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Editorial: Covid And Autism 2023: Lessons Learnt And Future Directions For Research, Georgina Pérez Liz, Michaela Dubay, Cecilia Montiel-Nava Aug 2024

Editorial: Covid And Autism 2023: Lessons Learnt And Future Directions For Research, Georgina Pérez Liz, Michaela Dubay, Cecilia Montiel-Nava

Psychological Science Faculty Publications

No abstract provided.

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A 72-Year-Old Man With Acute Lung Injury And Anti-Melanoma Differentiation-Associated Gene 5 Antibody: A Case Report, Irakli Lemonjava, Jose Manuel Martinez Manzano, Sahar Sultan, Rekha Bhat, Corrado Minimo, Zurab Azmaiparashvili, Sadia Benzaquen Aug 2024

A 72-Year-Old Man With Acute Lung Injury And Anti-Melanoma Differentiation-Associated Gene 5 Antibody: A Case Report, Irakli Lemonjava, Jose Manuel Martinez Manzano, Sahar Sultan, Rekha Bhat, Corrado Minimo, Zurab Azmaiparashvili, Sadia Benzaquen

Einstein Health Papers

Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA-5 Ab) is associated with amyopathic dermatomyositis (DM). These patients are particularly at high-risk for developing acute and rapidly progressive interstitial lung disease (ILD). Given the lack of muscle-related symptoms, along with its sudden onset and rapid clinical progression, the diagnosis of anti-MDA-5 Ab + ILD represents a challenge for clinicians. Even after the diagnosis is established, prognosis remains dismal owing to a hyperinflammatory state, mimicking cytokine storm, commonly refractory to potent immunosuppressive therapy. Hence, we present an elderly African American man who developed acute and rapidly progressive ILD in the setting of positive anti-MDA5 …

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Role Of Kindlin 2 In Prostate Cancer, Katarzyna Bialkowska, Lamyae El Khalki, Priyanka Rana, Wei Wang, Daniel Lindner, Yvonne Parker, Lucia Languino, Dario Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward Plow Aug 2024

Role Of Kindlin 2 In Prostate Cancer, Katarzyna Bialkowska, Lamyae El Khalki, Priyanka Rana, Wei Wang, Daniel Lindner, Yvonne Parker, Lucia Languino, Dario Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward Plow

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Kindlin-2 is a cytoskeletal adapter protein that is present in many different cell types. By virtue of its interaction with multiple binding partners, Kindlin-2 intercalates into numerous signaling pathways and cytoskeletal nodes. A specific interaction of Kindlin-2 that is of paramount importance in many cellular responses is its direct binding to the cytoplasmic tails of integrins, an interaction that controls many of the adhesive, migratory and signaling responses mediated by members of the integrin family of cell-surface heterodimers. Kindlin-2 is highly expressed in many cancers and is particularly prominent in prostate cancer cells. CRISPR/cas9 was used as a primary approach …

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Welcoming The Classes Of 2027 And 2028 At Nyls’S 2024 Orientation, Jennifer Bancamper Aug 2024

Welcoming The Classes Of 2027 And 2028 At Nyls’S 2024 Orientation, Jennifer Bancamper

NYLS Community News

No abstract provided.

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Implementing A Dayroom For Acute Care Patients With Dementia, Darcy Copeland, Karla Call Aug 2024

Implementing A Dayroom For Acute Care Patients With Dementia, Darcy Copeland, Karla Call

General Submissions: Presentations (Oral and Poster)

The purpose of this EBP (Evidence Based Practice) project was to reduce restraint use and length of stay among patients with dementia admitted to an acute care unit.

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Donor Types And Outcomes Of Transplantation In Myelofibrosis: A Cibmtr Study, Tania Jain, Noel Estrada-Merly, M Queralt Salas, Soyoung Kim, Jakob Devos, Min Chen, Xi Fang, Rajat Kumar, Marcio Andrade-Campos, Hany Elmariah, Vaibhav Agrawal, Mahmoud Aljurf, Ulrike Bacher, Talha Badar, Sherif M Badawy, Karen Ballen, Amer Beitinjaneh, Vijaya Raj Bhatt, Christopher Bredeson, Zachariah Defilipp, Bhagirathbhai Dholaria, Nosha Farhadfar, Shatha Farhan, Arpita P Gandhi, Siddhartha Ganguly, Usama Gergis, Michael R Grunwald, Nada Hamad, Betty K Hamilton, Yoshihiro Inamoto, Madiha Iqbal, Omer Jamy, Mark Juckett, Mohamed A Kharfan-Dabaja, Maxwell M Krem, Deepesh P Lad, Jane Liesveld, Monzr M Al Malki, Adriana K Malone, Hemant S Murthy, Guillermo Ortí, Sagar S Patel, Attaphol Pawarode, Miguel-Angel Perales, Marjolein Van Der Poel, Olle Ringden, David A Rizzieri, Alicia Rovó, Bipin N Savani, Mary Lynn Savoie, Sachiko Seo, Melhem Solh, Celalettin Ustun, Leo F Verdonck, John R Wingard, Baldeep Wirk, Nelli Bejanyan, Richard J Jones, Taiga Nishihori, Betul Oran, Ryotaro Nakamura, Bart Scott, Wael Saber, Vikas Gupta Aug 2024

Donor Types And Outcomes Of Transplantation In Myelofibrosis: A Cibmtr Study, Tania Jain, Noel Estrada-Merly, M Queralt Salas, Soyoung Kim, Jakob Devos, Min Chen, Xi Fang, Rajat Kumar, Marcio Andrade-Campos, Hany Elmariah, Vaibhav Agrawal, Mahmoud Aljurf, Ulrike Bacher, Talha Badar, Sherif M Badawy, Karen Ballen, Amer Beitinjaneh, Vijaya Raj Bhatt, Christopher Bredeson, Zachariah Defilipp, Bhagirathbhai Dholaria, Nosha Farhadfar, Shatha Farhan, Arpita P Gandhi, Siddhartha Ganguly, Usama Gergis, Michael R Grunwald, Nada Hamad, Betty K Hamilton, Yoshihiro Inamoto, Madiha Iqbal, Omer Jamy, Mark Juckett, Mohamed A Kharfan-Dabaja, Maxwell M Krem, Deepesh P Lad, Jane Liesveld, Monzr M Al Malki, Adriana K Malone, Hemant S Murthy, Guillermo Ortí, Sagar S Patel, Attaphol Pawarode, Miguel-Angel Perales, Marjolein Van Der Poel, Olle Ringden, David A Rizzieri, Alicia Rovó, Bipin N Savani, Mary Lynn Savoie, Sachiko Seo, Melhem Solh, Celalettin Ustun, Leo F Verdonck, John R Wingard, Baldeep Wirk, Nelli Bejanyan, Richard J Jones, Taiga Nishihori, Betul Oran, Ryotaro Nakamura, Bart Scott, Wael Saber, Vikas Gupta

Department of Medical Oncology Faculty Papers

We evaluate the impact of donor types on outcomes of hematopoietic cell transplantation (HCT) in myelofibrosis, using the Center for International Blood and Marrow Transplant Research registry data for HCTs done between 2013 and 2019. In all 1597 patients, the use of haploidentical donors increased from 3% in 2013 to 19% in 2019. In study-eligible 1032 patients who received peripheral blood grafts for chronic-phase myelofibrosis, 38% of recipients of haploidentical HCT were non-White/Caucasian. Matched sibling donor (MSD)-HCTs were associated with superior overall survival (OS) in the first 3 months (haploidentical hazard ratio [HR], 5.80 [95% confidence interval (CI), 2.52-13.35]; matched …

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Student Affairs Minutes 08/27/2024, Student Affairs Committee Aug 2024

Student Affairs Minutes 08/27/2024, Student Affairs Committee

Student Affairs Committee

No abstract provided.

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Whole Genome And Reverse Protein Phase Array Landscapes Of Patient Derived Osteosarcoma Xenograft Models, Chia-Chin Wu, Licai Huang, Zhongting Zhang, Zhenlin Ju, Xingzhi Song, E Anders Kolb, Wendong Zhang, Jonathan Gill, Min Ha, Malcolm A Smith, Peter Houghton, Christopher L Morton, Raushan Kurmasheva, John Maris, Yael Mosse, Yiling Lu, Richard Gorlick, P Andrew Futreal, Hannah C Beird Aug 2024

Whole Genome And Reverse Protein Phase Array Landscapes Of Patient Derived Osteosarcoma Xenograft Models, Chia-Chin Wu, Licai Huang, Zhongting Zhang, Zhenlin Ju, Xingzhi Song, E Anders Kolb, Wendong Zhang, Jonathan Gill, Min Ha, Malcolm A Smith, Peter Houghton, Christopher L Morton, Raushan Kurmasheva, John Maris, Yael Mosse, Yiling Lu, Richard Gorlick, P Andrew Futreal, Hannah C Beird

Faculty, Staff and Student Publications

Osteosarcoma is the most common primary bone malignancy in children and young adults, and it has few treatment options. As a result, there has been little improvement in survival outcomes in the past few decades. The need for models to test novel therapies is especially great in this disease since it is both rare and does not respond to most therapies. To address this, an NCI-funded consortium has characterized and utilized a panel of patient-derived xenograft models of osteosarcoma for drug testing. The exomes, transcriptomes, and copy number landscapes of these models have been presented previously. This study now adds …

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Evaluating The Impact Of Laboratory-Based Eligibility Criteria By Race/Ethnicity In First-Line Clinical Trials Of Dlbcl, Arushi Khurana, Raphael Mwangi, Loretta J Nastoupil, Patrick M Reagan, Umar Farooq, Jason T Romancik, Timothy J Mcdonnell, Shaun M Riska, Lzidore S Lossos, Brad S Kahl, Peter Martin, Thomas E Witzig, James R Cerhan, Christopher R Flowers, Grzegorz S Nowakowski, Matthew J Maurer Aug 2024

Evaluating The Impact Of Laboratory-Based Eligibility Criteria By Race/Ethnicity In First-Line Clinical Trials Of Dlbcl, Arushi Khurana, Raphael Mwangi, Loretta J Nastoupil, Patrick M Reagan, Umar Farooq, Jason T Romancik, Timothy J Mcdonnell, Shaun M Riska, Lzidore S Lossos, Brad S Kahl, Peter Martin, Thomas E Witzig, James R Cerhan, Christopher R Flowers, Grzegorz S Nowakowski, Matthew J Maurer

Faculty, Staff and Student Publications

Underrepresentation of racial and ethnic subgroups in cancer clinical trials remains a persistent challenge. Restrictive clinical trial eligibility criteria have been shown to exacerbate this problem. We previously identified that up to 24% of patients treated with standard immunochemotherapy would have been excluded from recent first-line trials in diffuse large B-cell lymphoma (DLBCL) based on 5 laboratory-based criteria. These ineligible patients had worse clinical outcomes and increased deaths related to lymphoma progression, suggesting the potential exclusion of patients who could have benefited most from the novel therapies being evaluated. Using data from the prospectively enrolled Lymphoma Epidemiology Outcomes cohort study, …

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Multicenter, Phase 1 Study Of Etavopivat (Ft-4202) Treatment For Up To 12 Weeks In Patients With Sickle Cell Disease, Santosh L Saraf, Robert Hagar, Modupe Idowu, Ifeyinwa Osunkwo, Kimberly Cruz, Frans A Kuypers, R Clark Brown, James Geib, Maria Ribadeneira, Patricia Schroeder, Eric Wu, Sanjeev Forsyth, Patrick F Kelly, Theodosia A Kalfa, Marilyn J Telen Aug 2024

Multicenter, Phase 1 Study Of Etavopivat (Ft-4202) Treatment For Up To 12 Weeks In Patients With Sickle Cell Disease, Santosh L Saraf, Robert Hagar, Modupe Idowu, Ifeyinwa Osunkwo, Kimberly Cruz, Frans A Kuypers, R Clark Brown, James Geib, Maria Ribadeneira, Patricia Schroeder, Eric Wu, Sanjeev Forsyth, Patrick F Kelly, Theodosia A Kalfa, Marilyn J Telen

Faculty, Staff and Student Publications

Etavopivat is an investigational, once daily, oral, selective erythrocyte pyruvate kinase (PKR) activator. A multicenter, randomized, placebo-controlled, double-blind, 3-part, phase 1 study was conducted to characterize the safety and clinical activity of etavopivat. Thirty-six patients with sickle cell disease (SCD) were enrolled into 4 cohorts: 1 single-dose, 2 multiple ascending doses, and 1 open-label (OL). In the OL cohort, 15 patients (median age 33.0 years [range, 17-55]) received 400 mg etavopivat once daily for 12 weeks; 14 patients completed treatment. Consistent with the mechanism of PKR activation, increases in adenosine triphosphate and decreases in 2,3-diphosphoglycerate were observed and sustained over …

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Instruments For Dual-Factor Mental Health Screening In Elementary Schools: Implications In Mental Health Classification, Mei-Ki Chan, Michael J. Furlong, Emmy Ruff Aug 2024

Instruments For Dual-Factor Mental Health Screening In Elementary Schools: Implications In Mental Health Classification, Mei-Ki Chan, Michael J. Furlong, Emmy Ruff

Psychology Faculty Publications

This research study holds practical significance for educators, school administrators, and mental health professionals. The study utilized structural equation modeling on two samples of elementary school students in grades three to five to create and validate condensed versions of the Social-Emotional Health Survey-Primary and the Me and My School questionnaire. These abbreviated scales exhibited strong internal validity and reliability across grade levels and genders, allowing for the assessment of wellness and distress among a diverse range of elementary school students. Furthermore, data from a longitudinal sample investigated dual-factor mental health profiles and their consistency over one year. Based on the …

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Neutralization Escape, Infectivity, And Membrane Fusion Of Jn1-Derived Sars-Cov-2 Slip, Flirt, And Kp2 Variants, Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Kai Xu, Shan-Lu Liu Aug 2024

Neutralization Escape, Infectivity, And Membrane Fusion Of Jn1-Derived Sars-Cov-2 Slip, Flirt, And Kp2 Variants, Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Kai Xu, Shan-Lu Liu

Faculty, Staff and Student Publications

We investigate JN.1-derived subvariants SLip, FLiRT, and KP.2 for neutralization by antibodies in vaccinated individuals, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients, or class III monoclonal antibody S309. Compared to JN.1, SLip, KP.2, and especially FLiRT exhibit increased resistance to bivalent-vaccinated and BA.2.86/JN.1-wave convalescent human sera. XBB.1.5 monovalent-vaccinated hamster sera robustly neutralize FLiRT and KP.2 but have reduced efficiency for SLip. All subvariants are resistant to S309 and show decreased infectivity, cell-cell fusion, and spike processing relative to JN.1. Modeling reveals that L455S and F456L in SLip reduce spike binding for ACE2, while R346T in FLiRT and KP.2 strengthens …

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Selective Androgen Receptor Modulators Leading To Liver Injury: A Case Report, Michael R. Demangone, Karam R. Abi Karam, Joshua Li Aug 2024

Selective Androgen Receptor Modulators Leading To Liver Injury: A Case Report, Michael R. Demangone, Karam R. Abi Karam, Joshua Li

Student Publications

Selective androgen receptor modulators (SARMs) have gained popularity for their alleged ability to selectively target androgen receptors, potentially offering muscle-building benefits with fewer side effects than traditional steroids. However, the safety profile of SARMs, including RAD-140, is not fully understood. This case report presents a 29-year-old male who developed liver injury after taking RAD-140. The patient experienced jaundice and elevated liver enzymes after three months of RAD-140 use. A liver ultrasound revealed hepatic steatosis and a hyperechoic lesion. Symptoms resolved after discontinuing RAD-140. Similar cases of liver injury associated with RAD-140 have been reported, highlighting the potential hepatotoxicity of this …

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Pipe Dream: Remyelination Therapy For Multiple Sclerosis, Benjamin Deneen Aug 2024

Pipe Dream: Remyelination Therapy For Multiple Sclerosis, Benjamin Deneen

Faculty, Staff and Students Publications

No abstract provided.

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Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project - July 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis Aug 2024

Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project - July 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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A Systematic Review On The Effectiveness Of Brain-Breaks® Video Programming On Academic Performance And Physical Activity Of School Children, Garry Kuan, Ming Kai Chin, Yee Cheng Kueh, Abdulwali Sabo, Magdalena Mo Ching Mok, Govindasamy Balasekaran, Yu Kai Chang, Christopher R. Edginton, Ian Culpan, Biljana Popeska, J. Larry Durstine Aug 2024

A Systematic Review On The Effectiveness Of Brain-Breaks® Video Programming On Academic Performance And Physical Activity Of School Children, Garry Kuan, Ming Kai Chin, Yee Cheng Kueh, Abdulwali Sabo, Magdalena Mo Ching Mok, Govindasamy Balasekaran, Yu Kai Chang, Christopher R. Edginton, Ian Culpan, Biljana Popeska, J. Larry Durstine

Faculty Publications

Purpose: This study aimed to complete a systematic review of the effect of the Brain Breaks® video program on academic performance and health-related outcomes among schoolchildren. Methods: A literature search was performed using Scopus, PubMed, ResearchGate, ScienceDirect, and Google Scholar databases to identify published manuscripts from December 2017 to December 2023. Dissertations, theses, monographs, and commentaries were excluded from this review. Results: A total of 15 studies were included in the review. Most studies applied quasi-experimental design and were conducted in Asia and Europe with children. Nine of these studies found that Brain Breaks® improved students' attitudes toward physical activity …

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Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program (Rmap) Brown’S Gulch Borrow Submittal #1 (Dated July 22, 2024), Molly Roby Aug 2024

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program (Rmap) Brown’S Gulch Borrow Submittal #1 (Dated July 22, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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Assessing The Relationship Between Psychological Readiness And Physical Performance In Secondary School Physical Education, Nicholas Cullen-Carroll Aug 2024

Assessing The Relationship Between Psychological Readiness And Physical Performance In Secondary School Physical Education, Nicholas Cullen-Carroll

Doctorate in Kinesiology

The purpose of this project was to analyze the relationship between a psychological preparedness survey and physical performance tests. Perceived preparedness is a valid measure for determining readiness to train, however, there is a lack of studies evaluating high school-aged students and the relationship these scales have with physical performance tests. 41 high school students were recruited and participated in a single session including a 6-point preparedness survey, an aerobic capacity test, and a power test. Demographic, perceptive, and performance data were recorded and analyzed. Pearson correlations were used to determine the relationship between the performance and preparedness variables. Significant …

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Kmt2c Restricts G-Csf-Driven Hsc Mobilization And Granulocyte Production In A Methyltransferase-Independent Manner, Helen C Wang, Ran Chen, Wei Yang, Yanan Li, Rohini Muthukumar, Riddhi M Patel, Emily B Casey, Elisabeth Denby, Jeffrey A Magee Aug 2024

Kmt2c Restricts G-Csf-Driven Hsc Mobilization And Granulocyte Production In A Methyltransferase-Independent Manner, Helen C Wang, Ran Chen, Wei Yang, Yanan Li, Rohini Muthukumar, Riddhi M Patel, Emily B Casey, Elisabeth Denby, Jeffrey A Magee

2020-Current year OA Pubs

Granulocyte colony-stimulating factor (G-CSF) is widely used to enhance myeloid recovery after chemotherapy and to mobilize hematopoietic stem cells (HSCs) for transplantation. Unfortunately, through the course of chemotherapy, cancer patients can acquire leukemogenic mutations that cause therapy-related myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). This raises the question of whether therapeutic G-CSF might potentiate therapy-related MDS/AML by disproportionately stimulating mutant HSCs and other myeloid progenitors. A common mutation in therapy-related MDS/AML involves chromosome 7 deletions that inactivate many tumor suppressor genes, including KMT2C. Here, we show that Kmt2c deletions hypersensitize murine HSCs and myeloid progenitors to G-CSF, as evidenced …

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Evaluating The Impact Of Laboratory-Based Eligibility Criteria By Race/Ethnicity In First-Line Clinical Trials Of Dlbcl, Arushi Khurana, Brad S Kahl, Et Al. Aug 2024

Evaluating The Impact Of Laboratory-Based Eligibility Criteria By Race/Ethnicity In First-Line Clinical Trials Of Dlbcl, Arushi Khurana, Brad S Kahl, Et Al.

2020-Current year OA Pubs

Underrepresentation of racial and ethnic subgroups in cancer clinical trials remains a persistent challenge. Restrictive clinical trial eligibility criteria have been shown to exacerbate this problem. We previously identified that up to 24% of patients treated with standard immunochemotherapy would have been excluded from recent first-line trials in diffuse large B-cell lymphoma (DLBCL) based on 5 laboratory-based criteria. These ineligible patients had worse clinical outcomes and increased deaths related to lymphoma progression, suggesting the potential exclusion of patients who could have benefited most from the novel therapies being evaluated. Using data from the prospectively enrolled Lymphoma Epidemiology Outcomes cohort study, …

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Baf155 Controls Hematopoietic Differentiation And Regeneration Through Chromatin Priming, Jun Wu, Changxu Fan, Ashraf Ul Kabir, Karen Krchma, Minseo Kim, Yoojung Kwon, Xiaoyun Xing, Ting Wang, Kyunghee Choi Aug 2024

Baf155 Controls Hematopoietic Differentiation And Regeneration Through Chromatin Priming, Jun Wu, Changxu Fan, Ashraf Ul Kabir, Karen Krchma, Minseo Kim, Yoojung Kwon, Xiaoyun Xing, Ting Wang, Kyunghee Choi

2020-Current year OA Pubs

Chromatin priming promotes cell-type-specific gene expression, lineage differentiation, and development. The mechanism of chromatin priming has not been fully understood. Here, we report that mouse hematopoietic stem and progenitor cells (HSPCs) lacking the Baf155 subunit of the BAF (BRG1/BRM-associated factor) chromatin remodeling complex produce a significantly reduced number of mature blood cells, leading to a failure of hematopoietic regeneration upon transplantation and 5-fluorouracil (5-FU) injury. Baf155-deficient HSPCs generate particularly fewer neutrophils, B cells, and CD8

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A Rad18-Ubc13-Palb2-Rnf168 Axis Mediates Replication Fork Recovery In Brca1-Deficient Cancer Cells, Emily Cybulla, Sierra Wallace, Alice Meroni, Jessica Jackson, Sumedha Agashe, Mithila Tennakoon, Mangsi Limbu, Annabel Quinet, Elena Lomonosova, Hollie Noia, Stephanie Tirman, Matthew Wood, Alessandro Vindigni, Et Al. Aug 2024

A Rad18-Ubc13-Palb2-Rnf168 Axis Mediates Replication Fork Recovery In Brca1-Deficient Cancer Cells, Emily Cybulla, Sierra Wallace, Alice Meroni, Jessica Jackson, Sumedha Agashe, Mithila Tennakoon, Mangsi Limbu, Annabel Quinet, Elena Lomonosova, Hollie Noia, Stephanie Tirman, Matthew Wood, Alessandro Vindigni, Et Al.

2020-Current year OA Pubs

BRCA1/2 proteins function in genome stability by promoting repair of double-stranded DNA breaks through homologous recombination and by protecting stalled replication forks from nucleolytic degradation. In BRCA1/2-deficient cancer cells, extensively degraded replication forks can be rescued through distinct fork recovery mechanisms that also promote cell survival. Here, we identified a novel pathway mediated by the E3 ubiquitin ligase RAD18, the E2-conjugating enzyme UBC13, the recombination factor PALB2, the E3 ubiquitin ligase RNF168 and PCNA ubiquitination that promotes fork recovery in BRCA1- but not BRCA2-deficient cells. We show that this pathway does not promote fork recovery by preventing replication fork reversal …

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Nonreciprocity In Chikv And Mayv Vaccine-Elicited Protection, Whitney C Weber, Takeshi F Andoh, Craig N Kreklywich, Zachary J Streblow, Michael Denton, Magdalene M Streblow, John M Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T Curiel, Nicole N Haese, Daniel N Streblow Aug 2024

Nonreciprocity In Chikv And Mayv Vaccine-Elicited Protection, Whitney C Weber, Takeshi F Andoh, Craig N Kreklywich, Zachary J Streblow, Michael Denton, Magdalene M Streblow, John M Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T Curiel, Nicole N Haese, Daniel N Streblow

2020-Current year OA Pubs

Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use. Mayaro virus (MAYV) is a related emerging alphavirus with epidemic potential with circulation overlap potential with CHIKV. We previously reported the ability of a non-replicating human adenovirus (AdV)-vectored vaccine expressing the MAYV structural polyprotein to protect against disease in mice following challenge with MAYV, CHIKV and UNAV. Herein, we evaluated mouse immunity and protective efficacy for an AdV-CHIKV full structural polyprotein vaccine in combination with heterologous AdV-MAYV prime/boost regimens versus vaccine coadministration. Heterologous prime/boost regimens skewed immunity toward …

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Dual Color Optogenetic Tool Enables Heart Arrest, Bradycardic, And Tachycardic Pacing In Drosophila Melanogaster, Elena Gracheva, Yuxuan Wang, Jiantao Zhu, Fei Wang, Abigail Matt, Matthew Fishman, Hongwu Liang, Chao Zhou Aug 2024

Dual Color Optogenetic Tool Enables Heart Arrest, Bradycardic, And Tachycardic Pacing In Drosophila Melanogaster, Elena Gracheva, Yuxuan Wang, Jiantao Zhu, Fei Wang, Abigail Matt, Matthew Fishman, Hongwu Liang, Chao Zhou

2020-Current year OA Pubs

In order to facilitate cardiovascular research to develop non-invasive optical heart pacing methods, we have generated a double-transgenic Drosophila melanogaster (fruit fly) model suitable for optogenetic pacing. We created a fly stock with both excitatory H134R-ChR2 and inhibitory eNpHR2.0 opsin transgenes. Opsins were expressed in the fly heart using the Hand-GAL4 driver. Here we describe Hand > H134R-ChR2; eNpHR2.0 model characterization including bi-directional heart control (activation and inhibition) upon illumination of light with distinct wavelengths. Optical control and real-time visualization of the heart function were achieved non-invasively using an integrated light stimulation and optical coherence microscopy (OCM) system. OCM produced high-speed …

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Sustainable Food Systems Education In Nutrition And Dietetics: An Appraisal Of The Tertiary Landscape In Multiple Countries, Jessica Wegener, Liza Barbour, Liesel Carlsson, Clare Pettinger, Tracy Everitt, Nanna Meyer Aug 2024

Sustainable Food Systems Education In Nutrition And Dietetics: An Appraisal Of The Tertiary Landscape In Multiple Countries, Jessica Wegener, Liza Barbour, Liesel Carlsson, Clare Pettinger, Tracy Everitt, Nanna Meyer

School of Health Professions

A content analysis of course descriptions from program websites was conducted between 2021and 2022. Courses were reviewed, analyzed, and evaluated using a novel sustainability metric.Despite a growing awareness of the gap between professional expectations and competence,there has been no comprehensive appraisal of sustainable food systems (SFS) education withindietetics and nutrition programs to date. Dietitians and nutritionists play important roles inpromoting sustainability yet many perceive themselves to be inadequately trained. This projectexplored how, and to what degree, SFS education is incorporated into accredited nutrition anddietetics programs in the United Kingdom, Australia, and Canada. SFS is integrated into theeducation environment of some, …

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Caregivers’ Experiences Supporting The Transition To Adulthood Of Adolescents With Acquired Intellectual Disability, Melinda Rose Jordan Aug 2024

Caregivers’ Experiences Supporting The Transition To Adulthood Of Adolescents With Acquired Intellectual Disability, Melinda Rose Jordan

Walden Dissertations and Doctoral Studies

Transitioning to adulthood can be challenging for adolescents with acquired intellectual disability (caused through an accident, brain injury, neglect, or health condition) and their caregivers. The purpose of this study was to examine lived experiences of caregivers who cared for adolescents with acquired intellectual disability during their transition into adulthood. This study used the phenomenological qualitative design guided by the social support theory. Three research questions were asked: what do caregivers of an adolescent with acquired intellectual disability experience as they support the adolescent’s transition to adulthood, how do caregivers of an adolescent with acquired intellectual disability experience social support …

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Experiences Of Queer Female Counselor Educators: An Intersectional Interpretive Phenomenological Analysis, Caryn Leonard-Wilde Aug 2024

Experiences Of Queer Female Counselor Educators: An Intersectional Interpretive Phenomenological Analysis, Caryn Leonard-Wilde

Walden Dissertations and Doctoral Studies

The Council for Accreditation of Counselor Education and Related Programs and the American Counseling Association require counseling programs (CPs) to recruit, employ, and retain diverse faculty. Queer sexual orientation and gender identity is considered an aspect of diversity with which counselors must gain competency and against which counselors should not discriminate yet little is known about queer female counselor educators (QFCEs) with intersecting minority identities. The purpose of this interpretive phenomenological analysis (IPA) with both hermeneutic and intersectionality theory frameworks was to explore the experiences and meaning making of QFCEs and to describe the impact of these experiences on QFCE’s …

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Aged-Out Foster Youths’ Exposure To Spiritual Foster Homes And Transition Into Adulthood, Dr. Valerie Elaine Sims Aug 2024

Aged-Out Foster Youths’ Exposure To Spiritual Foster Homes And Transition Into Adulthood, Dr. Valerie Elaine Sims

Walden Dissertations and Doctoral Studies

There are 438,000 children and youth in foster care in the United States; almost 46,000 are aged 16 or older, and over 20,000 “age out” of many child welfare services between ages 18 and 20 every year. This qualitative phenomenological study aimed to explore the lived experience of foster youth growing up in a spiritual foster home (incorporating religious belief, practice, higher power, Bible study, or youth groups) and aging out of the system through the lens of faith-based theory. This study had a sample size of eight participants, ages 18 to 25, who transitioned out of the foster care …

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Constructive Engagement Between Ecological Thoughts Of Karl Marx And Lao Zi, Hongyin Zhou, Yuqi Chen Aug 2024

Constructive Engagement Between Ecological Thoughts Of Karl Marx And Lao Zi, Hongyin Zhou, Yuqi Chen

Comparative Philosophy

The global ecological crisis has posed unprecedented survival challenges to human being. Consequently, ecological issues have naturally become central concerns in philosophy. From the methodological perspective of constructive engagement in comparative philosophy, we have chosen to compare the ecological thoughts of two thinkers—Karl Marx and Lao Zi (老子)—who are separated by vast spans of time and cultural tradition. We argue that Karl Marx holds a mild anthropocentric ecological view, while Lao Zi holds a transcendental ecological view. In addressing ecological issues, Lao Zi’s transcendental methodological guiding principles can provide negative methodological constraints for Karl …

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From Contemplation To Counseling: Exploring Philosophical Practice By Constructive-Engagement Strategy Of Comparative Philosophy, Xiaojun Ding, Chao Yang, Peter Harteloh, Feng Yu Aug 2024

From Contemplation To Counseling: Exploring Philosophical Practice By Constructive-Engagement Strategy Of Comparative Philosophy, Xiaojun Ding, Chao Yang, Peter Harteloh, Feng Yu

Comparative Philosophy

This paper applies Bo Mou’s Constructive-Engagement Strategy of Comparative Philosophy (CESCP) to explore philosophical practice as a novel paradigm that applies philosophy to everyday life. The study advocates for a transformative methodology that seeks truth through critical engagement, joint contributions, and diverse methodological tools, advancing the discipline towards a comprehensive world philosophy. Philosophical practice, characterized by its engagement with human experience and existential inquiries, integrates Eastern and Western philosophies to guide individuals in the art of living. It offers a philosophical alternative to psychological counseling, focusing on reasoning to address life’s challenges and ethical dilemmas. The paper examines the integration …

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