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Articles 13021 - 13050 of 1791766
Full-Text Articles in Entire DC Network
Effects Of Irrigation And Nitrogen Management On Yield And Leaching Risk In Organic And Conventional Broccoli Fields, Shane Egerstrom
Effects Of Irrigation And Nitrogen Management On Yield And Leaching Risk In Organic And Conventional Broccoli Fields, Shane Egerstrom
Master's Theses
Under regulatory pressures to reduce groundwater contamination by nitrate from fertilizer, such as those posed by the Central Coast Regional Water Quality Control Board’s Agricultural Order 4.0, a need exists to better understand interactions between irrigation and nitrogen (N) management. To increase N use efficiency (NUE), growers are encouraged to account for additional sources of N in their management plans, such as irrigation water N and preplant soil N. The availability of these N sources for plant uptake and how it is affected by other management conditions is not yet well documented. We conducted 6 field trials, 3 organic and …
Assessing Nitrogen Leaching Risk In Organic Vegetable Production, Megan Widle
Assessing Nitrogen Leaching Risk In Organic Vegetable Production, Megan Widle
Master's Theses
Nitrogen (N) leaching is the primary driver of groundwater contamination in agricultural regions. On California’s Central Coast, Agricultural Order 4.0 regulates this risk by constraining field-level N balances (N applied minus N removed). However, the assumption that unrecovered N is lost via leaching may not hold in organic and regenerative systems that promote soil organic matter accumulation. This study evaluated whether measured N leaching aligns with estimates derived from partial N budgets in organic systems, and whether management practices (intercrops, cover crops, and reduced tillage) can mitigate leaching risk. Four field trials were conducted to investigate N dynamics in organic …
Development Of A Video-Based Tool To Measure Motor Asymmetry In Infants At Risk For Hemiparesis, Roha Ali
Development Of A Video-Based Tool To Measure Motor Asymmetry In Infants At Risk For Hemiparesis, Roha Ali
Master's Theses
Congenital hemiparesis is a unilateral motor impairment stemming from brain injury in utero or early postnatally. Hemiparesis can be difficult to detect in early infancy with current clinical tools. Yet, early identification of motor asymmetry could play a key role in the design of effective early intervention and rehabilitation strategies. This thesis presents the development and validation of a video-based tool designed to extract infant limb movement data using DeepLabCut’s (DLC) machine learning network. The pipeline was developed using videos of typically developing (TD) infants and infants with Asymmetric Perinatal Brain Injury (APBI), all at or under 3 months corrected …
A Security Framework For Pacemaker Lead Failure: Anomaly Detection System And Failsafe Policy Considerations, Ethan Wagner
A Security Framework For Pacemaker Lead Failure: Anomaly Detection System And Failsafe Policy Considerations, Ethan Wagner
Master's Theses
Embedded system security in implantable medical devices (IMDs) remains an underexplored challenge due to the unique constraints of these systems. Specifically, pacemakers are optimized for ultra-low power consumption to maximize device lifespan, are highly resource constrained, and demand reliable and correct operation to prevent severe health consequences. These systems rely on sensing electrodes, called leads, to detect cardiac activity and stimulate the patient’s heart when appropriate. Therefore, pacemaker lead integrity is a critical issue, as malfunction or compromise can result in device failure jeopardizing patient safety.
The security framework presented in this thesis integrates several works to proactively detect and …
Perception Is Reality: Evaluating Transportation Satisfaction And Utilization In Continuing Student Housing At Cal Poly, Lucas Owens
Master's Theses
As higher education institutions increasingly mandate on-campus living to foster student success, the built environment becomes a critical determinant of daily mobility. California Polytechnic State University (Cal Poly) is transitioning to a two-year residency requirement and tightening vehicle restrictions. This thesis evaluates how the spatial and built-environment realities of peripheral housing complexes in Cerro Vista Apartments and Poly Canyon Village shape student transportation satisfaction and utilization, and emergency evacuation preparedness.
Employing a mixed-methods approach, this research triangulates data from 79 student surveys and 10 semi-structured interviews. The findings indicate that supplementing traditional metrics of proximity with localized spatial data presents …
A2s Uplink Latency Minimization For Wildfire Monitoring Systems Using Mbse And Stochastic Modeling, Luis Giovanni Wang
A2s Uplink Latency Minimization For Wildfire Monitoring Systems Using Mbse And Stochastic Modeling, Luis Giovanni Wang
Master's Theses
Wildfire response depends on how quickly a detection reaches the people who act on it, and the slowest remaining step is often the link that carries an alert from a remote sensing platform to a satellite. This thesis models the latency of that link, the Air-to-Space uplink, for a wildfire-monitoring UAV that carries a Starlink terminal and sends an ALERT packet to a serving Low Earth Orbit satellite. The uplink is difficult to predict because both the UAV and the satellite move, and because the wildfire environment degrades the channel at the moment the data matters most.
The thesis uses …
Synthesis And Characterization Of A Graphene Oxide-Zif-8 Composite For Enhanced Post-Combustion Carbon Capture, Sydney Cooper
Synthesis And Characterization Of A Graphene Oxide-Zif-8 Composite For Enhanced Post-Combustion Carbon Capture, Sydney Cooper
Master's Theses
Carbon dioxide (CO₂) emissions from fossil fuel combustion are a major contributor to climate change and its associated environmental impacts. The current standard technology for post-combustion carbon capture, aqueous amine scrubbing, is effective but requires significant regeneration energy and has high operational costs. As a result, solid sorbents have been investigated as lower-energy alternatives. Metal-organic frameworks (MOFs) are a promising class of porous nanomaterials due to their high surface area, tunable pore structures, and adjustable surface chemistry. Among them, zeolitic imidazolate framework-8 (ZIF-8) has high thermal and chemical stability, hydrophobicity, and favorable adsorption properties. However, conventional synthesis methods often rely …
Multimodal Machine Learning For Soil Burn Severity Mapping Across California Wildfires, Sanjana Checker
Multimodal Machine Learning For Soil Burn Severity Mapping Across California Wildfires, Sanjana Checker
Master's Theses
Accurate mapping of soil burn severity (SBS) is critical for post-fire watershed management, erosion risk assessment, and ecological recovery planning, yet traditional field-based approaches remain costly, time-intensive, and spatially limited. This thesis presents a machine learning pipeline for wall-to-wall SBS classification across California wildfires using multi-sensor satellite imagery, terrain derivatives, and bioclimatic covariates. Field-collected SBS observations (n = 2,180) from 52 wildfires occur- ring between 2013 and 2025, sourced from the U.S. Forest Service and CAL FIRE, were used to train and evaluate multiple classification architectures within a Google Earth Engine and Google Cloud-based prediction framework. After upsampling the unburned …
Limiting Inconsistencies In Legal Languages, Sarah B. Lawsky - Professor Of Law
Limiting Inconsistencies In Legal Languages, Sarah B. Lawsky - Professor Of Law
Vanderbilt Journal of Entertainment & Technology Law
Inconsistencies play different roles in law and in logic, respectively, and programming languages designed to code law should therefore, when possible, be designed to prevent the encoding of inconsistencies. While inconsistencies in standard logic “explode” the argument, allowing anything at all to be proven, apparent inconsistencies in law simply indicate that further guidance is needed. Programming languages should be limited not because such inconsistencies do not exist in the statute, but rather exactly because they do. Inconsistencies in the law should, as they are now, be addressed by Congress, the courts, and administrative agencies, and any computer code implementing the …
Open Secrets, Robin Feldman Distinguished Professor Of Law, Vaughn Goehrig -- Center For Innovation
Open Secrets, Robin Feldman Distinguished Professor Of Law, Vaughn Goehrig -- Center For Innovation
Vanderbilt Journal of Entertainment & Technology Law
Patents and trade secrets were never intended to meet, but in the world of biologic drugs, they’ve become as thick as thieves. Patent law’s disclosure requirement has demanded far too little of biologics manufacturers—allowing them to keep vital manufacturing details under trade secret lock and key. This intellectual property patchwork has been devastating for drug affordability: Because the most critical manufacturing information remains hidden, makers of follow-on biologics (called biosimilars) are often stuck reinventing the wheel, even after the original patents have expired. This Article makes two principal contributions to illuminating this problem. First, it presents, for the first time …
Patent Law's Trade Remedy, Michael L. Doane
Patent Law's Trade Remedy, Michael L. Doane
Vanderbilt Journal of Entertainment & Technology Law
Although a trade remedy, not an intellectual property rights statute, Section 337 of the Tariff Act of 1930 plays an important and controversial role in the enforcement of intellectual property rights in the United States. As a trade remedy, Section 337 is designed and intended to promote innovation and investment in the United States through support of statutorily defined domestic industries against unfair competition from infringing imported products. This Article analyzes Section 337 as a trade remedy from the perspective of intellectual property rights owners and innovators such as start-up companies, universities, individual inventors, and other research and development-focused entities. …
Editorial: Food Safety In The Context Of One Health: Current Trends, Challenges And Perspectives, Daniel Ekhlas, Yosra A Helmy, Federica Savini, Arturo Soro, Elena Alexa
Editorial: Food Safety In The Context Of One Health: Current Trends, Challenges And Perspectives, Daniel Ekhlas, Yosra A Helmy, Federica Savini, Arturo Soro, Elena Alexa
Research Outputs: 2025-Present
No abstract provided.
Accessibility In The Edtech Era: The Growth In Implementation Oflearning Technologies And Thestudents Who Are Left Behind, Madeleine Braksick
Accessibility In The Edtech Era: The Growth In Implementation Oflearning Technologies And Thestudents Who Are Left Behind, Madeleine Braksick
Vanderbilt Journal of Entertainment & Technology Law
Educational Technology (EdTech) has gained popularity in recent years, enabling distance learning and connectedness across school districts, and among students, teachers, and families alike. However, vague or nonexistent standards for regulating these technologies have led to students with rights to special education services not having those services upheld to the same standard as traditional educational mechanisms. While the Individuals with Disabilities Education Act (IDEA) has been modified over time to form heightened standards for making education appropriate for all students, it has consistently fallen short in its regulation of both assistive and educational technologies. This Note explores the consequences of …
Collaboration In Context: The Present And Future Of Coordinated Care For New Mexico's Military-Connected Population, Zachary Bridgewater, Vincent Delsignore, Mary Rachel Keville, Lisa Marie Murray
Collaboration In Context: The Present And Future Of Coordinated Care For New Mexico's Military-Connected Population, Zachary Bridgewater, Vincent Delsignore, Mary Rachel Keville, Lisa Marie Murray
Institute for Veterans and Military Families
With the support of the New Mexico State Legislature, the D’Aniello Institute for Veterans and Military Families (IVMF) led a multi-phase project to design a coordinated care system for New Mexican service members, veterans, and their families. In the project’s first phase, the IVMF conducted a landscape assessment to understand the needs of the military-connected community and examined the viability of a coordinated care system for the state. Key findings included strong support for coordinated care amongst veteran serving organizations, a fragmented service landscape across the state, structural barriers to care caused by rurality and geographic concentrations of resources, and …
Dentistry And The Law: The Need To Designate A Patient Of Record, Daniel Schulte Jd
Dentistry And The Law: The Need To Designate A Patient Of Record, Daniel Schulte Jd
The Journal of the Michigan Dental Association
This legal column addresses the legality of delegating dental procedures to hygienists before a dentist has examined the patient. Author Dan Schulte clarifies that under Michigan’s Administrative Code, procedures may only be delegated if the individual is a "patient of record". This status requires a dentist to have personally performed an evaluation and diagnosis within the previous 24 months. Consequently, seeing new patients for cleanings or X-rays before a dentist's involvement is non-compliant with state law.
J Mich Dent Assoc June 2026
The Journal of the Michigan Dental Association
Each month, the Journal of the Michigan Dental Association delivers news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200-plus members. It remains the main publication reaching Michigan dentists and is available worldwide through ADA Commons.
The June 2026 (Volume 108, No. 6) issue of the Journal is published in digital format to provide updates and insights for Michigan's oral health community and MDA members. Print editions occur every other month beginning with January.
The June 2026 issue of the Journal of the Michigan Dental Association provides association updates, legal advice, and clinical …
Better Questions Make Better Dentists: Why Values-Based Conversations Lead To Better Outcomes, Anish Gupta Dds
Better Questions Make Better Dentists: Why Values-Based Conversations Lead To Better Outcomes, Anish Gupta Dds
The Journal of the Michigan Dental Association
Dr. Anish Gupta argues that technical proficiency in dentistry must be guided by values-based communication to ensure optimal patient outcomes. He critiques traditional informed consent that merely lists procedural options, suggesting it can lead to confusion if a patient's primary motivations—such as dignity or quality of life—are not addressed. By slowing down to uncover what truly matters to the patient, dentists can provide better guidance and clinical judgment. Gupta emphasizes that alignment with patient values removes obstacles to treatment acceptance.
From The Editor: The Journal: Supporting Michigan’S Dental Community, Romesh Nalliah
From The Editor: The Journal: Supporting Michigan’S Dental Community, Romesh Nalliah
The Journal of the Michigan Dental Association
Editor-in-Chief Dr. Romesh Nalliah explores the concept of "community" as a shared responsibility within the dental profession. He positions the Journal of the Michigan Dental Association as a vital tool for connecting practitioners and delivering rigorously reviewed scientific content to guide clinical decision-making. While acknowledging technological advances like artificial intelligence, Nalliah maintains that "soft skills"—including listening, empathy, and critical thinking—remain the most essential factors for success. He encourages members to utilize the Journal for mentorship and professional support.
Beyond Regulation: Why Europe Must Lead Ai Stewardship In Health, Luca Saba, Ignazio R. Marino
Beyond Regulation: Why Europe Must Lead Ai Stewardship In Health, Luca Saba, Ignazio R. Marino
Department of Surgery Faculty Papers
No abstract available
Impact Of Race And Acculturation On Lung Cancer Screening Eligibility: A Multicenter Lung Cancer Cohort Study, Eunji Choi, Christine S. Shusted, Harrison Yang, Haley M. Evans, Julia G. Katcher, Yiwey Shieh, Anil Vachani, Katharine Rendle, Julie A. Barta
Impact Of Race And Acculturation On Lung Cancer Screening Eligibility: A Multicenter Lung Cancer Cohort Study, Eunji Choi, Christine S. Shusted, Harrison Yang, Haley M. Evans, Julia G. Katcher, Yiwey Shieh, Anil Vachani, Katharine Rendle, Julie A. Barta
Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers
No abstract provided.
A Simulation To Compare Models For A Longitudinal Ordinal Response With A Multilevel Cross-Classified Data Structure, Rachel S. Perlin
A Simulation To Compare Models For A Longitudinal Ordinal Response With A Multilevel Cross-Classified Data Structure, Rachel S. Perlin
Dissertations, Theses, and Capstone Projects
This is a simulation study that compares four models for analyzing three-level longitudinal cross-classified data with an ordinal outcome, treatment effect and a category-specific effect. The models include the cumulative model, the sequential model, the adjacent category model, and a metric model. Data were generated for each of the first three models with 27,000 generated datasets each, totaling 81,000. The datasets vary along three continuous variables: the number of level-3 units, the ratio of treatment groups to control groups, and the treatment effect size. The outcome has four ordinal response categories. Each model had two predictor variables: treatment and time. …
Essays On The Economics Of Aging: Structural And Machine Learning Approaches, Alexander S. Kwon
Essays On The Economics Of Aging: Structural And Machine Learning Approaches, Alexander S. Kwon
Dissertations, Theses, and Capstone Projects
Population aging has made the study of older workers’ economic behavior increasingly important for understanding labor markets, retirement systems, and public policy. In many advanced economies, rising old-age dependency ratios have increased the need to understand labor-supply, retirement, and savings decisions later in life (OECD, 2025). In the United States, these issues are especially important because Social Security faces long-run financing pressure, with the Old-Age and Survivors Insurance Trust Fund projected to be depleted around 2033 (U.S. Social Security Administration, Office of the Chief Actuary, 2025). Longer life expectancy increases the expected length of retirement and raises the fiscal importance …
Technology Before, During, And After Incarceration: Current Product Landscape, Sociotechnical Concerns, And Legal Considerations In The U.S. Context, Yael Eiger, Taylor Hansen, Teanna Barrett, Jevan Hutson, Bryce Clayton Newell, Franziska Roesner
Technology Before, During, And After Incarceration: Current Product Landscape, Sociotechnical Concerns, And Legal Considerations In The U.S. Context, Yael Eiger, Taylor Hansen, Teanna Barrett, Jevan Hutson, Bryce Clayton Newell, Franziska Roesner
Articles
Emerging technology, including AI, is proliferating throughout the U.S. carceral system. These technologies are marketed to prisons and police departments and then procured using taxpayer money. Previous investigative reporting has exposed troubling kickback schemes, unconstitutional data collection practices, and biased algorithmic outcomes in a handful of prominent technologies (e.g., Flock, Palantir, Clearview AI, COMPAS). In this work, we consider the broader ecosystem of carceral technologies: we catalog 122 products from 53 companies selling technology to carceral institutions. In a collaboration among computer science, law, and surveillance studies scholars, we surface sociotechnical, ethical, and legal concerns related to the use and …
Thermally Induced Color Changes In Iron Oxide Pigments Used In Architectural Coatings, Han Diep
Thermally Induced Color Changes In Iron Oxide Pigments Used In Architectural Coatings, Han Diep
Master's Theses
The 2025 Palisades Fire was one of the most destructive wildfires in the history of Los Angeles, destroying thousands of structures and severely impacting the communities after. This widespread destruction demonstrated an urgent need for more effective wildfire prevention strategies. Architectural coatings do not only provide aesthetics and protection against environmental conditions but can also function as a thermal indicator when a fire breaks out. This study examines the thermally induced color transformation of iron oxide pigments, commonly used in earthtone paint, to provide information relevant to CAL FIRE for improved analysis of wildland-urban interface (WUI) fire behavior and mitigation …
Assessing Aflatoxin Knowledge, Perceptions, And Related Practices, In A Rural Coastal Community: A Population-Based Cross-Sectional Survey, Rosebella Iseme, Joseph Abuodha, Anthony Ngugi, Innocent Abayo, Mansoor Saleh
Assessing Aflatoxin Knowledge, Perceptions, And Related Practices, In A Rural Coastal Community: A Population-Based Cross-Sectional Survey, Rosebella Iseme, Joseph Abuodha, Anthony Ngugi, Innocent Abayo, Mansoor Saleh
Population Health, East Africa
Background
Aflatoxin contamination is a significant yet under-addressed food safety challenge in low-resource settings, driven by a complex interplay of environmental, agricultural, and socio-economic factors. Limited access to agricultural inputs, inadequate post-harvest handling and storage, and weak regulatory enforcement alongside food scarcity and climate change heighten the risk of contamination and exposure. Human exposure is associated with serious health consequences, including hepatocellular carcinoma, immune suppression, and childhood stunting. Although aflatoxin is increasingly recognized as a global food safety concern, little is known about community-level knowledge, risk perceptions, and preventive practices. This study examined household heads’ awareness, perceptions, and behaviours related …
Satellite-Derived Longitudinal Evidence Of Flood Effects On Community Water And Sanitation Resilience In Coastal Kenya, Felix Oluoch, Rosebella Iseme, Fredrick Gudda, Alfred Keter, Rachel Odhiambo, Jai Das, Zulfiqar Bhutta, Anthony Ngugi
Satellite-Derived Longitudinal Evidence Of Flood Effects On Community Water And Sanitation Resilience In Coastal Kenya, Felix Oluoch, Rosebella Iseme, Fredrick Gudda, Alfred Keter, Rachel Odhiambo, Jai Das, Zulfiqar Bhutta, Anthony Ngugi
Population Health, East Africa
Background Flooding can disrupt water, sanitation and hygiene services in low-income rural and peri-urban settings, yet there is limited quantitative evidence on how repeated flood exposure affects safe water and sanitation over time at the level of Community Health Units (CHUs), which are the operational units for primary health care in Kenya.
Methods We analysed repeated CHU-level data from ten Community Health Units in Kilifi County, Kenya, across eleven surveillance rounds from 2017 to 2024. For each round, we calculated the percentage of households with safe drinking water and with access to a functional latrine, and linked these outcomes to …
Exploring Csf Microrna Signatures As Diagnostic Biomarkers In Adult-Type Diffuse Gliomas, Maryam Pirhoushiaran, Kamilah Walker-Charles, Tsung-Hung Yao, Satwikreddy Putluri, Nehal Patel, Daniel H Wang, Isabel Wang, Srividya Arjuna, Antonio Dono, Angel Bueno, Sophia Nguyen, Ashish P Balar, Jason T Huse, Suprateek Kundu, Yoshua Esquenazi, Chirag B Patel, Sujit S Prabhu, Frederick F Lang, Leomar Y Ballester
Exploring Csf Microrna Signatures As Diagnostic Biomarkers In Adult-Type Diffuse Gliomas, Maryam Pirhoushiaran, Kamilah Walker-Charles, Tsung-Hung Yao, Satwikreddy Putluri, Nehal Patel, Daniel H Wang, Isabel Wang, Srividya Arjuna, Antonio Dono, Angel Bueno, Sophia Nguyen, Ashish P Balar, Jason T Huse, Suprateek Kundu, Yoshua Esquenazi, Chirag B Patel, Sujit S Prabhu, Frederick F Lang, Leomar Y Ballester
Faculty, Staff and Student Publications
Mutations in isocitrate dehydrogenase (IDH) genes, specifically IDH1 and IDH2, are frequently observed in diffuse gliomas (DG) and define distinct molecular subtypes, namely IDH-wildtype and IDH-mutant. Abnormal expression of extracellular vesicle-derived microRNAs (EV-miRNAs) in the cerebrospinal fluid (CSF) of DG patients may serve as minimally invasive diagnostic and prognostic biomarkers. To investigate this potential, we employed miRNA-sequencing (miRNA-seq), quantitative real-time PCR (qRT-PCR), and multivariable logistic regression (MLR) to identify differentially expressed microRNAs (DE-miRNAs) in CSF samples from DG patients. qRT-PCR analysis demonstrated that EV-miR-21-5p effectively differentiated CSF from glioblastoma (GBM) patients versus controls (p = 0.012, AUC = 0.84) and …
Nlrp3 Inflammasome: A Link Between Systemic Infection And Alzheimer’S Disease, Tatiana Barichello, Felipe Dal-Pizzol
Nlrp3 Inflammasome: A Link Between Systemic Infection And Alzheimer’S Disease, Tatiana Barichello, Felipe Dal-Pizzol
Faculty, Staff and Student Publications
No abstract provided.
Exploring Csf Microrna Signatures As Diagnostic Biomarkers In Adult-Type Diffuse Gliomas, Maryam Pirhoushiaran, Kamilah Walker-Charles, Tsung-Hung Yao, Satwikreddy Putluri, Nehal Patel, Daniel H Wang, Isabel Wang, Srividya Arjuna, Antonio Dono, Angel Bueno, Sophia Nguyen, Ashish P Balar, Jason T Huse, Suprateek Kundu, Yoshua Esquenazi, Chirag B Patel, Sujit S Prabhu, Frederick F Lang, Leomar Y Ballester
Exploring Csf Microrna Signatures As Diagnostic Biomarkers In Adult-Type Diffuse Gliomas, Maryam Pirhoushiaran, Kamilah Walker-Charles, Tsung-Hung Yao, Satwikreddy Putluri, Nehal Patel, Daniel H Wang, Isabel Wang, Srividya Arjuna, Antonio Dono, Angel Bueno, Sophia Nguyen, Ashish P Balar, Jason T Huse, Suprateek Kundu, Yoshua Esquenazi, Chirag B Patel, Sujit S Prabhu, Frederick F Lang, Leomar Y Ballester
Faculty, Staff and Student Publications
Mutations in isocitrate dehydrogenase (IDH) genes, specifically IDH1 and IDH2, are frequently observed in diffuse gliomas (DG) and define distinct molecular subtypes, namely IDH-wildtype and IDH-mutant. Abnormal expression of extracellular vesicle-derived microRNAs (EV-miRNAs) in the cerebrospinal fluid (CSF) of DG patients may serve as minimally invasive diagnostic and prognostic biomarkers. To investigate this potential, we employed miRNA-sequencing (miRNA-seq), quantitative real-time PCR (qRT-PCR), and multivariable logistic regression (MLR) to identify differentially expressed microRNAs (DE-miRNAs) in CSF samples from DG patients. qRT-PCR analysis demonstrated that EV-miR-21-5p effectively differentiated CSF from glioblastoma (GBM) patients versus controls (p = 0.012, AUC = 0.84) and …
Scaling The Production Of Bromine-76 And Bromine-77 Labeled Poly-Adp-Ribose-Polymerase-Targeted Theranostics For Preclinical Use., Taylor R Johnson, Hong Beom Lee, Yngve Guttormsen, Jason C Mixdorf, Todd E Barnhart, Jonathan W Engle, Paul A Ellison
Scaling The Production Of Bromine-76 And Bromine-77 Labeled Poly-Adp-Ribose-Polymerase-Targeted Theranostics For Preclinical Use., Taylor R Johnson, Hong Beom Lee, Yngve Guttormsen, Jason C Mixdorf, Todd E Barnhart, Jonathan W Engle, Paul A Ellison
Faculty, Staff and Student Publications
Background: Bromine-76, a positron emitting radionuclide for positron emission tomography (PET) imaging, and bromine-77, an Auger electron (Ae) emitting radionuclide, make a unique halogen theranostic pair. These isotopes have previously been used to synthesize a rucaparib-derived, poly-ADP-ribose polymerase inhibitor ([76/77Br]RD1). As [77Br]bromide activity in [76/77Br]RD1 radiosyntheses increased, coincident with solid target hardware changes in our facility, radiopharmaceutical yield became less reproducible. This work describes the modifications to this hardware, distillation procedures, and [76/77Br]bromide solution chemistry to enable reproducible production of preclinical quantities of [76/77Br]RD1.
Results: Isotopically enriched cobalt selenide targets had production yields of 50.7 ± 8.7 MBq/µAh for bromine-76 …