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Articles 9151 - 9180 of 1439299
Full-Text Articles in Entire DC Network
Stigma Predicts Participation And Autonomy In Chronic Vestibulopathy: An Explanatory Mixed Methods Study, Brandy L. Hollins
Stigma Predicts Participation And Autonomy In Chronic Vestibulopathy: An Explanatory Mixed Methods Study, Brandy L. Hollins
Dissertations, 2020-current
Many vestibular disorders are “invisible”, not widely recognized, and challenging for patients to describe. However, its impact is visible and leads to significant challenges. Research has shown that stigma associated with other chronic health conditions can detrimentally affect patient outcomes, suggesting a greater need in this area. The World Health Organization’s (WHO) International Classification of Functioning, Disability, and Health (ICF) elucidates the role of physical, social, and cultural factors in the manifestation of health conditions within a universal framework. A critical aspect of the ICF’s contextual factors for individuals with vestibular loss is societal perception. Few studies have reported stigmatization …
Louisiana State University Health Sciences Center - 2026 - 153rd Commencement, Office Of The Registrar, Lsu Health Sciences Center-No
Louisiana State University Health Sciences Center - 2026 - 153rd Commencement, Office Of The Registrar, Lsu Health Sciences Center-No
Graduation & Commencement Programs
The program for the 153rd Commencement of LSU Health Sciences Center - New Orleans held May 14, 2026.
Identity And Ideology: Dolores Ibarruri's Reconciliation Of Motherhood And Communism, Marvin Black
Identity And Ideology: Dolores Ibarruri's Reconciliation Of Motherhood And Communism, Marvin Black
Masters Theses, 2020-current
The Spanish Civil War remains a significant cornerstone of the historical narrative of the early 20th century, as it served as the political and military precursor to World War II. The war was far more complex than a simple conflict between two ideologies, with many political and military leaders often overlooked. One of these individuals was Dolores Ibárruri, a leader of the Spanish Communist Party, who called on her experiences as both a mother and a communist to galvanize support for the Second Republic. How these two facets interacted and were shaped by Ibárruri’s personal experiences is often overlooked. Through …
Sanctuary And Disappointment: Jewish German Refugees In The United States Army In World War Ii, Zachary P. Watts
Sanctuary And Disappointment: Jewish German Refugees In The United States Army In World War Ii, Zachary P. Watts
Masters Theses, 2020-current
This paper examines the experiences of German-Jewish refugees who became intelligence soldiers in the United States Army. They are frequently called the Ritchie Boys, for their training in Camp Ritchie, Maryland. The paper focuses mostly on a single Ritchie Boy named Frank Adler, who came to the United States as a teenager from Austria in 1938 and ended up returning to his hometown as a soldier. The Ritchie History museum holds a large collection of Adler’s letters which form the most important source for this project. I have found a duality of experience from German and Austrian Jews in the …
The Culinary History Of Korean Immigrants 1903-2025, Eun Soo Han
The Culinary History Of Korean Immigrants 1903-2025, Eun Soo Han
Masters Theses, 2020-current
This paper is an exploration into the role that Korean dishes like Kalbi, Korean marinated or grilled meat, and Kimchi, a fermented vegetable or fruit dish played in the development of the Korean Immigrant community and the cultivation of cultural identity of Korean immigrants. This paper offers a brief overview into the history some of the major dishes that forms the core of the three sections of this article with Kalbi being the main theme for the section on Korean immigration to Hawaii in 1903 and Kimchi being the main dish discussed in the second to third section that explores …
Vaccination-Related Applications And Health Care Professionals' Observed Changes In Human Papillomavirus Vaccine Hesitancy: Cross-Sectional Survey, Manali Desai, Shreela Sharma, Joel Fokom-Domgue, Robert Yu, Wenyaw Chan, Onyema G Chido-Amajuoyi, Charles Darkoh, Sanjay Shete
Vaccination-Related Applications And Health Care Professionals' Observed Changes In Human Papillomavirus Vaccine Hesitancy: Cross-Sectional Survey, Manali Desai, Shreela Sharma, Joel Fokom-Domgue, Robert Yu, Wenyaw Chan, Onyema G Chido-Amajuoyi, Charles Darkoh, Sanjay Shete
Faculty, Staff and Student Publications
Background: Digital tools are known to promote public health interventions such as vaccine delivery. The recommendation that health care professionals (HCPs) use vaccination-related mobile apps or web-based applications has contributed to improving vaccine awareness and acceptance in the United States. The state of Texas, which has one of the lowest human papillomavirus (HPV) vaccination rates, has seen a significant increase in HPV vaccine hesitancy, particularly during the COVID-19 pandemic.
Objective: This study aimed to examine the association between changes in HPV vaccine hesitancy observed by HCPs among patients in Texas and promotion of vaccination-related applications at the health care facilities …
Exploring Spike-Dependent And Ace2-Independent Sars-Cov-2 Interactions With Salivary Epithelial Cells In The Absence Of Ace2, Caitlynn M L Barrows, Thaise C Geremias, Simon Young, Mary C Farach-Carson
Exploring Spike-Dependent And Ace2-Independent Sars-Cov-2 Interactions With Salivary Epithelial Cells In The Absence Of Ace2, Caitlynn M L Barrows, Thaise C Geremias, Simon Young, Mary C Farach-Carson
Faculty, Staff and Student Publications
Salivary gland infection by SARS-CoV-2 requires viral entry via routes and mechanisms that remain unresolved. This study examined the expression of the angiotensin-converting enzyme 2 (ACE2) receptor in salivary tissues and basal cell-derived human salivary progenitor cells (hS/PCs), an unstudied potential entry point for SARS-CoV-2. Multiple detection modalities, including immunocytochemistry, Western blotting, flow cytometry and RT-PCR, demonstrated a consistent lack of ACE2 protein and transcript in both tissue specimens and primary salivary epithelial cells. Antigen retrieval at pH 9 was determined to be optimal for immunodetection protocols, yet ACE2 remained undetectable. Small intestine tissue served as a positive control, confirming …
Building A Road To Mitigate Ambulance Patient Offload Time (Apot), William J. Manguil
Building A Road To Mitigate Ambulance Patient Offload Time (Apot), William J. Manguil
Doctoral Projects
Emergency departments (EDs) worldwide are experiencing increased utilization resulting in care delays for patients seeking urgent treatment. Despite critical circumstances that warrant emergency medical services (EMS) response, patients arriving to the ED via ambulance remain vulnerable to delays in care due to prolonged ambulance patient offload times (APOTs). The amount of health care providers and treatment space necessary to initiate care are both limited and often strained resources which dictate the need for innovative interventions to prevent patient harm. The following project outlines the interventions implemented at the project site to improve APOT as a means to enhance patient safety …
Sexual Minority (Lgbq+) Women's Experiences Of Accessing Addiction Services: A Qualitative Study, Miriam Hillyard, Jamie Hakim, Colin Drummond, Katharine Rimes, Emmert Roberts
Sexual Minority (Lgbq+) Women's Experiences Of Accessing Addiction Services: A Qualitative Study, Miriam Hillyard, Jamie Hakim, Colin Drummond, Katharine Rimes, Emmert Roberts
School of Psychology
Introduction: Lesbian, gay, bisexual, queer and other non-heterosexual (sexual minority) women experience significant health inequities in comparison with heterosexual women. Both drug and alcohol use, and addiction to drugs and alcohol, are more prevalent for this group. They may also be more likely to underutilise addiction healthcare services in comparison to sexual minority men. Aims: We aimed to understand sexual minority women’s experiences of accessing addiction treatment services in England, UK; what prevented them from doing so if they did not; and what would have facilitated service access. Methods: A qualitative study was performed, using reflexive thematic analysis of 21 …
A Trinity Of Forces: A Critical Investigation Of The Intersection Of Lived Experience, Jesuit Secondary Education, And Corporate Curricula, Bernhard Bruno Walke
A Trinity Of Forces: A Critical Investigation Of The Intersection Of Lived Experience, Jesuit Secondary Education, And Corporate Curricula, Bernhard Bruno Walke
Dissertations
This dissertation examines how students' identities and personal experiences shape their encounters with both Jesuit Secondary Education and the Corporate Work Study Program (CWSP). Throughout this qualitative analysis, the researcher will examine how identity, secondary education, and corporate attitudes coexist, overlap, conflict, intersect, and compete with one another. By employing Gloria Ladsen-Billings’s Critical Race Theory (Ladson-Billings & Tate, 1995), Dolores Delgado Bernal and Daniel Solórzano’s contributions to Latinx Criticism (Lat Crit), (Solorzano & Bernal, 2001), Kimberlé Crenshaw’s Theory of Intersectionality (K. Crenshaw, 1989), and Tara Yosso’s Community Cultural Wealth Model (Yosso, 2005), the researcher will examine how students experience “non-linear …
Elementary Students' Science Attitudes And Teachers' Implementation Of The Ngss Science Practices: A Mixed Methods Study, Michelle Laborn
Elementary Students' Science Attitudes And Teachers' Implementation Of The Ngss Science Practices: A Mixed Methods Study, Michelle Laborn
Dissertations
It has been recorded in the literature that student science interest drops as students enter and transition to middle and high school. This dissertation takes up the areas of student science interest and the teaching of the science practices in the context of elementary education. This study seeks to understand student science interest in elementary students in the years before entering middle school where a drop of interest is frequently reported. It is hypothesized that an increased use or implementation of the NGSS science practices by classroom teachers would generate higher science interest in elementary students. In a framework of …
Justice-Oriented Pedagogy: Personal And Programmatic Commitments In Teacher Education, Cheetara A. Hudson
Justice-Oriented Pedagogy: Personal And Programmatic Commitments In Teacher Education, Cheetara A. Hudson
Dissertations
This qualitative case study examined how faculty in an urban, justice-oriented undergraduate teacher education program prepare elementary teacher candidates to develop socially just and culturally responsive teaching practices. Guided by Critical Race Theory and critical multiculturalism, this study explored how instructors integrated social justice education and culturally responsive pedagogy into coursework and field experiences. Data were collected through semi-structured interviews, classroom observations, and document analysis with four faculty members teaching foundational and methods courses. Thematic analysis revealed four key findings: (a) faculty beliefs and identities, shaped by prior K–12 teaching experiences, strongly influence their pedagogical choices; (b) instructors model justice-oriented …
Wendy Repovich Oral History Interview, Wendy Repovich, Carter Burson
Wendy Repovich Oral History Interview, Wendy Repovich, Carter Burson
Eastern Washington University Staff and Faculty Oral Histories
Professor Wendy Repovich taught Exercise Science at Eastern Washington University (EWU) from 1990-2016.
In this interview, Repovich discusses her role as one of EWU's early professors of Exercise Science. Repovich discusses her mentorship of prospective graduate students, the growth of the Exercise Science program, changes to campus during her time there, and the importance of hands-on education in the Exercise Science program.
The transcript has been reviewed by the interviewee and corrections have been made for the purposes of clarity and accuracy. The original recordings have been preserved and are available upon request.
Carter Burson interviewed Wendy Repovich in Spring …
Remembering Carlo Ferarai: Life, Community, And Death In Industrial London, William W. Wilder
Remembering Carlo Ferarai: Life, Community, And Death In Industrial London, William W. Wilder
Masters Theses, 2020-current
During the 19th century English medical schools relied on resurrection men to provide dead bodies for anatomical dissection. While resurrection men typically took bodies from graveyards, there were also those who committed murder in order to sell the bodies of their victims. Carlo Ferarai, an unhoused immigrant child, was the victim of just such a murder, and his death contributed to many legal and social changes which have been studied by historians. This paper recontextualizes Carlo’s death by exploring his life as a social history. Using court transcripts, newspapers, and other sources, alongside insights drawn from urban history, and …
Multilingual Meaning Making In Zambian Social Media Discourse: Rhetorical Framing, Identity Construction, Persuasion And Digital Writing Practices On Facebook, Mwesah Mpundu Kapesa
Multilingual Meaning Making In Zambian Social Media Discourse: Rhetorical Framing, Identity Construction, Persuasion And Digital Writing Practices On Facebook, Mwesah Mpundu Kapesa
Masters Theses, 2020-current
This study investigates how language choices in Zambian social media discourse construct identity, frame narratives, and influence audiences. Although major social media platforms are predominantly English and Eurocentric, Zambia is a highly multilingual society, creating tension between global linguistic norms and local language practices. Despite growing scholarship on digital discourse, limited research examines how Zambian users navigate multilingual communication online, particularly regarding identity construction, rhetorical framing, and audience engagement. Using a qualitative research design grounded in discourse analysis and informed by critical discourse analysis (Fairclough, 1995) and sociolinguistic theory (Gee, 2014), the study collected two weeks of Facebook data. User‑generated …
“Like Taking Your Armor Off:” Examining The Communication Challenges Faced By Lgbtq+ Liaison Officers, Emily P. Nicholson
“Like Taking Your Armor Off:” Examining The Communication Challenges Faced By Lgbtq+ Liaison Officers, Emily P. Nicholson
Masters Theses, 2020-current
Policing has been and remains one of the most significant issues facing society in the United States. One response to this issue which has seen a rise in the last decade is the presence of liaison officer programs, which are designed to help improve police relations with vulnerable groups by forging connections with local, identity-aligned organizations and practicing identity-first policing. This study sought to understand what the challenges faced by liaison programs are and what organizational tensions are experienced by police officers in LGBTQ Liaison positions. Following an inductive approach to analysis, participants in the study engaged in a semi-structured …
The Coffee Crisis: What Starbucks Coffee Company Teaches Us About Exploitation, Chloe Baker
The Coffee Crisis: What Starbucks Coffee Company Teaches Us About Exploitation, Chloe Baker
Masters Theses, 2020-current
The average American consumer associates the coffee shop with an earth-toned color pallet, a comfortable seating arrangement, and a delicious beverage. American popular culture mimics that imagery, in television shows like NBC’s Friends and Frasier, and movies like You’ve Got Mail. Coffee shops are one kind of third place, a term coined by sociologist Ray Oldenburg to describe tertiary spaces to work and home where people commune and form community. But a darker side of coffee shops exists relatively unnoticed. This thesis demonstrates how popular cultural portrayals of coffee and coffee shops—small businesses and Starbucks Coffee Company—have both …
Evaluating The Effects Of Bilingual, Video-Modified Social Story Interventions For Spanish-Speaking Children With Autism And Limited Language Abilities, Benjamin Troyer
Evaluating The Effects Of Bilingual, Video-Modified Social Story Interventions For Spanish-Speaking Children With Autism And Limited Language Abilities, Benjamin Troyer
Masters Theses, 2020-current
Social Stories ™ are interventions commonly used to target skill deficits or behavior
reduction goals for children with Autism. Most Social Story research has focused on English
speaking children with relatively advanced language abilities, limiting evidence for efficacy
with Spanish-speaking populations with lower language abilities. Some research has
demonstrated that modifying the format of a Social Story to a video format is effective at
extending the effectiveness to populations with lower language abilities. The purpose of
this study was to examine the effects of Bilingual, video-modified Social Stories on skill
acquisition and behavior reduction targets for Spanish-speaking children with ASD …
On Paper, Dallas Spears
On Paper, Dallas Spears
MFA in Visual Art
I create sculptural works from discarded copy paper that I combine with found objects, all sourced from my immediate environment. The associations of paper such as writing, tearing, stacking, folding, and scribbling echo through my formal gestures. Found objects mimic these gestures, while adding unexpected textures and colors to the compositions. These machine-made objects are intertwined with the handmade to form displays of exchange. I am interested in the tension between the manufactured and the hand-formed, and how these tensions inform our daily lives. Objects that surpass the human lifespan, products alienated from us via opaque networks of exchange, especially …
Temporal Ubiquity, Brittni Mosby
Temporal Ubiquity, Brittni Mosby
MFA in Visual Art
My thesis examines looking as a sacred and relational practice rooted in familial memory, storytelling, and the photographic archive. Drawing from early experiences of engaging family photographs alongside my mother and great-grandmother, I conceptualize these encounters as the formation of “temporal altars”: living vessels that activate space, memory, and multiplicity. These intimate acts of looking and listening position the home as a critical site where Black subjectivity is held with care and complexity.
By casting these modes of perception into domestic spaces, my thesis not only resists reductive external gazes but interrogates the archive as a colonial apparatus structured by …
Grounding In Place And Space, Levi Anthony Walker
Grounding In Place And Space, Levi Anthony Walker
MFA in Visual Art
The foundation of Levi Walker’s artistic practice relies on the use of natural materials that reference the landscape. The materials within his sculptures, in combination with sculptural processes, create a conceptual language that is in conversation with the land and the ways that we engage with it as a community. As a member of the Lumbee Tribe of North Carolina, his work addresses the relationship that Indigenous tribes have with the federal government, and the ways the tribe must navigate colonial systems in order to support their communities without erasing their identities or beliefs. Influenced by his upbringing, a strong …
Alive In Translation, Shiyao Fu
Alive In Translation, Shiyao Fu
MFA in Visual Art
Alive in Translation explores in-between cultural conditions through my process of working with materials metaphorically, focusing on how they interact and intersect. By using paradoxical pairings—organic and synthetic, fluid and rigid, liquid and solid, flux and suspension—my sculptures and installations simultaneously hold multiple conditions. My process is grounded in my own negotiations with materials. By embracing both the material limitations and my own frustrations, I allow the materials to act as active agents in my process of making. The resulting forms exist in between the materials’ own tendencies and my own intentions. My thesis project, We twist, extend, and accrete …
Integration Of Cognitive Processing Therapy For Ptsd And Cognitive-Behavioral Therapy For Co-Occurring Alcohol Use Disorder: Design And Methodology Of A Randomized Controlled Trial, Anka A Vujanovic, Sudie E Back, Debra L Kaysen, Amber M Jarnecke, Kat Roberts, Fiorela Ruiz, Kayla E Hall, Julianne C Flanagan, Joy M Schmitz, Sonya B Norman, Lyndsey Zoller, Patricia A Resick
Integration Of Cognitive Processing Therapy For Ptsd And Cognitive-Behavioral Therapy For Co-Occurring Alcohol Use Disorder: Design And Methodology Of A Randomized Controlled Trial, Anka A Vujanovic, Sudie E Back, Debra L Kaysen, Amber M Jarnecke, Kat Roberts, Fiorela Ruiz, Kayla E Hall, Julianne C Flanagan, Joy M Schmitz, Sonya B Norman, Lyndsey Zoller, Patricia A Resick
Faculty, Staff and Student Publications
Background: The prevalent comorbidity of alcohol use disorder (AUD) with posttraumatic stress disorder (PTSD) is characterized by more severe symptomatology, greater functional impairment, increased suicide risk, and poorer treatment outcomes as compared to either disorder alone. Trauma-focused, cognitive-behavioral interventions delivered alongside interventions for substance use disorders are recommended to reduce PTSD severity and substance use. Cognitive Processing Therapy (CPT) for PTSD and cognitive-behavioral therapy (i.e., Relapse Prevention [RP]) for AUD are two of the most widely used and efficacious treatments for these conditions. There are few effective integrated treatments available for PTSD/AUD comorbidity. The present study addresses this critical gap …
School Closure As Education Policy Failure: A Quantcrit Analysis Of Reform-Resistant Schools In Memphis (2010–2025), Stacy Hubbard Patton
School Closure As Education Policy Failure: A Quantcrit Analysis Of Reform-Resistant Schools In Memphis (2010–2025), Stacy Hubbard Patton
Electronic Theses and Dissertations Archive
High-stakes accountability policies have reshaped urban school governance by linking standardized test performance to decisions about intervention, restructuring, and closure. Although these systems are designed to improve low-performing schools, prior research suggests that accountability classifications reflect broader structural conditions, including racial segregation and concentrated poverty, rather than isolated instructional deficits, with schools serving Black and Latino students in historically disinvested communities bearing a disproportionate share of these consequences. This study examines the 2010–2025 achievement trajectories and survival-to-closure patterns of reform-resistant schools in Memphis–Shelby County Schools, guided by Quantitative Criticalism (QuantCrit) as both a theoretical and methodological framework. School-level administrative records …
Future-Oriented Science Education: A Delphi Study Of Policymakers’ Views From Four European Countries, Sibel Erduran, Jessica Chan, Olga Ioannidou
Future-Oriented Science Education: A Delphi Study Of Policymakers’ Views From Four European Countries, Sibel Erduran, Jessica Chan, Olga Ioannidou
School of Law, Humanities and Social Sciences
Future-oriented skills have become increasingly important in science education. These skills include critical thinking, problem solving and managing complexity. While policymaking has a direct bearing on the what and the how of a future-oriented perspective in science education, previous research focused on a narrow group of stakeholders such as teachers and students. Little is known about what policymakers perceive as significant future-oriented skills to be included in the science curriculum. By policymakers we mean government officials, legislators, educational administrators, and other influential figures who are key decision-makers in the educational eco-system. The exploratory empirical study reported in the paper employed …
Local And Indigenous Knowledge, Innovation, And Sustainable Development: Creating Sustainable Futures Amidst Crisis Conditions At The Community Level, Carlos Andrés Arias
Local And Indigenous Knowledge, Innovation, And Sustainable Development: Creating Sustainable Futures Amidst Crisis Conditions At The Community Level, Carlos Andrés Arias
Dissertations and Theses
In 1987, the Brundtland Commission's Our Common Future (1987) made clear the need to reject longstanding development processes and focus on sustainable development. The Commission stressed that actual sustainable development integrates three elements: social development, economic development, and environmental protection. Though developed nations have achieved economic growth through conventional and extractive development practices, these practices have intensified natural disasters driven by climate change, increased food insecurity, and deepened poverty. This has acutely impacted Indigenous and local communities, many of whom face crisis conditions, such as war, terrorism, civil disorder, and their aftermath. Even so, many of these communities successfully implement …
Silent No Longer: Pedro Albizu Campos And The Fbi, Noah D. Dubroff
Silent No Longer: Pedro Albizu Campos And The Fbi, Noah D. Dubroff
LSU Master's Theses
This thesis explores the Puerto Rican revolutionary, Pedro Albizu Campos, and how he evolved from a typical independence-minded young man into a radical who actively rebelled against the colonial rule of the U.S. because of the pressures applied by law enforcement agencies, especially the Federal Bureau of Investigation. The United States annexed Puerto Rico in 1898 at the conclusion of the Spanish-American War. Ever since, many Puerto Ricans have strongly advocated for their independence from the continental U.S., shaping the relationship into the present day. This article argues that the pressure and strain of such an imperial relationship influenced Albizu …
Contemporary Management Of Acute Heart Failure: From Emergency Presentation To Long-Term Remission, Jolie Bruno, Mattia Arrigo, Guillaume Baudry, Jan Biegus, Biykem Bozkurt, Kamilė Čerlinskaitė-Bajorė, Laura P Cohen, Nick Hartshorne-Evans, Shiro Ishihara, Neusa Jessen, Pieter Martens, Peder Myhre, Matteo Pagnesi, Carolyn Rosner, Novi Yanti Sari, Gianluigi Savarese, Kristoffer Grundtvig Skaarup, Aferdita Spahillari, Jozine M Ter Maaten, Heli Tolppanen, Jim L Januzzi, Alexandre Mebazaa
Contemporary Management Of Acute Heart Failure: From Emergency Presentation To Long-Term Remission, Jolie Bruno, Mattia Arrigo, Guillaume Baudry, Jan Biegus, Biykem Bozkurt, Kamilė Čerlinskaitė-Bajorė, Laura P Cohen, Nick Hartshorne-Evans, Shiro Ishihara, Neusa Jessen, Pieter Martens, Peder Myhre, Matteo Pagnesi, Carolyn Rosner, Novi Yanti Sari, Gianluigi Savarese, Kristoffer Grundtvig Skaarup, Aferdita Spahillari, Jozine M Ter Maaten, Heli Tolppanen, Jim L Januzzi, Alexandre Mebazaa
Faculty, Staff and Students Publications
Acute heart failure (AHF) represents a major global health challenge, with a substantial impact on survival, morbidity, and health care resource utilization. The clinical and economic burden associated with this condition continues to grow, highlighting the need for a timely, structured, and patient-centered approach to care. In light of the expanding body of data and evidence accumulated over recent years, it is necessary to rethink how we approach the recognition and management of AHF. This need has motivated the development of the present review, which aims to provide an updated and practical synthesis of the management of AHF-from early diagnostic …
Stimulant Medications And Bone Health, Christine M Swanson, Julie H Wolfe, Chadi A Calarge
Stimulant Medications And Bone Health, Christine M Swanson, Julie H Wolfe, Chadi A Calarge
Faculty, Staff and Students Publications
Purpose of review: This review summarizes the potential impact of stimulant medications on bone health, to raise awareness and optimize their safe use.
Recent findings: Stimulant medications can impair bone health through inadequate nutrient/calorie intake and stimulation of the sympathetic nervous system, which regulates bone metabolism. However, their use decreases fracture risk in younger populations ([Formula: see text]25 years old) with attention deficit/hyperactivity disorder (ADHD), likely through reductions in impulsivity and injury. Special care may be needed when fractures occur while using these medications, as recent data suggest psychostimulants are associated with impaired fracture healing. Prescription and non-prescription use of …
Cardiac Hdac3 Disruption Contributes To Hdac Inhibitor-Induced Qt Prolongation, Jiao Lu, Christopher Ward, Sichong Qian, Lilei Zhang, Jiang Chang, Zheng Sun
Cardiac Hdac3 Disruption Contributes To Hdac Inhibitor-Induced Qt Prolongation, Jiao Lu, Christopher Ward, Sichong Qian, Lilei Zhang, Jiang Chang, Zheng Sun
Faculty, Staff and Students Publications
Histone deacetylase (HDAC) inhibitors are approved for cancer treatment and are being investigated for a wide range of other diseases. Despite their therapeutic promise, clinical studies have reported cardiac side effects, particularly electrocardiogram (EKG) abnormalities, with QT interval prolongation being one of the most consistently reported findings. The mechanisms underlying these cardiac effects remain unclear. In this study, we investigated the role of HDAC3 in cardiac electrophysiology. We found that postnatal depletion of cardiac HDAC3 in mice caused QT interval prolongation, recapitulating the EKG abnormalities reported with HDAC inhibitor use. Adult-onset inducible depletion of cardiac HDAC3 induced additional EKG abnormalities, …