Digital Commons Network^™

Factors Associated With Contraceptive Discontinuation Among Women In The U.S., Moradi Aljadani

Electronic Theses and Dissertations 2020 - Present

Background: Contraceptive discontinuation is a significant public health concern in the United States, contributing to unintended pregnancies and associated health, social, and economic consequences. Despite the availability of a wide range of contraceptive methods, many women discontinue use prematurely due to a variety of personal, social, cultural, and systemic factors. However, limited research has comprehensively examined these factors at the national level, particularly within a theoretical framework that captures the multidimensional influences on contraceptive decision-making. Objective: This study aimed to assess the factors associated with contraceptive method discontinuation among women in the U.S, guided by Ray’s Theory f …

A Self-Sustaining Autonomous System For Long-Term Arctic Monitoring, Wenqiang Xu

Electronic Theses and Dissertations 2020 - Present

The accelerated melting of Arctic sea ice poses critical challenges to global climate stability, marine ecosystems, and navigation safety. To address the need for continuous, high-resolution monitoring of the Arctic environment, this dissertation explores the development and feasibility of a Self-sustaining Autonomous System (SAS) for long-term Arctic observation. The proposed system is designed to overcome the limitations of traditional fixed or drifting buoys, as well as the range and endurance constraints of drones and Autonomous Underwater Vehicle (AUV)s, by utilizing a Small Waterplane Area Twin Hull (SWATH) Unmanned Surface Vehicle (USV) as a core observation platform. The wind-powered SWATH harnesses …

Psychometric Properties Of A New Acculturation Scale For Latinos/Hispanics, Alicia Goytizolo

Electronic Theses and Dissertations 2020 - Present

The current study evaluated the psychometric properties of the newly developed Multi-Ethnic Acculturation Scale (MAS), a multidimensional instrument designed to assess behavioral and cognitive aspects of cultural adaptation among Hispanic/Latino individuals in the United States. A sample of 208 adults from diverse Hispanic backgrounds completed the MAS alongside two validated acculturation measures: the Short Acculturation Scale for Hispanics and the Vancouver Index of Acculturation. Exploratory factor analyses revealed a partially distinct but moderately correlated factor structure for both American and Latino cultural orientation subscales, supporting a bidimensional conceptualization of acculturation. Internal consistency was high across both subscales (Cronbach’s α > .90), …

Exploring Emotional Awareness Through Interactive Design, Mona Gandomkar

Electronic Theses and Dissertations 2020 - Present

This research was inspired by my emotional journey after relocating to the United States. Navigating a new culture, language barriers, and unfamiliar routines brought a complex mix of emotions. These experiences led me to begin to better understand and manage my emotional responses. That process revealed the importance of emotional awareness and became the foundation for my exploration into how design can help individuals recognize and engage with their emotions more meaningfully.

Emotions are significant in human life, from social relationships to decision-making. However, many people fail to understand their emotions or how to control them. Individuals experience emotions differently, …

Quackery Unmask’D: Defining Quackery In English And American Vernacular Medical Works, C. 1600-1800, Katherine Rose Horan

Electronic Theses and Dissertations 2020 - Present

This thesis argues that, from 1600 to 1800, healers in both England and America conceptualized quackery through an evolving understanding of what made a medical practitioner “acceptable.” Through a close examination of vernacular medical print published in both England and America throughout the seventeenth and eighteenth centuries, this thesis complicates earlier understandings of quackery as being disconnected from politics and social biases. Instead, medical authors used social position—specifically gender, race, and religion—and medical philosophy as ways to identify quacks. In England, the Royal College of Physicians used quackery to delegitimize their opponents, while critics of the College did the same. …

Educational Case: Disseminated Intravascular Coagulation In A Patient With Cancer, Kripa Ahuja, Richard M. Conran

Department of Biomedical and Translational Sciences Faculty Publications

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see https://www.sciencedirect.com/journal/academic-pathology/about/pathology-competencies-for-medical-education-pcme.

Cannabinoid-2 Receptor Activation Attenuates Sulfur Mustard Analog 2-Chloroethyl-Ethyl-Sulfide-Induced Acute Lung Injury In Mice, Gregory Nicholson, Nicholas Richards, Janette Lockett, My Boi Ly, Raj V. Nair, Woong-Ki Kim, K. Yaragudri Vinod, Nagaraja Nagre

Department of Biomedical and Translational Sciences Faculty Publications

Background: Exposure to sulfur mustard (SM; 2,2′-dichlorodiethyl sulfide) causes toxicity in the human body, particularly the lungs. The molecular mechanisms of SM-induced lung damage are elusive, and no effective treatments exist. This study explores the anti-inflammatory potential of cannabinoid receptor 2 (CB2R) activation in mitigating acute lung injury (ALI) and inflammation induced by 2-chloroethyl ethyl sulfide (CEES), a structural analog of SM. Methods: C57BL/6J mice were exposed to CEES via intratracheal administration to model ALI. CB2R activation was achieved through the intraperitoneal administration of HU308, a selective synthetic agonist. ALI and inflammation were evaluated at 48 h post-exposure to CEES. …

The Central Role For Troponin C Amino-Terminal ⍺-Helix In Vertebrate Thin Filiment Ca²⁺-Activation, Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase

Department of Biomedical and Translational Sciences Faculty Publications

Troponin C (TnC) is the Ca²⁺-sensing subunit of troponin that is responsible for activating thin filaments in striated muscle, and, in turn, for regulating the systolic and diastolic contractile function of cardiac muscle. The secondary structure of vertebrate TnC is mainly composed of α-helices, with nine helices named sequentially, starting from the amino terminus, from N to A–H. The N-helix is a 12-residue-long α-helix located at the extreme amino terminus of the protein and is the only helical structure that does not participate in forming Ca²⁺-binding EF-hands. Evolutionarily, the N-helix is found only in TnC from mammalian species and most …

Cellular And Molecular Mechanisms Of Lung Regeneration, Repair, And Fibrosis, Volume Ii, Yong Qiu, Xiao Xiao Tang, Shigeyuki Shichino, Prem Prakash Kushwaha, Yan Y. Sanders, Remo Castro Russo, Chunheng Mo

Department of Biomedical and Translational Sciences Faculty Publications

[Introduction] Organ fibrosis represents a substantial a major contributor to global disease burden, implicated in over 30% of cases leading to disability-associated and fatal conditions. Among these conditions, idiopathic pulmonary fibrosis (IPF) stands as a progressive and frequently fatal interstitial lung disease characterized by aberrant extracellular matrix deposition and parenchymal scarring. The prognosis for IPF patients is poor, with a median survival time of just 3–5 years (Bhattacharya and Ramachandran, 2023; Lederer and Martinez, 2018, Ma et al., 2024, Wei et al., 2024). Current FDA-approved therapeutics, Pirfenidone and Nintedanib, demonstrate capacity to attenuate functional decline in pulmonary fibrosis but remain …

Phenotype Specific Nuclear Lamina Remodeling In Hipsc Derived Cardiomyocytes Bearing Tnnt2 Sarcomeric Variants, Isabella Leite Coscarella, Olalekan H. Usman, Lili Wang, Maicon Landim-Vieira, Lillian Wirstiuk, Amber N. Brown, Diego A. R. Zorio, Brian K. Washburn, Cynthia Vied, Bjorn C. Knollmann, Christopher Solís, Vitold E. Galkin, P. Bryant Chase, J. Travis Hinson, Jerome Irianto, Jose Renato Pinto

Department of Biomedical and Translational Sciences Faculty Publications

[Summary] Cardiomyocytes endure physical stress from the myocardium environment while generating their own mechanical strains. The force generated by sarcomeres is transmitted both longitudinally to adjacent sarcomeres and laterally to the cytoskeleton via intermediate filaments. This mechanical stimulus impacts other organelles, including the nucleus, thus playing a vital role in sensing and signaling nuclear adaptations. However, there is limited understanding of how changes in cardiac contractility affect nuclear mechanics. Here, we sought to investigate the effects of hyper- and hypo-contractility in nuclei of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) bearing TNNT2 pathogenic variants associated with hypertrophic (HCM) or dilated …

Saferespirator: Comprehensive Database For N95 Filtering Facepiece Respirator Leak Detection Including Infrared, Rgb Videos, And Quantitative Fit Testing, Geoffrey Marchais, Mohamed Arbane, Barthelemy Topilko, Jean Brousseau, Clothilde Brochot, Yacine Yaddaden, Ali Bahloul, Xavier Maldague

Études primaires

The COVID-19 pandemic underscored the challenges of performing mandatory Quantitative Fit Tests (QNFT) for healthcare professionals and the limitations of self-administered fit checks. To address this, it is crucial to develop faster and more efficient methods for detecting, locating, and quantifying leaks in Filtering Facepiece Respirators (FFRs), providing wearers with immediate feedback on their safety. Infrared (IR) technology, which relies on temperature variation analysis around the face seal, has proven effective for locating leaks but has not yet achieved automated quantification. This paper introduces a validated protocol for creating a comprehensive database to advance automatic leak detection. The database includes …

The Vital Role Of Interpreters In The Deaf Community: Navigating Accessibility Amidst Declining Deia Initiatives, Andrew Kovacs

Williams Honors College, Honors Research Projects

The catalyst for this research project stems from the rollback of Diversity, Equity, Inclusion, and Accessibility (DEIA) initiatives under the current presidential administration. Executive Orders from the presidential office have caused budget cuts and pauses in federal programs that affect all types of communities across the United States. For the Deaf community, funding for federal and state programs aimed at training ASL interpreters, helping Deaf individuals find jobs, and other communicative tools used by native signers has been paused. Despite the urgency of this issue, few studies have looked at the intersection of Deaf accessibility and the decline of DEIA …

Ct: Paws, Pools & Preparedness- A Community Event Promoting Water Safety Through Strategic Communication, Madison Nolan

Williams Honors College, Honors Research Projects

Paws, Pools & Preparedness is an educational community event tailored as a School of Communications Honors project. It will take place at the Wadsworth YMCA's Grizzly Pool in early August and feature a live demonstration by a search and rescue dog and handler to teach children and families about water safety and emergency preparedness in an entertaining, interactive way. The activity entails a rescue demonstration, safety briefing, and meet-and-greet session with the dog. The student organizer handles all planning, promotion (by hard-copy flyers), and staging. Involving all phases of the project is Smith's (2004) strategic PR model and theories of …

Social Media Through A Binary Lens: The Impact On College Students & Their Mental Health, Piper Mallchok

Williams Honors College, Honors Research Projects

It is important to first understand how individuals use social media so that we can then understand how and why their use will change the individual impact social media will have. Some students experience a decline in their mental health when their social media use changes. There is an abundance of research on college students and social media, respectively, that also addresses gender as a variable. In this review, the research will be studied to further understand the voices of those who are not commonly included in research that operates under a gendered framework. Additionally, these ideas will be compared …

Selling Trust: The Evolution Of Relationship Selling In The Investment Industry, Kaden N. Kroslak, Frederik Beuk

Williams Honors College, Honors Research Projects

This honors research project examines how relationship selling in the investment industry, especially within registered investment advisory firms, has evolved over time. Advisor-client relationships are being shaped by technology, analytics, regulations, and a frenzy of information. This literature review explores whether the stated factors of technology, credibility, regulations, information access, and fiduciary duty, caused change in how investment advisors create, maintain, and grow client relationships within the context of trust. The project styling, in form of a literature review analyzes peer-reviewed studies on financial technology, artificial intelligence, psychological approaches, and regulatory systems. The outcome is a paper which helps fill …

Something Different Like Us: A Children's Book Project, Isabella B. Gonzalez

Williams Honors College, Honors Research Projects

The purpose of this project is to write and begin illustrating a children’s book. The end goal is to complete the full script, finish rough sketches of the entire book, fully illustrate the cover and first two pages, and present the project in the form of an exhibition.

This story follows three little chicks (Dixie, Charlotte, and Phoebe) around a small farmyard as they encounter a new type of animal, a family of rabbits. For the majority of the book, the chicks fear the newcomers since they look so different. The sisters judge, avoid, and suppose the worst of the …

Daf-12’S Effects On Lifespan In C. Elegans, Randhir S. Multani

Williams Honors College, Honors Research Projects

We tested the hypothesis that daf-12 has the ability to upregulate mir-84 and mir-241 in C. elegans. Rifampicin helps C. elegans live longer by reducing glycation and activating daf-16. It is not clear if daf-12 is needed for this to happen. Daf-16 turns on genes that promote a longer lifespan. Daf-12 increases mir-84 and mir-241 and helps daf-16 become active so it can turn on genes that relate to lifespan. C. elegans were divided into four groups: wild-type, wild-type with RIF, daf-12 RNAi, and daf-12 RNAi with RIF. Worms were incubated at 20°C. An LDH assay and protein assay …

Cognitive Fatigue Detection Using Photoplethysmography (Ppg) And Reaction Time Data, Anhar Sami Mohammed, Prajoy Podder, Maciej Jan Zawodniok, Cihan Dagli

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a framework for real-time cognitive fatigue detection among shift workers using an integrated approach that combines photoplethysmography (PPG) data and reaction time analysis with advanced deep learning models, including Long Short-Term Memory (LSTM) networks and Feedforward Neural Networks (FNNs). The system leverages heart rate variability (HRV) and reaction time data to identify fatigue indicators. The results demonstrate significant performance, with the first FNN model achieving a test accuracy of 98.94% and a loss of 0.2928, while the second FNN model achieved the same accuracy with a slightly higher loss of 0.3089. The LSTM model, designed for sequential …

Guest Editorial, Li Ai, Xiao Tan, Arslan Akbar, Guirong Yan

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

No abstract provided.

Caveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation And Host-Pathogen Interaction, Dibyasri Barman, Rishi Drolia

Biological Sciences Faculty Publications

Within mammalian cells, diverse endocytic mechanisms, including phagocytosis, pinocytosis, and receptor-mediated endocytosis, serve as gateways exploited by many bacterial pathogens and toxins. Among these, caveolae-mediated endocytosis is characterized by lipid-rich caveolae and dimeric caveolin proteins. Caveolae are specialized microdomains on cell surfaces that impact cell signaling. Caveolin proteins facilitate the creation of caveolae and have three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. Many bacterial pathogens hijack caveolin machinery to invade host cells. For example, the Gram-positive facultative model intracellular bacterial pathogen Listeria monocytogenes exploits caveolin-mediated endocytosis for efficient cellular entry, translocation across the intestinal barrier, and cell–cell spread. Caveolin …

Cellular Responses Of Astrangia Poculata (Ellis And Solander, 1786) And Its Symbiont To Experimental Heat Stress, Tyler E. Harman, Daniel Barshis, Briana Hauff Salas, Kevin B. Strychar

Biological Sciences Faculty Publications

Climate change has had devastating effects on tropical coral reefs; however, much less is known regarding how heat stress affects temperate coral. This research focuses on Astrangia poculata (Ellis and Solander, 1786) collected from Narragansett Bay, RI, during the summer and winter seasons and understanding the effect of experimental thermal extremes (i.e., 26 °C) on seasonally different populations. Photosynthetic efficiency (Fv/Fm), symbiont density (via an inverse relationship with pixel intensity), and oxidative stress via reactive oxygen species (ROS) concentrations were measured on symbiotic and aposymbiotic A. poculata. Higher Fv/Fm rates were observed in summer- vs. winter-collected corals (p ≤ …

Impacts Of Tick Parasitism On The Rodent Gut Microbiome, Robert J. Brinkerhoff, Joshua Pandian, Meghan Leber, Isabella D. Hauser, Holly D. Gaff

Biological Sciences Faculty Publications

Host microbiota may impact disease vector behavior and pathogen transmission, but little is known about associations between ectoparasites and microbial communities in wildlife reservoir species. We used Illumina metagenomic sequencing to explore the impacts of tick parasitism on the rodent fecal microbiome in both a field and laboratory setting. We found that tick parasitism on wild hosts was associated with variation in the fecal microbiota of both the white-footed deermouse, Peromyscus leucopus, and the southern cotton rat, Sigmodon hispidus. In a lab experiment, we detected significant changes to the fecal microbiome after experimental exposure to immature ticks in …

Zika Virus Modulates Arthropod Histone Methylation For Its Survival In Mosquito Cells, Telvin Harrell

Biological Sciences Faculty Publications

Zika virus (ZIKV) is a mosquito-borne human pathogen that causes mild febrile illness in adults and severe neurological complications and microcephaly in newborns. Studies have reported that ZIKV modulates methylation of human and viral RNA critical for its replication in vertebrate cells. In this study, we show that ZIKV modulates mosquito S-adenosyl methionine (SAMe)-synthase, an enzyme involved in the production of SAMe (methyl donor), and histone methylation for its survival in mosquito cells. Reverse transcription quantitative PCR followed by immunoblotting analysis showed increased amounts of SAMe synthase at both RNA and protein levels, respectively, in C6/36 mosquito cells infected with …

Speech-Language Pathologists’ Preparation To Become Clinical Educators, Alivia English

Master's Theses and Doctoral Dissertations

Clinical education is significant in a student clinician’s educational journey to prepare them for their career after graduation. It provides the hands-on component that can only be learned and fully understood through performing. The literature regarding students’ experiences in clinical education is vast, but there is a shortage of literature that explores the perceptions of clinical educators (CEs). This thesis consists of three articles. The first article explores the perceptions speech-language pathologists’ have regarding the preparation they received to become CEs, and then the second article takes a look at how the requirements to becoming CEs differ across similar clinical …

Dengue Virus Modulates Critical Cell Cycle Regulatory Proteins In Human Megakaryocyte Cells, Swarnendu Basak, Shovan Dutta, Supreet Khanal, Girish Neelakanta, Hameeda Sultana

Biological Sciences Faculty Publications

Suppression of human megakaryocytes by dengue virus (DENV) infection significantly reduces the platelet count that eventually leads to thrombocytopenia, severe dengue and death. To understand DENV interactions with megakaryocytes, we investigated the cell cycle in leukemic human megakaryocytic in vitro cell line (MEG-01 cells). Megakaryocytes are known for complex endomitotic cell cycle leading to their polyploidy state. Our study shows that DENV uses these polyploid cells for its replication. Understanding the modulation of DENV-mediated cell cycle regulation in megakaryocytes is therefore highly important. We show that DENV2 (serotype 2) infection significantly modulates cell cycle signaling. Our protein profile microarray data …

Addressing The Productivity-Susceptibility Analysis In Data-Limited Fisheries For Understudied Fish In The Marine Aquarium Trade, Alice Wynn, Jemelyn Baldisimo, Gabrielle Baillargeon, Michael Tlusty, Andrew Rhyne

Biological Sciences Faculty Publications

The marine aquarium trade (MAT) harvests millions of coral reef fishes from the wild yearly. While the MAT supports fishers, hobbyists and marine education, harvested fishes are crucial in maintaining coral reef health and balanced marine cycles within their native habitats. Understanding the impact of the MAT on fish populations is critical for sustaining the trade in the long-term. Productivity-susceptibility analyses (PSAs) offer semiquantitative methods of analyzing the productive capacity of each fish stock, as well as its susceptibility to overfishing. The present study revises and expands upon a PSA conducted by Baillargeon et al. (2020) that focused on 32 …

The Role Of Tgf-Beta Superfamily Members In Immune Homeostasis And Disease, Natalie Eva Nieuwenhuizen, Ioannis Eleftherianos, Piotr Jan Kraj, Maria Semitekolou

Biological Sciences Faculty Publications

[Introduction] The Transforming Growth Factor beta (TGF-beta) superfamily, encompassing molecules such as TGFs, activins, Bone Morphogenetic Proteins (BMPs), Growth/Differentiation Factor (GDFs) and Nodals, represents the largest family of growth and differentiation factors, playing crucial roles in developmental and physiological processes across animal species (1). These molecules are integral to tissue homeostasis and cell fate determination. Among them, TGF-beta is particularly noted for its regulatory influence on immune responses and tissue fibrosis (2, 3). Recent research has expanded our understanding of the immune functions of other superfamily members, including activin A and BMPs (4). These molecules signal through receptor complexes composed …

Multi-Locas Gwas Mapping And Candidate Gene Analysis Of Anticancer Peptide Lunasin In Soybean (Glycine Max L. Merr), Rikki Locklear, Jennifer Kusumah, Layla Rashad, Felicia Lugaro, Sonia Viera, Nathan Kipyego, Faith Kipkosgei, Daisy Jerop, Shirley Jacquet, Mythy Addelmajid Kassem, Jiazheng Yuan, Elvira De Mejia, Rouf Mian

Biological Sciences Faculty Publications

Soybean (Glycine max) peptide lunasin exhibits significant cancer-preventive, antioxidant, and hypocholesterolemic effects. This study aimed to identify quantitative trait nucleotides (QTNs) associated with lunasin content and to annotate the candidate genes in the soybean genome. The mapping panel of 144 accessions was gathered from the USDA Soybean Germplasm Collection, encompassing diverse geographical origins and genetic backgrounds, and was genotyped using SoySNP50K iSelect Beadchips. The lunasin content in soybean seeds was measured using the enzyme-linked immunosorbent assay (ELISA) method, with lipid-adjusted soybean flour prepared from seeds obtained from the Germplasm Resource Information Network (GRIN) of USDA-ARS in 2003 and …

Building Heat-Resilient Caribbean Reefs: Integrating Thermal Thresholds And Coral Colonies Selection In Restoration, Macarena Blanco Pimentel, Johanna Calle-Triviño, Daniel J. Barshis, Sancia E. T. Van Der Meij, Megan K. Morikawa

Biological Sciences Faculty Publications

Caribbean reefs face increasingly frequent and intense bleaching events, adding to the numerous other threats impacting these ecosystems. Addressing these challenges requires global action to reduce climate drivers, along with local efforts like reef restoration. Active restoration using thermotolerant coral colonies offers a potential strategy to alleviate these impacts; however, gaps remain in identifying context-specific temperature thresholds to guide colony selection and standardize thermotolerance assessment methods. This study addressed these gaps in two phases. First, by determining practical thresholds to differentiate species responses to heat stress; and second, by developing a framework to identify and prioritize resilient colonies for restoration. …

Herpetofauna Richness, Diversity, And Occurrence At The Northern Ecotone Of Longleaf Pine, Julianne Jones, Dylan Bryant, Erik Yando

Biological Sciences Faculty Publications

Habitat suitability commonly differs between the core and periphery of ecosystems. The longleaf pine ecosystem is recognized for its value in providing habitat to a variety of specialist and endemic species, especially herpetofauna. However, at the northernmost extent of longleaf pine (in southeastern Virginia) little is known about the denizen reptiles and amphibians. Moreover, the remaining longleaf pine ecosystem at the latitudinal ecotone is fragmented amongst a mosaic of other ecosystems. We examined herpetofauna diversity, richness, and capture rates between four focal habitat types—mature longleaf pine, restored longleaf pine, maple-gum swamp, and pocosin-bog—in the Zuni Pine Barrens of southeastern Virginia. …