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Student Senate Meeting Minutes August 27, 2024, Student Senate-Winona State University Aug 2024

Student Senate Meeting Minutes August 27, 2024, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Minutes August 27, 2024.

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“Dead Or Alive?” Regression Imputation Of The Binary End-Of-Event Outcome Indicator For The Nemsis Public Research Dataset, Mary E. Helander Aug 2024

“Dead Or Alive?” Regression Imputation Of The Binary End-Of-Event Outcome Indicator For The Nemsis Public Research Dataset, Mary E. Helander

Social Science - All Scholarship

Objectives: Recent studies address missing survival outcomes in the National Emergency Medical Services Information System (NEMSIS), a system that stores and shares standardized EMS data from U.S. States and Territories. This study aspired to improve imputed EMS outcome accuracy and establish benchmarks for common medical emergencies treated in prehospital care. Methods: This retrospective cohort study of ground-transported EMS patients with definitive end-of-EMS-event outcomes, based on dataset years 2017 to 2023, predicted the probability of “dead” or “alive” status using logistic regression. K-fold cross-validation assessed over-fitting and internal generalization. Threshold optimization and machine learning classification metrics enabled comparison with a …

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The Impact Of The Consistent Increase Of Total Dissolved Solids On Water Quality And Its Consequences, Budoor Alsaadi Aug 2024

The Impact Of The Consistent Increase Of Total Dissolved Solids On Water Quality And Its Consequences, Budoor Alsaadi

International Programs

No abstract provided.

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Why Is The Mycobacterium Tuberculosis Beijing Genotype So Prevalent In Colón, Panama? Uncovering The Risk Factors Of A Dangerous Strain, Daniela Candanedo Aug 2024

Why Is The Mycobacterium Tuberculosis Beijing Genotype So Prevalent In Colón, Panama? Uncovering The Risk Factors Of A Dangerous Strain, Daniela Candanedo

International Programs

Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide (WHO, 2021). In Panama, TB incidence is 45.3 per 100,000 population, affecting underdeveloped areas like the Colón province (MINSA, 2023). The Beijing genotype (Lineage 2), known for its high transmissibility and multidrug resistance, poses a significant challenge (Pérez-Lago et al., 2019). A novel molecular surveillance method using allele-specific oligonucleotide PCR (ASO-PCR) was developed to identify Beijing, Haarlem and LAM genotypes in Colón, Panama (Domínguez et al., 2019). This technique detected 44.1% of Beijing strain and <5% of Haarlem and LAM strains between 2018-2020 (Acosta et al., 2020). This method was also applied between 2021-2022, identifying 29.1% of Beijing strain (Candanedo et al., 2023). This study aims to identify and analyze the epidemiological risk factors associated with the Beijing strain infection in Colón, Panama between 2025-2026. Demographic, clinical, and geographic variables will be assessed to better understand the infection and transmission dynamics. The findings will provide critical information to enhance TB control and prevention strategies in Colón, influence health policy formulation, and optimize resource allocation.

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Breaking The Silence: Addressing Stigma On Seeking Professional Mental Health Care In Rwanda Through Effective Communication, Anitha Dushimirimana Aug 2024

Breaking The Silence: Addressing Stigma On Seeking Professional Mental Health Care In Rwanda Through Effective Communication, Anitha Dushimirimana

International Programs

Mental health stigma remains a significant barrier to accessing and usage of mental health services globally, and Rwanda is no exception. According to the Rwanda Ministry of Health, one in five people between the ages of 14-65 in Rwanda has at least one mental health issue, with depression being the most common (Rwanda Ministry of Health, 2018). Despite the Ministry of Health's efforts to decentralize mental health services at community and health center levels, stigma and prejudices hinder their utilization (Mukamana et al., 2019). “Overall, 61.7% had awareness of mental health services while only 5.3% reported to have used existing …

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Impact Of A Public-Private Interface Agency For Tuberculosis Reporting During Covid-19 Pandemic In Vietnam, Lan Anh Hoang Aug 2024

Impact Of A Public-Private Interface Agency For Tuberculosis Reporting During Covid-19 Pandemic In Vietnam, Lan Anh Hoang

International Programs

Background: Viet Nam’s second prevalence survey uncovered a higher than expected burden of TB. Studies have indicated that people with TB who are ‘missed’ by existing services are equally split between those seeking care in the private sector and those not accessing healthcare. Intervention: We established a public-private interface agency (PPIA) to engage private doctors for TB treatment reporting in 14 districts across Ho Chi Minh City (HCMC) and Hai Phong, Viet Nam. Treatment data were collected and patients missing sputum results were offered an Xpert MTB/RIF test to increase the rate of bacteriologically-confirmed TB and to identify drug resistance. …

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Trends In Clinical Deterioration Events Mortality: A Call For Action, Eliana Lopez-Baron Aug 2024

Trends In Clinical Deterioration Events Mortality: A Call For Action, Eliana Lopez-Baron

International Programs

Children's mortality is still a public health concern. The World Health Organization (WHO) has been attempting to lower the death rate among children under five years old which represented the most important burden of mortality in children. In certain countries these diseases have moved from high mortality rates secondary to under-5 mortality such as infections in neonates, respiratory, and gastrointestinal disorders, to other diseases that are more commonly seen in older children and for which there is an urgent need to identify in order to improve these outcomes. An assessment of clinical deterioration events, which, if left undetected, may result …

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A Quantitative Analysis Of The Agenda Setting In Honduran Headlines During January 2024, Mario Cerna Aug 2024

A Quantitative Analysis Of The Agenda Setting In Honduran Headlines During January 2024, Mario Cerna

International Programs

The Agenda-setting theory establishes the influence of mass media over audiences, to determine which topics are of public interest and their scope and relevance. Nowadays, mass media and Hondurans also set the priority of the information broadcasted in their digital platforms. This research stablished a base line of 104 Hondurans mass media online platforms until January 2024. Six (4 newspapers, 1 TV, and 1 Radio) were selected for this study to analyze the priority of headlines and topics (political, health, crime) on its daily front pages. The key findings offer significant data such as the fact that only 3% of …

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Smart Solutions For A Cleaner Panama: Transforming Waste Management Through Data-Driven Innovation, Alex Ivan Montero Samaniego Aug 2024

Smart Solutions For A Cleaner Panama: Transforming Waste Management Through Data-Driven Innovation, Alex Ivan Montero Samaniego

International Programs

This research proposal aims to address direct improvements in the waste management system of Panama. It is grounded in an understanding of the significant challenges and limitations related to infrastructure and cultural practices. By examining case studies and examples from other countries, this research seeks to identify effective approaches to delivering feasible solutions. The ultimate goal is to create a positive impact on the health of Panamanian citizens and enhance the appearance of the city.

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Breaking The Silence: The Need For Sexual Violence Prevention Education (Svpe) In Haiti, Scindie St Fleur Aug 2024

Breaking The Silence: The Need For Sexual Violence Prevention Education (Svpe) In Haiti, Scindie St Fleur

International Programs

The purpose of this paper is to highlight the urgent need of sexual violence prevention education in Haiti. While the taboo surrounding sexual violence remains a significant obstacle to addressing these cases, the issue has become alarming due to its evolution over the last decade. Thus, the application of Dr. Jülich’s SVPE model is proposed as a more promising approach for achieving long-term positive outcomes.

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Fsec Meeting Minutes August 27, 2024, University Of Rhode Island Faculty Senate Aug 2024

Fsec Meeting Minutes August 27, 2024, University Of Rhode Island Faculty Senate

Faculty Senate Executive Committee Minutes

No abstract provided.

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Antimicrobial Studies Of Novel Pyrazole And Thiazole-Based Antibacterial Agents, Hansa Raj Kc Aug 2024

Antimicrobial Studies Of Novel Pyrazole And Thiazole-Based Antibacterial Agents, Hansa Raj Kc

Student Theses and Dissertations

In recent years, the rise of antibiotic-resistant bacteria has become a global concern, resulting in fewer effective antibiotics. Several conventional antibacterial agents are ineffective against these, necessitating novel molecules with enhanced efficacy and diverse actions. We developed pyrazole and thiazole-based antibacterial agents and demonstrated that they have significant potency (minimum inhibitory concentration as low as 0.39 µg/mL) against antibiotic-resistant and susceptible bacteria, as well as promising anti-biofilm and anti-persister activity. In vivo toxicity tests on Caenorhabditis elegans showed no significant harm to this model host organism at low compound concentrations. These compounds rescued C. elegans from methicillin-resistant Staphylococcus aureus (MRSA) …

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Srebp2 Restricts Osteoclast Differentiation And Activity By Regulating Irf7 And Limits Inflammatory Bone Erosion, Haemin Kim, In Ah Choi, Akio Umemoto, Seyeon Bae, Kaichi Kaneko, Masataka Mizuno, Eugenia Giannopoulou, Tania Pannellini, Liang Deng, Kyung-Hyun Park-Min Aug 2024

Srebp2 Restricts Osteoclast Differentiation And Activity By Regulating Irf7 And Limits Inflammatory Bone Erosion, Haemin Kim, In Ah Choi, Akio Umemoto, Seyeon Bae, Kaichi Kaneko, Masataka Mizuno, Eugenia Giannopoulou, Tania Pannellini, Liang Deng, Kyung-Hyun Park-Min

Publications and Research

Osteoclasts are multinucleated bone-resorbing cells, and their formation is tightly regulated to prevent excessive bone loss. However, the mechanisms by which osteoclast formation is restricted remain incompletely determined. Here, we found that sterol regulatory element binding protein 2 (SREBP2) functions as a negative regulator of osteoclast formation and inflammatory bone loss. Cholesterols and SREBP2, a key transcription factor for cholesterol biosynthesis, increased in the late phase of osteoclastogenesis. The ablation of SREBP2 in myeloid cells resulted in increased in vivo and in vitro osteoclastogenesis, leading to low bone mass. Moreover, deletion of SREBP2 accelerated inflammatory bone destruction in murine inflammatory …

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Editorial: Covid And Autism 2023: Lessons Learnt And Future Directions For Research, Georgina Pérez Liz, Michaela Dubay, Cecilia Montiel-Nava Aug 2024

Editorial: Covid And Autism 2023: Lessons Learnt And Future Directions For Research, Georgina Pérez Liz, Michaela Dubay, Cecilia Montiel-Nava

Psychological Science Faculty Publications

No abstract provided.

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A 72-Year-Old Man With Acute Lung Injury And Anti-Melanoma Differentiation-Associated Gene 5 Antibody: A Case Report, Irakli Lemonjava, Jose Manuel Martinez Manzano, Sahar Sultan, Rekha Bhat, Corrado Minimo, Zurab Azmaiparashvili, Sadia Benzaquen Aug 2024

A 72-Year-Old Man With Acute Lung Injury And Anti-Melanoma Differentiation-Associated Gene 5 Antibody: A Case Report, Irakli Lemonjava, Jose Manuel Martinez Manzano, Sahar Sultan, Rekha Bhat, Corrado Minimo, Zurab Azmaiparashvili, Sadia Benzaquen

Einstein Health Papers

Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA-5 Ab) is associated with amyopathic dermatomyositis (DM). These patients are particularly at high-risk for developing acute and rapidly progressive interstitial lung disease (ILD). Given the lack of muscle-related symptoms, along with its sudden onset and rapid clinical progression, the diagnosis of anti-MDA-5 Ab + ILD represents a challenge for clinicians. Even after the diagnosis is established, prognosis remains dismal owing to a hyperinflammatory state, mimicking cytokine storm, commonly refractory to potent immunosuppressive therapy. Hence, we present an elderly African American man who developed acute and rapidly progressive ILD in the setting of positive anti-MDA5 …

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Role Of Kindlin 2 In Prostate Cancer, Katarzyna Bialkowska, Lamyae El Khalki, Priyanka Rana, Wei Wang, Daniel Lindner, Yvonne Parker, Lucia Languino, Dario Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward Plow Aug 2024

Role Of Kindlin 2 In Prostate Cancer, Katarzyna Bialkowska, Lamyae El Khalki, Priyanka Rana, Wei Wang, Daniel Lindner, Yvonne Parker, Lucia Languino, Dario Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward Plow

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Kindlin-2 is a cytoskeletal adapter protein that is present in many different cell types. By virtue of its interaction with multiple binding partners, Kindlin-2 intercalates into numerous signaling pathways and cytoskeletal nodes. A specific interaction of Kindlin-2 that is of paramount importance in many cellular responses is its direct binding to the cytoplasmic tails of integrins, an interaction that controls many of the adhesive, migratory and signaling responses mediated by members of the integrin family of cell-surface heterodimers. Kindlin-2 is highly expressed in many cancers and is particularly prominent in prostate cancer cells. CRISPR/cas9 was used as a primary approach …

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Welcoming The Classes Of 2027 And 2028 At Nyls’S 2024 Orientation, Jennifer Bancamper Aug 2024

Welcoming The Classes Of 2027 And 2028 At Nyls’S 2024 Orientation, Jennifer Bancamper

NYLS Community News

No abstract provided.

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Implementing A Dayroom For Acute Care Patients With Dementia, Darcy Copeland, Karla Call Aug 2024

Implementing A Dayroom For Acute Care Patients With Dementia, Darcy Copeland, Karla Call

General Submissions: Presentations (Oral and Poster)

The purpose of this EBP (Evidence Based Practice) project was to reduce restraint use and length of stay among patients with dementia admitted to an acute care unit.

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Aged-Out Foster Youths’ Exposure To Spiritual Foster Homes And Transition Into Adulthood, Dr. Valerie Elaine Sims Aug 2024

Aged-Out Foster Youths’ Exposure To Spiritual Foster Homes And Transition Into Adulthood, Dr. Valerie Elaine Sims

Walden Dissertations and Doctoral Studies

There are 438,000 children and youth in foster care in the United States; almost 46,000 are aged 16 or older, and over 20,000 “age out” of many child welfare services between ages 18 and 20 every year. This qualitative phenomenological study aimed to explore the lived experience of foster youth growing up in a spiritual foster home (incorporating religious belief, practice, higher power, Bible study, or youth groups) and aging out of the system through the lens of faith-based theory. This study had a sample size of eight participants, ages 18 to 25, who transitioned out of the foster care …

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Donor Types And Outcomes Of Transplantation In Myelofibrosis: A Cibmtr Study, Tania Jain, Noel Estrada-Merly, M Queralt Salas, Soyoung Kim, Jakob Devos, Min Chen, Xi Fang, Rajat Kumar, Marcio Andrade-Campos, Hany Elmariah, Vaibhav Agrawal, Mahmoud Aljurf, Ulrike Bacher, Talha Badar, Sherif M Badawy, Karen Ballen, Amer Beitinjaneh, Vijaya Raj Bhatt, Christopher Bredeson, Zachariah Defilipp, Bhagirathbhai Dholaria, Nosha Farhadfar, Shatha Farhan, Arpita P Gandhi, Siddhartha Ganguly, Usama Gergis, Michael R Grunwald, Nada Hamad, Betty K Hamilton, Yoshihiro Inamoto, Madiha Iqbal, Omer Jamy, Mark Juckett, Mohamed A Kharfan-Dabaja, Maxwell M Krem, Deepesh P Lad, Jane Liesveld, Monzr M Al Malki, Adriana K Malone, Hemant S Murthy, Guillermo Ortí, Sagar S Patel, Attaphol Pawarode, Miguel-Angel Perales, Marjolein Van Der Poel, Olle Ringden, David A Rizzieri, Alicia Rovó, Bipin N Savani, Mary Lynn Savoie, Sachiko Seo, Melhem Solh, Celalettin Ustun, Leo F Verdonck, John R Wingard, Baldeep Wirk, Nelli Bejanyan, Richard J Jones, Taiga Nishihori, Betul Oran, Ryotaro Nakamura, Bart Scott, Wael Saber, Vikas Gupta Aug 2024

Donor Types And Outcomes Of Transplantation In Myelofibrosis: A Cibmtr Study, Tania Jain, Noel Estrada-Merly, M Queralt Salas, Soyoung Kim, Jakob Devos, Min Chen, Xi Fang, Rajat Kumar, Marcio Andrade-Campos, Hany Elmariah, Vaibhav Agrawal, Mahmoud Aljurf, Ulrike Bacher, Talha Badar, Sherif M Badawy, Karen Ballen, Amer Beitinjaneh, Vijaya Raj Bhatt, Christopher Bredeson, Zachariah Defilipp, Bhagirathbhai Dholaria, Nosha Farhadfar, Shatha Farhan, Arpita P Gandhi, Siddhartha Ganguly, Usama Gergis, Michael R Grunwald, Nada Hamad, Betty K Hamilton, Yoshihiro Inamoto, Madiha Iqbal, Omer Jamy, Mark Juckett, Mohamed A Kharfan-Dabaja, Maxwell M Krem, Deepesh P Lad, Jane Liesveld, Monzr M Al Malki, Adriana K Malone, Hemant S Murthy, Guillermo Ortí, Sagar S Patel, Attaphol Pawarode, Miguel-Angel Perales, Marjolein Van Der Poel, Olle Ringden, David A Rizzieri, Alicia Rovó, Bipin N Savani, Mary Lynn Savoie, Sachiko Seo, Melhem Solh, Celalettin Ustun, Leo F Verdonck, John R Wingard, Baldeep Wirk, Nelli Bejanyan, Richard J Jones, Taiga Nishihori, Betul Oran, Ryotaro Nakamura, Bart Scott, Wael Saber, Vikas Gupta

Department of Medical Oncology Faculty Papers

We evaluate the impact of donor types on outcomes of hematopoietic cell transplantation (HCT) in myelofibrosis, using the Center for International Blood and Marrow Transplant Research registry data for HCTs done between 2013 and 2019. In all 1597 patients, the use of haploidentical donors increased from 3% in 2013 to 19% in 2019. In study-eligible 1032 patients who received peripheral blood grafts for chronic-phase myelofibrosis, 38% of recipients of haploidentical HCT were non-White/Caucasian. Matched sibling donor (MSD)-HCTs were associated with superior overall survival (OS) in the first 3 months (haploidentical hazard ratio [HR], 5.80 [95% confidence interval (CI), 2.52-13.35]; matched …

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Student Affairs Minutes 08/27/2024, Student Affairs Committee Aug 2024

Student Affairs Minutes 08/27/2024, Student Affairs Committee

Student Affairs Committee

No abstract provided.

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Whole Genome And Reverse Protein Phase Array Landscapes Of Patient Derived Osteosarcoma Xenograft Models, Chia-Chin Wu, Licai Huang, Zhongting Zhang, Zhenlin Ju, Xingzhi Song, E Anders Kolb, Wendong Zhang, Jonathan Gill, Min Ha, Malcolm A Smith, Peter Houghton, Christopher L Morton, Raushan Kurmasheva, John Maris, Yael Mosse, Yiling Lu, Richard Gorlick, P Andrew Futreal, Hannah C Beird Aug 2024

Whole Genome And Reverse Protein Phase Array Landscapes Of Patient Derived Osteosarcoma Xenograft Models, Chia-Chin Wu, Licai Huang, Zhongting Zhang, Zhenlin Ju, Xingzhi Song, E Anders Kolb, Wendong Zhang, Jonathan Gill, Min Ha, Malcolm A Smith, Peter Houghton, Christopher L Morton, Raushan Kurmasheva, John Maris, Yael Mosse, Yiling Lu, Richard Gorlick, P Andrew Futreal, Hannah C Beird

Faculty, Staff and Student Publications

Osteosarcoma is the most common primary bone malignancy in children and young adults, and it has few treatment options. As a result, there has been little improvement in survival outcomes in the past few decades. The need for models to test novel therapies is especially great in this disease since it is both rare and does not respond to most therapies. To address this, an NCI-funded consortium has characterized and utilized a panel of patient-derived xenograft models of osteosarcoma for drug testing. The exomes, transcriptomes, and copy number landscapes of these models have been presented previously. This study now adds …

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Evaluating The Impact Of Laboratory-Based Eligibility Criteria By Race/Ethnicity In First-Line Clinical Trials Of Dlbcl, Arushi Khurana, Raphael Mwangi, Loretta J Nastoupil, Patrick M Reagan, Umar Farooq, Jason T Romancik, Timothy J Mcdonnell, Shaun M Riska, Lzidore S Lossos, Brad S Kahl, Peter Martin, Thomas E Witzig, James R Cerhan, Christopher R Flowers, Grzegorz S Nowakowski, Matthew J Maurer Aug 2024

Evaluating The Impact Of Laboratory-Based Eligibility Criteria By Race/Ethnicity In First-Line Clinical Trials Of Dlbcl, Arushi Khurana, Raphael Mwangi, Loretta J Nastoupil, Patrick M Reagan, Umar Farooq, Jason T Romancik, Timothy J Mcdonnell, Shaun M Riska, Lzidore S Lossos, Brad S Kahl, Peter Martin, Thomas E Witzig, James R Cerhan, Christopher R Flowers, Grzegorz S Nowakowski, Matthew J Maurer

Faculty, Staff and Student Publications

Underrepresentation of racial and ethnic subgroups in cancer clinical trials remains a persistent challenge. Restrictive clinical trial eligibility criteria have been shown to exacerbate this problem. We previously identified that up to 24% of patients treated with standard immunochemotherapy would have been excluded from recent first-line trials in diffuse large B-cell lymphoma (DLBCL) based on 5 laboratory-based criteria. These ineligible patients had worse clinical outcomes and increased deaths related to lymphoma progression, suggesting the potential exclusion of patients who could have benefited most from the novel therapies being evaluated. Using data from the prospectively enrolled Lymphoma Epidemiology Outcomes cohort study, …

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Multicenter, Phase 1 Study Of Etavopivat (Ft-4202) Treatment For Up To 12 Weeks In Patients With Sickle Cell Disease, Santosh L Saraf, Robert Hagar, Modupe Idowu, Ifeyinwa Osunkwo, Kimberly Cruz, Frans A Kuypers, R Clark Brown, James Geib, Maria Ribadeneira, Patricia Schroeder, Eric Wu, Sanjeev Forsyth, Patrick F Kelly, Theodosia A Kalfa, Marilyn J Telen Aug 2024

Multicenter, Phase 1 Study Of Etavopivat (Ft-4202) Treatment For Up To 12 Weeks In Patients With Sickle Cell Disease, Santosh L Saraf, Robert Hagar, Modupe Idowu, Ifeyinwa Osunkwo, Kimberly Cruz, Frans A Kuypers, R Clark Brown, James Geib, Maria Ribadeneira, Patricia Schroeder, Eric Wu, Sanjeev Forsyth, Patrick F Kelly, Theodosia A Kalfa, Marilyn J Telen

Faculty, Staff and Student Publications

Etavopivat is an investigational, once daily, oral, selective erythrocyte pyruvate kinase (PKR) activator. A multicenter, randomized, placebo-controlled, double-blind, 3-part, phase 1 study was conducted to characterize the safety and clinical activity of etavopivat. Thirty-six patients with sickle cell disease (SCD) were enrolled into 4 cohorts: 1 single-dose, 2 multiple ascending doses, and 1 open-label (OL). In the OL cohort, 15 patients (median age 33.0 years [range, 17-55]) received 400 mg etavopivat once daily for 12 weeks; 14 patients completed treatment. Consistent with the mechanism of PKR activation, increases in adenosine triphosphate and decreases in 2,3-diphosphoglycerate were observed and sustained over …

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Instruments For Dual-Factor Mental Health Screening In Elementary Schools: Implications In Mental Health Classification, Mei-Ki Chan, Michael J. Furlong, Emmy Ruff Aug 2024

Instruments For Dual-Factor Mental Health Screening In Elementary Schools: Implications In Mental Health Classification, Mei-Ki Chan, Michael J. Furlong, Emmy Ruff

Psychology Faculty Publications

This research study holds practical significance for educators, school administrators, and mental health professionals. The study utilized structural equation modeling on two samples of elementary school students in grades three to five to create and validate condensed versions of the Social-Emotional Health Survey-Primary and the Me and My School questionnaire. These abbreviated scales exhibited strong internal validity and reliability across grade levels and genders, allowing for the assessment of wellness and distress among a diverse range of elementary school students. Furthermore, data from a longitudinal sample investigated dual-factor mental health profiles and their consistency over one year. Based on the …

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Neutralization Escape, Infectivity, And Membrane Fusion Of Jn1-Derived Sars-Cov-2 Slip, Flirt, And Kp2 Variants, Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Kai Xu, Shan-Lu Liu Aug 2024

Neutralization Escape, Infectivity, And Membrane Fusion Of Jn1-Derived Sars-Cov-2 Slip, Flirt, And Kp2 Variants, Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Kai Xu, Shan-Lu Liu

Faculty, Staff and Student Publications

We investigate JN.1-derived subvariants SLip, FLiRT, and KP.2 for neutralization by antibodies in vaccinated individuals, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients, or class III monoclonal antibody S309. Compared to JN.1, SLip, KP.2, and especially FLiRT exhibit increased resistance to bivalent-vaccinated and BA.2.86/JN.1-wave convalescent human sera. XBB.1.5 monovalent-vaccinated hamster sera robustly neutralize FLiRT and KP.2 but have reduced efficiency for SLip. All subvariants are resistant to S309 and show decreased infectivity, cell-cell fusion, and spike processing relative to JN.1. Modeling reveals that L455S and F456L in SLip reduce spike binding for ACE2, while R346T in FLiRT and KP.2 strengthens …

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Nonreciprocity In Chikv And Mayv Vaccine-Elicited Protection, Whitney C Weber, Takeshi F Andoh, Craig N Kreklywich, Zachary J Streblow, Michael Denton, Magdalene M Streblow, John M Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T Curiel, Nicole N Haese, Daniel N Streblow Aug 2024

Nonreciprocity In Chikv And Mayv Vaccine-Elicited Protection, Whitney C Weber, Takeshi F Andoh, Craig N Kreklywich, Zachary J Streblow, Michael Denton, Magdalene M Streblow, John M Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T Curiel, Nicole N Haese, Daniel N Streblow

2020-Current year OA Pubs

Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use. Mayaro virus (MAYV) is a related emerging alphavirus with epidemic potential with circulation overlap potential with CHIKV. We previously reported the ability of a non-replicating human adenovirus (AdV)-vectored vaccine expressing the MAYV structural polyprotein to protect against disease in mice following challenge with MAYV, CHIKV and UNAV. Herein, we evaluated mouse immunity and protective efficacy for an AdV-CHIKV full structural polyprotein vaccine in combination with heterologous AdV-MAYV prime/boost regimens versus vaccine coadministration. Heterologous prime/boost regimens skewed immunity toward …

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A Rad18-Ubc13-Palb2-Rnf168 Axis Mediates Replication Fork Recovery In Brca1-Deficient Cancer Cells, Emily Cybulla, Sierra Wallace, Alice Meroni, Jessica Jackson, Sumedha Agashe, Mithila Tennakoon, Mangsi Limbu, Annabel Quinet, Elena Lomonosova, Hollie Noia, Stephanie Tirman, Matthew Wood, Alessandro Vindigni, Et Al. Aug 2024

A Rad18-Ubc13-Palb2-Rnf168 Axis Mediates Replication Fork Recovery In Brca1-Deficient Cancer Cells, Emily Cybulla, Sierra Wallace, Alice Meroni, Jessica Jackson, Sumedha Agashe, Mithila Tennakoon, Mangsi Limbu, Annabel Quinet, Elena Lomonosova, Hollie Noia, Stephanie Tirman, Matthew Wood, Alessandro Vindigni, Et Al.

2020-Current year OA Pubs

BRCA1/2 proteins function in genome stability by promoting repair of double-stranded DNA breaks through homologous recombination and by protecting stalled replication forks from nucleolytic degradation. In BRCA1/2-deficient cancer cells, extensively degraded replication forks can be rescued through distinct fork recovery mechanisms that also promote cell survival. Here, we identified a novel pathway mediated by the E3 ubiquitin ligase RAD18, the E2-conjugating enzyme UBC13, the recombination factor PALB2, the E3 ubiquitin ligase RNF168 and PCNA ubiquitination that promotes fork recovery in BRCA1- but not BRCA2-deficient cells. We show that this pathway does not promote fork recovery by preventing replication fork reversal …

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Selective Androgen Receptor Modulators Leading To Liver Injury: A Case Report, Michael R. Demangone, Karam R. Abi Karam, Joshua Li Aug 2024

Selective Androgen Receptor Modulators Leading To Liver Injury: A Case Report, Michael R. Demangone, Karam R. Abi Karam, Joshua Li

Student Publications

Selective androgen receptor modulators (SARMs) have gained popularity for their alleged ability to selectively target androgen receptors, potentially offering muscle-building benefits with fewer side effects than traditional steroids. However, the safety profile of SARMs, including RAD-140, is not fully understood. This case report presents a 29-year-old male who developed liver injury after taking RAD-140. The patient experienced jaundice and elevated liver enzymes after three months of RAD-140 use. A liver ultrasound revealed hepatic steatosis and a hyperechoic lesion. Symptoms resolved after discontinuing RAD-140. Similar cases of liver injury associated with RAD-140 have been reported, highlighting the potential hepatotoxicity of this …

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Pipe Dream: Remyelination Therapy For Multiple Sclerosis, Benjamin Deneen Aug 2024

Pipe Dream: Remyelination Therapy For Multiple Sclerosis, Benjamin Deneen

Faculty, Staff and Students Publications

No abstract provided.

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