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Assessing The Cost Of Urban Climate Resilience: An Analysis Of The Nyc Financial District And Seaport Climate Resilience (Fidi) Master Plan Implementation, Caroline Welter, Daniel Centuriao

Regional Research Institute Working Papers

New York City is set to implement the Financial District and Seaport Climate Resilience Master Plan (FiDi), aiming to develop infrastructure capable of addressing or mitigating the effects of climate change on Lower Manhattan. This area faces significant risks from daily tidal flooding, rainfall, coastal storms, hurricane effects, and rising temperatures. With an estimated investment of $5 to $7 billion to be spent over 15 years, our study focuses on estimating the plan’s economic impacts in Lower Manhattan, across other boroughs of New York City, and throughout the entire state. We utilize a multi-regional input-output (MRIO) modeling approach, constructing the …

Earning Accruals In Complex Firms: The Case Of Multi-Jurisdictional And Multi-Product Insurers, Willie Dion Reddic, M. Martin Boyer

The Lender Center for Social Justice

This working paper investigates accrual earnings management in complex insurance firms that operate across multiple jurisdictions and product lines. It highlights how firm complexity influences financial reporting and regulatory oversight.

Manifest Health Theory: A Holistic Approach To Cis-Gender Men’S Health, Julian L. Gallegos

School of Nursing Faculty Publications

Men’s health has often been overlooked in health care, with traditional gender norms and societal expectations significantly shaping men’s health behaviors and attitudes. The MANifest Health Theory (MHT) offers a comprehensive framework to address cis-gender men’s unique health needs by considering the complex interplay of biological, psychological, and social factors. Rooted in four interconnected core concepts—Biopsychosocial Model, Health Optimization, Health Synchronicity, and Ethnocultural Expression—MHT provides a holistic understanding of men’s health. This article explores how MHT integrates inductive and deductive reasoning, describing, explaining, predicting, and controlling aspects of men’s health. Key components such as Gender-Sensitive Care, Health Empowerment, Supportive Environments, …

Economic Impact Considerations For Sustainable Design Engineering As Derived From The Literature, K. Joshua Kelley, Christopher A. Mattson, Nile Hatch, John L. Salmon

Undergraduate Honors Theses

This thesis contributes to the scholarship on sustainable development by presenting a review of the literature on the economic impacts of engineering design decisions and engineered products. Many design engineers already consider the economic impacts of their work, especially those impacts related to production cost and the economic feasibility of their products. However, we believe that a review of our findings can help design engineers consider a more comprehensive set of economic impacts that apply to their work, leading to greater sustainability. Presented in this thesis are 11 economic impact categories, spanning three economic scopes.

2024 August 28; Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes, 2024 August 28

Subjective And Objective Sleep Quality Assessment In Adolescent Patients With Inflammatory Bowel Disease, Holly Breeden, Elizabeth Mcdonough, Amanda Glinky, Rebecca Wallace, Robbie Beyl, Colleen Leblanc

School of Medicine Faculty Publications

Objectives: There is a link between inflammatory bowel disease (IBD) and poor sleep quality that is presumed to be multifactorial. The purpose of this study was to identify factors that impact sleep quality in this group including clinical disease activity, depression, anxiety, quality of life, and disordered social media use through questionnaires. Methods: This prospective study analyzed sleep quality in adolescent patients ages 13 to 18 with a diagnosis of IBD using objective data from wrist actigraphy and subjective report from the Pittsburgh Sleep Quality Index (PSQI). Additional screeners including the Short Pediatric Crohn's Disease Activity Index or Pediatric Ulcerative …

Lipopolysaccharide Immune Challenge Stress Biomarkers In Livestock: A Review, Mimosa Medeiros

Honors Scholar Theses

Lipopolysaccharides (LPS) are a critical component of the cell wall in gram-negative bacteria and play a notable role in the host immune system's response to infection. The LPS challenge, involving the administration of exogenous bacterial LPS to replicate host immune response, provides insight into host responses to inflammatory diseases. Monitoring this response through various stress biomarkers such as serum cytokines, chemokines, white blood cell populations, rectal temperature, and cortisol concentrations enables the understanding of systemic metabolic changes and stress phenotyping. LPS research has the potential to make a significant contribution to the development of stress-resilient livestock. This is particularly important …

Synergistic Effects Of Novel Penicillin-Binding Protein 1a Amino Acid Substitutions Contribute To High-Level Amoxicillin Resistance Of, Alain Cimuanga-Mukanya, Evariste Tshibangu-Kabamba, Patrick De Jesus Ngoma Kisoko, Kartika Afrida Fauzia, Fabien Mbaya Tshibangu, Antoine Tshimpi Wola, Pascal Tshiamala Kashala, Dieudonné Mumba Ngoyi, Steve Ahuka-Mundeke, Gunturu Revathi, Ghislain Disashi-Tumba, Yasutoshi Kido, Takashi Matsumoto, Junko Akada, Yoshio Yamaoka

Faculty, Staff and Students Publications

The growing resistance to amoxicillin (AMX)—one of the main antibiotics used in Helicobacter pylori eradication therapy—is an increasing health concern. Several mutations of penicillin-binding protein 1A (PBP1A) are suspected of causing AMX resistance; however, only a limited set of these mutations have been experimentally explored. This study aimed to investigate four PBP1A mutations (i.e., T558S, N562H, T593A, and G595S) carried by strain KIN76, a high-level AMX-resistant clinical H. pylori isolate with an AMX minimal inhibition concentration (MIC) of 2 µg/mL. We transformed a recipient strain 26695 with the DNA containing one to four mutation allele combinations of the pbp1 gene …

Recurrent High Grade Serous Endometrial Cancer With Brain Metastases: Immunotherapy Confers Improved Quality Of Life And Survival, Kierany B. Shelvin, Jill Vincent, Shawna Morron, Michael Morin, Aaron Mammoser, Navya Nair

School of Medicine Faculty Publications

No abstract provided.

Reducing Emergency Room To Inpatient Disposition Time, Kyle Disney, Beyli Disney

DNP and Student Works

Prolonged boarding times in the emergency department negatively impact patient outcomes, leading to increased mortality, infection rates, and decreased patient satisfaction. Effective and timely communication during handoffs between healthcare professionals is crucial to minimize these delays and improve overall patient care, with the use of standardized handoff tools significantly reducing adverse events and length of hospital stay. This Doctor of Nursing Practice (DNP) project investigated the impact of implementing a handoff tool on decreasing emergency room to medical surgical unit disposition time. Kurt Lewin's three-step model of change, popular among healthcare organizations, was used as the theoretical framework for this …

Fpca-Setcn: A Novel Deep Learning Framework For Remaining Useful Life Prediction, Junde Chen, Yuxin Wen, Xuxue Sun, Adnan Zeb, Mohammad Saleh Meiabadi, Sasan Sattarpanah Karganroudi

Engineering Faculty Articles and Research

The accurate prediction of remaining useful life (RUL) can serve as a reliable foundation for equipment maintenance, thereby effectively reducing the incidence of failure and maintenance costs. In this study, a novel deep learning (DL) framework that incorporates functional principal component analysis (FPCA) and enhanced temporal convolutional network (TCN) is proposed for RUL prediction. Precisely, FPCA is employed to capture the changing patterns in multistream degradation trajectories. Subsequently, the reconstructed signals from FPCA are fed into a convolutional block for extracting deep-level features. An enhanced squeeze-and-excitation (ESE) block is then incorporated into the network for adaptive feature recalibration, enhancing the …

High Functioning Females And Dating, Myla M. Streander

Walden Dissertations and Doctoral Studies

The autism population in Southwest Florida does not have resources in the community to assist them with general living skills, social skills, job skills, and relationship skills. The research shows that autistic females have been ignored for years as they do not present autism the same as males. This means that instead of being independent and functional, they depend on the government for complete assistance. The study completed involved nine women with autism ages 18-35 to record their experiences and what gaps in the practice need to be addressed. This study was completed via Zoom and phone interviews, depending on …

Financial Resilience Of Nonprofits In The Postpandemic Future, Kristofer Alan Vaughn

Walden Dissertations and Doctoral Studies

Nonprofit organizations periodically conduct strength, weaknesses, opportunities, and threats (SWOT) analyses; especially after the disrupting effects of the covid pandemic. A Northern California community-based nonprofit organization, deploys 36 volunteers to support the community. The struggles to maintain an annual budget, primarily through grants and personal contributions, to operate programs. The purpose of this study was to investigate several strategies to build a sustainable annual resource development plan. A SWOT analysis of the organization was to aid in the creation of a resource development plan. This general qualitative case study explored the insight of key volunteers and secondary documents analysis to …

Human Resources Strategies To Improve Performance In Healthcare Organizations, Rashida Ratliff

Walden Dissertations and Doctoral Studies

Performance management in healthcare organizations remains an ongoing challenge for leaders. Healthcare leaders are focused on increasing performance because it is the leading indicator of improving overall patient quality of care. Grounded in Kurt Lewin’s change management theory, the purpose of this pragmatic inquiry was to explore human resource strategies healthcare leaders use to enhance organizational processes and systems to improve performance. The participants were seven leaders in healthcare organizations who incorporated human resource strategies in managing performance. Data were collected using semistructured interviews, reviews of public data of business websites, and human resource strategies for managing performance. Through thematic …

Utilizing Effective Performance Management Strategies To Advance Towards Organizational Success, Raina Nicole Johnson-Smith

Walden Dissertations and Doctoral Studies

Poor employee performance has a direct impact on business outcomes. Performance management leaders are concerned with identifying and implementing efficient strategies, as organizational performance is a primary predictor of the organization’s success and sustainability. Grounded in the transformational leadership theory, the purpose of this qualitative, pragmatic inquiry study was to explore effective performance management strategies to identify and remediate performance issues. The participants were seven dynamic performance management leaders in the northeastern United States who utilized effective strategies to identify and remediate performance issues. Data were collected using semistructured interviews, performance management websites, and public records. Through thematic analysis, four …

Mechanisms And Metabolic Consequences Of Adipocyte Progenitor Replicative Senescence, Tonghui Lin, Aftab Mohammad, Mikhail G Kolonin, Kristin L Eckel-Mahan

Faculty, Staff and Student Publications

In recent decades, obesity has become a worldwide epidemic. As a result, the importance of adipose tissue (AT) as a metabolically active storage depot for lipids and a key mediator of body-wide metabolism and energy balance has been increasingly recognized. Emerging from the studies of AT in metabolic disease is a recognition of the importance of the adipocyte progenitor cell (APC) population of AT being the gatekeeper of adipocyte function. APCs have the capability to self-renew and undergo adipogenesis to propagate new adipocytes capable of lipid storage, which is important for maintaining a healthy fat pad, devoid of dysfunctional lipid …

A Metabolite-Based Liquid Biopsy For Detection Of Ovarian Cancer, Johannes F Fahrmann, Seyyed Mahmood Ghasemi, Chae Y Han, Ranran Wu, Jennifer B Dennison, Jody Vykoukal, Joseph Celestino, Karen Lu, Zhen Lu, Charles Drescher, Kim-Anh Do, Samir Hanash, Robert C Bast, Ehsan Irajizad

Faculty, Staff and Student Publications

Serial CA125 and second line transvaginal ultrasound (TVS) screening in the UKCTOCS indicated a shift towards detection of earlier stage ovarian cancer (OvCa), but did not yield a significant mortality reduction. There remains a need to establish additional biomarkers that can complement CA125 for even earlier and at a larger proportion of new cases. Using a cohort of plasma samples from 219 OvCa cases (59 stage I/II and 160 stage III/IV) and 409 female controls and a novel Sensitivity Maximization At A Given Specificity (SMAGS) method, we developed a blood-based metabolite-based test consisting of 7 metabolites together with CA125 for …

Hpi 101 Introduction To Health Care Professions, Cherryle Brown

Open Educational Resources

The document is a syllabus for the "HPI 101: Introduction to Healthcare Professions" course offered in Fall 2024 by Lehman College, City University of New York. The course is designed as a hybrid, synchronous learning experience with in-person sessions. It aims to provide students with an introductory understanding of the U.S. healthcare system, diverse healthcare careers, and the foundational skills necessary for success in the healthcare industry.

Key topics include the structure of the U.S. healthcare system, the roles and responsibilities of healthcare professionals, safety protocols, interpersonal communication, and basic medical terminology. The syllabus outlines various learning objectives, such as …

The Bg News August 28, 2024, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. August 28, 2024. Volume 104-Issue 01.

Midweek Memo, Georgia Southern University

Midweek Memo

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Lindenwood Digest, August 28, 2024, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Systematic Transcriptomic Analysis Of Childhood Medulloblastoma Identifies N6-Methyladenosine-Dependent Lncrna Signatures Associated With Molecular Subtype, Immune Cell Infiltration, And Prognosis, Kandarp Joshi, Menglang Yuan, Keisuke Katsushima, Olivier Saulnier, Animesh Ray, Ernest Amankwah, Stacie Stapleton, George Jallo, Michael D Taylor, Charles G Eberhart, Ranjan J Perera

Faculty, Staff and Students Publications

Medulloblastoma, the most common malignant pediatric brain tumor, is classified into four main molecular subgroups, but group 3 and group 4 tumors are difficult to subclassify and have a poor prognosis. Rapid point-of-care diagnostic and prognostic assays are needed to improve medulloblastoma risk stratification and management. N6-methyladenosine (m6A) is a common RNA modification and long non-coding RNAs (lncRNAs) play a central role in tumor progression, but their impact on gene expression and associated clinical outcomes in medulloblastoma are unknown. Here we analyzed 469 medulloblastoma tumor transcriptomes to identify lncRNAs co-expressed with m6A regulators. Using LASSO-Cox analysis, we identified a five-gene …

Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Residential Metals Abatement Program (Rmap) Yard Submittals Round 2 (Dated July 25, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Silver Bow Creek Conservation Area Repository Data Gap Quality Assurance Project Plan Request For Change To Install Additional Test Pits And Perform Material Characterization, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2024 Spring Migration Seasonal Report For Berkeley Pit Waterfowl Protection Plan, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Understanding Associations Between Disasters And Sustainability, Resilience, And Poverty: An Empirical Study Of The Last Two Decades, Dean Kyne, Dominic Kyei

Sociology Faculty Publications

This study investigates the impact of disasters on sustainability, resilience, and poverty, using data from the “Sustainable Development Report” and the Emergency Events Database (EM-DAT) from 2000 to 2023. Regression models assessed the effects of disasters, deaths, injuries, affected individuals, and economic damage on normalized values of the dependent variables with lag periods of one, two, and three years of independent variables. The results reveal that disasters consistently negatively impact sustainability and resilience, highlighting the need for robust disaster risk reduction strategies and resilient infrastructure. Higher mortality rates significantly hindered development, emphasizing the importance of improving early warning systems, emergency …

Adenovirus Vaccine Targeting Kinases Induces Potent Antitumor Immunity In Solid Tumors, Fei Zhu, Zheng Lu, Wenjing Tang, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Lin Fang, Huizhong Li, Gang Wang, Renjin Chen, Junnian Zheng, Dafei Chai

Faculty, Staff and Students Publications

BACKGROUND: Targeting kinases presents a potential strategy for treating solid tumors; however, the therapeutic potential of vaccines targeting kinases remains uncertain.

METHODS: Adenovirus (Ad) vaccines encoding Aurora kinase A (AURKA) or cyclin-dependent kinase 7 (CDK7) were developed, and their therapeutic potentials were investigated by various methods including western blot, flow cytometry, cytotoxic T lymphocyte assay, and enzyme-linked immunospot (ELISpot), in mouse and humanized solid tumor models.

RESULTS: Co-immunization with Ad-AURKA/CDK7 effectively prevented subcutaneous tumor growth in the Renca, RM-1, MC38, and Hepa1-6 tumor models. In therapeutic tumor models, Ad-AURKA/CDK7 treatment impeded tumor growth and increased immune cell infiltration. Administration of …

Carbohydrate Restriction-Induced Elevations In Ldl-Cholesterol And Atherosclerosis: The Keto Trial, Jonathan Fialkow, Ricardo Cury, Theodore Feldman

All Publications

Background: Increases in low-density lipoprotein cholesterol (LDL-C) can occur on carbohydrate restricted ketogenic diets. Lean metabolically healthy individuals with a low triglyceride-to-high-density lipoprotein cholesterol ratio appear particularly susceptible, giving rise to the novel "lean mass hyper-responder" (LMHR) phenotype.

Objectives: The purpose of the study was to assess coronary plaque burden in LMHR and near-LMHR individuals with LDL-C ≥190 mg/dL (ketogenic diet [KETO]) compared to matched controls with lower LDL-C from the Miami Heart (MiHeart) cohort.

Methods: There were 80 KETO individuals with carbohydrate restriction-induced LDL-C ≥190 mg/dL, high-density lipoprotein cholesterol ≥60 mg/dL, and triglyceride levels ≤80 mg/dL, without familial hypercholesterolemia, …

Diet-Induced Obesity Induces Transcriptomic Changes In Neuroimmunometabolic-Related Genes In The Striatum And Olfactory Bulb, Rosario B Jaime-Lara, Claudia Colina-Prisco, Marcel De Jesus Vega, Sarah Williams, Ted Usdin, Bridget Matikainen-Ankney, Alayna Kinkead, Brianna Brooks, Yupeng Wang, Alexis T Franks, Alexxai Kravitz, Paule V Joseph

2020-Current year OA Pubs

The incidence of obesity has markedly increased globally over the last several decades and is believed to be associated with the easier availability of energy-dense foods, including high-fat foods. The reinforcing hedonic properties of high-fat foods, including olfactory cues, activate reward centers in the brain, motivating eating behavior. Thus, there is a growing interest in the understanding of the genetic changes that occur in the brain that are associated with obesity and eating behavior. This growing interest has paralleled advances in genomic methods that enable transcriptomic-wide analyses. Here, we examined the transcriptomic-level differences in the olfactory bulb and striatum, regions …

Signaling Modulation Mediated By Ligand Water Interactions With The Sodium Site At Μor, Rohini S Ople, Nokomis Ramos-Gonzalez, Sarah M Bernhard, Kevin Appourchaux, Sashrik Sribhashyam, Balazs R Varga, Susruta Majumdar, Et Al.

2020-Current year OA Pubs

The mu opioid receptor (μOR) is a target for clinically used analgesics. However, adverse effects, such as respiratory depression and physical dependence, necessitate the development of alternative treatments. Recently we reported a novel strategy to design functionally selective opioids by targeting the sodium binding allosteric site in μOR with a supraspinally active analgesic named