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Speculations On Brunelleschi’S Pazzi Chapel, Howard A. Risatti Professor Emeritus, Donald Schrader Dec 2024

Speculations On Brunelleschi’S Pazzi Chapel, Howard A. Risatti Professor Emeritus, Donald Schrader

Art Inquiries

Why speculate on Filippo Brunelleschi’s Pazzi Chapel? As Giorgio Vasari wrote, many of Brunelleschi’s projects were not finished in his lifetime and not as he wished. The lesson to be drawn, says Vasari, who was writing a century after Brunelleschi’s death, is that “anyone who wishes to leave a memorial of his existence should complete it in his own lifetime and not put faith in anyone else.” Since Brunelleschi died well before the chapel was completed, issues have been raised for over a century about its inconsistencies regarding the open loggia, the barrel-vaulted portico, and the façade. This paper addresses …


Art Inquiries, Xix:1, Full Issue, Mysoon Rizk Dec 2024

Art Inquiries, Xix:1, Full Issue, Mysoon Rizk

Art Inquiries

No abstract provided.


Institutional Support's Influence On Green Beekeeping Adoption In Resource-Constrained Biharamulo Forest Reserve, Tanzania: The Extended Theory Of Planned Behavior, Haruna Athumani, Ranger Kanan, Gerald Zachary Paga Tinali Dec 2024

Institutional Support's Influence On Green Beekeeping Adoption In Resource-Constrained Biharamulo Forest Reserve, Tanzania: The Extended Theory Of Planned Behavior, Haruna Athumani, Ranger Kanan, Gerald Zachary Paga Tinali

Business Management Review

Green production practices are crucial for environmental conservation, yet scholarly research on green beekeeping remains limited. This study seeks to enhance the Theory of Planned Behavior (TPB) by developing an extended model of Institutional Support theory of Planned Behavior (ISTPB) to understand better beekeepers' behavior toward adopting green beekeeping practices. The model focuses on institutional support and its role in shaping individual behavior related to green beekeeping adoption. Using structural equation modeling (SEM), the study's empirical results show that institutional support and the three original TPB components, i.e., attitude, subjective norms, and perceived behavioral control, positively and significantly influence green …


Short-Term Parental Migration And Intergenerational Educational Persistence, Swati Sharma Dec 2024

Short-Term Parental Migration And Intergenerational Educational Persistence, Swati Sharma

Asia-Pacific Social Science Review

This study examines the mechanisms through which short-term parental migration affects intergenerational educational persistence, using a sample of 40,922 Indian father-child pairs from the Indian Human Development Surveys. A flexible modeling approach was used that allows for heterogeneous effects of social origins and structural features of the Indian education system on different educational transitions of the child. Results show that parental migration increases intergenerational educational persistence. In particular, persistence increases for higher educational transitions when parental migration is motivated by economic distress or when the left-behind children are engaged in household responsibilities. Lack of parental supervision increases persistence across all …


Should The Philippines Shift To The Opt-Out System?, Napoleon Mabaquiao Jr., Ronel De Loyola Dec 2024

Should The Philippines Shift To The Opt-Out System?, Napoleon Mabaquiao Jr., Ronel De Loyola

Asia-Pacific Social Science Review

With the increasing demand for organs and the shortage of organ donations, more lives are being lost every day. Governments and national health authorities are, consequently, exploring more effective ways to increase organ donation rates, both from the living and the dead. Regarding cadaveric organ donations, the increase in organ donation rates in countries that have shifted from the opt-in (or explicit consent) system to the opt-out (or presumed consent) system has been very encouraging. As a result, some other countries still operating under the opt-in system are contemplating making the same move. In the Philippines, there are bills filed …


The Implementation Of Behaviour Change Practices In Physical Activity Referral Schemes: A Narrative Review, John Downey, Katie Shearn, Nicola Brown, Ross Wadey, Jeff Breckon Dec 2024

The Implementation Of Behaviour Change Practices In Physical Activity Referral Schemes: A Narrative Review, John Downey, Katie Shearn, Nicola Brown, Ross Wadey, Jeff Breckon

School of Nursing and Midwifery

BackgroundPhysical activity referral schemes have been used extensively as one pathway to support behaviour change in people with long term conditions. Best practice guidance, across countries, recommend that schemes use behaviour change practices. The effectiveness of these schemes is inconsistent, yet, little is known about the implementation of specific approaches, or what influences practitioner’s delivery. This article provides a narrative review of evidence exploring the implementation of behaviour change practices in physical activity referral schemes.MethodsAn electronic search of three databases (PubMed, Scopus, Google Scholar) was undertaken. A menu of iterative techniques was also applied from the CLUSTER approach to increase …


A Growing Concern: Long Commutes And Mental Fatigue Among Workers, Dayana Hazwani Mohd Suadi Nata, Putri Anis Syahira Mohamad Jamil, Mira Nursabrina Muhammad Rawee Dec 2024

A Growing Concern: Long Commutes And Mental Fatigue Among Workers, Dayana Hazwani Mohd Suadi Nata, Putri Anis Syahira Mohamad Jamil, Mira Nursabrina Muhammad Rawee

Makara Journal of Health Research

Background: Commuting stress is a growing concern for workers with long daily journeys between home and work. This study explores the effects of commuting on workers’ mental and physical health, focusing on stress, mental fatigue, and productivity at work.

Methods: The research conducted in Selangor, Malaysia, involved 212 commuters who completed a survey that included sociodemographic and commuting information, the Depression Anxiety and Stress Score (DASS-21), and a mental fatigue questionnaire.

Results: The findings revealed that a significant proportion of workers experienced stress from their commuting routines: approximately 74.5% reported that commuting had a detrimental effect on …


Association Between Knowledge, Attitude, And Practice On Dietary Fiber Intake And Body Mass Index Among Undergraduate Students In Universiti Kebangsaan Malaysia, Arimi Fitri Mat Ludin, Munirah Ismail, Mohd Sham Othman, Divya Vanoh, Chai Huoy Tyng, Irdina Ibrahim, Jasmine Lavang Surang, Muhammad Adam Jayiddin, Noor Afiifah Ibrahim, Nur Arina Shazrina Abdullah, Nur Athirah Harun, Nur Fatihah Rashidi, Lew Leong Chen Dec 2024

Association Between Knowledge, Attitude, And Practice On Dietary Fiber Intake And Body Mass Index Among Undergraduate Students In Universiti Kebangsaan Malaysia, Arimi Fitri Mat Ludin, Munirah Ismail, Mohd Sham Othman, Divya Vanoh, Chai Huoy Tyng, Irdina Ibrahim, Jasmine Lavang Surang, Muhammad Adam Jayiddin, Noor Afiifah Ibrahim, Nur Arina Shazrina Abdullah, Nur Athirah Harun, Nur Fatihah Rashidi, Lew Leong Chen

Makara Journal of Health Research

Background: A fiber-rich diet lowers the risk of various diseases by increasing fecal bulk, shortening intestinal transit time, and stimulating intestinal flora. This study examines the association between knowledge, attitude, and practice (KAP) regarding dietary fiber intake and body mass index (BMI) among Dentistry and Software Engineering undergraduates.

Methods: This cross-sectional study included 95 Dentistry and 92 Software Engineering students at the Universiti Kebangsaan Malaysia. The KAP questionnaire was analyzed for its reliability using Cronbach’s alpha and distributed through email.

Results: Most respondents had normal weight. The Software Engineering students had a higher percentage of overweight and …


Threat Of Hypercholesterolemia In Urban Adults And Its Associates: Evidence From A Community-Based Study, Ambika Rani Yadav, Priya Keshari Dec 2024

Threat Of Hypercholesterolemia In Urban Adults And Its Associates: Evidence From A Community-Based Study, Ambika Rani Yadav, Priya Keshari

Makara Journal of Health Research

Background: Hypercholesterolemia is an abnormality of lipids. It is a crucial modifiable risk factor for cardiovascular diseases. There is a paucity of community-based studies on hypercholesterolemia in the adult population in India. Given this context, the study aims to assess the prevalence and spectrum of hypercholesterolemia, along with its associated factors, among adult residents of urban areas in Prayagraj district, Uttar Pradesh, India.

Methods: This community-based cross-sectional study was done on 536 urban adult subjects (30 to 59 years) of Prayagraj, India, selected by multistage sampling procedure. The predesigned and pretested interview schedule was used to obtain socio-demographic …


Investigation Of The Relationship Between Nursing Students’ Ethical Sensitivities And Care Behaviors, Pınar Yel, Neriman Zengin, Aysenur Çetin Üçeriz Dec 2024

Investigation Of The Relationship Between Nursing Students’ Ethical Sensitivities And Care Behaviors, Pınar Yel, Neriman Zengin, Aysenur Çetin Üçeriz

Makara Journal of Health Research

Background: Care encompassing ethical and legal aspects is essential for nursing and involves actions that aim to improve individual well-being. In this study, we assessed the relationship between nursing students’ ethical sensitivity and care behaviors.

Methods: This descriptive study included 191 students enrolled at a foundation university who consented to participate. Relevant data were gathered by using the Descriptive Information Form, Ethical Sensitivity Scale Adapted for Nursing Students, and Caring Behaviors Scale-24. Surveys were conducted face-to-face with the attending students and via Google Forms for the non-attending students.

Results: The mean total score of the ethical sensitivity …


Health Literacy Of Unhealthy Diet Consumption In Thailand, Sitaporn Suriya, Buraskorn Torut Dec 2024

Health Literacy Of Unhealthy Diet Consumption In Thailand, Sitaporn Suriya, Buraskorn Torut

Makara Journal of Health Research

Background: The burden of noncommunicable diseases (NCDs) is increasing worldwide, including in Thailand. One risk factor for NCDs is an unhealthy diet. Thus, this study aimed to investigate the factors affecting the consumption of an unhealthy diet and determine the proactive policies that support factors inhibiting an unhealthy diet.

Methods: We investigated the factors affecting unhealthy diet consumption behavior by multiple linear regression analysis by surveying 970 Thai patients with early-stage NCD. In addition, we investigated appropriate policy proposals by conducting in-depth interviews with 20 key informants.

Results: Knowledge (−0.247, 95% confidence interval (CI) −0.285 to −0.210), …


The Impact Of Immigrants On The Number And Type Of Births, Neset Gumusburun, Ergun Mendes Dec 2024

The Impact Of Immigrants On The Number And Type Of Births, Neset Gumusburun, Ergun Mendes

Makara Journal of Health Research

Background: Although cesarean section is a life-saving procedure in certain situations, it may result in complications for maternal and infant health when conducted, especially for nonmedical purposes. The civil war in Syria has significantly modified the demographic and ethnic structure of Turkey, which has affected the number and type of births occurring here. In this study, we aimed to determine the effect of the increasing Syrian refugee patient population on primary cesarean section rates in Kilis/Turkey.

Methods: In this retrospective cohort study, pregnant women who gave birth at the State Hospital in the Kilis province in Turkiye between …


The Association Between Sleep Quality, Depression, Anxiety, And Job-Related Stress Among Nurses In Saudi Arabia, Romeo Jr Patague Mostoles Dec 2024

The Association Between Sleep Quality, Depression, Anxiety, And Job-Related Stress Among Nurses In Saudi Arabia, Romeo Jr Patague Mostoles

Makara Journal of Health Research

Background: This study examined the mediating role of sleep quality in the relationship between depression, anxiety, and job-related stress among nurses in Saudi Arabia.

Methods: Sociodemographic information, Pittsburgh Sleep Quality Index, depression, anxiety, and work-related stress were evaluated in 851 nurses. Structural equation modeling was used to investigate the mediation effect of sleep quality on mental health and job stress in nurses.

Results: High rates of anxiety (65.9% severe, 34.1% moderate), depression (37.2% moderate to severe), and poor sleep (51.4%) were found. Sex, marital status, education, nationality, and smoking status significantly influenced mental health outcomes. For example, …


Nurses’ Empathy, Burnout, And Contentment With Life In Turkey, Sevinç Mersin, Özlem İbrahimoğlu, Merve Tuncer, Ali Arslanoğlu Dec 2024

Nurses’ Empathy, Burnout, And Contentment With Life In Turkey, Sevinç Mersin, Özlem İbrahimoğlu, Merve Tuncer, Ali Arslanoğlu

Makara Journal of Health Research

Background: Empathy has various consequences for nurses. Therefore, its effects on nurses should be identified. Thus, this study aimed to determine the relationships between empathy, burnout, and level of contentment with life in nurses and the characteristics that affect them.

Methods: This descriptive–correlational study was conducted on 653 nurses in Turkey between November and December 2021. Data were collected using an information form, the Basic Empathy Scale, Burnout Measure Short Scale, and Contentment with Life Assessment Scale.

Results: A positive, weak, and significant relationship was noted between the mean Basic Empathy Scale and Burnout Measure Scale scores. …


Psychological Effects Of Number Of Knee Surgeries In Female Collegiate Soccer Athletes, Jun Yamada, Eric G. Post Dec 2024

Psychological Effects Of Number Of Knee Surgeries In Female Collegiate Soccer Athletes, Jun Yamada, Eric G. Post

Clinical Practice in Athletic Training

Psychological readiness is an important factor for returning to sport successfully following anterior cruciate ligament (ACL) reconstruction. To date, no studies have determined the effect of the number of knee surgery to psychological readiness. The primary purpose of this investigation was to determine whether the number of knee surgeries impacts psychological readiness. The secondary purpose was to examine the relationship between the number of surgeries and knee function. Data was collected from participants on the women’s soccer teams at a local division Ⅰ, Ⅲ, and NAIA college. Inclusion criteria were 1) currently fully participating in activities without any limitations, and …


Treating Chronic Low Back Pain And Plantar Fasciitis With Myokinesthetic System: A Case Study, Sadie Buboltz-Dubs, Russell Baker Dec 2024

Treating Chronic Low Back Pain And Plantar Fasciitis With Myokinesthetic System: A Case Study, Sadie Buboltz-Dubs, Russell Baker

Clinical Practice in Athletic Training

The purpose of this case study was to report the effects of the MyoKinesthetic (MYK) System on the pain and function of a collegiate softball player previously diagnosed with chronic non-specific low back pain and foot pain. The patient had been experiencing bilateral foot pain since childhood and conservative treatment options had failed to resolve her pain long term. Additionally, the patient had been experiencing persistent back tightness and soreness. Upon arrival at the university, the patient was evaluated using the MYK postural analysis to identify if a primary nerve root dysfunction could be the cause of her pain. The …


Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Raquel Puerta, Amanda Cano, Pablo García-González, Fernando García-Gutiérrez, Maria Capdevila, Itziar De Rojas, Clàudia Olivé, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Carlos Cruchaga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz Dec 2024

Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Raquel Puerta, Amanda Cano, Pablo García-González, Fernando García-Gutiérrez, Maria Capdevila, Itziar De Rojas, Clàudia Olivé, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Carlos Cruchaga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz

Faculty, Staff and Student Publications

High-throughput proteomic platforms are crucial to identify novel Alzheimer’s disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan® 7k) and antibody-based (Olink® Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan® assays analyzing the same samples, and between SomaScan® and Olink® results. Association analyses were performed between proteomic measures, CSF biological traits, sample demographics, and AD endophenotypes. Our 12-category metric of reproducibility combining correlation analyses identified 2428 highly reproducible SomaScan CSF measures, …


Contents Of Vol. 31, No.3, December 2024, Yuniardini Wimardhani Dec 2024

Contents Of Vol. 31, No.3, December 2024, Yuniardini Wimardhani

Journal of Dentistry Indonesia

This is contents of Vol. 3 2024, December 2024


Road To Progress Or Bumpy Detour? Jeepney Drivers’ Lived Experiences Amidst Ongoing Phaseout, Reignchielle Jcynd D. Lacsina, Ivan Karlo S. Pating, Marjorie L. Paloma, Joy F. Galleon Dec 2024

Road To Progress Or Bumpy Detour? Jeepney Drivers’ Lived Experiences Amidst Ongoing Phaseout, Reignchielle Jcynd D. Lacsina, Ivan Karlo S. Pating, Marjorie L. Paloma, Joy F. Galleon

Sinaya: A Philippine Journal for Senior High School Teachers and Students

This study utilizes a phenomenological research design to explore the lived experiences of jeepney drivers amidst the ongoing government’s initiative to phase out and modernize traditional jeepneys in the Philippines. It focused on six jeepney drivers operating in the Tarlac public transportation system, selected based on specific inclusion criteria. The Theory of Change was used to delve deeper into the findings, revealing that the government's initiatives have challenged the stability of jeepney drivers’ livelihood during the modernization transition. Their lives were in jeopardy due to this abrupt transformation. It left them powerless to adapt to the changes or boycott. The …


The Reel Narrative: The Portrayal And Consequent Archetypes Of Women In Selected Mainstream Philippine Romantic Cinema, Ma. Beatrice P. Pilar, Nathaniel Rey D. Ferrer Dec 2024

The Reel Narrative: The Portrayal And Consequent Archetypes Of Women In Selected Mainstream Philippine Romantic Cinema, Ma. Beatrice P. Pilar, Nathaniel Rey D. Ferrer

Sinaya: A Philippine Journal for Senior High School Teachers and Students

In Philippine society, media, particularly romance films, shapes and reinforces audiences’ perspectives, perpetuating preconceived notions and stereotypical beliefs. However, there is a lack of textual analysis within Filipino films, especially regarding female representation in media. Hence, our study explores the portrayal of female main characters in romance films. Textual film analysis, grounded in Carl Jung’s Jungian archetypes and Jean Shinoda Bolen’s female archetypes in media, was implemented on the six Filipino highest-grossing romance films from 2014 until 2019. This analysis, further supported by a feminist lens, aimed to identify the character portrayal and archetypes of the main female characters in …


What Is Deeply Rooted In The Constitution?, Thomas P. Crocker Dec 2024

What Is Deeply Rooted In The Constitution?, Thomas P. Crocker

BYU Law Review

In a series of cases stretching over a century, the Court made a right’s roots a constitutive feature of its identity. Highlighting the analytic centrality of deep roots to the recognition of rights, Dobbs v. Jackson Women’s Health withdrew prior judicial recognition of a woman’s right to reproductive choice, arguing that such a right was not properly rooted in the American legal tradition. But what does it mean for a right to have deep roots? A surprising feature of American constitutionalism is that there is no single answer to the basic analytic question of what it means for a right …


Is An Autonomous Vehicle A Roller Coaster Or A Hollywood Film? Trust, Safety, And Industry Self-Regulation, Tracy Hresko Pearl Dec 2024

Is An Autonomous Vehicle A Roller Coaster Or A Hollywood Film? Trust, Safety, And Industry Self-Regulation, Tracy Hresko Pearl

BYU Law Review

Regulation of autonomous vehicles continues to be a daunting task in the United States, and the federal government has not yet succeeded in creating a regulatory scheme that intelligently addresses the risks and benefits of these vehicles. There are multiple reasons for this regulatory lag. Autonomous vehicles are developing at such a rapid pace that lawmakers, who often struggle with technological literacy, struggle to keep up. Additionally, government agencies lack the level of expertise, experience, and data that the industry possesses.

Industry self-regulation offers a meaningful alternative for increasing the safety of autonomous vehicles and building consumer trust. The success …


Into The Sunset: Divorcing Families Need Their Slice Of The Tcja Reversions, John C. Mcdonald Dec 2024

Into The Sunset: Divorcing Families Need Their Slice Of The Tcja Reversions, John C. Mcdonald

BYU Law Review

On its path to sufficiently offsetting its major cut to the corporate income tax rate in 2017, Congress turned to a surprising source for funds: the alimony support payments of recently divorced families. Alimony’s inclusion/deduction regime in §§ 71 and 215 of the Code allowed divorcing couples to reach mutually beneficial divorce agreements for over half a century until it was unceremoniously repealed by the Tax Cuts and Jobs Act of 2017 with a striking lack of satisfying legislative justifications. This Note suggests that in evaluating the impact of the repeal, Congress and others have failed to consider an important …


Nutritional Support Leading To The Accomplishment Of Treatment Goal: A Case Report Of Recurrent Locally Advanced Breast Cancer, Panuch Eiamprapaporn, Kanokkarn Chupisanyarote Dec 2024

Nutritional Support Leading To The Accomplishment Of Treatment Goal: A Case Report Of Recurrent Locally Advanced Breast Cancer, Panuch Eiamprapaporn, Kanokkarn Chupisanyarote

Asian Medical Journal and Alternative Medicine

A 56-year-old woman with recurrent locally advanced breast cancer (rcT1a N3a M0, Luminal B) underwent curative intent treatment. Oral nutritional support (ONS), which was an immune-nutrition formula, was implemented to optimize her nutritional status and support treatment tolerance. This case highlights the importance of nutritional support in improving treatment outcomes for patients with recurrent breast cancer.


Supporting Mental Wellness In Transgender Athletes, Abaigeal C. Fields, Zachary K. Winkelmann Dec 2024

Supporting Mental Wellness In Transgender Athletes, Abaigeal C. Fields, Zachary K. Winkelmann

Clinical Practice in Athletic Training

N/a


A Review Of Automated External Defibrillator Considerations In Athletic Training, Bryana M. Mammana, Susan W. Yeargin, Zachary K. Winkelmann Dec 2024

A Review Of Automated External Defibrillator Considerations In Athletic Training, Bryana M. Mammana, Susan W. Yeargin, Zachary K. Winkelmann

Clinical Practice in Athletic Training

N/a


Correlation Between Pre-Season Single-Leg Hop Testing Data And Lower Extremity Injuries In Collegiate Soccer Players, Ashley Kuchenbuch, Justin M. Stanek Dec 2024

Correlation Between Pre-Season Single-Leg Hop Testing Data And Lower Extremity Injuries In Collegiate Soccer Players, Ashley Kuchenbuch, Justin M. Stanek

Clinical Practice in Athletic Training

Lower extremity injuries are very common in collegiate soccer athletes and often lead to long-term rehabilitation programs and a decline in the athlete’s overall quality of life. Using single leg hop tests to identify “at-risk” athletes before the competitive season begins could allow medical staff to implement injury prevention programs that could help reduce the incidence of lower extremity injuries throughout the season. The purpose of this study was to determine if data taken from single leg hop (SLH) testing could help predict lower extremity injuries in female collegiate soccer players. A convenience sample of twenty-one participants were chosen to …


Biological Aging Pathways That Underlie Life Course Socioeconomic Disparities In Physical Function And Longevity, Tara Gruenewald, Naomi Podber Dec 2024

Biological Aging Pathways That Underlie Life Course Socioeconomic Disparities In Physical Function And Longevity, Tara Gruenewald, Naomi Podber

Psychology Faculty Articles and Research

The poorer functioning and greater morbidity and mortality risk in those with greater life course socioeconomic disadvantage has led to the search for the biological processes that underlie these associations, including accelerated cellular and system aging. Our study examines whether a DNA methylation profile of the pace of biological aging (DunedinPACE) and a multi-system index of physiological dysregulation (allostatic load (AL)) mediate associations between life course socioeconomic disadvantage (SESDIS) and both physical function (gait speed, chair stand time) and survival. Data are from the Midlife in the U.S. Study (N=1,295, age 26–86, 55.4% female, 69.0% white). Measures included a multi-indicator …


Linking Transcriptome And Morphology In Bone Cells At Cellular Resolution With Generative Ai, Lu Lu, Noriaki Ono, Joshua D Welch Dec 2024

Linking Transcriptome And Morphology In Bone Cells At Cellular Resolution With Generative Ai, Lu Lu, Noriaki Ono, Joshua D Welch

Faculty, Staff and Student Publications

Recent advancements in deep learning (DL) have revolutionized the capability of artificial intelligence (AI) by enabling the analysis of large-scale, complex datasets that are difficult for humans to interpret. However, large amounts of high-quality data are required to train such generative AI models successfully. With the rapid commercialization of single-cell sequencing and spatial transcriptomics platforms, the field is increasingly producing large-scale datasets such as histological images, single-cell molecular data, and spatial transcriptomic data. These molecular and morphological datasets parallel the multimodal text and image data used to train highly successful generative AI models for natural language processing and computer vision. …


Dynamic And Concordance-Assisted Learning For Risk Stratification With Application To Alzheimer’S Disease, Wen Li, Ruosha Li, Ziding Feng, Jing Ning Dec 2024

Dynamic And Concordance-Assisted Learning For Risk Stratification With Application To Alzheimer’S Disease, Wen Li, Ruosha Li, Ziding Feng, Jing Ning

Faculty, Staff and Student Publications

Dynamic prediction models capable of retaining accuracy by evolving over time could play a significant role for monitoring disease progression in clinical practice. In biomedical studies with long-term follow up, participants are often monitored through periodic clinical visits with repeat measurements until an occurrence of the event of interest (e.g. disease onset) or the study end. Acknowledging the dynamic nature of disease risk and clinical information contained in the longitudinal markers, we propose an innovative concordance-assisted learning algorithm to derive a real-time risk stratification score. The proposed approach bypasses the need to fit regression models, such as joint models of …