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Intensification Of Convective Heat Transfer In Tubular-Grid Packings Of Rectification Columns, Ainagul Abdiualievna Nurillaeva, Elbek Tulkinovich Mavlonov, Khabibulla Sadullaevich Nurmukhamedov, Nazora Sharofovna Khudoiberdieva Oct 2024

Intensification Of Convective Heat Transfer In Tubular-Grid Packings Of Rectification Columns, Ainagul Abdiualievna Nurillaeva, Elbek Tulkinovich Mavlonov, Khabibulla Sadullaevich Nurmukhamedov, Nazora Sharofovna Khudoiberdieva

Chemical Technology, Control and Management

The paper presents the results of an experimental study on the intensification of convective heat exchange in tubular-lattice packings of rectification columns. Currently, in various sectors of the country's economy, either plate or packed rectification columns are mainly used, and combined devices are not used. Therefore, in this paper, studies were conducted on the intensification of the rectification process by using tubes with spiral turbulators with their staggered and corridor placement in the tube sheet. Analysis of the experimental data showed that the pitch of the turbulators s/deb significantly affects the heat exchange process. At the pitch of the spiral …

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Comparative Analysis Of Not Logic Elements Implemented On Mosfet Transistors With Their Analogs Implemented On Bipolar Transistors, Nodira Batirdjanovna Аlimova, Nilufar Baxtiyorovna Gulyamova Oct 2024

Comparative Analysis Of Not Logic Elements Implemented On Mosfet Transistors With Their Analogs Implemented On Bipolar Transistors, Nodira Batirdjanovna Аlimova, Nilufar Baxtiyorovna Gulyamova

Chemical Technology, Control and Management

This paper presents a comparative analysis of existing 'NOT' logic elements (LE) based on MOSFET transistors and their analogs using bipolar transistors. It was found that the 'NOT' LE circuit implemented with n-MOS transistors is analogous to the 'NOT' LE implemented with n-p-n bipolar transistors, i.e., integral-injection logic (I2L). The circuit of the LE"NOT" made on p-MOS transistors is an analog of the LE"NOT» made on bipolar transistors of the p-n-p structure. The methodologically significant similarity between the LE"NOT," implemented on complementary MOSFET transistors, and the LE" NOT," implemented on complementary bipolar transistors (BT), using the injection-voltaic effect and representing …

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Mitochondrial Memory: Transgenerational Trauma, Functional Medicine, And Quantum Physics, Rosalynn A. Vega Oct 2024

Mitochondrial Memory: Transgenerational Trauma, Functional Medicine, And Quantum Physics, Rosalynn A. Vega

Anthropology Faculty Publications

Building from Karen Barad’s “diffractive methodological approach” (2007, 71), this article combines Mariella Pandolfi’s notion of the female body as a transgenerational “physiological memoir” (1990, 255) with functional medicine perspectives on mitochondria and advances in quantum physics around “entanglement” to explore a new concept—“mitochondrial memory.” Recent findings in biological research depict a communicating collective of mitochondria distributed across different “human” organs and describe how this collective controls many aspects of human health through epigenetic mechanisms. Since exact copies of mitochondria are inherited through the maternal line, I draw from anthropological theory, functional medicine research, and recent discoveries in physics to …

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Optimization-Based Motion Planning With Homotopy And Homology Class Constraints, Wenbo He Oct 2024

Optimization-Based Motion Planning With Homotopy And Homology Class Constraints, Wenbo He

McKelvey School of Engineering Graduate Student Theses & Dissertations

Motion Planning is a fundamental problem in robotics that aims to find an optimal trajectory for a system to move on while avoiding obstacles in the environment. Often, a feasible trajectory connecting the start and target point with the shortest length is highly desirable. Additionally, in scenarios such as drone racing or surveillance, topology constraints may arise. At the low level, the LQR or PID controller is utilized to steer the agent to move along the designed trajectory. At a high level, optimization-based, search-based, or sample-based algorithms are utilized to synthesize the feasible trajectory. In this thesis, we deal with …

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Optimization-Based Motion Planning With Homotopy And Homology Class Constraints, Wenbo He Oct 2024

Optimization-Based Motion Planning With Homotopy And Homology Class Constraints, Wenbo He

McKelvey School of Engineering Graduate Student Theses & Dissertations

Motion Planning is a fundamental problem in robotics that aims to find an optimal trajectory for a system to move on while avoiding obstacles in the environment. Often, a feasible trajectory connecting the start and target point with the shortest length is highly desirable. Additionally, in scenarios such as drone racing or surveillance, topology constraints may arise. At the low level, the LQR or PID controller is utilized to steer the agent to move along the designed trajectory. At a high level, optimization-based, search-based, or sample-based algorithms are utilized to synthesize the feasible trajectory. In this thesis, we deal with …

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Numerical Simulation Of Gas Flow In A Direct-Flow Cyclone, V.S. Toptalov, S.U. Ganieva, O.M. Flisyuk, Kh.S. Nurmukhamedov Oct 2024

Numerical Simulation Of Gas Flow In A Direct-Flow Cyclone, V.S. Toptalov, S.U. Ganieva, O.M. Flisyuk, Kh.S. Nurmukhamedov

Chemical Technology, Control and Management

A numerical model of gas flow in a direct-flow cyclone of two different configurations is presented. The main task of the simulation was to determine the gas velocity field in the apparatus and analyze the presence of a turbulent wake of the stabilizer swirled, which can have a negative impact on the efficiency of the apparatus. During the study, it was found that when the gas flow is disrupted by the stabilizer of the swirler, a turbulent wake is formed, into which trapped particles can fall. The solution to this problem is to lengthen the stabilizer and increase its diameter. …

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Flow Distribution In Magnetic Circuits Of Measuring Transducers With Distributed Parameters And A Concentrated Longitudinal Excitation Winding, Kamila Jurayeva, Javharbek Fayzullayev, Usmon Mukhtorov Oct 2024

Flow Distribution In Magnetic Circuits Of Measuring Transducers With Distributed Parameters And A Concentrated Longitudinal Excitation Winding, Kamila Jurayeva, Javharbek Fayzullayev, Usmon Mukhtorov

Chemical Technology, Control and Management

The given paper presents the flow distribution in magnetic circuits of measuring transducers with distributed resistance parameters of long ferromagnetic rods and the magnetic capacitance between them and a concentrated excitation winding using the example of a magnetic circuit of a new magnetically elastic tensile force measuring transducer. It is shown that in such magnetic circuits, the magnetic voltage and magnetic flux into the section of the excitation winding installation have maximum values, gradually decreasing from this section toward the end parts of the magnetic circuit. Suppose the rate of change of the magnetic voltage along the coordinate is practically …

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Research And Justification Of The Optimal Optical And Design Parameters Of The Activated Sludge Concentration Measuring Device For Biological Wastewater Treatment, Siroj Sobirovich Nurov, Makhsud Idrisovich Makhmudov, Uktam Farxodovich Mamirov Oct 2024

Research And Justification Of The Optimal Optical And Design Parameters Of The Activated Sludge Concentration Measuring Device For Biological Wastewater Treatment, Siroj Sobirovich Nurov, Makhsud Idrisovich Makhmudov, Uktam Farxodovich Mamirov

Chemical Technology, Control and Management

This article discusses the optimization of the design and optical parameters of an activated sludge concentration measuring device through experimental studies in laboratory conditions in order to improve the metrological characteristics of the meter. In particular, based on the optimality criteria, a more suitable type of photodetector for the meter is compared and selected; for the selected photodetector, the optimal distance with the emitter is determined, which is modern LEDs that emit light of a selective wavelength of radiation and under a certain degree of illumination. Based on the experiments conducted, it was determined that the optimal thickness between the …

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Development Of A Fuzzy Controller For Temperature Control In Phosphate Ore Beneficiation Process., D.P. Mukhitdinov, O.U. Sattarov, Sh.O. Annakulov Oct 2024

Development Of A Fuzzy Controller For Temperature Control In Phosphate Ore Beneficiation Process., D.P. Mukhitdinov, O.U. Sattarov, Sh.O. Annakulov

Chemical Technology, Control and Management

The paper presents the results of the obtained research, taking into account the dynamics of the thermal process in order to determine the parameters of the equipment and the choice of the optimal law of temperature regulation, the results of the process of temperature regulation in the process of roasting phosphate ores in the tower furnace are presented. The main purpose was to enhance the quality of phosphate ores and reduce energy consumption by using a fuzzy PID controller to regulate the temperature during the burning process of phosphate ores in a tower furnace. The parameters of the developed model …

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Fuzzy Models And Optimization By Distillation Units In The Aspen Hysys Software Environment, Nodirbek Rustambekovich Yusupbekov, Farux Tulkunovich Adilov, Janibek Alibekovich Aytbaev Oct 2024

Fuzzy Models And Optimization By Distillation Units In The Aspen Hysys Software Environment, Nodirbek Rustambekovich Yusupbekov, Farux Tulkunovich Adilov, Janibek Alibekovich Aytbaev

Chemical Technology, Control and Management

Developed fuzzy models and optimization of a deethanizer distillation column in the Aspen HYSYS software environment. This article presents the results of studies related to fuzzy modeling of distillation columns using the example of a typical deethanizer. A fuzzy computer model and optimization based on mathematical process modeling have been developed, which describes in detail technological processes using differential equations of energy transfer, material balance, hydraulics, and physicochemical kinetics inside the distillation column.

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Research On Data Collection And Transmission Technologies For Automatic Control Of High-Frequency Ozonators In Water Disinfection, P.I. Kalandarov, D.R. Ermanova, N.Zh. Duisenov, M.Zh. Koshkinbayeva, B.B. Shynzhigit, D.A. Abdullaeva, Kh.Kh. Abdullaev Oct 2024

Research On Data Collection And Transmission Technologies For Automatic Control Of High-Frequency Ozonators In Water Disinfection, P.I. Kalandarov, D.R. Ermanova, N.Zh. Duisenov, M.Zh. Koshkinbayeva, B.B. Shynzhigit, D.A. Abdullaeva, Kh.Kh. Abdullaev

Chemical Technology, Control and Management

This scientific work analyzes the research on data collection and transmission technologies for automatic control of high-frequency ozonators in water disinfection. The purpose of the study is to improve disinfection efficiency and optimize the system's operation by using IoT and artificial intelligence technologies in the control of ozonators. During the study, data collected by sensors were processed in real time through an IoT system and analyzed using artificial intelligence. Results showed that the efficiency of ozonator control increased by 25%, and ozone consumption was reduced by 20%. The use of a PID controller allowed for a 15% reduction in the …

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Analysis Of Standardization Services In An Organization And Standards Development Process Model, F.F. Fattoev, Sh.A. Turaev, A.A. Abdurakhmanov Oct 2024

Analysis Of Standardization Services In An Organization And Standards Development Process Model, F.F. Fattoev, Sh.A. Turaev, A.A. Abdurakhmanov

Chemical Technology, Control and Management

This article explores the economic significance of standardization within the industrial sector, highlighting its role in enhancing competitiveness and innovation in the Republic of Uzbekistan. Standardization, implemented across various levels (state, industry, and organizational), provides a framework for ensuring quality, safety, and technical consistency across production processes, products, and infrastructure. The article examines how standardization services, even if not separate organizational units, contribute to public interest by fostering consistency and productivity through the interdisciplinary technical coordination (TSC) system. Additionally, the research considers mathematical methods for developing standards, offering insights into how structured standardization can support automation, increase labor productivity, and …

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Development Of A Mathematical Model For An Intelligent Process Control System In Brewing Industry, A.N. Yusupbekov, M.Sh. Yusupov Oct 2024

Development Of A Mathematical Model For An Intelligent Process Control System In Brewing Industry, A.N. Yusupbekov, M.Sh. Yusupov

Chemical Technology, Control and Management

The paper deals with developing a mathematical model for a system of intelligent process control in brewing, focusing on the critical parameters of fermentation: temperature, pressure, and pH level. Mathematical models of the dynamics of the process of each of the parameters are given based on exponential dependencies, which allow for the description of the change of these values over time. The possibility of using PID regulators, neural networks, and fuzzy logic to control the process under study and the modeling that allows the optimization of beer production, improving its quality and reducing costs.

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Investigation Of Magnetic Circuits Of Measuring Transducers With A Distributed Longitudinal Excitation Winding, Javharbek Fayzullayev, Kamika Jurayeva, Usmon Mukhtorov Oct 2024

Investigation Of Magnetic Circuits Of Measuring Transducers With A Distributed Longitudinal Excitation Winding, Javharbek Fayzullayev, Kamika Jurayeva, Usmon Mukhtorov

Chemical Technology, Control and Management

The article examines the laws of distribution of magnetic voltage and magnetic flux in magnetic circuits of measuring transducers with distributed resistance parameters of long ferromagnetic rods and magnetic capacitance between them and a transverse distributed excitation winding using the example of a magnetic circuit of a new magnetically elastic force converter. It is established that in such magnetic circuits, the magnetic voltage changes its sign when passing through the section of the magnetic neutral, and the magnetic flux in the magnetic neutral has a maximum value, with a fixed value of the length of the distributed excitation winding, the …

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Generalized Structural-Parametric Conceptual Model Of The Electromagnetic Mechatronic Module, N.R. Matyokubov, T.O. Rakhimov Oct 2024

Generalized Structural-Parametric Conceptual Model Of The Electromagnetic Mechatronic Module, N.R. Matyokubov, T.O. Rakhimov

Chemical Technology, Control and Management

This article is dedicated to developing a generalized structural-parametric conceptual model of the electromagnetic mechatronic module. The design of a mechatronic module based on an electromagnetic linear motor, which performs reciprocating movements in space along different coordinates simultaneously, is presented. This module is used to enhance the functional capabilities of mechatronic systems and robotic complexes employed in modern automotive, textile, mining, metallurgy, and energy industries. It also serves to improve technical characteristics such as operational accuracy and speed. Based on this design, a computational scheme has been constructed using a van-equivalent T-shaped four-pole circuit model of the mechatronic module. It …

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Selecting The First Approach Speed Of The Igm-2k Measuring Head When Controlling The Installation Error Of Housing Parts On Tncd Machines, A.M. Abduvaliev Oct 2024

Selecting The First Approach Speed Of The Igm-2k Measuring Head When Controlling The Installation Error Of Housing Parts On Tncd Machines, A.M. Abduvaliev

Chemical Technology, Control and Management

Theoretical analysis and experimental studies have been conducted on the automatic control process for installation errors of body parts using the IGM-2K measuring head on numerically controlled machines. The results of the experimental study are presented, detailing the actual values of control errors and the time costs associated with automatic approach methods using the IGM-2K for checking the base points of body part surfaces on these machines. An algorithm for selecting the first approach speed F1 for IGM-2K has been developed. In accordance with the developed algorithm, the optimal values F1 are determined for a different range of installation errors …

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A New Method Of Determination Of Intercalibration Intervals Of Measuring Instruments Of Physico-Chemical Quantities Taking Into Account The Uncertainty Of Measurements, Sh.M. Masharipov, P.M. Matyaqubova Oct 2024

A New Method Of Determination Of Intercalibration Intervals Of Measuring Instruments Of Physico-Chemical Quantities Taking Into Account The Uncertainty Of Measurements, Sh.M. Masharipov, P.M. Matyaqubova

Chemical Technology, Control and Management

This paper presents a new method that can be applied in the field of metrology to determine and change the intercalibration periodicity during the operation of measuring instruments (certified standard chemical samples) used in the field of state metrological control and supervision. In modern metrology, the key issue is the determination and correction of intercalibration periodicity during the use of measuring instruments. The present paper presents a new method that can be applied in the sphere of state metrological control and supervision to improve the accuracy and reliability of measurements. The proposed method is intended only for exemplary measuring instruments …

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Algorithms For Minimizing The Boundary Values Of The Quadratic Quality Criterion Based On Approximation Methods, Yulduz Mukhtarkhodzhaevna Abdurakhmanova Oct 2024

Algorithms For Minimizing The Boundary Values Of The Quadratic Quality Criterion Based On Approximation Methods, Yulduz Mukhtarkhodzhaevna Abdurakhmanova

Chemical Technology, Control and Management

This paper considers approximation methods for solving optimization problems while discussing the possibility to reduce the large amount of calculations. Hence, the approximation range is selected in accordance with the optimal value of the quality indicator. To do this, the upper and lower boundaries are being calculated followed by generating the control sequences that minimize the specified boundaries. The next step is to find an approximate solution. An approximate solution to the dual control problem comes from the problem of optimal control of a linear Gaussian system with a quadratic quality criterion and unknown parameters. For the dual control problem, …

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Improvement Of Methods And Means For Increasing The Accuracy Of Instruments For Measuring The Flow Of Liquids And Gases, U.A. Ruziyev, E.E. Ortikov Oct 2024

Improvement Of Methods And Means For Increasing The Accuracy Of Instruments For Measuring The Flow Of Liquids And Gases, U.A. Ruziyev, E.E. Ortikov

Chemical Technology, Control and Management

The work is devoted to the issue of increasing the accuracy of liquid flow measurement devices, containing a primary measuring transducer for measuring the pressure drop in a narrowed section of a pipeline, temperature sensors, a microprocessor, non-volatile memory, and a communication interface. To reduce uncertainty, the liquid flow measurement temperature compensation of the flow-measuring transducer is performed based on the readings of the temperature sensor installed in the measurement environment. The secondary transducer readings are calibrated based on the temperature sensor readings installed in the computing unit of the measuring device. For reliable measurement of the gas-liquid media flow, …

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Neural Network Models Of Adaptive Position-Trajectory Control Systems Of Moving Objects, Dildora Usmonovna Sevinova Oct 2024

Neural Network Models Of Adaptive Position-Trajectory Control Systems Of Moving Objects, Dildora Usmonovna Sevinova

Chemical Technology, Control and Management

This article is devoted to neural network models of adaptive position-trajectory control systems of moving objects. Neural network models of adaptive positional-trajectory control systems of moving objects have been developed on the basis of proportional-differential adjusters, which allow for quick calculation and determination of nonlinear characteristics of the system. Also, the kinematic scheme of the multi-link industrial robot is presented for describing the motion of the multi-link industrial robot according to the specified traction and positions, and for representing the input forces and training in the neural network. Mathematical models for calculating the linear and rotational movements of the manipulator …

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System Of Monitoring And Control Of Thermal Regime In Gas-Fired Furnaces, U.U. Kholmanov Oct 2024

System Of Monitoring And Control Of Thermal Regime In Gas-Fired Furnaces, U.U. Kholmanov

Chemical Technology, Control and Management

The system of monitoring and control of thermal regime in gas furnaces is considered, the description of which includes temperature sensors, control systems and optimization algorithms. Attention is paid to monitoring, which allows to ensure stability and efficiency of furnace operation. The existing approaches to thermal regime control are analyzed. Examples of implementation of these systems are given, as well as the prospects for their development with regard to modern trends in automation and digitalization.

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Diagnosis Of Malfunctions In Servo Systems Considering Dynamic, Khurshid Salim Ugli Turaev Oct 2024

Diagnosis Of Malfunctions In Servo Systems Considering Dynamic, Khurshid Salim Ugli Turaev

Chemical Technology, Control and Management

This study analyzes methods of fault-tolerant control and automatic fault diagnosis in servo systems considering dynamic redundancy. The application of diagnostic and fault-tolerant control methods is critical for addressing reliability and safety challenges in servo systems. Dynamic redundancy ensures the ability to respond quickly to faults in individual system components and minimizes their impact on overall system performance. The research examines approaches to fault detection, ensuring continuous operation of automated systems, and methods for their effective resolution. The practical significance of the study lies in the use of modern technologies to enhance the performance and fault tolerance of servo systems.

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Method Of Selecting Elements And Designing Intelligent Optoelectronic Converters, Yuriy Gennadiyevich Shipulin, Zebiniso Akmalovna Zayniddinova, Rustam Mukhamadjonovich Rakhimov Oct 2024

Method Of Selecting Elements And Designing Intelligent Optoelectronic Converters, Yuriy Gennadiyevich Shipulin, Zebiniso Akmalovna Zayniddinova, Rustam Mukhamadjonovich Rakhimov

Chemical Technology, Control and Management

The article is devoted to the method of selecting elements and designing intelligent optoelectronic displacement transducers. It is proposed that morphological tables be used to expand the principles of building intelligent multifunctional optoelectronic converters. Choosing the optimal structure of intelligent multifunctional optoelectronic converters allows you to use a combination of advanced techniques to improve the design and use the morphological matrix of the main elements to choose a new structure of elements and designs of intelligent multifunctional optoelectronic converters.

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The Problem Of Optimal Control Of Gas-Fired Furnace Operation, Azamat Toirovich Rajabov Oct 2024

The Problem Of Optimal Control Of Gas-Fired Furnace Operation, Azamat Toirovich Rajabov

Chemical Technology, Control and Management

The formulation of the problem of optimal control of gas-burning furnace operation in the glass industry is carried out. The main stages of solving this problem, starting from mathematical modeling of the investigated process and ending with the task of optimizing the furnace thermal regime, are considered. The model describes the evolution of temperature fields of fuel combustion, combustion rate, gas movement and emission concentration changes depending on control actions. Model-based control predicts the behavior of the system for the prediction horizon and selects optimal control actions on the object.

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Research Of Electromagnetic Interference Effects On The Operational Stability Of A Measuring Device, Erkin Uljaev, Elyor Faxriddinovich Khudoyberdiev, Utkirjon Murodillayevich Ubaydullayev, Shohrux Nurali O‘G‘Li Narzullayev Oct 2024

Research Of Electromagnetic Interference Effects On The Operational Stability Of A Measuring Device, Erkin Uljaev, Elyor Faxriddinovich Khudoyberdiev, Utkirjon Murodillayevich Ubaydullayev, Shohrux Nurali O‘G‘Li Narzullayev

Chemical Technology, Control and Management

The article explores the impact of electromagnetic interference on the performance of measuring devices used in industrial environments. An experimental analysis of sensor parameters and the influence of electromagnetic fields on their accuracy was conducted. Testing methodologies utilizing shielding technologies were developed to enhance interference resistance. The results confirm the efficiency of protective shielding in ensuring stable device operation under various interference sources.

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Methods Of Synthesis Of Regulators For Nonlinear Dynamic Systems, O.O. Zaripov, D.A. Akhmedov Oct 2024

Methods Of Synthesis Of Regulators For Nonlinear Dynamic Systems, O.O. Zaripov, D.A. Akhmedov

Chemical Technology, Control and Management

Methods and algorithms for the synthesis of regulators for nonlinear dynamic systems are given, based on various approaches to the formation of a control device. We considered synthesis methods based on phase space, Lyapunov function method, vibration control, feedback linearization method, velocity gradient method, lag feedback method, adaptive, robust, intelligent approaches, fuzzy logic, systems with a variable structure, etc. All the methods of synthesis of nonlinear regulators discussed above give a solution to the problem only for rather narrow classes of objects. Therefore, the problem of building regulators for nonlinear systems in many cases has not yet been solved.

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Implementation Of The Method Of Fuzzy Control Of The Rectification Process Based On Fuzzy Logic, Yusuf Shodievich Avazov, Kamola Rustamovna Abdullaeva Oct 2024

Implementation Of The Method Of Fuzzy Control Of The Rectification Process Based On Fuzzy Logic, Yusuf Shodievich Avazov, Kamola Rustamovna Abdullaeva

Chemical Technology, Control and Management

The method of controlling the rectification process using fuzzy control based on fuzzy logic is studied. The structural scheme of the rectification process control system based on fuzzy logic is proposed. The analysis of the operation of the fuzzy rectifier is also carried out by comparing the human with the elements of fuzzy thinking. It is shown that the logical thinking of the human is similar to the functions performed by the fuzzy rectifier and the work of the components of the intellectual control system. The terms of linguistic variables are presented to reflect the rectification process of multi-component mixtures. …

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Silent Suffering: The Plight Of Foreign Doctors In The Workplace, Minzhi Ye, Mamta K. Singh Oct 2024

Silent Suffering: The Plight Of Foreign Doctors In The Workplace, Minzhi Ye, Mamta K. Singh

School of Social Work Faculty Publications

The narrator describes situations where she faced discrimination from health care professionals including her colleagues and patients. This left her feeling frustrated and unsafe in the healthcare environment.

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Spectator 2024-10-24, Editors Of The Spectator Oct 2024

Spectator 2024-10-24, Editors Of The Spectator

The Spectator

No abstract provided.

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Identification Of Allele-Specific Kiv-2 Repeats And Impact On Lp(A) Measurements For Cardiovascular Disease Risk, Sairam Behera, Jonathan R Belyeu, Xiao Chen, Luis F Paulin, Ngoc Quynh H Nguyen, Emma Newman, Medhat Mahmoud, Vipin K Menon, Qibin Qi, Parag Joshi, Santica Marcovina, Massimiliano Rossi, Eric Roller, James Han, Vitor Onuchic, Christy L Avery, Christie M Ballantyne, Carlos J Rodriguez, Robert C Kaplan, Donna M Muzny, Ginger A Metcalf, Richard A Gibbs, Bing Yu, Eric Boerwinkle, Michael A Eberle, Fritz J Sedlazeck Oct 2024

Identification Of Allele-Specific Kiv-2 Repeats And Impact On Lp(A) Measurements For Cardiovascular Disease Risk, Sairam Behera, Jonathan R Belyeu, Xiao Chen, Luis F Paulin, Ngoc Quynh H Nguyen, Emma Newman, Medhat Mahmoud, Vipin K Menon, Qibin Qi, Parag Joshi, Santica Marcovina, Massimiliano Rossi, Eric Roller, James Han, Vitor Onuchic, Christy L Avery, Christie M Ballantyne, Carlos J Rodriguez, Robert C Kaplan, Donna M Muzny, Ginger A Metcalf, Richard A Gibbs, Bing Yu, Eric Boerwinkle, Michael A Eberle, Fritz J Sedlazeck

Faculty, Staff and Students Publications

The abundance of Lp(a) protein holds significant implications for the risk of cardiovascular disease (CVD), which is directly impacted by the copy number (CN) of KIV-2, a 5.5 kbp sub-region. KIV-2 is highly polymorphic in the population and accurate analysis is challenging. In this study, we present the DRAGEN KIV-2 CN caller, which utilizes short reads. Data across 166 WGS show that the caller has high accuracy, compared to optical mapping and can further phase approximately 50% of the samples. We compared KIV-2 CN numbers to 24 previously postulated KIV-2 relevant SNVs, revealing that many are ineffective predictors of KIV-2 …

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