Digital Commons Network^™

Medicinally Privileged Natural Chalcones: Abundance, Mechanisms Of Action, And Clinical Trials, Sophia M. Villa, Justin Z. Heckman, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Chalcones have been utilized for centuries as foods and medicines across various cultures and traditions worldwide. This paper concisely overviews their biosynthesis as specialized metabolites in plants and their significance, potential, efficacy, and possibility as future medicines. This is followed by a more in-depth exploration of naturally occurring chalcones and their corresponding mechanisms of action in human bodies. Based on their mechanisms of action, chalcones exhibit many pharmacological properties, including antioxidant, anti-inflammatory, anticancer, antimalarial, antiviral, and antibacterial properties. Novel naturally occurring chalcones are also recognized as potential antidiabetic drugs, and their effect on the GLUT-4 transporter is investigated. In addition, …

Development Of Tissue-Engineered Model Of Fibrotic Scarring After Spinal Cord Injury To Study Astrocyte Activation And Neurite Outgrowth In Vitro, Nikolas Ala-Kokko, Inha Baek, Younghye Song

Biomedical Engineering Faculty Publications and Presentations

Traumatic spinal cord injuries (SCI) are debilitating injuries affecting twenty-seven million people worldwide and cause functional impairments. Despite decades of research and medical advancements, current treatment options for SCI remain limited, in part due to the complex pathophysiology of spinal cord lesions including cellular transformation and extracellular matrix (ECM) remodeling. Recent studies have increased focus on fibrotic scarring after SCI, and yet much remains unclear about the impact of fibrotic scarring on SCI lesion progression. Here, using collagen and decellularized spinal cord-based composite hydrogels, a three-dimensional (3D) cell culture model mimicking the fibrous core of spinal cord lesions was implemented …

Cover Crop And Wheel-Track Effects On Soil Properties Under Cotton Production In Eastern Arkansas, Shelby G. Lebeau, Kristofor R. Brye, Michael Daniels, Lisa S. Wood

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Repetitive use of heavy farm machinery in cultivated agriculture may cause soil compaction that can adversely affect soil-health-related properties. Cover crops (CC) are well-documented to alleviate problems associated with compaction and improve overall soil health in time. The objective of this field study was to evaluate the cumulative effects of CC treatment (i.e., with ≥ 6 years cereal rye [Secale cereale L.] CC and ≥ 4 years with no cover crop [NCC]) and sample/measurement placement (i.e., in the bed [B] and in the wheel-track [WT] and no-wheel-track [NWT] furrow) on near-surface soil physical-, chemical-, and infiltration-related properties in an …

Near-Surface Soil Chemical Properties As Affected By Cover Crops Over Time In The Lower Mississippi River Valley, Cooper Fanning, Kristofor R. Brye, Michael B. Daniels, Trenton Roberts, Samuel B. Fernandes, Lisa Wood

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Typical row-crop agricultural practices can potentially be harmful to soil health and future sustainability. The use of cover crops (CC) as a mechanism to improve soil health on a wide scale remains underutilized. Soil health remains a major concern for the sustainability of agricultural productivity, therefore, research into CC implementation as a mean to preserve or improve soil health is warranted. The objective of this study was to evaluate the effects of CC on the soils in the eastern Arkansas portion of the Lower Mississippi River Valley (LMRV) over time for various chemical soil parameters, including pH, soil organic matter …

Addressing The Gender Wage Gap For Native American Women, Danielle Digrazia, Ann C. Juliano

Faculty Publications

No abstract provided.

Lawyerless Litigants, Filing Fees, Transaction Costs, And The Federal Courts: Learning From Scales, Judith Resnik, Henry Wu, Jenn Dikler, David T. Wong, Romina Lilollari, Claire Stobb, Elizabeth Beling, Avital Fried, Anna Selbrede, Jack Sollows, Mikael Tessema, Julia Udell

Northwestern University Law Review

Two Latin phrases describing litigants—pro se (for oneself) and in forma pauperis (IFP, as a poor person)—prompt this inquiry into the relationship between self-representation and requests for filing fee waivers. We sketch the governing legal principles for people seeking relief in the federal courts, the sources of income of the federal judiciary, the differing regimes to which Congress has subjected incarcerated and nonincarcerated people filing civil lawsuits, and analyses enabled by SCALES, a newly available database that coded 2016 and 2017 federal court docket sheets. This Essay’s account of what can be learned and of the data gaps demonstrates the …

Appendix D Comparison Of Historical Coc Results To Groundwater Remedial Goals, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final Bpsou Backfill And Cover Material Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2024 Draft Blacktail Creek Remediation And Contaminated Groundwater Hydraulic Control Site Pre-Design Investigation Work Plan, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – Second Quarter 2024, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Cascadia Innovation Corridor: The Role Of Social Entrepreneurship In The Making Of A North American Innovative Cross-Border Region, Kathrine Richardson

Faculty Research, Scholarly, and Creative Activity

There remains a dearth of literature dedicated to urban core-to-core cross-border regions, especially ones described as highly innovative. Hence, there is a growing need to advance the concept of a cross-border region, especially through the lens of clusters and smart system innovation policy by considering what might be the role of social entrepreneurship regarding its development. Thus, this article focuses on how an innovative cross-border region may be emerging between the bi-national Cascadia region, and analyzes the role of corporate driven social entrepreneurship in its advancement.

Changes In Physical Activity And Sleep Following The Covid-19 Pandemic On A University Campus: Perception Versus Reality, Bryce T. Daniels, Samantha Robinson, Ivan Vargas, Jamie I. Baum, Erin K. Howie

Health, Human Performance and Recreation Faculty Publications and Presentations

It has been hypothesized that key lifestyle behaviors of physical activity and sleep worsened in response to the Coronavirus disease (COVID-19) pandemic. However, there have been inconsistencies in findings of changes in these key lifestyle behaviors across populations likely due to the wide variety of assessment methods. The purpose of the study was to compare physical activity and sleep before and after the COVID-19 pandemic using accelerometers and self-reported behaviors. A longitudinal follow-up was conducted on students, faculty, and staff at a university campus in the United States. In the periods before March 2020 (covering the academic years of 2018-2019 …

Exploring An Ai Chatbot To Close School Counselor Information Gaps: A Design Science Approach, Kalee Crandall

Masters Theses & Doctoral Dissertations

Chatbots are an emerging technology that stimulate conversations with humans often using generative artificial intelligence (AI). This technology is becoming increasingly relevant, particularly in the field in school counseling. For school counselors facing growing demands, utilizing data to demonstrate the effectiveness of their services on student outcomes is crucial to secure recent position increases. Historically, school counselors have struggled with the expectation to use data and utilize available technology. AI chatbots have the potential to help school counselors, a traditionally non-technical audience, efficiently evaluate data, create goals, and explore potential interventions to accomplish those goals.

To support school counselors in …

Addressing Transportation Construction Workforce Needs Through Innovative Policies And Practices, Thomas O'Brien, Ben Olson, Devin Martinez-Flores

Mineta Transportation Institute

A 2019 survey conducted by the Associated General Contractors of America, prior to the COVID-19 pandemic, found that construction firms across the country are struggling to fill open positions. Eighty percent of survey respondents indicated they have difficulty filling jobs in occupations that are essential to highway construction. This includes heavy equipment operators, cement masons, and iron workers, among others. This workforce shortage in California will become more problematic as public agencies and their contractors seek to implement projects funded by the Bipartisan Infrastructure Law (BIL), also known as the Infrastructure Investment and Jobs Act (IIJA). In California there are …

A Convenient Synthesis Of Short Α-/Β-Mixed Peptides As Potential Α-Amylase Inhibitors, Naeem Ahmed, Fakhira Razzaq, Muhammad Arfan, Mansour K. Gatasheh, Hammad Nasir, Joham Sarfraz Ali, Hamna Hafeez

Michigan Tech Publications

Over the last decades, the increased incidence of metabolic disorders, such as type two diabetes and obesity, has motivated researchers to investigate new enzyme inhibitors. Inhibition of the α-amylase enzyme is one therapeutic approach in lowering glucose levels in the blood to manage diabetes mellitus. The objective of this study was to synthesize short α-/β-mixed peptides in the solution phase. The Boc-protected α-L-leucine was converted to β-analogue by using Arndt–Eistert synthesis with the advantage of no racemization and retention of configuration. Three novel short peptides were successfully synthesized: N(Boc)-Gly-β-Leu–OCH3(14), N(Boc)-O(Bz)α-Ser-β-Leu–OCH3(16), and N(Boc)-O(Bz)-α-Tyr-α-Gly-β-Leu–OCH3(17), characterized by FTIR and 1H NMR analysis. The …

Editorial Commentary On The Special Issue “Antioxidant Therapy For Cardiovascular Diseases”—Cutting-Edge Insights Into Oxidative Stress And Antioxidant Therapy In Cardiovascular Health, Guim Kwon, K. Michael Gibson, Lanrong Bi

Michigan Tech Publications

No abstract provided.

Cease The Alarms - A Nurse-Led Bundled Approach To Alarm Management, Annie Tolliver

EBP Fellowship

No abstract provided.

Change In Expectations: A Policy Recommendation For Future And Current Nurse Educators, Kylateia Farrar-Stern, Amber Young-Brice

College of Nursing Faculty Research and Publications

Currently, there are no standardized requirements for pedagogical preparation for nurse educators at the state and national level. Various stakeholders have identified an issue in the preparation of nurse educators in academia. Current recommendations are that faculty have a master's or doctoral degree in nursing (American Association of Colleges of Nursing, 2017); however, requirements do not include educational preparation prior to or concurrent with starting a faculty position. This policy paper highlights a recommendation to require one of the following: the Certified Nurse Educator credential or certificate in teaching for educators without prior formal education in pedagogy. Outcomes of such …

Resting-State Eeg Microstate Features For Major Depressive Disorder Classification, George M. V. Quinn

Dissertations, Theses, and Capstone Projects

Neuroimaging studies have revealed consistent abnormalities in functional connectivity within specific neural networks that may serve as biomarkers for major depressive disorder (MDD). It is important to find inexpensive, non-invasive techniques that target these biomarkers to make diagnosis easier and more objective. EEG microstates are quasi-stable potential topographies that are thought to reflect the quasi-stable network activity of the underlying neural generators. MDD has been shown to alter features of the four canonical EEG microstates (A, B, C, D) with some conflicting results. The most consistent network abnormalities in MDD are found in the anterior default mode network, and this …

Trends And Predictors Of Internet Use For Health-Related Purposes Among Adults In The United States Of America, Paul Ayamah

Dissertations, Theses, and Capstone Projects

This longitudinal study draws on data from the Computer and Internet Use Supplement (CIUS) of the Current Population Survey (CPS) across 2015, 2017, 2019, and 2021 and examines three domains of internet use for health-related purposes: seeking health information online, communicating with healthcare providers via digital platforms, and using electronic health monitoring devices to monitor and transmit health data. The study reveals a 10.60% increase in health-related internet use between 2015 and 2021 among all respondents. Communication with healthcare providers online increased from 21.71% in 2015 to 27.7% in 2021 (p < 0.001), while the use of electronic devices to monitor and transmit health data recorded the least growth of 3.15% in 2014 to 5.93% in 2021 (p < 0.001). Patient communication with a health service provider over the internet demonstrates the most significant increase of 3.74%. Furthermore, this study uncovers disparities between internet use among younger (aged 18-39) and older (aged 75 and older) adults, in which young adults were more likely to seek health information online. From the multivariable logistic regression, factors most likely to contribute to online information seeking include: higher educational attainment, access to multiple digital devices, and access to multiple internet sources.

The study highlights persistent digital divides, particularly among older …

Exploiting The Heavy Chain Glycans For The Improvement Of Radioimmunoconjugates, Cindy Rodriguez

Dissertations, Theses, and Capstone Projects

Radiolabeled antibodies have become indispensable tools in nuclear medicine. However, the natural roles of antibodies within the immune system mean that they have several intrinsic limitations as a platform for radiopharmaceuticals. A handful of recent preclinical studies suggest that binding by FcR and particularly FcyRI can affect the pharmacokinetic profiles of 89Zr-labeled radioimmunoconjugates. Fc receptors (FcR) are responsible for many of the interactions between immunoglobulins (IgG) and immune cells. In biomedicine, this interplay is critical to the activity of several types of immunotherapeutics; however, relatively little is known about how FcRs affect the in vivo performance of radiolabeled antibodies. Antibodies …

Assessing The Influence Of Llms On Online Review: Identifying And Addressing The Rise Of Convincing Fake Reviews, Zico Abhi Dey

Dissertations, Theses, and Capstone Projects

Large Language Models (LLMs) have made remarkable advancements, reaching a level where they can generate outputs that compete with human writing. LLM's sophisticated features, however, make it hard for us to spot the difference between human-written and AI-generated text. LLMs have several weaknesses since they are susceptible to hallucinations and outputting factually incorrect information. Additionally, they may be used maliciously to promote deception and instigate fraud, such as fake reviews generation, which rapidly appear on the internet while posing a challenge for consumers who want to place their faith in online reviews. To maintain trust in the online information system, …

Guardians Of The Bacterial Genome: Mechanistic Insights Of The Ner Atpase Uvra With Damaged Dnas; Molecular Interactions Between The V.Cholerae Initiator Rctb With Cognate Oricii Dna, Devon Semoy

Dissertations, Theses, and Capstone Projects

Nucleotide excision repair (NER) is one of the fundamental DNA repair pathways in all organisms. A unique facet of NER is the large set of DNA lesions the pathway is capable of repairing (Truglio, Croteau, et al. 2006). The NER proteins may thus be responding to global features of native DNA such as changes in thermodynamic stability, geometry and kinetic properties (Maillard et al. 2007). In this study we set out to investigate the first and primary responder to NER in bacteria, UvrA (Kraithong et al. 2021). UvrA is a homo-dimeric ABC ATPase; proteins that are known to transduce the …

Complicity, Eliana Luxemburg-Peck

Dissertations, Theses, and Capstone Projects

What does it mean to be complicit in diffuse collective wrongs like structural racism, gender-based oppression, or environmental damage, and what responsibilities are entailed by complicity? Moral philosophers have often understood complicity to consist in some degree of inherited culpability, arising from knowing or intentional contributions to the bad acts of a primary wrongdoer. But these theories fail to explain complicity in the foregoing contexts, and cannot justify needed efforts to hold individuals accountable for unwitting contributions to systemic wrongs and injustices. In response to this gap, my dissertation defends a novel reconceptualization of complicity as participation in collectively perpetrated …

The Blackgirl Project: Examining The Impact And Manifestation Of Colorism Among Black Adolescent Girls In The United States: A Critical Participatory Action Research Approach, Gina (Diagou) R. Sissoko

Dissertations, Theses, and Capstone Projects

Colorism is a skin tone stratification system that privileges lighter-skinned people over their darker-skinned counterparts. Although colorism remains surprisingly understudied, it has been linked to a variety of negative mental health and social outcomes. Colorism particularly impacts Black girls—particularly in adolescence. This dissertation utilized microaggressions theory and a critical participatory action research framework to describe (1) the manifestation of colorism in the lives of darker-skinned Black girls, (2) the impact of colorism on Black girls’ mental health, (3) the ways in which Black girls cope with and resist colorist experiences, and (4) create a taxonomy of colorist microaggressions. Ten Black …

Helpful Intentions? Impact Of Intentionality On Children's Memory For Forensically-Relevant Information, Ella P. Merriwether

Dissertations, Theses, and Capstone Projects

Rationale: When a child is a witness or victim of a crime, they are often asked a barrage of questions regarding when the crime took place, how many times it occurred, and how the abuse unfolded (Cross & Whitcomb, 2017; Sullivan et al., 2022). These questions can be problematic because they rely on concepts for which children may lack memory or linguistic ability to answer (Fenson et al., 2000; Friedman, 1993). One fundamental element missing from the copious research (e.g., Brubacher et al., 2012; Stolzenberg et al., 2017a; Wylie et al., 2021) on children’s ability to recount forensically-relevant information is …

Claiming The Right To Belong: Diversity And The Politics Of Inclusion In Queens, New York, Susan J. Tanenbaum

Dissertations, Theses, and Capstone Projects

This dissertation examines social integration in a diverse civic and political mainstream. The social science research on intergroup contact in U.S. cities undergoing significant demographic change tends to focus on encounters between members of majority “in-groups” and minority “out-groups” in the context of workplaces, neighborhoods, and families. I contend that civic politics is another compelling strategic site for observing intergroup contact between emerging and established players. My study presents three cases of claims-making activity during the post-9/11 period in New York City’s borough of Queens, where close to 50% of the population is foreign-born and no single racial group predominates. …

Late-Life Depression: The Interplay Between Cerebrovascular Risk, Cortical And Subcortical Atrophy, And Treatment Response, Dakota Egglefield

Dissertations, Theses, and Capstone Projects

Late-life depression (LLD) is associated with poor response to antidepressant medication treatment, cognitive impairment, cerebrovascular disease, and brain changes both in white and gray matter. Of particular interest is the vascular subtype of LLD, vascular depression (VD). Although LLD and VD have received considerable research attention, there are still areas that must be further clarified to adequately characterize aspects of LLD and VD that provide valuable information for possible interventions. Such areas include a stronger understanding of the moderating role of brain atrophy and changes in cognition in treatment response in LLD. This dissertation consists of three separate studies aimed …

Loneliness And The Urban American (Non-)Romantic, Sarah C. Cook

Dissertations, Theses, and Capstone Projects

Loneliness, also known as ‘perceived social isolation,’ is an increasingly common feeling among Americans. It can be critically unhealthy when chronic, and recent revelations about its health effects have garnered a significant amount of media attention. Although statistical evidence tells us that marriage is the strongest defense against loneliness, over a third of Millennials and Gen-Zers say marriage is outdated; and census data shows that living alone is both one of the fastest-growing demographics in America, as well as a relatively stable housing arrangement. After examining existing research and media reports on loneliness itself in some depth, including factors that …