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Full-Text Articles in Entire DC Network
Interprofessional Collaboration To Improve Discharge Planning, Erica L. Spalding
Interprofessional Collaboration To Improve Discharge Planning, Erica L. Spalding
Doctoral Projects
Historically, health care professionals collaborated solely with other professionals within the same discipline. However, evidence shows collaboration between all disciplines involved in patient care leads to improved patient outcomes. Interprofessional collaboration can reduce costs and improve patient care, yet is used inconsistently in health care systems. Interprofessional collaboration was not fully used on two medical-surgical units in a large health system in the Midwest, particularly during the discharge planning process. This project aimed to standardize rounds on two units as part of a larger initiative to standardize rounds across all units within the system. The clinical question to be answered …
Interprofessional Collaboration During Discharge Planning For A Large Midwestern Hospital, Sarah Shepler
Interprofessional Collaboration During Discharge Planning For A Large Midwestern Hospital, Sarah Shepler
Doctoral Projects
Introduction: Interprofessional collaboration (IPC) improves the quality of healthcare delivery. IPC enhances communication during discharge planning, through use of structured daily rounds to reduce readmissions, length of stay (LOS), cost, and mortality. A $240 billion reduction in cost could be achieved with IPC. The Joint Commission, Institute of Medicine, and World Health Organization emphasize use of IPC to reduce errors, improve patient outcomes, and refine transitions of care for patients.
Objectives: The goal of this project was to determine how IPC within structured daily rounds during discharge planning impacts patient LOS and staff satisfaction.
Methods: This quality improvement project was …
Forum, Volume 43, No. 1, Spring 2019, Florida Humanities Council, Jacki Levine
Forum, Volume 43, No. 1, Spring 2019, Florida Humanities Council, Jacki Levine
FORUM: The Magazine of Florida Humanities
Contents: Finding Shared Values -- Igniting a Spark in the Center of It All -- Humanities Today -- This Florida Life: A Life of Firsts -- A Teacher to Remember: Awakening the Reader Within -- Insider's Florida: A Tale of Two Cities -- State of Inspiration: Finding Home -- Florida by Design: Embracing the Sea and Sky -- Artful Revivals -- The Sweetness of Memory -- My Florida Journey: A New Life in America -- Why We Tell These Stories -- State of Wonder: Rounding the Curve
Improving Nursing Students’ Attitudes And Beliefs About Transgender Clients Through The Use Of A Simulated Clinical Experience, J. Alex Thompson Msn, M.Ed., Rn, Cne
Improving Nursing Students’ Attitudes And Beliefs About Transgender Clients Through The Use Of A Simulated Clinical Experience, J. Alex Thompson Msn, M.Ed., Rn, Cne
Doctor of Nursing Practice Projects
Background: Negative healthcare experiences may lead to poor health outcomes for transgender individuals, but nursing curricula give little attention to transgender healthcare. This study engaged nursing students in a simulated clinical experience (SCE) which featured a young adult transgender male in an acute care setting to determine whether participation would have a significant impact on student nurses’ attitudes and beliefs about transgender individuals.
Methods: The convergent parallel mixed-methods design used a one group pretest-posttest and a post-case debriefing interview to examine undergraduate nursing student attitudes and beliefs toward transgender individuals. Participants (N=27) reported their feelings via the Transgender Attitudes and …
Self-Efficacy In Emerging Nurse Leaders: The Effects Of A Virtual Community Of Practice On Nurse Educators In A New Practice Role, Kevin Daugherty Hook Msn, Ma, Ms, Agpcnp-Bc, Crnp
Self-Efficacy In Emerging Nurse Leaders: The Effects Of A Virtual Community Of Practice On Nurse Educators In A New Practice Role, Kevin Daugherty Hook Msn, Ma, Ms, Agpcnp-Bc, Crnp
Doctor of Nursing Practice Projects
Background: Clinical nurse educators in long-term and skilled nursing facilities have an opportunity to exercise new leadership skills in bridging the gap between education and practice.
Objective: To assess the effects of a virtual Community of Practice (CoP) on the self-efficacy of clinical nurse educators who work in newly developing leadership roles in a large long-term and skilled nursing organization operating in multiple sites across the United States.
Methodology: The exploratory pilot study used a one group pre-test/posttest method. A convenience sample was used to enroll participants with newly created roles in clinical education. The Leader Efficacy Questionnaire (LEQ) was …
A Comparison Of The United States And Costa Rican Health Care Systems And Their Influence On Immigrant Women's Maternal And Child Health Outcomes, Tamera R. Sullivan
A Comparison Of The United States And Costa Rican Health Care Systems And Their Influence On Immigrant Women's Maternal And Child Health Outcomes, Tamera R. Sullivan
Senior Theses
Health is a fundamental right for all humans, and every nation has a unique system for health care delivery. While the United States and Costa Rica follow two different welfare state models, there is still value in comparing the two countries. This project was inspired by my public health-based study abroad experience in Costa Rica in May 2018, which sparked a desire to learn more about the structures that form the health care system of each country. The United States has a more privatized and fragmented health care system, while Costa Rica has a public, universal health care system. Although …
The Effects Of Marine Natural Products On The Microenvironment Of Pancreatic Cancer, Whitney D. Davis, Esther Guzman
The Effects Of Marine Natural Products On The Microenvironment Of Pancreatic Cancer, Whitney D. Davis, Esther Guzman
Honors Theses
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States, with that number increasing each year. New drugs need to be developed to treat this disease. One source of new drugs is marine natural products. Two compounds—HB-131 and HB-018—were tested for potential anti-cancer properties. Pancreatic cancer cells were exposed to these compounds for six hours and the conditioned media from this treatment was used to further our understanding of the effects of these compounds. A western blot was used to determine matrix metalloproteinase (MMP) expression, while a zymogram was used to determine MMP activity. A sandwich …
2019-2020 Summer Bulletin, University Of Mississippi Medical Center
2019-2020 Summer Bulletin, University Of Mississippi Medical Center
Bulletins/Catalogs
2019-2020 Summer Bulletin
Menakar Keberlanjutan Program Kube: Peluang Dan Tantanganprogram Kube Dalam Pemberdayaan Masyarakat Miskin Perkotaandi Kelurahan Keparakan, Kecamatan Mergangsan, Kotayogyakarta, Laras Aprilianti, Eka Zuni Lusi Astuti
Menakar Keberlanjutan Program Kube: Peluang Dan Tantanganprogram Kube Dalam Pemberdayaan Masyarakat Miskin Perkotaandi Kelurahan Keparakan, Kecamatan Mergangsan, Kotayogyakarta, Laras Aprilianti, Eka Zuni Lusi Astuti
Jurnal Ilmu Kesejahteraan Sosial
KUBE is one of the poverty alleviation programs under the Directorate of Social Empowerment and Poverty Reduction, Ministry of Social Affairs. This program aims to empower the poor groups through the financial assistance to support productivity in economy. KUBE in Keparakan Village, Mergangsan, Yogyakarta City is one of the KUBE in DIY Province which is the best KUBE candidate in DIY. Ironically, within 3 years implementation of the KUBE Program, from 6 KUBE, 4 KUBE sustainable and the other 2 was discontinued. This paper seeks to examine what are the supporting and inhibiting factors for the implementation of sustainability KUBE …
Badan Usaha Milik Desa (Bumdes) Ijen Lestari Sebagai Inovasipelayanan Publik Untuk Mendukung Pengembangan Ekonomilokal Melalui Community Based Tourism, Harod Rahmad Novandi, Isbandi Rukminto Adi
Badan Usaha Milik Desa (Bumdes) Ijen Lestari Sebagai Inovasipelayanan Publik Untuk Mendukung Pengembangan Ekonomilokal Melalui Community Based Tourism, Harod Rahmad Novandi, Isbandi Rukminto Adi
Jurnal Ilmu Kesejahteraan Sosial
The proportion of rural poverty is always higher than urban poverty in Indonesia. Poverty reduction programs, especially in rural areas, should put the community as the priority subject in each program. Banyuwangi Regency in East Java Province is one of the best example in poverty reduction program. Banyuwangi succeed to reduce its poverty rate significantly from tourism sector. This tourism increases income per capita of Banyuwangi from year to year. The poverty reduction in Banyuwangi is influenced by smart kampung and local economic development through a community-based tourism. (CBT) and Initiating local industry.Based on observation and in depth interview, Village-Owned …
Dampak Bumdes Terhadap Kesejahteraan Masyarakat Didesa Aik Batu Buding, Kabupaten Belitung, Provinsi Bangkabelitung, Muhammad Fajar Nandra Caya, Ety Rahayu
Dampak Bumdes Terhadap Kesejahteraan Masyarakat Didesa Aik Batu Buding, Kabupaten Belitung, Provinsi Bangkabelitung, Muhammad Fajar Nandra Caya, Ety Rahayu
Jurnal Ilmu Kesejahteraan Sosial
Village development is a priority in national development, because it is closely related to the third point of the President's Nawacita which states that it is developing Indonesia from the periphery by strengthening regions and villages within the framework of a unitary state. This study aims to describe the impact of BUMDES on the welfare of rural communities. BUMDES is one of the programs to strengthen the role of the region. village aik batu buding, Belitung Districts, Bangka Belitung Islands Province has become one of the best BUMDES in the Province in 2016, because it is interesting to see the …
Aksi Sosial Komunitas Nelayan Cantrang Terhadapkebijakan Larangan Penggunaan Alat Penangkapan Ikan, Aulia Siti Ambarwati, Isbandi Rukminto Adi
Aksi Sosial Komunitas Nelayan Cantrang Terhadapkebijakan Larangan Penggunaan Alat Penangkapan Ikan, Aulia Siti Ambarwati, Isbandi Rukminto Adi
Jurnal Ilmu Kesejahteraan Sosial
This research describes the existence of interventions at the community level through social action / community action carried out by the cantrang fishing community in Tasikagung Village, Rembang Regency. This action is an effort by the cantrang fishing community to fight for their welfare after the issuance of a policy on the prohibition on the use of cantrang type fishing gear through the Minister of Maritime Affairs and Fisheries Regulation of the Republic of Indonesia. This research is a study that uses a qualitative approach, with the type of research descriptive. The results of this study show that the change …
Technology For Behavioral Change In Rural Older Adults With Obesity, John A. Batsis, John A. Naslund, Alexandra B. Zagaria, David Kotz, Rachel Dokko, Stephen J. Bartels, Elizabeth Carpenter-Song
Technology For Behavioral Change In Rural Older Adults With Obesity, John A. Batsis, John A. Naslund, Alexandra B. Zagaria, David Kotz, Rachel Dokko, Stephen J. Bartels, Elizabeth Carpenter-Song
Dartmouth Scholarship
Background: Mobile health (mHealth) technologies comprise a multidisciplinary treatment strategy providing potential solutions for overcoming challenges of successfully delivering health promotion interventions in rural areas. We evaluated the potential of using technology in a high-risk population.
Methods: We conducted a convergent, parallel mixed-methods study using semi-structured interviews, focus groups, and self-reported questionnaires, using purposive sampling of 29 older adults, 4 community leaders and 7 clinicians in a rural setting. We developed codes informed by thematic analysis and assessed the quantitative data using descriptive statistics.
Results: All groups expressed that mHealth could improve health behaviors. Older adults were optimistic that mHealth …
Vietnamese Family Caregivers’ Adjustment Process To Their Caregiving Roles For Family Members With Dementia, Trang Nguyen
Vietnamese Family Caregivers’ Adjustment Process To Their Caregiving Roles For Family Members With Dementia, Trang Nguyen
Theses and Dissertations
This study explores the psychological process that Vietnamese family members go through to adjust to the caregiving role for their relatives with dementia. Adopting constructivist grounded theory, 30 face-to-face, semi-structured interviews, including 10 follow-up interviews, were conducted with 20 Vietnamese primary family caregivers of relatives with dementia from the National Geriatric Hospital in Vietnam. The study results reveal that Vietnamese family caregivers held limited understanding of dementia. They used a mixed explanatory model, combining both folk (e.g., dementia as normal aging) and biomedical approaches (e.g., dementia as a brain-related disease) to explain causes of dementia. Family cohesion and responsibility are …
What Happens Here Stays Here? Associations Between Choices During The Twenties And Flourishing Or Floundering During The Thirties, Melanie Lynn Lott
What Happens Here Stays Here? Associations Between Choices During The Twenties And Flourishing Or Floundering During The Thirties, Melanie Lynn Lott
Theses and Dissertations
Life course theory suggests that an individual’s development is influenced by many factors such as one’s past choices and environment. The twenties are a period of great autonomy for many young people with opportunities to engage in choices with lasting consequences, both positive (e.g., furthering education, volunteering) and negative (e.g., crime, risky sexual behavior, heavy video game use). The current study explored the relationship between behaviors during one’s twenties and indices of adjustment (i.e., life satisfaction, relationship satisfaction, and hope) and maladjustment (i.e., poor emotional health and regret) in one’s thirties. Additionally, as factors such as income and biological sex …
Oscillations In Neural Drive And Age-Related Reductions In Force Steadiness With A Cognitive Challenge, Hugo M. Pereira, Bonnie A. Schlinder-Delap Mrs., Kevin G. Keenan, Francesco Negro, Dario Farina, Allison S. Hyngstrom, Kristy A. Nielson, Sandra K. Hunter
Oscillations In Neural Drive And Age-Related Reductions In Force Steadiness With A Cognitive Challenge, Hugo M. Pereira, Bonnie A. Schlinder-Delap Mrs., Kevin G. Keenan, Francesco Negro, Dario Farina, Allison S. Hyngstrom, Kristy A. Nielson, Sandra K. Hunter
Exercise Science Faculty Research and Publications
A cognitive challenge when imposed during a low-force isometric contraction will exacerbate sex- and age-related decreases in force steadiness, but the mechanism is not known. We determined the role of oscillations in the common synaptic input to motor units on force steadiness during a muscle contraction with a concurrent cognitive challenge. Forty-nine young adults (19–30 yr; 25 women, 24 men) and 36 old adults (60–85 yr; 19 women, 17 men) performed a cognitive challenge (counting backward by 13) during an isometric elbow flexion task at 5% of maximal voluntary contraction. Single-motor units were decomposed from high-density surface EMG recordings. For …
A Collaborative Case Management Model In An End Stage Renal Disease Patient Population, Linda Q. Everett
A Collaborative Case Management Model In An End Stage Renal Disease Patient Population, Linda Q. Everett
Dissertations
The purpose of this pilot study was to examine the effectiveness of a collaborative case management (CCM) model on an end stage renal disease (ESRD) patient population. The study attempted to confront some of the conceptual and methodological issues surrounding the study of case management. Those issues included: absence of a theoretical framework; the omission of operational definitions of case management; lack of clear specification and measurement of sample selection criteria; the frequent use of weak pre-post designs; and the use of unstandardized instruments. The following strategies to address these issues were presented: a theoretical framework was developed in which …
Cross-Day Influences Between Couple Closeness And Coparenting Support Among New Parents., Yunying Le, Steffany J Fredman, Brandon T. Mcdaniel Phd, Jean-Philippe Laurenceau, Mark E Feinberg
Cross-Day Influences Between Couple Closeness And Coparenting Support Among New Parents., Yunying Le, Steffany J Fredman, Brandon T. Mcdaniel Phd, Jean-Philippe Laurenceau, Mark E Feinberg
Health Services and Informatics Research
The couple and coparenting relationships are demonstrated to be prospectively and bidirectionally associated over months to years during the early parenting years. However, little is known about these associations at the daily level within the first year of parenthood, when coparenting first emerges. The goal of the current study was to examine the association between couples' daily feelings of relationship closeness and coparenting support in first-time parents and determine directionality of these effects using a dyadic daily diary design. At 10 months postpartum, heterosexual couples (
The Relationship Between Identity Dimensions, Gender Conformity, And Satisfaction With Life, Alexandria Colburn
The Relationship Between Identity Dimensions, Gender Conformity, And Satisfaction With Life, Alexandria Colburn
Master's Theses (2009 -)
There is a large body of evidence indicating physical and mental health disparities among marginalized populations. The purpose of this study was to examine the relationship between identity dimensions, gender conformity, and well-being. I anticipated that identification with a marginalized identity group would predict poorer satisfaction with life, compared to identification with a privileged group. In addition, I investigated the role of gender conformity as a possible interaction variable in the relationship between identity factors (assigned sex, age, race, ethnicity, and sexual orientation) and outcomes of satisfaction with life. A hierarchical multiple regression was used to investigate these hypotheses. Results …
Technical Processing Of University Library: A Theoretical Study, Rajib Kalita
Technical Processing Of University Library: A Theoretical Study, Rajib Kalita
Library Philosophy and Practice (e-journal)
Technical services operations comprise of ordering, claiming and receipt of materials, cataloging and classification of materials; and serials control. Beside these, other technical services operations contain circulation, documents, foreign language and special collections, and bibliographic instruction in technical services areas. This leads me to believe that the distinction between technical services and public or reader services in individual libraries is based on custom and tradition arising out of incidental circumstances, rather than on fundamental principle. In this article, I tried to provide some basic aspect regarding technical processing which help in maintaining the library bitterly. In this article, I include …
14th Annual Research In The Capitol [Program], April 1, 2019, University Of Northern Iowa. University Honors Program., Iowa State University. Honors Program., University Of Iowa. Honors Program.
14th Annual Research In The Capitol [Program], April 1, 2019, University Of Northern Iowa. University Honors Program., Iowa State University. Honors Program., University Of Iowa. Honors Program.
Research in the Capitol Programs
Program of research presentations given at the Capitol by students from the University of Northern Iowa, Iowa State University, and the University of Iowa.
Is Technology The Key To Prevention Of Falls Among The Elderly In Rapidly Aging Societies? A Case Study Of Kunming, China, Phoebe Kiburi
Is Technology The Key To Prevention Of Falls Among The Elderly In Rapidly Aging Societies? A Case Study Of Kunming, China, Phoebe Kiburi
Independent Study Project (ISP) Collection
As the aging society rapidly becomes more dominant in the world, there is a pressing need for different stakeholders to tend to the needs of the aging sufficiently. This is crucial in ensuring the robustness of the healthcare system as a whole; given that it can only be as strong as its weakest link. This study focuses on one of the areas of need of the ageing society: fall prevention.
Numerous studies have been done on interventions by the government, private entities, elderly people and their caregivers to prevent occurrence and recurrence of falls. However, most of these have been …
Education On Burnout And Self-Care At The University Of Southern Maine School Of Social Work: A Case Study, Noelani S. Hansen Msw
Education On Burnout And Self-Care At The University Of Southern Maine School Of Social Work: A Case Study, Noelani S. Hansen Msw
All Student Scholarship
Social work practitioners can experience symptoms of burnout at high rates, and sometimes are not able to effectively engage in self-care to combat these symptoms. For social work students, learning the signs of burnout and how to practice self-care are crucial tools. However, there is scant information in the literature on burnout and selfcare in social work curricula. This case study looks at the education on burnout and selfcare in the University of Southern Maine (USM) School of Social Work. Social work professors were interviewed on how they teach about burnout and self-care, and undergraduate and graduate students were interviewed …
Glycated Serum Protein Genetics And Pleiotropy With Cardiometabolic Risk Factors, Matthew P. Johnson, Ryan Keyho, Nicholas B. Blackburn, Sandra Laston, Satish Kumar, Juan M. Peralta, Suman S. Thapa, Bradford Towne, Janardan Subedi, John Blangero, Sarah Williams-Blangero
Glycated Serum Protein Genetics And Pleiotropy With Cardiometabolic Risk Factors, Matthew P. Johnson, Ryan Keyho, Nicholas B. Blackburn, Sandra Laston, Satish Kumar, Juan M. Peralta, Suman S. Thapa, Bradford Towne, Janardan Subedi, John Blangero, Sarah Williams-Blangero
School of Medicine Publications
Measurements of fasting glucose (FG) or glycated hemoglobin A1c (HbA1c) are two clinically approved approaches commonly used to determine glycemia, both of which are influenced by genetic factors. Obtaining accurate measurements of FG or HbA1c is not without its challenges, though. Measuring glycated serum protein (GSP) offers an alternative approach for assessing glycemia. The aim of this study was to estimate the heritability of GSP and GSP expressed as a percentage of total serum albumin (%GA) using a variance component approach and localize genomic regions (QTLs) that harbor genes likely to influence GSP and %GA trait variation in a large …
A Qtl On Chromosome 3q23 Influences Processing Speed In Humans, Emma E. M. Knowles, Samuel R. Mathias, Josephine Mollon, Amanda Rodrigue, Marinka M. G. Koenis, Thomas D. Dyer, Harald H. H. Goring, Joanne E. Curran, Rene L. Olvera, Ravindranath Duggirala, Laura Almasy, John Blangero, David C. Glahn
A Qtl On Chromosome 3q23 Influences Processing Speed In Humans, Emma E. M. Knowles, Samuel R. Mathias, Josephine Mollon, Amanda Rodrigue, Marinka M. G. Koenis, Thomas D. Dyer, Harald H. H. Goring, Joanne E. Curran, Rene L. Olvera, Ravindranath Duggirala, Laura Almasy, John Blangero, David C. Glahn
School of Medicine Publications
Processing speed is a psychological construct that refers to the speed with which an individual can perform any cognitive operation. Processing speed correlates strongly with general cognitive ability, declines sharply with age, and is impaired across a number of neurological and psychiatric disorders. Thus, identifying genes that influence processing speed will likely improve understanding of the genetics of intelligence, biological aging, and the etiologies of numerous disorders. Previous genetics studies of processing speed have relied on simple phenotypes (e.g., mean reaction time) derived from single tasks. This strategy assumes, erroneously, that processing speed is a unitary construct. In the present …
Robots Instead Of Immigrants: The Positive Feedback Of Japanese Migration Policy On Social Isolation And Communication Problems, Pál Koudela
Asia-Pacific Social Science Review
Demographic decline in contemporary Japan already leads to labor shortages, and there is still no existing fertility policy to stop the shrinking population. As an alternative, immigration policy could serve for replacement. However, the Japanese government opposes it mainly because of their idea of cultural homogeneity. Such thought has its historical and cultural background in the confrontation of centuries-long isolation and modern ethnic nationalism in the Meiji period. The recent plan of the Japanese leadership is to increase the role of robotics in affected professions such as caregiving. At this point, the social role of robots is going through a …
Tobacco Smoking And Dementia In A Kentucky Cohort: A Competing Risk Analysis, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Gregory E. Cooper, David W. Fardo, Frederick A. Schmitt, Richard J. Kryscio
Tobacco Smoking And Dementia In A Kentucky Cohort: A Competing Risk Analysis, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Gregory E. Cooper, David W. Fardo, Frederick A. Schmitt, Richard J. Kryscio
Epidemiology and Environmental Health Faculty Publications
Tobacco smoking was examined as a risk for dementia and neuropathological burden in 531 initially cognitively normal older adults followed longitudinally at the University of Kentucky’s Alzheimer’s Disease Center. The cohort was followed for an average of 11.5 years; 111 (20.9%) participants were diagnosed with dementia, while 242 (45.6%) died without dementia. At baseline, 49 (9.2%) participants reported current smoking (median pack-years = 47.3) and 231 (43.5%) former smoking (median pack-years = 24.5). The hazard ratio (HR) for dementia for former smokers versus never smokers based on the Cox model was 1.64 (95% CI: 1.09, 2.46), while the HR for …
A Changed Reality: Experience Of An Acceptance And Commitment Therapy (Act) Group After Stroke, Rebecca Large, Victoria Samuel, Reg Morris
A Changed Reality: Experience Of An Acceptance And Commitment Therapy (Act) Group After Stroke, Rebecca Large, Victoria Samuel, Reg Morris
School of Psychology
No abstract provided.
Glycine Supplementation Extends Lifespan Of Male And Female Mice, Richard A. Miller, David E. Harrison, C. Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G. Ryazanov, Jessica Snyder, Timothy M. Stearns, Douglas E. Vaughan, Randy Strong
Glycine Supplementation Extends Lifespan Of Male And Female Mice, Richard A. Miller, David E. Harrison, C. Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G. Ryazanov, Jessica Snyder, Timothy M. Stearns, Douglas E. Vaughan, Randy Strong
Publications and Research
Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%–6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively. Glycinesupplemented females were lighter than controls, but there was no effect on weight in males. End‐of‐life necropsies suggested that glycine‐treated mice were less likely than controls to die of pulmonary adenocarcinoma (p = 0.03). Of the 40 varieties of incidental pathology evaluated in these mice, none were increased to a significant degree by the glycine‐supplemented diet. In parallel analyses of the same cohort, we found no benefits from TM5441 (an inhibitor of PAI‐1, the primary inhibitor of tissue and urokinase plasminogen activators), inulin (a source of soluble fiber), or aspirin at either of two doses. Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late‐life diseases.
Health Care Providers: Please Listen, Jasmin Tahmaseb-Mcconatha
Health Care Providers: Please Listen, Jasmin Tahmaseb-Mcconatha
Psychology Faculty Publications
Remind providers that you can contribute to your health care decisions.