Digital Commons Network^™

Parp Inhibition Radiosensitizes Brca1 Wildtype And Mutated Breast Cancer To Proton Therapy, Mariam Ben Kacem, Scott J Bright, Emma Moran, David B Flint, David K J Martinus, Broderick X Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C Marinello, Simona F Shaitelman, Gabriel O Sawakuchi

Faculty, Staff and Student Publications

Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons. Protons (9.9 and 3.85 keV/µm) induced higher cell kill independent of BRCA1 status. PARP inhibition amplified the cell kill effect to both photons …

Real-World Safety Profile Of Therapy With Ibrutinib Or Acalabrutinib In Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Ramsay Hafer, Francesco Iadevaia, Thomas Z. Rohan, Teresa Duong, Maria Poluch, Gina Keiffer, Michael Li, Andres Ferber, Luca Laurenti, Alan Khoo, Pierluigi Porcu

Department of Medical Oncology Faculty Papers

No abstract provided.

Extracorporeal Shock Wave Therapy For Children And Adolescents Diagnosed With Osgood Schlatter Disease To Reduce Knee Pain: Systematic Review, Mohammad Tamboosi, Mohammad Tamboosi, Hashim Alharthi, Abdulaziz Bukhari Bukhari, Abdulrahman Alsulami, Waleed Hawari, Yazeed Alahmadi, Rayan Alshahrani, Rayan Alshamrani

Journal of Medical Rehabilitation Science

Aim: The current systematic review aimed to investigate the effectiveness of ESWT on children and adolescents diagnosed with OSD to reduce their knee pain. Method: An electronic search for studies about ESWT on patients with OSD that were published in English in different databases (CINAHL, PubMed, MEDLINE, Scopus, and PEDro). National Heart, Lung, and Blood Institute’s Quality assessment tool was used to evaluate the included studies. Results: According to the search strategy, from 2807 articles, only 2 studies (retrospective cohort and RCT) were selected for the current review, with a total of 34 subjects (20 Males and 14 Females) diagnosed …

Preparedness And Practice Competency In Tracheostomy Management By Speech Language Pathologists In Saudi Arabia, Shabeer A. Abdul Samadh, Muhannad Aljabli

Journal of Medical Rehabilitation Science

The scope of practice by Speech language pathologists in tracheostomy management in patients with or without mechanical ventilation is continuously expanding. Despite this expanding scope, less is known on what is being done throughout the SLPs academic and professional practice in order to achieve competencies and quality practice.

This study aimed to identify the preparations, clinical consistencies and current practice patterns among the Speech language pathologists while treating tracheostomy patients with and without mechanical ventilator within the kingdom of Saudi Arabia. The questionnaire adapted with approval from the authors, Ward et al., (2007, 2008 and 2012) and McGowan et al, …

Impact Of Weight Reduction On Glycemic Control And Glomerular Filtration Rate Among Patients With Type 2 Diabetic Nephropathy, Shehab Mahmoud Abd E-Kader, Shehab Mahmoud Abd E-Kader, Afnan M. Alkhateeb, Saad S. Alfawaz, Umar M. Alabasi, Ziyad A. Neamatallah, Majed Albadi, Moataz Al-Maddah, Ammar Hafez, Riziq Allah Mustafa Gaowgzeh, Salwa R. El-Gendy, Mohamed F. El- Banna, Joud Ahmed Alahmadi, Ahmed M. Aboeleneen

Journal of Medical Rehabilitation Science

Background: Diabetic nephropathy is a microvascular diabetic complication affecting about 40% of diabetic patients all over the world. Objective: This study aimed to measure oxidative stress, systemic inflammation and kidney function response to exercise training in type 2 diabetes mellitus (T2DM) nephropathy patients. Material and Methods: Seventy patients T2DM (42 males and 28 females), body mass index (BMI) mean was 32.96 ± 3.25 Kg/m2and the mean of diabetes chronicity was 13.17 ± 2.18 year and enrolled two groups; group I: practiced aerobic exercise training & diet regimen) and group II: practiced no training or diet regimen intervention. Results: There were …

Lack Of Association Of The Pld4 Snp Rs2841277 With Systemic Sclerosis In A European American Population, Yunqing Ma, Maureen D Mayes, Xinjian Guo, Shervin Assassi, Xiaodong Zhou

Faculty, Staff and Student Publications

This study aimed to examine whether a reported SSc-associated SNP rs2841277 in the PLD4 gene identified in an Asian population was also associated with SSc in European American (EA). The EA cohort consisting of 1005 SSc patients and 961 healthy controls was examined in this study. TaqMan genotyping assays were performed to examine the SNP. Exact P-values were obtained from 2 × 2 tables of allele counts and disease status. In contrast to the previous reports in a Japanese population, SSc patients of EA did not show an association of PLD4 rs2841277 with SSc in general (P = 0.231, OR …

Activity Performance Priorities For Adults Experiencing Homelessness: Insights From Management And Staff At A Transitional Housing Facility, Bernard Austin Kigunda Muriithi

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

For people experiencing homelessness (PEH), the provision of affordable housing has been recognized as the most crucial intervention for improving housing stability and facilitating substance abuse treatment. However, evidence indicates that providing housing does not significantly improve substance abuse, mental health, or physical health outcomes. Optimal participation in essential daily activities has been shown to improve health outcomes and support independent living, but there is limited research that identifies activity performance priorities among PEH living in transitional housing. The present study investigates activity performance priorities using the focus group methodology. Management and staff from a transitional housing facility participated in …

Cancer Organoids As Reliable Disease Models To Drive Clinical Development Of Novel Therapies, Giovanni Blandino, Ronit Satchi-Fainaro, Ingeborg Tinhofer, Giovanni Tonon, Sarah C Heilshorn, Yong-Jun Kwon, Ana Pestana, Carlotta Frascolla, Luca Pompili, Aurora Puce, Sara Iachettini, Annalisa Tocci, Sofia Karkampouna, Marianna Kruithof-De Julio, Piera Tocci, Nicla Porciello, Klizia Maccaroni, Daniela Rutigliano, Xiling Shen, Gennaro Ciliberto

Faculty, Staff and Student Publications

On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including organoids, explants, and engineered or bioprinted systems, have recently emerged as sophisticated tools capable of capturing the complexity and diversity of cancer cells …

Bayesian Semiparametric Inference In Longitudinal Metabolomics Data, Abhra Sarkar, Ornella Cominetti, Ivan Montoliu, Joanne Hosking, Jonathan Pinkney, Francois Pierre Martin, David B. Dunson

Peninsula Medical School

The article is motivated by an application to the EarlyBird cohort study aiming to explore how anthropometrics and clinical and metabolic processes are associated with obesity and glucose control during childhood. There is interest in inferring the relationship between dynamically changing and high-dimensional metabolites and a longitudinal response. Important aspects of the analysis include the selection of the important set of metabolites and the accommodation of missing data in both response and covariate values. With this motivation, we propose a flexible but parsimonious Bayesian semiparametric joint model for the outcome and the covariate generating processes, making novel use of nonparametric …

Mathematical Model Of Control Of A Pumping Unit Used In The Technological Process Of Wastewater Treatment, Nodira Batirdjanovna Alimova Dsc, Professor, Aziza Ruzimamamovna Khaitova

Technical science and innovation

Strict environmental and health regulations, as well as the cost-effectiveness of wastewater treatment processes, have made control technology an important priority in the wastewater treatment industry. Control strategies operate on input variables (setpoint values) by choosing the values they should take to influence the evolution of state variables so that output variables (controllable variables) achieve desired values. The object is a pumping unit used in wastewater treatment technology, and its mathematical model is a set of structures reflecting the characteristics of the simulated processes. The main parameters in mathematical models are temperature and vibration level during pump operation, coordinates of …

Application Of Satellite Interferometry To Tailings Damages To Determine Their Stability, Mukhlisa Khasanovna Rakhimova

Technical science and innovation

In our country and abroad, the construction of special alluvial hydraulic structures - tailings storage facilities - is being carried out on a large scale for storing waste from the mineral enrichment process, the operation of which requires ensuring and observing strict technological control, failure of which leads to serious accidents and even disasters. Tailings dams play a critical role in the mining and metallurgy industry by providing safe storage of production waste. However, their stability and safety are a constant concern. Satellite interferometry (InSAR) is an innovative technology that can effectively monitor deformations and changes in the condition of …

Supporting Holistic Health And Gestational Diabetes Mellitus Risk Reduction Among Young Native Females Prior To Pregnancy: A Qualitative Exploration., Sarah A. Stotz, Luciana E. Hebert, Lisa Scarton, Kelli Begay, Kelly L. Gonzales, Heather Garrow, Melanie Charley, Melanie Aspaas, Denise Charron-Prochownik, Spero M. Manson

OHSU-PSU School of Public Health Faculty Publications and Presentations

AI/AN communities are disproportionately impacted by food insecurity and gestational diabetes mellitus (GDM). Decreasing the risk of GDM can interrupt the intergenerational cycle of diabetes in AI/AN families, and can decrease diabetes-related health disparities. The goal of this study was to explore ways of supporting holistic health and reducing the risk of GDM among young American Indian and Alaska Native (AI/AN) females prior to pregnancy. Semi-structured interviews were conducted with adult AI/AN women (>18 years) who had GDM or who have young female relatives (e.g., daughters) (n = 41), AI/AN females between 12 and 24 years (n = 18), …

Aperiodic Spectral Slope Tracks The Effects Of Brain State On Saliency Responses In The Human Auditory Cortex, Madaline Mocchi, Eleonora Bartoli, John Magnotti, Jan Willem De Gee, Brian Metzger, Bailey Pascuzzi, Raissa Mathura, Suhruthaa Pulapaka, Wayne Goodman, Sameer Sheth, Matthew J Mcginley, Kelly Bijanki

Faculty, Staff and Students Publications

Alteration of responses to salient stimuli occurs in a wide range of brain disorders and may be rooted in pathophysiological brain state dynamics. Specifically, tonic and phasic modes of activity in the reticular activating system (RAS) influence, and are influenced by, salient stimuli, respectively. The RAS influences the spectral characteristics of activity in the neocortex, shifting the balance between low- and high-frequency fluctuations. Aperiodic '1/f slope' has emerged as a promising composite measure of these brain state dynamics. However, the relationship of 1/f slope to state-dependent processes, such as saliency, is less explored, particularly intracranially in humans. Here, we record …

Carboxyl Ester Lipase Hybrid 1 (Cel-Hyb1) Haplotypes Confer Varying Risk For Chronic Pancreatitis, Gergő Berke, Xunjun K Xiao, Mark E Lowe, Et Al.

2020-Current year OA Pubs

The CEL-HYB1 hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene (CELP) has been associated with chronic pancreatitis (CP). Recent work indicated that amino acid positions 488 and 548 in CEL-HYB1 determined pathogenicity. Haplotype Thr488-Ile548 was associated with CP while haplotypes Thr488-Thr548 and Ile488-Thr548 were benign. However, functional analysis revealed that Thr488 is the primary determinant of CEL-HYB1 misfolding and associated endoplasmic reticulum (ER) stress. To address this contradiction, we analyzed a cohort from Hungary and found significantly increased CEL-HYB1 carrier frequency in CP cases (9/319, 2.8%) versus controls (5/618, 0.8%), yielding an odds ratio of 3.6 …

Refinement Of An Algorithm To Detect And Predict Freezing Of Gait In Parkinson Disease Using Wearable Sensors, Allison M Haussler, Lauren E Tueth, David S May, Gammon M Earhart, Pietro Mazzoni

2020-Current year OA Pubs

Freezing of gait (FOG) is a debilitating symptom of Parkinson disease (PD). It is episodic and variable in nature, making assessment difficult. Wearable sensors used in conjunction with specialized algorithms, such as our group's pFOG algorithm, provide objective data to better understand this phenomenon. While these methods are effective at detecting FOG retrospectively, more work is needed. The purpose of this paper is to explore how the existing pFOG algorithm can be refined to improve the detection and prediction of FOG. To accomplish this goal, previously collected data were utilized to assess the prediction ability of the current algorithm, the …

Student National Dental Association Hosts Oral Cancer Walk, Jaycee Cureton

Virginia Dental Journal

The Virginia Commonwealth University’s Student National Dental Association (SNDA) hosted its 12th Annual Oral Cancer Walk on April 16, 2023, to raise awareness and funds for oral cancer research. Proceeds were donated to the Philips Institute for Oral Health Research and included in the VCU School of Dentistry Giving Day fund. Oral cancer, more common in men, is linked to tobacco, alcohol, and HPV, but early detection can significantly reduce mortality. The SNDA, founded in 1970, focuses on supporting minority dental students and improving access to care for underserved communities.

Vda Dental Days At The Capitol Record High Student Turnout, Lakshya Ramani

Virginia Dental Journal

Dental Days at the Capitol 2023, held on January 27, saw a record turnout of students from VCU School of Dentistry. The event, organized by the Virginia Dental Association (VDA), provided students with the opportunity to engage in political advocacy for the first time. Key issues addressed included amending the mental health attestation question on licensure applications and advocating for harsher penalties for violence against healthcare providers. Additionally, the Cosmetic Botox Bill SB 1539, allowing dentists to administer Botox injections, was passed. The event highlighted the importance of student involvement in shaping the future of dentistry.

The Soft Skills Of The Clinical Experience, Michaela Banks

Virginia Dental Journal

Michaela Banks, a Class of 2024 student at VCU School of Dentistry, shares her experiences in developing soft skills during her clinical training. Initially overwhelmed, she found that mastering patient communication and management was more challenging than the technical aspects of dentistry. With guidance from faculty, she learned to effectively communicate treatment plans and reassure anxious patients. By improving her soft skills, she has built trusting relationships with patients, enhanced her time management, and strengthened her empathy, which she believes will benefit her throughout her career.

Through The Looking Glass, Sarah Glass

Virginia Dental Journal

"Through the Looking Glass with Dr. Sarah Glass" explores various cases in oral pathology. It includes the diagnosis of a surgical ciliated cyst in a 51-year-old male with a radiolucent lesion in the mandible, verrucous xanthoma in a 45-year-old male with a growth on his gums, and an adenomatoid odontogenic tumor in an 11-year-old female with an impacted canine. Dr. Sarah Glass, a board-certified Oral and Maxillofacial Pathologist and assistant professor at VCU School of Dentistry, provides insights into these conditions.

A Partnership With Special Olympics, Organized Dentistry, The Community, And Two Dental Schools, Phillip Ashkar

Virginia Dental Journal

The document discusses a partnership involving Special Olympics, organized dentistry, the community, and two dental schools to address the oral health disparities faced by individuals with special needs, particularly those with Intellectual or Developmental Disabilities (IDD). It highlights the challenges these individuals face in accessing appropriate dental care due to a lack of specialized resources and providers. The partnership's efforts include providing free dental services through events like the one held on June 10, 2023, where dental students and professionals offered comprehensive care to underserved populations. Despite these efforts, the document emphasizes the ongoing need for systemic changes to improve …

Answering Your Frequent Delta Dental Questions, Brad Guyton

Virginia Dental Journal

Delta Dental of Virginia (DDVA) is part of the national Delta Dental Plans Association, serving over two million members and 5,000 employer groups in Virginia. DDVA processes over four million dental claims annually and handles numerous inquiries from dentists. Claims for out-of-state patients are processed using a National Provider File system to ensure correct fee arrangements. Participating in DDVA's network offers access to a large population of insured patients, though fee amounts are regularly evaluated to remain competitive. Fee increases were implemented in 2021 and 2023, with another anticipated in January 2024.

Our Regional Workforce Needs, Paul Logan

Virginia Dental Journal

The Virginia Dental Workforce Council, led by VDA President Dr. Cindy Southern, is addressing regional imbalances in the dental workforce, particularly in Northern Virginia and Richmond. The council emphasizes the need for state resources and local partnerships to make it easier for dentists to practice in underserved areas. Despite challenges, Virginia saw an increase in licensed dental hygienists in 2022. Efforts include supporting dental programs, recruiting faculty, aiding student retention, and advocating for flexible accreditation standards. The council aims to improve oral health across Virginia through collaboration and innovative solutions.

Reusing And Adapting Marketing Content To Make Your Life Easier, Michaela Mishoe

Virginia Dental Journal

Creating an efficient, long-term content plan for your dental practice's marketing can save time and effort. Key strategies include using an editorial calendar to plan content around important dates, building a bank of photos, quotes, and testimonials, and recycling content by slicing it into smaller pieces for various platforms. Tools like Google Sheets, Canva, and third-party content from organizations like the ADA can help streamline the process. This approach ensures consistent, strategic, and creative content aligned with your marketing goals.

Virginia Board Of Dentistry Notes June 16, 2023, Richard F. Roadcap Dds

Virginia Dental Journal

The Virginia Board of Dentistry met on June 16, 2023, to discuss various topics, including the approval of previous meeting minutes, workforce needs, and infection control training for dental assistants. The Board reviewed the Dentist and Dental Hygienist Compact, with members expressing concerns and opposition. They also discussed new regulations allowing general dentists to administer Botox for cosmetic purposes, with an 18-month timeline for development. The meeting concluded with acknowledgments of Dr. Bryant's service as Board President and a call to investigate the impact of Artificial Intelligence and ChatGPT on dental practice.

Cosmetic Botox Administration In The Dental Office: Risk Management & Insurance Considerations, Andrew Gerner

Virginia Dental Journal

Virginia dentists can now legally administer Botox for cosmetic purposes under SB 1539, but they must complete specific training and continuing education as mandated by the Board of Dentistry. As of now, these requirements have not been published. Dentists should also consult with their malpractice insurance providers to ensure coverage for Botox procedures, as some insurers may not cover these services or may require additional premiums. It is crucial for dentists to consider regulatory compliance, risk management, and insurance implications before offering Botox treatments.

Automated Insurance Verification Can Improve Patient Satisfaction And Revenue, Robert Mcdermott

Virginia Dental Journal

Automated insurance verification can significantly enhance patient satisfaction and boost revenue for dental practices. By providing clear and transparent billing information, reducing administrative burdens, and preventing unexpected costs, this technology improves communication and efficiency. It ensures patients are well-informed about their coverage and out-of-pocket expenses, leading to better patient experiences and increased practice profitability.

Ethics: Informed Consent, Adel Rizkalla Dds

Virginia Dental Journal

Informed consent in dental practice involves clear communication between dentists and patients about treatment risks, benefits, costs, and outcomes. It is rooted in the patient's right to self-determination and requires the dentist to present information objectively and holistically. Ethical practice demands that treatment recommendations should not be influenced by financial pressures or personal gain but should focus on the patient's best interests. Effective informed consent enhances the patient-clinician relationship and supports ethical decision-making in dental care.

Understanding Social Security, Bobby Moyer

Virginia Dental Journal

Most Americans rely on Social Security for retirement support, but understanding when to start benefits is crucial. Claiming benefits early at age 62 reduces the overall amount, while delaying increases it by 8% annually. Factors like health, life expectancy, and income needs should influence the decision. Full benefits are available at ages 66-67. Widows, widowers, and divorced individuals may have additional benefit options. Consulting with an advisor is recommended to optimize benefits and ensure a successful retirement plan.

Vda Pac Fundraiser For Senator Todd Pillion, Laura Givens

Virginia Dental Journal

The document summarizes the fundraiser for Senator Todd Pillion organized by the VDA PAC.

Ada Dentist And Student Lobby Day, Laura Givens

Virginia Dental Journal

Document overview: The document discusses the participation of dentists and dental students in advocacy efforts and lobby days in Washington D.C.