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Articles 11761 - 11790 of 1791683
Full-Text Articles in Entire DC Network
Norm Dust Intake: Comparison Of Personal Air Sampling And Bioassays, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani
Norm Dust Intake: Comparison Of Personal Air Sampling And Bioassays, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani
Research outputs 2022 to 2026
Intake of naturally occurring radioactive materials (NORM), particularly the inhalation of thorium-bearing dust in mineral sand operations, has traditionally been assessed via personal air sampling (PAS). However, data from bioassay studies suggest that the actual intake determined via PAS may be underestimated. This review integrates thorium intake estimates derived from historical bioassay datasets, such as urine, faeces, lung counting, and thoron-in-breath tests, with historical PAS data. The findings indicated that bioassay-based predictions of intake were consistently greater, with mean bioassay-to-PAS intake ratios ranging from 2.6 to 4.2. The contributing factors to this discrepancy include biokinetic model uncertainties, potential dust sampler …
Dynamic Cable Machine For Shoulder Rehabilitation, Mostafa Elshenawy, Avery Minter, Jarrett Powell-Odden, Shepard Dow, Cole Llana, Margaret Hughes
Dynamic Cable Machine For Shoulder Rehabilitation, Mostafa Elshenawy, Avery Minter, Jarrett Powell-Odden, Shepard Dow, Cole Llana, Margaret Hughes
Interdisciplinary Design Senior Theses
Physical therapy is a branch of modern healthcare that holds crucial importance across multiple demographics, ranging from injured athletes to seniors. However, the recovery process often suffers due to a lack of quantitative progress tracking and the use of static equipment that does not adapt to the user. Furthermore, there are noticeable communication faults between the therapist and client, especially between sessions. Our dynamic rehabilitation cable machine addresses a lot of these limitations in a compact integrated system that provides adjustable motor-driven resistance, real time force measurements, and computer-vision-based exercise feedback. The main device is composed of two subsystems that …
Show Me The Money: Finance Models In Epilepsy Practice., Deepti Zutshi, Emily Klatte, Maysaa Basha, Leisha Osburn, Eric Segal, Nina Garga, Rohit R Das
Show Me The Money: Finance Models In Epilepsy Practice., Deepti Zutshi, Emily Klatte, Maysaa Basha, Leisha Osburn, Eric Segal, Nina Garga, Rohit R Das
Medical Education Articles
Healthcare models and the finances associated with such models are complex. Patients with epilepsy (PWE) receive care in a variety of settings, and each is associated with differing reimbursement, financial levers, as well as unique strengths and weaknesses. As the financial climate of healthcare system changes rapidly in the setting of an aging population, physician shortages, and increasing costs of healthcare delivery, it is important for clinicians to understand the financial aspects of caring for PWE. In this review, we examine basic concepts in healthcare economics and then review the financial aspects of care in an academic context, a private …
Gunk - Genetic Underwater Nucleic-Acid Collector, Kay Hall, Harumy Miura, Isaac Carlos Hernandez-Nguyen, Oscar Emilio Alvarado Flores
Gunk - Genetic Underwater Nucleic-Acid Collector, Kay Hall, Harumy Miura, Isaac Carlos Hernandez-Nguyen, Oscar Emilio Alvarado Flores
Interdisciplinary Design Senior Theses
Environmental DNA sampling is a powerful and minimally invasive tool for biodiversity assessment and species monitoring. However, existing environmental DNA collection systems are costly, difficult to deploy at depth at low cost and with small teams, non-standardized, and inaccessible to non-technical users. This report presents GUNK, the Georeferenced Underwater Nucleic-acid Kollector, a submersible environmental DNA sampler developed in collaboration with ConservationXLabs and the Santa Clara University Robotics Systems Laboratory. GUNK is designed to address three primary goals: reaching sampling depths unachievable by existing low-cost solutions, reducing the financial barrier associated with environmental DNA research, and ensuring the system is easily …
Navigating The Legal Waters Of Privatized Commodities And Human Rights: An Exploration Of The Tension Between Water As A Human Right And Water As Investment Property Under International Law, Ella Capen
Brooklyn Journal of International Law
This Note examines the clash between domestic law and international law within the context of Chile’s 2022 modification to the 1981 Water Code as the country transitions from treating water as a privatized commodity to water as a public good. Chile’s 1981 Water Code emerged against the backdrop of a neoliberal economic regime and privatization scheme enabled by the United States and enforced by dictator Augusto Pinochet. This Note reveals the potential difficulties in unraveling established economic and legal foundations, and the conflicts between bilateral investment treaties and local legislation that mutually govern property rights. By examining Chile’s domestic Law …
Necessary Biosafety Precautions For Patented Gmos: Ramifications Of Inconsistent Parties Between The Cartagena Protocol And Trips Agreement, Lauren Clements
Necessary Biosafety Precautions For Patented Gmos: Ramifications Of Inconsistent Parties Between The Cartagena Protocol And Trips Agreement, Lauren Clements
Brooklyn Journal of International Law
Genetically Modified Organisms (“GMOs”) compose a class of potentially patentable biotechnology that are prominent in international markets. Developed countries like the United States, function as leading producers of these patented GMOs and therefore play a significant role in their development and transnational export. Minimum protections for these forms of biotechnology are outlined in the Agreement on Trade-Related Aspects of Intellectual Property Rights (“TRIPS Agreement”), which permits the patenting of GMOs that ultimately enter the stream of international commerce. Notwithstanding the potential risks GMOs present to the environment, public health, and the economy, the TRIPS Agreement fails to address any form …
Feasibility Study Of A Behavioral Lifestyle Intervention For Hispanic/Latino Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease, Natalia I Heredia, Jessica P Hwang, Maria E Fernandez, Jiachen Lu, Cici X Bauer, Lorna H Mcneill
Feasibility Study Of A Behavioral Lifestyle Intervention For Hispanic/Latino Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease, Natalia I Heredia, Jessica P Hwang, Maria E Fernandez, Jiachen Lu, Cici X Bauer, Lorna H Mcneill
Faculty, Staff and Student Publications
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) can lead to longer-term adverse health outcomes if left unmanaged, including liver failure and liver cancer. Hispanic adults have the highest rates of MASLD of any U.S. racial/ethnic subgroup. The most effective treatment is weight loss, through healthy dietary changes and increased physical activity. This study conducted 2022-2023 aimed to assess the feasibility and acceptability (primary), as well as exploratory effectiveness outcomes, of a behavioral lifestyle intervention for Hispanic patients with MASLD.
Methods: Participants were recruited from a federally qualified health center. Self-administered questionnaires assessed demographic, psychosocial and behavioral variables. Staff measured height …
Intouch Week Of June 8, 2026, New York Medical College
Intouch Week Of June 8, 2026, New York Medical College
InTouch
- As COPD Rates Rise in Women, Clinical Trial Representation Lags
- Student Spotlight: A Look at Reimbursement Trends for Emerging Technologies
- Student Spotlight: Doneal Bromberg Receives Prestigious ASTRO Medical Student Fellowship
Perceptions Of Young Adult Menstruators’ Use Of Reusable Menstrual Products On The Relationship With Their Bodies: An Exploratory Study, Maisie Hudson
Perceptions Of Young Adult Menstruators’ Use Of Reusable Menstrual Products On The Relationship With Their Bodies: An Exploratory Study, Maisie Hudson
Sociology Between the Gaps: Forgotten and Neglected Topics
No abstract provided.
Auricular Point Acupressure Self-Management (Apa-Sm) Program For Chronic Musculoskeletal Pain Among Rural Populations: A Protocol For A Pragmatic, Randomized Controlled Trial, Jennifer Kawi, Jane Bolin, Hulin Wu, Jungkyung Min, Rupsikha Bora, Sarah Pace, Idara N Akpan, Alee Lockman, Tonychris Nnaka
Auricular Point Acupressure Self-Management (Apa-Sm) Program For Chronic Musculoskeletal Pain Among Rural Populations: A Protocol For A Pragmatic, Randomized Controlled Trial, Jennifer Kawi, Jane Bolin, Hulin Wu, Jungkyung Min, Rupsikha Bora, Sarah Pace, Idara N Akpan, Alee Lockman, Tonychris Nnaka
Faculty, Staff and Student Publications
Introduction: Chronic musculoskeletal pain (CMP) is a leading cause of incurred personal healthcare costs and disability in the USA. It disproportionately affects rural populations, who are more likely to be uninsured, lack access to a regular healthcare provider and experience a higher prevalence of CMP. As a result of reduced access to non-pharmacological care, there is greater reliance on opioids. The Auricular Point Acupressure - Self-Management (APA-SM) program is a simple, needleless, evidence-based therapy that empowers individuals to self-manage their pain. Preliminary studies, including a recent UG3 pilot testing, demonstrated feasibility, safety and significant improvements in pain and function. Guided …
Faculty Perceptions Of Lgbtq+ Students In Higher Education, Serena Gramling, Laura E. Barrow, Stacy Mikel, Mark J. Sciuchetti Dr., Falynn Turley
Faculty Perceptions Of Lgbtq+ Students In Higher Education, Serena Gramling, Laura E. Barrow, Stacy Mikel, Mark J. Sciuchetti Dr., Falynn Turley
Higher Learning Research Communications
Objective: Limited faculty understanding of LGBTQ+ student experiences may contribute to exclusionary campus climates and discriminatory practices. This study examined faculty perceptions to identify ways to improve support for LGBTQ+ students and promote inclusive environments.
Method: A descriptive quantitative design was used to examine faculty perceptions of LGBTQ+ students and differences across geographic regions. 142 participants completed the 20-item instrument.
Results: Although regional differences in acceptance were observed, geographic location did not significantly predict faculty attitudes. Faculty acceptance played a key moderating role in the relationship between awareness and engagement in inclusive practices. Findings indicated that faculty attitudes alone are …
A Comprehensive Review Of Optimization Techniques For Healthcare Using Cancer Datasets, Dina Tbaishat, Mohammad Tubishat, Sharif Naser Makhadmeh, Mohammed Azmi Al-Betar
A Comprehensive Review Of Optimization Techniques For Healthcare Using Cancer Datasets, Dina Tbaishat, Mohammad Tubishat, Sharif Naser Makhadmeh, Mohammed Azmi Al-Betar
All Works
This study presents a systematic review of metaheuristic optimization techniques applied to healthcare problems using cancer datasets. A structured search of recently published peer-reviewed literature was carried out, focusing on five major application areas: feature selection, classification, image segmentation, hyperparameter tuning, and early detection. For each eligible study, the optimization strategy, dataset characteristics, data modality, learning model, validation protocol, and reported outcomes are provided. The reviewed works were organized into a taxonomy of original, modified, and hybridized algorithms, and a descriptive analysis was performed to assess algorithm prevalence and dataset utilization. The findings highlight that feature selection remains the most …
Assessment Of The Status Of Open Access Publications In Central Universities Of India: A Review Of Literature, Gulam Jilani, Swapna Banerjee
Assessment Of The Status Of Open Access Publications In Central Universities Of India: A Review Of Literature, Gulam Jilani, Swapna Banerjee
Library Philosophy and Practice (e-journal)
Unrestricted access to research outputs and increased exposure and distribution of academic information are two benefits of Open Access (OA) publication, which has emerged as a revolutionary method to scholarly communication. With an emphasis on its economic models, international and Indian publishing trends, institutional activities, regulations, and researcher attitudes, this study explores the literature on open access publishing. The paper examines many OA models, such as gold, green, hybrid, bronze, and diamond access, emphasizing their benefits, drawbacks, and implications for the fair distribution of information. The expansion of open access publication in India and throughout the world is also covered, …
Home Is Not Always Where The Heart Is: Examining The Inadequacy Of Legal Measures In The Deportation Of American Intercountry Adoptees, Katie X. Kaessinger, Esq.
Home Is Not Always Where The Heart Is: Examining The Inadequacy Of Legal Measures In The Deportation Of American Intercountry Adoptees, Katie X. Kaessinger, Esq.
San Diego International Law Journal
Despite entering the United States legally as children through intercountry adoption, thousands of American adoptees face deportation as adults because their parents failed to finalize their citizenship. Many of these adoptees have no meaningful linguistic, cultural, or familiar ties to their birth countries, and most have lived in the United States practically their entire lives. This Article explores the legal implications regarding the deportation of intercountry adoptees. More specifically, this Article argues that the deportation of intercountry adoptees reflects a grave systemic failure that violates international human rights law, rather than a mere shortcoming of domestic immigration policy.
Consulting various …
Film, Television, And Artificial Intelligence: Ensuring The Role Of Screenwriters In Anticipation Of Generative Artificial Intelligence’S Increasing Capabilities, Rachel Johnson
San Diego International Law Journal
Artificial Intelligence (AI) currently is one of most critical topics discussed across industries. AI technology, such as Generative Artificial Intelligence (GAI), looms over people employed in creative fields who view it as a threat to their livelihoods. Legislative and judicial law must grapple with the complex legal issues GAI poses. In the entertainment realm, employees in professions such as Hollywood’s film industry have found ways to secure their present and near future against AI-encroachment.
In 2023, the Writers Guild of America (WGA), a labor union covering the screenwriters of television and film, coordinated the second longest labor strike in Hollywood’s …
Invisible Nations: Self-Determination As A Legal Shield For The World’S Last Isolated Peoples, Paige Schacher
Invisible Nations: Self-Determination As A Legal Shield For The World’S Last Isolated Peoples, Paige Schacher
San Diego International Law Journal
This Comment examines the legal and ethical considerations of self-determination as applied to the world’s last uncontacted tribes—indigenous communities that live isolated from mainstream society. While the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) established a foundational framework for uncontacted tribes’ right to self-determination, its implementation in practice faces jurisdictional, ethical, and legal issues. By examining international and domestic legal instruments, case studies from India and Brazil, and the evolving role of artificial intelligence in indigenous land monitoring, this Comment argues that domestic and international bodies must collaborate to enforce more tailored protections to guard the autonomy …
Development And Preliminary Validation Of Orca-Pd, An Online Rapid Cognitive Assessment For Parkinson Disease: Mixed Methods Study, Avigail Lithwick Algon, Sarah Brisman, Chi-Ying R Lin, William Saban
Development And Preliminary Validation Of Orca-Pd, An Online Rapid Cognitive Assessment For Parkinson Disease: Mixed Methods Study, Avigail Lithwick Algon, Sarah Brisman, Chi-Ying R Lin, William Saban
Faculty, Staff and Students Publications
Background: Traditional in-person neuropsychological tests for Parkinson disease (PD) lack accessibility, scalability, and PD specificity. Mobility impairments hinder access to in-person assessments, and long waiting times for expert evaluation limit scalability. Common tools for cognitive screening, such as the Montreal Cognitive Assessment, are generic and not specific to PD.
Objective: The goal of this study was to address these challenges by leveraging the internet. This study aimed to develop a sensitive tool to detect cognitive impairments in early- to mid-stage PD in an accessible and scalable manner.
Methods: We developed the Online Rapid Cognitive Assessment for Parkinson's Disease (ORCA-PD), a …
Land Forward: Planning For Legal Reforms To Facilitate Land Back And Community-Driven Relocation In Response To Climate Change, E. Barrett Ristroph
Land Forward: Planning For Legal Reforms To Facilitate Land Back And Community-Driven Relocation In Response To Climate Change, E. Barrett Ristroph
San Diego Journal of Climate & Energy Law
Indigenous and other place-based communities face the loss of their homes due to climate change. The practices that have led to the current climate crisis have also contributed to the historical dispossession and marginalization of these communities. United States laws and programs already provide for land transfers to federally recognized tribes, home buyouts for households in hazard-prone areas, and community development. But these laws and programs are piecemeal, reactive, and often inaccessible to the communities most in need. They do not provide a streamlined method for tribes to regain lands needed for rematriation and adaptation. Nor do they allow place-based …
Back To Intent: Revamping California’S Flagship Environmental Legislation And Tackling The Rise Of The “Super-Commuter”, Jordan Q. Davis
Back To Intent: Revamping California’S Flagship Environmental Legislation And Tackling The Rise Of The “Super-Commuter”, Jordan Q. Davis
San Diego Journal of Climate & Energy Law
The passage of the California Environmental Quality Act (CEQA) in 1970 has long been considered a watershed moment in the evolution of government participation in environmental issues. In the years since, CEQA has played a pivotal role in protecting Californians’ access to the beautiful nature offered by the Golden State. However, the very regulation that has been repeatedly relied upon to breathe clean air and drink clean water may very well be an instrument upon which Californians could return to smog-ridden skies. In this regard, CEQA’s biggest vulnerability may come from a most unexpected place: its strength.
The tools by …
Soaring To New Heights Through The Lens Of The Scarlet Macaw–A Post-Loper Bright Interpretation Of The Endangered Species Act’S “Significant Portion Of Its Range” For A Climate-Driven “Foreseeable Future”, Kathryn Wood
San Diego Journal of Climate & Energy Law
This Comment will argue for particular interpretations of “significant portion of its range” and “foreseeable future” under the ESA to prioritize species preservation in the face of climate change.
The analysis begins by describing key aspects of the ESA, including its historical background, its conceptual definitions, its prescribed method for determining endangered species and threatened species, its listing process, and critical habitat requirements. This Comment then discusses climate change as a source of threat and endangerment “within the foreseeable future,” and whether acts worsening climate change can constitute an unlawful taking. Next, this Comment considers how the Supreme Court’s decision …
Unlocking Green Innovation: Navigating Trade Secret Law In The Quest For Sustainable Solutions, Jacob Wright
Unlocking Green Innovation: Navigating Trade Secret Law In The Quest For Sustainable Solutions, Jacob Wright
San Diego Journal of Climate & Energy Law
This Comment explores the tension between trade secret protections and the global demand for climate-related technologies, arguing that a more balanced approach is necessary to align intellectual property law with the public interest. By examining the limits of existing legal frameworks, such as the DTSA, this analysis will highlight how these laws prioritize proprietary interests over environmental needs. It will also propose regulatory strategies that could help bridge this gap, such as expanding compulsory licensing frameworks, implementing public-private partnerships, and introducing public interest exceptions specifically tailored to clean energy technologies. Ultimately, this comment aims to contribute to the ongoing conversation …
Structured Telehealth Community Health Worker-Clinician Feedback And Diabetes Outcomes: A Randomized Clinical Trial, Elizabeth M Vaughan, Xiaoying Yu, Amber B Amspoker, Aanand D Naik, Ashok Balasubramanyam, Craig A Johnston, Christi M Ballantyne, Salim S Virani, H Shelton Brown, Kristina Mena, Laura R Porterfield
Structured Telehealth Community Health Worker-Clinician Feedback And Diabetes Outcomes: A Randomized Clinical Trial, Elizabeth M Vaughan, Xiaoying Yu, Amber B Amspoker, Aanand D Naik, Ashok Balasubramanyam, Craig A Johnston, Christi M Ballantyne, Salim S Virani, H Shelton Brown, Kristina Mena, Laura R Porterfield
Faculty, Staff and Students Publications
Importance: Community health workers (CHWs) improve chronic disease management in underserved populations, but scalable integration strategies are limited.
Objective: To evaluate whether a multidimensional intervention incorporating telementored CHWs and a structured participant-CHW-clinician feedback loop can improve diabetes outcomes.
Design, setting, and participants: This 12-month randomized clinical trial was conducted at 3 institutionally and geographically diverse community clinics in Texas between September 1, 2023, and April 30, 2025, and included low-income, uninsured White Hispanic adults with type 2 diabetes identified through clinic databases. Data were analyzed between May 1 and July 31, 2025.
Intervention: Individuals were randomized 1:1 to the intervention …
Notch1 Acts As A Tumor Suppressor That Induces Early Differentiation In Head And Neck Cancer, Chenfei Huang, Shhyam Moorthy, Qiuli Li, Kazi M Ahmed, Kalil Saab, Defeng Deng, Jiping Wang, Xiayu Rao, Jiexin Zhang, Yuanxin Xi, Jing Wang, Zhiyi Liu, Noriaki Tanaka, David A Wheeler, Eve Shinbrot, Rami Saade, Curtis R Pickering, Tong-Xin Xie, Adel K El-Naggar, Abdullah A Osman, Kunal Rai, Patrick A Zweidler-Mckay, John V Heymach, Lauren A Byers, Faye M Johnson, Vlad C Sandulache, Jeffrey N Myers, Pedram Yadollahi, Mitchell J Frederick
Notch1 Acts As A Tumor Suppressor That Induces Early Differentiation In Head And Neck Cancer, Chenfei Huang, Shhyam Moorthy, Qiuli Li, Kazi M Ahmed, Kalil Saab, Defeng Deng, Jiping Wang, Xiayu Rao, Jiexin Zhang, Yuanxin Xi, Jing Wang, Zhiyi Liu, Noriaki Tanaka, David A Wheeler, Eve Shinbrot, Rami Saade, Curtis R Pickering, Tong-Xin Xie, Adel K El-Naggar, Abdullah A Osman, Kunal Rai, Patrick A Zweidler-Mckay, John V Heymach, Lauren A Byers, Faye M Johnson, Vlad C Sandulache, Jeffrey N Myers, Pedram Yadollahi, Mitchell J Frederick
Faculty, Staff and Students Publications
Inactivating NOTCH1 mutations in head and neck squamous cell carcinoma (HNSCC) were described over a decade ago, suggesting a tumor suppressor function - unlike its oncogenic role in other tumors. Today, much debate persists regarding a putative oncogenic role in HNSCC as well, with reports that NOTCH1 signaling drives tumor growth and a cancer stem cell (CSC) phenotype. In this work, comprehensive experiments unequivocally demonstrate that NOTCH1 is a tumor suppressor in HNSCC regardless of mutation or activation status and that it reduces CSC frequency. We developed a signature of NOTCH1 activation showing the pathway is associated with very early …
Redefining The Norms: An Interdisciplinary Perspective On Language Testing In Multilinguals With Acquired And Progressive Neurogenic Disorders, Alessa Hausmann, Adolfo M. García, Ana Sofia Costa, Arpita Bose, Boon Lead Tee, Claudia Rivera-Fernandez, Eduardo Europa, Gitit Kavé, Jee Eun Sung, Maira Okada De Oliveira, Mandy Wigdorowitz, Maria Garraffa, Maria Teresa Carthery-Goulart, Michael J. Kleiman, Naama Friedmann, Samir Diouny, Sanne Franzen, Sofia Toniolo, Stephanie Grasso, Thomas H. Bak
Redefining The Norms: An Interdisciplinary Perspective On Language Testing In Multilinguals With Acquired And Progressive Neurogenic Disorders, Alessa Hausmann, Adolfo M. García, Ana Sofia Costa, Arpita Bose, Boon Lead Tee, Claudia Rivera-Fernandez, Eduardo Europa, Gitit Kavé, Jee Eun Sung, Maira Okada De Oliveira, Mandy Wigdorowitz, Maria Garraffa, Maria Teresa Carthery-Goulart, Michael J. Kleiman, Naama Friedmann, Samir Diouny, Sanne Franzen, Sofia Toniolo, Stephanie Grasso, Thomas H. Bak
Faculty Research, Scholarly, and Creative Activity
Accurate language assessment is essential in clinical and research contexts. However, most assessment tools and questionnaires have been developed within monolingual frameworks, overlooking the particularities of the vast multilingual population and, thus, often leading to misdiagnosis and inequitable care. Here, we examine the limitations of monolingual-centric approaches to language testing in multilinguals with acquired and progressive neurogenic disorders and explore the implications of multilingualism across linguistic, cognitive, neural, clinical, and sociocultural domains. We also address the need for technological innovation and theoretical refinement to better accommodate linguistic diversity in healthcare. Ultimately, we advocate for a nuanced, equitable, and culturally sensitive …
Aid And Assist Cases In Multnomah County: An Exploration Of Ors 161.370, Savannah Jurasek
Aid And Assist Cases In Multnomah County: An Exploration Of Ors 161.370, Savannah Jurasek
Dissertations and Theses
Individuals with severe mental illness (SMI) are highly overrepresented in jails. In Oregon, these individuals can be eligible for what is referred to as the aid and assist process (ORS 161.370) which is designed to facilitate restorative care in efforts to ensure that vulnerable individuals can rationally participate in their criminal proceedings. However, continuous escalation in aid and assist orders (109.3% between 2011-2025) has led to strain on the Oregon State Hospital, the primary care facility for this population. As a consequence, defendants with SMI are spending unnecessary time in custody, despite hospitalization admission guidelines governed by previously decided case …
Proof-Of-Concept Study For The Detection Of Somatic Structural Variant Driver Alterations Using Hifi Long-Read Sequencing In A Pediatric Leukemia Cohort., Lisa A. Lansdon, Byunggil Yoo, Ayse Keskus, Irina Pushel, Chengpeng Bi, Tanveer Ahmad, Asher Bryant, Adam Walter, Margaret Gibson, Mary Rindler, Weijie Li, Sahibu Sultan M Habeebu, Linda D. Cooley, John Herriges, Elena Repnikova, Lei Zhang, Keith August, Terrie Flatt, Alan S. Gamis, Erin M. Guest, J Allyson Hays, Maxine Hetherington, Karen Lewing, Tomi Pastinen, Mikhail Kolmogorov, Midhat S. Farooqi
Proof-Of-Concept Study For The Detection Of Somatic Structural Variant Driver Alterations Using Hifi Long-Read Sequencing In A Pediatric Leukemia Cohort., Lisa A. Lansdon, Byunggil Yoo, Ayse Keskus, Irina Pushel, Chengpeng Bi, Tanveer Ahmad, Asher Bryant, Adam Walter, Margaret Gibson, Mary Rindler, Weijie Li, Sahibu Sultan M Habeebu, Linda D. Cooley, John Herriges, Elena Repnikova, Lei Zhang, Keith August, Terrie Flatt, Alan S. Gamis, Erin M. Guest, J Allyson Hays, Maxine Hetherington, Karen Lewing, Tomi Pastinen, Mikhail Kolmogorov, Midhat S. Farooqi
Manuscripts, Articles, Book Chapters and Other Papers
Gene fusions are common primary drivers of pediatric leukemias and are the result of underlying structural variants (SVs). Current clinical workflows to detect such alterations rely on a multimodal approach, which often increases analysis time and overall cost of testing. In this study, we used long-read sequencing (lrSeq) as a proof-of-concept to determine whether clinically relevant (cr) SVs could be detected within a small (n = 17) pediatric leukemia cohort. We show that this methodology successfully determined all known crSVs (n = 5/5) detected through routine clinical testing. This approach also identified crSVs that resulted in the classification of a …
Recent Antibiotic Exposure And Response To Treatment Of Juvenile Idiopathic Arthritis: A Retrospective Cohort Study, Daniel Horton, Charu Verma, Sanika Rege, Stephen Crystal, Tobias Gerhard, Alicia Iizuka, Matthew Iozzio, Dawn Koffman, Lauren Parlett, Julianne Varga, Carlos Rose, Brian Strom
Recent Antibiotic Exposure And Response To Treatment Of Juvenile Idiopathic Arthritis: A Retrospective Cohort Study, Daniel Horton, Charu Verma, Sanika Rege, Stephen Crystal, Tobias Gerhard, Alicia Iizuka, Matthew Iozzio, Dawn Koffman, Lauren Parlett, Julianne Varga, Carlos Rose, Brian Strom
Department of Medicine Faculty Papers
BACKGROUND: Juvenile idiopathic arthritis (JIA) has been tied to microbiome disruption and antibiotic exposure. Gut microbiota may affect how adults with rheumatoid arthritis respond to methotrexate. We tested if exposure to antibiotics was associated with response to methotrexate for JIA.
METHODS: We conducted a retrospective cohort study using national US public and private insurance claims data (2001-2023). We included children ages 1-17 continuously enrolled for ≥ 10 months and diagnosed with JIA who initiated methotrexate monotherapy or, for comparison, tumor necrosis factor inhibitor (TNFi) monotherapy without prior disease-modifying antirheumatic drug (DMARD) exposure. Antibiotic exposure during the 10-month baseline period was …
Crowdsourced Biometric Synchronization For Video Intensity Mapping And Benchmarking, Alan She
Crowdsourced Biometric Synchronization For Video Intensity Mapping And Benchmarking, Alan She
Defensive Publications Series
This paper describes a biometric-to-video synchronization engine that pairs wearable physiological sensors with a distributed video platform for crowdsourced intensity mapping and normalized effort-based benchmarking. Fitness video content on open platforms typically relies on subjective difficulty labels assigned by creators, which fail to account for the physiological diversity of viewers. The synchronization engine establishes a temporal sync anchor between a wearable device's biometric data stream and the video playback timeline, employing clock-drift compensation to align UTC-stamped biometric packets with the relative playback head and a latency correction algorithm to account for physiological response delay. As anonymized, normalized heart rate data …
System And Method For User-Owned Longitudinal Memory And Interpretation System With A Provenance-Tagged Interpretive Ledger, Engine-Interchangeable Inference, Federated Validation, And Generational Maintenance, Joseph Jm Walker
Defensive Publications Series
Contemporary personal-AI systems preserve continuity in the weakest possible way: the provider owns the model, the memory, and the interface, and the user retains accumulated context only so long as the service remains available and willing to keep it. When a model changes, a platform resets memory, or a provider alters policy, the user's interpretive history can vanish. This disclosure presents the Continuity Node Framework, a user-owned, local-first, longitudinal memory-and-interpretation architecture in which the durable asset is not the AI model but the preserved, provenance-tagged map of a person's reasoning, values, patterns, and tested interpretations over time, and in which …
Predictive Hardware State Mitigation Using Telemetry And Feedback, Mohsen Heidarinejad, Farid Kenarangi, Arpit Mittal, Amin Khajeh
Predictive Hardware State Mitigation Using Telemetry And Feedback, Mohsen Heidarinejad, Farid Kenarangi, Arpit Mittal, Amin Khajeh
Defensive Publications Series
Varying computational tasks introduce thermal and power dependencies within modern computing devices. Static threshold policies might not fully capture cumulative operational stress, potentially causing over-throttling or delayed hardware responses. A closed-loop machine learning framework is disclosed that dynamically evaluates multidimensional telemetry data to compute a predictive risk score. A feature selector extracts direct measurements, system activity indicators, temporal features, and health indicators. Based on the calculated risk score, an arbitrator dynamically applies mitigation actions (e.g., scaling component voltage and frequency states). A model corrector operates during hardware idle periods to iteratively refine predictive modeling using observed performance metrics. The disclosed …