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Safety, Feasibility And Initial Efficacy Of An App-Facilitated Telerehabilitation (After) Programme For Covid-19 Survivors: A Pilot Randomised Study, Jacob J. Capin, Sarah Jolley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha Mawhinney, Amy Nordon-Craft, Michelle R. Rauzi, Sheryl Flynn, Jennifer Stevens-Lapsley, Kristine M. Erlandson Jan 2022

Safety, Feasibility And Initial Efficacy Of An App-Facilitated Telerehabilitation (After) Programme For Covid-19 Survivors: A Pilot Randomised Study, Jacob J. Capin, Sarah Jolley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha Mawhinney, Amy Nordon-Craft, Michelle R. Rauzi, Sheryl Flynn, Jennifer Stevens-Lapsley, Kristine M. Erlandson

Physical Therapy Faculty Research and Publications

Objectives Determine the safety, feasibility and initial efficacy of a multicomponent telerehabilitation programme for COVID-19 survivors.

Design Pilot randomised feasibility study.

Setting In-home telerehabilitation.

Participants 44 participants (21 female, mean age 52 years) discharged home following hospitalisation with COVID-19 (with and without intensive care unit (ICU) stay).

Interventions Participants were block randomised 2:1 to receive 12 individual biobehaviourally informed, app-facilitated, multicomponent telerehabilitation sessions with a licenced physical therapist (n=29) or to a control group (n=15) consisting of education on exercise and COVID-19 recovery trajectory, physical activity and vitals monitoring, and weekly check-ins with study staff. Interventions were 100% remote and …


Driving Performance In Older Adults: Current Measures, Findings, And Implications For Roadway Safety, Robert Toups, Theresa J Chirles, Johnathon P Ehsani, Jeffrey P Michael, John P K Bernstein, Matthew Calamia, Thomas D Parsons, David B Carr, Jeffrey N Keller Jan 2022

Driving Performance In Older Adults: Current Measures, Findings, And Implications For Roadway Safety, Robert Toups, Theresa J Chirles, Johnathon P Ehsani, Jeffrey P Michael, John P K Bernstein, Matthew Calamia, Thomas D Parsons, David B Carr, Jeffrey N Keller

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Over 10,000 people a day turn 65 in the United States. For many older adults, driving represents an essential component of independence and is one of the most important factors in overall mobility. Recent survey studies in older adults suggest that up to 60% of older adult drivers with mild cognitive impairment, and up to 30% with dementia, continue to drive. The purpose of this review is to provide a comprehensive and detailed resource on the topics of cognition and driving for clinicians, researchers, and policymakers working on efforts related to older adult drivers.

RESEARCH DESIGN AND …


Relationships Between Handgrip Strength Asymmetry And Multimorbidity In Canadian Adults Aged 40 Years And Older: Results From The Canadian Health Measures Survey, Morgan Ann Flann Jan 2022

Relationships Between Handgrip Strength Asymmetry And Multimorbidity In Canadian Adults Aged 40 Years And Older: Results From The Canadian Health Measures Survey, Morgan Ann Flann

Theses and Dissertations

Background: Hand-grip strength (HGS) is a convenient, valid, and reliable measure of overall muscle strength that is significantly related to current and future health. HGS asymmetry is an additional aspect of muscle function that can also be measured using handheld dynamometry. The aim of this study was to examine associations between HGS asymmetry and multimorbidity in a nationally representative sample of Canadian adults aged 40 years or older. Methods: A secondary analysis of cross-sectional data was performed on adults aged 40-79 years from six cycles (2007- 2017) of the Canadian Health Measures Survey (CHMS). HGS was assessed using handheld dynamometry, …


Preferences Of Newly Qualified Healthcare Professionals For Working With People With Dementia: A Qualitative Study, M Hebditch, S Banerjee, J Wright, S Daley Jan 2022

Preferences Of Newly Qualified Healthcare Professionals For Working With People With Dementia: A Qualitative Study, M Hebditch, S Banerjee, J Wright, S Daley

School of Health Professions

Background there is little research on preferences in students and newly qualified healthcare professionals for working with people with dementia. Understanding the development of these preferences can help inform strategies to increase workforce capacity in response to current suboptimal dementia care and the increasing numbers of people with dementia. Objective to explore the factors that influence career preferences in relation to working with people with dementia. Specifically, to understand how these factors relate to early career doctors’ and nurses’ preferences and how they influence decisions and perspectives on their careers. Methods qualitative in-depth interviews were conducted with 27 newly qualified …


Long‐Term Effects Of Artificial Nighttime Lighting And Trophic Complexity On Plant Biomass And Foliar Carbon And Nitrogen In A Grassland Community, Vinka Anic, Kevin J. Gaston, Thomas W. Davies, Jonathan Bennie Jan 2022

Long‐Term Effects Of Artificial Nighttime Lighting And Trophic Complexity On Plant Biomass And Foliar Carbon And Nitrogen In A Grassland Community, Vinka Anic, Kevin J. Gaston, Thomas W. Davies, Jonathan Bennie

School of Biological and Marine Sciences

No abstract provided.


Weakly Activated Core Neuroinflammation Pathways Were Identified As A Central Signaling Mechanism Contributing To The Chronic Neurodegeneration In Alzheimer's Disease, Fuhai Li, Abdallah M Eteleeb, William Buchser, Christopher Sohn, Guoqiao Wang, Chengjie Xiong, Philip R Payne, Eric Mcdade, Celeste M Karch, Oscar Harari, Carlos Cruchaga Jan 2022

Weakly Activated Core Neuroinflammation Pathways Were Identified As A Central Signaling Mechanism Contributing To The Chronic Neurodegeneration In Alzheimer's Disease, Fuhai Li, Abdallah M Eteleeb, William Buchser, Christopher Sohn, Guoqiao Wang, Chengjie Xiong, Philip R Payne, Eric Mcdade, Celeste M Karch, Oscar Harari, Carlos Cruchaga

2020-Current year OA Pubs

OBJECTIVES: Neuroinflammation signaling has been identified as an important hallmark of Alzheimer's disease (AD) in addition to amyloid β plaques (Aβ) and neurofibrillary tangles (NFTs). However, the molecular mechanisms and biological processes of neuroinflammation remain unclear and have not well delineated using transcriptomics data available. Our objectives are to uncover the core neuroinflammation signaling pathways in AD using integrative network analysis on the transcriptomics data.

MATERIALS AND METHODS: From a novel perspective, i.e., investigating weakly activated molecular signals (rather than the strongly activated molecular signals), we developed integrative and systems biology network analysis to uncover potential core neuroinflammation signaling targets …


Undergraduate Catalog, Georgia Southern University Jan 2022

Undergraduate Catalog, Georgia Southern University

Undergraduate & Graduate Catalogs

No abstract provided.


Development And Implementation Of An Electronic Clinical Dementia Rating And Financial Capacity Instrument-Short Form, Taylor Howell, John C Morris, Krista L Moulder, Connie Mayo, Maria Carroll, Yan Li, Et Al Jan 2022

Development And Implementation Of An Electronic Clinical Dementia Rating And Financial Capacity Instrument-Short Form, Taylor Howell, John C Morris, Krista L Moulder, Connie Mayo, Maria Carroll, Yan Li, Et Al

2020-Current year OA Pubs

Introduction: To address the need for remote assessments of cognitive decline and dementia, we developed and administered electronic versions of the Clinical Dementia Rating (CDR®) and the Financial Capacity Instrument-Short Form (FCI-SF) (F-CAP

Methods: The CDR and FCI-SF were adapted for remote, unsupervised, online use based on item response analysis of the standard instruments. Participants completed the eCDR and eFCI first in clinic, and then at home within 2 weeks.

Results: Of the 243 enrolled participants, 179 (73%) cognitively unimpaired (CU), 50 (21%) with mild cognitive impairment (MCI) or dementia, and 14 (6%) with an unknown diagnosis, 84% and 85% …


Associations Of Polymorphisms In The Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis, Tessa Schillemans, Sharon Cresci, Et Al Jan 2022

Associations Of Polymorphisms In The Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis, Tessa Schillemans, Sharon Cresci, Et Al

2020-Current year OA Pubs

No abstract provided.


Religion And Meaning: Its Moderating Effects On Stressful Life Events And Mental Health, Kalie B. Chambless Jan 2022

Religion And Meaning: Its Moderating Effects On Stressful Life Events And Mental Health, Kalie B. Chambless

College of Graduate Studies: Theses & Dissertations

The present study was designed to examine the relationship among religion, mental health, stressful life events, and people’s sense of meaning and purpose in life using data from the 2017 Baylor Religion Survey (BRS), a publicly available dataset. This survey obtained data from a nationwide study of 1,501 United States adults, 1,402 of whom are included in the current analyses. The first three hypotheses of this study were that (1) religion is positively associated with meaning to an individual’s life, that (2) meaning is positively associated with mental health, and that (3) stress is negatively associated with mental health. Finally, …


Perspectives On Wider Integration Of The Health-Assistive Smart Home, Gordana Dermody, Jenna Mikus, Davina Porock, Dov Sugarman, Naeem K. Janjua, Christopher How, Roschelle Fritz Jan 2022

Perspectives On Wider Integration Of The Health-Assistive Smart Home, Gordana Dermody, Jenna Mikus, Davina Porock, Dov Sugarman, Naeem K. Janjua, Christopher How, Roschelle Fritz

Research outputs 2022 to 2026

Most older adults desire to be as independent as possible and remain living in their ancestral home as they age. Aging-in-place maximizes the independence of older adults, enhancing their wellbeing and quality of life while decreasing the financial burden of residential care costs. However, due to chronic disease, multimorbidity, and age-related changes, appropriate conditions are required to make aging-in-place possible. Remote monitoring with smart home technologies could provide the infrastructure that enables older adults to remain living independently in their own homes safely. The health-assistive smart home shows great promise, but there are challenges to integrating smart homes on a …


Exploring Issues Of Resilience And Technology Use For Older People - A Scoping Review Protocol, Timothy J. Smith, Khui Hung Lee, Kan Yu, Leisa Armstrong, David M. Cook Jan 2022

Exploring Issues Of Resilience And Technology Use For Older People - A Scoping Review Protocol, Timothy J. Smith, Khui Hung Lee, Kan Yu, Leisa Armstrong, David M. Cook

Research outputs 2022 to 2026

The aim of this scoping review is to understand the extent of issues of resilience implied by the interactions of older people with financial, social, and health related technologies. Older people aged 60+, technology use or non-use, and issues of resilience studied over the last four years (2019-2022) demarcate the scope of this review. Key exclusion criteria are older adults living in long-term care facilities, nursing homes, care homes and hospital in-patients. It also excludes studies on the perspectives of older peoples’ clinicians. The review will be carried out according to the Joanna Briggs Institute (JBI) scoping review methodology. The …


The Nursing Care Of People With Class Iii Obesity In An Acute Care Setting: A Scoping Review, Bev Ewens, Vivien Kemp, Mandy (Amanda) Towell-Barnard, Lisa Whitehead Jan 2022

The Nursing Care Of People With Class Iii Obesity In An Acute Care Setting: A Scoping Review, Bev Ewens, Vivien Kemp, Mandy (Amanda) Towell-Barnard, Lisa Whitehead

Research outputs 2022 to 2026

Background

Patients with Class III obesity pose unique challenges to health care staff and organisations. Care requirements of this population are unique and require specialised equipment and knowledge to meet these needs, maintain the quality of care, as well as the safety of patients and staff.

Aim

To synthesise the evidence on the nursing care of Class III obese patients in acute care settings.

Methods

A scoping review informed by JBI. CINAHL Plus, Medline, Scopus, Proquest Central, Web of Science and Embase were searched for primary research articles about the nursing management of people classified as Class III obese in …


The Impact Of Skeletal Muscle Disuse On Distinct Echo Intensity Bands: A Retrospective Analysis, Zachary S. Logeson, Rob J. Maclennan, Gerard Kyle B. Abad, Johnathon M. Methven, Molly R. Gradl, Matheus D. Pinto, Ronei S. Pinto, Matt S. Stock Jan 2022

The Impact Of Skeletal Muscle Disuse On Distinct Echo Intensity Bands: A Retrospective Analysis, Zachary S. Logeson, Rob J. Maclennan, Gerard Kyle B. Abad, Johnathon M. Methven, Molly R. Gradl, Matheus D. Pinto, Ronei S. Pinto, Matt S. Stock

Research outputs 2022 to 2026

Echo intensity (EI) is a novel tool for assessing muscle quality. EI has traditionally been reported as the mean of the pixel histogram, with 0 and 255 arbitrary units (A.U.) representing excellent and poor muscle quality, respectively. Recent work conducted in youth and younger and older adults suggested that analyzing specific EI bands, rather than the mean, may provide unique insights into the effectiveness of exercise and rehabilitation interventions. As our previous work showed deterioration of muscle quality after knee joint immobilization, we sought to investigate whether the increase in EI following disuse was limited to specific EI bands. Thirteen …


Investing In Late-Life Brain Capital, Walter D Dawson, Eric J Lenze, Et Al. Jan 2022

Investing In Late-Life Brain Capital, Walter D Dawson, Eric J Lenze, Et Al.

2020-Current year OA Pubs

Within many societies and cultures around the world, older adults are too often undervalued and underappreciated. This exacerbates many key challenges that older adults may face. It also undermines the many positive aspects of late life that are of tremendous value at both an individual and societal level. We propose a new approach to elevate health and well-being in late life by optimizing late-life Brain Capital. This form of capital prioritizes brain skills and brain health in a brain economy, which the challenges and opportunities of the 21st-century demands. This approach incorporates investing in late-life Brain Capital, developing initiatives focused …


Graduate Catalog, Georgia Southern University Jan 2022

Graduate Catalog, Georgia Southern University

Graduate Catalogs

No abstract provided.


The Relationship Between Education Level, Retirement Status, And Civic Engagement Among Older Adults In Indonesia, I Komang Winata Dec 2021

The Relationship Between Education Level, Retirement Status, And Civic Engagement Among Older Adults In Indonesia, I Komang Winata

Jurnal Civics: Media Kajian Kewarganegaraan

The Indonesian population is aging very rapidly and as the number of old people increases, the number of retirees increases as well. Many scholars have argued the benefits of civic engagement in old age, but there is lack of empirical evidence of the factors associated with civic engagement in Indonesia. The aim of this study was to investigate the association between education levels, retirement status, and civic engagement among older adults in Indonesia. The study used data from the fifth wave of the Indonesia Family and Life Survey which was held in late 2014 and early 2015. The study included …


The Difference In Nutrition Intake Adequacy Amonginstitutionalized Elderly Residents With And Without Sarcopeniaat Nursing Homes In Bandung, West Java, Delia Anastasia Tirtadjaja, Muhamad Apandi, Lazuardhi Dwipa Dec 2021

The Difference In Nutrition Intake Adequacy Amonginstitutionalized Elderly Residents With And Without Sarcopeniaat Nursing Homes In Bandung, West Java, Delia Anastasia Tirtadjaja, Muhamad Apandi, Lazuardhi Dwipa

Jurnal Penyakit Dalam Indonesia

Introduction. The changes in the elderly’s daily routine including dietary intake and nutritional pattern may cause them to be more susceptible to malnutrition. The changes also increase the risk of sarcopenia that may lead to poor health outcomes such as fall injury, fracture, hospitalization, disability, or even death. Sarcopenia is more likely to occur in a nursing home compared to community settings. This study aimed to determine the difference in nutrition intake adequacy between institutionalized elderly subjects with and without sarcopenia in Bandung, West Java. Methods. A cross-sectional study was held in Ciparay and Budi Istri Nursing Home, Bandung, West …


Correlation Between Polypharmacy And Length Of Stay Geriatric Patient In Mohammad Hoesin Palembang Hospital, Iswadi Tanzil, Nur Riviati, Irsan Saleh Dec 2021

Correlation Between Polypharmacy And Length Of Stay Geriatric Patient In Mohammad Hoesin Palembang Hospital, Iswadi Tanzil, Nur Riviati, Irsan Saleh

Jurnal Penyakit Dalam Indonesia

Introduction. Geriatric patients have multipathological characteristics, low physiologic reserves, atypical clinical signs and symptoms, decreased functional status, and nutritional disturbances. This situation is a risk factor for polypharmacy. Polypharmacy is closely related to drug side effects, drug interactions, and patient compliance. Polypharmacy is thought to have a relationship with the length of stay in geriatric patients. The purpose of this study was to determine the correlation between polypharmacy and length of stay in geriatric patients at Moehammad Hoesin Hospital Palembang. Methods. This was a cross-sectional study with a correlation test design conducted at Dr. Mohammad Hoesin Hospital (RSMH) Palembang from …


Depressive Symptoms As A Predictor Factor Of All-Cause Mortality Within Six Months In Elderly Hemodialysis Patients, Langgeng Perdhana, Shofa Chasan, Yudo Murti Mupangati, Siti Nuraini Dec 2021

Depressive Symptoms As A Predictor Factor Of All-Cause Mortality Within Six Months In Elderly Hemodialysis Patients, Langgeng Perdhana, Shofa Chasan, Yudo Murti Mupangati, Siti Nuraini

Jurnal Penyakit Dalam Indonesia

Introduction. Depression is a mental disorder that is often found in the elderly and hemodialysis patients, resulting in bad effects on patients. There is no study on the relationship between depression and all-cause mortality risk in elderly hemodialysis patients in Indonesia. This study aimed to determine the role of depression as a predictor factor of all-cause mortality within 6 months in elderly hemodialysis patients. Methods. A prospective cohort study was conducted from February to August 2020 at the hemodialysis unit of Roemani Muhammadiyah Hospital, Semarang. The inclusion criteria were elderly patients (aged ≥60 years), undergoing hemodialysis ≥3 months, hemodialysis frequency …


The Effect Of Brain Vitalization Exercise On Muscle Strength And Endurance In People With Dementia, Mustika Fitri, Ajeng Fauziyah, Hana Astria Nur Dec 2021

The Effect Of Brain Vitalization Exercise On Muscle Strength And Endurance In People With Dementia, Mustika Fitri, Ajeng Fauziyah, Hana Astria Nur

Jurnal Keolahragaan

This study aims to determine the effect of brain vitalization exercise on muscle strength and endurance in people with dementia. The pre-experimental method with a one-group pretest-posttest design was used in this study. Purposive sampling technique was used in this study, then a sample of 31 people with dementia was obtained from a population of 78 people in Cibeunying Kidul District. The Arm Curl Test instrument is used in research that aims to measure arm muscle strength and Chair Stand Test which aims to measure leg muscle endurance. The data analysis technique in this study used Paired Sample T Test …


Developing A Community-Based Rehabilitation Programs In Elderly Nursing Home: A Brief Descriptive Analysis, Melinda Harini, Dosmaria Dosmaria, Herry Herry, Lisa Emilda, Listyani Herman, Nelfidayani Nelfidayani, Putu K. Mahardini, Shynta D. Hantogo, Widya Meiliana, Ikhsan Johnson, Peggy Peggy, Wanarani Aries, Widjajalaksmi Kusumaningsih, Luh K. Wahyuni Dec 2021

Developing A Community-Based Rehabilitation Programs In Elderly Nursing Home: A Brief Descriptive Analysis, Melinda Harini, Dosmaria Dosmaria, Herry Herry, Lisa Emilda, Listyani Herman, Nelfidayani Nelfidayani, Putu K. Mahardini, Shynta D. Hantogo, Widya Meiliana, Ikhsan Johnson, Peggy Peggy, Wanarani Aries, Widjajalaksmi Kusumaningsih, Luh K. Wahyuni

ASEAN Journal of Community Engagement

The need for rehabilitation services in nursing homes (NH) for the elderly is increasing each year, and this need is fulfilled both with ordinary clinical rehabilitation center visits, as well as community-based rehabilitation (CBR) inside the facility. However, a proper situation analysis is needed to establish a well-delivered CBR program in the NH, a niche to be fulfilled in this study. This study used a descriptive measurement and cross-sectional design to target the elderly who are living in the NHs. Consecutive sampling was done in the largest NH in Jakarta, in Cipayung District. Participants who were dependently ambulated were assessed …


An Age-Based Analysis Of The Perceptions Of Ageing And Successful Ageing In Malaysia, Ming Yu Cheng, Sew Kim Low, Kai-Shuen Pheh Dec 2021

An Age-Based Analysis Of The Perceptions Of Ageing And Successful Ageing In Malaysia, Ming Yu Cheng, Sew Kim Low, Kai-Shuen Pheh

Makara Human Behavior Studies in Asia

As ageism could have detrimental effects in the ageing society, it is important to know how people of different age groups perceive ageing and successive ageing. This study collected data from 648 respondents aged between 18 to 80 years old for an age-based analysis of the perceptions of ageing and successful ageing. Self- administered questionnaires were used. Correlation analysis was conducted to examine the relationship between perception of successful ageing and factors associated with psychological well-being. Our results revealed that generally, being healthy, happy and physically active are considered as important aspects of successful ageing. Younger people considered life satisfaction …


Communicative Action In Covid-19 Prevention: Does Religiosity Play A Role?, Ying Shin Chin Dec 2021

Communicative Action In Covid-19 Prevention: Does Religiosity Play A Role?, Ying Shin Chin

Asia-Pacific Social Science Review

Coronavirus disease (COVID-19) has presented the world with a major challenge in curbing infection. Information is important for public awareness of the pandemic and its prevention as part of the problem-solving efforts. Grounded on the situational theory of problem solving (STOPS), this study extends the theory by adding religiosity, an important factor that affects health-related behaviors, to examine its role as an antecedent to the situational perceptions that motivate people to take communicative action in preventing COVID-19, and to investigate the factors that lead to precautionary behavior in response to the pandemic. Based on the online survey responses from 371 …


Communicative Action In Covid-19 Prevention: Does Religiosity Play A Role?, Ying Shin Chin Dec 2021

Communicative Action In Covid-19 Prevention: Does Religiosity Play A Role?, Ying Shin Chin

Asia-Pacific Social Science Review

Coronavirus disease (COVID-19) has presented the world with a major challenge in curbing infection. Information is important for public awareness of the pandemic and its prevention as part of the problem-solving efforts. Grounded on the situational theory of problem solving (STOPS), this study extends the theory by adding religiosity, an important factor that affects health-related behaviors, to examine its role as an antecedent to the situational perceptions that motivate people to take communicative action in preventing COVID-19, and to investigate the factors that lead to precautionary behavior in response to the pandemic. Based on the online survey responses from 371 …


Conceptions Of Adult Education Teachers-In-Training Regarding The Media Literacy Education Of Older People. A Phenomenographic Study To Inform A Course Design, Hanna Vuojärvi, Sirpa Purtilo-Nieminen, Päivi Rasi, Susanna Rivinen Dec 2021

Conceptions Of Adult Education Teachers-In-Training Regarding The Media Literacy Education Of Older People. A Phenomenographic Study To Inform A Course Design, Hanna Vuojärvi, Sirpa Purtilo-Nieminen, Päivi Rasi, Susanna Rivinen

Journal of Media Literacy Education

This phenomenographic study represents part of an ongoing design-based research initiative to inform the design of a new course on older people’s media literacy in the adult-education teacher-education context. The aim was to describe the conceptions of teachers-in-training regarding media literacy education for older people. The data consist of students’ written assignments in which they defined the concept of older people, their societal roles, and of the media literacy education targeting them. The participants included teachers-in-training (N = 22) from a Finnish university’s teacher education program. The data were analyzed qualitatively with the aim of exploring how these students …


Disfunction Of Vascular Endothelium As A Pathogenetic Factor Of The Development Of Thrombophilic Conditions In Chronic Obstructive Pulmonary Disease (Review), Elnora A. Abduganieva, Irina V. Liverko, Rano K. Dadabaeva Dec 2021

Disfunction Of Vascular Endothelium As A Pathogenetic Factor Of The Development Of Thrombophilic Conditions In Chronic Obstructive Pulmonary Disease (Review), Elnora A. Abduganieva, Irina V. Liverko, Rano K. Dadabaeva

Central Asian Journal of Medicine

In world medicine, the problem of cardiopulmonary comorbidity, including the development of thrombotic cardiovascular catastrophes against the background of chronic obstructive pulmonary disease (COPD), is becoming increasingly important. Endothelial dysfunction, developing as a result of changes in the underlying pathogenesis of COPD, can increase the predisposition to cardiovascular complications - thrombosis in this group of patients. The purpose. The aim of this study was to analyze the available scientific data on the possible role of endothelial dysfunction in the high incidence of thrombotic complications in COPD. Material and research methods. The research material was the open access scientific literature of …


Development And Validation Of A Shortened And Practical Frailty Index For People With Intellectual Disabilities, J. D. Schoufour, A. Oppewal, M. C. Van Maurik, Thessa Hilgenkamp, R. G. Elbers, D. A.M. Maes-Festen Dec 2021

Development And Validation Of A Shortened And Practical Frailty Index For People With Intellectual Disabilities, J. D. Schoufour, A. Oppewal, M. C. Van Maurik, Thessa Hilgenkamp, R. G. Elbers, D. A.M. Maes-Festen

Physical Therapy Faculty Research

Background: There is no widely used instrument to detect frailty in people with intellectual disabilities (IDs). We aimed to develop and validate a shorter and more practical version of a published frailty index for people with IDs. Method: This study was part of the longitudinal ‘Healthy Ageing and Intellectual Disability’ study. We included 982 people with IDs aged 50 years and over. The previously developed and validated ID-Frailty Index consisting of 51 deficits was used as the basis for the shortened version, the ID-FI Short Form. Content of the ID-FI Short Form was based on statistics and clinical and practical …


Genetic Contributors Of Incident Stroke In 10,700 African Americans With Hypertension: A Meta-Analysis From The Genetics Of Hypertension Associated Treatments And Reasons For Geographic And Racial Differences In Stroke Studies, Nicole D. Armstrong, Vinodh Srinivasasainagendra, Amit Patki, Rikki M. Tanner, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Ethan M. Lange, Leslie A. Lange, Donna K. Arnett, Marguerite R. Irvin Dec 2021

Genetic Contributors Of Incident Stroke In 10,700 African Americans With Hypertension: A Meta-Analysis From The Genetics Of Hypertension Associated Treatments And Reasons For Geographic And Racial Differences In Stroke Studies, Nicole D. Armstrong, Vinodh Srinivasasainagendra, Amit Patki, Rikki M. Tanner, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Ethan M. Lange, Leslie A. Lange, Donna K. Arnett, Marguerite R. Irvin

Epidemiology and Environmental Health Faculty Publications

Background: African Americans (AAs) suffer a higher stroke burden due to hypertension. Identifying genetic contributors to stroke among AAs with hypertension is critical to understanding the genetic basis of the disease, as well as detecting at-risk individuals.

Methods: In a population comprising over 10,700 AAs treated for hypertension from the Genetics of Hypertension Associated Treatments (GenHAT) and Reasons for Geographic and Racial Differences in Stroke (REGARDS) studies, we performed an inverse variance-weighted meta-analysis of incident stroke. Additionally, we tested the predictive accuracy of a polygenic risk score (PRS) derived from a European ancestral population in both GenHAT and REGARDS AAs …


Late-Life Exercise Mitigates Skeletal Muscle Epigenetic Aging, Kevin A. Murach, Andrea L. Dimet-Wiley, Yuan Wen, Camille R. Brightwell, Christine M. Latham, Cory M. Dungan, Christopher S. Fry, Stanley J. Watowich Dec 2021

Late-Life Exercise Mitigates Skeletal Muscle Epigenetic Aging, Kevin A. Murach, Andrea L. Dimet-Wiley, Yuan Wen, Camille R. Brightwell, Christine M. Latham, Cory M. Dungan, Christopher S. Fry, Stanley J. Watowich

Center for Muscle Biology Faculty Publications

There are functional benefits to exercise in muscle, even when performed late in life, but the contributions of epigenetic factors to late-life exercise adaptation are poorly defined. Using reduced representation bisulfite sequencing (RRBS), ribosomal DNA (rDNA) and mitochondrial-specific examination of methylation, targeted high-resolution methylation analysis, and DNAge™ epigenetic aging clock analysis with a translatable model of voluntary murine endurance/resistance exercise training (progressive weighted wheel running, PoWeR), we provide evidence that exercise may mitigate epigenetic aging in skeletal muscle. Late-life PoWeR from 22–24 months of age modestly but significantly attenuates an age-associated shift toward promoter hypermethylation. The epigenetic age of muscle …