Laha, Nayim Sepay, Priyanka Boro, Benny Abraham Kaipparettu, Biswajit Mukherjee

Faculty, Staff and Students Publications

Background: Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, its poor solubility and off-target activity have limited its utility in clinical trials. Additionally, the immune modulatory role of betulinic acid analogue in the tumor microenvironment (TME) is largely unknown. Here, we designed a potential nanotherapy for colorectal cancer (CRC) with a lead betulinic acid analogue, named as 2c, carrying a 1,2,3-triazole-moiety attached to BA through a linker, found more effective than BA for inhibiting CRC cell lines, and was chosen here for this investigation. Epithelial cell adhesion molecule (EpCAM) …

Structural Basis For Substrate Binding And Selection By Human Mitochondrial Rna Polymerase, Karl Herbine, Ashok Nayak, Dmitry Temiakov

Department of Biochemistry and Molecular Biology Faculty Papers

The mechanism by which RNAP selects cognate substrates and discriminates between deoxy and ribonucleotides is of fundamental importance to the fidelity of transcription. Here, we present cryo-EM structures of human mitochondrial transcription elongation complexes that reveal substrate ATP bound in Entry and Insertion Sites. In the Entry Site, the substrate binds along the O helix of the fingers domain of mtRNAP but does not interact with the templating DNA base. Interactions between RNAP and the triphosphate moiety of the NTP in the Entry Site ensure discrimination against nucleosides and their diphosphate and monophosphate derivatives but not against non-cognate rNTPs and …

Effects Of Attending A Workshop To Deepen Participants' Understanding Of The Roy Adaptation Model, Hidaka Tsuyako, Ide Nobu, Obama Satsuki, Ishimoto Sachiko, Fortin Eric

General Submissions: Presentations (Oral and Poster)

This study aims to explore the educational effects of attending workshops through focus group interviews (FGIs) with continuing workshop participants.

Appropriateness Of Imaging For Low-Risk Prostate Cancer-Real World Data From The Pennsylvania Urologic Regional Collaboration (Purc), Raidizon Mercedes, Dennis Head, Elizabeth Zook, Eric Eidelman, Jeffrey Tomaszewski, Serge Ginzburg, Robert Uzzo, Marc Smaldone, John Danella, Thomas Guzzo, Daniel Lee, Laurence Belkoff, Jeffrey Walker, Adam Reese, Mihir Shah, Bruce Jacobs, Jay Raman

Einstein Health Papers

Imaging for prostate cancer defines the extent of disease. Guidelines recommend against imaging low-risk prostate cancer patients with a computed tomography (CT) scan or bone scan due to the low probability of metastasis. We reviewed imaging performed for men diagnosed with low-risk prostate cancer across the Pennsylvania Urologic Regional Collaborative (PURC), a physician-led data sharing and quality improvement collaborative. The data of 10 practices were queried regarding the imaging performed in men diagnosed with prostate cancer from 2015 to 2022. The cohort included 13,122 patients with 3502 (27%) low-risk, 2364 (18%) favorable intermediate-risk, 3585 (27%) unfavorable intermediate-risk, and 3671 (28%) …

Investigation Of Heavy Metal Composition And Associated Health Risks From Selected Groundwater Wells In Temeke, Dar-Es-Salaam, Justin M. Jeremiah

Tanzania Journal of Engineering and Technology (TJET)

Water quality continues to be the challenge to residents in Dar es Salaam due to various anthropogenic activities in the city. This study was conducted to assess groundwater quality by determining concentrations of heavy metals. Both probability and Nonprobability sampling techniques were used to collect samples from 40 groundwater wells in 24 wards of Temeke municipal and analysed using Microwave Plasma Atomic Emission Spectrometer (Agilent 4210 MP-AES) at the Geochemistry Laboratory of the University of Dar es Salaam. Results indicated varying heavy metal concentrations ranging from 0.71 ± 0.08 to 6.64 ± 0.21 mg/l for As, 0.02 ± 0.01 to …

Bp1003 Decreases Stat3 Expression And Its Pro-Tumorigenic Functions In Solid Tumors And The Tumor Microenvironment, Maria Gagliardi, Rhonda Kean, Bingbing Dai, Jithesh Augustine, Michael Roberts, Jason Fleming, D. Craig Hooper, Ana Ashizawa

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Overexpression and aberrant activation of signal transducer and activator of transcription 3 (STAT3) contribute to tumorigenesis, drug resistance, and tumor-immune evasion, making it a potential cancer therapeutic target. BP1003 is a neutral liposome incorporated with a nuclease-resistant P-ethoxy antisense oligodeoxynucleotide (ASO) targeting the STAT3 mRNA. Its unique design enhances BP1003 stability, cellular uptake, and target affinity. BP1003 efficiently reduces STAT3 expression and enhances the sensitivity of breast cancer cells (HER2⁺, triple negative) and ovarian cancer cells (late stage, invasive ovarian cancer) to paclitaxel and 5-fluorouracil (5-FU) in both 2D and 3D cell cultures. Similarly, ex vivo and in …

Hydroxyurea In The Sickle Cell Disease Modern Era, Chazmyn Riley, Walter K. Kraft, Robin Miller

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

INTRODUCTION: Sickle cell disease is an inherited disorder characterized by hemoglobin S polymerization leading to vaso-occlusion and hemolytic anemia. These result in a variety of pathological events, causing both acute and chronic complications. Millions around the world are affected by sickle cell disease with predominance in sub-Saharan Africa. Hydroxyurea was the first drug approved for use in sickle cell disease to reduce the occurrence of painful crises and blood transfusions in patients with frequent, moderate to severe painful crises.

AREAS COVERED: With the development of new therapeutics, the role of hydroxyurea is evolving. This narrative review aims to provide clinical …

Microvascular Autologous Breast Reconstruction With The Lateral Thigh Perforator Flap, Stefania M.H. Tuinder, Joep A.F. Van Rooij, Robert J. Allen

School of Medicine Faculty Publications

The lateral thigh perforator flap is an excellent alternative to the deep inferior epigastric artery perforator (DIEP) flap for patients with absolute or relative contraindications for a DIEP flap and adequate volume at the lateral thigh. Preoperative physical examination, preoperative markings, and radiological perforator mapping are essential for adequate surgical preparation. The flap is based on septocutaneous perforators of the lateral circumflex femoral artery, located in the posterior septum between the tensor fascia latae and the gluteus medius muscle. Being relatively stiff, septocutaneous perforators are sensitive to kinking and compression, which is important to keep in mind during flap inset. …

Beyond #Blacklivesmatter Through An Understanding Of Intersectionality And Ethical Leadership: A Critical Autoethnography Of A Black Female Graduate Student Living With Multiple Hidden Dis/Abilities, Shariese Katrell

Theses and Dissertations

There can be numerous questions to be asked concerning the perspective of a Black female graduate student at a predominately White institution who lives with multiple hidden dis/Abilities (Gillborn, 2015). This critical autoethnography can help discover and uncover new issues and establish transformational changes that could expand knowledge and research surrounding the critical analysis of intersectionality and Disability Studies and Critical Race Theory from an/abled feminist approach. Transformative politics can be identified in this study, which examines socialism and the systematic structures and power within academia at the graduate level (Trevino et al., 2008). The issues of Black disability feminism, …

Identifying The Interactors Of Otud6b-2 That Are Important For Its Function On C-Myc, Farah Albatsh

Master's Theses

The complexity of molecular signaling pathways, particularly in cancer research, has made the proto-oncogene c-Myc a key focus due to its role as a master regulator of cellular processes such as growth, division, and apoptosis. Dysregulation of c-Myc is linked to various cancers, making it a highly sought therapeutic target despite challenges in directly inhibiting its function. Recent efforts have shifted towards indirect targeting methods, including BET inhibitors, cyclin-dependent kinase inhibitors, and siRNA formulations. A novel approach using PROTACs and the investigation of c-Myc-specific deubiquitinases (DUBs) has shown potential, particularly the emerging player OTUD6B-2. This study aims to identify and …

Challenges Of Maintaining Sobriety For Adults In Recovery Returning To College, Rosalina Johns

Walden Dissertations and Doctoral Studies

Alcohol abuse is a prevalent problem among college students, with negative consequences on academic performance, social interactions, and well-being. The purpose of this qualitative phenomenological study was to explore the lived experiences and challenges of sobriety for recovering adults returning to college. Sociocultural theory was used to gain insights into participants’ experiences including resilience, risk and protective factors, and stress. Data were collected from semi structured interviews with three college students who were recovering adults. The data included participants’ responses regarding intervention or mediation techniques that eased their barriers and challenges during their academic journey. The findings revealed core themes …