Digital Commons Network^™

Intravaginal Cooling Provides Symptom Relief In Women With Vulvovaginal Candidiasis And Reduces Immunopathology In An Accompanying Mouse Model, Junko Yano, Kimberly Langdon, Michael Swor, Mairi C. Noverr, Paul L. Fidel

School of Dentistry Faculty Publications

BACKGROUND: Vulvovaginal candidiasis (VVC), caused primarily by Candida albicans, is currently treated with either prescription or over-the-counter antifungal drugs, often with variable efficacy and relapses. New and improved therapeutic strategies, including drug-free treatment alternatives, are needed. Upon overgrowth or environmental triggers, C. albicans yeast transitions into hyphae that results in an aberrant immunopathologic response by neutrophils, contributing to the characteristic vulvovaginal symptoms. The purpose of this study was to evaluate the efficacy of a patented intravaginal cooling device (Vlisse®) to provide symptom relief in women with VVC via putative reversal of C. albicans hyphae to the commensal yeast form, with …

State Of Utah, Plaintiff/ Appellee V. Celestine Anastacia Torstenson, Defendant/ Appellant : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from a conviction for aggravated assault, a third - degree felony, in the Second Judicial District, Weber County, the Honorable Joseph M. Bean presiding

WILLIAM M. HAINS, DEREK BROWN, MATTHEW EARL, Counsel for Appellee

The Functional Fitness Of The Community Dwelling Older Adults In Shan Dong Of Mainland China In Comparison With The Population In Hong Kong, Zongtao Li, Yu Teng, Huigang Wang, Hao Liu, Lei Zhao

International Journal of Physical Activity and Health

Purpose: To compare the functional fitness (FF) of the community dwelling older adults in Shan Dong (SD) of mainland China with their peers in Hong Kong (HK). Methods: 1887 older adults living in SD were measured with Senior Fitness Test (SFT) One sample T test was used to determine the age grooup difference in each FF component between the population of SD and HK. Results: Compared with their HK peers, SD older adults showed higher performance in the task of 30s arm curl, but lower abilities in 30s chair stand, back scratch, chair sit & reach, and 8 ft …

Students' Perceived Value And Emotions In Turkish Physical Education: Testing Moderation By Gender And Sports Involvement, Mehmet Ceylan, Kelly L. Simonton

International Journal of Physical Activity and Health

Physical Education (PE) has been recognized as a key element in developing student enjoyment for physical activity and healthy lifestyle habits. Student emotions may dictate learning and motivation, but less is known regarding the perceptions of value and control that shape these emotions. Specifically, within certain K-12 PE national curriculums and cultures, the goals and objectives of PE, along with its emphasis on physical activity and sport, may influence the emotional response of students and their perceived value of PE. If students feel a lack of value, negative emotions, and marginalized by the content then it is unlikely their experiences …

Mental Health Conditions Of Adults With Chronic Obstructive Pulmonary Disease And Comorbidities, Amanda M. Hinson-Enslin, Luis E. Espinoza, Jennifer L. Talleff

Journal of Social, Behavioral, and Health Sciences

Although the association is not well understood, people with COPD are likely to suffer from mental health issues such as depression and anxiety. Due to this occurrence, the aim of the present study is to better understand the mental health experience and COPD comorbidities of U.S. adults with a COPD diagnosis. The final sample comprised 1,676 U.S. adults who were surveyed in the 2019 National Health Interview Survey adult public file. Logistic and ordinal regression were used to calculate adjusted odds ratios for comorbid conditions predicting depression, anxiety, and the number of mental health issues, respectively. Depressive symptoms were more …

Uncovering The Binding Mechanism Of Mutated Omicron Variants Via Computational Strategies, Sajjad Haider, Nadeem Ahmad, Muhammad Shafiq, Ali Raza Siddiqui, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has resulted in nearly 630 million cases and 6.60 million fatalities globally, as of November 2022. SARS-CoV-2, a species of the Coronaviridae family, has a single-stranded positive-sense RNA genome as well as four main structural proteins (S, E, M, and N) required for viral entrance into target cells. The spike protein (S) influences this entry through interactions with human angiotensin-converting enzyme 2 (hACE2) receptor. The World Health Organization (WHO) recognized numerous variants of concern (VOCs) that involve Alpha, Beta, Gamma, Delta, and Omicron, having multiple mutations within the spike protein, altering infection …

Antibacterial And Antifungal Activities Of Linear And Cyclic Peptides Containing Arginine, Tryptophan, And Diphenylalanine, David Salehi, Eman H. M. Mohammed, Naiera M. Helmy, Keykavous Parang

Pharmacy Faculty Articles and Research

Background. We have previously reported peptides composed of sequential arginine (R) residues paired with tryptophan (W) or 3,3-diphenyl-L-alanine residues (Dip), such as cyclic peptides [R4W4] and [R4(Dip)3], as antibacterial agents. Results. Herein, we report antibacterial and antifungal activities of five linear peptides, namely ((DipR)4(WR)), ((DipR)3(WR)2), ((DipR)2(WR)3), ((DipR)(WR)4), and (DipR)4R, and five cyclic peptides [(DipR)4(WR)], [(DipR)3(WR)2], [(DipR)2(WR)3], [(DipR)(WR)4], and [DipR]5, containing alternate positively charged R and hydrophobic W and Dip residues against fungal, Gram-positive, and Gram-negative bacterial pathogens. The minimum inhibitory concentrations (MICs) of all peptides were determined by the micro-broth dilution method against Methicillin-Resistant Staphylococcus aureus, Klebsiella pneumoniae, …

Infiltrating Plasma Cells Maintain Glioblastoma Stem Cells Through Igg-Tumor Binding, Jiancheng Gao, Danling Gu, Kailin Yang, Junxia Zhang, Qiankun Lin, Wei Yuan, Xu Zhu, Deobrat Dixit, Ryan C Gimple, Hao You, Qian Zhang, Zhumei Shi, Xiao Fan, Qiulian Wu, Chenfei Lu, Zhangchun Cheng, Daqi Li, Linjie Zhao, Bin Xue, Zhu Zhu, Zhe Zhu, Hui Yang, Ningwei Zhao, Wei Gao, Yingmei Lu, Junfei Shao, Chuandong Cheng, Dapeng Hao, Shuo Yang, Yun Chen, Xiaoming Wang, Chunsheng Kang, Jing Ji, Jianghong Man, Sameer Agnihotri, Qianghu Wang, Fan Lin, Xu Qian, Stephen C Mack, Zhibin Hu, Chaojun Li, Michael D Taylor, Yan Li, Nu Zhang, Jeremy N Rich, Yongping You, Xiuxing Wang

Faculty, Staff and Students Publications

Glioblastoma is a highly aggressive primary brain tumor with glioblastoma stem cells (GSCs) enforcing the intra-tumoral hierarchy. Plasma cells (PCs) are critical effectors of the B-lineage immune system, but their roles in glioblastoma remain largely unexplored. Here, we leverage single-cell RNA and B cell receptor sequencing of tumor-infiltrating B-lineage cells and reveal that PCs are aberrantly enriched in the glioblastoma-infiltrating B-lineage population, experience low level of somatic hypermutation, and are associated with poor prognosis. PCs secrete immunoglobulin G (IgG), which stimulates GSC proliferation via the IgG-FcγRIIA-AKT-mTOR axis. Disruption of IgG-FcγRIIA paracrine communication inhibits GSC proliferation and self-renewal. Glioblastoma-infiltrating PCs are …

Meta-Analysis Of Dedicated Vs Off-Label Transcatheter Devices For Native Aortic Regurgitation, Sahar Samimi, Taha Hatab, Chloe Kharsa, Safi U Khan, Rody G Bou Chaaya, Fatima Qamar, Joe Aoun, Syed Zaid, Nadeen Faza, Marvin D Atkins, Stephen H Little, William A Zoghbi, Michael J Reardon, Neal S Kleiman, Sachin S Goel

Faculty, Staff and Students Publications

Background: Transcatheter aortic valve replacement (TAVR) for high surgical risk patients with severe native aortic regurgitation (AR) presents unique challenges. Dedicated devices such as the JenaValve (JenaValve Technology) and J-Valve (JC Medical Inc) show promising results in addressing these challenges.

Objectives: This study compares the safety and efficacy of dedicated vs off-label devices among high surgical risk patients with pure native AR.

Methods: We systematically searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials through July 11, 2024, for studies on TAVR among patients with pure severe native AR. The primary endpoint was 30-day all-cause mortality. Secondary endpoints were …

Lipid Nanoparticles Deliver Dna-Encoded Biologics And Induce Potent Protective Immunity, Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H Young, Yong Li

Faculty, Staff and Students Publications

Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinical challenges. This study compared various LNP formulations for delivering DNA-encoded biologics, assessing their expression efficacy and the protective immunity generated by LNP-encapsulated DNA in different models. The LNP formulation used in Moderna's Spikevax mRNA vaccine (LNP-M) demonstrated a stable nanoparticle structure, high expression efficiency, and low toxicity. Notably, a DNA vaccine encoding the spike protein, delivered via LNP-M, induced stronger antigen-specific antibody and T cell immune responses compared to electroporation. Single-cell RNA sequencing (scRNA-seq) analysis revealed that the LNP-M/pSpike vaccine enhanced CD80 activation signaling …

Tolerance Of Cotton To Herbicide-Coated Fertilizers, L. Summer Linn, Jason K. Norsworthy, Pamela Carvalho-Moore, Tristen H. Avent, Tom Barber, Trenton L. Roberts, Ben Trash

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Cotton producers need residual herbicides that can safely and practically be applied postemergence. Herbicide-coated fertilizers could allow for simultaneous application of residual herbicides and a bulk fertilizer blend. Therefore, a study was conducted in 2022 and 2023 in Fayetteville, AR, to evaluate cotton tolerance to 12 herbicide treatments coated onto a fertilizer blend and applied over cotton. Herbicides and rates evaluated included diuron at 840 g ai ha-1, florpyrauxifen-benzyl at 29 g ai ha-1, flumioxazin at 105 g ai ha-1, flumioxazin + pyroxasulfone at 70 + 90 g ai ha-1, fluridone at 168 g ai ha-1, fluometuron at 840 g …

Identification And Characterization Of A Novel Pavlovskyella (Acari: Argasidae) From Chile, Parasite Of The Culpeo Fox (Lycalopex Culpaeus), Sebastián Muñoz-Leal, Alexander R Kneubehl, Karen Ardiles, Catalina Parragué-Migone, Ignacio Troncoso-Toro, Pablo Oyarzún-Ruiz, Job E Lopez

Faculty, Staff and Students Publications

Soft ticks (Argasidae) of the subgenus Pavlovskyella Pospelova-Shtrom are worldwide distributed parasites of medical importance. However, the systematics of the subgenus are currently under debate because genetic data shows that the group is paraphyletic. Meanwhile, species of Pavlovskyella continue to be discovered. In this study a novel species of the subgenus is described from specimens collected on a fox in central Chile. The larva of this new species differentiates from other Pavlovskyella spp. by having the following combination of characters: subpyriform dorsal plate; 15 pairs of setae, 7 anterolateral, 3 central, and 5 posterolateral, and hypostome with denticles in the …

Economic Evaluations Of Artificial Intelligence Implementation In Diabetic Retinopathy Screening, Ahmad Ahmad, Neily Zakiyah, Auliya A. Suwantika

Pharmacology and Clinical Pharmacy Research

Diabetic retinopathy (DR) is a common complication of diabetes that damages retinal blood vessels and can lead to vision impairment. The application of Artificial Intelligence (AI) in DR screening offers a promising alternative to conventional methods. However, further research is crucial to determine the cost-effectiveness of this intervention.This study systematically reviewed economic evaluations of AI interventions in DR screening using data from PubMed and ScienceDirect (2014–2023). Studies in various healthcare settings assessing cost-effectiveness outcomes, such as incremental cost-effectiveness ratio (ICER) and net monetary benefit, were included. The CHEERS (Consolidated Health Economic Evaluation Reporting Standards) checklist was used to assess the …

The Valemee Visual System Helps Reduce Risk For Chronic Illness By Promoting Physical Fitness, Self-Efficacy And Independence In Adults With Intellectual Disabilities, Anthony Dujmovic-Bračak, Alisa Blazek, Emily Post, Jacqueline Goodway, Carmen Swain

All Faculty and Staff Scholarship

Introduction
Sedentary behaviour among individuals with intellectual disabilities, driven by barriers such as limited access to adapted programs and low self‐efficacy, contributes to chronic health conditions. This study evaluates the effectiveness of the Valemee Visual System (VVS), a novel tool offering visual support and structured exercise programming, in improving physical fitness and promoting exercise independence in this population.

Methods
A repeated measures design was employed with an 8‐week intervention involving 22 participants aged 22–44 with mild to moderate intellectual disabilities. The program utilised the VVS for total body fitness training.

Results
Participants demonstrated significant improvements in grip strength, sit‐to‐stand performance, …

Exploring Interpersonal, Sexual, And Moral Development Of Offending Clergy, Aaron Andrew Ghering

Walden Dissertations and Doctoral Studies

This study explored the lived experiences of offender clergy through their childhood development. It specifically looked at the social, moral, and sexual development of these individuals. This phenomenological qualitative study provided insight into what, if anything, in their early moral, social, and sexual development could help shed light on their future behaviors and actions. Bandura’s Social Learning Theory guided this study by providing an understanding of how social learning throughout development can influence the formation of social, moral, and sexual behaviors later in life. The data were collected from reviewing existing material from existing diaries, interviews, and previously published studies. …

Jordanian Women's Perception Of The Discrepancy Between Education And Access To Labor Market, Rana El Khawand

Walden Dissertations and Doctoral Studies

This study is an examination of the perceptions of educated Jordanian women regarding the gap between their high educational attainment and limited access to the labor market, focusing on systemic sociocultural, institutional, and economic barriers. Targeting women in science, technology, engineering, and mathematics (STEM) fields, the study was conducted using a feminist theoretical framework emphasizing societal norms, power imbalances, and institutional inequities as critical factors shaping women’s professional experiences. A generic qualitative design was employed, collecting data through semistructured interviews and SenseMaker narratives from four faculty members at a Jordanian university. Thematic coding, discourse analysis, and sentiment analysis were used …

Exploring School Leaders’ Experiences Allocating Financial Resources To Support Technology Integration Learning, Joshua Armstrong

Walden Dissertations and Doctoral Studies

America's local education agencies (LEAs) often struggle with technology integration learning (TIL). There is a lack of understanding about how leadership is planning and financially managing the allocation of budgeted dollars to support TIL. The purpose of this phenomenological study was to explore the lived experiences of public school leaders involved with financial management and the planning of resources to support TIL. Mishra’s and Koehler’s technological, pedagogical, and content knowledge framework grounded this study on how leadership planning and financial management affect teachers’ technological skills and professional development when incorporating TIL in public schools. Data were collected through 11 semistructured …

Development Of 'Me And You' Model For Emotional And Behavioral Disorders In Children: A Joyful Approach, Siti Nuraini Purnamawati, Hartini Nara, Rohmah Ageng Mursita, Lintang Al Mar’Atus Sholihah

Journal of ICSAR

This research focuses on the development of the "Me and You" learning model for children with emotional and behavioral disorders (EBD), especially those from socioeconomically disadvantaged environments, such as the Rusunawa Jatinegara Kaum area in East Jakarta. Using the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), the study employed a systematic, evidence-based approach to create and refine an effective educational intervention. The model, organized around five core themes addressing self-awareness, emotional regulation, and social interaction, aims to reduce misunderstandings and foster positive peer relationships. The intervention was tested in a community setting, and expert validation was conducted. Findings suggest that …

Web Lexiroom As A Media For Teacher Social Competency Training Based On Gesi In Indonesia, Tita Rosita, Sukinah Sukinah, Devy Sekar Ayu Ningrum, Muhammad Rezza Septian

Journal of ICSAR

The purpose of this research is to develop the Lexiroom web as a medium for training the social competence of elementary school teachers based on GESI (Gender Equality and Social Inclusion). The social competence of teachers that will be improved is in the aspects of attitudes towards inclusive education, empathy, and problem solving. The research method used is Research and Development, with the ADDIE model. The research sample is 39 teachers who teach in four locations of public elementary schools in Bandung City, Indonesia. Based on the validation results of three experts in terms of the content of training materials, …

Mobile Application Development For Android: Identification Tool For Children With Special Needs In Inclusive Schools, Mirnawati Mirnawati, Amka Amka

Journal of ICSAR

This research aims to develop an Android-based mobile application that acts as an identification tool for children with special needs. By using mobile technology, this application will facilitate the identification process for teachers and parents and provide clear guidelines for its use. This research method uses the R & D (Research and Development) ADDIE design, which consists of five stages, namely analysis, design, development, implementation and evaluation. Identification is carried out by filling in data on the application, with the dominant characteristics appearing after the data has been filled in. The identification process is based on the results of a …

Implementation Of Pictorial Test Instruments To Improve Deaf Students' Sexual Behavior Knowledge Through Direct Learning, Budi Susetyo, Iding Tarsidi, Wiwi Siswaningsih, Andily Aprilia Rahmawati, Nuning Sapta Rahayu, Tati Hernawati

Journal of ICSAR

Adolescents with disability are vulnerable to sexual violence, due to their limitations. This study aims to improve knowledge and understanding of sexual behavior of deaf students by using test instrument in the form of images in direct learning, so it can overcome deviant sexual behavior. The research method used was an experiment with a one group posttest experimental design, the research sample was 22 deaf students of SMPLB and SMALB in the West Java and Bali. The test instrument in the form of choices was equipped with images consisting of four aspects, namely the anatomy and function of reproductive organs, …

Nerves At Play: The Peripheral Nervous System In Extracranial Malignancies, Paola D Vermeer, Anthony C Restaino, Jeffrey L Barr, Dan Yaniv, Moran Amit

Faculty, Staff and Student Publications

The exponential growth of the cancer neuroscience field has shown that the host's immune, vascular, and nervous systems communicate with and influence each other in the tumor microenvironment, dictating the cancer malignant phenotype. Unraveling the nervous system's contributions toward this phenotype brings us closer to cancer cures. In this review, we summarize the peripheral nervous system's contributions to cancer. We highlight the effects of nerve recruitment and tumor innervation, the neuro-immune axis, glial cell activity, and neural regulation on cancer development and progression. We also discuss harnessing the neural control of peripheral cancers as a potential therapeutic approach in oncology. …

Evaluation Of Financial Risk Protection Provided By Private Health Insurance In Malaysia, Ng Rui Jie

Student Works (2020-2029)

Private health insurance (PHI) has emerged as an alternative health financing option to public health financing, with the goal of achieving and maintaining universal health coverage. Despite its growing prominence, there is ongoing debate about the extent to which PHI contributes to financial risk protection. In Malaysia, the prevalence of PHI coverage has increased due to factors such as an expanding affluent demographic, government encouragement, and challenges in public healthcare delivery. However, there have been very limited studies assessing the financial risk protection provided by PHI in Malaysia, making this a critical gap that this research aims to address. To …

Effectiveness And User Experience Of Nose And Throat Swabbing Techniques For Sars-Cov-2 Detection: Results From The Uk Covid-19 National Testing Programme, Matthias E Futschik, Raghavendran Kulasegaran-Shylini, Edward Blandford, Sean Harper, David Chapman, Elena Turek, Somya Agrawal, Valerie Phillips, Hannah Fordham, Lee Chan, Mike Kidd, Andrew Dodgson, Paul E Klapper, Malur Sudhanva, Richard Vipond, Susan Hopkins, Tim Peto, Sarah Tunkel, Tom Fowler

School of Biomedical Sciences

BACKGROUND: The UK's National Health Service Test and Trace (NHSTT) program aimed to provide the most effective and accessible SARS-CoV-2 testing approach possible. Early user feedback indicated that there were accessibility issues associated with throat swabbing. We report the results of service evaluations performed by NHSTT to assess the effectiveness and user acceptance of swabbing approaches, as well as qualitative findings of user experiences from research reports, surveys, and incident reports. Our intent is to present and summarize our findings about the application of alternative swabbing approaches during the COVID-19 pandemic in the UK.

METHODS: From May 2020 to December …

Sexual Stigma And Self-Actualization Of Persons With Disabilities, Yoga Budhi Santoso, Sunardi Tukimin, Endang Rochyadi, Imas Diana Aprilia, Juhanaini Juhanaini, Setyo Wahyu Wibowo, Ana Fatimatuzzahra, Prinanda Gustarina Ridwan, Zulfa Rahma, Ranti Novianti

Journal of ICSAR

This study aims to examine the stigma experienced by persons with disabilities, focusing on physical and sexual stigma and its relationship with self-actualization. Using a qualitative approach, the study involved 11 individuals with disabilities aged 20–31 years from various regions in Indonesia. Data were collected through questionnaires addressing sources and forms of stigma, as well as participants’ perceptions of their ability to achieve self-actualization, particularly in romantic and sexual relationships. Findings indicate that more than half of the respondents experienced stigma related to their physical condition, especially from family and neighborhood environments. Sexual stigma was less prevalent, with only a …

Empowering Parents Through Social-Emotional Learning: A Case Study Of Mindhaven School's Parent Education Program, Nilda B. Delgado, Genevieve Q. Collantes, Jan Jade N Tabasa, Diana Grace S Ariz, Mary Grace A Educado, Jovel Ann R Beramo, Frank S Emboltura

Journal of ICSAR

Transforming parental engagement into parental empowerment is essential for systemic transformation in school programs (Winthrop, 2020). MindHaven School, with a 30-year legacy of promoting parent empowerment, has effectively turned challenges, such as the COVID-19 pandemic, into opportunities to advance its mission. Through its "Every Home a School, Every Parent a Teacher" Learning Model, MindHaven's Parent Education Program (PEP) has emerged as a crucial initiative. During the pandemic, parents transitioned from supporters to direct implementers of their children’s education, attending 25-35 two-hour virtual training sessions per school year, compared to the previous 15-25 face-to-face sessions. These PEP sessions have been vital …

Challenges And Opportunities In Implementing The Teaching Factory Model In Special Needs Schools: Alternative Work Readiness For Students With Disabilities, Imas Diana Aprilia, Iding Tarsidi, Cece Rahmat, Tati Hernawati

Journal of ICSAR

The intense job competition and the low absorption rate of special needs school graduates in the business and industrial sectors are allegedly due to the ineffective implementation of the link-and-match concept. This study aims to analyze the challenges and opportunities faced by special needs schools in preparing students for the workforce through the Teaching Factory (TEFA) model. Using a descriptive qualitative method, data were collected from two principals and six vocational skills teachers through interviews, observations, and document analysis. The results indicate that teacher competence in mastering vocational skills remains low, the curriculum oriented toward Competency-Based Training (CBT) and Production-Based …

Zongertinib (Bi 1810631), An Irreversible Her2 Tki, Spares Egfr Signaling And Improves Therapeutic Response In Preclinical Models And Patients With Her2-Driven Cancers, Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, Yukina Shirai, Masachika Ikegami, Sylvia Tilandyová, Dirk Scharn, Mark A Pearson, Johannes Popow, Anna C Obenauf, Noboru Yamamoto, Shunsuke Kondo, Frans L Opdam, Annemarie Bruining, Shinji Kohsaka, Norbert Kraut, John V Heymach, Flavio Solca, Ralph A Neumüller

Faculty, Staff and Student Publications

Mutations in ERBB2 (encoding HER2) occur in 2% to 4% of non-small cell lung cancer (NSCLC) and confer poor prognosis. ERBB-targeting tyrosine kinase inhibitors, approved for treating other HER2-dependent cancers, are ineffective in HER2-mutant NSCLC due to dose-limiting toxicities or suboptimal potency. We report the discovery of zongertinib (BI 1810631), a covalent HER2 inhibitor. Zongertinib potently and selectively blocks HER2, while sparing EGFR, and inhibits the growth of cells dependent on HER2 oncogenic driver events, including HER2-dependent human cancer cells resistant to trastuzumab deruxtecan. Zongertinib displays potent antitumor activity in HER2-dependent human NSCLC xenograft models and enhances the activities of …

Neutrophil Extracellular Traps Promote Pre-Metastatic Niche Formation In The Omentum By Expanding Innate-Like B Cells That Express Il-10, Wonjae Lee, Song Yi Ko, Hironari Akasaka, Melanie Weigert, Ernst Lengyel, Honami Naora

Faculty, Staff and Student Publications

Disseminated cancer cells in the peritoneal fluid often colonize omental fat-associated lymphoid clusters but the mechanisms are unclear. Here, we identify that innate-like B cells accumulate in the omentum of mice and women with early-stage ovarian cancer concomitantly with the extrusion of chromatin fibers by neutrophils called neutrophil extracellular traps (NETs). Studies using genetically modified NET-deficient mice, pharmacologic inhibition of NETs, and adoptive B cell transfer show that NETs induce expression of the chemoattractant CXCL13 in the pre-metastatic omentum, stimulating recruitment of peritoneal innate-like B cells that in turn promote expansion of regulatory T cells and omental metastasis through producing …

Integrating Priorities At The Intersection Of Cancer And Neuroscience, William L Hwang, Ella N Perrault, Alexander Birbrair, Brandi J Mattson, David H Gutmann, Donald J Mabbott, Edna Cukierman, Elizabeth A Repasky, Erica K Sloan, Hui Zong, Ihsan Ekin Demir, Jami L Saloman, Jeremy C Borniger, Jian Hu, Jorg Dietrich, Joshua J Breunig, Kaan Çifcibaşı, Khalil Ali Ahmad Kasm, Manuel Valiente, Max Wintermark, Munjal M Acharya, Nicole N Scheff, Nisha J D'Silva, Paola D Vermeer, Richard J Wong, Sebastien Talbot, Shawn L Hervey-Jumper, Timothy C Wang, Yi Ye, Yuan Pan, Yuri L Bunimovich, Moran Amit

Faculty, Staff and Student Publications

Cancer neuroscience is a rapidly growing multidisciplinary field that conceptualizes tumors as tissues fully integrated into the nervous system. Recognizing the complexity and challenges in this field is of fundamental importance to achieving the goal of translational impact for cancer patients. Our commentary highlights key scientific priorities, optimal training settings, and roadblocks to translating scientific findings to the clinic in this emerging field, aiming to formulate a transformative and cohesive path forward.