Digital Commons Network^™

In-Use Stability And Device Compatibility Define Clinically Actionable Handling Limits For A Gmp-Produced Attenuated Listeria Monocytogenes Vaccine Expressing Gucy2c, Jagmohan Singh, Taranjot Johar, Vannessa Scully, Scott A. Waldman, Babar Bashir, Adam E. Snook

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Background: Live-attenuated Listeria monocytogenes (Lm) vectors are a clinically validated cancer immunotherapy platform, but translation requires reproducible, clinically realistic workflows for dose preparation and infusion. For live bacterial products, in-use stability and device compatibility can drive dose variability through adsorption, settling, and device losses. Methods: We developed and GMP-manufactured an attenuated Lm vaccine expressing human GUCY2C (Lm-GUCY2C) and performed translational characterization, including construct verification and immunogenicity readouts, and defined the administration-focused in-use stability and device compatibility. Post-thaw stability was assessed in primary cryovials and during preparation and delivery from 250 mL saline infusion bags using standard clinical devices (syringes/needles, filter-free …

Defining Civil Rico's "Inquiry To Business Or Property" Requirement: The Supreme Court Takes A Few Steps, Says It Punts, But Actually Fumbles, Randy D. Gordon

Penn State Law Review (2003 - Present)

No abstract provided.

The Fcc Is Not A Rubber Stamp: Preserving Democratic Accountability In The Universal Service Fund Through Agency Independence, Desirae N. Satterlee

Penn State Law Review (2003 - Present)

No abstract provided.

The Objective Reasonableness Of Employee Reporting: An Analysis Of The Circuit Split Regarding The Whistleblower Provision Of The Sarbanes-Oxley Act, Madison E. Steinmann

Penn State Law Review (2003 - Present)

No abstract provided.

Using The Socio-Ecological Model To Explore Parents' Resilience And Perceptions Of Adverse Childhood Experiences: A Qualitative Study In The Southeastern United States, Maribel G Dominguez, Christine Markham, Andrew E Springer, Louis D Brown

Faculty, Staff and Student Publications

Background: The negative impact of adverse childhood experiences (ACEs) on child development is documented. The parent-child relationship protects against ACEs and improves healthy child development, playing a crucial role in preventing and mitigating ACEs by strengthening parental resilience. However, there is a gap in the literature on our understanding of parental resilience's impact on the parent-child relationship within the social-ecological model (SEM) (i.e., intra- and interpersonal, community, and societal levels). Objective: This study explores parents' perspectives on parental resilience as a protective factor for preventing and mitigating ACEs at every level of the SEM. Method: This study uses a thematic …

The Minutes Of The Marshall University Staff Council Meeting, May 2026, Marshall University Staff Council

Staff Council Minutes

No abstract provided.

A Soft Diet Attenuates Exercise-Induced Increases In Cortical Bone Density And Formation In Long Bones In Growing Mice, Yasuhiro Shimizu, Fatma Rashed, Huan Cao, Yuki Arai, Takashi Ono, Kazuhiro Aoki

Faculty, Staff and Student Publications

Bone and muscle are closely linked through functional interdependence. Training and regular exercise can improve and maintain optimal bone mass and strength. Here, we investigated the effects of exercise combined with soft versus hard diet (pellet) on long bones in mice. Four groups of male C57BL/6J mice (n = 5 per group) were studied: hard diet (pellet) with exercise, soft diet (powdered) with exercise, hard diet (pellet) without exercise, and soft diet (powdered) without exercise. Femur and tibia were analyzed using radiographic, micro-CT, and histomorphometric techniques. Exercise combined with a hard diet significantly increased cortical bone density, mineral apposition rate, …

In Silico Molecular Docking Study Of Antidiabetic Bioactive Compounds From Brotowali (Tinospora Cordifolia) Targeting Glut4 In Type Ii Diabetes Mellitus, Gita Euaggelion Tarigan, Surya Dwira

Indonesian Journal of Medical Chemistry and Bioinformatics

Type 2 diabetes mellitus (T2DM) is a global metabolic disorder characterized by insulin resistance and impaired glucose uptake. Despite the availability of pharmacological therapies, limitations such as adverse effects and high costs highlight the need for alternative therapeutic candidates. Tinospora cordifolia has been widely reported to contain bioactive compounds with antidiabetic potential; however, comparative evaluation of their interaction with glucose transporter type 4 (GLUT4) remains limited.

This study aimed to identify the most promising bioactive compounds from Tinospora cordifolia targeting GLUT4 using an in silico molecular docking approach, followed by pharmacokinetic and toxicity (ADMET) prediction. Molecular docking was performed using …

Maurice Robinson V. The State Of Nevada, 142 Nev. Op. 37 (May 21, 2026), Kaleigh Evanchak

Nevada Supreme Court Summaries

Elder exploitation is charged as one unit per victim, and certain theft offenses may be aggregated when committed as part of a scheme or continuing course of conduct.

Paternal Investment And Labor Market Soft Skills: Evidence From The Philippines, Timothy Crane Wilkins

Master's Theses

Fathers’ involvement in their children’s lives may shape the social skills that determine labor market success, yet evidence from Southeast Asia remains limited. This study examines the relationship between paternal investment and soft skills used in the workforce. Using original survey and experimental data from more than 300 parents of young children in Metro Manila, Philippines, I analyze how their fathers’ past involvement during childhood, and current involvement as grandparents in childcare relate to dictator-game giving, interpersonal trust, and workplace relations. The results indicate that paternal investment is most statistically significant with improved workplace relations, specifically with participants’ reported ability …

Hiv/Aids-Related Awareness And Misconceptions Among Grade 10 Students In Muttrah Wilayat, Muscat, Oman: A Descriptive, Cross-Sectional Study, Rahma Abdullah Al Riyami, Balqees Ahmed Al -Maawali, Nabila Hamood Al Wahaibi, Mariam Rashid Al Rashdi, Fatma Ahmed Al Hinai

Sultan Qaboos University Medical Journal

Objectives: Despite Oman having a low HIV prevalence, stigma and lack of knowledge among young people may hinder prevention efforts. This study aimed to assess HIV/AIDS-related knowledge and misconceptions among Grade 10 students in Muttrah wilayat in Oman. Methods: This cross-sectional study was conducted in February 2025 and included Grade 10 students from 4 governmental schools in Muttrah selected via proportional stratified sampling. The sample size was calculated depending on the number of students in Grade 10. Data collection was performed during face-to-face interviews using a validated Arabic-language questionnaire. Results: A total of 271 Grade 10 students were included in …

29-28 41st Ave. Owner Llc V. Parzinger Design Inc.

All Decisions

In this nonpayment proceeding, the court denied the tenant's motion for summary judgment and granted the landlord's cross-motion to amend its petition. The tenant argued the landlord could not recover arrears under expired leases per RPAPL § 711(2) and that the predicate Good Cause Eviction Law (GCEL) notice was defective. The court held that arrears under prior leases are recoverable if the landlord-tenant relationship was not severed, as renewals extend the existing tenancy. The court also ruled that a defective GCEL notice is a ministerial error, amendable, and not fatal to a nonpayment proceeding, as it does not prejudice the …

140 E 35th St. Llc V. Booker

All Decisions

The Civil Court denied tenant's motion to dismiss for landlord's failure to comply with LLC publication requirements under LLCL § 206 at commencement. The court held that noncompliance is not a jurisdictional defect and that subsequent publication warrants nunc pro tunc application, analogizing to the MDL § 325 registration requirement. Because landlord had begun publication and filing with the Department of State, the proceeding was permitted to continue.

Wong V. Pierre

All Decisions

In this small claims action by a former tenant for return of their security deposit, the court finds the landlord did not demonstrate that the tenant caused damage to the apartment and orders return of the full deposit amount.

Cultivating Healing: Understanding Pinay Adolescent Social And Emotional Well-Being, Dylan R. Francisco

Doctoral Dissertations

The Filipina/x/o American community is the third largest Asian American ethnic community in the United States (U.S. Department of Commerce, 2023). Among the population, adolescents in particular have been identified as being in a pivotal period, as adolescence in the Asian American community marks the unfolding of identity development, in addition to increasing familial and societal pressures (Choi et al., 2018).  Existing research has identified Filipina/x/o American adolescents in particular to have higher rates of smoking, alcohol use, teen births, depressive rates, and thoughts about suicide. Despite these growing concerns, limited studies have been conducted on this specific ethnic community …

The Current Status Of Utah Women & Girls: A Research Synopsis: 2026, Susan R. Madsen, Corinne Clarkson

Marketing and Strategy Faculty Publications

In 2025, U.S. News and World Report rated each state using 71 metrics across eight categories. Utah was rated the #1 “Best State Overall” for the third year in a row, ranking first in fiscal responsibility and third in both the economy and infrastructure categories and fourth in education.¹ Utah was also ranked number one for “Economic Outlook” by Rich States, Poor States in 2025, a forward-looking forecast that is based on 15 state policy variables.² WalletHub ranked Utah as the second “Most Charitable State” and the number one state for volunteering and service.³ In addition, ConsumerAffairs …

Diagnosing Autism In Children Using An Advanced Deep Learning Model, Hadeel M. Saleh, Yasir Khalaf Rashid, Noor Raji Mohammed, Taisir Abdulrazzaq Jar Alisawi, Saif Mohanad Kadhim, Muhammad Majid Taha Al-Ani, Tayseer Omar Hindy

Mesopotamian Journal of Computer Science

Autism Spectrum Disorder (ASD) represents a complex neurological disorder characterized by difficulties in social engagement communication and repetitive behaviors. Identifying and intervening as soon as possible will result in improving the quality of life among children diagnosed with autism .In this study strives to provide lifestyle based relatively simple, practical and most importantly accurate deep learning autism diagnosis model of differential diagnosis of autism among children. Multiple deep-learning architectures such as deep neural networks (DNNs) were trained and compared. The proposed model attained outstanding performance, as reflected by the 100% classification ability of the model in the research results. We …

The Perijunctional Zone Is A Molecularly Distinct Muscle Subdomain Altered In Duchenne Muscular Dystrophy, Seth G Haddix, Chuansheng Zhang, Yanhong Liu, Juan Oses-Prieto, Alma L Burlingame, Matthew N Rasband

Faculty, Staff and Students Publications

The neuromuscular junction (NMJ) is a well-established model for synapse development, structure, and function. Surrounding the NMJ is a narrow perijunctional zone (PJZ), enriched in muscle-specific voltage-gated sodium channels that prevent synaptic fatigue. Despite this role, the PJZ remains poorly characterized. To determine its molecular composition, we engineered mice to express the biotin ligase TurboID fused to the cell adhesion molecule neurofascin (Nfasc), and that localizes to the PJZ through ankyrin scaffolding proteins. Using proximity proteomics, we identify numerous PJZ-associated proteins, including Perilipin 4 (Plin4), that are highly enriched and clustered at the PJZ. We also perform proximity proteomics on …

Circulating Metabolites Associated With Protection Against Mycobacterium Tuberculosis Infection And Inhibition Of Mycobacterial Growth, Todia P Setiabudiawan, Lika Apriani, Julian Avila-Pacheco, Edwin Ardiansyah, Vinod Kumar, Bachti Alisjahbana, Ayesha J Verrall, Andrew R Dinardo, Agnes R Indrati, Vera P Mourits, L Charlotte J De Bree, Simone J C F M Moorlag, Clary B Clish, Leo A B Joosten, Arjan Van Laarhoven, Krista E Van Meijgaarden, Mihai G Netea, Simone A Joosten, Valerie A C M Koeken, Philip C Hill, Reinout Van Crevel

Faculty, Staff and Students Publications

A significant proportion of individuals who are heavily exposed to infectious tuberculosis patients do not acquire Mycobacterium tuberculosis (Mtb) infection, as detected by an interferon gamma release assay (IGRA). We examined circulating metabolite profiles and metabolic genotypes in 199 heavily exposed IGRA-negative tuberculosis household contacts in Indonesia. Based on differentially abundant metabolites, activity of several pathways including arachidonic acid, arginine and proline, glutathione, and tryptophan metabolism, correlated with a negative IGRA at three months. SNPs near PRODH (involved in arginine and proline metabolism) were associated with circulating proline concentrations and persistently negative IGRA results, while SNPstudys near AFMID (involved in …

Childcare Challenges Among Surgical Trainees And Faculty: A Single-Institution Study, Emma G Burke, Sarah Peiffer, Melissa Koci, Lindsay Dean, Kristy L Rialon, Michele Loor, Alice King

Faculty, Staff and Students Publications

Background: Previous studies have demonstrated the challenges of parenthood in surgical training and careers. However, certain aspects of childrearing for surgeons remain understudied. We aim to leftacterize the complexity and costs of childcare amongst surgical trainees and faculty.

Methods: An anonymous, self-administered survey was conducted within the Department of Surgery at a large academic medical center. Both male and female trainees and faculty were included in the analysis. Chi-square or Fisher's Exact test was performed.

Results: Forty-six respondents provided information about childcare costs, with 37% of respondents being residents or fellows. Trainees worked longer workhours (p = 0.003) than their …

Building A Hurricane Katrina Archive: Preserving History On A Health Sciences Campus, Chandler D. Smith, Elizabeth H. Holt, Jennifer K. Lloyd

Library Faculty Publications

Background: Our library started discussing the creation of an archive of materials in late 2023. We decided on a multifaceted approach. We would conduct oral histories with individuals who were either employed or attending classes in the fall of 2005. We would attempt to discover photographs and videos, and search for documents from that time.

Additionally, we wanted to keep the traumatic nature of the event in mind as we created the archive. The first step was creating a mission statement and a collection policy that both reflected our goals for the collection but also reflected sensitivity to all those …

Mapping The Impact Of Hurricane Katrina On The Health Sciences Literature: A Scoping Review Pilot Project, Elizabeth H. Holt, Sharon Duffy, Matthew Folse, Rowan Marye, Chandler D. Smith

Library Faculty Publications

Background: In recognition of the 20th anniversary of Hurricane Katrina, the Louisiana State University Health Sciences Center - New Orleans (LSUHSC-NO) Libraries created a digital archive commemorating the event. Included in the archive is a bibliography of literature published by LSUHSC-NO affiliated authors about the storm and its aftermath. That collection of articles now serves as the pilot for a scoping review of literature by authors beyond LSUHSC-NO. The goal is to identify and map the existing health sciences literature related to Hurricane Katrina and the failure of the federal levee system, and its impact both immediate and long term …

Pemanfaatan Pengetahuan Tradisional Indonesia Berdasarkan Potensi Daerah Sebagai Modal Pembangunan, Heri Aryanto

Jurnal Hukum & Pembangunan

Abstract

Pemanfaatan Pengetahuan Tradisional Indonesia Berdasarkan Potensi Daerah Sebagai Modal Pembangunan, Heri Aryatno

Jurnal Hukum & Pembangunan

Abstract

Can We Digitize A Soul? A Study Of Ai And Ethics, Spirituality, And Humanity, Debra S. Espinor, W. Scot Headley, Linda Samek

International Christian Community of Teacher Educators Journal

The rapid advancement of computing technologies and artificial intelligence (AI) is fundamentally reshaping both society and the educational landscape. This study examines faculty experiences and attitudes toward the role of AI in teaching and research within the distinct context of Christian higher education. While recognizing the potential of AI to drive educational innovation, this research also addresses significant faculty concerns regarding the implications for academic integrity, critical thinking, and intellectual property. Specifically, the study investigates faculty perspectives on data security and privacy, the reproduction of creative expression in art and music, and the broader impact of AI on the liberal …

Teacher Identity Formation In A Christian University: Expectations And Experiences, Heather J. S. Birch

International Christian Community of Teacher Educators Journal

This qualitative phenomenological study examines the alignment between applicants’ expectations and graduating candidates’ lived experiences in a teacher education program at a Christian university. Drawing on data from 166 participants collected during application interviews and final capstone conversations, the research explores how candidates anticipated and later reflected on the program’s faith integration, community, and professional formation. Findings reveal that most candidates’ expectations were met or exceeded, highlighting three key shifts: faith experienced as lived values within an inclusive community; unexpected depth of relational support from faculty and peers; and meaningful professional and personal growth rooted in the faith-explicit context. The …

An Editorial: If I Should Fall, Patrick Otto, David Weir

International Christian Community of Teacher Educators Journal

Abstract

The future of Christian higher education will be determined by whether today’s leaders can identify and train successors who are called to the mission and vision of each institution. The task of transitioning to a new generation of leaders has become more complicated as research shows that the church in America is in decline. The increased use of adjuncts adds to the dilemma because it takes time and a single-minded focus to prepare high-level leaders.

We are at a critical time finding the right people to replace the Baby Boomer generation, which has led well past retirement age. As …

Your Voice Matters: Get Involved With Gsc, Casey Johnson-Pasqua, Rebecca Rydstrom

Staff Professional Development Week

Alumni Relations’ Rebecca Rydstrom and Youth Programs’ Casey Johnson-Pasqua, GSC’s Governance and Elections committee reps, will lead this session, which will focus on how staff can turn ideas into action by getting involved with the Gallaudet Staff Council (GSC). We’ll share what GSC does, what being a representative looks like, and how staff can step into these roles to help shape our campus community.

Actions In Brief Of The Board Of Directors January 16-18, 2014

Virginia Dental Journal

No abstract provided.

Creating Happiness As A Practice Protocol, Oliva Mcleod Straine

Virginia Dental Journal

No abstract provided.