Digital Commons Network^™

Full-Body Ai Agent: A Perspective On Multi-Scale Collaborative Ai For Systemic Biology And Precision Medicine., Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou

Faculty, Staff and Student Publications

Artificial intelligence (AI) is increasingly applied to biomedical research, but most current systems remain limited to specific tasks, data types, or biological scales. This makes it difficult to connect molecular alterations, organelle dysfunction, cellular behavior, tissue remodeling, organ physiology, systemic regulation, and whole-body phenotypes into coherent biological reasoning. In this Perspective, we propose the Full-Body AI Agent as a hypothetical multi-agent framework and conceptual blueprint for future systemic biology and precision medicine, rather than a fully implemented software platform. This framework envisions a supervisory Full-Body AI Agent coordinating seven biological-level agents, namely Molecule, Organelle, Cell, Tissue, Organ, Organ System, and …

Content Matters, Context Matters: Unraveling Behavior Dynamics In An Online Health Community For Tobacco Cessation, Tavleen Singh, Runzhi Zhou, Kayo Fujimoto, Sahiti Myneni

Faculty, Staff and Student Publications

Objectives: The objective of this research was to examine the content and context-specific information diffusion patterns underlying communication pertaining to tobacco use from online health communities (OHCs).

Materials and methods: We utilized a mixed-methods approach comprising multidimensional qualitative coding to identify themes and communication attributes, automated text analysis leveraging advances in large language models (LLMs) to classify message content and context, and social network analysis to examine the dynamics of peer interactions in this study. Using QuitNet, an online tobacco cessation forum (n = 64 632 members, n = 2.39 million forum messages spanning 2000-2015), we extracted message-level features …

Anti-Egfr Liposomal Drug Delivery System Loaded With Agy2 Potentiates The Anti-Cancer Effect Of Agy2 Against Egfr Expressed Pancreatic Cancer, Raviteja Bulusu, Esther Frimpong, Joy Okoro, Sunil Krishnan, Saunjoo Yoon, Bo Han, Xue Zhu, Edward Agyare

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide due to late diagnosis, dense stromal barriers, and resistance to existing chemotherapeutics. To address these limitations, we developed a targeted liposomal delivery system that encapsulates AGY2, a newly synthesized, more potent fluoro pyrimidine nucleoside analog. In this study, epidermal growth factor receptor (EGFR) functionalized liposomal nanoparticles (EGFR-AGY2 LNPs) were optimized using Box–Behnken Design to achieve superior physicochemical stability. The optimized formulation demonstrated nanoscale dimensions (∼121 nm), high entrapment efficiency (∼75%), and strong colloidal stability. Surface antibody conjugation was confirmed by Fourier Transform Infrared Analysis (FTIR) and immunofluorescence analysis, …

Practice Patterns In Pediatric Cardiothoracic Presurgical Conferences: A Multicenter Survey Study, Britney Reed, Poonam Puranik, Andrew Rodenbarger, Mira Trivedi, Dilachew A Adebo, Gary Beasley, Louis Bezold, M Jay Campbell, Michael R Carr, Joshua Daily, Mark Debrunner, Erica Del Grippo, Carlen G Fifer, Timothy M Hoffman, Susan R Hupp, Joshua D Kurtz, Gira Morchi, Carl Owada, Renuka Peterson, Michael D Puchalski, Ryan A Romans, Arwa Saidi, Rajesh U Shenoy, Anoop K Singh, Robert D Tunks, Thomas M Yohannan, Carolyn M Wilhelm, Jyoti K Patel

Faculty, Staff and Student Publications

Pediatric cardiothoracic surgeries are high-stakes, complex procedures, typically undergoing prior review at multidisciplinary conferences. This study evaluates practice patterns of conferences throughout the United States (US). Surveys were distributed to fellowship program directors or division directors in 124 US pediatric cardiology centers seeking information on conference logistics, fellow roles, quality improvement (QI), and satisfaction. All 47 responding centers (response rate 38%) conduct presurgical conferences, mostly on a weekly basis (92%) lasting 60-120 min (79%). The conferences are solely virtual (19%) or hybrid (81%). High-volume centers (> 300 surgical cases/year) are more likely to hold multiple conferences (13/20 vs 7/27, p <  0.01) and less likely to designate a moderator (11/20 vs 22/26, p = 0.027). Categorical pediatric cardiology fellows at 33 centers present clinical data (97%), echocardiograms (85%), catheterizations (82%), and cross-sectional imaging (39%), typically beginning in their first year. Most centers report that minor (98%) or major changes (51%) are made to patient management at least "sometimes." Responders rate conferences as very important (median 10/10 on a 10-point Likert scale, IQR 9-10), but satisfaction is more modest (median 7/10, IQR 7-9). Only 17% of centers have a formal QI process. Comments from 42 centers reveal positive themes of collaboration (68%) but also concerns about lengthy (30%) or inefficient (36%) discussion. Conclusions: This survey highlights common practices for pediatric cardiothoracic presurgical conferences. Conferences are collaborative and seen as highly impactful. However, satisfaction varies, and QI efforts are infrequent. These findings highlight opportunities for process improvement and standardization.

Ldm-Morph: Latent Diffusion Model Guided Deformable Image Registration, Jiong Wu, Tinsu Pan, Kuang Gong

Faculty, Staff and Student Publications

Deformable image registration plays an essential role in various medical image tasks. Existing deep learning-based deformable registration frameworks primarily utilize convolutional neural networks (CNNs) or Transformers to learn features to predict the deformations. However, the lack of semantic information in the learned features limits the registration performance. Furthermore, the similarity metric of the loss function is often evaluated only in the pixel space, which ignores the matching of high-level anatomical features and can lead to deformation folding. To address these issues, in this work, we proposed LDM-Morph, an unsupervised deformable registration algorithm for medical image registration. LDM-Morph integrated features extracted …

The International Glossary On Infertility And Fertility Care, 2025†., Fernando Zegers-Hochschild, Silke Dyer, G David Adamson, Valerie Baker, Kurt Barnhart, Siladitya Bhattacharya, Clare Boothroyd, Georgina Chambers, Jacques De Mouzon, Eman Elgindy, Bart Fauser, Karin Hammarberg, Marcos Horton, Osamu Ishihara, Seung Chik Jwa, Mohamed Khrouf, Markus Kupka, Dolores J. Lamb, Martha Luna, A Gustavo Martinez, Brent Monseur, Peter Nagy, Anja Pinborg, Catherine Racowsky, Laura Rienzi, Peter Schlegel, Lone Schmidt, Lan Ngoc Vuong, Tari Turner, Mónica Hebe Vázquez-Levin, Ibrahim Wada, Dagan Wells, Christine Wyns

Manuscripts, Articles, Book Chapters and Other Papers

STUDY QUESTION: What updates of the International Glossary on Infertility and Fertility Care are required, to reflect contemporary scientific knowledge, social needs, and inclusive definitions, while harmonizing international communication across clinical, research, policy, and public domains?

SUMMARY ANSWER: This 4th edition presents 348 consensus-based terms and definitions, including numerous revisions from the previous edition and 79 newly introduced definitions reflecting advances in reproductive science, technology, and evolving social contexts.

WHAT IS KNOWN ALREADY: Previous glossary editions (2006, 2009, 2017) established internationally recognized definitions related to clinical practice, research, and policy. The 2017 edition comprised 283 terms and, among many others, …

Parent Perspectives On Neonatal Research Without Prior Consent: A Mixed-Methods Interview Study., Stephanie A. Kraft, Abigail Brickler, Abril Beretta, Rishabh Jain, Andrea Kelsh, Kaashif A. Ahmad, Justin T. Clapp, Neal W. Dickert, Rebecca A. Dorner, Katherine F. Guttmann, Anup C. Katheria, Stephanie Kukora, Benjamin A. Mooso, Elliott Mark Weiss, Fam-Connect Collaborative

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Recruitment for clinical research in the neonatal intensive care unit (NICU) is difficult, which may lead to low enrollment rates, systematically skewed samples, and nongeneralizable results. Research without prior consent (RWPC), defined as obtaining consent only after infants have been randomized to a treatment arm, may improve enrollment but raises ethical challenges. There is a need to better understand how parents with lived experience of having an infant in the NICU consider RWPC’s impact on critical ethical values related to informed consent, including decision-making, respect, and trust. This mixed-methods study aimed to describe parental perceptions of the acceptability and …

Triple Tracer Heterogeneity In Dual Neoplasia: The "Three Musketeers" In Discerning Squamous Cell Carcinoma And Paraganglioma In The Same Patient, Shyam Kumar Ravada, Gaurav Malhotra, Aaditya Daga, Anurag R Lila, Saba Memon, Tushar Bandgar

Faculty, Staff and Student Publications

Head and neck squamous cell carcinoma of unknown primary (HNSCCUP) comprises 2%-5% of head and neck squamous cell cancers (HNSCC). Its coexistence with abdominal paraganglioma is exceedingly rare. We report a unique case of a 48-year-old male with HNSCCUP presenting as cervical lymphadenopathy and a coexisting abdominal paraganglioma. 18 F-FDG showed uptake in both lesions, while 68 Ga-DOTATATE was avid only in paraganglioma, and 68 Ga-DOTA-FAPI-04 was avid only in cervical nodes. These differential uptake patterns reflect distinct tumor biology and underscore the potential for tailoring theranostic treatment strategies with 177 Lu/ 90 Y isotopes for FAPI-avid squamous cell cancers …

Oxytocin Dynamics And Synchrony In Mother-Child Dyads: Long-Term Neuroendocrine Effects Of Maternal Institutionalization, Olga V Burenkova, Ekaterina M Shurdova, Victoria Manasevich, Marina Norkina, Polina E Pashkina, Aleksei A Podturkin, Alena Vodneva, Marina A Zhukova, Elena L Grigorenko

Faculty, Staff and Student Publications

Early institutional care (IC; orphanage) is a severe form of early psychosocial deprivation with documented long-term effects on social and caregiving functioning. Despite longstanding interest in oxytocin (OT) as a key neuroendocrine modulator of affiliative behavior and stress, OT dynamics and synchrony during mother-child interaction among mothers with IC history remain poorly understood. To our knowledge, this is the first study to characterize maternal and child OT responses and dyadic OT covariation in this population. We measured salivary OT in mothers with IC history and mothers raised in biological family care (BFC), and in their children, at baseline and after …

Creating A Framework For Quantifying Wildland Urban Interface (Wui) Fire Vulnerability Factors, Ryan L. Delalio

Construction Management

Wildfires have been the focus of geospatial research for decades. Climate change and increased suburban development in California are leading to an increase of Wildland Urban Interface (WUI). These zones are at higher wildfire risk, and a metric is needed to determine the most vulnerable communities to help them assess their personal wildfire risk. By analyzing current WUI wildfire vulnerability literature, the main contributing factors behind the impact of wildfires in California emerge. These factors are then paired with datasets that contain geospatial information about the factors to help us find the locations of highest vulnerability. This paper serves as …

Restoreband: An Electromyography Band For Tracking Forearm Muscle Action And Activation In Post-Stroke Adults, Mairin T. Mullen, Melody Nwagwu, Kosuke Nishimura, Benjamin Miramon

Biomedical Engineering

This study involves the design of a non-invasive surface electromyography (EMG) band to estimate hand posture for individuals recovering from stroke and other neuromuscular disorders. The device is meant to measure forearm muscle activation to provide objective recovery data that can supplement traditional rehabilitation. Current EMG systems are often expensive, cumbersome, and difficult to use. The goal of this study is to develop an affordable, accurate, and easy to use solution that improves access to EMG motor monitoring.

The key stakeholders include stroke survivors, clinicians, and the project sponsor, Dr. Espinoza-Wade. This report includes project introduction, background, objectives, and project …

Cerebral Palsy Detection In Neonatal Intensive Care Unit Infants, Anais Jeday, Shane Tryon, Bryanna Leary, Oleana Jacobson

Biomedical Engineering

The project is conducted in collaboration with Dr. Eric Espinoza-Wade to develop a secure, accurate wearable sensing system for infants in the Neonatal Intensive Care Unit (NICU) who have experienced asymmetric perinatal brain injury (APBI). Infants with APBI are at increased risk for developing unilateral cerebral palsy; however, clinical diagnosis is often delayed until 12–24 months of age, limiting opportunities for early intervention.

The goal of the project is to design a wearable system that securely attaches small, lightweight accelerometers to an infant’s limbs to quantify bilateral limb movement. Triaxial acceleration data will be used to detect movement asymmetries, which …

The Effects Of Adipose Tissue Trauma On Vascular Function After Collateral Arteriogenesis, Nathan Tran

Biomedical Engineering

Peripheral artery disease (PAD) affects an estimated 200 million people worldwide and is characterized by arterial narrowing that reduces perfusion to the limbs. Collateral arterioles can naturally restore blood flow through a remodeling process called arteriogenesis, making it a promising therapeutic target. However, the femoral artery ligation (FAL) model used to study arteriogenesis requires surgical access deep to the inguinal fat pad, and approaches for handling the fat pad vary widely across surgeons and protocols. Since adipose tissue harbors a large population of macrophages, the immune cells that govern arteriogenesis, fat pad manipulation may introduce confounding inflammatory stimuli that disrupt …

Lymph Node Dissection And Postoperative Complications After Lung Cancer Resection, Isheeta Madeka, Khaled Noueihed, Jacob Woodroof, Shale Mack, Hamza Rshaidat, Gregory L Whitehorn, Sneha Alaparthi, Scott H. Koeneman, Tyler R. Grenda, Nathaniel R. Evans, Iii, Olugbenga T. Okusanya

Department of Surgery Faculty Papers

Importance: Current lung cancer guidelines recommend lymph node sampling (LNS) with the 3 + 1 rule, which recommends station-based sampling with at least 3 N2 (mediastinal) and 1 N1 (hilar) nodal stations. Although there is oncologic benefit to rigorous LNS, potential negative impacts on surgical outcomes have not been well investigated. As adoption of the 3 + 1 rule increases given its formalization as guideline-concordant care, associations with adverse outcomes are crucial to characterize.

Objective: To evaluate whether satisfying the 3 + 1 rule is associated with increased postoperative complications.

Design, setting, and participants: This retrospective cohort study used the …

Feasibility And Acceptability Of A Mobile App And Wearable Device For Collecting Mental Health Survey And Passively Sensed Data Among Health Care Workers In Kenya: Mixed Methods Pilot Study, Linda Khakali, Andrew Aballa, Dorcas G. Mwigereri, Willie Njoroge, Rachel Maina, Amos Bunde, Peris Musitia, Moses Nyongesa, James Orwa, Jasmit Shah, Anthony Ngugi, Lukoye Atwoli, Amina Abubakar, Zul Merali

Brain and Mind Institute

Background: Mobile apps and wearable devices may help to facilitate early detection of mental health conditions by providing objective, real-time data to supplement other forms of feedback and diagnoses. Few studies have investigated the acceptability and feasibility of using a mobile app to track survey- and wearable-based data in mental health research in Sub-Saharan Africa.

Objective: This pilot study evaluated the feasibility and acceptability of using a mobile app and wearables to capture mental health–based survey data and passively sensed data among Kenyan health care workers.

Methods: A mixed methods study was conducted among health care workers …

Recurrent Upper Gastrointestinal Bleeding Due To Gastric Arteriovenous Malformation, Lavender Otom, Priyanka Panwar, Gerald Odong, Christopher Opio, Saleem Abdulkarim

Internal Medicine, East Africa

We present the case of a 45-year-old male with repeated episodes of upper gastrointestinal bleeding due to a gastric arteriovenous malformation (AVM). The case underscores the diagnostic challenges, multidisciplinary decision-making, and management considerations associated with gastrointestinal vascular malformations. Given the rarity of gastric AVMs and their potential for serious complications, this report highlights the importance of an integrated approach to diagnosis and treatment, including advanced imaging and endovascular interventions.

Increasing Efficiency And Flow In Primary Care Clinics Using Triage Protocols Based On The Donabedian Model, Verneita Mun

Doctor of Nursing Practice Projects

Purpose

This project evaluated the effectiveness of triage protocols based on the Donabedian model in increasing efficiency and flow in primary care clinics. Patients experienced extended wait times in primary care clinics, resulting in aggravated outcomes and dissatisfaction with care delivery. Healthcare providers also experienced stress and burnout due to workload and operational inadequacies. These inefficiencies mandated a quality improvement approach that addressed patient satisfaction, workflow optimization, and resource management.

Methods

This project used structured triage protocol based on the Donabedian model, which addressed the dimensions of structure, process, and outcomes. The proposed solution was disseminated through a quality improvement …

Bacterial Adaptation To Radiofrequency Electromagnetic Fields Based On Experiences From Ionizing Radiation, Ilham Said-Salman, Seyed Mohammad Javad Mortazavi, Sami El Khatib, Seyed Alireza Mortazavi, Lembit Sihver

Informatics and Engineering Systems Faculty Publications

Bacteria, part of the three domains of life (Eukarya, Archaea, and Bacteria), are constantly exposed to man-made electromagnetic fields, which often exceed the intensity of natural electromagnetic sources. In response to this exposure, bacteria have developed various defensive and resistant traits. This article presents an overview of both historical and recent research on how bacteria adapt to common sources of Radiofrequency Electromagnetic Fields (RF-EMF). The widespread use of mobile phones and Wi-Fi, both utilizing Radiofrequency (RF) radiation, raises potential public health concerns, which have been addressed by international organizations like the World Health Organization (WHO). Understanding how bacteria adapt to …

Partial Insect-Based Meal Inclusion In The Diets Of Ross® 308 Broilers Upregulates Growth And Immune Related Genes, Victor K. Rotich, Isaac M. Osuga, Mathew G. Gicheha, Shaphan Y. Chia, Jandouwe Villinger, Anderson N. Maina, Jinhua Xiao, Dennis Beesigamukama, Chrysantus M. Tanga

All Peer-Reviewed Publications

This work investigated the effects of black soldier fly ( Hermetia illucens L.) larvae meal (BSFLM) on growth- and immune-related gene expression in Ross 308 broilers. Birds were fed diets containing soybean meal (SBM), fishmeal (FM), combinations with BSFLM, or BSFLM alone. Growth, organ weights, immune genes [interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrotic factor alpha (TNF-α), interferon-gamma (IFN-γ)] and growth-related genes [chicken growth hormone (cGH), insulin growth factor 1 (IGF-1)] expression were measured. Our results demonstrate that birds fed FM+BSFLM had significantly higher final liveweight, average daily weight gain (ADG), and low feed conversion ratio. Birds fed FM+BSFLM showed highest …

Comparing Allometric Models To Machine Learning Models For Aboveground Biomass Estimation In Agroforestry Systems In Kenya, Samuel Irungu Kigotho, Kennedy Senagi, John Olukuru, David Masereti Makori, Elfatih M. Abdel-Rahman, Evans Omondi

All Peer-Reviewed Publications

This study compared traditional allometric models with machine learning (ML) techniques for accurately estimating aboveground biomass (AGB) in six Acacia species within Kenyan agroforestry systems. Using tree diameter at breast height (DBH) and total height as inputs, the research evaluated allometric models (Chave’s, Brown’s, and Henry’s) against ML models, including Gradient Boosting (GB), Extreme Gradient Boosting (XGBoost), Random Forest (RF), and Support Vector Regression (SVR). This research advances the field by benchmarking machine learning and classical allometric models at the species level within Kenyan agroforestry systems and employing SHapley Additive exPlanations (SHAP) for interpretability analysis. Model performance was validated using …

The Wake Of Addiction: Pharmacological Strategies For Sleep Disturbances In Stimulant Use Disorders, A Systematic Review, Isabella G Bourtin, Douglas J Calvillo, Jessica C Badawi, Joy M Schmitz, Scott D Lane, Jin Ho Yoon, Heather E Webber

Faculty, Staff and Student Publications

Background: A systematic review was conducted following PRISMA guidelines to identify human studies investigating pharmacological interventions and reported sleep outcomes among individuals with CUD or MUD.

Methods: PubMed and APA PsycInfo were searched from inception to January 2025 and risk of bias was assessed. Articles were included if they included human participants with either cocaine or methamphetamine dependence, administered a pharmacological treatment, and reported night-time sleep as an outcome using at least one rigorous measurement tool. Articles were excluded if they included animals, did not include pharmacological intervention (e.g., supplements or behavioral treatments), or only assessed baseline sleep or if …

Assessment Of Knee Laxity After Retrograde Intramedullary Nailing For Periprosthetic Distal Femur Fractures: A Cadaveric Study., Joshua P Rainey, Lucas A Anderson, Ian M Duensing, Jeremy M Gililland, Patrick J Kellam

Faculty, Staff and Student Publications

Objectives: Periprosthetic distal femur fractures have grown in volume because the rate of primary total knee arthroplasty (TKA) has increased. These injuries are increasingly treated with intramedullary nailing (IMN), but knee instability after retrograde IMN has not been well studied. A cadaveric study was performed to investigate TKA balance after retrograde femoral IMN. The main hypothesis was that retrograde femoral IMN preparation would lead to increased flexion space laxity.

Methods: A medial parapatellar approach and measured resection TKA technique were performed in 8 cadaveric knees. A tensioner was used to measure the flexion and extension spaces in millimeters and the …

Reimagining Power And Practice: Grantee Reporting For Greater Impact, Steven Lafrance, Jamae Morris, Lauri Valerio

The Foundation Review

The evaluation of Robert Wood Johnson Foundation’s (RWJF) Written Reports Alternative Project (WRAP) pilot revealed that Oral and Alternative Reporting (OAR) options offer a practical, values-aligned pathway to equitable, trust-based reporting that reduces burden while improving usefulness with a pathway to scale.

WRAP participants reported strengthened relationships and two-way learning, especially when conversations complemented or replaced written materials.

Recommendations for others considering OAR include: offer and codify choice, center questions that matter, design technology to support multiple formats, compensate grantee time for evaluation or additional learning-related asks, and train staff for relational learning.

RWJF’s experience demonstrates how reporting can be …

Adaptive Learning Partnerships In Action: Insights And Reflections From The Macarthur Foundation’S Big Bet On Nigeria, Julian Williams, Michael Moses

The Foundation Review

This article explores the evolution of the authors’ strategic learning partnership during their work together with the MacArthur Foundation’s Big Bet On Nigeria. The authors share practical insights into how foundations can cultivate learning relationships grounded in trust, aligned with priorities of program staff and grantees, and calibrated to generate timely, actionable insights.

The authors highlight the key principles that enabled them to help the program and grantees identify and adapt to emerging challenges, lessons, and needs, both within the programming context and in the foundation. In doing so, they offer a roadmap for funders and evaluators seeking to embed …

Journey To Tenure And Promotion: Lived Experiences Of Black Women In Historically Black Colleges And Universities, Rosalind L. Williams Lewis

Electronic Theses and Dissertations

This study affirms what Black feminist thought, intersectionality, and critical race theory have long suggested: Black women in academia face complex, systemic barriers but continue to rise with remarkable strength, resilience, and grace. Even in historically Black colleges and universities (HBCUs), spaces assumed to be nurturing, these women encounter racialized and gendered adversity. Literature has shown that Black women are by far the most educated group, but face challenges ascending into leadership and tenured roles on HBCU campuses. However, Black women in higher education have made great strides despite these challenges. The researcher conducted this phenomenological qualitative study to understand …

Paying For Participation: Equitable Compensation Models For Community Co-Researchers, Jamie Zimmerman, Prabhneet Girn

The Foundation Review

Community-engaged research is increasingly central to philanthropic practice, yet funders rarely provide guidance for compensating community members who participate as co-researchers. This gap is especially pronounced for youth, who often face administrative, legal, and developmental constraints that complicate what “fair pay” looks like in practice.

This article presents findings from a mixed-methods comparative case study of three youth participatory action-research projects involving 44 youth ages 16–24 across varied organizational settings. Data were collected through youth surveys, focus groups, staff interviews, financial analysis, and document review.

Findings show that each model carries distinct trade-offs related to feasibility, transparency, and administrative capacity, …

Decentralizing Dementia Research To The Us–Mexico Border: The Rio Grande Valley Ad-Rcmar As A Model For Translational Equity, Gladys E. Maestre, John Blangero, Eron Manusov, Gabriel A. De Erausquin, Francisco Fernandez, Silvia Mejia-Arango, Vincent P. Diego, Juan C. Lopez-Alvarenga, Claudia Alaniz, Neyra García, Rosa V. Pirela, Andrew Tsin, Michael Mahaney

School of Medicine Publications

Translational equity means ensuring that diagnostics, treatments, care models, and prevention strategies are developed and implemented so they work for populations with the greatest burden and least access to care. In Alzheimer's disease and related dementias (ADRD), where most evidence derives from highly educated, non-Hispanic White participants at large academic centers, translational equity is critical to prevent misclassification, limited access, and widening disparities and to ensure that underrepresented communities shape how new knowledge moves into practice. Hispanic and other populations in the United States are disproportionately affected by ADRD yet remain underrepresented in research, with gaps especially pronounced in high-poverty …

Invasion Patterns And Niche Dynamics Of The Pollinivorous Florida Calligrapher, Toxomerus Floralis (Diptera: Syrphidae) In The Afrotropical Region, Burgert Muller, John Midgley, Georg Goergen, Ali Al Jahdhami, Michelson Azo'o Ela, Terence Bellingan, Simon Cavaillès, Robert Copeland, Marc De Meyer, Martin Hauser, Allen Holmes, Ximo Mengual, Gabriel Nève, Menno Reemer, Jeff Skevington, Gunilla Ståhls, Eugène Sinzinkayo, John Smit, Axel Ssymank, Genevieve Theron, Kurt Jordaens

All Peer-Reviewed Publications

The rapid spread of Toxomerus floralis (Fabricius, 1798) (Diptera: Syrphidae) within the Afrotropical region is described. We characterise and compare the climatic niches of T. floralis in its native (Southern North America, Central America and South America) and invaded (Afrotropical Region) range to assess the potential for further expansion across Africa and beyond, and included future global climate models and socioeconomic pathways as projections. Occurrence data for native and invaded ranges were obtained from field sampling by authors, major collections of Afrotropical Syrphidae, collections records and occurrence data from the Global Biodiversity Information Facility (GBIF), including iNaturalist data. Single and …

Climate-Driven Stochastic Modelling Of Crimean-Congo Haemorrhagic Fever Transmission In Uganda, P. G. Kpatchana, J. Aduda, K. M. Agboka

All Peer-Reviewed Publications

Crimean-Congo haemorrhagic fever (CCHF) is a climate-sensitive tick-borne zoonosis that remains a significant public health concern in Uganda, where temperature and vapour pressure deficit influence tick ecology and consequently disease transmission. This study aimed to develop and analyse a climate-driven stochastic model for CCHF transmission among ticks, livestock, and humans under environmental variability in Uganda. A compartmental transmission model was formulated and extended into a stochastic differential equation framework by incorporating multiplicative environmental noise. Climate-dependent tick recruitment, development, and mortality were parameterized using district-level temperature and vapour pressure deficit data to capture spatial heterogeneity in transmission risk. Theoretical analyses based …

Higher Sodium Intake Is Associated With Episodic Memory Decline In Cognitively Unimpaired Older Males: A 6-Year Longitudinal Study, Francisca Chuwa, Stephanie R. Rainey-Smith, Hilal Salim Said Al Shamsi, Hamid Sohrabi, Kevin Taddei, Colin L. Masters, Ralph N. Martins, Samantha L. Gardener

Research outputs 2022 to 2026

Recent evidence has suggested an association between high sodium intake and development of cognitive impairment. However, while animal studies demonstrate consistent relationships between sodium intake and cognitive impairment, this relationship remains less clear in humans. Our aim was to investigate the relationship between self-reported baseline sodium intake and cognitive decline over 72 months. Cognitively unimpaired participants (n = 1208) from the Australian Imaging, Biomarkers and Lifestyle study were included (70.87 years of age; 41 % male). Participants completed a food frequency questionnaire to quantify sodium intake and underwent comprehensive neuropsychological assessment at baseline and four additional timepoints, 18 months apart. …