Digital Commons Network^™

Neuropsychological Assessment Accuracy In Diagnosing Early-Onset Alzheimer’S Disease, Elise Thomas

Master's Theses and Doctoral Dissertations

Early-onset Alzheimer’s disease (EOAD), a progressive neurological condition, is often difficult to diagnose before substantial neuronal damage. Neuropsychological assessments offer a more cost-effective and accessible method for detecting early cognitive decline, yet limited research exists on optimal combinations for EOAD identification. This study analyzed data from 24 clinical studies to determine the diagnostic accuracy of FDA-approved EOAD assessments used in combination. No single combination was found to be superior across all diagnostic metrics. MMSE + MoCA + ADAS-Cog showed the highest sensitivity, MMSE + MoCA + RBANS the highest specificity, MMSE + RBANS the highest AUC value, and MMSE + …

Evaluating Educational Bias In Executive Function Assessments: A Comparison Of Reacstick And The Nih Toolbox In Individuals With Multiple Sclerosis, Maura Lane

Master's Theses and Doctoral Dissertations

This study investigated the influence of educational attainment on executive function performance across two cognitive assessment tools—ReacStick (RS) and the National Institute of Health Cognition Toolbox Cognition Battery (NIH Toolbox-CB)— in individuals with multiple sclerosis (MS). Participants with confirmed MS diagnoses completed both cognitive assessment tools, and the correlation between years of education and task performance was analyzed to evaluate the presence of educational bias. Results showed that NIH Toolbox-CB scores were significantly associated with education level, whereas RS parameters did not demonstrate this relationship. These findings suggest that RS performance may be less influenced by educational background and could …

From Equitable Access To Equitable Usage: Moving Towards Data-Driven, Evidence-Based Cycling Assets Management, Kewei Ren, Yunping Liang, Chun-Hsing Ho

Durham School of Architectural Engineering and Construction: Faculty Publications

Cycling is increasingly recognized for its wide range economic, environmental, and health benefits as a mobility option. However, disparities in the provision and the quality of bicycle infrastructure persists. Ensuring fair access and usage of these benefits for all presents a significant challenge. As a result, establishing effective methodologies to evaluate cycling equity is critically important. This paper synthesizes research on infrastructure asset management with a focus on equity considerations in bicycle infrastructure. A systematic review of 19 North American studies critically examines how existing research categorizes vulnerable populations and assesses fairness. The results reveal that most existing analyses focus …

Quality Improvement Project: Implementing A Standardized, Structured Preceptor Program For Licensed Nurses In The Ambulatory Care Setting To Improve Preceptor Competence Level, Sibil J. Blee

Doctor of Nursing Practice Projects

Ambulatory care settings demand diverse nursing skills, making effective preceptorship crucial for successful new nurse transitions. However, many preceptors lack formal preceptor training. This quality improvement project implemented and evaluated a structured preceptor training program for licensed nurses in a large metropolitan healthcare system in Southeast Texas, addressing this critical gap. The project, informed by best practices from acute care and the American Academy of Ambulatory Care Nursing’s Preceptor Guide, explored the impact of structured training on ambulatory care nurse competence within eight weeks, compared to no training. Fourteen nurses voluntarily participated, with twelve (85.7%) completing pre- and post-intervention surveys. …

Quality Improvement Project: Empowering Nursing Instructors For Effective Simulation Facilitation, Brittany N. Hilson

Doctor of Nursing Practice Projects

Simulation-based education is vital in nursing education, enhancing clinical skills and decision-making in a controlled environment. The DNP Quality Improvement (QI) project aimed to increase nursing faculty self-efficacy in facilitating simulation-based education by providing targeted training in high-fidelity simulation technology. A needs assessment at the school of nursing project site revealed that the faculty lacked sufficient experience and confidence in using simulation equipment. The impact of the simulation-based intervention was evaluated by applying a paired sample t-test, utilizing pre- and post-assessment data. Following a four-week intervention, the results demonstrated that 69.2% of participants showed a significant increase in self-efficacy, with …

The Association Between Medication Adherence, Internalized Stigma And Social Support Among Outpatients With Major Depressive Disorder In A Malaysian Hospital: A Cross-Sectional Study, Martha Sajatovic

Faculty Scholarship

Background: Internalized stigma and medication non-adherence pose significant challenges for treating major depressive disorder (MDD), leading to disability, increased suicide risk, and morbidity. Limited data exists on modifiable factors associated with adherence in lower-resourced settings like Malaysia. This study aimed to investigate poor adherence prevalence and the demographic and clinical factors associated with poor medication adherence among patients with MDD. Methods: This cross-sectional survey recruited participants using universal sampling from a major hospital in Selangor, Malaysia. Participants answered questionnaires consisting of demographic and clinical information (medical history, duration of anti-depressant treatment for MDD, psychiatric ward admission history, and any medication …

Southern Adventist University Adult Degree Completion Catalog 2024-2025, Southern Adventist University

Catalog, Adult Degree Completion

Southern Adventist University's adult degree completion catalog for the academic year 2024-2025.

Introducing A Paper Communication Alternative For Emergency Department Nurse-Technician Delegation To Promote Workflow Efficiency: A Quality Improvement Project, Grant Quinn

Master's Theses and Capstones

Background: Efficient and high quality communication is paramount in the emergency department setting, especially between registered nurses (RNs) and emergency department technicians. In a fluid and high-octane microsystem, poor communication can lead to missed or delayed delegated tasks, which harm teamwork and patient safety and outcomes.

Purpose: By introducing a low-cost, paper-based communication alternative to this microsystem into the workflow it is expected that perceived ease of use and communication quality will both increase when surveying department staff. This intervention offers an alternative means of communicating with the goal of improving communication overall in the microsystem.

Methods: Through use of …

A Quality Improvement Initiative To Reinforce Education To Increase Nurses’ Knowledge And Confidence In Patient-Centered Labor Positioning, Larkyn Baum

Master's Theses and Capstones

Background: Cesarean section (CS) delivery is an important and necessary intervention, yet comes with increased risks to the patient and fetus compared to vaginal birth. CS rates have been increasing globally, and implementing interventions to promote vaginal birth, especially for nulliparous, term, singleton, vertex (NTSV) patients is of interest to patients, providers, and institutions.

Local Problem: In 2024, the CS rate within the microsystem was 32%, more than double the WHO-recommended benchmark of 10–15%. Of all CS deliveries in 2024, 31% were nulliparous, term, singleton, vertex (NTSV) patients, who are considered optimal candidates for vaginal delivery. Given the elevated rate …

A Quality Improvement Initiative: Enhancing Knowledge And Confidence In Effective Eclamptic Seizure Management Among Maternity Nurses, Emma C. Donigian

Master's Theses and Capstones

Background: Preeclampsia and eclampsia (PE/E) are leading contributors to maternal morbidity and mortality rates globally. Timely recognition and intervention are essential for improving maternal outcomes. However, evidence indicates that healthcare professionals often lack sufficient knowledge and confidence in managing these conditions, highlighting a critical need for ongoing education to ensure safe, effective care.

Local Problem: At a small maternity unit in Northern New England, nurses expressed concern about their preparedness to manage eclamptic seizures, a rare but high-risk obstetric emergency. Although preeclampsia is commonly encountered, eclampsia occurs infrequently, limiting staff exposure and hands-on experience. This combination of low frequency and …

Landscape Intactness As A Necessary Component Of Multiple-Use And Sustained-Yield Management Of Bureau Of Land Management Public Lands, Matthew S. Dietz, Alison C. Flint, R. Travis Belote

Colorado Environmental Law Journal

No abstract provided.

Greenwashed Forest Management And Wildfire Resilience, Sarah A. Matsumoto

Colorado Environmental Law Journal

No abstract provided.

State Adoption Of A Constitutional Right To A Clean And Healthy Environment: Held V. Montana As A Success For Climate Litigation, Lara Andenoro

Colorado Environmental Law Journal

No abstract provided.

Mining Association Position Statement On Indigenous Peoples: Respect For Their Rights Advanced, With Some Shortcomings, S. James Anaya

Colorado Environmental Law Journal

No abstract provided.

Interrogating Marine Plastics Pollution Regulations: The Intended Roles Of The Global Plastics Treaty, Ndubuisi Augustine Nwafor

Colorado Environmental Law Journal

No abstract provided.

Towards Multispecies Environmental Justice, Laura Street Cole

Colorado Environmental Law Journal

No abstract provided.

Holding Fossil Fuel Producers Accountable In U.S. And Other Foreign Courts: A Climate Justice Pathway For Sierra Leone, Jamil Sahid Fofanah

Colorado Environmental Law Journal

No abstract provided.

The Environmental Cost Of Intelligence: Regulating The Climate Impact Of Artificial Intelligence, Emilee Calvin

Colorado Environmental Law Journal

No abstract provided.

Still Silent: How The U.S. Regulatory Framework Fails To Address The Dangers Of Pesticides, Obie Johnson

Colorado Environmental Law Journal

No abstract provided.

Distinct Odorant Receptor Response Patterns To Aliphatic Odorants In Freely Behaving Mice, Claire A. De March, Patrick Breheny, William B. Titlow, Hiroaki Matsunami, Timothy S. Mcclintock

Physiology Faculty Publications

In mammals, odors are encoded by a combinatorial code determined by the pattern of responses across hundreds of odorant receptors expressed monogenically and monoallelically in olfactory sensory neurons. The compositions of these receptor response patterns are largely unknown and overlap between them has yet to be explored. Activity-dependent reporter gene expression in freely behaving S100a5-tauGFP mice allowed capture of activated olfactory sensory neurons and identified 168 receptors responsive to moderate concentrations of 1 or more of 12 aliphatic (5 to 8 carbons) ketones, alcohols, and carboxylic acids. These 12 response patterns are remarkably different, with only 19% of the receptors …

Feeding- And Light-Cycle Synergistically Regulate Mouse Blood Pressure Daily Rhythm Via Bmal1-Dependent And Independent Mechanisms, Tianfei Hou, Wen Su, Aaron Chacon, An-Hsuan Lin, Zhenheng Guo, Ming C. Gong

Physiology Faculty Publications

Cardiovascular health requires the orchestration of the daily rhythm of blood pressure (BP), which responds to changes in light exposure and dietary patterns. Whether rhythmic light and feeding can modulate daily BP rhythm directly or via modulating intrinsic core clock gene Bmal1 is unknown. Using inducible global Bmal1 knockout mice (iBmal1KO), we explored the impact of rhythmic light, rhythmic feeding, or their combination on various physiological parameters. Daily rhythms of BP, heart rate, and locomotor activity were monitored via radiotelemetry, while food intake patterns were tracked using the BioDAQ system. Respiratory exchange ratio (RER) and energy expenditure (EE) were assessed …

The Alcohol Exposome, Nousha H. Sabet, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries. This manuscript presents selected key variables that represent the Alcohol Exposome. The primary variables that make up the Alcohol Exposome can include comorbidities such as cigarettes, poor diet, occupational hazards, environmental hazards, infectious agents, and aging. In addition to representing multiple factors, the Alcohol Exposome examines the various types …

Differential Plasma Carotenoid Profiles In Hypertensive Disorders Of Pregnancy, Colman Freel, Jonah Scheffler, Rebecca Drakowski, Elizabeth Lyden, Matthew Van Ormer, Melissa K. Thoene, Paras K. Mishra, Corrine K. Hanson, Ann Anderson-Berry

Journal Articles: Pediatrics

Background: Hypertensive disorders of pregnancy (HDP) affect one in six pregnancies globally. The etiology of HDP remains unclear but is known to involve oxidative stress. While the body produces endogenous antioxidants, antioxidative nutrients, like carotenoids, remain critical in modulating oxidative stress. The statuses of several carotenoids have been linked to hypertension in both pregnant and non-pregnant populations. However, their associations with the spectrum of HDP, including gestational hypertension (GH), chronic hypertension (CH), and preeclampsia (PE), remains unclear. Our objective was to quantify and compare carotenoid intake and plasma levels among HDP. Methods: We conducted a prospective cohort study …

Prosecutorial Reform And The Myth Of Individualized Enforcement, Justin Murray

Articles & Chapters

The American prosecutor’s legitimacy faces unprecedented challenges. A new wave of reformist prosecutors has risen to power promising to transform the criminal justice system from within, sparking fierce backlash from defenders of the prosecutorial status quo. Central to this conflict is a debate over the nature of prosecutorial discretion, influenced by a set of claims and assumptions that this Article terms the myth of individualized enforcement. This myth posits that prosecutors base discretionary decisions on case-specific facts and equitable circumstances rather than generalizable criteria or categorical nonenforcement practices, such as the policies some reformist prosecutors have adopted that disfavor prosecuting …

Like Holding Up A Mirror: How I Learned To Teach Restorative Justice, Susan Abraham

Articles & Chapters

No abstract provided.

Housing Justice Pipeline: Harnessing Housing Clinics To Transform The Right To Counsel Movement, Erica Braudy, Thomas Honan, Tuhfa Begum

Articles & Chapters

No abstract provided.

Defining The Discipline: Six Pillars Of Academic Success Programming In Law Schools, Kris Franklin, Catherine Martin Christopher

Articles & Chapters

No abstract provided.

Methylome–Proteome Integration After Late-Life Voluntary Exercise Training Reveals Regulation And Target Information For Improved Skeletal Muscle Health, Toby L Chambers, Andrea Dimet-Wiley, Alexander R Keeble, Amin Haghani, Wen-Juo Lo, Gyumin Kang, Robert Brooke, Steve Horvath, Christopher S Fry, Stanley J Watowich, Yuan Wen, Kevin A Murach

Physiology Faculty Publications

Abstract: Exercise is a potent stimulus for combatting skeletal muscle ageing. To study the effects of exercise on muscle in a preclinical setting, we developed a combined endurance–resistance training stimulus for mice called progressive weighted wheel running (PoWeR). PoWeR improves molecular, biochemical, cellular and functional characteristics of skeletal muscle and promotes aspects of partial epigenetic reprogramming when performed late in life (22–24 months of age). In this investigation, we leveraged pan-mammalian DNA methylome arrays and tandem mass-spectrometry proteomics in skeletal muscle to provide detailed information on late-life PoWeR adaptations in female mice relative to age-matched sedentary controls (n = 7–10 …

Nonresolving Neuroinflammation Regulates Axon Regeneration In Chronic Spinal Cord Injury, Andrew N. Stewart, Christopher C. Bosse-Joseph, Reena Kumari, William M. Bailey, Kennedy A. Park, Victoria K. Slone, John C. Gensel

Physiology Faculty Publications

Chronic spinal cord injury (SCI) lesions retain increased densities of microglia and macrophages. In acute SCI, macrophages induce growth cone collapse and facilitate axon retraction away from lesion boundaries. Little is known about the role of sustained inflammation in chronic SCI or whether chronic inflammation affects regeneration. We used the colony-stimulating factor-1 receptor inhibitor, PLX-5622, to deplete microglia and macrophages months after complete crush SCI in female mice. Transcriptional analyses revealed a significant inflammatory depletion within chronic SCI lesions after PLX-5622 treatment. Both transcriptional analyses and immunohistochemistry revealed that Iba1⁺ cells repopulate to predepleted densities after treatment removal. Neuronal-enriched …

Programmable Scanning Diffuse Speckle Contrast Imaging Of Cerebral Blood Flow, Faezeh Akbari, Xuhui Liu, Fatemeh Hamedi, Mehrana Mohtasebi, Li Chen, Lei Chen, Guoqiang Yu

Physiology Faculty Publications

Significance: Cerebral blood flow (CBF) imaging is crucial for diagnosing cerebrovascular diseases. However, existing large neuroimaging techniques with high cost, low sampling rate, and poor mobility make them unsuitable for continuous and longitudinal CBF monitoring at the bedside. Aim: We aimed to develop a low-cost, portable, programmable scanning diffuse speckle contrast imaging (PS-DSCI) technology for fast, high-density, and depth-sensitive imaging of CBF in rodents. Approach: The PS-DSCI employed a programmable digital micromirror device (DMD) for remote line-shaped laser (785 nm) scanning on tissue surface and synchronized a 2D camera for capturing boundary diffuse laser speckle contrasts. New algorithms were developed …