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Effect Of Autologous Nanofat Injection In Post-Traumatic Atrophic Scars: A Prospective Randomized Interventional Clinical Study, Ghada M. Hammad, Manar Sallam, Sherif R. Ismail, Ahmed M. Zenia, Shereen Ezzalregal Alashry Jan 2025

Effect Of Autologous Nanofat Injection In Post-Traumatic Atrophic Scars: A Prospective Randomized Interventional Clinical Study, Ghada M. Hammad, Manar Sallam, Sherif R. Ismail, Ahmed M. Zenia, Shereen Ezzalregal Alashry

Mansoura Medical Journal

Background Post-traumatic scars continue to be a challenging issue for both patients and surgeons. Nanofat, a novel tool in regenerative medicine, relies primarily on adipose-derived stem cells (ADSCs). These cells aid in wound healing by promoting angiogenesis and secreting growth factors that help decrease inflammation and fibrous tissue formation. Aim of the study To assess the aesthetic results of autologous nanofat injection in post-traumatic atrophic scars. Patients and methods 30 cases with post-traumatic atrophic scars received a single session of nanofat injection. Evaluation was done 3 and 6 months after the session using the Vancouver scar scale. Results Our study …


Urinary Transferrin As A Marker For Diagnosis And Progression Of Diabetic Nephropathy: Short-Term Follow Up, Ghada El-Said Ahmed Ibrahim, Ibrahim Mohammed Adel Ibrahim Bakr, Amany Ragab Youssef Ahmed, Rasha Mahmoud Abdel Fattah Jan 2025

Urinary Transferrin As A Marker For Diagnosis And Progression Of Diabetic Nephropathy: Short-Term Follow Up, Ghada El-Said Ahmed Ibrahim, Ibrahim Mohammed Adel Ibrahim Bakr, Amany Ragab Youssef Ahmed, Rasha Mahmoud Abdel Fattah

Mansoura Medical Journal

Background: One of the most serious and devastating effects of diabetes mellitus is diabetic nephropathy, which in many cases progresses to end-stage kidney disease (ESKD). Microalbuminuria is currently the gold standard biomarker for DN diagnosis. Microalbuminuria has a poor predictive value, though. Patients occasionally experienced progressive renal failure without microalbuminuria. A plasma protein called transferrin has a different ionic charge from albumin but is otherwise similar in weight. Aim: Our objectives were to evaluate urinary transferrin as a more accurate and earlier marker for the diagnosis of diabetic kidney disease and to investigate its relationship to the excretion of urinary …


A Comparative Study On The Therapeutic Efficacy Of Manual Versus Automated Prepared Platelet Poor Plasma Gel For Atrophic Acne Scar Treatment: A Prospective Randomized Interventional Study, Yassmin Gamal Salem Dorgham, Fatma Faisal El Dakrory, Marwa Zohdy Ali Moubarak Jan 2025

A Comparative Study On The Therapeutic Efficacy Of Manual Versus Automated Prepared Platelet Poor Plasma Gel For Atrophic Acne Scar Treatment: A Prospective Randomized Interventional Study, Yassmin Gamal Salem Dorgham, Fatma Faisal El Dakrory, Marwa Zohdy Ali Moubarak

Mansoura Medical Journal

Introduction Atrophic acne scars are challenging to treat, prompting interest in regenerative therapies like platelet-poor plasma (PPP) gel. The purpose of this study is to compare the therapeutic efficacy and safety of manually versus automatically prepared PPP gel for treating atrophic acne scars. Material and Methods In a prospective, randomized, single-blind study, 40 patients with atrophic acne scars were divided into two equal groups. Group 1 received manually prepared PPP gel, and Group 2 received automated PPP gel, both following subcision. Treatment outcomes were evaluated using dermoscopic imaging, Goodman and Baron qualitative grading system, and patient satisfaction scores over a …


Inconsistency In Physician Orders For Life-Sustaining Treatment (Polst) Documentation, An Opportunity For Improvement, William Carmichael, Zachary Matuzsan Do, Timothy J. Friel Md, Katie Best Rn, David B. Burmeister Do, Facep, Cpe, Justin Stauffer Pa-C, Katelyn Mclain, Jessica K. Eygnor Do, Marna R. Greenberg Do, Mph, Facep, Jennifer Allen Md Jan 2025

Inconsistency In Physician Orders For Life-Sustaining Treatment (Polst) Documentation, An Opportunity For Improvement, William Carmichael, Zachary Matuzsan Do, Timothy J. Friel Md, Katie Best Rn, David B. Burmeister Do, Facep, Cpe, Justin Stauffer Pa-C, Katelyn Mclain, Jessica K. Eygnor Do, Marna R. Greenberg Do, Mph, Facep, Jennifer Allen Md

Department of Emergency Medicine

No abstract provided.


Gaps In Advance Care Planning Among High End-Of-Life Index Ed Patients Destined For Psychiatric Facilities, Jacob Adams, Jessica K. Eygnor, Courtney Moore Md, David B. Burmeister Do, Facep, Cpe, David M. Richardson Md, Jennifer Allen Md, Justin Stauffer Pa-C, Katie Best Rn, Katelyn Mclain, Matthew Mccambridge Md, Timothy J. Friel Md, Zhe Chen, Chadd K. Kraus Do, Shadi Jarjous Md, Marna R. Greenberg Do, Mph, Facep Jan 2025

Gaps In Advance Care Planning Among High End-Of-Life Index Ed Patients Destined For Psychiatric Facilities, Jacob Adams, Jessica K. Eygnor, Courtney Moore Md, David B. Burmeister Do, Facep, Cpe, David M. Richardson Md, Jennifer Allen Md, Justin Stauffer Pa-C, Katie Best Rn, Katelyn Mclain, Matthew Mccambridge Md, Timothy J. Friel Md, Zhe Chen, Chadd K. Kraus Do, Shadi Jarjous Md, Marna R. Greenberg Do, Mph, Facep

Department of Emergency Medicine

No abstract provided.


Paving Professional Development Tracks: Create A Road From Scholarship To Program Requirements, Nathalie Torres Do, Shawn M. Quinn Do, Gavin C. Barr Jr. Md, Alexandra Amaducci Do, Mary Nemeth, Dawn M. Yenser, Bryan G. Kane Md Jan 2025

Paving Professional Development Tracks: Create A Road From Scholarship To Program Requirements, Nathalie Torres Do, Shawn M. Quinn Do, Gavin C. Barr Jr. Md, Alexandra Amaducci Do, Mary Nemeth, Dawn M. Yenser, Bryan G. Kane Md

Department of Emergency Medicine

No abstract provided.


The Ecoformative And Transformative Issues Of Nature In The Schoolyard: An Exploration Of The Relationship Between Everyday Experiences Of Nature And Well-Being At School, Alix Cosquer, Olivier Gimenez, Arnaud Gregoire, Vincent Girard, Thierry Noell, Tatiana Wasella Jan 2025

The Ecoformative And Transformative Issues Of Nature In The Schoolyard: An Exploration Of The Relationship Between Everyday Experiences Of Nature And Well-Being At School, Alix Cosquer, Olivier Gimenez, Arnaud Gregoire, Vincent Girard, Thierry Noell, Tatiana Wasella

Cities and the Environment (CATE)

In urban areas, the implementation of schoolyard facilities (especially through the greening of these spaces) aims to promote children's contact with nature to improve well-being and increase their awareness of environmental preservation. In this study, we use the prospect of schoolyard landscaping in two French schools to conduct research on pupils’ relationship with nature and well-being at school. We explore cognitive and social mechanisms that affect children's perceptions and behaviour in their relationships with nature on a daily basis and in the school context, with a view toward implementing schoolyard designs.

The research aims are (i) to gain a better …


Birth On Mother Earth: Mitigating The Maternal Health Crisis, Jill C. Engle Jan 2025

Birth On Mother Earth: Mitigating The Maternal Health Crisis, Jill C. Engle

Faculty Scholarship

Maternal health outcomes in the U.S. are remarkably poor, especially when compared to those in other industrialized countries. For example, our maternal death rate is more than twice that of Canada’s. Women of color in the U.S. suffer maternal morbidity and mortality at rates considerably higher than white women. Indigenous women experience the worst maternal health outcomes of all. Yet, most maternal deaths and injuries are preventable. Furthermore, rates of maternal harm, including death, are lower when midwives and similar birthing attendants are involved. This Article is the first to fully explore the unique skillset of traditional birth attendants (TBAs). …


Effects Of Interventions For The Prevention And Management Of Maternal Anemia In The Advent Of The Covid-19 Pandemic: Systematic Review And Meta-Analysis, John Kyalo Muthuka, Diana Kageni Mbari-Fondo, Francis Muchiri Wambura, Kelly Oluoch, Japheth Mativo Nzioki, Everlyn Musanga Nyamar, Rosemary Nabaweesi Jan 2025

Effects Of Interventions For The Prevention And Management Of Maternal Anemia In The Advent Of The Covid-19 Pandemic: Systematic Review And Meta-Analysis, John Kyalo Muthuka, Diana Kageni Mbari-Fondo, Francis Muchiri Wambura, Kelly Oluoch, Japheth Mativo Nzioki, Everlyn Musanga Nyamar, Rosemary Nabaweesi

Faculty Publications

Background:The COVID-19 pandemic presented many unknowns for pregnant women, with anemia potentially worsening pregnancy outcomes due to multiple factors.

Objective:This review aimed to determine the pooled effect of maternal anemia interventions and associated factors during the pandemic.

Methods:Eligible studies were observational and included reproductive-age women receiving anemia-related interventions during the COVID-19 pandemic. Exclusion criteria comprised non-English publications, reviews, editorials, case reports, studies with insufficient data, sample sizes below 50, and those lacking DOIs. A systematic search of PubMed, Scopus, Embase, Web of Science, and Google Scholar identified articles published between December 2019 and August 2022. Risk of bias was evaluated …


Prioritization Among School Nurses: An Integrative Review Of The Literature, Melissa Calvillo, Susana J. Calderon, Maureen Rabbitte, Cherrill Stockmann, Sheryl Henry Jan 2025

Prioritization Among School Nurses: An Integrative Review Of The Literature, Melissa Calvillo, Susana J. Calderon, Maureen Rabbitte, Cherrill Stockmann, Sheryl Henry

Faculty Publications - Mennonite College of Nursing

With a median caseload of 750–1,000 clients, school nurses face setting-specific challenges involving multiple, competing demands. This necessitates effective prioritization to prevent missed opportunities to provide appropriate care. This integrative review synthesizes the current state of the literature related to prioritization among school nurses in the United States. Three themes were identified relating to prioritization among school nursing: knowledge, attitudes and values; self-efficacy and intention to act; and the nursing process. The prioritization behavior of school nurses can be facilitated by organizational and community collaboration and strong evidence-based practice recommendations. High workloads and inadequate resources among school nurses are the …


Digital Health Literacy On Diabetes Knowledge Among Older Adults In The United States, Jung Eun Kim, Susana J. Calderon, Myoungjin Kim Jan 2025

Digital Health Literacy On Diabetes Knowledge Among Older Adults In The United States, Jung Eun Kim, Susana J. Calderon, Myoungjin Kim

Faculty Publications - Mennonite College of Nursing

Purpose

This study examines the relationship between selected socio-demographics and digital health literacy on diabetes knowledge among older adults in the United States.

Design

Cross-sectional study

Methods

The eHealth Literacy Scale and the Short Diabetes Knowledge Instrument were used. Descriptive statistics, Pearson’s r, point-biserial correlation coefficient, Kendall’s tau, ANOVA, and Poisson regression were used for data analysis.

Findings

The mean age was 71. The mean sum score for digital health literacy was 28.32 (SD = 7.95; range, 8–40), and the mean score for diabetes knowledge was 8.8 (SD = 2.3; range, 2–13). The education level, annual income, number of digital …


Role Call: Can A Backbench Legislator Practice As A Criminal Defence Lawyer? A Legal Ethics Analysis, Andrew Flavelle Martin, Brandon Trask Jan 2025

Role Call: Can A Backbench Legislator Practice As A Criminal Defence Lawyer? A Legal Ethics Analysis, Andrew Flavelle Martin, Brandon Trask

Articles, Book Chapters, & Popular Press

Legislators come from a range of backgrounds. Many legislators happen to be lawyers. Parliamentary rules typically allow legislators who are not members of Cabinet to practice a profession part-time. However, the part-time practice of law poses special legal ethics challenges. In this article, we consider the legal ethics issues that arise when a backbench legislator of the governing party practices criminal defence law part-time. We argue that such a dual role engages three serious, unavoidable, and perhaps even unresolvable legal ethics issues. The first issue is the time constraints imposed by outside interests. The second issue is conflicts of interest, …


Copyright In The Age Of Artificial Intelligence: Navigating Access To Algorithmic Training Materials And The Three‐Step Test For Text And Data Mining In Nigeria, Morris Odeh Jan 2025

Copyright In The Age Of Artificial Intelligence: Navigating Access To Algorithmic Training Materials And The Three‐Step Test For Text And Data Mining In Nigeria, Morris Odeh

Articles, Book Chapters, & Popular Press

Over the past decade, the Nigerian government has sought to leverage Artificial Intelligence (AI) to drive socioeconomic transformation and improve the welfare of its citizenry. Recent initiatives, such as the establishment of the National Centre for AI and Robotics (NCAIR) and the development of several strategic AI policies, highlight the country's commitment to this objective. This article explores the often‐overlooked issue of how the Nigeria's copyright regime hinders these initiatives, revealing that the regime permits only fair dealing and the transient or incidental reproductions of copyrighted materials for limited technological purposes. This study argues that this regime is unduly restrictive …


Sentencing Vulnerability: Conceptualizing The Incorporation Of Personal Characteristics And Experiences At Sentencing, Adelina Iftene Jan 2025

Sentencing Vulnerability: Conceptualizing The Incorporation Of Personal Characteristics And Experiences At Sentencing, Adelina Iftene

Articles, Book Chapters, & Popular Press

Social inequalities that lead to criminal conduct are often not considered in sentencing; individuals subject to structural inequities receive the same formal sentence as those convicted of like crimes irrespective of the latter’s social advantage. Individual characteristics may also affect how a sentence will be experienced by an individual. While Characteristics and Experience-Sensitive Sentencing (CESS) already exists in various forms and to various degrees in sentencing theory and praxis, a more cohesive, comprehensive, and principled CESS remains wanting. Building on existing approaches, this article locates CESS as a necessary response to equality-based concerns arising from current mainstream sentencing practice. Thus, …


“I’M Not Really Sure Of What Exists Here”: Frontline Perspectives On Services For Technology-Facilitated Sexual Violence, Jennifer L. Mcarthur, Kayla J. Goruk, Julie Blais, Alexa Dodge, Suzie Dunn Jan 2025

“I’M Not Really Sure Of What Exists Here”: Frontline Perspectives On Services For Technology-Facilitated Sexual Violence, Jennifer L. Mcarthur, Kayla J. Goruk, Julie Blais, Alexa Dodge, Suzie Dunn

Articles, Book Chapters, & Popular Press

Technology-facilitated sexual violence (TFSV) is a pervasive issue, yet research on the availability, accessibility, and effectiveness of services for TFSV victimsurvivors remains limited, particularly in Canada. This qualitative study examines the state of service provision for TFSV in Nova Scotia, drawing on insights from 12 interviews with service providers specializing in sexual violence prevention and response. The study explores the availability and nature of services offered to TFSV victim-survivors and the key challenges faced by professionals in providing support. Thematic analysis highlights significant gaps in service provision, including a reliance on generalized approaches, restrictive eligibility criteria that exclude certain victimsurvivors, …


Determination Of Structural Factors Contributing To Protection Of Zinc Fingers In Estrogen Receptor Α Through Molecular Dynamic Simulations, Patricia B. Lutz, Wesley R. Coombs, Craig A. Bayse Jan 2025

Determination Of Structural Factors Contributing To Protection Of Zinc Fingers In Estrogen Receptor Α Through Molecular Dynamic Simulations, Patricia B. Lutz, Wesley R. Coombs, Craig A. Bayse

Chemistry & Biochemistry Faculty Publications

The ERα transcription factor that induces tumor growth is a potential target for breast cancer treatment. Each monomer of the ERα DNA-binding domain (ERαDBD) homodimer has two conserved (Cys)4-type zinc fingers, ZF1 (N-terminal) and ZF2 (C-terminal). Electrophilic agents release Zn2+ by oxidizing the coordinating Cys of the more labile ZF2 to inhibit dimerization and DNA binding. Microsecond-length molecular dynamics (MD) simulations show that greater flexibility of ZF2 in the ERαDBD monomer leaves its Cys more solvent accessible and less shielded from electrophilic attack by sulfur-centered hydrogen bonds than ZF1 which is buried in the protein. In the …


Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim Jan 2025

Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim

Chemistry & Biochemistry Faculty Publications

Adansonia digitata and Annona muricata are traditionally used medicinal plants with reported pharmacological properties. In this study, we aimed to elucidate the phytochemical composition, antioxidant activity, and antibacterial properties of partition fractions of Adansonia digitata and Annona muricata extracts obtained using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. The plant extracts were successively partitioned using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. Phytochemical analysis was performed using standard methods. Antioxidant activity was evaluated using FRAP and DPPH assays. Antibacterial activity was assessed using agar well diffusion and MIC determination. Phytochemical analysis revealed the presence of alkaloids (10.2-15.6%), flavonoids …


The Importance Of Solution Studies For The Structural Characterization Of The Enterovirus 5' Cloverleaf, Morgan G. Daniels, Meagan E. Werner, Xiaobing Zuo, Steven M. Pascal Jan 2025

The Importance Of Solution Studies For The Structural Characterization Of The Enterovirus 5' Cloverleaf, Morgan G. Daniels, Meagan E. Werner, Xiaobing Zuo, Steven M. Pascal

Chemistry & Biochemistry Faculty Publications

Enteroviruses initiate genomic replication via a highly conserved mechanism that is controlled by an RNA platform, also known as the 5' cloverleaf (5'CL). Here, we present a biophysical analysis of the 5'CL conformation of three enterovirus serotypes under various ionic conditions, utilizing CD spectroscopy, size-exclusion chromatography, and small-angle X-ray scattering. In general, a tendency toward a smaller monomeric hydrodynamic radius in the presence of salts was observed, but the exact structural signature of each 5'CL varied depending upon the serotype. Rhinovirus B14 (RVB14) exhibited at least two monomeric conformations and a low propensity for dimerization, while poliovirus 1 (PV1) showed …


Investigation Of Sleep Disorders And Related Influencing Factors Among The Elderly In Southeast Coastal Regions Of China: A Cross-Sectional Survey Analysis, Yaopian Chen, Fu Su, Haixia Xiang, Jinhong Xia Jan 2025

Investigation Of Sleep Disorders And Related Influencing Factors Among The Elderly In Southeast Coastal Regions Of China: A Cross-Sectional Survey Analysis, Yaopian Chen, Fu Su, Haixia Xiang, Jinhong Xia

Student Publications [Scholarly]

Objective: To assess the sleep status and prevalence rate of the elderly in southeast coastal areas of China, and analyze related factors. Methods: A questionnaire survey was conducted among elderly individuals in Wenzhou City, Zhejiang Province, situated in the southeast coastal areas of China, using a multi-stage random sampling method. A total of 903 elderly people aged ≥ 60 years were selected for the survey. The questionnaire aimed to assess their sleep status using PSQI and to evaluate related factors using Self-designed General Information and Health Behavior Questionnaires, SAS, GDS-15, ESS, AD8, SHAP, WHOQOL-BREF, among other tools. Logistic regression was …


Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad Jan 2025

Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad

Mansoura Medical Journal

Background Schistosomiasis is a prevalent fibrotic disease characterized by inflammation and fibrous tissue deposition around Schistosoma eggs trapped in the hepatic tissue. This work aimed to evaluate the anti-fibrotic and anti-parasitic effects of fucoidan during the chronic phase of experimental schistosomiasis-mansoni in mice. Methods Sixty female Swiss albino mice were allocated into six groups; non-infected unmanaged mice group, infected unmanaged mice group, non-infected fucoidanmanaged mice group, infected fucoidan-managed mice group, infected PZQ-managed mice group, and infected combined fucoidan and PZQ managed mice. Every liver tissue was examined parasitologically, histopathologically, and by anti-transforming growth factor-beta (TGF-β) immunohistochemically. Serum was used to …


Application Of Milan System In Cytological Diagnosis Of Salivary Gland Lesions And Its Association With Histopathology, Asmaa Sabry Gad, Heba Salah Eldin Hany, Wagdi Fawzi Elkashef, Mie Ali Mohamed Jan 2025

Application Of Milan System In Cytological Diagnosis Of Salivary Gland Lesions And Its Association With Histopathology, Asmaa Sabry Gad, Heba Salah Eldin Hany, Wagdi Fawzi Elkashef, Mie Ali Mohamed

Mansoura Medical Journal

Background: Salivary gland harbors a wide variety of non-neoplastic & neoplastic conditions that show heterogenicity in the same tumor tissue. The Milan System for Reporting Salivary Gland Cytology was designated to offer a standardized universally accepted reporting format for Salivary Gland FNAC. Aim: To apply Milan system for salivary gland and assess its accuracy by comparing the cytology and histopathology. Methods: In this retrospective study, the Milan system was applied on 81 FNAC cases referred to pathology lab at Oncology Centre Mansoura University during 5 years & compared results with postoperative biopsy. For cytological samples, Hematoxylin & Eosin-stained smears, cell …


St-Segment Resolution As A Predictor Of Short-Term Clinical Outcomes In Patients With Acute Anterior St-Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention, Mohamed Ali Nada, Eid Mohamed Daoud, Ahmed Mohamed Reda Jan 2025

St-Segment Resolution As A Predictor Of Short-Term Clinical Outcomes In Patients With Acute Anterior St-Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention, Mohamed Ali Nada, Eid Mohamed Daoud, Ahmed Mohamed Reda

Mansoura Medical Journal

Background: Acute anterior ST-elevation myocardial infarction (STEMI) carries a high risk of adverse outcomes despite advances in reperfusion therapy. ST-segment resolution (STR) on electrocardiography has been proposed as a simple marker of myocardial reperfusion and predictor of clinical, but its prognostic role in routine practice remains debated. Aim of the Work: To assess the efficacy of ST-segment resolution as a predictor of short-term clinical outcomes in patients with acute anterior STEMI undergoing primary percutaneous coronary intervention (PCI). Patients and Methods: A prospective observational study was conducted at Mansoura University Cardiology Department between January and June 2024. 98 patients with anterior …


Interleukin-38 Serum Level In Nonsegmental Vitiligo Patients And Its Correlation With Disease Activity And Disease Severity, Aya Adel, Mohammed El- Kamel, Manar Ali Hassan Jan 2025

Interleukin-38 Serum Level In Nonsegmental Vitiligo Patients And Its Correlation With Disease Activity And Disease Severity, Aya Adel, Mohammed El- Kamel, Manar Ali Hassan

Mansoura Medical Journal

Background Vitiligo is a multifactorial disease in which autoimmunity plays a central role. Interleukin (IL)-38, an innate immune cytokine secreted by keratinocytes and other cells, is believed to have a role in vitiligo progression. Aim To assess the serum levels of IL-38 in cases with non-segmental vitiligo and to examine its correlation to disease severity and disease activity. Methods This case control study included 60 patients with vitiligo and 20 healthy subjects as a control group. According to the disease severity, the cases were allocated into three groups: mild, moderate and severe. Each group included 20 patients. The affected body …


The Use Of Coronary Sinus Diameter Measurements To Distinguish Atrioventricular Nodal Reentrant Tachycardia From Atrioventricular Reentrant Tachycardia, Mohamed Ibrahim Ataalla Khalil, Sherif Abd El Salam Sakr, Hany Mahmoud Abd Elshakour, Hoda Mohamed Sobh Jan 2025

The Use Of Coronary Sinus Diameter Measurements To Distinguish Atrioventricular Nodal Reentrant Tachycardia From Atrioventricular Reentrant Tachycardia, Mohamed Ibrahim Ataalla Khalil, Sherif Abd El Salam Sakr, Hany Mahmoud Abd Elshakour, Hoda Mohamed Sobh

Mansoura Medical Journal

Background: Supraventricular tachycardia (SVT) is a common clinical arrhythmia, with atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT) being the most frequent subtypes. Distinguishing between these arrhythmias is crucial for determining the appropriate treatment strategy. Aim: To evaluate the clinical utility of echocardiographic measurement of coronary sinus (CS) diameter in distinguishing AVNRT from AVRT. Methods: This prospective descriptive study included 54 patients with narrow complex tachycardia who underwent echocardiography then electrophysiology study (EPS). CS diameter was measured at the ostium and 1 cm distal using 2D echocardiography then CS ostium area by 4D echocardiography was measured. Results: Patients …


The Impact Of Effective Diabetes Management On Reducing Burden In Elderly Patients: A Case-Control Study, Eslam Abdelhamid Mohamed, Mohamed A. Helaly, Ahmed Albehairy Jan 2025

The Impact Of Effective Diabetes Management On Reducing Burden In Elderly Patients: A Case-Control Study, Eslam Abdelhamid Mohamed, Mohamed A. Helaly, Ahmed Albehairy

Mansoura Medical Journal

Background and aim: Elderly individuals with diabetes mellitus (DM) are more prone to experiencing common geriatric syndromes, which include impaired cognition, dementia, frailty, falls, fractures, urinary incontinence, and disability. These can significantly impair their quality of life (QoL) and could conflict with anti-diabetic medication. Therefore, we aim to evaluate the impact of controlling diabetes on the overall burden of diabetes in the elderly. Materials and Methods: 100 elderly patients over sixty-five with type 2 diabetes mellitus (T2DM) were selected from Mansoura Specialized Medical Hospital (MSMH) between April 2022 and February 2023. The patients were divided into two groups: fifty diabetic …


Could Angiopioetin-1 & Angiopioetin-2 Be Considered A Predictor For Community Acquired Pneumonia Severity And Phenotypes, Magdy Mohamed Zedan, Nashwa Abusamra, Engy Osman, Rania Mohammed Emad Eldin Eldersy Jan 2025

Could Angiopioetin-1 & Angiopioetin-2 Be Considered A Predictor For Community Acquired Pneumonia Severity And Phenotypes, Magdy Mohamed Zedan, Nashwa Abusamra, Engy Osman, Rania Mohammed Emad Eldin Eldersy

Mansoura Medical Journal

Background: Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide and the role of biomarkers in pneumonia has been evaluated in many clinical areas. Angiopoietin-1 and Angiopoietin -2 are glycoproteins that play role in vascular development, angiogenesis, and permeability. Aim: To conduct a trial for phenotyping and endotyping of pneumonia using Angiopoietins-1 and Angiopoietin -2. Subjects and methods: This case-control study included 30 cases and 29 controls of matched age and sex. to investigate Angiopioetin-1 & -2 serum levels in both groups and then evaluated the possible association between serum Angiopoietin -1&-2 in different pneumonia phenotypes. Results: …


Aprepitant Ameliorates Cyclophosphamide-Induced Testicular Toxicity In Mice Via Suppression Of P38 Mitogen-Activated Protein Kinase, Suzan Awad Abdelghany Morsy, Amira H. Eltrawy, Nehal Adel Khalil, Abd Elaziz Mm, Nourhan Mohamed Mohamed Saeed, Gehad M. Khamis Jan 2025

Aprepitant Ameliorates Cyclophosphamide-Induced Testicular Toxicity In Mice Via Suppression Of P38 Mitogen-Activated Protein Kinase, Suzan Awad Abdelghany Morsy, Amira H. Eltrawy, Nehal Adel Khalil, Abd Elaziz Mm, Nourhan Mohamed Mohamed Saeed, Gehad M. Khamis

Mansoura Medical Journal

Background: While cyclophosphamide (CP) is a commonly used immunosuppressant and anticancer drug, it has a high risk of testicular toxicity. The current study evaluated the protective and therapeutic actions of aprepitant (APR), a neurokinin-1 receptor blocker, against CP-induced testicular toxicity in mice and the role of oxidative stress and phosphorylated P38 mitogen-activated protein kinase (p-P38 MAPK) in this action.Methods: Forty male mice were assigned to four groups: control (vehicle only), CP-induced testicular toxicity (single 200 mg/kg intraperitoneal CP dose), APRprotected (20 mg/kg/day APR starting one day before CP, continued for 30 days), and APR-treated (same APR dose starting one hour …


Factors Affecting In-Hospital Mortality After Sudden Cardiac Arrest In The Emergency Department: A Retrospective Cohort Study, Erkan Boğa, Abdullah Algın Jan 2025

Factors Affecting In-Hospital Mortality After Sudden Cardiac Arrest In The Emergency Department: A Retrospective Cohort Study, Erkan Boğa, Abdullah Algın

Mansoura Medical Journal

Giriş: Ani kalp hastalıkları (SCA), özellikle acil serviste (AS) yüksek hastane içi ölüm tutarları ve önemli bir tıbbi acil durumları. Prognostik bilgilerin belirlenmesi, sonuçların değiştirilmesi için çok önemlidir. Amaç: Acil serviste SCA'lı hastane içi ölümle sağlanan klinik ve demografik oranların belirlenmesi. Yöntemler: Bu retrospektif kohort çalışmaları Ocak 2023 ile Aralık 2024 arasında üçüncü basamaktaki bir hastanenin AS'sinde SCA'nın 345 yıl boyunca geçirdiği süre dahil edildi. Demografik özellikler, türü olmayan yayılma, durma özellikleri, resüsitasyon süresi, laboratuvar gelişimi ve patoloji durumuyla ilgili veriler toplandı. Bağımsız ölüm öngörmelerini belirlemek için lojistik regresyon kaydı. Sonuçlar: Hastane içi ölüm %38,3 idi. Çok değişkenli analiz, resüsitasyon …


Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy Jan 2025

Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy

Mansoura Medical Journal

Background Laryngotracheal reconstruction (LTR) is a well-established surgical procedure for the management of pediatric subglottic stenosis, with rib cartilage grafts. This study was conducted to evaluate preoperative and intraoperative discrepancies of rib graft used in laryngotracheal reconstruction using ultrasonic criteria in terms of their height, thickness, and length. Methods This prospective cohort study was conducted on 10 pediatric patients who underwent LTR at Mansoura University Hospitals. Preoperative ultrasonography was performed on the right 4th, 5th, and 6th rib cartilages, measuring height, thickness, and length. These measurements were then directly compared with intraoperative dimensions of the harvested cartilage. Results There was …


Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy Jan 2025

Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy

Mansoura Medical Journal

Background The role of vitamin D in the pathogenesis of rheumatoid arthritis is controversial. This study aims to assess the relation between vitamin D level and rheumatoid arthritis disease activity. Patients and methods This study was conducted on 80 rheumatoid arthritis (RA) patients beside 40 healthy persons. Vitamin D level was assessed in all participants. Rheumatoid activity was assessed using DAS28 (disease activity score). RA patients were classified according to DAS 28 into two groups: active group and remission group. Results The median for vitamin D level in RA group was 23.5ng/ml. There was no statistically significant difference in serum …